Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.01.07
Saf Zg, Emine N, Derya Tanriverd, Sevde Erol
Objective: This study was conducted to adapt the cardiac self-blame scale developed by Harry et al. in 2018 into Turkish. Materials and Methods: The sample of the study consisted of 125 patients with cardiovascular disease. Confirmatory (CFA)factor analyses were conducted to examine the construct validity of the scale and the correlation of it between similar scales was analyzed within the scope of criterion validity. As a result of confirmatory factor analysis, it was observed that the two-factor (Behavioral Self-Blame and Characterological Self-Blame) structure of the scale was preserved in the Turkish sample as well. Results: In the analysis performed for criterion-related validity, significant correlations were found between the scale and other scales (p<0.01). Conclusion: The findings obtained because of the validity and reliability studies of the cardiac self-blame attributions scale, which was adapted into Turkish, revealed can be used to determine the accusations against the behavior and characters of individuals with cardiac disease in Turkish society.
{"title":"Validity and Reliability of the Cardiac Self-Blame Attributions Scale in Turkish","authors":"Saf Zg, Emine N, Derya Tanriverd, Sevde Erol","doi":"10.5455/annalsmedres.2023.01.07","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.07","url":null,"abstract":"Objective: This study was conducted to adapt the cardiac self-blame scale developed by Harry et al. in 2018 into Turkish. Materials and Methods: The sample of the study consisted of 125 patients with cardiovascular disease. Confirmatory (CFA)factor analyses were conducted to examine the construct validity of the scale and the correlation of it between similar scales was analyzed within the scope of criterion validity. As a result of confirmatory factor analysis, it was observed that the two-factor (Behavioral Self-Blame and Characterological Self-Blame) structure of the scale was preserved in the Turkish sample as well. Results: In the analysis performed for criterion-related validity, significant correlations were found between the scale and other scales (p<0.01). Conclusion: The findings obtained because of the validity and reliability studies of the cardiac self-blame attributions scale, which was adapted into Turkish, revealed can be used to determine the accusations against the behavior and characters of individuals with cardiac disease in Turkish society.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"238 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86196425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.09.282
brahim ksel, Ali nda, M. Z., Mehmet ven
Aim: This retrospective study aimed to determine the incidence of random findings in digital panoramic images acquired from edentulous patients presenting for conventional prosthetic rehabilitations or implant-supported dentures. Materials and Methods: In this retrospective study, of the patients aged 16 years and older, 950 of 1100 panoramic films were evaluated by two maxillofacial radiologists (MA and IBY) in ambient light on an LCD monitor. The final classification and radiographic status of each finding were recorded after inter-observer consensus. Radiographs with low image quality and artifacts that did not include the demographic information of the patients were not included in the study. In the present study; impacted teeth, root remnants, radiolucent (RL) lesions, radiopaque (RO) lesions (including idiopathic osteosclerosis), foreign bodies, crest atrophies, soft tissue calcifications, maxillary sinus opacities, and Stafne bone defects were examined. Lesions affecting the alveolar region were divided into three regions as anterior (incisors and canines region), premolars and molars region. Results: Tonsillitis was observed in a total of 55 individuals, 26 men and 29 women. Sialolith was seen in a total of 3 patients, 2 male and 1 female, but phleboliths were not found in any of them. Styloid ligament ossification(SLO) was seen in a total of 125 patients, 69 of these cases were female and 56 were male, however calcified atherosclerotic plaque is the most common calcification with 156 individuals and a rate of 16.4% among calcifications. Laryngeal cartilage calcification, which is seen in 36 female and 23 male individuals. Conclusion: The outcome of this study indicated that the ratio of advantageous findings fixed in digital panoramic images of totally edentulous patients was highly rated. There are indispensable for patients with total edentulism such as routine use and careful examination of panoramic images.
