Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina最新文献

In the literature on the subject frequency and kind of deeds committed by people with mental illness in relation to individual clinical diagnoses are analyzed mainly, whereas little attention is paid to the issue of their psychosocial functioning. Intellectual functioning of the people manifesting delusional disorders in the course of committing attributed deeds, was on an average level. The patients' social functioning was on a low level.

Arterial hypertension is one of the most widespread diseases in the world, both in women and men. In Poland, about 45% of the adult population suffers from arterial hypertension--it afflicts 45% of men and 36-38% of women. Arterial hypertension is a set of regulatory disorders of a complicated, multifactor etiology encompassing genetic conditions, the influence of the environment and some individual factors. Being also psychosomatic disorder it is strongly linked with improper adaptation to stress, personality traits and behavioural conditions esspecially with the type A behaviour pattern. This type of behaviour includes a strong need of achievement a tendency to dominate, and aggressiveness. The type A women--impatient, aggressive, hostile to their environment, committed to work and competitive--have a higher CVR (cardiovascular reactivity) coefficient and higher arterial blood pressure than type B. Some authors suggest that the lowering of estrogen levels in women over the age of 50 increases the frequency of occurrence of arterial hypertension. In spite of the fact that we do not have a full knowledge of the mechanisms starting the reaction chain, the awareness of these factors can help us decrease the risk of the development of the disease or hinder its progression.

Chronic renal failure is connected with various cutaneous symptoms, of which the persistent pruritus is regarded as the most distressing and severily affecting the quality of life. The pathophysiology of uremic pruritus is poorly understood but believed to result from metabolic disequilibrium, increased release of pruritogenic mediators and altered balance between the opioid receptors. Several methods of controlling pruritus are considered, including pharmacologic and nonpharmacologic options, but their efficacy is still unsatisfactory.

The purpose of this study was the histological assessment of kidney glomerules in light microscopy after a single dose of adriamycin. Results of lab investigation showed that as soon as 4 weeks after adriamycin administration given peritoneally appears focal, segmental glomerulosclerosis.

Azithromycin (Sumamed, PLIVA Cracow) was administered intragastrically to rats in doses 10 times and 100 times bigger than the therapeutic dose (according to the indications for a 5-day treatment). Ultrastructural examinations of the liver were performed. Changes observed in the morphology of hepatocytes and Browicz-Kupffer cells (swelling of mitochondria, more numerous lysosomes, weaker RER content and granular material inside biliary canaliculi) may indicate temporary violation of the functional equilibrium in the liver due to the application of azithromycin.

Our investigations concerned the head of the parietal part of quadriceps femoris, and we based our investigation on observations of the ultrastructure of muscle fibers using an electron microscope. We observed tissue samples taken from patients (10 men) 25-35 years old, who had old damage of knee joint ligament (after about 6 week's immobilization). In the first group, segments of tissue of parietal head of quadriceps femoris were taken inter-operationally from patients in whom there was found old damage of knee joint ligament. The second group was of tissue segments of this muscle after surgical repair of knee and rehabilitation, which consisted in power training using resistance machines. The muscle fiber samples of quadriceps femoris which were taken from patients during the first operation, showed big changes in their ultrastructure. These changes included: myofibrils disintegration; disturbance of regularly arranged striation in sarcomers; dissappearance of Z line. In the sarcoplasm, we observed large vacuolisation, and in the interfibrillar spaces--an accumulation of exudate and morphotic elements of blood outside the capillary vessels. Observations of muscle tissue after regeneration, showed a big improvement in the muscle cell's ultrastructure--the myofibrils were regularly arranged, and the sarcomers striations showed no deviations from normal structure. We also observed a considerable increase in the number of properly formed ultrastructure mitochondria when compared with the first group.

The concentrations of heavy metals (Pb, Cd, Cr, Cu, Mn and Zn) were analyzed in the soils of the Rejowiec Fabryczny area. The levels of these metals were also measured in the raw materials used in cement production, in cement itself, and in dust removed by electrofilters mounted over the clinker kilns. Morbidity rates were also analyzed of children up to 6 years of age examined and treated in the local ambulatory medical center in Rejowiec Fabryczny in 1982 and 2002. The soils of the Rejowiec Fabryczny area showed elevated levels of Pb, Cd, Zn and Cu, comparing to the reference values. Installation of electrofilters in the cement plant resulted in a considerable reduction of Pb and Cd discharge. It was observed that the frequency of respiratory disorders in children from the Rejowiec Fabryczny area was higher comparing to other regions. Over the last 20 years, the frequency of allergies and asthma increased.

The experience of emotional bonds created by spouses through mutual relationship is significant for reaching the state of satisfaction and fulfilling personal needs. Neurosis disorders of one spouse have a significant influence on conjugal situation in many aspects, such as: the level of satisfaction from marriage and social contacts of a family.

The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.

Ascorbic acid concentration in a living body undergoes alterations continually. The changes in homeostasis of this important antioxidant may be induced by the effect of sex hormones for example. Based on this, the aim of our work was to estimate the influence of sex hormones administration and vitamin E supplementation on tissue ascorbic acid concentration in female and male rats. It has been showed that estrogen administration to females resulted in vitamin C loss, while testosterone administration to males elevated this level in all the tested tissues. However, the supplementation of vitamin E during sex hormones administration had beneficial effects on the tissue ascorbic acid concentration.