Annales pharmaceutiques francaises最新文献

{"title":"Protective effect of Enicostemma axillare - Swertiamarin on oxidative stress against nicotine-induced liver damage in SD rats","authors":"","doi":"10.1016/j.pharma.2024.03.009","DOIUrl":"10.1016/j.pharma.2024.03.009","url":null,"abstract":"<div><h3>Objective</h3><p>The current investigation was aimed to determine the hepatoprotective benefits of Swertiamarin (ST) administration against nicotine-induced hepatotoxicity in SD rats.</p></div><div><h3>Material and methods</h3><p>A total of 48 adult male SD rats were allocated into six groups using a fully randomised approach. As a control, group I was given oral (PO) normal saline. For 65 days, the animals in groups II, III, IV, V and VI received 2.5<!--> <!-->mg/kg/day of nicotine intraperitoneally (IP), 100<!--> <!-->mg/kg/day of ST orally (PO), 200<!--> <!-->mg/kg/day of ST orally (PO), 2.5<!--> <!-->mg/kg/day of nicotine (IP)<!--> <!-->+<!--> <!-->100<!--> <!-->mg/kg/day of ST (PO), and 2.5<!--> <!-->mg/kg/day of nicotine (IP)<!--> <!-->+<!--> <!-->200<!--> <!-->mg/kg/day of ST (PO), respectively. Animals were killed on 66<sup>th</sup>day, liver tissue was removed and used for histopathological analysis as well as biochemical testing (oxidative stress parameters and liver function enzymes).</p></div><div><h3>Results</h3><p>When compared to control animals, the animals in group II showed a substantial rise in their aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels (<em>P</em> <!-->˂<!--> <!-->0.001). Furthermore, compared to control animals, these animals displayed enhanced hepatic oxidative stress as indicated by significantly higher Malondialdehyde (MDA) levels (<em>P</em> <!-->˂<!--> <!-->0.001) and lower levels of Catalase (CAT), Glutathione (GSH), Glutathione peroxidase (GSH-Px) and Superoxide dismutase (SOD) (<em>P</em> <!-->˂<!--> <!-->0.001). Further, more histological anomalies were seen in the liver of nicotine-treated rats compared to control rats, including significant vacuolization, poor tissue architecture, the growth of pycnotic nuclei, and dilated sinusoids. Contrary to nicotine-treated rats, the co-administration of ST and nicotine was observed to prevent the abnormalities caused by nicotine (groups V and VI).</p></div><div><h3>Conclusion</h3><p>The results of the current study show that nicotine can seriously harm liver tissue and that swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind swertiamarin protective impact against nicotine-induced hepatotoxicity.</p></div><div><h3>Objectif</h3><p>La présente enquête visait à déterminer les bénéfices hépatoprotecteurs de l’administration de Swertiamarine (ST) contre l’hépatotoxicité induite par la nicotine chez les rats SD.</p></div><div><h3>Matériel et méthodes</h3><p>Au total, 48 rats SD mâles adultes ont été répartis en six groupes en utilisant une approche entièrement randomisée. À titre de contrôle, le groupe I a reçu une solution saline normale par voie orale (PO). Pendant 65<!--> <!-->jours, les animaux des groupes II, III, IV, V et VI ont reçu 2,5<!--> <!-->mg/kg/j de nicotine par voie intrapéritonéale (IP), 100<!--> <!-->mg/kg/j de","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 792-799"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of quetiapine fumarate loaded polyethylene glycol decorated graphene oxide nanosheets: In vitro-ex vivo characterization","authors":"","doi":"10.1016/j.pharma.2024.04.009","DOIUrl":"10.1016/j.pharma.2024.04.009","url":null,"abstract":"<div><p><span><span>Quetiapine Fumarate (QF) is an atypical antipsychotic with poor oral bioavailability (9%) due to its low permeability and pH-dependent solubility. Therefore, this study aims to design QF-loaded polyethylene glycol (PEG) functionalized </span>graphene oxide<span> nanosheets (GON) for nasal delivery of QF. In brief, GO was synthesized using a modified Hummers process, followed by ultra-sonication to produce GON. Subsequently, PEG-functionalized GON was prepared using carbodiimide chemistry (PEG-GON). QF was then decorated onto the cage of PEG-GON using the π–π stacking phenomenon (QF@PEG-GON). The QF@PEG-GON nanocomposite underwent