Aim: This study examined inflammation markers and electrocardiogram data in patients with first-episode mania (FEM). It aimed to examine the inflammation processes in the early stages of the disease and the frontal QRS-T (fQRS-T) angle in bipolar disorder (BD). Materials and Methods: After exclusion criteria, 53 FEM patients and 59 healthy controls (HC) were included in the study. Sociodemographic, electrocardiogram (ECG) and lab data of the participants were evaluated. Results: Mean of age and gender distribution did not differ between the groups (p=.743, p=.294, respectively). The heart rate of the FEM group was significantly higher than the HC group (p<.001). fQRS-T was significantly wider in the FEM group than in healthy controls (p=.20). Albumin was significantly lower in the FEM group than in the HC group (p<.001). CRP and CAR values were significantly higher in the FEM group than in HC (p=.009 and p=.011, respectively). In the FEM group, HDL value was significantly lower than HC, while LDL value was significantly higher than HC (p=<.001 and p=.001, accordingly). MHR and AIP values were significantly greater in the FEM group than in HC (p=<.001 and p=.006, respectively). The fQRS-T angle in FEM patients was associated with MHR (r=.37). Conclusion: This study is unique in evaluating inflammatory markers, fQRS-T angle, and heart rate in FEM patients. In this study, we found significantly higher inflammatory markers of MHR, CRP, and CAR in FEM patients in the control group. We found that these findings were consistent with the literature. Since the fQRS-T angle was wider in the FEM group, the cardiovascular risk may be increased in the early stages of BD disease.
目的:本研究检测了首发躁狂症患者的炎症标志物和心电图数据。目的是研究疾病早期的炎症过程和双相情感障碍(BD)的额叶QRS-T (fQRS-T)角。材料与方法:经排除标准后，53例FEM患者和59例健康对照(HC)纳入研究。评估参与者的社会人口学、心电图(ECG)和实验室数据。结果:两组患者平均年龄和性别分布差异无统计学意义(p=。743, p =。294年,分别)。FEM组心率明显高于HC组(p< 0.001)。FEM组的fQRS-T明显宽于健康对照组(p= 0.20)。FEM组白蛋白明显低于HC组(p< 0.001)。CRP和CAR值在FEM组明显高于HC组(p=。009和p=。011年,分别)。FEM组HDL值显著低于HC组，LDL值显著高于HC组(p=<。001和p=。001年,相应的)。FEM组的MHR和AIP值显著高于HC组(p=<。001和p=。006年,分别)。FEM患者fQRS-T角度与MHR相关(r= 0.37)。结论:本研究在评估FEM患者的炎症标志物、fQRS-T角和心率方面具有独特的意义。在本研究中，我们发现对照组FEM患者的MHR、CRP和CAR炎症标志物明显升高。我们发现这些发现与文献一致。由于FEM组的fQRS-T角度更宽，在BD疾病的早期可能会增加心血管风险。
{"title":"Investigation of Electrocardiogram and Inflammation Parameters in Patients with First Episode Mania","authors":"Yasar c, Sabri Abu, S. Ayhan, Bulut c, A. Tekin","doi":"10.5455/annalsmedres.2022.12.377","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.377","url":null,"abstract":"Aim: This study examined inflammation markers and electrocardiogram data in patients with first-episode mania (FEM). It aimed to examine the inflammation processes in the early stages of the disease and the frontal QRS-T (fQRS-T) angle in bipolar disorder (BD). Materials and Methods: After exclusion criteria, 53 FEM patients and 59 healthy controls (HC) were included in the study. Sociodemographic, electrocardiogram (ECG) and lab data of the participants were evaluated. Results: Mean of age and gender distribution did not differ between the groups (p=.743, p=.294, respectively). The heart rate of the FEM group was significantly higher than the HC group (p<.001). fQRS-T was significantly wider in the FEM group than in healthy controls (p=.20). Albumin was significantly lower in the FEM group than in the HC group (p<.001). CRP and CAR values were significantly higher in the FEM group than in HC (p=.009 and p=.011, respectively). In the FEM group, HDL value was significantly lower than HC, while LDL value was significantly higher than HC (p=<.001 and p=.001, accordingly). MHR and AIP values were significantly greater in the FEM group than in HC (p=<.001 and p=.006, respectively). The fQRS-T angle in FEM patients was associated with MHR (r=.37). Conclusion: This study is unique in evaluating inflammatory markers, fQRS-T angle, and heart rate in FEM patients. In this study, we found significantly higher inflammatory markers of MHR, CRP, and CAR in FEM patients in the control group. We found that these findings were consistent with the literature. Since the fQRS-T angle was wider in the FEM group, the cardiovascular risk may be increased in the early stages of BD disease.