{"title":"Evaluation of Panoramic Radiographs of Totally Edentulous Jaws: A Retrospective Study","authors":"brahim ksel, Ali nda, M. Z., Mehmet ven","doi":"10.5455/annalsmedres.2022.09.282","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.282","url":null,"abstract":"Aim: This retrospective study aimed to determine the incidence of random findings in digital panoramic images acquired from edentulous patients presenting for conventional prosthetic rehabilitations or implant-supported dentures. Materials and Methods: In this retrospective study, of the patients aged 16 years and older, 950 of 1100 panoramic films were evaluated by two maxillofacial radiologists (MA and IBY) in ambient light on an LCD monitor. The final classification and radiographic status of each finding were recorded after inter-observer consensus. Radiographs with low image quality and artifacts that did not include the demographic information of the patients were not included in the study. In the present study; impacted teeth, root remnants, radiolucent (RL) lesions, radiopaque (RO) lesions (including idiopathic osteosclerosis), foreign bodies, crest atrophies, soft tissue calcifications, maxillary sinus opacities, and Stafne bone defects were examined. Lesions affecting the alveolar region were divided into three regions as anterior (incisors and canines region), premolars and molars region. Results: Tonsillitis was observed in a total of 55 individuals, 26 men and 29 women. Sialolith was seen in a total of 3 patients, 2 male and 1 female, but phleboliths were not found in any of them. Styloid ligament ossification(SLO) was seen in a total of 125 patients, 69 of these cases were female and 56 were male, however calcified atherosclerotic plaque is the most common calcification with 156 individuals and a rate of 16.4% among calcifications. Laryngeal cartilage calcification, which is seen in 36 female and 23 male individuals. Conclusion: The outcome of this study indicated that the ratio of advantageous findings fixed in digital panoramic images of totally edentulous patients was highly rated. There are indispensable for patients with total edentulism such as routine use and careful examination of panoramic images.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77435266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.10.317
M. Erdoğan, E. Erdoğan
Aim: The COVID-19 has spread rapidly around the world. Apart from primarily targeting the lungs and causing acute respiratory distress syndrome with severe respiratory symptoms and high risk of death, the disease can also cause damage to other organs such as the heart, kidney, and testis. Studies have shown that men are more likely to get infected by the disease than women and the death rate due to the disease is found to be higher in men. We aimed to show the effects of COVID-19 on sperm parameters. Materials and Methods: In the study, semen analyzes of COVID-19 patients and healthy control groups were compared according to the presence or absence of PCR-confirmed SARS-CoV-2 positivity in hospital records. Patients with COVID-19 (+) were the patients who had mild disease. A total of 510 participants, 53 COVID-19 patients and 457 healthy control groups. After positivity confirmation of recovered COVID-19 patients using PCR, semen analysis was performed after an average of 157 (24-355) days. Also, in order to evaluate the short-term and long-term effects of the disease, patients were grouped as those with less than 90 days and more than 90 days after receiving the positive PCR result. Results: While the mean progressive motility of sperm was 41.45 (19.21) in the recovered COVID-19 patients, it was 38.35 (21.74) in the control group. The mean total motility was 55.74 (19.34) in recovered COVID-19 patients, where as it was 51.84 (22.45) in control group. The percentage of normal sperm morphology was 11.45 (5.97) in recovered COVID-19 patients, however it was 11.19 (8.08) in control group. The sperm concentration was found to be 68.60 (56.22) x 106/ml in recovered COVID-19 patients, but it was 74.10 (61.72) x 106/ml in control group. Finally, the mean sperm immobility was 44.26 (19.34) in recovered COVID-19 group, however it was 48.16 (22.45) in control group. Conclusion: In the study, when the semen analysis results of patients who recovered after COVID-19 and healthy control groups were compared in terms of semen parameters according to the recovery time period, no statistically significant difference was found. More studies are needed to fully understand the effects of COVID-19 on the reproductive system.
