Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.01.07
Saf Zg, Emine N, Derya Tanriverd, Sevde Erol
Objective: This study was conducted to adapt the cardiac self-blame scale developed by Harry et al. in 2018 into Turkish. Materials and Methods: The sample of the study consisted of 125 patients with cardiovascular disease. Confirmatory (CFA)factor analyses were conducted to examine the construct validity of the scale and the correlation of it between similar scales was analyzed within the scope of criterion validity. As a result of confirmatory factor analysis, it was observed that the two-factor (Behavioral Self-Blame and Characterological Self-Blame) structure of the scale was preserved in the Turkish sample as well. Results: In the analysis performed for criterion-related validity, significant correlations were found between the scale and other scales (p<0.01). Conclusion: The findings obtained because of the validity and reliability studies of the cardiac self-blame attributions scale, which was adapted into Turkish, revealed can be used to determine the accusations against the behavior and characters of individuals with cardiac disease in Turkish society.
{"title":"Validity and Reliability of the Cardiac Self-Blame Attributions Scale in Turkish","authors":"Saf Zg, Emine N, Derya Tanriverd, Sevde Erol","doi":"10.5455/annalsmedres.2023.01.07","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.07","url":null,"abstract":"Objective: This study was conducted to adapt the cardiac self-blame scale developed by Harry et al. in 2018 into Turkish. Materials and Methods: The sample of the study consisted of 125 patients with cardiovascular disease. Confirmatory (CFA)factor analyses were conducted to examine the construct validity of the scale and the correlation of it between similar scales was analyzed within the scope of criterion validity. As a result of confirmatory factor analysis, it was observed that the two-factor (Behavioral Self-Blame and Characterological Self-Blame) structure of the scale was preserved in the Turkish sample as well. Results: In the analysis performed for criterion-related validity, significant correlations were found between the scale and other scales (p<0.01). Conclusion: The findings obtained because of the validity and reliability studies of the cardiac self-blame attributions scale, which was adapted into Turkish, revealed can be used to determine the accusations against the behavior and characters of individuals with cardiac disease in Turkish society.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"238 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86196425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.09.282
brahim ksel, Ali nda, M. Z., Mehmet ven
Aim: This retrospective study aimed to determine the incidence of random findings in digital panoramic images acquired from edentulous patients presenting for conventional prosthetic rehabilitations or implant-supported dentures. Materials and Methods: In this retrospective study, of the patients aged 16 years and older, 950 of 1100 panoramic films were evaluated by two maxillofacial radiologists (MA and IBY) in ambient light on an LCD monitor. The final classification and radiographic status of each finding were recorded after inter-observer consensus. Radiographs with low image quality and artifacts that did not include the demographic information of the patients were not included in the study. In the present study; impacted teeth, root remnants, radiolucent (RL) lesions, radiopaque (RO) lesions (including idiopathic osteosclerosis), foreign bodies, crest atrophies, soft tissue calcifications, maxillary sinus opacities, and Stafne bone defects were examined. Lesions affecting the alveolar region were divided into three regions as anterior (incisors and canines region), premolars and molars region. Results: Tonsillitis was observed in a total of 55 individuals, 26 men and 29 women. Sialolith was seen in a total of 3 patients, 2 male and 1 female, but phleboliths were not found in any of them. Styloid ligament ossification(SLO) was seen in a total of 125 patients, 69 of these cases were female and 56 were male, however calcified atherosclerotic plaque is the most common calcification with 156 individuals and a rate of 16.4% among calcifications. Laryngeal cartilage calcification, which is seen in 36 female and 23 male individuals. Conclusion: The outcome of this study indicated that the ratio of advantageous findings fixed in digital panoramic images of totally edentulous patients was highly rated. There are indispensable for patients with total edentulism such as routine use and careful examination of panoramic images.
