Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.05.108
Bet man, M-W Rul, Bet ek, A. Lu, M. z
Objective: Parkinson’s disease (PD) is a progressive, neurodegenerative disease associated with the loss of dopaminergic neurons. Multiple possible mechanisms such as oxidative stress, mitochondrial dysfunction or excitotoxicity caused by glutamate are thought to mediate neuronal loss in PD. It is stated that transcranial direct current stimulation (tDCS) has positive effects on PD, but underlying mechanisms are still largely undefined. So, in this study, the effects of tDCS on PD and the relationship of these effects with glutamate and NMDA levels were investigated. Materials and Methods: To induce the PD model, 6-OHDA (200 µM) was administered to SH-SY5Y cells for 24 hours. Electrical stimulation was applied to the SH-SY5Y cells at 20 minutes and 7 hours after 24 hours. The effect of tDCS on cell viability was investigated by MTT 3-(4, 5-Dimethylthiazol-2-yl) method. Glutamate and NMDA receptor levels were measured using commercial kit. Results: It has been observed that 6-OHDA increases cell death in SH-SY5Y cells, while electrical stimulation reverses this effect. While 6-OHDA increased the glutamate level, tDCS therapy reversed this effect. No significant difference was found between the groups in NMDA levels. Conclusion: Our findings suggest that tDCS can be a functional therapy on PD by reducing glutamate toxicity.
{"title":"Investigation of the Effects of Direct Current Stimulation on Parkinson Disease in vitro","authors":"Bet man, M-W Rul, Bet ek, A. Lu, M. z","doi":"10.5455/annalsmedres.2023.05.108","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.108","url":null,"abstract":"Objective: Parkinson’s disease (PD) is a progressive, neurodegenerative disease associated with the loss of dopaminergic neurons. Multiple possible mechanisms such as oxidative stress, mitochondrial dysfunction or excitotoxicity caused by glutamate are thought to mediate neuronal loss in PD. It is stated that transcranial direct current stimulation (tDCS) has positive effects on PD, but underlying mechanisms are still largely undefined. So, in this study, the effects of tDCS on PD and the relationship of these effects with glutamate and NMDA levels were investigated. Materials and Methods: To induce the PD model, 6-OHDA (200 µM) was administered to SH-SY5Y cells for 24 hours. Electrical stimulation was applied to the SH-SY5Y cells at 20 minutes and 7 hours after 24 hours. The effect of tDCS on cell viability was investigated by MTT 3-(4, 5-Dimethylthiazol-2-yl) method. Glutamate and NMDA receptor levels were measured using commercial kit. Results: It has been observed that 6-OHDA increases cell death in SH-SY5Y cells, while electrical stimulation reverses this effect. While 6-OHDA increased the glutamate level, tDCS therapy reversed this effect. No significant difference was found between the groups in NMDA levels. Conclusion: Our findings suggest that tDCS can be a functional therapy on PD by reducing glutamate toxicity.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"55 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80695516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.02.041
B. Harma, F. Tecellioglu
Objective The aim of this study was to investigate whether there were differences in the Paneth cells between children with acute appendicitis (AA) and those with normal appendix (NA), and to reveal the distribution of and morphological changes in Paneth cells in appendix inflammation. Materials and Methods The data of 63 patients who underwent appendectomy diagnosed with acute appendicitis between January 2021 and December 2022, including age, gender, operative diagnosis, and postoperative histopathological examination results, were analyzed retrospectively. To evaluate the distribution and changes of Paneth cells throughout AA and NA groups, samples with hematoxylin and eosin (H & E)-stained sections were obtained from the Department of Histopathology's archives. Selected blocks were stained with Masson-Trichrome. The number of Paneth cells and the degree of granular density in the appendicitis tissues were statistically evaluated and compared with the results of the control group. Results A total of 63 appendectomies were performed, including 31 incidental appendectomies and 32 performed for preoperative diagnosis of acute appendicitis. There were no statistically significant differences between the groups that underwent surgery for AA and the NA in terms of gender and age (p>0.05). It was observed that the number of Paneth cells and granule density decreased significantly in acute appendicitis (AA) group (p<0.05). Conclusion Reduction or developmental deficiency in Paneth cells, which results in the loss of protective secretion, may increase the appendix's susceptibility to bacterial infection by allowing organisms to adhere and move across the mucosa. Such enhancement of infection may contribute to the pathogenesis of appendicitis.