{"title":"Analysis of Semen Parameters of Recovered Patients after COVID-19","authors":"M. Erdoğan, E. Erdoğan","doi":"10.5455/annalsmedres.2022.10.317","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.317","url":null,"abstract":"Aim: The COVID-19 has spread rapidly around the world. Apart from primarily targeting the lungs and causing acute respiratory distress syndrome with severe respiratory symptoms and high risk of death, the disease can also cause damage to other organs such as the heart, kidney, and testis. Studies have shown that men are more likely to get infected by the disease than women and the death rate due to the disease is found to be higher in men. We aimed to show the effects of COVID-19 on sperm parameters. Materials and Methods: In the study, semen analyzes of COVID-19 patients and healthy control groups were compared according to the presence or absence of PCR-confirmed SARS-CoV-2 positivity in hospital records. Patients with COVID-19 (+) were the patients who had mild disease. A total of 510 participants, 53 COVID-19 patients and 457 healthy control groups. After positivity confirmation of recovered COVID-19 patients using PCR, semen analysis was performed after an average of 157 (24-355) days. Also, in order to evaluate the short-term and long-term effects of the disease, patients were grouped as those with less than 90 days and more than 90 days after receiving the positive PCR result. Results: While the mean progressive motility of sperm was 41.45 (19.21) in the recovered COVID-19 patients, it was 38.35 (21.74) in the control group. The mean total motility was 55.74 (19.34) in recovered COVID-19 patients, where as it was 51.84 (22.45) in control group. The percentage of normal sperm morphology was 11.45 (5.97) in recovered COVID-19 patients, however it was 11.19 (8.08) in control group. The sperm concentration was found to be 68.60 (56.22) x 106/ml in recovered COVID-19 patients, but it was 74.10 (61.72) x 106/ml in control group. Finally, the mean sperm immobility was 44.26 (19.34) in recovered COVID-19 group, however it was 48.16 (22.45) in control group. Conclusion: In the study, when the semen analysis results of patients who recovered after COVID-19 and healthy control groups were compared in terms of semen parameters according to the recovery time period, no statistically significant difference was found. More studies are needed to fully understand the effects of COVID-19 on the reproductive system.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85734272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Iron deficiency anemia (IDA) is a significant health problem in pregnant women. We aimed to evaluate the effect of gestational IDA and to compare the results of iron therapy in pregnant women. Methods: This retrospective cohort study of pregnant women in the third trimester analyzed the records of 63 women not taking any iron supplements, 70 women receiving intravenous ferric carboxymaltose therapy (FCM), and 73 pregnant women receiving oral iron therapy. It compared maternal and neonatal outcomes of the three groups. Results: The mean age of the 206 pregnant women included in the study was 29.19±4.34 (19-44; min–max). Only 1% of anemic women received a blood transfusion in the postpartum period. There was no difference between the groups' mean age and gestational week. The median values of gravida and parity were the same in all 3 groups (Gravida=2, Parity=1). Maternal hemoglobin (Hb) value of the non-iron group was lower than that of the other groups (p<0.001). Although the mothers' Hb levels at birth were different, the newborns' Hb values were not affected (p=0.547). Neonatal height and weight were lower in the non-iron group than in the FCM and oral iron groups (p=0.048 and p<0.001, respectively). Neonatal head circumference, 1-minute Apgar, and 5-minute Apgar scores were similar in all three groups. Conclusion: FCM is effective in pregnant women with IDA in late pregnancy and women undergoing this treatment deliver healthier newborns.
{"title":"What is the best treatment for anemia in pregnant women in the third trimester: Ferric carboxymaltose or oral iron therapy?","authors":"Elif Eren, Yakup Karakurt, Sevil Sadri, Gamze Demirel","doi":"10.5455/annalsmedres.2023.09.246","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.09.246","url":null,"abstract":"Objective: Iron deficiency anemia (IDA) is a significant health problem in pregnant women. We aimed to evaluate the effect of gestational IDA and to compare the results of iron therapy in pregnant women. Methods: This retrospective cohort study of pregnant women in the third trimester analyzed the records of 63 women not taking any iron supplements, 70 women receiving intravenous ferric carboxymaltose therapy (FCM), and 73 pregnant women receiving oral iron therapy. It compared maternal and neonatal outcomes of the three groups. Results: The mean age of the 206 pregnant women included in the study was 29.19±4.34 (19-44; min–max). Only 1% of anemic women received a blood transfusion in the postpartum period. There was no difference between the groups' mean age and gestational week. The median values of gravida and parity were the same in all 3 groups (Gravida=2, Parity=1). Maternal hemoglobin (Hb) value of the non-iron group was lower than that of the other groups (p<0.001). Although the mothers' Hb levels at birth were different, the newborns' Hb values were not affected (p=0.547). Neonatal height and weight were lower in the non-iron group than in the FCM and oral iron groups (p=0.048 and p<0.001, respectively). Neonatal head circumference, 1-minute Apgar, and 5-minute Apgar scores were similar in all three groups. Conclusion: FCM is effective in pregnant women with IDA in late pregnancy and women undergoing this treatment deliver healthier newborns.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.213
