Pub Date : 2023-11-20DOI: 10.52711/2231-5659.2023.00052
Santosh B. Dighe, Dnyanda H. Kangude, Dnyaneshwari B. Kangune, Akanksha S. Tambe
The aim of the review is to discuss the Herbal drug technology. Herbal drug technology is a tool for converting botanical materials into therapeutically useful products and medicines. Today, herbal products obtained by integrating modern scientific techniques and traditional knowledge are gaining in-creased applications in drug discovery and development and there is increasing global demand for herbal drugs. Herbal medicines are widely used in all over world. Herbal drug shows more therapeutic effect and less side effects. Lots of population are preferred the herbal medicine. Here we present the outline of the quality control, different pharmacological action of various drugs. It also highlights on recent development in herbal drug. This review state that the herbal medicine having more therapeutic effectiveness. The study also shows that their regulatory status according to country to country. This review provide support and guide the researcher in recent development of herbal drug technology.
{"title":"Recent Advances in Herbal Drug Technology","authors":"Santosh B. Dighe, Dnyanda H. Kangude, Dnyaneshwari B. Kangune, Akanksha S. Tambe","doi":"10.52711/2231-5659.2023.00052","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00052","url":null,"abstract":"The aim of the review is to discuss the Herbal drug technology. Herbal drug technology is a tool for converting botanical materials into therapeutically useful products and medicines. Today, herbal products obtained by integrating modern scientific techniques and traditional knowledge are gaining in-creased applications in drug discovery and development and there is increasing global demand for herbal drugs. Herbal medicines are widely used in all over world. Herbal drug shows more therapeutic effect and less side effects. Lots of population are preferred the herbal medicine. Here we present the outline of the quality control, different pharmacological action of various drugs. It also highlights on recent development in herbal drug. This review state that the herbal medicine having more therapeutic effectiveness. The study also shows that their regulatory status according to country to country. This review provide support and guide the researcher in recent development of herbal drug technology.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139254835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.52711/2231-5659.2023.00046
Ambika Nand Jha, Varsha R. Gaikwad, Mashfa Asar, Akshay H. Shah, Sangita Shukla, Varsha Galani
Aim and objective: The Novel COVID-19 is global pandemic and Lockdown and leads to revoked of Ward Round participation and all Practical subjects Due to online study. In the First as well as second wave of Novel COVID 19 The country had to forcefully impose a lockdown as a preventive measure and lockdown had serious impact on Education of Pharm.D students. The current study is addressed to distinguish the impact of Novel COVID-19 on Study. Methodology: This cross-sectional online survey study by the sharing of Google form gathered demographic as well as questions related to impact of online study is conducted from 31th July to 30 August 2021. The survey google form is circulated using What Sapp, Email, Linked in and other social media platforms. Result: Total 180 participants in which 69 male and 111 female involve in our study and their Response received in Google Drive. The majority of the participants in the survey, especially those in their 5th, (clerkship) and 6th year (Internship) of study, were reported that lack of interaction with patients. Clinical clerkships have been cancelled or postpone in many of the college. Conclusions: The impact of Novel COVID 19 on Pharm.D student’s education has been significant, particularly affecting the practical knowledge in those subject which practical study is not possible during online study. The perception of Pharm.D students is classes taken via online platforms {Meet, Zoom etc} as beneficial as the conventional classroom study. This pandemic condition was associatory with frustrate and irritating impact on online study among the pharm.d students. During online study via any platforms learning outcomes should be regularly and strictly monitoree of knowledge towards their syllabus is may beneficial for us.