{"title":"Evaluation of Panoramic Radiographs of Totally Edentulous Jaws: A Retrospective Study","authors":"brahim ksel, Ali nda, M. Z., Mehmet ven","doi":"10.5455/annalsmedres.2022.09.282","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.282","url":null,"abstract":"Aim: This retrospective study aimed to determine the incidence of random findings in digital panoramic images acquired from edentulous patients presenting for conventional prosthetic rehabilitations or implant-supported dentures. Materials and Methods: In this retrospective study, of the patients aged 16 years and older, 950 of 1100 panoramic films were evaluated by two maxillofacial radiologists (MA and IBY) in ambient light on an LCD monitor. The final classification and radiographic status of each finding were recorded after inter-observer consensus. Radiographs with low image quality and artifacts that did not include the demographic information of the patients were not included in the study. In the present study; impacted teeth, root remnants, radiolucent (RL) lesions, radiopaque (RO) lesions (including idiopathic osteosclerosis), foreign bodies, crest atrophies, soft tissue calcifications, maxillary sinus opacities, and Stafne bone defects were examined. Lesions affecting the alveolar region were divided into three regions as anterior (incisors and canines region), premolars and molars region. Results: Tonsillitis was observed in a total of 55 individuals, 26 men and 29 women. Sialolith was seen in a total of 3 patients, 2 male and 1 female, but phleboliths were not found in any of them. Styloid ligament ossification(SLO) was seen in a total of 125 patients, 69 of these cases were female and 56 were male, however calcified atherosclerotic plaque is the most common calcification with 156 individuals and a rate of 16.4% among calcifications. Laryngeal cartilage calcification, which is seen in 36 female and 23 male individuals. Conclusion: The outcome of this study indicated that the ratio of advantageous findings fixed in digital panoramic images of totally edentulous patients was highly rated. There are indispensable for patients with total edentulism such as routine use and careful examination of panoramic images.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77435266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.10.317
M. Erdoğan, E. Erdoğan
Aim: The COVID-19 has spread rapidly around the world. Apart from primarily targeting the lungs and causing acute respiratory distress syndrome with severe respiratory symptoms and high risk of death, the disease can also cause damage to other organs such as the heart, kidney, and testis. Studies have shown that men are more likely to get infected by the disease than women and the death rate due to the disease is found to be higher in men. We aimed to show the effects of COVID-19 on sperm parameters. Materials and Methods: In the study, semen analyzes of COVID-19 patients and healthy control groups were compared according to the presence or absence of PCR-confirmed SARS-CoV-2 positivity in hospital records. Patients with COVID-19 (+) were the patients who had mild disease. A total of 510 participants, 53 COVID-19 patients and 457 healthy control groups. After positivity confirmation of recovered COVID-19 patients using PCR, semen analysis was performed after an average of 157 (24-355) days. Also, in order to evaluate the short-term and long-term effects of the disease, patients were grouped as those with less than 90 days and more than 90 days after receiving the positive PCR result. Results: While the mean progressive motility of sperm was 41.45 (19.21) in the recovered COVID-19 patients, it was 38.35 (21.74) in the control group. The mean total motility was 55.74 (19.34) in recovered COVID-19 patients, where as it was 51.84 (22.45) in control group. The percentage of normal sperm morphology was 11.45 (5.97) in recovered COVID-19 patients, however it was 11.19 (8.08) in control group. The sperm concentration was found to be 68.60 (56.22) x 106/ml in recovered COVID-19 patients, but it was 74.10 (61.72) x 106/ml in control group. Finally, the mean sperm immobility was 44.26 (19.34) in recovered COVID-19 group, however it was 48.16 (22.45) in control group. Conclusion: In the study, when the semen analysis results of patients who recovered after COVID-19 and healthy control groups were compared in terms of semen parameters according to the recovery time period, no statistically significant difference was found. More studies are needed to fully understand the effects of COVID-19 on the reproductive system.
