Pub Date : 2020-01-01DOI: 10.35841/2249-622X.72.EDITORIAL
M. Luisetto
We are happy to the present the Volume 10 issue 73 of the Asian Journal of Biomedical and Pharmaceutical Sciences wherein we have unconfined excellence and prototypical works inside all the applicable chastisements in biomedical and pharmaceutical sciences. The articles in this Issue deliberate numerous characteristics of the Present tendencies in Asian Journal of Biomedical and Pharmaceutical Sciences. Asian Journal of Biomedical and Pharmaceutical Sciences is helmed with specialists everywhere the world as Editors. Asian Journal of Biomedical and Pharmaceutical Sciences has established and stimulated investigation into the relatives among biology and medical sciences. Our journal privileges high standing in considerate and fast-tracking numerous articles in biomedical sciences and several other related topics as well. Making an allowance for the position of human healthiness in the present consequence and numerous alternative medicinal and scientific issues related with it, the major courtesy in the direction of biomedical and pharmaceutical sciences all over the world is of excessive consequence. Thus, by declaring the obligation of a mutual and supplemented evidence division stage, Asian journal of biomedical and pharmaceutical sciences has been allocation persons with Excellence data in all field of Biology and Medical Sciences Widely read by theoretical and applied scholars, physicians, clinicians, faculty and experts, the journal prints articles of a applied or theoretical nature that effort to development our sympathetic of the Biomedical and Pharmaceutical Sciences.
{"title":"Opinion on biomedical and pharmaceutical sciences.","authors":"M. Luisetto","doi":"10.35841/2249-622X.72.EDITORIAL","DOIUrl":"https://doi.org/10.35841/2249-622X.72.EDITORIAL","url":null,"abstract":"We are happy to the present the Volume 10 issue 73 of the Asian Journal of Biomedical and Pharmaceutical Sciences wherein we have unconfined excellence and prototypical works inside all the applicable chastisements in biomedical and pharmaceutical sciences. The articles in this Issue deliberate numerous characteristics of the Present tendencies in Asian Journal of Biomedical and Pharmaceutical Sciences. Asian Journal of Biomedical and Pharmaceutical Sciences is helmed with specialists everywhere the world as Editors. Asian Journal of Biomedical and Pharmaceutical Sciences has established and stimulated investigation into the relatives among biology and medical sciences. Our journal privileges high standing in considerate and fast-tracking numerous articles in biomedical sciences and several other related topics as well. Making an allowance for the position of human healthiness in the present consequence and numerous alternative medicinal and scientific issues related with it, the major courtesy in the direction of biomedical and pharmaceutical sciences all over the world is of excessive consequence. Thus, by declaring the obligation of a mutual and supplemented evidence division stage, Asian journal of biomedical and pharmaceutical sciences has been allocation persons with Excellence data in all field of Biology and Medical Sciences Widely read by theoretical and applied scholars, physicians, clinicians, faculty and experts, the journal prints articles of a applied or theoretical nature that effort to development our sympathetic of the Biomedical and Pharmaceutical Sciences.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"31 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81499604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.71.15986
Manigundan Kaari, Jerrine Joseph, Sivarajan Anbalman, V. Angamuthu, A. Sreenivasan, G. Venugopal, R. Manikkam, Balagurunathan Ramasamy, WilsonAruni
A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus. Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage (LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68
{"title":"A multifunctional Streptomyces maritimus SACC-152 isolated from Andaman and Nicobar Islands, India.","authors":"Manigundan Kaari, Jerrine Joseph, Sivarajan Anbalman, V. Angamuthu, A. Sreenivasan, G. Venugopal, R. Manikkam, Balagurunathan Ramasamy, WilsonAruni","doi":"10.35841/2249-622X.71.15986","DOIUrl":"https://doi.org/10.35841/2249-622X.71.15986","url":null,"abstract":"A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus. Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage (LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1","pages":"10-19"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79948494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.70.20
J. Amiral
A subset of patients affected by the recent Covid-19 pandemic develop critical or fatal clinical outcomes, which causes are not always fully understood. A delayed exaggerated immune and inflammatory response develops, inducing severe clinical complications which are associated with induced hemostasis activation, thrombosis, disseminated intra vascular coagulation, vasculitis, and multiorgan failure. This SARS-Cov-2 infection induces a dysregulation of the Renin Angiotensin Aldosterone system by shedding the protective cell surface receptor ACE2, and this can be a major contributor to disease evolution. In addition, the viral cell entry mechanism requires the formation of an intimate and high affinity binding complex between virus spike protein RBD and ACE2. An alloimmune response could then develop with generation of autoantibodies to ACE2, which could be responsible for an acute autoimmune response, and for the deleterious exacerbated inflammatory reaction. This report discusses the rationale for that hypothesis and describes how it could impact the disease course.
