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Incidental cause of mild hyperglycemia in children: genetic, clinical, and follow-up features of Glucokinase-MODY diabetes 儿童轻度高血糖的偶然原因:葡萄糖激酶-MODY 型糖尿病的遗传、临床和随访特征
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.11.332
smail ndar
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引用次数: 0
The Psychosocial Well-being of Children with Fragile X Syndrome: Psychopathology, Autism Spectrum Disorder Comorbidity and the Role of Caregivers' Perceived Social Support 脆性X综合征儿童的心理社会健康:精神病理学、自闭症谱系障碍共病及照顾者感知社会支持的作用
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.09.297
A. M. Res, Hicran Doğru, Yuce Kahraman
Objective: Fragile X syndrome (FXS) is a rare genetic disease that can have several intellectual and developmental disabilities. Here, we aim to examine psychopathology in children with FXS and investigate the relationship between children's psychosocial well-being and socio-demographic factors, autism spectrum disorder (ASD) comorbidity, and the type and level of caregivers' perceived social support. Materials and Method: Twenty-six children aged 5-18 years with FXS and 26 age- and sex-matched healthy controls (HC) were included. DSM-5-based clinical interviews were conducted with all participants. We also collected parent ratings of health-related quality of life indexes and perceived social support levels and types. Results: The mean age of children with FXS was 10.9 ± 3.5 years, and the mean age of healthy comparisons (HC, n= 26) was 11.8 ± 2.6 years. In the FXS group, 84.6% had comorbid psychiatric disorders, and 65.3% had intellectual disability. FXS group displayed lower psychosocial and total quality of life scores than the HC group. Also, there was significant positive correlations between childrens' psychosocial well-being and "significant others" (rp = 0.502, p = 0.009) and total perceived support scores (rp = 0.448, p = 0.022). The most influential factor related to the psychosocial well-being in children with FXS was ASD comorbidity (F= 30.6, R2, 0.543, p<0.001). Conclusion: Providing support to mothers of children with FXS may positively affect the children's health outcomes, especially psychosocial well-being.
目的:脆性X染色体综合征(FXS)是一种罕见的遗传性疾病,可导致多种智力和发育障碍。本研究旨在研究FXS儿童的心理病理,探讨儿童心理社会健康与社会人口统计学因素、自闭症谱系障碍(ASD)共病、照顾者感知社会支持类型和水平的关系。材料与方法:纳入26例5-18岁FXS患儿和26例年龄与性别匹配的健康对照(HC)。对所有参与者进行基于dsm -5的临床访谈。我们还收集了父母对健康相关生活质量指数和感知社会支持水平和类型的评分。结果:FXS患儿的平均年龄为10.9±3.5岁,健康对照(HC, n= 26)的平均年龄为11.8±2.6岁。在FXS组中,84.6%患有共病性精神障碍,65.3%患有智力残疾。FXS组的社会心理和总生活质量得分低于HC组。此外,儿童心理社会幸福感与“重要他人”(rp = 0.502, p = 0.009)和总感知支持得分(rp = 0.448, p = 0.022)之间存在显著正相关。影响FXS患儿心理社会健康的最主要因素是ASD合并症(F= 30.6, R2, 0.543, p<0.001)。结论:为FXS儿童的母亲提供支持可能会对儿童的健康状况产生积极影响,尤其是心理社会健康。
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引用次数: 0
The effect of lifestyle change on autonomic nervous system dysfunction in patients with metabolic syndrome 生活方式改变对代谢综合征患者自主神经系统功能障碍的影响
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.04.150
A. Birant, G. Kozdağ, D. Ural, A. Ağır
Study Design: A prospective clinical cohort study. Objective: In this study, it was aimed to examine the effects of metabolic syndrome, which affects many organs, on the autonomic nervous system and to observe the changes after treatment. Materials and Methods: Heart rate variability values of 101 metabolic syndrome patients who were treated at the Kocaeli University Cardiology Outpatient Clinic included in the study. All patients were offered lifestyle change suggestions in addition to their medical treatments. At the end of three months, the heart rate variability parameters of the patients were re-evaluated. Results: Heart rate variability values were found to be significantly lower in metabolic syndrome patients compared to the control group. It was observed that the heart rate variability values improved significantly in half of the patients who applied the given treatment with lifestyle changes. A decrease in heart rate change parameters was found in the group that did not implement lifestyle changes compared to the beginning of the study. Conclusions: Autonomic nervous system functions evaluated by heart rate variability decreased in patients with metabolic syndrome, and the treatment and lifestyle changes had a positive effect on these parameters.
