Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.256
Hilal zsoy, Serhat nal, S. L, Behiye Oral
Objective: This study examines for any differences in the clinical course, laboratory and radiological findings of COVID-19 infection between male, female and pregnant patients in similar age groups. Materials and Methods: This retrospective study involved a review of the data of patients treated between March 2020 and May 2021, included a total of 528 cases (193 pregnant females, 170 non-pregnant females and 165 males) aged 18–40 years with RT-PCR-confirmed COVID-19. Results: A comparison of the three demographically homogeneous groups revealed more common symptomatic infection at admission in the male patient group than in the other two patient groups (p<0.001), as well as a longer hospital stay (p<0.001) and higher incidences of moderate and severe pneumonia (p<0.001) based on radiological findings. In contrast, no significant difference was noted in the intensive care unit admission and mortality rates of the three groups. Conclusion: The results of our study reveal that females have some degree of protection against severe presentations of COVID-19 infection when compared to men. The heterogeneity of immunocompetence and immune response can help to understand the different COVID-19 responses of males and females, and can be used as a guide for disease prognosis and gender-specific treatments.
{"title":"Differences in the clinical course, laboratory and radiological findings of COVID-19 infection between male, female and pregnant patients in demographically homogeneous groups","authors":"Hilal zsoy, Serhat nal, S. L, Behiye Oral","doi":"10.5455/annalsmedres.2022.08.256","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.256","url":null,"abstract":"Objective: This study examines for any differences in the clinical course, laboratory and radiological findings of COVID-19 infection between male, female and pregnant patients in similar age groups. Materials and Methods: This retrospective study involved a review of the data of patients treated between March 2020 and May 2021, included a total of 528 cases (193 pregnant females, 170 non-pregnant females and 165 males) aged 18–40 years with RT-PCR-confirmed COVID-19. Results: A comparison of the three demographically homogeneous groups revealed more common symptomatic infection at admission in the male patient group than in the other two patient groups (p<0.001), as well as a longer hospital stay (p<0.001) and higher incidences of moderate and severe pneumonia (p<0.001) based on radiological findings. In contrast, no significant difference was noted in the intensive care unit admission and mortality rates of the three groups. Conclusion: The results of our study reveal that females have some degree of protection against severe presentations of COVID-19 infection when compared to men. The heterogeneity of immunocompetence and immune response can help to understand the different COVID-19 responses of males and females, and can be used as a guide for disease prognosis and gender-specific treatments.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89222577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.10.300
M. Boz, Abdullah ahin, Mehmet ek
Objective: The current study aimed to compare the arch angles of the foot, Achilles tendinopathy, subcutaneous fat tissue thickness of the heel, and epin calcanei (EC) in patients with osteochondral lesion of the talus (OLT). Methods:The magnetic resonance images (MRI) of the ankle performed by the radiology clinic between March 2020 and October 2021 were examined.Based on the MRI findings, the patients diagnosed with OLT were included in the study group (n = 55) and those not diagnosed with OLT formed the control group (n = 118). All the patients included in the study were investigated for their demographic characteristics and presence of EC. Weight-bearing lateral X-ray images were used to measure the lateral talus-first metatarsal angle (Meary’s angle), lateral talocalcaneal angle (LTCA), and calcaneal inclination angle (also known as the calcaneal pitch). Results: The study and control groups had no significant difference in terms of gender distribution (P = 0.575). The patients in the study group had a significantly higher mean age than the control group (P < 0.001). Evaluation of the arch angles of the foot showed the patients with OLT to have higher LTCA and calcaneal pitch angles and greater subcutaneous fat thicknesses (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, the study group showed higher rates of patients with EC and Achilles tendinopathy (p = 0.076 and p = 0.019, respectively).Conclusion: Our study demonstrated that sex had no effect on OLT incidence, whereas changes in the LTCA and pitch angles elevated the risk of OLT. Furthermore, increased age was found to be associated with a higher risk of OLT formation. We also showed that Achilles tendinopathy and EC were significantly higher in patients with OLT.A considerable number of future studies are needed to establish whether this significant relationship is causal.