Bet l, Eylem Ate, Serhat l, Nisa larslan, Dilek Konuksever, Bet Ulukol
Aim: Sharenting, the act of parents sharing content related to their children on social media, has become a prevalent practice in today's digital age. However, concerns have been raised about the potential privacy violations and risks that this behavior may expose children to. This study aimed to investigate sharenting behaviors among Turkish parents and validate the Turkish version of the Sharenting Evaluation Scale (SES). Materials and methods: Following World Health Organization guidelines, the original SES was translated into Turkish. The scale's content validity was evaluated by experts before being administered to 276 Turkish parents. Results: The overall reliability of the scale was determined to be 0.855, which indicates its strong reliability. To further enhance the scale's reliability, the tenth item was removed after examining item-total statistics, resulting in an improved Cronbach's alpha of 0.87 for the total scale. Subscale reliability was also satisfactory, with values of 0.92 for implications, 0.64 for social behavior, and 0.68 for self-control. Confirmatory Factor Analysis (CFA) was employed to assess the construct validity of the scale. The chi-square test indicated a significant fit (p<0.001, chi-square/df = 241.1/100 = 2.411), supporting the scale's reliability and measurement ability. Conclusion: The Turkish version of the 16-item SES demonstrated good reliability and validity, making it a valuable tool for assessing sharenting behaviors among Turkish parents. By utilizing this scale, healthcare professionals and researchers can gain crucial insights into parental sharing practices on social media and better understand the potential risks and implications for children's privacy and safety.
{"title":"Measuring Sharenting Behavior: Validity and Reliability of the Turkish Version of the Sharenting Evaluation Scale","authors":"Bet l, Eylem Ate, Serhat l, Nisa larslan, Dilek Konuksever, Bet Ulukol","doi":"10.5455/annalsmedres.2023.08.213","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.213","url":null,"abstract":"Aim: Sharenting, the act of parents sharing content related to their children on social media, has become a prevalent practice in today's digital age. However, concerns have been raised about the potential privacy violations and risks that this behavior may expose children to. This study aimed to investigate sharenting behaviors among Turkish parents and validate the Turkish version of the Sharenting Evaluation Scale (SES). Materials and methods: Following World Health Organization guidelines, the original SES was translated into Turkish. The scale's content validity was evaluated by experts before being administered to 276 Turkish parents. Results: The overall reliability of the scale was determined to be 0.855, which indicates its strong reliability. To further enhance the scale's reliability, the tenth item was removed after examining item-total statistics, resulting in an improved Cronbach's alpha of 0.87 for the total scale. Subscale reliability was also satisfactory, with values of 0.92 for implications, 0.64 for social behavior, and 0.68 for self-control. Confirmatory Factor Analysis (CFA) was employed to assess the construct validity of the scale. The chi-square test indicated a significant fit (p<0.001, chi-square/df = 241.1/100 = 2.411), supporting the scale's reliability and measurement ability. Conclusion: The Turkish version of the 16-item SES demonstrated good reliability and validity, making it a valuable tool for assessing sharenting behaviors among Turkish parents. By utilizing this scale, healthcare professionals and researchers can gain crucial insights into parental sharing practices on social media and better understand the potential risks and implications for children's privacy and safety.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.229
Bilge r, Serkan k, g cel, meral karada
Background and Aim: Our study aimed to find the relationship between MPV (Mean Platelet Volume) levels, a marker of inflammation, and platelet counts between simple and complex febrile seizures. Materials and Methods: In this retrospective comparative study, we analyzed the records of 283 children between the ages of 6 months and 6 years who were diagnosed with simple and complex febrile seizures (BFN/CFN) in the Pediatric Neurology Clinic of XXX University, Faculty of Medicine between January 2021 and December 2022. Results: The mean age and gender characteristics of the patients were similar in both groups. The MPV of the CFN group (69 patients) (6.53±0.39fl) was lower than that of the BFN group (214 patients) (7.81±0.43fl) and this difference was statistically significant (p<0.01). The platelet count of the CFN group (257.42×103±126.01×103) was higher than that of the BFN group (191.23×103±68.29×103) and the difference was statistically significant (p<0.01). Conclusion: There was a significant difference between BFN and CFN groups in terms of both MPV values and platelet counts. This study suggests that detailed and comprehensive studies on MPV and platelet counts may guide cases where clinical findings are suspicious and the distinction between BFN and CFN cannot be clearly differentiated.