{"title":"Analysis of Semen Parameters of Recovered Patients after COVID-19","authors":"M. Erdoğan, E. Erdoğan","doi":"10.5455/annalsmedres.2022.10.317","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.317","url":null,"abstract":"Aim: The COVID-19 has spread rapidly around the world. Apart from primarily targeting the lungs and causing acute respiratory distress syndrome with severe respiratory symptoms and high risk of death, the disease can also cause damage to other organs such as the heart, kidney, and testis. Studies have shown that men are more likely to get infected by the disease than women and the death rate due to the disease is found to be higher in men. We aimed to show the effects of COVID-19 on sperm parameters. Materials and Methods: In the study, semen analyzes of COVID-19 patients and healthy control groups were compared according to the presence or absence of PCR-confirmed SARS-CoV-2 positivity in hospital records. Patients with COVID-19 (+) were the patients who had mild disease. A total of 510 participants, 53 COVID-19 patients and 457 healthy control groups. After positivity confirmation of recovered COVID-19 patients using PCR, semen analysis was performed after an average of 157 (24-355) days. Also, in order to evaluate the short-term and long-term effects of the disease, patients were grouped as those with less than 90 days and more than 90 days after receiving the positive PCR result. Results: While the mean progressive motility of sperm was 41.45 (19.21) in the recovered COVID-19 patients, it was 38.35 (21.74) in the control group. The mean total motility was 55.74 (19.34) in recovered COVID-19 patients, where as it was 51.84 (22.45) in control group. The percentage of normal sperm morphology was 11.45 (5.97) in recovered COVID-19 patients, however it was 11.19 (8.08) in control group. The sperm concentration was found to be 68.60 (56.22) x 106/ml in recovered COVID-19 patients, but it was 74.10 (61.72) x 106/ml in control group. Finally, the mean sperm immobility was 44.26 (19.34) in recovered COVID-19 group, however it was 48.16 (22.45) in control group. Conclusion: In the study, when the semen analysis results of patients who recovered after COVID-19 and healthy control groups were compared in terms of semen parameters according to the recovery time period, no statistically significant difference was found. More studies are needed to fully understand the effects of COVID-19 on the reproductive system.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85734272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Iron deficiency anemia (IDA) is a significant health problem in pregnant women. We aimed to evaluate the effect of gestational IDA and to compare the results of iron therapy in pregnant women. Methods: This retrospective cohort study of pregnant women in the third trimester analyzed the records of 63 women not taking any iron supplements, 70 women receiving intravenous ferric carboxymaltose therapy (FCM), and 73 pregnant women receiving oral iron therapy. It compared maternal and neonatal outcomes of the three groups. Results: The mean age of the 206 pregnant women included in the study was 29.19±4.34 (19-44; min–max). Only 1% of anemic women received a blood transfusion in the postpartum period. There was no difference between the groups' mean age and gestational week. The median values of gravida and parity were the same in all 3 groups (Gravida=2, Parity=1). Maternal hemoglobin (Hb) value of the non-iron group was lower than that of the other groups (p<0.001). Although the mothers' Hb levels at birth were different, the newborns' Hb values were not affected (p=0.547). Neonatal height and weight were lower in the non-iron group than in the FCM and oral iron groups (p=0.048 and p<0.001, respectively). Neonatal head circumference, 1-minute Apgar, and 5-minute Apgar scores were similar in all three groups. Conclusion: FCM is effective in pregnant women with IDA in late pregnancy and women undergoing this treatment deliver healthier newborns.
{"title":"What is the best treatment for anemia in pregnant women in the third trimester: Ferric carboxymaltose or oral iron therapy?","authors":"Elif Eren, Yakup Karakurt, Sevil Sadri, Gamze Demirel","doi":"10.5455/annalsmedres.2023.09.246","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.09.246","url":null,"abstract":"Objective: Iron deficiency anemia (IDA) is a significant health problem in pregnant women. We aimed to evaluate the effect of gestational IDA and to compare the results of iron therapy in pregnant women. Methods: This retrospective cohort study of pregnant women in the third trimester analyzed the records of 63 women not taking any iron supplements, 70 women receiving intravenous ferric carboxymaltose therapy (FCM), and 73 pregnant women receiving oral iron therapy. It compared maternal and neonatal outcomes of the three groups. Results: The mean age of the 206 pregnant women included in the study was 29.19±4.34 (19-44; min–max). Only 1% of anemic women received a blood transfusion in the postpartum period. There was no difference between the groups' mean age and gestational week. The median values of gravida and parity were the same in all 3 groups (Gravida=2, Parity=1). Maternal hemoglobin (Hb) value of the non-iron group was lower than that of the other groups (p<0.001). Although the mothers' Hb levels at birth were different, the newborns' Hb values were not affected (p=0.547). Neonatal height and weight were lower in the non-iron group than in the FCM and oral iron groups (p=0.048 and p<0.001, respectively). Neonatal head circumference, 1-minute Apgar, and 5-minute Apgar scores were similar in all three groups. Conclusion: FCM is effective in pregnant women with IDA in late pregnancy and women undergoing this treatment deliver healthier newborns.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.213