{"title":"SARS-Cov-2 infection as an ideal context for inducing autoantibodies to ACE2: Autoimmune clinical complications as possible causes for disease presentation, severity, and duration.","authors":"J. Amiral","doi":"10.35841/2249-622X.70.20","DOIUrl":"https://doi.org/10.35841/2249-622X.70.20","url":null,"abstract":"A subset of patients affected by the recent Covid-19 pandemic develop critical or fatal clinical outcomes, which causes are not always fully understood. A delayed exaggerated immune and inflammatory response develops, inducing severe clinical complications which are associated with induced hemostasis activation, thrombosis, disseminated intra vascular coagulation, vasculitis, and multiorgan failure. This SARS-Cov-2 infection induces a dysregulation of the Renin Angiotensin Aldosterone system by shedding the protective cell surface receptor ACE2, and this can be a major contributor to disease evolution. In addition, the viral cell entry mechanism requires the formation of an intimate and high affinity binding complex between virus spike protein RBD and ACE2. An alloimmune response could then develop with generation of autoantibodies to ACE2, which could be responsible for an acute autoimmune response, and for the deleterious exacerbated inflammatory reaction. This report discusses the rationale for that hypothesis and describes how it could impact the disease course.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86179184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.71.16928
Harinderjit Singh, H. Mukhtar
The Citrullus lanatus is commonly known as watermelon belonging to family Cucurbitaceae. Traditionally, the plant has been used as anticancer, antibacterial, demulcent and diuretic. The review of literature available online suggested that geographical variation wise quantitative determination of total phenols and flavonoids in plant material has not been carried out. Thus, it was planned to quantify total phenols and flavonoids content in this plant collected from different geographical places of India such as Rajasthan, Punjab and Haryana. The various extract and fractions were prepared separately using Soxhletion and reflux techniques, respectively, as per standardized procedure. The extracts/fractions were subjected to preliminary phytochemical testes. The various crude extracts/fractions were subjected to quantitative determination of total phenols and flavonoids content using well established procedures known as FolinCiocalteu’s assay and aluminium chloride assay, respectively. The ethyl acetate fractions of Citrullus lanatus fruits obtained from different geographical sites contained higher content of total phenols and flavonoids than their respective acetone extract and ethanol extract. Amongst various extracts/fractions of tested samples of plant, Rajasthan sample contained higher content of total phenols and flavonoids followed by Punjab and Haryana samples. As preliminary phytochemical screening of ethanol and its ethyl acetate fractions showed presence of phenolic and flavonoids constituents. Thus, it can be also concluded that these compounds may be responsible for scientifically reported pharmacological profile of this plant.
{"title":"In vitro parameters used in evaluation of flavonoids and phenols contents of Citrullus species fruits.","authors":"Harinderjit Singh, H. Mukhtar","doi":"10.35841/2249-622X.71.16928","DOIUrl":"https://doi.org/10.35841/2249-622X.71.16928","url":null,"abstract":"The Citrullus lanatus is commonly known as watermelon belonging to family Cucurbitaceae. Traditionally, the plant has been used as anticancer, antibacterial, demulcent and diuretic. The review of literature available online suggested that geographical variation wise quantitative determination of total phenols and flavonoids in plant material has not been carried out. Thus, it was planned to quantify total phenols and flavonoids content in this plant collected from different geographical places of India such as Rajasthan, Punjab and Haryana. The various extract and fractions were prepared separately using Soxhletion and reflux techniques, respectively, as per standardized procedure. The extracts/fractions were subjected to preliminary phytochemical testes. The various crude extracts/fractions were subjected to quantitative determination of total phenols and flavonoids content using well established procedures known as FolinCiocalteu’s assay and aluminium chloride assay, respectively. The ethyl acetate fractions of Citrullus lanatus fruits obtained from different geographical sites contained higher content of total phenols and flavonoids than their respective acetone extract and ethanol extract. Amongst various extracts/fractions of tested samples of plant, Rajasthan sample contained higher content of total phenols and flavonoids followed by Punjab and Haryana samples. As preliminary phytochemical screening of ethanol and its ethyl acetate fractions showed presence of phenolic and flavonoids constituents. Thus, it can be also concluded that these compounds may be responsible for scientifically reported pharmacological profile of this plant.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"31 1","pages":"20-22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90552709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.69.4552
Arianna Yglesias-Rivera, Ana Mary Sánchez-Mamposo, Alexis DÃaz-GarcÃa, Hermis RodrÃguezSánchez