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74425735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Elderly populations often have insufficient vitamin D (vit-D), which may contribute to autoimmune diseases and inflammation. Few studies have examined vit-D levels and immune function in humans. The study looked at vit-D levels and inflammatory markers in older adults. Material and Methods: Retrospective research was done. The hospital's records were searched for the study's data. Participants were 65-year-olds who applied to the internal medicine outpatient clinic between May 2020 and May 2022. Each person's vit-D, CRP, Lymphocyte/Monocyte, Neutrophil/Lymphocyte, Platelet/Lymphocyte, Ferritin, and Prognostic nutritional index (PNI) levels were measured. Results: The information from 2118 patients was analyzed as part of the study. Of those patients, 324 met the requirements for participation in the research, and the participants' average age was 73.21 years, with a standard deviation of 5.24 years. The average level of vit-D found in people was 14.18 nmol/L, with a standard deviation of 6.14 nmol/L. It was discovered that there was a negative correlation that was statistically significant between the individuals' levels of vit-D and the ratio of CRP to MPV (p less than 0.05). Vit-D and PNI were found to have a correlation of r=0.205, which was found to be positive and significant (p <0.05). Every 0.721-unit increase in PNI will result in an additional 1 unit of 25(OH) vit-D. It was found that the CRP (mg/L) variable contributed significantly to the model, and it was discovered that the presence of 1 unit of 25(OH) vit-D was increased for every 0.202 unit decrease (p <0.05). Conclusion: Insufficient vitamin 25(OH)D is found in the elderly population. 25(OH) vit-D has a negative relationship with CRP (mg/L) and MPV (fL), but a positive relationship with PNI, an indicator of nutritional status. The study suggests that if an elderly person is disabled, nutritional supplements should be provided.
{"title":"The correlation between vitamin D levels and inflammation, as well as the Prognostic Nutritional Index (PNI), in people who are over the age of 60.","authors":"Nurgül Arslan, B. Yaprak","doi":"10.5455/annalsmedres.2022.12.396","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.396","url":null,"abstract":"Aim: Elderly populations often have insufficient vitamin D (vit-D), which may contribute to autoimmune diseases and inflammation. Few studies have examined vit-D levels and immune function in humans. The study looked at vit-D levels and inflammatory markers in older adults. Material and Methods: Retrospective research was done. The hospital's records were searched for the study's data. Participants were 65-year-olds who applied to the internal medicine outpatient clinic between May 2020 and May 2022. Each person's vit-D, CRP, Lymphocyte/Monocyte, Neutrophil/Lymphocyte, Platelet/Lymphocyte, Ferritin, and Prognostic nutritional index (PNI) levels were measured. Results: The information from 2118 patients was analyzed as part of the study. Of those patients, 324 met the requirements for participation in the research, and the participants' average age was 73.21 years, with a standard deviation of 5.24 years. The average level of vit-D found in people was 14.18 nmol/L, with a standard deviation of 6.14 nmol/L. It was discovered that there was a negative correlation that was statistically significant between the individuals' levels of vit-D and the ratio of CRP to MPV (p less than 0.05). Vit-D and PNI were found to have a correlation of r=0.205, which was found to be positive and significant (p <0.05). Every 0.721-unit increase in PNI will result in an additional 1 unit of 25(OH) vit-D. It was found that the CRP (mg/L) variable contributed significantly to the model, and it was discovered that the presence of 1 unit of 25(OH) vit-D was increased for every 0.202 unit decrease (p <0.05). Conclusion: Insufficient vitamin 25(OH)D is found in the elderly population. 25(OH) vit-D has a negative relationship with CRP (mg/L) and MPV (fL), but a positive relationship with PNI, an indicator of nutritional status. The study suggests that if an elderly person is disabled, nutritional supplements should be provided.