{"title":"Impact of Online Education during COVID-19 Pandemic among the Pharm. D. Students, A Web - Based Survey","authors":"Ambika Nand Jha, Varsha R. Gaikwad, Mashfa Asar, Akshay H. Shah, Sangita Shukla, Varsha Galani","doi":"10.52711/2231-5659.2023.00046","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00046","url":null,"abstract":"Aim and objective: The Novel COVID-19 is global pandemic and Lockdown and leads to revoked of Ward Round participation and all Practical subjects Due to online study. In the First as well as second wave of Novel COVID 19 The country had to forcefully impose a lockdown as a preventive measure and lockdown had serious impact on Education of Pharm.D students. The current study is addressed to distinguish the impact of Novel COVID-19 on Study. Methodology: This cross-sectional online survey study by the sharing of Google form gathered demographic as well as questions related to impact of online study is conducted from 31th July to 30 August 2021. The survey google form is circulated using What Sapp, Email, Linked in and other social media platforms. Result: Total 180 participants in which 69 male and 111 female involve in our study and their Response received in Google Drive. The majority of the participants in the survey, especially those in their 5th, (clerkship) and 6th year (Internship) of study, were reported that lack of interaction with patients. Clinical clerkships have been cancelled or postpone in many of the college. Conclusions: The impact of Novel COVID 19 on Pharm.D student’s education has been significant, particularly affecting the practical knowledge in those subject which practical study is not possible during online study. The perception of Pharm.D students is classes taken via online platforms {Meet, Zoom etc} as beneficial as the conventional classroom study. This pandemic condition was associatory with frustrate and irritating impact on online study among the pharm.d students. During online study via any platforms learning outcomes should be regularly and strictly monitoree of knowledge towards their syllabus is may beneficial for us.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.52711/2231-5659.2023.00053
Umair Akhtar, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar
Post-traumatic stress disorder (PTSD) is a mental health condition caused by witnessing or experiencing a terrifying event The anxiety disorder known as post-traumatic stress disorder (PTSD) is very common and has been linked to a higher risk of hypertension and cardiovascular disease. Types of PTSD are Normal Stress Response, Acute Stress Disorder, Uncomplicated, Complex, Comorbid. There are many factors that can contribute to someone developing posttraumatic stress disorder. Flashbacks, nightmares, excruciating anxiety, and uncontrollable thoughts about the incident are all possible symptoms. The amygdala is a component of the neural circuitry involved in emotional learning, fear, and anxiety. is a diverse disorder that has an impact on a person's behaviour, physical health, and mood as well as biological, psychological, and environmental factors. Anxiety types- Panic Disorder or OCD. There may be a feeling of disconnection between your mind and body that makes you feel out of control. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are frequently used in the treatment of PTSD and anxiety disorders, sertraline (Zoloft), paroxetine (Paxil), and fluoxetine (Fludac) approval for the treatment of PTSD. Many PTSD patients may turn to alcohol, drugs, or even suicide during this time in an effort to cope with the agoraphobia, depression, and nightmares.
{"title":"Approaches towards Anxiety due to Post Traumatic Stress Disorder : A Review","authors":"Umair Akhtar, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar","doi":"10.52711/2231-5659.2023.00053","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00053","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a mental health condition caused by witnessing or experiencing a terrifying event The anxiety disorder known as post-traumatic stress disorder (PTSD) is very common and has been linked to a higher risk of hypertension and cardiovascular disease. Types of PTSD are Normal Stress Response, Acute Stress Disorder, Uncomplicated, Complex, Comorbid. There are many factors that can contribute to someone developing posttraumatic stress disorder. Flashbacks, nightmares, excruciating anxiety, and uncontrollable thoughts about the incident are all possible symptoms. The amygdala is a component of the neural circuitry involved in emotional learning, fear, and anxiety. is a diverse disorder that has an impact on a person's behaviour, physical health, and mood as well as biological, psychological, and environmental factors. Anxiety types- Panic Disorder or OCD. There may be a feeling of disconnection between your mind and body that makes you feel out of control. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are frequently used in the treatment of PTSD and anxiety disorders, sertraline (Zoloft), paroxetine (Paxil), and fluoxetine (Fludac) approval for the treatment of PTSD. Many PTSD patients may turn to alcohol, drugs, or even suicide during this time in an effort to cope with the agoraphobia, depression, and nightmares.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour. However, the success of these approaches depends on the physical and chemical properties of the molecules being developed. The development of drug products with superior physicochemical characteristics, such as melting point, tablet ability, solubility, stability, bioavailability, and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient is greatly facilitated by co-crystallization of drug substances. All the components of a cocrystal, which is a stoichiometric homogeneous multicomponent system connected by non-covalent interactions, are solid under ambient conditions.