several spectral characterizations, </span></span><em>in vitro</em> drug release, mucoadhesion study, <em>ex vivo</em> diffusion study, etc. The surface morphology of QF@PEG-GON nanocomposite validates the cracked nature of the nanocomposite, whereas the diffractograms and thermogram of nanocomposite confirm the conversion of QF into an amorphous form with uniform distribution in PEG-GON. Moreover, an <em>ex vivo</em> study of PEG-GON demonstrates superior mucoadhesion capacity due to its surface functional groups and hydrophilicity. The percent drug loading content and percent entrapment efficiency of the nanocomposite were found to be 9.2<!--> <!-->±<!--> <!-->0.62% and 92.3<!--> <!-->±<!--> <!-->1.02%, respectively. The developed nanocomposite exhibited 43.82<!--> <!-->±<!--> <!-->1.65% drug release within 24<!--> <!-->h, with the Korsemeyer-Peppas model providing the best-fit release kinetics (<em>R</em><sup>2</sup>: 0.8614). Here, the interlayer spacing of PEG-GON prevented prompt diffusion of the buffer, leading to a delayed release pattern. In conclusion, the anticipated QF@PEG-GON nanocomposite shows promise as a nanocarrier platform for nasal delivery of QF.</p></div><div><p>Le fumarate de quétiapine (QF) est un antipsychotique atypique avec une faible biodisponibilité orale (9 %) en raison de sa faible perméabilité et de sa solubilité dépendante du pH. Par conséquent, cette étude vise à concevoir des nanofeuilles d’oxyde de graphène (GON) fonctionnalisées en polyéthylène glycol (PEG) chargées de QF pour l’administration nasale de QF. En bref, GO a été synthétisé à l’aide d’un procédé Hummers modifié, suivi d’une ultra-sonication pour produire du GON. Par la suite, du GON fonctionnalisé par PEG a été préparé en utilisant la chimie du carbodiimide (PEG-GON). QF a ensuite été décoré sur la cage de PEG-GON en utilisant le phénomène d’empilement π–π (QF@PEG-GON). Le nanocomposite QF@PEG-GON a subi plusieurs caractérisations spectrales, libération de médicaments in vitro, étude de mucoadhésion, étude de diffusion ex vivo, etc. La morphologie de surface du nanocomposite QF@PEG-GON valide la nature fissurée du nanocomposite, alors que les diffractogrammes et le thermogramme de nanocomposite confirment la conversion du QF en une forme amorphe à distribution uniforme dans le PEG-GON. De plus, une étud","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 848-864"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV rapid tests immunological internal control can be misleading","authors":"","doi":"10.1016/j.pharma.2024.05.009","DOIUrl":"10.1016/j.pharma.2024.05.009","url":null,"abstract":"","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 765-770"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Base de données Enthalpies : évidence et théorie appliquée à la pratique en stérilisation","authors":"","doi":"10.1016/j.pharma.2024.04.002","DOIUrl":"10.1016/j.pharma.2024.04.002","url":null,"abstract":"<div><h3>Objectifs</h3><p>Afin de partager leurs connaissances, les responsables d’unités de stérilisation publient les résultats de leurs travaux dans des revues ou lors de congrès scientifiques. Enthalpies a pour objectif de répertorier l’ensemble de ces travaux dans une base de données unique. Le travail présenté décrit la construction de cette base et l’évaluation de la faisabilité de sa mise en place pour l’étape du lavage.</p></div><div><h3>Méthodes</h3><p>La première étape a consisté à réaliser une revue de la littérature. Seuls les articles publiés sur 10<!--> <!-->ans (2013–2023) en lien avec l’étape de lavage ont été inclus. Ensuite, chaque publication a été catégorisée, codée, gradée et résumée par un binôme pharmacien-interne. L’ensemble de ces données a été colligé dans un tableur Excel® puis à partir de la catégorisation des données, une arborescence a été créée permettant d’appréhender l’interface entre l’utilisateur et la plateforme devant héberger Enthalpies.</p></div><div><h3>Résultats</h3><p>Quatre-vingt et une publications ont été identifiées. Celles-ci ont été catégorisées en 6 thèmes et 27 sous-thèmes. Pour chaque publication, une grille de lecture a été rédigée. Genially®, plateforme en ligne, a été choisi pour héberger notre base de données.