Bet l, Eylem Ate, Serhat l, Nisa larslan, Dilek Konuksever, Bet Ulukol
Aim: Sharenting, the act of parents sharing content related to their children on social media, has become a prevalent practice in today's digital age. However, concerns have been raised about the potential privacy violations and risks that this behavior may expose children to. This study aimed to investigate sharenting behaviors among Turkish parents and validate the Turkish version of the Sharenting Evaluation Scale (SES). Materials and methods: Following World Health Organization guidelines, the original SES was translated into Turkish. The scale's content validity was evaluated by experts before being administered to 276 Turkish parents. Results: The overall reliability of the scale was determined to be 0.855, which indicates its strong reliability. To further enhance the scale's reliability, the tenth item was removed after examining item-total statistics, resulting in an improved Cronbach's alpha of 0.87 for the total scale. Subscale reliability was also satisfactory, with values of 0.92 for implications, 0.64 for social behavior, and 0.68 for self-control. Confirmatory Factor Analysis (CFA) was employed to assess the construct validity of the scale. The chi-square test indicated a significant fit (p<0.001, chi-square/df = 241.1/100 = 2.411), supporting the scale's reliability and measurement ability. Conclusion: The Turkish version of the 16-item SES demonstrated good reliability and validity, making it a valuable tool for assessing sharenting behaviors among Turkish parents. By utilizing this scale, healthcare professionals and researchers can gain crucial insights into parental sharing practices on social media and better understand the potential risks and implications for children's privacy and safety.
{"title":"Measuring Sharenting Behavior: Validity and Reliability of the Turkish Version of the Sharenting Evaluation Scale","authors":"Bet l, Eylem Ate, Serhat l, Nisa larslan, Dilek Konuksever, Bet Ulukol","doi":"10.5455/annalsmedres.2023.08.213","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.213","url":null,"abstract":"Aim: Sharenting, the act of parents sharing content related to their children on social media, has become a prevalent practice in today's digital age. However, concerns have been raised about the potential privacy violations and risks that this behavior may expose children to. This study aimed to investigate sharenting behaviors among Turkish parents and validate the Turkish version of the Sharenting Evaluation Scale (SES). Materials and methods: Following World Health Organization guidelines, the original SES was translated into Turkish. The scale's content validity was evaluated by experts before being administered to 276 Turkish parents. Results: The overall reliability of the scale was determined to be 0.855, which indicates its strong reliability. To further enhance the scale's reliability, the tenth item was removed after examining item-total statistics, resulting in an improved Cronbach's alpha of 0.87 for the total scale. Subscale reliability was also satisfactory, with values of 0.92 for implications, 0.64 for social behavior, and 0.68 for self-control. Confirmatory Factor Analysis (CFA) was employed to assess the construct validity of the scale. The chi-square test indicated a significant fit (p<0.001, chi-square/df = 241.1/100 = 2.411), supporting the scale's reliability and measurement ability. Conclusion: The Turkish version of the 16-item SES demonstrated good reliability and validity, making it a valuable tool for assessing sharenting behaviors among Turkish parents. By utilizing this scale, healthcare professionals and researchers can gain crucial insights into parental sharing practices on social media and better understand the potential risks and implications for children's privacy and safety.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.229
Bilge r, Serkan k, g cel, meral karada
Background and Aim: Our study aimed to find the relationship between MPV (Mean Platelet Volume) levels, a marker of inflammation, and platelet counts between simple and complex febrile seizures. Materials and Methods: In this retrospective comparative study, we analyzed the records of 283 children between the ages of 6 months and 6 years who were diagnosed with simple and complex febrile seizures (BFN/CFN) in the Pediatric Neurology Clinic of XXX University, Faculty of Medicine between January 2021 and December 2022. Results: The mean age and gender characteristics of the patients were similar in both groups. The MPV of the CFN group (69 patients) (6.53±0.39fl) was lower than that of the BFN group (214 patients) (7.81±0.43fl) and this difference was statistically significant (p<0.01). The platelet count of the CFN group (257.42×103±126.01×103) was higher than that of the BFN group (191.23×103±68.29×103) and the difference was statistically significant (p<0.01). Conclusion: There was a significant difference between BFN and CFN groups in terms of both MPV values and platelet counts. This study suggests that detailed and comprehensive studies on MPV and platelet counts may guide cases where clinical findings are suspicious and the distinction between BFN and CFN cannot be clearly differentiated.
