Hepatocellular Carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Several risk factors responsible for development of HCC are liver and biliary Cirrhosis, Alcohol consumption, Hepatitis B and C infection, exposure to carcinogenic substance like Aflatoxin and Arsenic, comorbid condition like Obesity and Diabetes etc. In this review we discus about risk factors, screening methods and stages of HCC. Multiple treatment availability such as Radiation therapy, Chemotherapy and Surgical procedures along with newer modalities like Targeted Drug Delivery System, use of nano technology, newer Immunomodulators and Radiofrequency Ablation. Continued improvement in both surgical and nonsurgical approaches has demonstrated significant benefits in overall survival.
{"title":"Hepatocellular Carcinoma: A Review","authors":"Dhandhukiya Manavkumar Kanubhai, Saiyed Musaratafrin Sabirali","doi":"10.52711/2231-5659.2023.00030","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00030","url":null,"abstract":"Hepatocellular Carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Several risk factors responsible for development of HCC are liver and biliary Cirrhosis, Alcohol consumption, Hepatitis B and C infection, exposure to carcinogenic substance like Aflatoxin and Arsenic, comorbid condition like Obesity and Diabetes etc. In this review we discus about risk factors, screening methods and stages of HCC. Multiple treatment availability such as Radiation therapy, Chemotherapy and Surgical procedures along with newer modalities like Targeted Drug Delivery System, use of nano technology, newer Immunomodulators and Radiofrequency Ablation. Continued improvement in both surgical and nonsurgical approaches has demonstrated significant benefits in overall survival.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"405 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79758499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00015
Sudhakar B., Akshaya Karipe, R. Sri. S
A new, simple, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validation of Bilastine and Montelukast in its pure form as well as in combined marketed formulation. Chromatography was carried out on a Phenomenex Luna C18 (4.6mm×250mm) 5µm particle size column using a mixture of Methanol: Phosphate Buffer (pH-4.2) (37:63% v/v) as the mobile phase at a flow rate of 1.0ml/min, thedetection was carried out at 260nm. The retention time of the Bilastine and Montelukast was found to be was 2.133, 3.692±0.02 min respectively. The method was validated according to ICH guidelines for linearity, sensitivity, accuracy, precision, specificity and robustness. The method produce linear responses in the concentration range of 20-60mg/ml of Bilastine and 10-30mg/ml of Montelukast.The inter-day and intra-day precisions were found to be within limits. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
{"title":"Analytical Method Development and Validation for the Simultaneous Estimation of Bilastine and Montelukast by RP-HPLC","authors":"Sudhakar B., Akshaya Karipe, R. Sri. S","doi":"10.52711/2231-5659.2023.00015","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00015","url":null,"abstract":"A new, simple, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validation of Bilastine and Montelukast in its pure form as well as in combined marketed formulation. Chromatography was carried out on a Phenomenex Luna C18 (4.6mm×250mm) 5µm particle size column using a mixture of Methanol: Phosphate Buffer (pH-4.2) (37:63% v/v) as the mobile phase at a flow rate of 1.0ml/min, thedetection was carried out at 260nm. The retention time of the Bilastine and Montelukast was found to be was 2.133, 3.692±0.02 min respectively. The method was validated according to ICH guidelines for linearity, sensitivity, accuracy, precision, specificity and robustness. The method produce linear responses in the concentration range of 20-60mg/ml of Bilastine and 10-30mg/ml of Montelukast.The inter-day and intra-day precisions were found to be within limits. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76959973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00003
K. Nagasree, K. Pallavi, R. Sri. S
Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.
{"title":"Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine","authors":"K. Nagasree, K. Pallavi, R. Sri. S","doi":"10.52711/2231-5659.2023.00003","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00003","url":null,"abstract":"Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81115989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00011
Vaishnavi J. Chaudhari, Dhananjay D. Chaudhari
The profession of pharmacy has undergone enormous changes in recent decades. The function of the pharmacy has expanded to include more health services. However, the extent to which this role is fulfilled can vary. This review aims to describe the range and extent of professional pharmacy services offered in hospital pharmacies in different countries and the barriers associated with inadequate or incomplete implementation of these services.