Introduction: The endemic scorpion venom of Cuba, Rhopalurus junceus (R. junceus), decreases the viability of tumor cells of epithelial origin and has no cytotoxic effect on normal cells. However, its antineoplastic effect on murine colon tumor cells and the type of pharmacological interaction of its combination with conventional chemotherapeutic agents used in the clinic for the treatment of colon cancer have not been evaluated. Objective: To determine the potentiality of the R. junceus scorpion venom to increase the cytotoxic effect of conventional cytostatics on colon tumor cells. Materials and methods: CT26 murine colon tumor cells were treated simultaneously at a constant rate of concentrations equal to or lower than the mean inhibitory concentration (IC50) of the venom of the scorpion R. junceus and the cytostatics: doxorubicin (DOX), cisplatin (CDPP) and paclitaxel (PTX), respectively. Cell viability was determined by the MTT assay, after 72 hours of incubation and the determination of apoptotic cell formation was determined by DAPI staining after 24 hours of combination with ½ of the IC50. The combination and dose reduction rate was determined by the Compusyn software. Results: The combination of venom with CPDX, PTX, and DOX, paclitaxel and doxorubicin significantly reduced the viability of the CT26 tumor line, compared to individual treatments. The type of drug interaction of said combination was synergistic at high concentrations. Individual treatment with ½ of the IC50 of R. junceus scorpion venom or with conventional cytostatics and the combination of each cytostatic with the venom induced morphological changes characteristic of cell death by apoptosis. Conclusion: R. junceus scorpion venom in combination with CDDP, PTX, and DOX paclitaxel, doxorubicin and cisplatin increases the cytotoxicity of these chemotherapeutic agents on colon tumor cells.
{"title":"Synergism of the combination of Rhopalurus junceus scorpion venom with conventional cytostatics in the ct26 tumor cell line.","authors":"Arianna Yglesias-Rivera, Ana Mary Sánchez-Mamposo, Alexis DÃaz-GarcÃa, Hermis RodrÃguezSánchez","doi":"10.35841/2249-622X.69.4552","DOIUrl":"https://doi.org/10.35841/2249-622X.69.4552","url":null,"abstract":"Introduction: The endemic scorpion venom of Cuba, Rhopalurus junceus (R. junceus), decreases the viability of tumor cells of epithelial origin and has no cytotoxic effect on normal cells. However, its antineoplastic effect on murine colon tumor cells and the type of pharmacological interaction of its combination with conventional chemotherapeutic agents used in the clinic for the treatment of colon cancer have not been evaluated. Objective: To determine the potentiality of the R. junceus scorpion venom to increase the cytotoxic effect of conventional cytostatics on colon tumor cells. Materials and methods: CT26 murine colon tumor cells were treated simultaneously at a constant rate of concentrations equal to or lower than the mean inhibitory concentration (IC50) of the venom of the scorpion R. junceus and the cytostatics: doxorubicin (DOX), cisplatin (CDPP) and paclitaxel (PTX), respectively. Cell viability was determined by the MTT assay, after 72 hours of incubation and the determination of apoptotic cell formation was determined by DAPI staining after 24 hours of combination with ½ of the IC50. The combination and dose reduction rate was determined by the Compusyn software. Results: The combination of venom with CPDX, PTX, and DOX, paclitaxel and doxorubicin significantly reduced the viability of the CT26 tumor line, compared to individual treatments. The type of drug interaction of said combination was synergistic at high concentrations. Individual treatment with ½ of the IC50 of R. junceus scorpion venom or with conventional cytostatics and the combination of each cytostatic with the venom induced morphological changes characteristic of cell death by apoptosis. Conclusion: R. junceus scorpion venom in combination with CDDP, PTX, and DOX paclitaxel, doxorubicin and cisplatin increases the cytotoxicity of these chemotherapeutic agents on colon tumor cells.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"98 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78210116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622x.70.13713
Thakor Shivani R, Sharma Bhavesh R
Chalcone is a fragrant ketone that frames a focal center for an assortment of significant organic mixes, which are altogether known as chalcones. They have various exercises like antibacterial, antifungal, mitigating and against tumor and so on relying upon the replacement made on them. Chalcones are regular item has a place with Flavonoid family. Chalcones are 1, 3-diphenyl-2-propene-1-one, in which two fragrant rings are connected by a three carbon α, β-unsaturated carbonyl framework. Chalcones and their heterocyclic analogs appreciate a scope of organic exercises, for example, antimicrobial, cancer prevention agent, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and calming exercises which makes these mixes as an extraordinary fascination for examination. Also the bielectrophilic, ketovinyl chain between the two rings is profoundly receptive and goes about as a significant synthetic synthon for building diverse five, six and seven part heterocyclic frameworks containing distinctive hetero molecules like nitrogen, oxygen and sulfur iotas by compressed version with an assortment of binucleophilic reagents.