</p></div><div><h3>Conclusion</h3><p>Enthalpies n’a pas été conçu pour émettre des recommandations de bonne pratique. Cependant, cet outil permet en colligeant les données scientifiques publiées d’aider à la prise de décision. Il représente une solution innovante pour mettre à disposition une revue de la littérature dans le domaine de la stérilisation hospitalière.</p></div><div><h3>Objectives</h3><p>In order to share their knowledge, sterilization unit managers publish the results of their work in journals or at scientific conferences. The aim of Enthalpies is to list all such work in a single database. The work presented describes the construction of this database and the assessment of its feasibility for the washing step.</p></div><div><h3>Methods</h3><p>The first step was to carry out a literature review. Only articles published over 10<!--> <!-->years (2013–2023) in connection with the ten-year washing stage were included. Then, each publication was categorized, coded, graded and summarized by a pharmacist-internal pair. All this data was collated in an Excel® spreadsheet, and from the data categorization a tree structure was created, enabling the interface between the user and the platform hosting Enthalpies to be understood.</p></div><div><h3>Results</h3><p>Eighty-one publications were identified. These were categorized into 6 themes and 27 sub-themes. A reading grid was drawn up for each publication. Genially®, an online platform, was chosen to host our database.</p></div><div><h3>Conclusion</h3><p>Enthalpies was not designed to issue recommendations for best practice. However, by collating published scientific data, this tool can be used to assist decision-making. It represents","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 916-923"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covid-19 psychological distress: Analysis of antipsychotic drugs’ use in an Italian population sample","authors":"","doi":"10.1016/j.pharma.2024.04.007","DOIUrl":"10.1016/j.pharma.2024.04.007","url":null,"abstract":"<div><h3>Background</h3><p>The current pandemic, in addition to putting a strain on healthcare systems and global economies, has exacerbated psychiatric problems and undermined the mental health of many individuals. In an Italian cohort, this phenomenon has been assessed through a retrospective study aimed at evaluating the consumption and costs of antipsychotic drugs between 2020 and 2022.</p></div><div><h3>Methods</h3><p>All dispensations made in local pharmacies accessible to the public have been extracted from a database called ‘Sistema Tessera Sanitaria’, which covers a population of approximately one million people residents in the ASL Napoli 3 Sud. Consumption data expressed in defined daily dose (DDD) and expenditure data expressed in Euro have been extrapolated.</p></div><div><h3>Results</h3><p>The results in the years 2020–2021 were relatively consistent, with consumption and expenditure decreasing slightly from 2020 to 2021. In 2022, the results showed a decrease in consumption and expenditure (2,706,951.07 DDD and €1,700,897.47) representing the reduced accessibility of patients to the healthcare facilities due to the pandemic. However, it should be noted that the antipsychotic drug aripiprazole showed an upward trend, registering an increase in consumption.</p></div><div><h3>Conclusion</h3><p>Despite expectations of increased consumption of antipsychotic medications, real-world evidence indicated a different phenomenon, with the pandemic seemingly not affecting the consumption of these drugs. The difficulty in accessing care and medical appointments has probably influenced this data, masking the therapeutic needs of citizens. It will be necessary to assess in the coming years, as normal clinical activity resumes, whether there will be a growing consumption of these medications, which represent one of the main expenditure categories for the National Healthcare System.