{"title":"A DEFICIENCY OR DEVELOPMENTAL DEFECT IN PANETH CELLS MAY LEAD TO ACUTE APPENDICITIS IN CHILDREN","authors":"B. Harma, F. Tecellioglu","doi":"10.5455/annalsmedres.2023.02.041","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.041","url":null,"abstract":"Objective The aim of this study was to investigate whether there were differences in the Paneth cells between children with acute appendicitis (AA) and those with normal appendix (NA), and to reveal the distribution of and morphological changes in Paneth cells in appendix inflammation. Materials and Methods The data of 63 patients who underwent appendectomy diagnosed with acute appendicitis between January 2021 and December 2022, including age, gender, operative diagnosis, and postoperative histopathological examination results, were analyzed retrospectively. To evaluate the distribution and changes of Paneth cells throughout AA and NA groups, samples with hematoxylin and eosin (H & E)-stained sections were obtained from the Department of Histopathology's archives. Selected blocks were stained with Masson-Trichrome. The number of Paneth cells and the degree of granular density in the appendicitis tissues were statistically evaluated and compared with the results of the control group. Results A total of 63 appendectomies were performed, including 31 incidental appendectomies and 32 performed for preoperative diagnosis of acute appendicitis. There were no statistically significant differences between the groups that underwent surgery for AA and the NA in terms of gender and age (p>0.05). It was observed that the number of Paneth cells and granule density decreased significantly in acute appendicitis (AA) group (p<0.05). Conclusion Reduction or developmental deficiency in Paneth cells, which results in the loss of protective secretion, may increase the appendix's susceptibility to bacterial infection by allowing organisms to adhere and move across the mucosa. Such enhancement of infection may contribute to the pathogenesis of appendicitis.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"306 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77778378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.11.339
Yasemin nsal, zen l, S. Cander, Co Ate, E. Aydemir, Oktay nsal, C. Ersoy, Erdin rk
We examined the patients with hyperinsulinemic hypoglycemia who were performed non-invasive imaging techniques with doubtful or failed results. We compared the performances of the Selective Arterial Calcium Stimulation Test (SACST) and non-invasive imaging techniques. Eight patients with hyperinsulinemic hypoglycemia, performed SACST after evaluating with imaging modalities were examined retrospectively. Three patients were diagnosed with Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS), 4 with insulinoma, and 1 with autoimmune hypoglycemia after SACST. While the concordance between the SACST and surgery-proven pathology for insulinoma was 50% (2/4), the accuracy in the localization of insulinoma was 25%. Although SACST does not have high concordance with surgery-proven pathology and accuracy in the localization of insulinoma, it may be preferred in the differential diagnosis of hyperinsulinemic hypoglycemia in medical centers where other imaging techniques are not available, or in cases where other imaging methods obtain suspicious/inadequate diagnosis.
