Archives of Medical Research最新文献_第5页

Does Baseline Autonomic Nervous System Activity Affect the Outcomes of Transcutaneous Auricular Vagus Nerve Stimulation? 自主神经系统基线活动是否影响经皮耳迷走神经刺激的结果？

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-18 DOI: 10.1016/j.arcmed.2025.103324

Alper Percin , Ali Veysel Ozden , Semiha Yenisehir , Berkay Eren Pehlivanoglu , Ramazan Cihad Yılmaz

Aim

Transcutaneous auricular vagus nerve stimulation (taVNS) has recently emerged as an effective neuromodulation method. A preliminary evaluation based on heart rate variability (HRV) could predict those who would benefit most from taVNS. This study investigated the efficacy of taVNS in healthy subjects according to the baseline activity range of the parasympathetic (PNS) and sympathetic nervous system (SNS) indexes.

Methods

76 healthy participants were enrolled in the study. HRV, pulse rate, and systolic and diastolic blood pressure (SBP and DBP) were measured at baseline and after taVNS. The procedure was repeated after 48–72 h.

Results

In the first intervention, the PNS index increased in group 1 (p <0.001), and the SNS index decreased in groups 1 and 3 (p <0.001). In the second intervention, the PNS index increased in groups 1, 2, and 4 (p = 0.001, p = 0.018, and p = 0.003, respectively), while the SNS index decreased in groups 1 and 3 (both p = 0.001). SBP and DBP decreased in all groups after both interventions. After the first intervention, the PNS index was higher in group 1 than in groups 3 and 4 (p = 0.001 and p <0.001, respectively), and the SNS index and SBP were lower in group 1 than in group 3 (both p <0.05). After the second intervention, the PNS index was higher and the SNS index was lower in group 1 than in group 3 (p <0.05).

Conclusions

Subjects with low parasympathetic or high sympathetic activity may be more responsive to taVNS.

目的：经皮耳迷走神经刺激（taVNS）是近年来出现的一种有效的神经调节方法。基于心率变异性（HRV）的初步评估可以预测哪些人将从taVNS中获益最多。本研究根据副交感神经系统（PNS）和交感神经系统（SNS）指标的基线活动范围，考察taVNS在健康受试者中的疗效。方法：76名健康受试者参与研究。在基线和taVNS后分别测量HRV、脉搏率、收缩压和舒张压（SBP和DBP）。结果：在第一次干预中，第1组PNS指数升高(p)。结论：副交感神经活动低或交感神经活动高的受试者可能对taVNS更敏感。

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引用次数: 0

Phase Angle/C-reactive Protein-Index as a Novel Combined Tool for Predicting Liver-Related Hospitalizations in MASLD-Decompensated Cirrhosis 相位角/ c反应蛋白指数作为预测masld失代偿肝硬化患者肝脏相关住院的新组合工具

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-18 DOI: 10.1016/j.arcmed.2025.103306

Marcello Dallio , Mario Romeo , Annachiara Coppola, Giuseppina Martinelli, Claudio Basile, Fiammetta Di Nardo, Carmine Napolitano, Paolo Vaia, Alessia De Gregorio, Alessia Silvestrin, Giusy Senese, Alessandro Federico

Background

Phase angle (PA), a bioelectrical impedance analysis (BIA)-assessable marker of sarcopenia, can accurately predict hospitalizations in advanced chronic liver disease (ACLD). PA has never been specifically investigated in metabolic dysfunction-associated steatotic liver disease (MASLD). Sarcopenia is commonly observed in patients with MASLD, whereas individuals with compensated ACLD (cACLD)-MASLD progress more rapidly to decompensated ACLD (dACLD).

Aims

To evaluate the PA values across the different stages of liver disease progression in MASLD, and to estimate the accuracy of the novel PA/C-reactive-protein (CRP) index (PAC-I) in predicting 3 month further liver-related events (LREs) and hospitalizations in MASLD-dACLD.

Methods

Patients with MASLD were consecutively enrolled and stratified according to liver stiffness measurement (LSM) and eventual previous LREs in ≤F3 fibrosis (AF), cACLD, and dACLD. At baseline, anthropobiochemical, nutritional, and clinical data were collected. Patients with MASLD-dACLD were followed up, and further LRE-determining hospitalizations within the subsequent three months were recorded.