</p></div><div><h3>Contexte</h3><p>La pandémie actuelle, en plus de mettre à rude épreuve les systèmes de santé et les économies mondiales, a exacerbé les problèmes psychiatriques et miné la santé mentale de nombreux individus. Il est bien connu que les événements épidémiques, en particulier les périodes de confinement, augmentent le risque de développer des troubles anxieux, des dépressions et des comportements agressifs.</p></div><div><h3>Méthodes</h3><p>Dans une cohorte italienne, ce phénomène a été évalué par le biais d’une étude rétrospective visant à évaluer la consommation et les coûts des médicaments antipsychotiques pendant et après la pandémie de Covid-19 dans les années 2020–2022. Toutes les ordonnances délivrées dans les pharmacies locales accessibles au public ont été extraites d’une base de données appelée Health Card System, couvrant une population d’environ un million de personnes.</p></div><div><h3>Résultats</h3><p>Les résultats pour les années 2020 à 2021 sont relativement cohérents, la consommation et les dépenses ayant légèrement diminué entre 2020 et ","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 840-847"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic and lipid control in patients with diabetes at time of myocardial infarction","authors":"","doi":"10.1016/j.pharma.2024.04.010","DOIUrl":"10.1016/j.pharma.2024.04.010","url":null,"abstract":"<div><h3>Objective</h3><p>Cardiovascular risk is increased in patients with diabetes. Little is known about glycemic and lipid control in patients with diabetes. We aimed to assess glycemic and lipid controls in patients with diabetes at time of their myocardial infarction.</p></div><div><h3>Method</h3><p>All known patients with type 2 diabetes consecutively admitted for a myocardial infarction in our coronary care unit between March 1<sup>st</sup> and December 31<sup>st</sup>, 2021 were included in this retrospective study. Glycemic and lipid control was assessed through individualized target of glycated haemoglobin (HbA<sub>1c</sub>) and low-density lipoprotein cholesterol (LDL-c), respectively. At admission, the comprehensive list of chronic medications was obtained through medication reconciliation.</p></div><div><h3>Results</h3><p>This study included 112 patients with a median age of 72 years. Most of patients had an individualized target of HbA<sub>1c</sub> and LDL-c of 7.0% (67%) and 0.55<!--> <!-->g/L (96%), respectively. The rate of uncontrolled patients for HbA<sub>1c</sub> and LDL-c and both was 46%, 90%, and 42% respectively. The rate of patients with non-optimal glucose- and lipid-lowering medications in uncontrolled patients was 63% and 87%, respectively. The rate of inappropriate glucose- and lipid-lowering medications was 73% and 91%, respectively.</p></div><div><h3>Conclusion</h3><p>We highlighted the poor glycemic and lipid control in high-risk CV patients. There is an urgent need to develop multidisciplinary approaches to optimize CV risk factors control to reduce myocardial infarction and strokes.</p></div><div><h3>Objectif</h3><p>Les patients diabétiques présentent un haut risqué cardiovasculaire. Peu de données existent sur le contrôle glycémique et lipidique des patients diabétiques en vie réelle. Notre objectif était d’évaluer le contrôle glycémique et lipidique des patients diabétiques au moment de leu infarctus du myocarde.</p></div><div><h3>Méthode</h3><p>Tous les patients diabétiques connus admis dans notre unité de soins intensifs de cardiologie pour un infarctus du myocarde entre mars et décembre 2021 ont été inclus dans notre analyse rétrospective. Le contrôle glycémique et lipidique a été évalué à l’aide des valeurs cibles individualisées d’hémoglobine glyquée (HbA<sub>1c</sub>) et du cholestérol lipoprotéine de faible densité (LDL-c). À l’admission, un bilan médicamenteux optimisé a été effectué par le pharmacien.