{"title":"The relationship between osteochondral lesion of the talus and the foot arch angles in adults: A retrospective study","authors":"M. Boz, Abdullah ahin, Mehmet ek","doi":"10.5455/annalsmedres.2022.10.300","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.300","url":null,"abstract":"Objective: The current study aimed to compare the arch angles of the foot, Achilles tendinopathy, subcutaneous fat tissue thickness of the heel, and epin calcanei (EC) in patients with osteochondral lesion of the talus (OLT). Methods:The magnetic resonance images (MRI) of the ankle performed by the radiology clinic between March 2020 and October 2021 were examined.Based on the MRI findings, the patients diagnosed with OLT were included in the study group (n = 55) and those not diagnosed with OLT formed the control group (n = 118). All the patients included in the study were investigated for their demographic characteristics and presence of EC. Weight-bearing lateral X-ray images were used to measure the lateral talus-first metatarsal angle (Meary’s angle), lateral talocalcaneal angle (LTCA), and calcaneal inclination angle (also known as the calcaneal pitch). Results: The study and control groups had no significant difference in terms of gender distribution (P = 0.575). The patients in the study group had a significantly higher mean age than the control group (P < 0.001). Evaluation of the arch angles of the foot showed the patients with OLT to have higher LTCA and calcaneal pitch angles and greater subcutaneous fat thicknesses (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, the study group showed higher rates of patients with EC and Achilles tendinopathy (p = 0.076 and p = 0.019, respectively).Conclusion: Our study demonstrated that sex had no effect on OLT incidence, whereas changes in the LTCA and pitch angles elevated the risk of OLT. Furthermore, increased age was found to be associated with a higher risk of OLT formation. We also showed that Achilles tendinopathy and EC were significantly higher in patients with OLT.A considerable number of future studies are needed to establish whether this significant relationship is causal.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91527138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.11.333
M. Akyol, E. Çetin
Background: Idiopathic normal pressure hydrocephalus (iNPH) is a surgically reversible neurological disorder in adults. It is a neurological condition characterized by ventricular enlargement detected on cranial imaging as well as gait disturbance, cognitive decline and urinary incontinence, with no other reason to explain the clinical findings. Ventricular shunting, predominantly ventriculoperitoneal (VP) shunt, has been shown to be successful in relieving symptoms in patients. In this study, we aimed to investigate the effects of two VP shunts used in the iNPH patients treated in our clinic. Methods: Clinical and laboratory records of 28 patients who underwent VP shunting due to iNPH were reviewed retrospectively via the Enlyl system. A programmable shunt was inserted in 9 (32.1%) and a medium-pressure shunt was inserted in 19 (67.9%) patients. Results: There was no significant difference between the two shunt types with regard to patient age, gender, and preoperative tests (p>0.05). However, the prevalence of ataxic gait was significantly higher in the Programmable Shunt group compared to the Medium-Pressure Shunt group (p<0.05). On the other hand, no significant difference was found between the shunt types with regard to postoperative examination findings and additional neurological disorders (p>0.05 for both). Conclusion: In the present study, no significant difference was observed between the shunt types with regard to clinical outcomes and thus both types of shunts were revealed as viable options.