{"title":"The Role of Mean Platelet Volume/Platelet Count in Differentiation of Simple and Complex Febrile Seizures","authors":"Bilge r, Serkan k, g cel, meral karada","doi":"10.5455/annalsmedres.2023.08.229","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.229","url":null,"abstract":"Background and Aim: Our study aimed to find the relationship between MPV (Mean Platelet Volume) levels, a marker of inflammation, and platelet counts between simple and complex febrile seizures. Materials and Methods: In this retrospective comparative study, we analyzed the records of 283 children between the ages of 6 months and 6 years who were diagnosed with simple and complex febrile seizures (BFN/CFN) in the Pediatric Neurology Clinic of XXX University, Faculty of Medicine between January 2021 and December 2022. Results: The mean age and gender characteristics of the patients were similar in both groups. The MPV of the CFN group (69 patients) (6.53±0.39fl) was lower than that of the BFN group (214 patients) (7.81±0.43fl) and this difference was statistically significant (p<0.01). The platelet count of the CFN group (257.42×103±126.01×103) was higher than that of the BFN group (191.23×103±68.29×103) and the difference was statistically significant (p<0.01). Conclusion: There was a significant difference between BFN and CFN groups in terms of both MPV values and platelet counts. This study suggests that detailed and comprehensive studies on MPV and platelet counts may guide cases where clinical findings are suspicious and the distinction between BFN and CFN cannot be clearly differentiated.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.05.122
Semiha Nur Ozkaya, Tuba Keskin, Ç. Tekin, S. Tekin, A. Beytur
Objective: Inflammation is a process associated with the development and progression of cancer. Desloratadine (DES) and Trimebutin (TMB) are anti-inflammatory agents used in the treatment of various diseases. This study aimed to investigate the antitumor effects of DES and TMB, which exhibit anti-inflammatory effects, on different human cancer cell lines. Materials and Methods: In this study, human prostate (LNCaP), ovarian (A2780), breast (MCF-7) and colon cancer (Caco-2) cell lines were treated with DES and TMB at concentrations of 1, 5, 25, 50 and 100 µM. Cells were treated with the compounds for 6, 12, and 24 hours, and the change in cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration 50 (LogIC50) values of the compounds were calculated using GraphPad Prism 8 software based on cell viability results. The genotoxic effects of the compounds on cells were determined using the comet assay. Group comparisons were performed using the Kruskal-Wallis H test and p<0.05 was considered significant. Results: Exposure of LNCaP, A2780, MCF-7, and Caco-2 cells to DES and TMB agents for 6, 12 and 24 hours significantly reduced cell viability (p≤0.05). According to the comet assay results, DES and TMB caused significant DNA damage in the cell lines (p≤0.05). Conclusion: The study results demonstrate that DES and TMB, which have anti-inflammatory effects, exert cytotoxic effects by inducing DNA damage in cancer cells.