Results

In patients with MASLD, PA values were inversely correlated with LSM, and progressively decreased according to the worsening of liver disease (cACLD vs. dACLD, p <0.0001). In patients with dACLD, PA inversely correlated with CRP levels. PAC-I showed greater accuracy and superiority compared to PA alone in predicting the occurrence of further LREs within three months (PAC-I <2.35: optimal cut-off). Consistently, patients with dACLD with PAC-I <2.35 presented a higher risk of further LREs.

Conclusions

In MASLD, PA correlates with disease progression status. PAC-I represents a useful noninvasive tool in predicting short-term liver-related hospitalizations in dACLD.

背景：相位角（PA）是一种生物电阻抗分析（BIA）可评估的肌肉减少症标志物，可以准确预测晚期慢性肝病（ACLD）的住院情况。PA在代谢功能障碍相关的脂肪变性肝病（MASLD）中从未被专门研究过。肌少症在MASLD患者中很常见，而代偿性ACLD (cACLD)-MASLD患者发展到失代偿性ACLD （dACLD）的速度更快。目的：评估MASLD肝病进展不同阶段的PA值，并评估新型PA/ c -反应蛋白（CRP）指数（PAC-I）预测MASLD- dacld 3个月进一步肝脏相关事件（LREs）和住院的准确性。方法：根据肝硬度测量（LSM）和≤F3纤维化（AF）、cACLD和dACLD的最终LREs，对MASLD患者进行连续入组和分层。基线时，收集人体生化、营养和临床数据。对masld - dld患者进行随访，并在随后的三个月内记录进一步确定lre的住院情况。结果：在MASLD患者中，PA值与LSM呈负相关，并随着肝病的恶化而逐渐降低（cACLD vs. dACLD, p）。结论：在MASLD中，PA与疾病进展状态相关。pac - 1是预测dACLD短期肝脏相关住院的一种有用的无创工具。

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引用次数: 0

Sleep as a Mediator: Decoding the Complex Relationship Between Coffee, Exercise, and Semen quality 睡眠作为中介：解读咖啡、运动和精液质量之间的复杂关系。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-18 DOI: 10.1016/j.arcmed.2025.103317

Yu Liu , Wenrui Lu , Guanxiang Yuan , Qi Zhou , Benhong Xu , Jianjun Liu , Peiyi Liu

Objectives

Given the global decline in semen quality, it is crucial to investigate the modifiable factors, such as lifestyle that influence semen quality in men. This cross-sectional observational study evaluated the association between coffee intake, physical activity, sleep, and semen quality.

Methods

A total of 3,302 male participants, aged 18–60 years, underwent urological assessments, provided semen samples, and participated in anthropometric measurements and a questionnaire addressing lifestyle factors related to semen quality. A multiple linear regression model was used to examine the associations between coffee consumption, physical activity, sleep, and semen quality. Furthermore, mediation models were developed to explore the potential mediating role of sleep in the relationship between coffee intake, physical activity, and semen quality.

Results

The results showed that not drinking coffee was positively associated with the sperm total motility rate, and the sperm progressive motility rate, and negatively associated with the sperm immotility rate. Physical activity was also positively correlated with semen volume. Subgroup analysis showed that physical activity mitigated the effect of coffee on semen quality. In addition, mediation analysis revealed that the time of falling asleep mediated the relationship between coffee consumption and semen quality. Moreover, the average duration of nightly sleep mediated the relationship between physical activity and various semen motility parameters.

Conclusions

The associations among coffee intake, physical activity, sleep and semen quality were statistically significant. These findings highlight the importance of a healthy lifestyle for optimal male semen quality.

目的：鉴于全球精液质量下降，研究影响男性精液质量的可改变因素（如生活方式）至关重要。这项横断面观察性研究评估了咖啡摄入量、身体活动、睡眠和精液质量之间的关系。方法：共有3302名年龄在18-60岁的男性参与者接受了泌尿科评估，提供了精液样本，并参与了人体测量和与精液质量相关的生活方式因素的问卷调查。研究人员使用多元线性回归模型来检验咖啡摄入量、身体活动、睡眠和精液质量之间的关系。此外，研究人员还建立了中介模型，以探索睡眠在咖啡摄入量、身体活动和精液质量之间的潜在中介作用。结果：不喝咖啡与精子总运动率、精子渐进运动率呈正相关，与精子不运动率呈负相关。体力活动也与精液量呈正相关。亚组分析显示，体育活动减轻了咖啡对精液质量的影响。此外，中介分析显示，入睡时间介导了咖啡消费量与精液质量之间的关系。此外，平均每晚睡眠时间介导了体力活动与各种精液运动参数之间的关系。结论：咖啡摄入量、体力活动、睡眠和精液质量之间的关联具有统计学意义。这些发现强调了健康的生活方式对最佳男性精液质量的重要性。

