Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00022
Aditi A. Kokate, Sunita R. Kumavat, Rohan R. Vakhariya, S. Mohite
Herbal medicines are advancing subjects in medicine, and we must, of course, learn more about them. Complementary, alternative, and traditional medicines are key contributors of herbal medication guidance, but modern medicine first must demonstrate these guidelines through research methodology prior to actually incorporating them in discipline. Herbal medicines evermore being used as complimentary remedies for the regime of epidemics. Edema is our body's natural defense answer to potentially dangerous sensory input such as allergic reactions and/or epithelial injury; on either hand, an uncontrolled inflammatory response is the possible cause of a range of ailments such as allergies, heart dysfunctions, metabolic disorders, cancer, and autoimmune conditions, seeking to impose an enormous economic burden on individuals and, by extension, society. We manifest some herbs for which the anti- inflammatory assets have been investigated throughout experimental and clinical trials. This review aims to accomplish multi-dimensional therapeutic strategies to inflammatory processes through the utilization of herbal and lifestyle modification. In this review, we have tried to better understand the plants with its anti-inflammatory effects.
{"title":"Review on Multi-Dimensional Therapeutic Strategies and Potential Anti- Inflammatory Medicinal Plants","authors":"Aditi A. Kokate, Sunita R. Kumavat, Rohan R. Vakhariya, S. Mohite","doi":"10.52711/2231-5659.2023.00022","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00022","url":null,"abstract":"Herbal medicines are advancing subjects in medicine, and we must, of course, learn more about them. Complementary, alternative, and traditional medicines are key contributors of herbal medication guidance, but modern medicine first must demonstrate these guidelines through research methodology prior to actually incorporating them in discipline. Herbal medicines evermore being used as complimentary remedies for the regime of epidemics. Edema is our body's natural defense answer to potentially dangerous sensory input such as allergic reactions and/or epithelial injury; on either hand, an uncontrolled inflammatory response is the possible cause of a range of ailments such as allergies, heart dysfunctions, metabolic disorders, cancer, and autoimmune conditions, seeking to impose an enormous economic burden on individuals and, by extension, society. We manifest some herbs for which the anti- inflammatory assets have been investigated throughout experimental and clinical trials. This review aims to accomplish multi-dimensional therapeutic strategies to inflammatory processes through the utilization of herbal and lifestyle modification. In this review, we have tried to better understand the plants with its anti-inflammatory effects.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76746586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00025
P. R. Dhapake, J. Baheti, P. Suruse
Protein drugs are the biological drug which cannot be administered orally due to problems related to degradation of protein complex in the acidic and protease-rich environment of the gastrointestinal (GI) tract. High molecular weight of protein drugs often results in poor absorption into the periphery when administered orally. Thus, generally protein drugs administered by injection. Most of the proteins drug have a short serum half-life which need to be administered frequently or in high doses to achieve the therapeutic effectiveness. Frequent dosing of these drugs by injection make patient uncomfortable and cumulative doses also may produce severe side effect due to unspecific binding of drug to non-targeted tissue. So, these difficulties in the administration of protein drugs provides the motivation for preparation of novel drug delivery systems (DDSs) In which drug will protect form biological and chemical degradation in the body and able to release drug for long time after oral administration. Encapsulation of proteins drug in a polymeric nanoparticle has been a widely investigated technology for protein drug delivery. Some ligand enhances the penetration of nanoparticles across the intestinal epithelial cell thus the ligand conjugated polymer can use to enhance the penetration of protein drug across the intestine.