{"title":"Effects Of Shunt Types Used In Idiopathic Normal Pressure Hydrocephalus On Patients' Clinical Outcomes","authors":"M. Akyol, E. Çetin","doi":"10.5455/annalsmedres.2022.11.333","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.11.333","url":null,"abstract":"Background: Idiopathic normal pressure hydrocephalus (iNPH) is a surgically reversible neurological disorder in adults. It is a neurological condition characterized by ventricular enlargement detected on cranial imaging as well as gait disturbance, cognitive decline and urinary incontinence, with no other reason to explain the clinical findings. Ventricular shunting, predominantly ventriculoperitoneal (VP) shunt, has been shown to be successful in relieving symptoms in patients. In this study, we aimed to investigate the effects of two VP shunts used in the iNPH patients treated in our clinic. Methods: Clinical and laboratory records of 28 patients who underwent VP shunting due to iNPH were reviewed retrospectively via the Enlyl system. A programmable shunt was inserted in 9 (32.1%) and a medium-pressure shunt was inserted in 19 (67.9%) patients. Results: There was no significant difference between the two shunt types with regard to patient age, gender, and preoperative tests (p>0.05). However, the prevalence of ataxic gait was significantly higher in the Programmable Shunt group compared to the Medium-Pressure Shunt group (p<0.05). On the other hand, no significant difference was found between the shunt types with regard to postoperative examination findings and additional neurological disorders (p>0.05 for both). Conclusion: In the present study, no significant difference was observed between the shunt types with regard to clinical outcomes and thus both types of shunts were revealed as viable options.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90160155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.09.276
ipek ek, Saim Lu, ibrahim ahin
Aim: The goal of this study is to compare the performances of Logistic Regression (LR), Artificial Neural Networks (ANN) and Decision Tree models, which are machine learning classification methods, in the diagnosis of Type 2 Diabetes Mellitus (DM) and to determine the most successful method. It is also the examination of risk factors affecting Type 2 DM using these models. Method: The study's data was collected from patients who visited the Diabetes and Thyroid polyclinic at the Inonu University Faculty of Medicine Turgut Ozal Medical Center, Department of Internal Medicine. The k-Nearest Neighbor algorithm, which is one of the missing value assignment methods, was used to eliminate the problems related to missing values. Sensitivity, accuracy, precision, specificity, AUC F1-score, and classification error were used as performance evaluation criteria. Evolutionary algorithm parameter optimization method was used to optimize the parameters of the ANN model. Missing value assignment, modeling and parameter optimization were done with Rapidminer Studio Free version 8.1. Results: Among the three methods applied in the diagnosis of Type 2 DM, the ANN gave the best classification performance. The accuracy, sensitivity, selectivity, precision, F1-score, AUC and classification error values obtained from this method are respectively; 98.94%, 100%, 97.73%, 98.04%, 99.01%, 0.978 and 1.06. For the ANN method, the importance values of the gender, long-term drug use, family history, concomitant disease, cortisone use, stress factor, high blood pressure, smoking, high cholesterol, heart disease, exercise status, carbohydrate use, alcohol consumption, vegetable use, meat use, age, weight, height, starting age, daily bread consumption, LDL, HDL, Total Cholesterol, Triglyceride, Fasting blood sugar the importance values of independent variables are respectively; 0.017, 0.009, 0.013, 0.017, 0.008, 0.016, 0.008, 0.006, 0.053, 0.024, 0.023, 0.040, 0.007, 0.020, 0.007, 0.046, 0.083, 0.049, 0.024, 0.066, 0.084, 0.083, 0.020, 0.031, 0.244. Conclusion: According to the performance criteria obtained from the three classification models used to predict Type 2 DM; it has been found that the best classification performance belongs to the ANN model. According to the ANN method, the three most important risk factors that may cause Type 2 DM were found to be fasting blood glucose, LDL, and HDL, respectively.
