Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina最新文献

In the paper were shown the methods of the local innervated skin flaps, harvested from the posterior surface of the lower leg, the lateral malleolus region and the plantar surface of the foot, used in treatment of soft tissues defects of posterior and plantar surface of the heel.

The aim of this study was to assess the serum concentration of F1 + 2 in patients with liver cirrhosis developed during HCV infection and in patients with chronic hepatitis C infection. The study group consisted of 52 patients hospitalised at the Department of Infectious Diseases of Medical University of Lublin, Poland. Among them, 18 patients (8 men and 10 women), aged 19-59 years, had a stable liver cirrhosis and 34 patients (21 men and 13 women), aged 20-41 years, were diagnosed with chronic hepatitis C infection. The control group consisted of 25 healthy individuals (13 men and 12 women), aged 19-60 years. The serum concentration of F1 + 2 was determined by the immunoenzymatic assay Enzygnost F1 + 2 micro. There were no statistically significant differences observed in serum concentration of F1 + 2, both in patients with stable cirrhosis and with CHC, compared to controls. However, in 16.7% of patients with cirrhosis and in 35.3% of patients with CHC elevated serum levels of F1 + 2 were observed.

The authors presented three cases of patent ductus arteriosus (PDA) diagnosed in adulthood as an solated defect in patients without clinical signs using echocardiography and MSCT. The paper discusses extensively the techniques of both examinations, the use of various reconstructive algorithms in MSCT and possible visualization of the arterial duct as well as concomitant changes in the vessels and heart. SCT, although not used in PDA diagnosis to date, was found to be a valuable non-invasive diagnostic method of detecting this defect in patients in whom echocardiography failed or in examinations conducted due to non-cardiological clinical indications.

Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It shows a wide range of biologic activities that include the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

The objective of the present research study was to compare some parameters of human semen of positive immunoenzymatic test for the Chlamydia trachomatis presence in blood serum with the results of those with the negative test results. Seventy (70) men with genitourinary system problems were examined: in 33 cases positive chlamydial tests were found as compared to 37 negative tests. The parameters of semen were compared in both groups. Statistically significant sperm reduced motility was found in the group with positive chlamydial test results.

The renal corpuscles of the kidney of white Wistar rats was examined. The animals were given Cladribine (2-CdA) subcutaneously at the dosages of 0.07 mg/kg b.w./24 h for 7 days and 0.1 mg/kg b.w./24 h for 6 days in 3 courses with 5 weeks' break between each. The animals were killed in each instance, 24 hours after the last dose of the drug and 4 weeks after the last dose. The kidney samples were taken for histological and histochemical examination, then stained with hematoxylin and eosin, using the Masson's, PAS, and Feulgen's methods. In all of the groups, changes were observed but the intensity differed, with widening or narrowing of the urinary space, thickening of the basement membrane of the parietal layer of the Bowman's capsule and the basement membrane of capillaries, and density changes in capillary vessels. Hyperaemia in renal glomeruli and in all parenchyma, and infiltrations around the tubules and renal glomeruli, were also observed.

In recent years, the increase in incidence of malignant tumours of breast has been observed in Poland. Every year approximately 10 thousands of new cases of breast cancer are registered. 19 per cent of all women afflicted with malignant neoplasms suffer from breast cancer. According to considerable experience of the western countries, prophylaxis combined with screening examinations is the most effective and, also, the cheapest method of fighting against neoplasm. In the face of steadily growing danger, which affects more and more women, an attempt to assess the knowledge and behaviour towards prophylaxis of breast cancer among women over 35 was made. The researches, carried out between April and November 2002, were conducted with the use of our own questionnaire basing upon literature on the subject. The poll was intended for women aged between 35 and 60. The group of 300 women, who live in the south-east part of Poland, was surveyed. A detailed analysis of the data revealed that almost 50 per cent of women know the rules of preventive actions in the spheres of breast self-control and mammography. The level of knowledge of primary prophylaxis correlates with the level of education of women. The higher is education, the greater is knowledge about the risk factors of breast cancer. The highly educated women more often and more systematic take preventive actions leading to early detection of breast cancer. The women in the 35-45 age group more regularly and more often perform monthly breast self-control. Also the fact of the prevalence of breast cancer in the members of the polled women's families raises the discipline of performed examination.

The ARCUSdigma is an electronic facebow enabling presentation and graphic analysis of mandibular movements on the computer screen. A kinematic hinge axis of the mandible can be determined using this device. The paper presents the diagnostic potential of the ARCUSdigma in relation to programming an articulator according to individual parameters of mandibular movements of the patient and its application in the diagnosis of temporo-mandibular joints.

The oxazolidinones are a new class of broad spectrum chemotherapeutics of antibiotic properties. These drugs have good activity against Gram-positive pathogenic bacteria. Oxazolidinones possess an unique mechanism of inhibitory bacterial protein biosynthesis. These compounds inhibit the formation of N-formylmethionyl-tRNA, which is a requisite of beginning translation process. Linezolid, the first oxazolidinone to be approved for the clinical treatment of Gram-positive bacterial infections, displays a wide spectrum of in vitro activity against many important pathogens, including for instance methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and penicillin-resistant pneumococci. Linezolid is a pararental drug that also possesses near-complete oral bioavailability and a favourable pharmacokinetic profile. In clinical trials involving hospitalised patients with skin and soft tissue infections oxazolidinones appeared to be effective treatment option, comparable in efficacy to vancomycin.

Coronary artery aneurysms are very rare abnormalities in patients undergoing coronary angiography. Clinical manifestation is usually that of coronary artery disease, and acute myocardial infarction. We present the case of a patient admitted to the Department of Cardiac Surgery due to coronary artery disease and the presence of thrombus in right atrium of the heart diagnosed by transthoracic echocardiography. Coronary angiography showed occlusion of the right coronary artery (RCA) in its middle portion, 20% stenosis of the stem of the left coronary artery in distal portion and occlusion of circumflex coronary artery (CX) and the second obtuse marginal branch (OM 2). During surgery no tumor was found within the right atrium, but right coronary artery giant aneurysm was revealed. The totally thrombosed aneurysm was removed with additional performance of two venous grafts to RCA and OM 2. The postoperative course was uneventful.