{"title":"The use of selective arterial calcium stimulation test in the diagnosis of the hyperinsulinemic hypoglycemia","authors":"Yasemin nsal, zen l, S. Cander, Co Ate, E. Aydemir, Oktay nsal, C. Ersoy, Erdin rk","doi":"10.5455/annalsmedres.2022.11.339","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.11.339","url":null,"abstract":"We examined the patients with hyperinsulinemic hypoglycemia who were performed non-invasive imaging techniques with doubtful or failed results. We compared the performances of the Selective Arterial Calcium Stimulation Test (SACST) and non-invasive imaging techniques. Eight patients with hyperinsulinemic hypoglycemia, performed SACST after evaluating with imaging modalities were examined retrospectively. Three patients were diagnosed with Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS), 4 with insulinoma, and 1 with autoimmune hypoglycemia after SACST. While the concordance between the SACST and surgery-proven pathology for insulinoma was 50% (2/4), the accuracy in the localization of insulinoma was 25%. Although SACST does not have high concordance with surgery-proven pathology and accuracy in the localization of insulinoma, it may be preferred in the differential diagnosis of hyperinsulinemic hypoglycemia in medical centers where other imaging techniques are not available, or in cases where other imaging methods obtain suspicious/inadequate diagnosis.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82238551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.247
mit N, mer Ayik
ABSTRACT Purpose: In this study, the functional results of patients with femoral intertrochanteric fractures who underwent surgery were compared with their clinical features in terms of proximal femoral nail ( PFN ) and bipolar hemiarthroplasty ( BPH ). Methods: PFN (Group 1) was implanted in 40 of 89 patients (44 female, 45 male) aged between 51-80 (mean 68,16 ± 6,78) whereas BPH (Group 2) was used with 49 patients. Age, gender, fracture mechanism, additional disease, Body mass index (BMI), Albumin level, Hemoglobin (Hb) decrease level, T-score, American Society of Anesthesiologists (ASA) classification, type of anesthesia, surgery type, operation time, hospital stay and full weight-bearing time, the scores of Harris Hip Function (HHS), the social function of Jensen (JSF), Parker-Palmer mobility (PPMS) in preoperative and postoperative periods, and postoperative complications were all recorded. Results: In group 1; patients were younger, operation time was 46.78 ± 5.29 minutes and hospital stay was 2.48±0.75 days, which were shorter compared with group 2. For group 1, most surgery types were closed, T-score was -2.49±0.59 and better, the time of full weight-bearing was 3.48±0.78 months, Hb decrease was 1.17±0.37 and less, and Albumin level was 3.11±0.4 g/dL and higher compared to group 2 (p<0.05). HHS was better in the BPH group at the sixth month (p<0.05). In group 1, the 12th, and 24th months scores of JSF were better, PPMS was higher in all evaluations (p<0.05). Operation time, ASA, T-score, albumin correlate with functional scores, while BMI and Hb did not. Conclusion: Many factors are important for progressing patients with intertrochanteric femur fractures toward a functional level. Considering these parameters in patients with femoral intertrochanteric fracture , PFN or BPH can both be used for treatment according to the surgeon's preference.
{"title":"Functional results of patients with femoral intertrochanteric fractures who underwent surgery of proximal femoral nail or bipolar hemiarthroplasty – a comparative study","authors":"mit N, mer Ayik","doi":"10.5455/annalsmedres.2022.08.247","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.247","url":null,"abstract":"ABSTRACT Purpose: In this study, the functional results of patients with femoral intertrochanteric fractures who underwent surgery were compared with their clinical features in terms of proximal femoral nail ( PFN ) and bipolar hemiarthroplasty ( BPH ). Methods: PFN (Group 1) was implanted in 40 of 89 patients (44 female, 45 male) aged between 51-80 (mean 68,16 ± 6,78) whereas BPH (Group 2) was used with 49 patients. Age, gender, fracture mechanism, additional disease, Body mass index (BMI), Albumin level, Hemoglobin (Hb) decrease level, T-score, American Society of Anesthesiologists (ASA) classification, type of anesthesia, surgery type, operation time, hospital stay and full weight-bearing time, the scores of Harris Hip Function (HHS), the social function of Jensen (JSF), Parker-Palmer mobility (PPMS) in preoperative and postoperative periods, and postoperative complications were all recorded. Results: In group 1; patients were younger, operation time was 46.78 ± 5.29 minutes and hospital stay was 2.48±0.75 days, which were shorter compared with group 2. For group 1, most surgery types were closed, T-score was -2.49±0.59 and better, the time of full weight-bearing was 3.48±0.78 months, Hb decrease was 1.17±0.37 and less, and Albumin level was 3.11±0.4 g/dL and higher compared to group 2 (p<0.05). HHS was better in the BPH group at the sixth month (p<0.05). In group 1, the 12th, and 24th months scores of JSF were better, PPMS was higher in all evaluations (p<0.05). Operation time, ASA, T-score, albumin correlate with functional scores, while BMI and Hb did not. Conclusion: Many factors are important for progressing patients with intertrochanteric femur fractures toward a functional level. Considering these parameters in patients with femoral intertrochanteric fracture , PFN or BPH can both be used for treatment according to the surgeon's preference.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81437820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.10.310
S. Karakas