{"title":"A Short Review on Hospital Pharmacy","authors":"Vaishnavi J. Chaudhari, Dhananjay D. Chaudhari","doi":"10.52711/2231-5659.2023.00011","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00011","url":null,"abstract":"The profession of pharmacy has undergone enormous changes in recent decades. The function of the pharmacy has expanded to include more health services. However, the extent to which this role is fulfilled can vary. This review aims to describe the range and extent of professional pharmacy services offered in hospital pharmacies in different countries and the barriers associated with inadequate or incomplete implementation of these services.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78474660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00012
Mayur M. More, Nilesh K. Nerkar
The review paper conducted on the study about a demonstration of fluidized bed dryer particular application and principle and other processing. Fluidized bed dryer (also called fluid bed dryer) is a kind of equipment used extensively in the pharmaceutical industries to reduce the moisture content of pharmaceutical powder and granules. The wet solids are lifted from the bottom and suspend in a stream of air (fluidized state). Fluidized bed dryer are very well known to yield high heat and mass transfer hence adopted to many pharmaceutical industries drying process particularly product. In this review paper we show the construction, working, and applications or several disadvantages of fluidized bed dryer (FBD).
{"title":"A Review on Fluidized Bed Dryer","authors":"Mayur M. More, Nilesh K. Nerkar","doi":"10.52711/2231-5659.2023.00012","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00012","url":null,"abstract":"The review paper conducted on the study about a demonstration of fluidized bed dryer particular application and principle and other processing. Fluidized bed dryer (also called fluid bed dryer) is a kind of equipment used extensively in the pharmaceutical industries to reduce the moisture content of pharmaceutical powder and granules. The wet solids are lifted from the bottom and suspend in a stream of air (fluidized state). Fluidized bed dryer are very well known to yield high heat and mass transfer hence adopted to many pharmaceutical industries drying process particularly product. In this review paper we show the construction, working, and applications or several disadvantages of fluidized bed dryer (FBD).","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82371899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00014
Dhananjay D. Chaudhari, Mohit R. Koli
Drug regulatory affairs are an important part of the pharmaceutical industry. As usual The pharmaceutical industry is growing very fast, and there is a need Regulatory affairs experts to meet current needs industry for global competition. Drug Regulatory Affairs Specialists are an important link between the pharmaceutical industry And regulatory agencies around the world. Drug product approval Should be an important step to ensure that the process is safe and effective Drug. Central Narcotics Control Organization (CDSCO), India Decided to adopt the CTD format for the technical requirements for Registration of medicinal products for human use. Implementation CTD is expected to significantly reduce the time and resources required By industry to prepare applications for global registration. In this article Evolution of Drug Regulatory Issues, Roles and Relationships in the Pharmaceutical Industry to implement CTD guidelines to regulate and improve drug marketing industrial development
{"title":"Drug Regulatory Affairs: Short Review","authors":"Dhananjay D. Chaudhari, Mohit R. Koli","doi":"10.52711/2231-5659.2023.00014","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00014","url":null,"abstract":"Drug regulatory affairs are an important part of the pharmaceutical industry. As usual The pharmaceutical industry is growing very fast, and there is a need Regulatory affairs experts to meet current needs industry for global competition. Drug Regulatory Affairs Specialists are an important link between the pharmaceutical industry And regulatory agencies around the world. Drug product approval Should be an important step to ensure that the process is safe and effective Drug. Central Narcotics Control Organization (CDSCO), India Decided to adopt the CTD format for the technical requirements for Registration of medicinal products for human use. Implementation CTD is expected to significantly reduce the time and resources required By industry to prepare applications for global registration. In this article Evolution of Drug Regulatory Issues, Roles and Relationships in the Pharmaceutical Industry to implement CTD guidelines to regulate and improve drug marketing industrial development","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78388735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00008
Dhananjay D. Chaudhari, Satish D. Mali, Vaishnavi Chaudhari
Targeted drug delivery is an advanced method of delivering drugs to patients in such a targeted order that increases the concentration of the delivered drug only on the body part of interest (organs/tissues/cells), which in turn improves the effectiveness of the treatment while reducing side effects of drug administration. Basically, drug targeting should help the drug molecule to preferentially reach the desired site. The inherent advantage of this technique results in the administration of the required drug with its reduced dose and reduced side effect. This inherent advantage of a targeted drug delivery system is also strongly recognized by research and development in the clinical and pharmaceutical fields as the backbone of therapeutics and diagnostics. Various drug carriers that can be used in this advanced delivery system are soluble polymers, biodegradable microsphere polymers (synthetic and natural), neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles, and immune micelles. The goal of a targeted drug delivery system is to prolong, localize, target, and have a protected drug interaction with the diseased.