{"title":"A comparison of multivariate statistical methods to detect risk factors for Type 2 diabetes mellitus","authors":"ipek ek, Saim Lu, ibrahim ahin","doi":"10.5455/annalsmedres.2022.09.276","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.276","url":null,"abstract":"Aim: The goal of this study is to compare the performances of Logistic Regression (LR), Artificial Neural Networks (ANN) and Decision Tree models, which are machine learning classification methods, in the diagnosis of Type 2 Diabetes Mellitus (DM) and to determine the most successful method. It is also the examination of risk factors affecting Type 2 DM using these models. Method: The study's data was collected from patients who visited the Diabetes and Thyroid polyclinic at the Inonu University Faculty of Medicine Turgut Ozal Medical Center, Department of Internal Medicine. The k-Nearest Neighbor algorithm, which is one of the missing value assignment methods, was used to eliminate the problems related to missing values. Sensitivity, accuracy, precision, specificity, AUC F1-score, and classification error were used as performance evaluation criteria. Evolutionary algorithm parameter optimization method was used to optimize the parameters of the ANN model. Missing value assignment, modeling and parameter optimization were done with Rapidminer Studio Free version 8.1. Results: Among the three methods applied in the diagnosis of Type 2 DM, the ANN gave the best classification performance. The accuracy, sensitivity, selectivity, precision, F1-score, AUC and classification error values obtained from this method are respectively; 98.94%, 100%, 97.73%, 98.04%, 99.01%, 0.978 and 1.06. For the ANN method, the importance values of the gender, long-term drug use, family history, concomitant disease, cortisone use, stress factor, high blood pressure, smoking, high cholesterol, heart disease, exercise status, carbohydrate use, alcohol consumption, vegetable use, meat use, age, weight, height, starting age, daily bread consumption, LDL, HDL, Total Cholesterol, Triglyceride, Fasting blood sugar the importance values of independent variables are respectively; 0.017, 0.009, 0.013, 0.017, 0.008, 0.016, 0.008, 0.006, 0.053, 0.024, 0.023, 0.040, 0.007, 0.020, 0.007, 0.046, 0.083, 0.049, 0.024, 0.066, 0.084, 0.083, 0.020, 0.031, 0.244. Conclusion: According to the performance criteria obtained from the three classification models used to predict Type 2 DM; it has been found that the best classification performance belongs to the ANN model. According to the ANN method, the three most important risk factors that may cause Type 2 DM were found to be fasting blood glucose, LDL, and HDL, respectively.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88821892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.01.039
Serhat Kaya
Objective: In general, while upper respiratory tract viruses cause flu-like complaints, balance problems associated with these viruses are often overlooked. It has been a long time since the first appearance of Covid-19, but unfortunately, there is still no fully effective treatment for this disease. Along with balance manifestations, especially several vestibular symptoms such as dizziness, vertigo, and tinnitus are described as common clinical manifestations in COVID-19. In our study, we investigated the effects of Covid-19 on the balance system with routine balance tests and we tried to localize a possible disorder in the balance system. Materials and Methods: Volunteers were divided into two groups. The number of volunteers in each group was thirty. The first group consisted of SARS-CoV-2-positive patients and the second group consisted of healthy people. Spontaneous nystagmus determination, Romberg test, Fukuda stepping test (FST), head thrust test (HTT), head shake test (HST), finger-nose test, and tandem walking test were applied. Results: The lateral fall in the Romberg test, rotation in the FST, and nystagmus in the HST are significant in Group 1 (p<0.001), (p<0.001), (p<0.03). The relationship between the fall side in the Romberg test and the direction of rotation in the FST were found to be significant in Group 1 (p<0.001). Similarly, the relationship between the direction of rotation in the FST and the nys-tagmus direction in the HST, and the direction of the saccadic correction in the HTT were found to be sig-nificant (p<0.026), (p<0.010). Conclusion: In SARS-CoV-2 positive patients, the balance system, especially the peripheric vestibular system, may be affected even if the patients do not have obvious complaints about balance. Routine balance tests that can be performed quickly in the outpatient clinic can be used effectively for the evaluation of balance.