{"title":"Nanoparticulate Drug Delivery: A Promising Drug Delivery for Protein Drug","authors":"P. R. Dhapake, J. Baheti, P. Suruse","doi":"10.52711/2231-5659.2023.00025","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00025","url":null,"abstract":"Protein drugs are the biological drug which cannot be administered orally due to problems related to degradation of protein complex in the acidic and protease-rich environment of the gastrointestinal (GI) tract. High molecular weight of protein drugs often results in poor absorption into the periphery when administered orally. Thus, generally protein drugs administered by injection. Most of the proteins drug have a short serum half-life which need to be administered frequently or in high doses to achieve the therapeutic effectiveness. Frequent dosing of these drugs by injection make patient uncomfortable and cumulative doses also may produce severe side effect due to unspecific binding of drug to non-targeted tissue. So, these difficulties in the administration of protein drugs provides the motivation for preparation of novel drug delivery systems (DDSs) In which drug will protect form biological and chemical degradation in the body and able to release drug for long time after oral administration. Encapsulation of proteins drug in a polymeric nanoparticle has been a widely investigated technology for protein drug delivery. Some ligand enhances the penetration of nanoparticles across the intestinal epithelial cell thus the ligand conjugated polymer can use to enhance the penetration of protein drug across the intestine.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88144695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00031
Tushar N. Sonawane, Vinit S. Khairnar, Rushikesh R. Chaudhari
Spirulina is a multicellular and filamentous blue-green microalga that is part of the genera Spirulina and Arthrospira and contains about 15 species. Of these, Arthrospira platensis is the most common and widely available spirulina and most published studies and public health decisions refer to this particular species and became famous after it was successfully used by NASA as a space food supplement for space travel. it grows and grows in water, can be harvested and processed easily. Spirulina cultivation requires adequate air, agitation and light energy to improve biomass yield, cell production, growth rate, and protein content. It has a very high content of macro and micronutrients, essential amino acids, proteins, fats, Vitamins, minerals and anti-Oxidants. It also has a very high content of vitamin B12, a good source of beta-carotene, iron, calcium and calcium. phosphorus. One gram of Spirulina protein is equivalent to one pound of various vegetables. In recent years, spirulina has attracted scientific attention, not only for its various health benefits, but also for its limited level of understanding of the mechanisms of its various components. Since being a 'complete source of protein, spirulina and its components have been shown to have beneficial effects on a wide range of human health indicators ranging from malnutrition to antioxidant substances. Important growth parameters have been researched to improve Spirulina biomass production with quality and capacity by default. This review provides useful information on the effective planting technology of Spirulina. Bulk plantings and new structures are needed to supplement the normal diet with a Spirulina-based protein program.
{"title":"A Review Article on ‘Spirulina’","authors":"Tushar N. Sonawane, Vinit S. Khairnar, Rushikesh R. Chaudhari","doi":"10.52711/2231-5659.2023.00031","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00031","url":null,"abstract":"Spirulina is a multicellular and filamentous blue-green microalga that is part of the genera Spirulina and Arthrospira and contains about 15 species. Of these, Arthrospira platensis is the most common and widely available spirulina and most published studies and public health decisions refer to this particular species and became famous after it was successfully used by NASA as a space food supplement for space travel. it grows and grows in water, can be harvested and processed easily. Spirulina cultivation requires adequate air, agitation and light energy to improve biomass yield, cell production, growth rate, and protein content. It has a very high content of macro and micronutrients, essential amino acids, proteins, fats, Vitamins, minerals and anti-Oxidants. It also has a very high content of vitamin B12, a good source of beta-carotene, iron, calcium and calcium. phosphorus. One gram of Spirulina protein is equivalent to one pound of various vegetables. In recent years, spirulina has attracted scientific attention, not only for its various health benefits, but also for its limited level of understanding of the mechanisms of its various components. Since being a 'complete source of protein, spirulina and its components have been shown to have beneficial effects on a wide range of human health indicators ranging from malnutrition to antioxidant substances. Important growth parameters have been researched to improve Spirulina biomass production with quality and capacity by default. This review provides useful information on the effective planting technology of Spirulina. Bulk plantings and new structures are needed to supplement the normal diet with a Spirulina-based protein program.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82031852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00029
Nikam Swati, Velhal Atish, Jadhav Prakash
Solid Dispersion is one of the most ancient most extensively used procedures for increasing a slowly dissolving substance's solubility substances. Solid dispersion is prepared using a variety of pharmaceutically suitable ingredients and new technology. Solid dispersions were created through a variety of methods such as kneading, co-milling, fusing, solvent evaporation, and other solvent-related techniques. Choosing the right manufacturing technique and carrier is critical for producing a homogeneous product with good stability and biological activity. The review focuses on categorization of solid dispersion based on recent advancement and various techniques involved to improve solubility.
{"title":"Review on Laboratory Scale Solid Dispersion Techniques","authors":"Nikam Swati, Velhal Atish, Jadhav Prakash","doi":"10.52711/2231-5659.2023.00029","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00029","url":null,"abstract":"Solid Dispersion is one of the most ancient most extensively used procedures for increasing a slowly dissolving substance's solubility substances. Solid dispersion is prepared using a variety of pharmaceutically suitable ingredients and new technology. Solid dispersions were created through a variety of methods such as kneading, co-milling, fusing, solvent evaporation, and other solvent-related techniques. Choosing the right manufacturing technique and carrier is critical for producing a homogeneous product with good stability and biological activity. The review focuses on categorization of solid dispersion based on recent advancement and various techniques involved to improve solubility.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88041229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00016
G. P., S. N, R. A
Before the age of 30, most age-related physiological functions reach their peak and then slowly diminish; while this decline may be crucial under stress, it often has little to no impact on daily activities. The study's objective was to evaluate the physical health and overall well-being of the elderly people in a rural area of Chennai. With a sample size of 384 participants, a prospective cross-sectional study employing questionnaires was conducted. The survey evaluated the physical health and overall quality of life of the elderly population. The current investigation came to the conclusion that the physical and mental health of older populations is average. The majority of participants are dissatisfied with their lives, haven't engaged in any social club activities, and need assistance from others to get through their days.