{"title":"Cocrystal: A Review on the Design and Preparation of Pharmaceutical Cocrystals","authors":"Tanmay Jit, Dibyendu Shil, Ramesh Kumari Dasgupta, Sanglap Mallick, Saptarshi Mukherjee","doi":"10.52711/2231-5659.2023.00050","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00050","url":null,"abstract":"The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour. However, the success of these approaches depends on the physical and chemical properties of the molecules being developed. The development of drug products with superior physicochemical characteristics, such as melting point, tablet ability, solubility, stability, bioavailability, and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient is greatly facilitated by co-crystallization of drug substances. All the components of a cocrystal, which is a stoichiometric homogeneous multicomponent system connected by non-covalent interactions, are solid under ambient conditions.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"55 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00032
Dhananjay D. Chaudhari, Karishma. P. Bhadane, Priyanka. V. Pawar
Humans are exposed to a variety of different and persistent DNA-damaging agents, some of which have been identified as carcinogens. DNA damage can occur from exposure to exogenous agents, but damage from endogenous processes is more common. That is, epidemiological studies of migrant populations from low-cancer-risk areas to high-cancer-incidence countries suggest the role of environmental factors and/or lifestyle as important players in the etiology of cancer. As a result, it can be assumed that carcinogens found in the environment or our diet are to blame. Carcinogen exposure is associated with various forms of DNA damage, including single-strand breaks, double-strand breaks, chemical DNA cross-links, oxidative stress, and DNA-DNA or DNA-protein breaks. This review focuses on DNA damage caused by the following carcinogens: polycyclic aromatic hydrocarbons, heterocyclic aromatic amines, mycotoxins, ultraviolet light, ionizing radiation, aristolochic acid, nitrosamines, and particulate matter. In addition, we discuss several cancers for which molecular epidemiological evidence suggests that these agents are etiological risk factors. The complex role that carcinogens play in the pathophysiology of cancer development remains unclear, but DNA damage remains central to this process.
{"title":"A Short Review on Carcinogenicity","authors":"Dhananjay D. Chaudhari, Karishma. P. Bhadane, Priyanka. V. Pawar","doi":"10.52711/2231-5659.2023.00032","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00032","url":null,"abstract":"Humans are exposed to a variety of different and persistent DNA-damaging agents, some of which have been identified as carcinogens. DNA damage can occur from exposure to exogenous agents, but damage from endogenous processes is more common. That is, epidemiological studies of migrant populations from low-cancer-risk areas to high-cancer-incidence countries suggest the role of environmental factors and/or lifestyle as important players in the etiology of cancer. As a result, it can be assumed that carcinogens found in the environment or our diet are to blame. Carcinogen exposure is associated with various forms of DNA damage, including single-strand breaks, double-strand breaks, chemical DNA cross-links, oxidative stress, and DNA-DNA or DNA-protein breaks. This review focuses on DNA damage caused by the following carcinogens: polycyclic aromatic hydrocarbons, heterocyclic aromatic amines, mycotoxins, ultraviolet light, ionizing radiation, aristolochic acid, nitrosamines, and particulate matter. In addition, we discuss several cancers for which molecular epidemiological evidence suggests that these agents are etiological risk factors. The complex role that carcinogens play in the pathophysiology of cancer development remains unclear, but DNA damage remains central to this process.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86468213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00017
S. Samajdar
Modern pharmacological techniques can be complemented by plants, therefore conventional medicinal plant analysis has risen globally over the years. As computer science advanced, in silico methods such as network analysis and screening were widely used to provide insight on the pharmacological underpinnings of the actions of traditional medicinal plants. In this method, network pharmacology, in silico screening, and pharmacokinetic screening can increase the number of active substances among the candidates and reveal the therapeutic plant's mode of action. The application of the insilico ADME tool SwissADME for the pharmacological and pharmacognostic profiling of Piper longum Lam is the current focus. The findings of these investigations can be used by researchers to look into in vitro and in vivo studies to uncover the pharmacological underpinnings of conventional medicinal herbs.
{"title":"In silico ADME prediction of Phytochemicals present in Piper longum","authors":"S. Samajdar","doi":"10.52711/2231-5659.2023.00017","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00017","url":null,"abstract":"Modern pharmacological techniques can be complemented by plants, therefore conventional medicinal plant analysis has risen globally over the years. As computer science advanced, in silico methods such as network analysis and screening were widely used to provide insight on the pharmacological underpinnings of the actions of traditional medicinal plants. In this method, network pharmacology, in silico screening, and pharmacokinetic screening can increase the number of active substances among the candidates and reveal the therapeutic plant's mode of action. The application of the insilico ADME tool SwissADME for the pharmacological and pharmacognostic profiling of Piper longum Lam is the current focus. The findings of these investigations can be used by researchers to look into in vitro and in vivo studies to uncover the pharmacological underpinnings of conventional medicinal herbs.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82854475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00021
S. Ansari, S. Khan, I. Parab
Sugar molecules that are arranged in rings of various sizes are known as cyclodextrins. A family of cyclic oligomers known as cyclodextrins (CDs) is produced when starch is digested more quickly. They are homogenous, crystalline, non-hygroscopic, hydrophobic within, and hydrophilic outside, and require comparable structures. The following article lists the cyclodextrins' characteristics. Cyclodextrin's purpose is discussed. The method utilised to form the inclusion complex is mentioned and thoroughly discussed, as well as the formation of inclusion complex in detail. A number of commercially available formulations containing cyclodextrin derivatives were included. cyclodextrin's usage in several medication delivery systems. Uses and potential uses for cyclodextrin and its derivative.