{"title":"The Role of Mean Platelet Volume/Platelet Count in Differentiation of Simple and Complex Febrile Seizures","authors":"Bilge r, Serkan k, g cel, meral karada","doi":"10.5455/annalsmedres.2023.08.229","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.229","url":null,"abstract":"Background and Aim: Our study aimed to find the relationship between MPV (Mean Platelet Volume) levels, a marker of inflammation, and platelet counts between simple and complex febrile seizures. Materials and Methods: In this retrospective comparative study, we analyzed the records of 283 children between the ages of 6 months and 6 years who were diagnosed with simple and complex febrile seizures (BFN/CFN) in the Pediatric Neurology Clinic of XXX University, Faculty of Medicine between January 2021 and December 2022. Results: The mean age and gender characteristics of the patients were similar in both groups. The MPV of the CFN group (69 patients) (6.53±0.39fl) was lower than that of the BFN group (214 patients) (7.81±0.43fl) and this difference was statistically significant (p<0.01). The platelet count of the CFN group (257.42×103±126.01×103) was higher than that of the BFN group (191.23×103±68.29×103) and the difference was statistically significant (p<0.01). Conclusion: There was a significant difference between BFN and CFN groups in terms of both MPV values and platelet counts. This study suggests that detailed and comprehensive studies on MPV and platelet counts may guide cases where clinical findings are suspicious and the distinction between BFN and CFN cannot be clearly differentiated.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.02.061
A. M. Res, M. Yucel, O. Aktas, O. Zengi, A. Tas, A. Tufan, B. Eren, Feyza Karagoz, Guzey
Background: Crush injury damages the nerve, affects its function and causes oxidative stress. Alpha-lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this study, we aimed to investigate the effects of ALA in the treatment of crush sciatic nerve injury in rats. Materials and Methods: Forty rats were divided into five groups. Walking Track Analysis (WTA) was performed in all groups before sacrificing the sciatic nerve. In group I (sham group), the sciatic nerve was exposed but not crushed, whereas in group II (early control group, 24th hour), group III (late control group, 7th day), group IV (early experimental group, 24th hour), and group V (late control group, 7th day), the sciatic nerve was exposed and clipped with an aneurysm clip for 300 seconds. One hour after the crush injury, subjects in groups II and III were given saline (2.5 ml, intraperitoneally), while ALA (100 mg/kg, intraperitoneally) was administered in Groups IV and V. WTA was performed in Groups I, II, and IV at the 24th hour after clipping and was performed in Groups III and V at 7th day after clipping. In all groups, the Sciatic Functional Index (SFI) was calculated after WTA. Following the completion of WTA, sciatic nerve tissue samples were obtained for the measurement of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzyme values. Results: The SFI scores in groups II, III, IV, and V were significantly lower than that of sham group (p˂0.05), while no significant difference was found between groups II and IV and between groups III and V (p>0.05). The CAT values of groups II and IV, the GSH-Px value and MDA value of group IV, and the SOD values of groups II and IV were found to be significantly higher than those of sham group (p<0.05). However, no significant difference was found among groups I, III, and V with regard to CAT, GSH-Px, MDA and SOD values (p>0.05). Conclusion: The results indicated that a single dose of ALA (100 mg/kg) administered intraperitoneally one hour after the sciatic nerve crush injury had no therapeutic efficacy at 24 hours and 7 days after the administration. Further experimental studies are needed to evaluate the effectiveness of ALA applied in several doses rather than a single dose in crush peripheral nerve injury models.