{"title":"A Study on Physical Condition and Quality of Life among Geriatric Population in A Rural Area of Chennai - A Cross Sectional Study","authors":"G. P., S. N, R. A","doi":"10.52711/2231-5659.2023.00016","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00016","url":null,"abstract":"Before the age of 30, most age-related physiological functions reach their peak and then slowly diminish; while this decline may be crucial under stress, it often has little to no impact on daily activities. The study's objective was to evaluate the physical health and overall well-being of the elderly people in a rural area of Chennai. With a sample size of 384 participants, a prospective cross-sectional study employing questionnaires was conducted. The survey evaluated the physical health and overall quality of life of the elderly population. The current investigation came to the conclusion that the physical and mental health of older populations is average. The majority of participants are dissatisfied with their lives, haven't engaged in any social club activities, and need assistance from others to get through their days.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87081183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00028
Vivek Shinde, Gayatri Patil, A. Patil, Pavankumar Wankhede
In a scientific article, Salter defines asthma as "paradoxical dyspnoea of a particular nature with intervals of healthy respiration between attacks. At an early age, asthma gets developed in children. The common symptoms include shortness of breath, fast heart rate, throat irritation, wheezing, cough, and chest pain. Current treatment for bronchial asthma includes corticosteroids, bronchodilators, mast cell stabilizers, Anti IgE antibodies, etc. The ayurvedic remedies along with deep breathing exercises and diet may cure the symptoms and severity of asthma that affects the respiratory system. Natural plants with bronchodilating, asthmatic, and antihistaminic activity such as black pepper, kali musli, kutki, castor oil, and tamarind have been briefly explained in this article with specific animal models used. Ayurvedic formulations with polyherbal compounds are also as effective as allopathic medications giving no side effects and maximum benefits to health. Formulations like kabasura, shirishadi, DSK, and DSR along with their compositions, and plant parts used in the extract have also been explained. Ayurvedic practitioners have also reported herbal treatment as effective for bronchial asthma. Dietary modifications, exercises, and lifestyle changes with herbal remedies can be key to curing and preventing symptoms of bronchial asthma to have a healthy life.
{"title":"Asthma: Types, Pathophysiology and Herbal remedies","authors":"Vivek Shinde, Gayatri Patil, A. Patil, Pavankumar Wankhede","doi":"10.52711/2231-5659.2023.00028","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00028","url":null,"abstract":"In a scientific article, Salter defines asthma as \"paradoxical dyspnoea of a particular nature with intervals of healthy respiration between attacks. At an early age, asthma gets developed in children. The common symptoms include shortness of breath, fast heart rate, throat irritation, wheezing, cough, and chest pain. Current treatment for bronchial asthma includes corticosteroids, bronchodilators, mast cell stabilizers, Anti IgE antibodies, etc. The ayurvedic remedies along with deep breathing exercises and diet may cure the symptoms and severity of asthma that affects the respiratory system. Natural plants with bronchodilating, asthmatic, and antihistaminic activity such as black pepper, kali musli, kutki, castor oil, and tamarind have been briefly explained in this article with specific animal models used. Ayurvedic formulations with polyherbal compounds are also as effective as allopathic medications giving no side effects and maximum benefits to health. Formulations like kabasura, shirishadi, DSK, and DSR along with their compositions, and plant parts used in the extract have also been explained. Ayurvedic practitioners have also reported herbal treatment as effective for bronchial asthma. Dietary modifications, exercises, and lifestyle changes with herbal remedies can be key to curing and preventing symptoms of bronchial asthma to have a healthy life.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75442652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00019
Rahul Jodh, M. Tawar, Gaurav Mude, Hitesh Khodaskar, Karishma Kinekar
Ketoconazole is a synthetic imidazole antifungal agent that can be used to treat surface fungal infections, genital, chronic mucocutaneous candidosis, and candidosis. Ketoconazole is a synthetic imidazole derivative that is effective after oral administration, unlike older imidazole antifungals like miconazole and clotrimazole. It works well for fungal infections on the skin, such as dermatophytosis and genital candidiasis. It has become useful for the treatment of persistent mucocutaneous candidiasis. In immunocompromised individuals, ketoconazole is also used to prevent fungal infections. It has lately been utilised as a therapy for advanced prostatic cancer because it inhibits the production of adrenal sex hormone. Although oral ketoconazole has been subjected to labelling modifications and market withdrawal because of substantial adverse effects, topical ketoconazole is widely regarded to be efficacious, safe, and best for treating superficial fungal infections. Onychomycosis, blepharitis, and hair loss are some of the new dermatologic indications for topical ketoconazole usage.