{"title":"A Short Review on Recent Approches in Targeted Drug Dilvairy System (TDDS)","authors":"Dhananjay D. Chaudhari, Satish D. Mali, Vaishnavi Chaudhari","doi":"10.52711/2231-5659.2023.00008","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00008","url":null,"abstract":"Targeted drug delivery is an advanced method of delivering drugs to patients in such a targeted order that increases the concentration of the delivered drug only on the body part of interest (organs/tissues/cells), which in turn improves the effectiveness of the treatment while reducing side effects of drug administration. Basically, drug targeting should help the drug molecule to preferentially reach the desired site. The inherent advantage of this technique results in the administration of the required drug with its reduced dose and reduced side effect. This inherent advantage of a targeted drug delivery system is also strongly recognized by research and development in the clinical and pharmaceutical fields as the backbone of therapeutics and diagnostics. Various drug carriers that can be used in this advanced delivery system are soluble polymers, biodegradable microsphere polymers (synthetic and natural), neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles, and immune micelles. The goal of a targeted drug delivery system is to prolong, localize, target, and have a protected drug interaction with the diseased.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86524997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00004
Sanjay S. Patel, Poojan N. Patel
Nanorobotics is the technology of creating machines or robots at or close to the microscopic scale of a nanometer. These devices are ranging in size from 0.1-10 micrometers and constructed of nanoscale. Due to their small size and wide functional properties, nanorobots have created exceptional prospects in medical, biomedical and pharmaceutical applications. The names nanobots, nanoids, nanites or nanomites have also been used to describe these hypothetical devices. Nanorobots are capable of performing task like actuating, sensing, signalling, information processing and intelligence at the nanoscale. Nanotechnology promises futuristic applications such as microscopic robots that assemble other machines or travel inside the body to deliver drugs or do microsurgery. Nanorobots could carry and deliver large amounts of anti-cancer drugs into cancerous cells without harming healthy cells, reducing the side effects related to current therapies like damage of the conventional chemotherapy. They are well used to cure HIV, cancer and other harmful diseases; they can restore lost tissue at the cellular level, useful for monitoring, diagnosing and fighting sickness. A recent discovery in the field of drug delivery is target therapy, which improves the diagnostic tests and medical devices.