{"title":"Cyclodextrin and its Derivative in Drug Delivery System","authors":"S. Ansari, S. Khan, I. Parab","doi":"10.52711/2231-5659.2023.00021","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00021","url":null,"abstract":"Sugar molecules that are arranged in rings of various sizes are known as cyclodextrins. A family of cyclic oligomers known as cyclodextrins (CDs) is produced when starch is digested more quickly. They are homogenous, crystalline, non-hygroscopic, hydrophobic within, and hydrophilic outside, and require comparable structures. The following article lists the cyclodextrins' characteristics. Cyclodextrin's purpose is discussed. The method utilised to form the inclusion complex is mentioned and thoroughly discussed, as well as the formation of inclusion complex in detail. A number of commercially available formulations containing cyclodextrin derivatives were included. cyclodextrin's usage in several medication delivery systems. Uses and potential uses for cyclodextrin and its derivative.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73350069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00023
Nandkumar R. Kadam, Manisha M. Rokade
A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into systemic circulation. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations. Transdermal drugs are self- contained, discrete dosage form. It delivers a drug through intact skin at a controlled rate into the systemic circulation. Delivery rate is controlled by the skin or membrane in the delivery system. It is a sophisticated complex drug delivery system which is difficult to formulate. It requires specialized manufacturing process/equipment. The materials of construction, configuration and combination of the drug with the proper cosolvent, excipient, penetration enhancer, and membrane are carefully selected and matched to optimize adhesive properties and drug delivery requirements. Several transdermal products and applications include hormone replacement therapy, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. Formulated to deliver the drug at optimized rate into the systemic circulation should adhere to the skin for the expected duration should not cause any skin irritation and/or sensitization, enhancing bioavailability via bypassing first pass metabolism, minimizing pharmacokinetic peaks and troughs, improving tolerability and dosing increasing patient compliance in continuous delivery. This review article provides an overview of TDDS, its advantages over conventional dosage forms, Limitations, various components of Transdermal patches, types of Transdermal patches, methods of preparation and Ideal requirements for TDDS, regulatory issues over transdermal drug delivery, its physicochemical methods of evaluation, therapeutic uses and recent advances in transdermal drug delivery system.1
{"title":"Transdermal Drug Delivery System","authors":"Nandkumar R. Kadam, Manisha M. Rokade","doi":"10.52711/2231-5659.2023.00023","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00023","url":null,"abstract":"A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into systemic circulation. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations. Transdermal drugs are self- contained, discrete dosage form. It delivers a drug through intact skin at a controlled rate into the systemic circulation. Delivery rate is controlled by the skin or membrane in the delivery system. It is a sophisticated complex drug delivery system which is difficult to formulate. It requires specialized manufacturing process/equipment. The materials of construction, configuration and combination of the drug with the proper cosolvent, excipient, penetration enhancer, and membrane are carefully selected and matched to optimize adhesive properties and drug delivery requirements. Several transdermal products and applications include hormone replacement therapy, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. Formulated to deliver the drug at optimized rate into the systemic circulation should adhere to the skin for the expected duration should not cause any skin irritation and/or sensitization, enhancing bioavailability via bypassing first pass metabolism, minimizing pharmacokinetic peaks and troughs, improving tolerability and dosing increasing patient compliance in continuous delivery. This review article provides an overview of TDDS, its advantages over conventional dosage forms, Limitations, various components of Transdermal patches, types of Transdermal patches, methods of preparation and Ideal requirements for TDDS, regulatory issues over transdermal drug delivery, its physicochemical methods of evaluation, therapeutic uses and recent advances in transdermal drug delivery system.1","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82816436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00026
A. Saxena, Gayatri Tiwari, V. Bhatt
The primary goal of this review is to examine and test the efficacy of new gastroretentive techniques for dealing with drugs that are without difficulty absorbed from the gastrointestinal tract and have very short half-lives that are rapidly removed from the systemic circulation. To have an excellent therapeutic effect, these drugs must be taken frequently. A systematic search and collection of reviewed information from Pubmed, Embase, Scopus, and Scholar databases were searched from inception to identify studies on current medications. Several methods are used to retain the drug and enhancethe bioavailability, conventional effect versus floating effect. The current approaches of floating drug delivery systems can be used to reduce complex tasks associated with conventional oral dose forms and release the drug at a specific absorption site, which has been shown in these reviews to be effective in targeting drug release at a specific absorption site to improve the bioavailability of a specific drug material. Based on the data presented, the conclusion is that it can also provide local medication delivery in the stomach and proximal small intestine. To achieve the system with the intended activity, it is critical to select the right technology for the right goal via asuitable mechanism of action. These technologies can solve various problems while improving a pharmaceutical dosage form.