研究设计:前瞻性临床队列研究。目的:本研究旨在探讨影响多脏器的代谢综合征对自主神经系统的影响,并观察治疗后的变化。材料和方法:纳入研究的101例在Kocaeli大学心脏病学门诊接受治疗的代谢综合征患者的心率变异性值。所有患者除了接受药物治疗外,还接受了改变生活方式的建议。3个月后,重新评估患者心率变异性参数。结果:与对照组相比,代谢综合征患者的心率变异性值明显降低。我们观察到,在接受了改变生活方式的治疗的患者中,有一半的患者心率变异性值得到了显著改善。与研究开始时相比,没有改变生活方式的那一组的心率变化参数有所下降。结论:代谢综合征患者心率变异性评价的自主神经系统功能下降,治疗和生活方式的改变对这些参数有积极影响。
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引用次数: 0
The Effect of Natural Antioxidant Levels in Pregnancy on Birth Weight 孕期天然抗氧化剂水平对出生体重的影响
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.12.395
A. M. Res, Ahmet Ziya Şahi̇n, Ç. Demiroğlu
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引用次数: 0
TWO DIFFERENT CHARACTERISTICS AND PROGNOSIS OF GRADE 3 GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS:Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience 3级胃肠胰神经内分泌肿瘤的两种不同特征及预后:ercies多学科神经内分泌肿瘤(NET)组经验
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.017
E. Doğan, M. Ozkan, M. Inanc, U. Abdulrezzak, A. Tutuş, F. Ozturk, E. Sozuer, G. Sezgin, S. Gursoy, A. Yurçi, F. Bayram
Grade 3 gastroenteropancreatic neuroendocrine tumors (GEPNETs) are not a homogenous group. We aimed to determine clinicopathologic, survival and prognostic differences in metastatic grade 3 GEPNETs with the help of ki67 and GA68PET CT/octreoscan. We divided patients diagnosed metastatic grade 3 GEPNETs into two groups based on the ki67 cut-off point 47 as ki67 low and high. And we divided into 2 groups again according to scan positivity. And we compared all four groups according to clinicopathologic characteristics, survival and prognostic factors. We included 26 patients into our study. The median overall survival in low group was 20 and 10 months in high group (p=0,321). Lower ki67 scan positive group had longer overall survival than lower ki67 scan negative group (NR vs 3 months, respectively, p=0.067) and in high ki67 group the median overall survival was longer in scan positive than negative group (10 vs 9,respectively, p=0.956). The median overall survival was longer in patients with low ki67 levels compared to high ki67 levels. The best overall survival was in low ki67 and scan positive group.