{"title":"A Brief Review on Nanorobotics Applications in Medicine and Future Prospects","authors":"Sanjay S. Patel, Poojan N. Patel","doi":"10.52711/2231-5659.2023.00004","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00004","url":null,"abstract":"Nanorobotics is the technology of creating machines or robots at or close to the microscopic scale of a nanometer. These devices are ranging in size from 0.1-10 micrometers and constructed of nanoscale. Due to their small size and wide functional properties, nanorobots have created exceptional prospects in medical, biomedical and pharmaceutical applications. The names nanobots, nanoids, nanites or nanomites have also been used to describe these hypothetical devices. Nanorobots are capable of performing task like actuating, sensing, signalling, information processing and intelligence at the nanoscale. Nanotechnology promises futuristic applications such as microscopic robots that assemble other machines or travel inside the body to deliver drugs or do microsurgery. Nanorobots could carry and deliver large amounts of anti-cancer drugs into cancerous cells without harming healthy cells, reducing the side effects related to current therapies like damage of the conventional chemotherapy. They are well used to cure HIV, cancer and other harmful diseases; they can restore lost tissue at the cellular level, useful for monitoring, diagnosing and fighting sickness. A recent discovery in the field of drug delivery is target therapy, which improves the diagnostic tests and medical devices.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73217762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00002
Akhlaq Mustafa, Anas Iqbal Alvi, Mahesh Chandera, G. Javed, Asim Ali Khan
Due to their sweet flavor, impressive nutritional value, and various health benefits, mulberries are gaining popularity worldwide. Mulberries are colorful berries that are eaten both fresh and dried. They're a good source of iron, vitamin C, and several plant compounds and have been linked to lower cholesterol, blood sugar, and cancer risk. Mulberries are the fruits of mulberry trees (Morus sp.) and are related to figs and breadfruit. The trees are traditionally grown for their leaves mainly in Asia and North America as they’re the only food that silkworms eat. They carry colorful berries most commonly black, white, or red that are often made into wine, fruit juice, tea, jam, or canned foods, but can also be dried and eaten as a snack. Mulberries have a decent amount of fiber. The present communication carries an attempt to evaluate the study of phytochemical physicochemical parameters e. g. successive extractive values in different solvents, ash values, alcohol, water, and hexane soluble extractives, moisture contents, loss of weight on drying at 105oC, pH values of 1% and 10 % aqueous solutions, qualitative and quantitative mineral contents, and thin layer chromatography of different extracts. Besides, the qualitative and quantitative analysis of Phyto-constituents like alkaloids, total phenolics, tannins, sugar contents, crude fibers, proteins, and estimation of heavy metals, microbial loads, pesticide residues, and aflatoxins were also carried out which will be useful in the identification and control of the possible adulterations of the raw drug.
{"title":"Physico and phytochemical standardization of nutritionally rich mulberry fruits (Morus indica Linn)","authors":"Akhlaq Mustafa, Anas Iqbal Alvi, Mahesh Chandera, G. Javed, Asim Ali Khan","doi":"10.52711/2231-5659.2023.00002","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00002","url":null,"abstract":"Due to their sweet flavor, impressive nutritional value, and various health benefits, mulberries are gaining popularity worldwide. Mulberries are colorful berries that are eaten both fresh and dried. They're a good source of iron, vitamin C, and several plant compounds and have been linked to lower cholesterol, blood sugar, and cancer risk. Mulberries are the fruits of mulberry trees (Morus sp.) and are related to figs and breadfruit. The trees are traditionally grown for their leaves mainly in Asia and North America as they’re the only food that silkworms eat. They carry colorful berries most commonly black, white, or red that are often made into wine, fruit juice, tea, jam, or canned foods, but can also be dried and eaten as a snack. Mulberries have a decent amount of fiber. The present communication carries an attempt to evaluate the study of phytochemical physicochemical parameters e. g. successive extractive values in different solvents, ash values, alcohol, water, and hexane soluble extractives, moisture contents, loss of weight on drying at 105oC, pH values of 1% and 10 % aqueous solutions, qualitative and quantitative mineral contents, and thin layer chromatography of different extracts. Besides, the qualitative and quantitative analysis of Phyto-constituents like alkaloids, total phenolics, tannins, sugar contents, crude fibers, proteins, and estimation of heavy metals, microbial loads, pesticide residues, and aflatoxins were also carried out which will be useful in the identification and control of the possible adulterations of the raw drug.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77559308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.52711/2231-5659.2023.00006
Sara Sunil Mohite, Shahbaz Akhtar Momin, Samip Anant Niwate, Riya Madanlal Paliwal, Khushboo Chhotelal Yadav, S. Shukla, Dileep Kumar Bharati
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects.
{"title":"The Science of Aging and Longevity","authors":"Sara Sunil Mohite, Shahbaz Akhtar Momin, Samip Anant Niwate, Riya Madanlal Paliwal, Khushboo Chhotelal Yadav, S. Shukla, Dileep Kumar Bharati","doi":"10.52711/2231-5659.2023.00006","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00006","url":null,"abstract":"Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89512437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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