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"2005 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72617783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of the Serum Albumin Levels at the Time of Admission on the Duration of Hospitalization in Indirect Hyperbilirubinemia","authors":"Seda Aydoğan, N. Fettah, H. Akduman, C. Geyik, A. lu","doi":"10.5455/annalsmedres.2022.12.366","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.366","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77644869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of pain during endovenous laser ablation of the great saphenous vein with ultrasound-guided femoral nerve block with local anesthesia","authors":"O. Hanbeyoğlu, S. Aydin","doi":"10.5455/annalsmedres.2022.11.338","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.11.338","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85947421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: High fetal hemoglobin value is one of the quantitative trait in beta thalassemia and may effect transfusion dependency status of beta thalassemic cases. There are population-based differences about known genetic modifiers of different fetal hemoglobin values. We aimed to find if high fetal hemoglobin value are caused by XmnI-HBG2 polymorphism, rs11886868 of BCL11A or KLF1 whole gene mutations. Material and Methods: Genotyping procedure of thirty well re-defined and characterized transfusion dependent beta thalassemia patients was conducted via either sanger sequencing or and PCR-RFLP. Statistic analysis of groups and multiple logistic regression analysis of related genotypes were performed. Results: We found strong correlations between transfusion dependency and fetal hemoglobin levels (P<0.05). IVS.I.110 (G>A) homozygous mutation was found to be predominant in HBB gene. Lower fetal hemoglobin levels were seen in IVS.I.110 (G>A) homozygous group (P<0.05). Total count of variations among the three modifier genes BCL11A polymorphism was leading first. We did not observe any statistically significant relationship in patients with beta thalassemia major patients who have high fetal hemoglobin values between three modifiers group (P>0.05). Conclusion: This is the first research report from Turkey in terms of 3 different modifiers were analysed and evaluated. Since some cases have more than one variations in these three modifiers, involving higher sample size may overcome this challenge. Other genomic alterations rather than XmnI-HBG2, variations of BCL11A rs11886868 and mutation profile of KLF1 gene, which could decrease or abolish the effect of gamma globin repressors, may have more direct role with high fetal hemoglobin levels in patients with transfusion dependent beta thalassemia in Turkey.
{"title":"Fetal Hemoglobin Altering Effects of KLF1, BCL11A rs11886868 and XmnI-HBG2 on Transfusion Dependent Beta Thalassemia Patients: Preeliminary Study","authors":"Y. Arıkan, B. Yolcular, Erdal Lu, I. Keser","doi":"10.5455/annalsmedres.2023.02.059","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.059","url":null,"abstract":"Aim: High fetal hemoglobin value is one of the quantitative trait in beta thalassemia and may effect transfusion dependency status of beta thalassemic cases. There are population-based differences about known genetic modifiers of different fetal hemoglobin values. We aimed to find if high fetal hemoglobin value are caused by XmnI-HBG2 polymorphism, rs11886868 of BCL11A or KLF1 whole gene mutations. Material and Methods: Genotyping procedure of thirty well re-defined and characterized transfusion dependent beta thalassemia patients was conducted via either sanger sequencing or and PCR-RFLP. Statistic analysis of groups and multiple logistic regression analysis of related genotypes were performed. Results: We found strong correlations between transfusion dependency and fetal hemoglobin levels (P<0.05). IVS.I.110 (G>A) homozygous mutation was found to be predominant in HBB gene. Lower fetal hemoglobin levels were seen in IVS.I.110 (G>A) homozygous group (P<0.05). Total count of variations among the three modifier genes BCL11A polymorphism was leading first. We did not observe any statistically significant relationship in patients with beta thalassemia major patients who have high fetal hemoglobin values between three modifiers group (P>0.05). Conclusion: This is the first research report from Turkey in terms of 3 different modifiers were analysed and evaluated. Since some cases have more than one variations in these three modifiers, involving higher sample size may overcome this challenge. Other genomic alterations rather than XmnI-HBG2, variations of BCL11A rs11886868 and mutation profile of KLF1 gene, which could decrease or abolish the effect of gamma globin repressors, may have more direct role with high fetal hemoglobin levels in patients with transfusion dependent beta thalassemia in Turkey.