Introduction: Emergent operation is the accepted standart therapy of acute appendicitis. But conservative medical therapy is an emerging solution for acute appendicitis. We aimed to publish the conservative treatment experience of Inonu University Medical School, Department of General Surgery. Material and Method: Between January 2020 and January 2022, patients who had a clinical suspicous acute appendicitis with an Abdominal Ultrasonography or a computer tomography reporting a term ’appendicitis’ that referred to Emergency or General Surgery Department and also had a medical therapy with a non-operative approach were detected in the hospital data system. Patient demographics and clinical data analysed retrospectively. Results: Fifteen patients were detected within the 2 years period that had been received medical therapy for acute appendicitis. Median age was 32.0 (min:19 - max:70), median appendix diameter was 7.2 mm (min:5.5 - max:11.0). One patient was died due to Non-Hodgkin Lymphoma after 16 days of diagnosis of acute appendicitis. None of the patients required an operation during surveillance. Most frequent reasons for conservative treatment were not eliminating the diagnosis of pelvic inflammatory disease, inflammatory intestinal disease and urinary tract infections. Discussion and Conclusion: While some comorbidities can go along with acute appendicitis such as cardiac and systemic haematologic diseases, some of them mimic acute appendicitis such as pelvic inflamatory disease or inflamatory bowel diseases. Especially elder patients, who have a suspicous case, with a low CRP and Neutrophilia counts with an uncomplicated appendicitis, may benefit from antibiotherapy. More patients, that had an appendectomy history need to be evaluated on this aspect.
{"title":"CONSERVATIVE TREATMENT AND FOLLOW-UP FOR ACUTE APPANDICITIS: IS EMERGENT SURGERY NECESSARY ?","authors":"S. Karakas","doi":"10.5455/annalsmedres.2022.10.310","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.310","url":null,"abstract":"Introduction: Emergent operation is the accepted standart therapy of acute appendicitis. But conservative medical therapy is an emerging solution for acute appendicitis. We aimed to publish the conservative treatment experience of Inonu University Medical School, Department of General Surgery. Material and Method: Between January 2020 and January 2022, patients who had a clinical suspicous acute appendicitis with an Abdominal Ultrasonography or a computer tomography reporting a term ’appendicitis’ that referred to Emergency or General Surgery Department and also had a medical therapy with a non-operative approach were detected in the hospital data system. Patient demographics and clinical data analysed retrospectively. Results: Fifteen patients were detected within the 2 years period that had been received medical therapy for acute appendicitis. Median age was 32.0 (min:19 - max:70), median appendix diameter was 7.2 mm (min:5.5 - max:11.0). One patient was died due to Non-Hodgkin Lymphoma after 16 days of diagnosis of acute appendicitis. None of the patients required an operation during surveillance. Most frequent reasons for conservative treatment were not eliminating the diagnosis of pelvic inflammatory disease, inflammatory intestinal disease and urinary tract infections. Discussion and Conclusion: While some comorbidities can go along with acute appendicitis such as cardiac and systemic haematologic diseases, some of them mimic acute appendicitis such as pelvic inflamatory disease or inflamatory bowel diseases. Especially elder patients, who have a suspicous case, with a low CRP and Neutrophilia counts with an uncomplicated appendicitis, may benefit from antibiotherapy. More patients, that had an appendectomy history need to be evaluated on this aspect.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90450382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.12.379
Kemal Din, zlem Deveci
Aim: Cesarean section rates have increased, and although various measures such as antenatal education programs have been introduced to correct this, these could not be performed face-to-face due to the COVID-19 pandemic, and were largely carried out online. This study was planned to determine the effect on the rate of cesarean deliveries and pregnancy outcomes of classic education received in the antenatal period and its online replacement in such and similar extraordinary situations. Material and Method: The research was designed as a retrospective, cohort study. Fifty women undergoing childbirth in our hospital and who received online antenatal education (Group 1), 101 women who received classic education (Group 2), and 77 women receiving no education (Group 3) took part in the study. Patient data were retrieved from the hospital information system and patient records. Results: This study involved 228 pregnant women. Fifty pregnant women (22%) receiving antenatal online education were assigned to Group 1, 101 women (44%) receiving classic face-to-face education to Group 2, and 77 women (34%) receiving no education to Group 3. Forty percent of Group 1, given online education, and 62.4% of Group 2, given classic education, were able to give birth via the normal vaginal route, and the difference was statistically significant (0.001). Cesarean delivery rates were significantly higher in Group 1 (60%) than in Group 2 (37.6%) (0.001). Statistically similar results were determined in all three groups in terms of birth weight, birth length, and low birth weight. No significant difference was also observed between the three groups in terms of premature birth (<37 weeks) (p=0.67). Conclusion: Online antenatal education does not reduce cesarean delivery rates compared to classic education. However, neonatal outcomes are similar.