{"title":"A Review on Novel Approach of Gastro-Retentive Oral Drug Delivery System","authors":"A. Saxena, Gayatri Tiwari, V. Bhatt","doi":"10.52711/2231-5659.2023.00026","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00026","url":null,"abstract":"The primary goal of this review is to examine and test the efficacy of new gastroretentive techniques for dealing with drugs that are without difficulty absorbed from the gastrointestinal tract and have very short half-lives that are rapidly removed from the systemic circulation. To have an excellent therapeutic effect, these drugs must be taken frequently. A systematic search and collection of reviewed information from Pubmed, Embase, Scopus, and Scholar databases were searched from inception to identify studies on current medications. Several methods are used to retain the drug and enhancethe bioavailability, conventional effect versus floating effect. The current approaches of floating drug delivery systems can be used to reduce complex tasks associated with conventional oral dose forms and release the drug at a specific absorption site, which has been shown in these reviews to be effective in targeting drug release at a specific absorption site to improve the bioavailability of a specific drug material. Based on the data presented, the conclusion is that it can also provide local medication delivery in the stomach and proximal small intestine. To achieve the system with the intended activity, it is critical to select the right technology for the right goal via asuitable mechanism of action. These technologies can solve various problems while improving a pharmaceutical dosage form.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81081757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00020
Vidya Ashok Kheradkar, Jameel Ahmed S. Mulla
Nanotechnology includes nanosuspensions. Nanotechnology has become a huge area in the world of medicine. An appealing and promising approach to address the lipophilic like bio-available and poor solvability concerning the pharmaceuticals is nanosuspension. The majority of recently developed medications have poor water solubility. Drug formulation is usually complicated by medicines' limited water solubility. There are numerous standard methods for improving the solubility of pharmaceuticals that are poorly soluble, including Media Milling, Homogenization, precipitation technique, et cetera. A new approach in medication development is the development disintegrable medicinal formulations using nanotechnology. Particle sizes used in nanotechnology range are from 1 to 1000 nm. The increase in dissolving rate that results from drug particle size reduction into the submicron region naturally improves bioavailability. An efficient new method for improving the dissolution of low soluble in water medicines is nanosuspension technology. A nanosuspension improves the safety and effectiveness of a medicine by addressing issues with lipophilic like bio-available and poor solvability, as well as by changing the pharmacokinetics.
{"title":"Nanosuspension: A Novel Technology for Drug Delivery","authors":"Vidya Ashok Kheradkar, Jameel Ahmed S. Mulla","doi":"10.52711/2231-5659.2023.00020","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00020","url":null,"abstract":"Nanotechnology includes nanosuspensions. Nanotechnology has become a huge area in the world of medicine. An appealing and promising approach to address the lipophilic like bio-available and poor solvability concerning the pharmaceuticals is nanosuspension. The majority of recently developed medications have poor water solubility. Drug formulation is usually complicated by medicines' limited water solubility. There are numerous standard methods for improving the solubility of pharmaceuticals that are poorly soluble, including Media Milling, Homogenization, precipitation technique, et cetera. A new approach in medication development is the development disintegrable medicinal formulations using nanotechnology. Particle sizes used in nanotechnology range are from 1 to 1000 nm. The increase in dissolving rate that results from drug particle size reduction into the submicron region naturally improves bioavailability. An efficient new method for improving the dissolution of low soluble in water medicines is nanosuspension technology. A nanosuspension improves the safety and effectiveness of a medicine by addressing issues with lipophilic like bio-available and poor solvability, as well as by changing the pharmacokinetics.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87218831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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