</p></div><div><h3>Résultats</h3><p>L’étude a inclus 112 patients d’âge médian 72 ans. La plupart des patients avait des valeurs de HbA<sub>1c</sub> et LDL-c cibles de 7,0 % (67 %) et 0,55 g/L (96 %), respectivement. Le taux de patients non contrôlés pour HbA<sub>1c</sub>, LDL-c et les deux était 46 %, 90 % et 42 %, respectivement. Le taux de patients avec un traitement antidiabétique et hypolipémiant non optimal était 63 % et 87 %, respectivement. Le taux de médicaments antidiabétiques et hypolipémiants ","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 865-872"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of mucoadhesive microspheres for intranasal delivery of fluconazole as an alternative treatment of cryptococcal meningitis infection in patients with acquired immunodeficiency","authors":"","doi":"10.1016/j.pharma.2024.04.001","DOIUrl":"10.1016/j.pharma.2024.04.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Cryptococcal meningitis is a deadly disease with few treatment options. Its incidence is still high and closely linked to the HIV/AIDS epidemic. This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route.</p></div><div><h3>Method</h3><p>Microspheres of mucoadhesive fluconazole formulation variables such as different amounts of drug concentration and polymer concentration were prepared by a simple emulsion-crosslinking method. The prepared microspheres’ surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro muco-adhesion, and in-vitro drug release.</p></div><div><h3>Results</h3><p>The results showed that formula 1 is the optimal mucoadhesive microsphere preparation, with a particle size of 56.375<!--> <!-->m, a spherical surface shape, an entrapment efficiency of 99.96%, and a greater mucoadhesive capability during 6-hour evaluation. Furthermore, wash-off examination revealed that the mucoadhesive ability of this delivery system has a long duration and may release the active material at the right time.</p></div><div><h3>Conclusion</h3><p>The result of the researches suggesting that the formulation of mucoadhesive microspheres of fluconazole could be used to treat cryptococcal meningitis infection in HIV/AIDS patients.</p></div><div><h3>Introduction</h3><p>La méningite à cryptocoque est une maladie mortelle avec peu d’options de traitement. Son incidence est encore élevée et étroitement liée à l’épidémie de VIH/sida. Cette étude visait à développer un système d’administration de microsphère muco-adhésif pour le fluconazole par voie intranasale.</p></div><div><h3>Méthode</h3><p>Des microsphères de variables de formulation de fluconazole mucoadhesives telles que différentes quantités de concentration de médicament et de concentration de polymère ont été préparées par une méthode simple de réticulation d’émulsion. La surface des microsphères préparées a été caractérisée par SEM (microscopie électronique à balayage) et évaluée pour la taille des particules, l’efficacité du piégeage, le rendement de la production, l’étude spectroscopique infrarouge, la muco-adhésion in vitro et la libération de médicaments in vitro.</p></div><div><h3>Résultats</h3><p>Les résultats ont montré que la formule (1) est la préparation optimale de la microsphère muco-adhésive, avec une taille de particule de 56,375<!--> <!-->m, une forme de surface sphérique, une efficacité de piégeage de 99,96 % et une plus grande capacité de muco-adhésive pendant 6<!--> <!-->h d’évaluation. De plus, l’examen de lavage a révélé que la capacité muco-adhésive de ce système d’administration a une longue durée et peut libérer le matériau actif au bon moment.</p></div><div><h3>Conclusion</h3><p>Le résultat des recherches suggère que la formulation de microsphères muco-adhésives du fluconazole pour","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 813-821"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary cytomegalovirus excretion: The unresolved issues","authors":"","doi":"10.1016/j.pharma.2024.03.004","DOIUrl":"10.1016/j.pharma.2024.03.004","url":null,"abstract":"<div><p>Cytomegalovirus (CMV) excretion in urine is frequently observed in clinical practice. However, the specific circumstances and pathophysiological mechanisms underlying this shedding remain largely unknown. Here, we address some of the key questions regarding urinary CMV excretion, focusing on new hypotheses raised by recent advances in the field. Cellular origins of CMV shedding, clinical contexts of occurrence, systemic spread of the virus <em>versus</em> compartmentalization in the urinary tract, and clinical impact are successively discussed.