3级胃肠胰腺神经内分泌肿瘤(GEPNETs)不是一个同质组。我们的目的是在ki67和GA68PET CT/ octrescan的帮助下确定转移性3级GEPNETs的临床病理、生存和预后差异。我们将诊断为转移性3级GEPNETs的患者根据ki67截断点47分为ki67低和高两组。根据扫描阳性情况再次分为2组。根据临床病理特征、生存率及预后因素对四组患者进行比较。我们在研究中纳入了26名患者。低组中位总生存期为20个月,高组中位总生存期为10个月(p=0,321)。低ki67扫描阳性组总生存期长于低ki67扫描阴性组(分别为3个月,p=0.067),高ki67扫描阳性组中位总生存期长于阴性组(分别为10个月和9个月,p=0.956)。与高ki67水平患者相比,低ki67水平患者的中位总生存期更长。低ki67组和扫描阳性组总生存率最高。
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引用次数: 0
OUR RESULTS OF TOTAL HIP ARTROPLASTY WITH ANTEROLATERAL APPROACH 前外侧入路全髋关节置换术的结果
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.013
Enes z, R. Sevimli, Harun se
Aim: It was aimed to compare the clinical and radiological results of total hip arthroplasty performed with the anterolateral approach with the literature. Material and Method: 65 patients who underwent total hip arthroplasty with anterolateral approach between 2016-2021 were included. Preoperative and postoperative functional status evaluations of the patients were performed using the Harris hip score. In the clinical evaluation of the patients, thigh pain, wound infection, length of hospital stay, body mass index, duration of surgery and complications were also evaluated. In the radiological evaluation, the acetabular and femoral relaxation zones, the presence and amount of vertical and horizontal migration of the acetabular component, the presence and amount of femoral vertical migration, the position of the femoral component, the femoral dorr classification, the angle of inclination of the acetabular component and the presence of heterotrophic ossification were examined. Results: Of the patients, 29 (44.6%) were male and 36 (55.4%) were female. The mean age of the patients was 61.65 and the mean follow-up period was 40.2 months. Considering the diagnoses of the patients, THA was applied to 51 (70.8%) patients for coxarthrosis, 14 (19.4%) for avascular necrosis, 5 (6.9%) patients for fractures, and 2 (2.8%) patients for septic arthritis. The mean preoperative Harris Hip Score of the patients was 34.2 (18.1-59.9). The mean postoperative Harris Hip score was 88.5 (68.8-96). When the postoperative Harris Hip Score of the patients was evaluated, 53 (73.6%) were evaluated as excellent results, 18 (25%) as very good results, and 1 (1.4%) as good result. Findings: In our study, the results of total hip arthroplasty performed with the anterolateral approach were found to be a successful and satisfactory surgery when performed with appropriate indications and planning.
目的:比较前外侧入路全髋关节置换术的临床和影像学结果与文献资料。材料和方法:纳入2016-2021年间行前外侧入路全髋关节置换术的65例患者。术前和术后功能状态评估采用Harris髋关节评分。在临床评价中,还对患者的大腿疼痛、伤口感染、住院时间、体重指数、手术时间和并发症进行了评价。在放射学评估中,检查了髋臼和股骨松弛区、髋臼组件垂直和水平移动的存在和量、股垂直移动的存在和量、股组件的位置、股背分类、髋臼组件的倾斜角和异养骨化的存在。结果:男性29例(44.6%),女性36例(55.4%)。患者平均年龄61.65岁,平均随访时间40.2个月。考虑到患者的诊断,关节关节病51例(70.8%),缺血性坏死14例(19.4%),骨折5例(6.9%),脓毒性关节炎2例(2.8%)。患者术前Harris髋关节评分平均值为34.2(18.1-59.9)。术后Harris髋关节平均评分为88.5(68.8-96)。在对患者进行术后Harris髋关节评分时,53例(73.6%)评价为优秀,18例(25%)评价为非常好,1例(1.4%)评价为良好。结果:在我们的研究中,采用前外侧入路进行全髋关节置换术的结果发现,在适当的适应症和计划下进行手术是成功和令人满意的。
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引用次数: 1
Association of hyperchloremia with acute kidney injury in children with major trauma 高胆红素血症与重大创伤儿童急性肾损伤的关系
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.11.347
A. M. Res, Kübra Çeleğen, M. Çeleğen
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引用次数: 0
Investigation of the Dose-Dependent Effect of Carminic Acid on Brain and Peripheral Tissues Carminic Acid对脑及外周组织剂量依赖性的研究
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.12.360
G. Akcay