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引用次数: 0

Controlled Ovarian Stimulation Contributes to the Incidence of de Novo Chromosomal Abnormalities in Cleavage-Stage Embryos 控制卵巢刺激有助于卵裂期胚胎新生染色体异常的发生率。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-18 DOI: 10.1016/j.arcmed.2025.103318

Yinghui Ye , Jieliang Ma , Qitao Zhan , Ruimin Zhao , Xinyun Yang , Yangyun Zou , Fan Jin

Background

Studies on the effects of ovarian stimulation on the embryo aneuploidy rate have shown conflicting results.

Objectives

To investigate whether parameters of controlled ovarian stimulation (COS) are associated with the incidence of de novo chromosomal abnormalities in cleavage-stage embryos undergoing preimplantation genetic testing (PGT).

Methods

This retrospective study examined data from biopsies of cleavage-stage embryos with one blastomere from the Women’s Hospital at Zhejiang University School of Medicine. De novo chromosomal abnormalities were classified as: de novo chromosomal segmental abnormalities (DCSAs) or de novo whole chromosomal abnormalities (DWCAs). A multivariable logistic regression model was used to identify factors that may affect the genomic stability of embryos. Further stratification analysis was performed to explore the impact of these factors on DCSAs and DWCAs.

Results

A total of 1,994 cleavage-stage biopsied embryos were included in the analysis. The number of DWCAs but not DCSAs increased significantly with maternal age. The incidence of de novo chromosomal abnormalities was similar between different COS protocols. Longer stimulation duration was associated with a considerably higher DWCA rate (p = 0.003). The DCSA rate increased with higher gonadotropin dosages. Furthermore, cotreatment with growth hormone (GH) supplementation was associated with a significantly lower incidence of DWCAs (p = 0.006).

Conclusion

Ovarian stimulation parameters are related to the incidence of de novo chromosomal abnormalities in preimplantation embryos. GH supplementation had a beneficial effect in decreasing aneuploidy, and higher gonadotropin doses may be related to mitotic errors.

背景：卵巢刺激对胚胎非整倍体率影响的研究结果相互矛盾。目的：探讨卵裂期胚胎植入前基因检测（PGT）中控制性卵巢刺激（COS）参数是否与新生染色体异常发生率相关。方法：本回顾性研究检查了浙江大学医学院妇女医院卵裂期胚胎的活组织检查数据。新生染色体异常分为：新生染色体节段异常（DCSAs）和新生全染色体异常（DWCAs）。采用多变量logistic回归模型确定可能影响胚胎基因组稳定性的因素。进一步进行分层分析，探讨这些因素对DCSAs和DWCAs的影响。结果：共1994个卵裂期活检胚胎被纳入分析。随着母亲年龄的增长，dwca的数量显著增加，而DCSAs的数量没有显著增加。不同COS方案的新发染色体异常发生率相似。较长的刺激时间与较高的DWCA率相关（p = 0.003）。随着促性腺激素剂量的增加，DCSA发生率增加。此外，与生长激素（GH）补充共同治疗与DWCAs发生率显著降低相关（p = 0.006）。结论：卵巢刺激参数与着床前胚胎新生染色体异常发生率有关。生长激素补充对减少非整倍体有有益作用，高促性腺激素剂量可能与有丝分裂错误有关。

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引用次数: 0

Regulation of Intestinal Permeability in Health and Disease: Possible Therapeutic Applications 肠道通透性在健康和疾病中的调节：可能的治疗应用。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-17 DOI: 10.1016/j.arcmed.2025.103321

Azmavet M. Güemes-González , Lourdes A. Arriaga-Pizano , Rommel Chacón-Salinas , Isabel Wong-Baeza , Eduardo Ferat-Osorio