{"title":"The relationship between balance and flu-like symptoms: a medical condition that needs attention","authors":"Serhat Kaya","doi":"10.5455/annalsmedres.2023.01.039","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.039","url":null,"abstract":"Objective: In general, while upper respiratory tract viruses cause flu-like complaints, balance problems associated with these viruses are often overlooked. It has been a long time since the first appearance of Covid-19, but unfortunately, there is still no fully effective treatment for this disease. Along with balance manifestations, especially several vestibular symptoms such as dizziness, vertigo, and tinnitus are described as common clinical manifestations in COVID-19. In our study, we investigated the effects of Covid-19 on the balance system with routine balance tests and we tried to localize a possible disorder in the balance system. Materials and Methods: Volunteers were divided into two groups. The number of volunteers in each group was thirty. The first group consisted of SARS-CoV-2-positive patients and the second group consisted of healthy people. Spontaneous nystagmus determination, Romberg test, Fukuda stepping test (FST), head thrust test (HTT), head shake test (HST), finger-nose test, and tandem walking test were applied. Results: The lateral fall in the Romberg test, rotation in the FST, and nystagmus in the HST are significant in Group 1 (p<0.001), (p<0.001), (p<0.03). The relationship between the fall side in the Romberg test and the direction of rotation in the FST were found to be significant in Group 1 (p<0.001). Similarly, the relationship between the direction of rotation in the FST and the nys-tagmus direction in the HST, and the direction of the saccadic correction in the HTT were found to be sig-nificant (p<0.026), (p<0.010). Conclusion: In SARS-CoV-2 positive patients, the balance system, especially the peripheric vestibular system, may be affected even if the patients do not have obvious complaints about balance. Routine balance tests that can be performed quickly in the outpatient clinic can be used effectively for the evaluation of balance.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83085672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.03.067
Bar Zorbozan, M. Yener, Belgin Bama
{"title":"Changes in Motor and Sensory Parameters in Patients with Lumbar Disc Herniation","authors":"Bar Zorbozan, M. Yener, Belgin Bama","doi":"10.5455/annalsmedres.2023.03.067","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.03.067","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82014496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.02.043
O. Ozhan, ipek ek, Zeynep Al
Aim: To classify angina pectoris (AP) in women by applying the Bagged CART approach, which is one of the machine learning (ML) methods, to the open-access AP dataset. Another aim is to reveal the risk factors associated with AP in women through modeling. Materials and Methods: In the current study, modeling was done with the Bagged CART technique utilizing an open-access data set containing the factors associated with AP. Model results were assessed with accuracy (ACC), sensitivity (Sen), balanced accuracy (BACC), positive predictive value (PPV), specificity (Spe), negative predictive value (NPV), and F1-score performance criteria. In addition, a 5-fold cross-validation approach was applied in the modeling phase. Finally, variable importance was derived with modeling. Results: ACC, BACC, Sen, Spe, PPV, NPV, and F1-score from Bagged CART modeling were 98.5%, 98.5%, 99.0%, 98.0%, 98.0%, 99.0%, and 98.5%, respectively. Depending on the variable importance values calculated for the input variables investigated in the current study, age, family history of myocardial infarction: yes, the average number of cigarettes smoked per day smoking status: current, family history of angina: yes, hypertensive condition: moderate, smoking status: ex, hypertensive condition: mild, family history of stroke: yes, whether the woman has diabetes: yes were obtained as the most important variables associated with AP. Conclusion: With the ML model used, the AP dataset was classified successfully, and the associated risk factors were revealed. ML models can be used as clinical decision support systems for early diagnosis and treatment.