{"title":"A review: Chemical and biological activity of chalcones with their metal complex","authors":"Thakor Shivani R, Sharma Bhavesh R","doi":"10.35841/2249-622x.70.13713","DOIUrl":"https://doi.org/10.35841/2249-622x.70.13713","url":null,"abstract":"Chalcone is a fragrant ketone that frames a focal center for an assortment of significant organic mixes, which are altogether known as chalcones. They have various exercises like antibacterial, antifungal, mitigating and against tumor and so on relying upon the replacement made on them. Chalcones are regular item has a place with Flavonoid family. Chalcones are 1, 3-diphenyl-2-propene-1-one, in which two fragrant rings are connected by a three carbon α, β-unsaturated carbonyl framework. Chalcones and their heterocyclic analogs appreciate a scope of organic exercises, for example, antimicrobial, cancer prevention agent, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and calming exercises which makes these mixes as an extraordinary fascination for examination. Also the bielectrophilic, ketovinyl chain between the two rings is profoundly receptive and goes about as a significant synthetic synthon for building diverse five, six and seven part heterocyclic frameworks containing distinctive hetero molecules like nitrogen, oxygen and sulfur iotas by compressed version with an assortment of binucleophilic reagents.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"6 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77515874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.70.10551
M. Gormley
The article published recently in the Lancet Global Health, COVID-19: mitigating the transmission via wastewater plumbing systems [1] is a synthesis of 17 years of study into the spread of disease as a result of defects in the wastewater plumbing system (sanitary system) within buildings, however it the issues associated with this mode of transmission are more appropriately attributed to tall (high-rise) or complex buildings [2].
{"title":"COVID-19: Complexities in understanding transmission pathways through sanitary systems in high-rise buildings.","authors":"M. Gormley","doi":"10.35841/2249-622X.70.10551","DOIUrl":"https://doi.org/10.35841/2249-622X.70.10551","url":null,"abstract":"The article published recently in the Lancet Global Health, COVID-19: mitigating the transmission via wastewater plumbing systems [1] is a synthesis of 17 years of study into the spread of disease as a result of defects in the wastewater plumbing system (sanitary system) within buildings, however it the issues associated with this mode of transmission are more appropriately attributed to tall (high-rise) or complex buildings [2].","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"2 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84281220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622X.72.19503
M. Rizzo, I. Pezone, M. Amicone, E. Riccio, A. Pisani
Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome with a high mortality rate; it is caused by SARS-CoV-2, a new virus of the Coronaviridae family that emerged in Wuhan, Hubei, China, in December 2019 and rapidly spread worldwide until declared by the World Health Organization a global pandemic on March 11th, 2020. The race for an effective drug to prevent or treat SARS-CoV-2 infection is the highest priority among health care providers, government officials, and the pharmaceutical industry. Despite scientific effort, no pharmacological intervention has proven definitively beneficial, and care is primarily supportive.
{"title":"Mini Review: Heparin treatment in COVID-19: Where are we?","authors":"M. Rizzo, I. Pezone, M. Amicone, E. Riccio, A. Pisani","doi":"10.35841/2249-622X.72.19503","DOIUrl":"https://doi.org/10.35841/2249-622X.72.19503","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome with a high mortality rate; it is caused by SARS-CoV-2, a new virus of the Coronaviridae family that emerged in Wuhan, Hubei, China, in December 2019 and rapidly spread worldwide until declared by the World Health Organization a global pandemic on March 11th, 2020. The race for an effective drug to prevent or treat SARS-CoV-2 infection is the highest priority among health care providers, government officials, and the pharmaceutical industry. Despite scientific effort, no pharmacological intervention has proven definitively beneficial, and care is primarily supportive.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"76 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87576907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
?I am going to present you the forthcoming issue for journal. Through this issue, the Editorship of biomedical and pharmaceutical sciences is truthfully thankful for the maintenance providing by the reviewers who loyally agreed out their complete reviews of the papers for this edition. We stimulated high quality articles for review and potential publication in all areas of biology and medical sciences, science and biotechnology. While evidently diverse and diverse in environment, these upcoming articles characterize the present intellectual regarding significant and energetics study parts that assurance additional supposed and investigation effort. The printed articles in journal will help specialists and scholars to approach, evaluate and leading the modern detail conclusions in the co?