{"title":"Ketoconazole: A Promising Drug for Fungal Infections","authors":"Rahul Jodh, M. Tawar, Gaurav Mude, Hitesh Khodaskar, Karishma Kinekar","doi":"10.52711/2231-5659.2023.00019","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00019","url":null,"abstract":"Ketoconazole is a synthetic imidazole antifungal agent that can be used to treat surface fungal infections, genital, chronic mucocutaneous candidosis, and candidosis. Ketoconazole is a synthetic imidazole derivative that is effective after oral administration, unlike older imidazole antifungals like miconazole and clotrimazole. It works well for fungal infections on the skin, such as dermatophytosis and genital candidiasis. It has become useful for the treatment of persistent mucocutaneous candidiasis. In immunocompromised individuals, ketoconazole is also used to prevent fungal infections. It has lately been utilised as a therapy for advanced prostatic cancer because it inhibits the production of adrenal sex hormone. Although oral ketoconazole has been subjected to labelling modifications and market withdrawal because of substantial adverse effects, topical ketoconazole is widely regarded to be efficacious, safe, and best for treating superficial fungal infections. Onychomycosis, blepharitis, and hair loss are some of the new dermatologic indications for topical ketoconazole usage.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85484979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00024
Samreen Shaikh, Geeta Bhagwat
Hyperlipidemia is the major cause of atherosclerosis in which the lipid level in the blood plasma increases which leads to the formation of atherosclerotic plaque in the blood stream. Antihyperlipidemic drugs are used to reduce the high level of lipids and lipoproteins in the blood. HMG CoA reductase (Statin drugs) are the most potent group of antihyperlipidemic drugs and it works by inhibiting the Hydroxymethylglutaryl-coenzyme A (HMG CoA) reductase enzyme in the cholesterol synthesis. The most commonly used drug for decreasing low density lipoprotein (LDL) cholesterol is simvastatin. I is more efficacious as compared to Atorvastatin in increasing high density lipoprotein (HDL) cholesterol level. Simvastatin (SIM) is lipophilic in nature and is a perfect candidate for a novel colloidal drug delivery system (CDDS). CDDS delivers the drug to its target site to enhance the control release and to achieve the maximum therapeutic effect. This concept of targeting includes the nanoparticulate system such as Liposomes, Solid lipid nanoparticles (SLNs), Polymeric nanoparticles, Niosomes, Nanoemulsion and Metallic nanoparticles.
{"title":"Colloidal Drug Delivery of Simvastatin for Prolonged Drug Release and Increased Bioavailability","authors":"Samreen Shaikh, Geeta Bhagwat","doi":"10.52711/2231-5659.2023.00024","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00024","url":null,"abstract":"Hyperlipidemia is the major cause of atherosclerosis in which the lipid level in the blood plasma increases which leads to the formation of atherosclerotic plaque in the blood stream. Antihyperlipidemic drugs are used to reduce the high level of lipids and lipoproteins in the blood. HMG CoA reductase (Statin drugs) are the most potent group of antihyperlipidemic drugs and it works by inhibiting the Hydroxymethylglutaryl-coenzyme A (HMG CoA) reductase enzyme in the cholesterol synthesis. The most commonly used drug for decreasing low density lipoprotein (LDL) cholesterol is simvastatin. I is more efficacious as compared to Atorvastatin in increasing high density lipoprotein (HDL) cholesterol level. Simvastatin (SIM) is lipophilic in nature and is a perfect candidate for a novel colloidal drug delivery system (CDDS). CDDS delivers the drug to its target site to enhance the control release and to achieve the maximum therapeutic effect. This concept of targeting includes the nanoparticulate system such as Liposomes, Solid lipid nanoparticles (SLNs), Polymeric nanoparticles, Niosomes, Nanoemulsion and Metallic nanoparticles.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89418539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00018
Shweta S. Bobade, Komal D. Pol, Mahesh S. Mali, Pradnya N. Jagtap, Sumit K. Musale
Motor neuron disease (MND) is a devastating neurodegenerative disease with a poor prognosis and severe disability. Many potential external risk factors have been proposed as part of a gene-environment interaction in the etiology of MND. This result is also supported by current hypotheses concerning the cellular and genetic origins of MND. A motor neuronopathy that exacerbate frontotemporal dementia is known as MND (FTD). Frontal and temporal neocortical atrophy induce severe personality changes, inappropriate social conduct, and executive difficulties in people with FTD. Motor neuron disease causes symptoms such as bulbar palsy and limb amyotrophy. Frontal executive function deficits are seen in MND/amyotrophic lateral sclerosis (ALS) patients who are not considered demented. Furthermore, MRI has revealed anomalies in the frontal lobe. MND, according to Ayurveda, are caused by Vata Dosha. Vatais in charge of the nervous system's autonomic, peripheral, and central functions. It oversees the brain's cognitive and neurological processes. This article gives the information about the Ayurveda in management of MND, Panchakarma treatments for MND, various herbs and herbal formulations like Ashwagndha, Brahmi, Gotu kola, Shilajit, Kapakacchu, VrihatVatchintamani Ras, Medhyachurna used in the treatment and management of MND.