{"title":"Analyzing And Detecting Risk Factors For The Diagnosis Of Angina Pectoris With Machine Learning","authors":"O. Ozhan, ipek ek, Zeynep Al","doi":"10.5455/annalsmedres.2023.02.043","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.043","url":null,"abstract":"Aim: To classify angina pectoris (AP) in women by applying the Bagged CART approach, which is one of the machine learning (ML) methods, to the open-access AP dataset. Another aim is to reveal the risk factors associated with AP in women through modeling. Materials and Methods: In the current study, modeling was done with the Bagged CART technique utilizing an open-access data set containing the factors associated with AP. Model results were assessed with accuracy (ACC), sensitivity (Sen), balanced accuracy (BACC), positive predictive value (PPV), specificity (Spe), negative predictive value (NPV), and F1-score performance criteria. In addition, a 5-fold cross-validation approach was applied in the modeling phase. Finally, variable importance was derived with modeling. Results: ACC, BACC, Sen, Spe, PPV, NPV, and F1-score from Bagged CART modeling were 98.5%, 98.5%, 99.0%, 98.0%, 98.0%, 99.0%, and 98.5%, respectively. Depending on the variable importance values calculated for the input variables investigated in the current study, age, family history of myocardial infarction: yes, the average number of cigarettes smoked per day smoking status: current, family history of angina: yes, hypertensive condition: moderate, smoking status: ex, hypertensive condition: mild, family history of stroke: yes, whether the woman has diabetes: yes were obtained as the most important variables associated with AP. Conclusion: With the ML model used, the AP dataset was classified successfully, and the associated risk factors were revealed. ML models can be used as clinical decision support systems for early diagnosis and treatment.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90540835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.171
Serkan GUVEN, Sevil ALKAN
Aim: Primary central nervous system lymphoma (PCNSL) is an important topic in hematology due to its rare, aggressive course, difficult diagnosis and special treatment requirements. This bibliometric analysis study aimed to examine PCNSL -related publications published since the last 2000 and to identify potential points of future research. Material and methods: Web of Science Core Collection documents published between 2000 and 2022 were analyzed using selected keywords. The obtained data were visualized with bibliometric tools. Publishing countries, organizations, journals, authors, references, and keywords were all examined comprehensively. Results: 1,160 articles on PCNSL published since 2000 were retrieved. These publications tend to focus on research in oncology (n=456, 39.310%), clinical neurology (n=354, 30.517%), and hematology (n=173, 14.914%). Search criteria revealed that 6,458 authors from 65 different countries and 1,570 organizations worldwide contributed to PCNSL articles. Conclusion: Studying research on PCNSL is crucial to improve our knowledge of this disease and to create new treatment strategies. It is very important to keep in mind that the characteristics and trends in PCNSL research may change over time as new findings and developments in the field are discovered.
目的:原发性中枢神经系统淋巴瘤(Primary central nervous system lymphoma, PCNSL)因其罕见、病程严重、诊断困难、治疗要求特殊而成为血液学研究的重要课题。本文献计量分析研究旨在检查自2000年以来出版的PCNSL相关出版物，并确定未来研究的潜在点。材料与方法:选取关键词对2000 - 2022年间发表的Web of Science Core Collection文献进行分析。用文献计量学工具对所得数据进行可视化处理。出版国家、组织、期刊、作者、参考文献和关键词都被全面审查。结果:检索到2000年以来发表的PCNSL论文1160篇。这些出版物往往集中在肿瘤学(n= 456,39.310%)、临床神经病学(n= 354,30.517%)和血液学(n=173, 14.914%)方面的研究。搜索结果显示，来自65个不同国家和1570个组织的6458位作者为PCNSL贡献了文章。结论:研究PCNSL对提高我们对该病的认识和制定新的治疗策略至关重要。重要的是要记住，随着新发现和新发展的发现，PCNSL研究的特点和趋势可能会随着时间的推移而改变。
{"title":"Bibliometric analysis of primary central nervous system lymphoma","authors":"Serkan GUVEN, Sevil ALKAN","doi":"10.5455/annalsmedres.2023.08.171","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.171","url":null,"abstract":"Aim: Primary central nervous system lymphoma (PCNSL) is an important topic in hematology due to its rare, aggressive course, difficult diagnosis and special treatment requirements. This bibliometric analysis study aimed to examine PCNSL -related publications published since the last 2000 and to identify potential points of future research. Material and methods: Web of Science Core Collection documents published between 2000 and 2022 were analyzed using selected keywords. The obtained data were visualized with bibliometric tools. Publishing countries, organizations, journals, authors, references, and keywords were all examined comprehensively. Results: 1,160 articles on PCNSL published since 2000 were retrieved. These publications tend to focus on research in oncology (n=456, 39.310%), clinical neurology (n=354, 30.517%), and hematology (n=173, 14.914%). Search criteria revealed that 6,458 authors from 65 different countries and 1,570 organizations worldwide contributed to PCNSL articles. Conclusion: Studying research on PCNSL is crucial to improve our knowledge of this disease and to create new treatment strategies. It is very important to keep in mind that the characteristics and trends in PCNSL research may change over time as new findings and developments in the field are discovered.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.184