{"title":"Present study of Biomedical and Pharmaceutical Sciences.","authors":"K. Fujioka","doi":"10.35841/2249-622X.71.E","DOIUrl":"https://doi.org/10.35841/2249-622X.71.E","url":null,"abstract":"?I am going to present you the forthcoming issue for journal. Through this issue, the Editorship of biomedical and pharmaceutical sciences is truthfully thankful for the maintenance providing by the reviewers who loyally agreed out their complete reviews of the papers for this edition. We stimulated high quality articles for review and potential publication in all areas of biology and medical sciences, science and biotechnology. While evidently diverse and diverse in environment, these upcoming articles characterize the present intellectual regarding significant and energetics study parts that assurance additional supposed and investigation effort. The printed articles in journal will help specialists and scholars to approach, evaluate and leading the modern detail conclusions in the co?","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"13 1","pages":"28-28"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75979094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35841/2249-622x.70.10550
Deshmukh Mt, Mohite Sk
Olanzepine microsphere prepared by external Inotropic gelation technique by using sodium alginate and carbopol 974 P as a polymer and calcium chloride as a cross linking agent. In this formulation combination of sodium alginate and carbopol 974 P used as a polymer that helps to retard the releasing the drug and increases bioavaibility of drug. The Olanzepine microsphere has other characterization is in the term ofdrug content, drug entrapment efficiency, P XRD, Differential Scanning Colorimetry, FTIR , SEM, in vitro drug release and in vivo drug release. The in vitro release pattern of Olanzepine microsphere studied in 900 ml of 0.1 N Hydrochloric acids, using USP dissolution apparatus I. The optimized batch F7 shows greater than 80 % of drug release that is due to using carbopol polymer that helps to retarded the drug release at targeted site over the other formulation. Optimized formulation shows better antidepressant action as compare to pure Olanzepine drug.
以海藻酸钠和卡波醇974p为聚合物，氯化钙为交联剂，采用外肌力凝胶法制备奥氮平微球。在这个配方中，海藻酸钠和卡泊泊974p作为聚合物的组合，有助于延缓药物的释放，提高药物的生物利用度。所制备的奥氮平微球在药物含量、药物包封效率、P - XRD、差示扫描比色、FTIR、SEM、体外释药和体内释药等方面进行了表征。利用USP溶出仪研究了奥氮平微球在900 ml 0.1 N盐酸中的体外释放规律。优化批F7的释药率大于80%，这是由于使用了卡波醇聚合物，有助于延缓药物在目标部位的释放。与纯奥氮平相比，优化后的配方具有更好的抗抑郁作用。
{"title":"Formulation, optimization and characterization of gastro retentive olanzepine microsphere using 32 factorial design.","authors":"Deshmukh Mt, Mohite Sk","doi":"10.35841/2249-622x.70.10550","DOIUrl":"https://doi.org/10.35841/2249-622x.70.10550","url":null,"abstract":"Olanzepine microsphere prepared by external Inotropic gelation technique by using sodium alginate and carbopol 974 P as a polymer and calcium chloride as a cross linking agent. In this formulation combination of sodium alginate and carbopol 974 P used as a polymer that helps to retard the releasing the drug and increases bioavaibility of drug. The Olanzepine microsphere has other characterization is in the term ofdrug content, drug entrapment efficiency, P XRD, Differential Scanning Colorimetry, FTIR , SEM, in vitro drug release and in vivo drug release. The in vitro release pattern of Olanzepine microsphere studied in 900 ml of 0.1 N Hydrochloric acids, using USP dissolution apparatus I. The optimized batch F7 shows greater than 80 % of drug release that is due to using carbopol polymer that helps to retarded the drug release at targeted site over the other formulation. Optimized formulation shows better antidepressant action as compare to pure Olanzepine drug.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81276331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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