{"title":"The effect of Alpha-Lipoic Acid on nerve tissue healing after sciatic nerve crush injury in rats","authors":"A. M. Res, M. Yucel, O. Aktas, O. Zengi, A. Tas, A. Tufan, B. Eren, Feyza Karagoz, Guzey","doi":"10.5455/annalsmedres.2023.02.061","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.061","url":null,"abstract":"Background: Crush injury damages the nerve, affects its function and causes oxidative stress. Alpha-lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this study, we aimed to investigate the effects of ALA in the treatment of crush sciatic nerve injury in rats. Materials and Methods: Forty rats were divided into five groups. Walking Track Analysis (WTA) was performed in all groups before sacrificing the sciatic nerve. In group I (sham group), the sciatic nerve was exposed but not crushed, whereas in group II (early control group, 24th hour), group III (late control group, 7th day), group IV (early experimental group, 24th hour), and group V (late control group, 7th day), the sciatic nerve was exposed and clipped with an aneurysm clip for 300 seconds. One hour after the crush injury, subjects in groups II and III were given saline (2.5 ml, intraperitoneally), while ALA (100 mg/kg, intraperitoneally) was administered in Groups IV and V. WTA was performed in Groups I, II, and IV at the 24th hour after clipping and was performed in Groups III and V at 7th day after clipping. In all groups, the Sciatic Functional Index (SFI) was calculated after WTA. Following the completion of WTA, sciatic nerve tissue samples were obtained for the measurement of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzyme values. Results: The SFI scores in groups II, III, IV, and V were significantly lower than that of sham group (p˂0.05), while no significant difference was found between groups II and IV and between groups III and V (p>0.05). The CAT values of groups II and IV, the GSH-Px value and MDA value of group IV, and the SOD values of groups II and IV were found to be significantly higher than those of sham group (p<0.05). However, no significant difference was found among groups I, III, and V with regard to CAT, GSH-Px, MDA and SOD values (p>0.05). Conclusion: The results indicated that a single dose of ALA (100 mg/kg) administered intraperitoneally one hour after the sciatic nerve crush injury had no therapeutic efficacy at 24 hours and 7 days after the administration. Further experimental studies are needed to evaluate the effectiveness of ALA applied in several doses rather than a single dose in crush peripheral nerve injury models.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74670599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.02.045
M. Acar
{"title":"Boric acid's cytotoxic effect on CD133+ cancer stem cells in H460 cell line","authors":"M. Acar","doi":"10.5455/annalsmedres.2023.02.045","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.045","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77357659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.04.082
G. Lu, erif Kurtulu, Remzi Can, Hamdiye Turan, Z. Sak, Mahmut lger
Objective: This study aims to investigate the smoking status of teachers, the relationship between smoking and COPD, and teachers' awareness of COPD. Material and Method: 504 teachers participated in this cross-sectional study. The data was obtained through an online questionnaire utilizing a 22-question form designed by the researchers. Results: The mean age of the participants was 38.677.70 years, 47.8% of them were female, and 81.5% worked in public schools. 28% of teachers reported smoking. 24.4% of teachers reported living with a COPD patient, with 86.5% citing smoking as the major risk factor for COPD. 88.3% of participants indicated that avoiding tobacco products is crucial in preventing COPD. The majority of participants (92.7%) provided the correct response when asked about the symptoms of COPD. While 67.7% responded that PFT is used for diagnosis, 50.6% reported that it is a treatable disease, and 25% reported that inhaler medicines are used for treatment. There was a statistically significant distinction between the frequency of hearing about COPD and the specialties of the teachers. It was shown that 91.1% of smokers were aware of COPD, however, no statistical correlation was found between smoking and awareness. Conclusion: This study revealed that the prevalence of smoking among teachers in Sanliurfa was lower than previously reported in the literature. The level of awareness that COPD is a lung disease was found to be higher than in previous studies of a similar sort. It was established that awareness of the risk factors for COPD, its symptoms, preventive strategies, and the fact that COPD is a treatable disease was high. We believe that this awareness will play a crucial role in protecting students from smoking and various smoking-related diseases, such as COPD.