Mesut YUR
Objective: The most common type of cancer in women is breast cancer. Despite an increase in the rate of early detection, distant organ metastasis is still seen at the time of diagnosis. The purpose of this study was to identify the predictive risk factors for breast cancer patients with distant organ metastases and to compare them to those without distant organ metastases. Materials and Methods: The study included data from patients who applied to our clinic for follow-up or treatment between January 2020 and July 2020. After meeting the exclusion criteria, the remaining 115 patients were included in the study. Study participants were divided into two groups: metastatic (group I) and non-metastatic (group II). Logistic regression analysis is used to assess the predictive risk factors. Results: There is a significant difference between groups in terms of the breast side, T-stage, N-stage, CA 15-3, and albumin levels (p< 0.05). In univariate analyses, T-stage, CA 15-3, estimates glomerular filtration rate (eGFR), alkaline phosphatase, and albumin levels were statistically found to be significant (p<0.05). In multivariate analysis, CA 15-3 (OR: 1.017; 95% CI: 1.005-1.030, p = 0.006), eGFR (OR: 0.944; 95% CI: 0.894-0.996, p = 0.034), and albumin (OR: 0.087; 95% CI: 0.011-0.676, p = 0.020) were found to be predictive risk factors for metastatic breast cancer. Conclusion: High T-stage, N positivity, high CA15-3 levels, and low albumin levels were observed in the metastatic breast cancer group. CA 15-3, eGFR, and albumin levels were found to be predictive factors for metastatic breast cancer at the initial diagnosis. New studies are needed to validate these findings.
目的:女性中最常见的癌症类型是乳腺癌。尽管早期发现率有所增加，但在诊断时仍然可以看到远处器官转移。本研究的目的是确定乳腺癌远处器官转移患者的预测危险因素，并将其与未发生远处器官转移的患者进行比较。材料和方法:本研究纳入了2020年1月至2020年7月期间到我们诊所申请随访或治疗的患者的数据。符合排除标准后，其余115例患者纳入研究。研究参与者分为两组:转移性(I组)和非转移性(II组)。采用Logistic回归分析来评估预测的危险因素。结果:两组患者在乳腺侧、t期、n期、ca15 -3、白蛋白水平(p<0.05)。在单变量分析中，t期，CA 15-3，估计肾小球滤过率(eGFR)，碱性磷酸酶和白蛋白水平具有统计学意义(p<0.05)。在多变量分析中，CA 15-3 (OR: 1.017;95% CI: 1.005-1.030, p = 0.006)， eGFR (OR: 0.944;95% CI: 0.894-0.996, p = 0.034)，白蛋白(OR: 0.087;95% CI: 0.011-0.676, p = 0.020)为转移性乳腺癌的预测危险因素。结论:转移性乳腺癌组t分期高，N阳性，CA15-3水平高，白蛋白水平低。CA 15-3、eGFR和白蛋白水平在最初诊断时被发现是转移性乳腺癌的预测因素。需要新的研究来验证这些发现。
{"title":"Comparison of metastatic versus non-metastatic breast cancer at the time of diagnosis and risk factors for primary metastatic breast cancer","authors":"Mesut YUR","doi":"10.5455/annalsmedres.2023.08.184","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.184","url":null,"abstract":"Objective: The most common type of cancer in women is breast cancer. Despite an increase in the rate of early detection, distant organ metastasis is still seen at the time of diagnosis. The purpose of this study was to identify the predictive risk factors for breast cancer patients with distant organ metastases and to compare them to those without distant organ metastases. Materials and Methods: The study included data from patients who applied to our clinic for follow-up or treatment between January 2020 and July 2020. After meeting the exclusion criteria, the remaining 115 patients were included in the study. Study participants were divided into two groups: metastatic (group I) and non-metastatic (group II). Logistic regression analysis is used to assess the predictive risk factors. Results: There is a significant difference between groups in terms of the breast side, T-stage, N-stage, CA 15-3, and albumin levels (p< 0.05). In univariate analyses, T-stage, CA 15-3, estimates glomerular filtration rate (eGFR), alkaline phosphatase, and albumin levels were statistically found to be significant (p<0.05). In multivariate analysis, CA 15-3 (OR: 1.017; 95% CI: 1.005-1.030, p = 0.006), eGFR (OR: 0.944; 95% CI: 0.894-0.996, p = 0.034), and albumin (OR: 0.087; 95% CI: 0.011-0.676, p = 0.020) were found to be predictive risk factors for metastatic breast cancer. Conclusion: High T-stage, N positivity, high CA15-3 levels, and low albumin levels were observed in the metastatic breast cancer group. CA 15-3, eGFR, and albumin levels were found to be predictive factors for metastatic breast cancer at the initial diagnosis. New studies are needed to validate these findings.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135802054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.05.124