Intestinal permeability is the process by which certain substances pass through the intestinal barrier and enter the bloodstream to reach the tissues and organs where they are needed. This vital process is regulated by various physiological mechanisms, depending on the type of molecule being translocated, from ions and water molecules to large peptides and vitamins. However, under certain conditions, intestinal permeability can increase, exposing the body to the passage of unwanted molecules and pathogenic microorganisms. The various mechanisms involved in increased intestinal permeability include the zonulin pathway, intestinal epithelial cell death, intestinal dysbiosis, and transcytosis. Each of these mechanisms is activated by certain stimuli, and may occur in isolation or together. The translocation of molecules and pathogens has been linked to the development or worsening of certain pathologies, such as acute pancreatitis, sepsis, inflammatory bowel diseases, irritable bowel syndrome, celiac disease, systemic lupus erythematosus, obesity, depression, and schizophrenia. This is mainly due to the inflammatory response generated in response to the translocated microorganisms. Research has been conducted to develop therapies to decrease intestinal permeability in several diseases. This review summarizes knowledge related to pathways that regulate intestinal permeability, diseases associated with increased intestinal permeability, and advances in potential treatments.

肠道渗透性是指某些物质通过肠道屏障进入血液，到达需要它们的组织和器官的过程。这一重要过程受到多种生理机制的调节，取决于被转运的分子类型，从离子和水分子到大肽和维生素。然而，在某些条件下，肠道通透性会增加，使身体暴露于不需要的分子和致病微生物的通道中。肠通透性增加的各种机制包括带蛋白途径、肠上皮细胞死亡、肠道生态失调和胞吞作用。这些机制中的每一个都被特定的刺激激活，可能单独发生，也可能一起发生。分子和病原体的易位与某些疾病的发展或恶化有关，如急性胰腺炎、败血症、炎症性肠病、肠易激综合征、乳糜泻、系统性红斑狼疮、肥胖、抑郁和精神分裂症。这主要是由于易位微生物引起的炎症反应。已经进行了研究，以开发治疗降低肠道通透性的几种疾病。本文综述了调节肠通透性的途径、与肠通透性增加相关的疾病以及潜在治疗的进展。

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引用次数: 0

Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression through the Modulation of Membrane Lipid Rafts 细胞内半乳糖凝集素-3通过调节膜脂筏调控泡沫细胞形成和凋亡进程

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-09 DOI: 10.1016/j.arcmed.2025.103300

Wen-cheng Liu , Chin-sheng Lin , Chen-ling Luo , Weng-yu Yang , Cheng-hung Yang , Mei-Ling Cheng , Min-chien Tsai , Wei-shiang Lin , Hao-ai Shui , Yi-ping Chuang

Background

Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages. However, its impact on inflammation remains controversial.

Methods

An in vitro model using human THP-1-derived macrophages was established to simulate inflammatory foam cells. CRISPR-Cas9-assisted LGALS3 knockout in THP-1 cells was performed to elucidate the functional role of Gal-3 in inflammation and apoptosis.

Results

OxLDL-internalized THP-1-derived foam cells secreted significant Gal-3 upon lipopolysaccharide (LPS) treatment, mimicking elevated Gal-3 levels observed in patients with CVD. LPS-treated foam cells showed Gal-3-dependent inflammation, endoplasmic reticulum stress, and apoptosis progression. LGALS3 knockout reduced oxLDL uptake and inflammation, accompanied by decreased surface expression of CD36 and CD14. This indicates a disrupted lipid raft structure, as confirmed by reduced cholera toxin B subunit recognition and altered sphingolipid profile. Gal-3 inhibitors GB1107 and TD139 attenuated LPS-induced cytokine production. Notably, only GB1107 inhibited oxLDL uptake by partially disrupting lipid raft organization, due to its superior membrane permeability. GB1107 further altered Gal-3 nuclear localization under LPS or oxLDL exposure, suggesting a potential nuclear role during inflammation. Importantly, GB1107 reduced foam cell formation in primary human monocyte-derived macrophages, supporting its translational relevance.

Conclusions

Gal-3 modulates lipid raft organization and oxLDL internalization, acting as a pro-inflammatory mediator in foam cell biology. These findings highlight Gal-3 as a potential therapeutic target for early atherosclerosis.