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76777543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of CO-RADS, RT-PCR and Chest CT Score; A report of 519 cases","authors":"Aylin Kus, Y. Okuturlar, C. Kalaycı, Yasemin Gundogdu, ftihar Koksal, E. Kızılkaya","doi":"10.5455/annalsmedres.2022.08.243","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.243","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85780139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To examine the relationship between spousal support and depression, anxiety, stress, and prenatal attachment in high-risk pregnant women. Materials and Methods: Data were collected from 375 high-risk pregnant women in their 2nd/3rd trimesters in November 2021-February 2022. An introductory information form, the Spouse Support Scale (SSS), the Depression, Anxiety, and Stress Scale (DASS-21), and the Prenatal Attachment Inventory (PAI) were used to collect data. Results: Median SSS score was 76 (29-81), median PAI score was 74 (31-84). Median anxiety scale score was 4 (0-21), depression scale score was 2 (0-21), and stress scales score was 3 (0-21). There was a positive significant relationship between spousal support and prenatal attachment, and a negative significant relationship between spousal support and anxiety, depression, and stress (p<0.001). Conclusion: Inadequate spousal support in high-risk pregnancies is a risk factor for prenatal attachment, anxiety, depression, and stress levels. Keywords: High risk pregnancy; Spousal support; Anxiety; Depression.
{"title":"The relationship between spousal support and depression, anxiety, stress, and prenatal attachment in high-risk pregnancies","authors":"A. M. Res, B. Çallı, H. Dikmen","doi":"10.5455/annalsmedres.2023.03.070","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.03.070","url":null,"abstract":"Objective: To examine the relationship between spousal support and depression, anxiety, stress, and prenatal attachment in high-risk pregnant women. Materials and Methods: Data were collected from 375 high-risk pregnant women in their 2nd/3rd trimesters in November 2021-February 2022. An introductory information form, the Spouse Support Scale (SSS), the Depression, Anxiety, and Stress Scale (DASS-21), and the Prenatal Attachment Inventory (PAI) were used to collect data. Results: Median SSS score was 76 (29-81), median PAI score was 74 (31-84). Median anxiety scale score was 4 (0-21), depression scale score was 2 (0-21), and stress scales score was 3 (0-21). There was a positive significant relationship between spousal support and prenatal attachment, and a negative significant relationship between spousal support and anxiety, depression, and stress (p<0.001). Conclusion: Inadequate spousal support in high-risk pregnancies is a risk factor for prenatal attachment, anxiety, depression, and stress levels. Keywords: High risk pregnancy; Spousal support; Anxiety; Depression.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73148046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To determine the effects of small kidney and consanguineous marriage in chronic kidney disease (CKD). Materials and Methods: Patients with a vertical kidney size of 100 mm or less, who applied to the outpatient clinic between September 2021 and 2022, were included in the study. Urinary ultrasonography and renal function tests were recorded one year apart. Two groups, with and without relatives, were compared. SPSS 22.0 program was used for statistics. p< .05 was considered significant. Results: The parents of 50 of the 94 cases with small kidney included in the study were related and 44 of them were not related. 57.4% were female, mean age was 49.86. Urea, creatinine, e-GFR, hemoglobin, albumin, phosphorus, calcium, PTH, ferritin, and urinary USG used in chronic kidney disease progression follow-up were compared between the groups with and without parental consanguinity. Conclusion: Early application of prevention measures with ultrasound detection of small kidney related to consanguineous marriage at an earlier age before kidney dysfunction is established will slow down the progression.