{"title":"Investigation of the Antitumor Effects of Anti-inflammatory Desloratadine and Trimebutine on Different Types of Human Cancer Cells: An In Vitro study","authors":"Semiha Nur Ozkaya, Tuba Keskin, Ç. Tekin, S. Tekin, A. Beytur","doi":"10.5455/annalsmedres.2023.05.122","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.122","url":null,"abstract":"Objective: Inflammation is a process associated with the development and progression of cancer. Desloratadine (DES) and Trimebutin (TMB) are anti-inflammatory agents used in the treatment of various diseases. This study aimed to investigate the antitumor effects of DES and TMB, which exhibit anti-inflammatory effects, on different human cancer cell lines. Materials and Methods: In this study, human prostate (LNCaP), ovarian (A2780), breast (MCF-7) and colon cancer (Caco-2) cell lines were treated with DES and TMB at concentrations of 1, 5, 25, 50 and 100 µM. Cells were treated with the compounds for 6, 12, and 24 hours, and the change in cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration 50 (LogIC50) values of the compounds were calculated using GraphPad Prism 8 software based on cell viability results. The genotoxic effects of the compounds on cells were determined using the comet assay. Group comparisons were performed using the Kruskal-Wallis H test and p<0.05 was considered significant. Results: Exposure of LNCaP, A2780, MCF-7, and Caco-2 cells to DES and TMB agents for 6, 12 and 24 hours significantly reduced cell viability (p≤0.05). According to the comet assay results, DES and TMB caused significant DNA damage in the cell lines (p≤0.05). Conclusion: The study results demonstrate that DES and TMB, which have anti-inflammatory effects, exert cytotoxic effects by inducing DNA damage in cancer cells.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.10.316
Ece Yiğit
Aim: The aim of the study was to analyze the effect of probiotics on quality of life and depressive symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS) and moderate or severe depressive mood. Materials and Methods: Patients diagnosed with diarrhea-predominant IBS using ROMA IV criteria and Bristol Stool Scale and moderate or severe depressive symptoms using the Beck Depression Inventory comprised the study participants. The patients were randomized and divided into two groups as the medication only group and the medication+probiotic group. IBS 36 questionnaire and Beck's Depression Inventory were administered to all patients in the first and second groups and the scores were recorded. Results: The change in IBS-36 scores from the beginning to the 10th week was significant in both groups (p<0.001). According to IBS-36 the median change from the beginning to the 10th week was 32 for the medication group, this difference was 48 for the medication+probiotic group. The difference was statistically significant (p<0.001). The change in Beck’s Depression Inventory scores from the beginning to the 10th week was significant in both the medication group and the medication+probiotic group (p<0.001). According to the Beck’s Depression Inventory the median change from the beginning to the 10th week was 7 for the medication group, this difference was 9.5 for the medication+probiotic group. The difference was statistically significant (p<0.001). Conclusion: In the treatment of diarrhea-predominant IBS patients, the use of probiotics together with classical drugs will improve quality of life by reducing both gastrointestinal symptoms and psychological symptoms.
{"title":"The Effect of Probiotic Therapy on Quality of Life and Depressive Symptoms in Patients with Diarrhea-Predominant Irritable Bowel Syndrome","authors":"Ece Yiğit","doi":"10.5455/annalsmedres.2022.10.316","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.316","url":null,"abstract":"Aim: The aim of the study was to analyze the effect of probiotics on quality of life and depressive symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS) and moderate or severe depressive mood. Materials and Methods: Patients diagnosed with diarrhea-predominant IBS using ROMA IV criteria and Bristol Stool Scale and moderate or severe depressive symptoms using the Beck Depression Inventory comprised the study participants. The patients were randomized and divided into two groups as the medication only group and the medication+probiotic group. IBS 36 questionnaire and Beck's Depression Inventory were administered to all patients in the first and second groups and the scores were recorded. Results: The change in IBS-36 scores from the beginning to the 10th week was significant in both groups (p<0.001). According to IBS-36 the median change from the beginning to the 10th week was 32 for the medication group, this difference was 48 for the medication+probiotic group. The difference was statistically significant (p<0.001). The change in Beck’s Depression Inventory scores from the beginning to the 10th week was significant in both the medication group and the medication+probiotic group (p<0.001). According to the Beck’s Depression Inventory the median change from the beginning to the 10th week was 7 for the medication group, this difference was 9.5 for the medication+probiotic group. The difference was statistically significant (p<0.001). Conclusion: In the treatment of diarrhea-predominant IBS patients, the use of probiotics together with classical drugs will improve quality of life by reducing both gastrointestinal symptoms and psychological symptoms.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89312956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.233