{"title":"Can prenatal online education improve pregnancy outcomes compared to classic education?","authors":"Kemal Din, zlem Deveci","doi":"10.5455/annalsmedres.2022.12.379","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.379","url":null,"abstract":"Aim: Cesarean section rates have increased, and although various measures such as antenatal education programs have been introduced to correct this, these could not be performed face-to-face due to the COVID-19 pandemic, and were largely carried out online. This study was planned to determine the effect on the rate of cesarean deliveries and pregnancy outcomes of classic education received in the antenatal period and its online replacement in such and similar extraordinary situations. Material and Method: The research was designed as a retrospective, cohort study. Fifty women undergoing childbirth in our hospital and who received online antenatal education (Group 1), 101 women who received classic education (Group 2), and 77 women receiving no education (Group 3) took part in the study. Patient data were retrieved from the hospital information system and patient records. Results: This study involved 228 pregnant women. Fifty pregnant women (22%) receiving antenatal online education were assigned to Group 1, 101 women (44%) receiving classic face-to-face education to Group 2, and 77 women (34%) receiving no education to Group 3. Forty percent of Group 1, given online education, and 62.4% of Group 2, given classic education, were able to give birth via the normal vaginal route, and the difference was statistically significant (0.001). Cesarean delivery rates were significantly higher in Group 1 (60%) than in Group 2 (37.6%) (0.001). Statistically similar results were determined in all three groups in terms of birth weight, birth length, and low birth weight. No significant difference was also observed between the three groups in terms of premature birth (<37 weeks) (p=0.67). Conclusion: Online antenatal education does not reduce cesarean delivery rates compared to classic education. However, neonatal outcomes are similar.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90517562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.234
Oya Akkaya, Nurser Mutlu, R. Koylu, N. Akilli, O. Koylu, Mehmet Eryilmaz
Aim: The aim of this study was to investigate the associations between the serum levels of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, IL-6/IL-10 ratio and Glasgow Coma Scale (GCS), Acute Physiology and Chronic Health Evaluation (APACHE-II), Sequential Organ Failure Assessment (SOFA) scores and mortality in patients with sepsis. Materials and Methods: The sample of the study consisted of 50 patients (median age: 75 years) presented to the Intensive Care Unit of the Emergency Department between January 2019 and December 2019 with sepsis. Blood samples were taken from all patients on day 1 and day 3. The IL-6, IL-10, TNF-α levels, APACHE-II, SOFA, and GCS scores were recorded on a data collection form. Results: The deceased and the survived groups significantly differed in day-1 (p = 0.013) and day-3 IL-6 (p = 0.016) levels, day-1 IL-6/IL-10 ratio (p = 0.029) and gender. On the other hand, there was no significant difference between the groups in day-1 and day-3 IL-10 levels and day-3 IL-6/IL-10 ratio. The GCS score was significantly lower in the deceased group than in the survived group (p < 0.05). Conclusion: High IL-6 levels and high IL-6/IL-10 ratios on the day of diagnosis with sepsis were found to be correlated with mortality. IL-6 level may be particularly useful for predicting mortality if used in combination with scoring systems such as the GCS and different clinical parameters.