{"title":"The Effects of Consanguineous Marriage on Small Kidney in Chronic Kidney Disease\u0000Small Kidneys in Chronic Kidney Disease","authors":"Semahat rali","doi":"10.5455/annalsmedres.2022.12.368","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.368","url":null,"abstract":"Aim: To determine the effects of small kidney and consanguineous marriage in chronic kidney disease (CKD). Materials and Methods: Patients with a vertical kidney size of 100 mm or less, who applied to the outpatient clinic between September 2021 and 2022, were included in the study. Urinary ultrasonography and renal function tests were recorded one year apart. Two groups, with and without relatives, were compared. SPSS 22.0 program was used for statistics. p< .05 was considered significant. Results: The parents of 50 of the 94 cases with small kidney included in the study were related and 44 of them were not related. 57.4% were female, mean age was 49.86. Urea, creatinine, e-GFR, hemoglobin, albumin, phosphorus, calcium, PTH, ferritin, and urinary USG used in chronic kidney disease progression follow-up were compared between the groups with and without parental consanguinity. Conclusion: Early application of prevention measures with ultrasound detection of small kidney related to consanguineous marriage at an earlier age before kidney dysfunction is established will slow down the progression.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80375548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. Eight of our patients reported having contact with someone who had COVID-19 infection or was suspected of having the infection, and in three of these cases (37.5%) the patient reported having at least one symptom of infection. Out of the 18 patients who were tested, 4 (22.2%) had a positive result. Positive test results were associated with more symptoms in patients (3.8 vs 0.3, p0.001) than negative test results. In Gaucher patients, symptoms or positive test results were not correlated with age, gender, BMI, comorbidity, genotype, previous splenectomy, or enzyme replacement therapy. All of our patients only received supportive care; none of them required intensive care or specialized treatment. Our research revealed that there was a low risk of serious side effects in other chronic patients following SARS-CoV-2 infection in Gaucher patients. In this regard, studies with larger case series are required.
慢性疾病患者感染SARS-CoV-2的发病率和死亡率较高。戈谢病是一种罕见的溶酶体贮积病。慢性髓细胞免疫激活是由酸性-葡萄糖苷酶活性下降和炎症鞘糖脂积累引起的。目前尚不清楚SARS-CoV-2如何影响戈谢病等罕见疾病人群。髓细胞免疫激活在戈谢病可能倾向于严重影响这种感染。到目前为止，在土耳其进行的唯一研究是这个。慢性疾病患者感染SARS-CoV-2的发病率和死亡率较高。戈谢病是一种罕见的溶酶体贮积病。慢性髓细胞免疫激活是由酸性-葡萄糖苷酶活性下降和炎症鞘糖脂积累引起的。目前尚不清楚SARS-CoV-2如何影响戈谢病等罕见疾病人群。髓细胞免疫激活在戈谢病可能倾向于严重影响这种感染。到目前为止，在土耳其进行的唯一研究是这个。我们的8名患者报告与COVID-19感染者或疑似感染者有过接触，其中3例(37.5%)患者报告至少有一种感染症状。在接受检查的18名患者中，4名(22.2%)呈阳性。与阴性检测结果相比，阳性检测结果与更多患者症状相关(3.8 vs 0.3, p0.001)。戈谢病患者的症状或阳性检测结果与年龄、性别、BMI、合并症、基因型、既往脾切除术或酶替代治疗无关。我们所有的病人都只接受支持性治疗;他们都不需要重症监护或专门治疗。我们的研究表明，戈歇患者感染SARS-CoV-2后，其他慢性患者发生严重副作用的风险较低。在这方面，需要更大规模的案例研究。
{"title":"Viral respiratory tract infection in Gaucher disease, a rare disease: A case study of 24 patients in Malatya-Turkey","authors":"A. M. Res, B. Yaprak, H. Aladag, M. Aladağ","doi":"10.5455/annalsmedres.2022.12.382","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.382","url":null,"abstract":"People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. Eight of our patients reported having contact with someone who had COVID-19 infection or was suspected of having the infection, and in three of these cases (37.5%) the patient reported having at least one symptom of infection. Out of the 18 patients who were tested, 4 (22.2%) had a positive result. Positive test results were associated with more symptoms in patients (3.8 vs 0.3, p0.001) than negative test results. In Gaucher patients, symptoms or positive test results were not correlated with age, gender, BMI, comorbidity, genotype, previous splenectomy, or enzyme replacement therapy. All of our patients only received supportive care; none of them required intensive care or specialized treatment. Our research revealed that there was a low risk of serious side effects in other chronic patients following SARS-CoV-2 infection in Gaucher patients. In this regard, studies with larger case series are required.