{"title":"A Review on Ayurved in the Treatment and Management of Motor Neuron Disease","authors":"Shweta S. Bobade, Komal D. Pol, Mahesh S. Mali, Pradnya N. Jagtap, Sumit K. Musale","doi":"10.52711/2231-5659.2023.00018","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00018","url":null,"abstract":"Motor neuron disease (MND) is a devastating neurodegenerative disease with a poor prognosis and severe disability. Many potential external risk factors have been proposed as part of a gene-environment interaction in the etiology of MND. This result is also supported by current hypotheses concerning the cellular and genetic origins of MND. A motor neuronopathy that exacerbate frontotemporal dementia is known as MND (FTD). Frontal and temporal neocortical atrophy induce severe personality changes, inappropriate social conduct, and executive difficulties in people with FTD. Motor neuron disease causes symptoms such as bulbar palsy and limb amyotrophy. Frontal executive function deficits are seen in MND/amyotrophic lateral sclerosis (ALS) patients who are not considered demented. Furthermore, MRI has revealed anomalies in the frontal lobe. MND, according to Ayurveda, are caused by Vata Dosha. Vatais in charge of the nervous system's autonomic, peripheral, and central functions. It oversees the brain's cognitive and neurological processes. This article gives the information about the Ayurveda in management of MND, Panchakarma treatments for MND, various herbs and herbal formulations like Ashwagndha, Brahmi, Gotu kola, Shilajit, Kapakacchu, VrihatVatchintamani Ras, Medhyachurna used in the treatment and management of MND.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81036475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.52711/2231-5659.2023.00027
Rishabh Aggarwal, Ashutosh Chamoli, M. Rawat, A. Nautiyal
A parasitic infection of major worldwide significance is malaria. One of the most common illnesses in humans worldwide, malaria is nevertheless comparatively rare in wealthy nations where it primarily affects travellers who have just returned from endemic areas. Malaria is a major source of sickness and mortality in areas where it is endemic, as well as a major social and economic burden. The current focus of malaria control is to lower attributable morbidity and mortality. In some endemic locations, targeted chemoprophylaxis and the use of bed nets treated with pesticide have been effective. Personal safety precautions and the proper chemoprophylaxis can considerably lower the risk of infection for travellers to malaria-endemic areas. It is crucial to assess febrile travellers as away, have a high level of suspicion for malaria, make an accurate diagnosis right away, and start the proper antimalarial treatment.
{"title":"A Review on Malaria, its Control and Management","authors":"Rishabh Aggarwal, Ashutosh Chamoli, M. Rawat, A. Nautiyal","doi":"10.52711/2231-5659.2023.00027","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00027","url":null,"abstract":"A parasitic infection of major worldwide significance is malaria. One of the most common illnesses in humans worldwide, malaria is nevertheless comparatively rare in wealthy nations where it primarily affects travellers who have just returned from endemic areas. Malaria is a major source of sickness and mortality in areas where it is endemic, as well as a major social and economic burden. The current focus of malaria control is to lower attributable morbidity and mortality. In some endemic locations, targeted chemoprophylaxis and the use of bed nets treated with pesticide have been effective. Personal safety precautions and the proper chemoprophylaxis can considerably lower the risk of infection for travellers to malaria-endemic areas. It is crucial to assess febrile travellers as away, have a high level of suspicion for malaria, make an accurate diagnosis right away, and start the proper antimalarial treatment.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74159242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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