{"title":"Assessment of the Correlations between Interleukin-6 and 10 Levels and Mortality in Patients with Sepsis","authors":"Oya Akkaya, Nurser Mutlu, R. Koylu, N. Akilli, O. Koylu, Mehmet Eryilmaz","doi":"10.5455/annalsmedres.2022.08.234","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.234","url":null,"abstract":"Aim: The aim of this study was to investigate the associations between the serum levels of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, IL-6/IL-10 ratio and Glasgow Coma Scale (GCS), Acute Physiology and Chronic Health Evaluation (APACHE-II), Sequential Organ Failure Assessment (SOFA) scores and mortality in patients with sepsis. Materials and Methods: The sample of the study consisted of 50 patients (median age: 75 years) presented to the Intensive Care Unit of the Emergency Department between January 2019 and December 2019 with sepsis. Blood samples were taken from all patients on day 1 and day 3. The IL-6, IL-10, TNF-α levels, APACHE-II, SOFA, and GCS scores were recorded on a data collection form. Results: The deceased and the survived groups significantly differed in day-1 (p = 0.013) and day-3 IL-6 (p = 0.016) levels, day-1 IL-6/IL-10 ratio (p = 0.029) and gender. On the other hand, there was no significant difference between the groups in day-1 and day-3 IL-10 levels and day-3 IL-6/IL-10 ratio. The GCS score was significantly lower in the deceased group than in the survived group (p < 0.05). Conclusion: High IL-6 levels and high IL-6/IL-10 ratios on the day of diagnosis with sepsis were found to be correlated with mortality. IL-6 level may be particularly useful for predicting mortality if used in combination with scoring systems such as the GCS and different clinical parameters.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89836791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.266
Sevgi zcan, Esra nmez
Introduction Acute pulmonary embolism (PE) is one of the leading causes of mortality. Components of complete blood count indicate thrombotic and/or inflammatory status in various clinical conditions. In this study, we aimed to evaluate if hematological parameters could predict in-hospital mortality in patients presenting with PE. Methods Patients hospitalized with a diagnosis of acute PE in our tertiary center between 2016 and 2022 were involved in this retrospective study. Hematologic parameters obtained on admission were analayzed. PESI scores were calculated and comparative statistical and regression analyses were obtained. Results There were 254 patients (37.4% male). Thirty-eight patients (14.9%) were died in-hospital and formed ‘non-survivors’ group. NLr and RDW were found as independent risk factors associated with in-hospital mortality. Our results revealed a strong correlation between hematological parameters and PESI risk score and a cut off value of 5.9 for NLr was associated with 68.4% sensitivity and 68.1% specificity; besides that, cut off value of 14.1 for RDW was associated with 68.4% sensitivity and 62.6% specificity in prediction of in-hospital mortality. Conclusion Our current study showed that hematological parameters, assessed by routine blood count analysis, may serve as a promising and useful marker to foresee in-hospital mortality in patients presenting thru acute PE especially when used additive to validated risk scores.
{"title":"The Predictive Ability of Hematologic Parameters for In-hospital Mortality In Patients Presenting With Pulmonary Embolism","authors":"Sevgi zcan, Esra nmez","doi":"10.5455/annalsmedres.2022.08.266","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.266","url":null,"abstract":"Introduction Acute pulmonary embolism (PE) is one of the leading causes of mortality. Components of complete blood count indicate thrombotic and/or inflammatory status in various clinical conditions. In this study, we aimed to evaluate if hematological parameters could predict in-hospital mortality in patients presenting with PE. Methods Patients hospitalized with a diagnosis of acute PE in our tertiary center between 2016 and 2022 were involved in this retrospective study. Hematologic parameters obtained on admission were analayzed. PESI scores were calculated and comparative statistical and regression analyses were obtained. Results There were 254 patients (37.4% male). Thirty-eight patients (14.9%) were died in-hospital and formed ‘non-survivors’ group. NLr and RDW were found as independent risk factors associated with in-hospital mortality. Our results revealed a strong correlation between hematological parameters and PESI risk score and a cut off value of 5.9 for NLr was associated with 68.4% sensitivity and 68.1% specificity; besides that, cut off value of 14.1 for RDW was associated with 68.4% sensitivity and 62.6% specificity in prediction of in-hospital mortality. Conclusion Our current study showed that hematological parameters, assessed by routine blood count analysis, may serve as a promising and useful marker to foresee in-hospital mortality in patients presenting thru acute PE especially when used additive to validated risk scores.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85858131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.04.103