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87729431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: It was aimed to investigate the effectiveness of nutritional counseling services provided in the diabetes and obesity unit of primary health care services for the control of obesity. Materials and Methods: This study is a retrospectively descriptive research. People applied to the diabetes and obesity unit of a District Health Directorate in Istanbul between 01.01.2017-01.04.2022 constitute the population. Analysis about the first application (height, weight, sociodemographics) was made with 3259 people; weight loss was evaluated within 1282 people. Mean, standard deviation, median, minimum, maximum values, numbers (n) and percentages (%) were used for descriptive data. The Mann Whitney U was used if the data not normally distributed. Chi-square test was used for categorical variables. Multivariate analysis is made with Cox-regression analysis. Statistical significance level was p<0.05. Results: 2973 (91.2%) of the participants were women. The median age was 38.0 (15.0-83.0). Height, weight and BMI median values were 158.0 cm (116.0-190.0), 83.6 kg (56.0-160.2), 33.0 kg/m2 (25.0-64.7), respectively. Weight and BMI loss was observed in 90.8% of the patients. The median weight and BMI loss loss were 2.7 kg (-21.40-56.10) and 1.1 kg/m2 (-8.79-22.69). According to univariate analysis, weight loss percentage of 5% and above was significantly higher in those with low educational status, but this significance was not observed in multivariate analysis. Conclusion: Weight loss was achieved 90.8% of the participants. While it is encouraging to benefit from nutritional counseling at a high percentage; it is important to understand the barriers to weight loss for participants who cannot benefit.
{"title":"Evaluation of nutritional counseling service provided within primary health care at a district level","authors":"M. Sezerol, Zeynep Alta","doi":"10.5455/annalsmedres.2023.01.037","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.037","url":null,"abstract":"Objective: It was aimed to investigate the effectiveness of nutritional counseling services provided in the diabetes and obesity unit of primary health care services for the control of obesity. Materials and Methods: This study is a retrospectively descriptive research. People applied to the diabetes and obesity unit of a District Health Directorate in Istanbul between 01.01.2017-01.04.2022 constitute the population. Analysis about the first application (height, weight, sociodemographics) was made with 3259 people; weight loss was evaluated within 1282 people. Mean, standard deviation, median, minimum, maximum values, numbers (n) and percentages (%) were used for descriptive data. The Mann Whitney U was used if the data not normally distributed. Chi-square test was used for categorical variables. Multivariate analysis is made with Cox-regression analysis. Statistical significance level was p<0.05. Results: 2973 (91.2%) of the participants were women. The median age was 38.0 (15.0-83.0). Height, weight and BMI median values were 158.0 cm (116.0-190.0), 83.6 kg (56.0-160.2), 33.0 kg/m2 (25.0-64.7), respectively. Weight and BMI loss was observed in 90.8% of the patients. The median weight and BMI loss loss were 2.7 kg (-21.40-56.10) and 1.1 kg/m2 (-8.79-22.69). According to univariate analysis, weight loss percentage of 5% and above was significantly higher in those with low educational status, but this significance was not observed in multivariate analysis. Conclusion: Weight loss was achieved 90.8% of the participants. While it is encouraging to benefit from nutritional counseling at a high percentage; it is important to understand the barriers to weight loss for participants who cannot benefit.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88079805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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