背景：动脉粥样硬化是全球心血管疾病（CVD）死亡的主要原因，其特征是脂质代谢失调和未解决的炎症。巨噬细胞衍生泡沫细胞的形成和凋亡有助于斑块的形成和脆弱性。血清半乳糖凝集素-3 （Gal-3）水平升高与CVD风险增加相关，斑块中的Gal-3与巨噬细胞密切相关。然而，它对炎症的影响仍然存在争议。方法采用人thp -1源性巨噬细胞模拟炎性泡沫细胞，建立体外模型。通过crispr - cas9辅助敲除THP-1细胞中的LGALS3来阐明Gal-3在炎症和细胞凋亡中的功能作用。结果soxldl内化thp -1衍生泡沫细胞在脂多糖（LPS）处理下分泌显著的Gal-3，模拟CVD患者Gal-3水平升高。lps处理的泡沫细胞表现出gal -3依赖性炎症、内质网应激和细胞凋亡进展。LGALS3敲除可减少oxLDL摄取和炎症，并伴有CD36和CD14表面表达降低。这表明脂质筏结构被破坏，正如霍乱毒素B亚基识别减少和鞘脂谱改变所证实的那样。Gal-3抑制剂GB1107和TD139可减弱lps诱导的细胞因子产生。值得注意的是，由于其优越的膜通透性，只有GB1107通过部分破坏脂筏组织来抑制oxLDL的摄取。在LPS或oxLDL暴露下，GB1107进一步改变了Gal-3的核定位，表明其在炎症过程中可能具有核作用。重要的是，GB1107减少了原代人单核细胞源性巨噬细胞中的泡沫细胞形成，支持其翻译相关性。结论sgal -3调节脂质筏组织和oxLDL内化，在泡沫细胞生物学中起促炎介质作用。这些发现强调了Gal-3作为早期动脉粥样硬化的潜在治疗靶点。

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引用次数: 0

Maternal Phthalate Exposure Alters Prostate Proteome in Rat Offspring: Linking Omics Insights to Prostate Cancer Risk in Humans 母体邻苯二甲酸盐暴露改变大鼠后代前列腺蛋白质组：将组学见解与人类前列腺癌风险联系起来

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-07 DOI: 10.1016/j.arcmed.2025.103297

Patrick Vieira Souza , Ariana Musa Aquino , Luiz Guilherme Alonso-Costa , Natália Magosso , Marcos Antonio Fernandes de Oliveira , Vanessa Aguiar Rocha , Matheus Naia Fioretto , Mirella Franco Moreira , Victória Cristina Pinha , Gabriel Henrique Caxali , Luis Antônio Justulin , Jodi Anne Flaws , Wellerson Rodrigo Scarano

Background

Phthalates are compounds used as plasticizers to increase the flexibility of plastics and are considered endocrine disruptors. Some studies suggest that the origin of prostate cancer (PCa) may be associated with disturbances during embryo-fetal development. Previous data showed that perinatal exposure to the same phthalate mixture (PM) used here increased the incidence of adenocarcinomas in the prostates of aged rats. Building on our earlier work, this study identifies proteins altered in the prostate proteome by exposure to a PM during gestation and lactation in rats, focusing on proteins in the human secretome and their correlation with PCa.

Methods

Pregnant SD rats were divided into three groups and treated from gestational day (GD)10 to postnatal day (PND)21. On PND22 the differentially abundant proteins in the offspring’s prostate were compared with the predicted secreted proteins in humans. Then, the abundance of selected proteins was compared among groups and enriched. Finally, a protein-protein interaction network was obtained. The resulting data were cross-referenced with data for PCa and some targets were validated by RT-qPCR and Western blot.

Results

Perinatal exposure to PM affected the endoplasmic reticulum, decreasing the amount of certain proteins crucial for protein folding and secretion, impairing secretion of several proteins important for proper prostate development. Furthermore, in silico analysis revealed that several proteins in the rat proteome are also altered in patients with PCa.

Conclusions

Our results suggest that early exposure to phthalates may modulate protein secretion, creating a microenvironment that impairs tissue development and increases susceptibility to oncogenesis.