Melin Gecer, Seval Turna, B. Gul, Zuhal Gucin
Objective: Colon adenocarcinomas are the most common gastrointestinal tract malignancy and constitute one of the leading causes of mortality and morbidity worldwide. STAT3 is a transcription factor activated by many cytokines and growth factors and plays a crucial role in cell survival, proliferation, and differentiation. In this research, we aimed to elucidate the molecular properties of colon tumors. Materials & Methods:A total of 196 patients with metastatic colon tumors whose samples were analyzed for KRAS, NRAS, and BFAF between 2016 and 2022 have been investigated in this retrospective study. The samples were analyzed via polymerase chain reaction(PCR)at our institution. STAT3 has been processed to all cases immunohistochemically, and staining intensities were graded.The results were compared with prognostic factors such as tumor molecular characteristics, lymph node status, grade, location, and diameter. Results: A total of 196 patients, 79 (40.3%) female and 117 (59.7%) male, were included in the evaluation within the scope of the study. There was no significant difference between STAT3 staining intensities in terms of demographic characteristics. On the contrary, there was a statistically significant relationship regarding tumor grades (p<0.05). KRAS mutation was found in 40.8% of the patients (n=80), NRAS mutation was found in 2% (n=4), and BRAF mutation was found in 4.1% (n=8). It was determined that there was a statistically significant relationship between KRAS and STAT3 grades of mutations (p<0.05). It is seen that KRAS positivity increases as the STAT3 staining intensity of the patients increases. There was no statistically significant correlation between other mutation results and STAT3 grades. Conclusion:In light of the findings obtained from our study and previous literature, it has been determined that routine STAT3 gene screening is a necessity before the treatment is determined.
{"title":"Effect of STAT3 status on RAS & RAF mutation in patients with metastatic colon carcinoma","authors":"Melin Gecer, Seval Turna, B. Gul, Zuhal Gucin","doi":"10.5455/annalsmedres.2023.04.103","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.04.103","url":null,"abstract":"Objective: Colon adenocarcinomas are the most common gastrointestinal tract malignancy and constitute one of the leading causes of mortality and morbidity worldwide. STAT3 is a transcription factor activated by many cytokines and growth factors and plays a crucial role in cell survival, proliferation, and differentiation. In this research, we aimed to elucidate the molecular properties of colon tumors. Materials & Methods:A total of 196 patients with metastatic colon tumors whose samples were analyzed for KRAS, NRAS, and BFAF between 2016 and 2022 have been investigated in this retrospective study. The samples were analyzed via polymerase chain reaction(PCR)at our institution. STAT3 has been processed to all cases immunohistochemically, and staining intensities were graded.The results were compared with prognostic factors such as tumor molecular characteristics, lymph node status, grade, location, and diameter. Results: A total of 196 patients, 79 (40.3%) female and 117 (59.7%) male, were included in the evaluation within the scope of the study. There was no significant difference between STAT3 staining intensities in terms of demographic characteristics. On the contrary, there was a statistically significant relationship regarding tumor grades (p<0.05). KRAS mutation was found in 40.8% of the patients (n=80), NRAS mutation was found in 2% (n=4), and BRAF mutation was found in 4.1% (n=8). It was determined that there was a statistically significant relationship between KRAS and STAT3 grades of mutations (p<0.05). It is seen that KRAS positivity increases as the STAT3 staining intensity of the patients increases. There was no statistically significant correlation between other mutation results and STAT3 grades. Conclusion:In light of the findings obtained from our study and previous literature, it has been determined that routine STAT3 gene screening is a necessity before the treatment is determined.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87423714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.12.378
A. M. Res, A. Uysal, M. Erkurt, I. Kuku, E. Kaya, İ. Berber, A. Sarici, S. Biçim, Ahmet Kaya, Emine Hidayet, Dagoglu Hark, Süleyman Arslan
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