Arzu c, Selin Alp, lknur Akta, P nar, Feyza zkan
Aim: Spasticity that occurs after a stroke may contribute to disability. Botulinum toxin type-A (BTX-A) injections are commonly used to manage spasticity. This study sought to determine the effectiveness of BTX-A injections on spasticity and motor recovery in patients with stroke. Materials and Methods: Twenty-five patients with stroke scheduled for BTX-A injection for spasticity were included in the study. The patients were analyzed in two groups: upper limb and lower limb group. A single dose of BTX-A was applied to the patients. Before, 2, and 12 weeks after BTX-A injections, motor function was assessed using Brunnstrom recovery stages, and spasticity was evaluated according to Modified Ashworth Scale (MAS). The lower limb group additionally underwent the Functional Ambulation Classification (FAC) and 10-meter walking test. Results: Mean age of patients was 54.96 ± 12.84 years. Eighteen patients were enrolled in the upper limb group and 23 in the lower limb group. Clinical evaluation of the upper limb group two weeks after injections demonstrated a significant decrease in shoulder adductor muscle MAS, elbow, wrist, and finger flexor muscles MAS, and a significant improvement in Brunnstrom recovery stages for the upper limb and hand (p<0.05). At week 12, spasticity decreased only for the shoulder adductor muscles. In the lower limb group, clinical evaluation at week 2 showed a decrease in the knee extensor and toe flexor muscles MAS. Assessment of the patients at week 12 found a significant improvement in Brunnstrom recovery stage for the lower limbs (p<0.05). There was no statistically significant recovery in the FAC and 10-meter walking test (p>0.05). Conclusion: This study supports that BTX-A injections are effective for improving spasticity and motor function in patients with stroke.
{"title":"Botulinum toxin-A injection improves motor recovery in patients with stroke","authors":"Arzu c, Selin Alp, lknur Akta, P nar, Feyza zkan","doi":"10.5455/annalsmedres.2023.05.124","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.124","url":null,"abstract":"Aim: Spasticity that occurs after a stroke may contribute to disability. Botulinum toxin type-A (BTX-A) injections are commonly used to manage spasticity. This study sought to determine the effectiveness of BTX-A injections on spasticity and motor recovery in patients with stroke. Materials and Methods: Twenty-five patients with stroke scheduled for BTX-A injection for spasticity were included in the study. The patients were analyzed in two groups: upper limb and lower limb group. A single dose of BTX-A was applied to the patients. Before, 2, and 12 weeks after BTX-A injections, motor function was assessed using Brunnstrom recovery stages, and spasticity was evaluated according to Modified Ashworth Scale (MAS). The lower limb group additionally underwent the Functional Ambulation Classification (FAC) and 10-meter walking test. Results: Mean age of patients was 54.96 ± 12.84 years. Eighteen patients were enrolled in the upper limb group and 23 in the lower limb group. Clinical evaluation of the upper limb group two weeks after injections demonstrated a significant decrease in shoulder adductor muscle MAS, elbow, wrist, and finger flexor muscles MAS, and a significant improvement in Brunnstrom recovery stages for the upper limb and hand (p<0.05). At week 12, spasticity decreased only for the shoulder adductor muscles. In the lower limb group, clinical evaluation at week 2 showed a decrease in the knee extensor and toe flexor muscles MAS. Assessment of the patients at week 12 found a significant improvement in Brunnstrom recovery stage for the lower limbs (p<0.05). There was no statistically significant recovery in the FAC and 10-meter walking test (p>0.05). Conclusion: This study supports that BTX-A injections are effective for improving spasticity and motor function in patients with stroke.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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