Tu lar, Berna n
Objective: Celiac is a small intestine disease that occurs in susceptible individuals with a cellular and humoral immunological response that develops against gluten, a cereal protein. There are few studies evaluating the audiovestibular system in celiac patients. This study aims to evaluate audiovestibular findings in celiac patients. Materials and Methods: 40 patients with celiac disease and 40 healthy volunteers were enrolled in this sudy. Each subject underwent a neurotologic examination including pure tone audiometry (PTA), Transient Evoked Otoacoustic Emission (TEOAE) with 1000 Hz, 1500 Hz, 2000 Hz, 3000 Hz and 4000 Hz, Videonystagmography (VNG), and binaural bithermal caloric test. It was evaluated whether the test results indicated significant differences between the celiac patient and control group. Results: Sensorineural hearing loss was detected in the right and left ear of the 7 patients. In the pure tone audiometry (PTA) test, there was no statistically significant difference between celiac patients and controls in both air conducted and bone conducted hearing thresholds (p=0,389 for the right ear, p=0,083 for the left ear). Speech reception thresholds of celiac patients were significantly higher than the controls (p= 0,000 for right ear, p=0,001 for the left ear) While OAE response was obtained in the right ear of 24 patients and in the left ear of 23 patients; OAE response was obtained in all of the control group. In the OAE test, in response to 2000 Hz stimuli, there was no significant difference in the right ear responses, although there was a lower signal-to-noise ratio in patients compared to the control group. At all other frequencies, a statistically significant lower signal-to-noise ratio was found in the patient group. Statistically significant pathological differences were found in spontaneaus nystagmus, gaze, saccade, smooth pursuit, optokinetic nystagmus and caloric tests in celiac patients compared to the control group (p < 0.05). Conclusion: Pure tone audiometry, otoacoustic emision, oculomotor and caloric tests findings indicated that auditory system, periphral and central vestibular system may be affected in individuals with celiac disease.
{"title":"Audiovestibular Findings in Celiac Patients","authors":"Tu lar, Berna n","doi":"10.5455/annalsmedres.2022.08.233","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.233","url":null,"abstract":"Objective: Celiac is a small intestine disease that occurs in susceptible individuals with a cellular and humoral immunological response that develops against gluten, a cereal protein. There are few studies evaluating the audiovestibular system in celiac patients. This study aims to evaluate audiovestibular findings in celiac patients. Materials and Methods: 40 patients with celiac disease and 40 healthy volunteers were enrolled in this sudy. Each subject underwent a neurotologic examination including pure tone audiometry (PTA), Transient Evoked Otoacoustic Emission (TEOAE) with 1000 Hz, 1500 Hz, 2000 Hz, 3000 Hz and 4000 Hz, Videonystagmography (VNG), and binaural bithermal caloric test. It was evaluated whether the test results indicated significant differences between the celiac patient and control group. Results: Sensorineural hearing loss was detected in the right and left ear of the 7 patients. In the pure tone audiometry (PTA) test, there was no statistically significant difference between celiac patients and controls in both air conducted and bone conducted hearing thresholds (p=0,389 for the right ear, p=0,083 for the left ear). Speech reception thresholds of celiac patients were significantly higher than the controls (p= 0,000 for right ear, p=0,001 for the left ear) While OAE response was obtained in the right ear of 24 patients and in the left ear of 23 patients; OAE response was obtained in all of the control group. In the OAE test, in response to 2000 Hz stimuli, there was no significant difference in the right ear responses, although there was a lower signal-to-noise ratio in patients compared to the control group. At all other frequencies, a statistically significant lower signal-to-noise ratio was found in the patient group. Statistically significant pathological differences were found in spontaneaus nystagmus, gaze, saccade, smooth pursuit, optokinetic nystagmus and caloric tests in celiac patients compared to the control group (p < 0.05). Conclusion: Pure tone audiometry, otoacoustic emision, oculomotor and caloric tests findings indicated that auditory system, periphral and central vestibular system may be affected in individuals with celiac disease.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89328519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.12.397
D. Turkmen, Talat c, Hacer Karatoprak
{"title":"Retrospective analysis of the frequency and variety of skin lesions in patients diagnosed with sarcoidosis and examined by dermatology in a tertiary health care facility","authors":"D. Turkmen, Talat c, Hacer Karatoprak","doi":"10.5455/annalsmedres.2022.12.397","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.397","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84289642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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