邻苯二甲酸盐是一种用作增塑剂以增加塑料柔韧性的化合物，被认为是内分泌干扰物。一些研究表明，前列腺癌（PCa）的起源可能与胚胎-胎儿发育过程中的紊乱有关。先前的数据显示，围产期暴露于本文使用的相同邻苯二甲酸盐混合物（PM）会增加老年大鼠前列腺腺癌的发病率。在我们早期工作的基础上，本研究确定了大鼠在妊娠期和哺乳期暴露于PM时前列腺蛋白质组中的蛋白质改变，重点研究了人类分泌组中的蛋白质及其与PCa的相关性。方法将妊娠SD大鼠分为3组，从妊娠第10天（GD）至产后第21天（PND）给药。在PND22上，后代前列腺中差异丰富的蛋白质与人类预测的分泌蛋白质进行了比较。然后，在组间比较所选蛋白质的丰度并进行富集。最后，得到了蛋白-蛋白相互作用网络。将所得数据与PCa数据进行交叉比对，并通过RT-qPCR和Western blot对部分靶点进行验证。结果产前暴露于PM会影响内质网，减少某些蛋白质折叠和分泌的关键蛋白的数量，损害对前列腺正常发育重要的几种蛋白质的分泌。此外，计算机分析显示，大鼠蛋白质组中的几种蛋白质在PCa患者中也发生了改变。结论早期暴露于邻苯二甲酸盐可调节蛋白质分泌，形成损害组织发育和增加肿瘤易感性的微环境。

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引用次数: 0

Uterus Transplantation: State of the Art in and Arrent Status in Mexico 子宫移植：墨西哥的技术现状和现状

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-07 DOI: 10.1016/j.arcmed.2025.103280

Luis Eduardo Magdaleno-Marquez , Sonny John Stetson , Aldo Loza Mapomé , Julio César Del Hierro Yepo , Juan Carlos Cantón Romero , Edwin Ramirez , Federico Mendoza Sánchez , Diego Federico Mendoza Medina , Roberto Enrique Díaz González , Martha Isolina García Amador , Luis Arturo Ruvalcaba-Castellon

This study examines uterine transplantation (UTx) in 2024. It focuses on various aspects, such as animal models, clinical outcomes, surgical procedures, patient perspectives, and ethical and legal considerations. The study particularly considers the context of Mexico. We also explore collaborative initiatives and the public health implications of this innovative reproductive advancement technology.

本研究探讨子宫移植（UTx）在2024年。它侧重于各个方面，如动物模型，临床结果，外科手术，病人的观点，以及伦理和法律方面的考虑。这项研究特别考虑了墨西哥的背景。我们还探讨了这种创新的生殖进步技术的合作倡议和公共卫生影响。

引用次数: 0

Response to Comment on: Evaluation of Multimorbidity Burden in Frailty Transitions in Costa Rican Older Adults Using Multistate Markov Models 用多状态马尔可夫模型评价哥斯达黎加老年人衰弱过渡中的多重疾病负担

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-05 DOI: 10.1016/j.arcmed.2025.103299

RAFAEL OGAZ-GONZÁLEZ , QIAN ZOU , LUIS MIGUEL GUTIÉRREZ-ROBLEDO , MALAQUÍAS LÓPEZ-CERVANTES , EVA CORPELEIJN

引用次数: 0

Probiotics for the Management of Liver Cirrhosis and Its Complications 益生菌治疗肝硬化及其并发症

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-09-05 DOI: 10.1016/j.arcmed.2025.103304

Junxiu Chen , Haonan Zhao , Nahum Méndez-Sánchez , Xingshun Qi

Cirrhosis is the terminal stage of various chronic liver diseases, and its decompensated stage is mainly characterized by serious complications, such as hepatic encephalopathy, ascites, spontaneous bacterial peritonitis, and gastrointestinal bleeding. Gut microbial dysbiosis is prevalent in patients with cirrhosis. Considering the bidirectional regulation of the gut-liver axis, dysbiosis is closely related to the development and progression of liver cirrhosis. Probiotics, which modulate the gut microbiome, have received significant attention for managing cirrhosis and its complications. Through a review of relevant literature, we have provided a comprehensive summary of the potential efficacy of probiotics in treating cirrhosis and its complications, providing new insights into targeting the gut microbiome.

肝硬化是各种慢性肝病的终末阶段，其失代偿期主要表现为严重的并发症，如肝性脑病、腹水、自发性细菌性腹膜炎、胃肠道出血等。肝硬化患者普遍存在肠道微生物失调。考虑到肠肝轴的双向调节，生态失调与肝硬化的发生发展密切相关。调节肠道微生物群的益生菌在治疗肝硬化及其并发症方面受到了极大的关注。通过对相关文献的回顾，我们全面总结了益生菌治疗肝硬化及其并发症的潜在疗效，为靶向肠道微生物群提供了新的见解。

引用次数: 0