{"title":"Levels of teacher smoking and copd awareness: The case of Sanliurfa","authors":"G. Lu, erif Kurtulu, Remzi Can, Hamdiye Turan, Z. Sak, Mahmut lger","doi":"10.5455/annalsmedres.2023.04.082","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.04.082","url":null,"abstract":"Objective: This study aims to investigate the smoking status of teachers, the relationship between smoking and COPD, and teachers' awareness of COPD. Material and Method: 504 teachers participated in this cross-sectional study. The data was obtained through an online questionnaire utilizing a 22-question form designed by the researchers. Results: The mean age of the participants was 38.677.70 years, 47.8% of them were female, and 81.5% worked in public schools. 28% of teachers reported smoking. 24.4% of teachers reported living with a COPD patient, with 86.5% citing smoking as the major risk factor for COPD. 88.3% of participants indicated that avoiding tobacco products is crucial in preventing COPD. The majority of participants (92.7%) provided the correct response when asked about the symptoms of COPD. While 67.7% responded that PFT is used for diagnosis, 50.6% reported that it is a treatable disease, and 25% reported that inhaler medicines are used for treatment. There was a statistically significant distinction between the frequency of hearing about COPD and the specialties of the teachers. It was shown that 91.1% of smokers were aware of COPD, however, no statistical correlation was found between smoking and awareness. Conclusion: This study revealed that the prevalence of smoking among teachers in Sanliurfa was lower than previously reported in the literature. The level of awareness that COPD is a lung disease was found to be higher than in previous studies of a similar sort. It was established that awareness of the risk factors for COPD, its symptoms, preventive strategies, and the fact that COPD is a treatable disease was high. We believe that this awareness will play a crucial role in protecting students from smoking and various smoking-related diseases, such as COPD.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77768545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.01.017
E. Doğan, M. Ozkan, M. Inanc, U. Abdulrezzak, A. Tutuş, F. Ozturk, E. Sozuer, G. Sezgin, S. Gursoy, A. Yurçi, F. Bayram
Grade 3 gastroenteropancreatic neuroendocrine tumors (GEPNETs) are not a homogenous group. We aimed to determine clinicopathologic, survival and prognostic differences in metastatic grade 3 GEPNETs with the help of ki67 and GA68PET CT/octreoscan. We divided patients diagnosed metastatic grade 3 GEPNETs into two groups based on the ki67 cut-off point 47 as ki67 low and high. And we divided into 2 groups again according to scan positivity. And we compared all four groups according to clinicopathologic characteristics, survival and prognostic factors. We included 26 patients into our study. The median overall survival in low group was 20 and 10 months in high group (p=0,321). Lower ki67 scan positive group had longer overall survival than lower ki67 scan negative group (NR vs 3 months, respectively, p=0.067) and in high ki67 group the median overall survival was longer in scan positive than negative group (10 vs 9,respectively, p=0.956). The median overall survival was longer in patients with low ki67 levels compared to high ki67 levels. The best overall survival was in low ki67 and scan positive group.
{"title":"TWO DIFFERENT CHARACTERISTICS AND PROGNOSIS OF GRADE 3 GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS:\u0000Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience","authors":"E. Doğan, M. Ozkan, M. Inanc, U. Abdulrezzak, A. Tutuş, F. Ozturk, E. Sozuer, G. Sezgin, S. Gursoy, A. Yurçi, F. Bayram","doi":"10.5455/annalsmedres.2023.01.017","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.017","url":null,"abstract":"Grade 3 gastroenteropancreatic neuroendocrine tumors (GEPNETs) are not a homogenous group. We aimed to determine clinicopathologic, survival and prognostic differences in metastatic grade 3 GEPNETs with the help of ki67 and GA68PET CT/octreoscan. We divided patients diagnosed metastatic grade 3 GEPNETs into two groups based on the ki67 cut-off point 47 as ki67 low and high. And we divided into 2 groups again according to scan positivity. And we compared all four groups according to clinicopathologic characteristics, survival and prognostic factors. We included 26 patients into our study. The median overall survival in low group was 20 and 10 months in high group (p=0,321). Lower ki67 scan positive group had longer overall survival than lower ki67 scan negative group (NR vs 3 months, respectively, p=0.067) and in high ki67 group the median overall survival was longer in scan positive than negative group (10 vs 9,respectively, p=0.956). The median overall survival was longer in patients with low ki67 levels compared to high ki67 levels. The best overall survival was in low ki67 and scan positive group.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82776561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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