In recent years, there has been an increase in the frequency of use of food additives and colorants to extend the life of food and to color it. Excessive consumption of these additives can lead to attention deficit hyperactivity disorder and learning disorder, especially in children. Uncontrolled additives whose dosage is not specified can cause an allergic reaction, cause damage to the neurological system and cause cancer. There are not many studies showing the dose-dependent effect of carminic acid. It was aimed to determine the dose-dependent changes of carminic acid, a food additive, in liver, kidney, blood and brain tissues (hippocampus, brain, brain stem) and to investigate the effects of these doses on hyperactivity behaviorally. In our study, dose-dependent effects of 500 mg, 1500 mg and 3000 mg carminic acid (CA) used as a colorant in hippocampus, brain, brain stem, liver, kidney and blood samples were investigated. 32 Wistar albino male rats weighing 150-200 g were divided into 4 groups as control, CA-500, CA-1500 and CA-3000. The locomotor activities of the rats were evaluated in the open field test, and their anxiety behaviors were evaluated in the elevated plus maze test. Carminic acid levels in hippocampus, brain, brain stem, liver, kidney and blood were measured by high performance liquid chromatography (HPLC) method. Locomotor activity and anxiety behavior test results of CA-1500 and CA-3000 groups were increased compared to the control group. In the results of HPLC analysis, 500 mg, 1500 mg and 3000 mg doses administered to rats were not detectable in hippocampus, brain and brain stem tissues, while a dose-dependent increase was found in liver, kidney and blood samples (p<0.5). It was concluded that since carminic acid could not cross the blood-brain barrier, it was not detected in hippocampus, brain and brain stem tissues, and increased dose-dependently in peripheral tissues such as liver, kidney and blood. Although it cannot be detected in the brain, it has been observed that hyperactivity, which may increase locomotor activity and anxiety, may lead to behavioral changes.
近年来,人们越来越频繁地使用食品添加剂和着色剂来延长食品的寿命和给食品上色。过量食用这些添加剂会导致注意力缺陷多动障碍和学习障碍,尤其是儿童。未指定剂量的不受控制的添加剂会引起过敏反应,对神经系统造成损害并导致癌症。没有多少研究显示卡己酸的剂量依赖性。目的是确定一种食品添加剂胭脂红酸在肝脏、肾脏、血液和脑组织(海马、脑、脑干)中的剂量依赖性变化,并研究这些剂量对多动症行为的影响。本研究考察了500 mg、1500 mg和3000 mg胭脂红酸(CA)作为着色剂在海马、脑、脑干、肝脏、肾脏和血液中的剂量依赖性。取体重150 ~ 200 g的Wistar白化雄性大鼠32只,分为对照组、CA-500组、CA-1500组和CA-3000组。采用开阔场试验评价大鼠的运动活动,采用升高+迷宫试验评价大鼠的焦虑行为。采用高效液相色谱法测定大鼠海马、脑、脑干、肝、肾及血液中胭脂红酸的含量。CA-1500组和CA-3000组的运动活动和焦虑行为测试结果均较对照组升高。HPLC分析结果显示,500mg、1500mg和3000mg给药大鼠海马、脑和脑干组织中均未检测到剂量,而肝脏、肾脏和血液样品中均呈剂量依赖性增加(p<0.5)。综上所述,由于carminic acid不能穿过血脑屏障,因此在海马、脑和脑干组织中均未检测到carminic acid,而在肝、肾和血液等外周组织中则呈剂量依赖性增加。虽然它不能在大脑中检测到,但已经观察到,多动症可能会增加运动活动和焦虑,可能导致行为改变。
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引用次数: 0
Clinicopathological analysis of conjunctival lesions: An experience from the eastern part of Turkey 结膜病变的临床病理分析:土耳其东部地区的经验
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.09
A. Akatlı, S. Dikci
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引用次数: 0
Complete Title: Assessment of optic disc and macula in fasting period during Ramadan by optical coherence tomography angiographyRunning Title: Evaluating the effect of fasting by OCT-A 完整标题:通过光学相干断层血管造影评估斋月禁食期间的视盘和黄斑运行标题:通过光学相干断层血管造影评估禁食的影响
Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.08.228
N. Bilen, Meltem l
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引用次数: 0
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Annals of Medical Research
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