</p></div><div><p>Le cytomégalovirus (CMV) est fréquemment détecté dans l’urine mais les circonstances cliniques et les mécanismes physiopathologiques qui sous-tendent cette virurie restent mal compris. Dans cette revue, nous cherchons à répondre aux principales questions soulevées par cette excrétion urinaire de CMV, en appréhendant successivement: l’origine cellulaire de l’excrétion virale au sein de l’arbre urinaire, le contexte clinique sous-jacent, la distinction entre diffusion systémique du virus et compartimentation et l’impact clinique de ces viruries à CMV.</p></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"82 5","pages":"Pages 755-761"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140139838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validated green and white RP-HPLC method for the estimation of Zolmitriptan in marketed dosage form.","authors":"Channabasavaiah Naveenaradhya, Veeresh Prabhakar Veerapur, Ranganatha Puttaraju, Kodigenahalli Balarajagupta Ajaykumar, DeviReddy Prashanthi, Varsha D Savanth, Mathud Shivamurthaiah Chaithanya, Bychapur Siddaiah Gowrishankar","doi":"10.1016/j.pharma.2024.08.010","DOIUrl":"10.1016/j.pharma.2024.08.010","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a rapid, accurate, economical, effective and greenery RP-HPLC method for the determination of Zolmitriptan in tablet dosage form.</p><p><strong>Material and method: </strong>RP-HPLC method was developed using Luna (C₁₈) (4.6×250mm, 5μm) column and Sodium phosphate buffer (pH 4.7): Methanol [75: 25, v/v] was used as mobile phase at a flow rate of 1.0mL/min. The detection was carried out at 227nm. Further, eco-friendliness, productivity and performance of the optimized analytical method were assessed by green and white tools.</p><p><strong>Results: </strong>The retention time of Zolmitriptan was found to be 3.25min with acceptable chromatographic parameters. The optimized RP-HPLC method was more eco-friendly, efficient, throughput and practicable than the reported methods as confirmed by AES, AGREE, GAPI and RGB tools. Further, the proposed analytical method showed all the validation parameters within the acceptance limit of ICH Q₂ R₁ guidelines. The linear regression analysis indicated a good linear response in the 10 to 120μg/mL concentration range with R² of 0.99998. The percentage content and percentage assay of Zolmitriptan in Zomig-5mg tablet was found to be 103.36±0.356% and 97.86±0.693%.</p><p><strong>Conclusion: </strong>The developed and validated method has several advantages compared to the reported HPLC methods and is useful in the systematic analysis of Zolmitriptan in its dosage form.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application progress of nanomaterials in the treatment of prostate cancer.","authors":"Xuewu Wu, Longtu Ma, Yang Zhang, Shuai Liu, Long Cheng, Chengyu You, Zhilong Dong","doi":"10.1016/j.pharma.2024.08.009","DOIUrl":"10.1016/j.pharma.2024.08.009","url":null,"abstract":"<p><p>Prostate cancer is one of the most common malignant tumors in men, which seriously threatens the survival and quality of life of patients. At present, there are serious limitations in the treatment of prostate cancer, such as drug tolerance, drug resistance and easy recurrence. Sonodynamic therapy and chemodynamic therapy are two emerging tumor treatment methods, which activate specific drugs or sonosensitizers through sound waves or chemicals to produce reactive oxygen species and kill tumor cells. Nanomaterials are a kind of nanoscale materials with many excellent physical properties such as high targeting, drug release regulation and therapeutic monitoring. Sonodynamic therapy and chemodynamic therapy combined with the application of nanomaterials can improve the therapeutic effect of prostate cancer, reduce side effects and enhance tumor immune response. This article reviews the application progress of nanomaterials in the treatment of prostate cancer, especially the mechanism, advantages and challenges of nanomaterials in sonodynamic therapy and chemodynamic therapy, which provides new ideas and prospects for research in this field.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}