Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00057
A. Shinde, A. Velhal, P. Jadhav, V. Redasani
Emulgel is a developing topical drug delivery technique that, if more attempt is put for the preparations with majority of topically effective drugs, will be a benefit for dermal care and cosmetic products due to its dual release control system (gel and emulsion). The direct availability of the skin as a target organ for diagnosis and treatment is a distinguishing characteristic of dermatological pharmacology. Transparent gels have grown in popularity as a crucialclass of semisolid preparations in both cosmetics and pharmaceuticals. Despite the many benefits of gels, one major limitation is the delivery of water insoluble drugs because solubility acts as a barricade and a problem arises during drug release. As a result, an emulsion-based strategy is being employed to bypass this barrier, allowing even a hydrophobic medicinal component to benefit from the special features of gels. Emulgels are dosage forms made up of gels and emulsions that have been mixed. The major goal is to generate a jellified emulsion that will reduce systemic side effects and produce a more prominent effect with fewer drug doses. Thixotropic, greaseless, good Spreadability, easily removable, soothing, soluble in water, long shelf life, bio-friendly, translucent & appealing look are only a few of the benefits of emulgels for dermatological use. As a result, emulgels can be utilize as a good topical drug delivery mechanism than the currently existing traditional systems.
{"title":"A Review on Emulgel: Improvement of Topical Absorption of Drug","authors":"A. Shinde, A. Velhal, P. Jadhav, V. Redasani","doi":"10.52711/2231-5659.2022.00057","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00057","url":null,"abstract":"Emulgel is a developing topical drug delivery technique that, if more attempt is put for the preparations with majority of topically effective drugs, will be a benefit for dermal care and cosmetic products due to its dual release control system (gel and emulsion). The direct availability of the skin as a target organ for diagnosis and treatment is a distinguishing characteristic of dermatological pharmacology. Transparent gels have grown in popularity as a crucialclass of semisolid preparations in both cosmetics and pharmaceuticals. Despite the many benefits of gels, one major limitation is the delivery of water insoluble drugs because solubility acts as a barricade and a problem arises during drug release. As a result, an emulsion-based strategy is being employed to bypass this barrier, allowing even a hydrophobic medicinal component to benefit from the special features of gels. Emulgels are dosage forms made up of gels and emulsions that have been mixed. The major goal is to generate a jellified emulsion that will reduce systemic side effects and produce a more prominent effect with fewer drug doses. Thixotropic, greaseless, good Spreadability, easily removable, soothing, soluble in water, long shelf life, bio-friendly, translucent & appealing look are only a few of the benefits of emulgels for dermatological use. As a result, emulgels can be utilize as a good topical drug delivery mechanism than the currently existing traditional systems.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76465022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00056
Sanket Nikam, Prakash A. Jadhav, B. Chaudhari, A. Velhal
Pulsatile delivery helps in providing the drug at an exact moment based on the disease's pathophysiology that cause improved patient therapeutic efficacy. Drug release rapidly after specific lag time this are advantage for many diseases condition. This system is designed according the body's circadian rhythm and after a lag time, the medication is released fast and totally as a pulse. Pulsatile delivery systems helpful in disease include asthma, arthritis, attention deficient syndrome, peptic ulcer and hypercholesterolemia. These systems are useful for diseases with chrono pharmacological behavior that necessitate nighttime administration, medications with a high first pass effect or GIT site specific absorption, and drugs with a high risk of toxicity or tolerance. By reducing dosing frequency, these devices help increase patient compliance. The foundation for this article is the disease that treat by pulsatile delivery system with drug used for specific disease condition and chrono pharmacology of all disease that mention in article.
{"title":"Pulsatile Delivery of Drug for a Range of Diseases","authors":"Sanket Nikam, Prakash A. Jadhav, B. Chaudhari, A. Velhal","doi":"10.52711/2231-5659.2022.00056","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00056","url":null,"abstract":"Pulsatile delivery helps in providing the drug at an exact moment based on the disease's pathophysiology that cause improved patient therapeutic efficacy. Drug release rapidly after specific lag time this are advantage for many diseases condition. This system is designed according the body's circadian rhythm and after a lag time, the medication is released fast and totally as a pulse. Pulsatile delivery systems helpful in disease include asthma, arthritis, attention deficient syndrome, peptic ulcer and hypercholesterolemia. These systems are useful for diseases with chrono pharmacological behavior that necessitate nighttime administration, medications with a high first pass effect or GIT site specific absorption, and drugs with a high risk of toxicity or tolerance. By reducing dosing frequency, these devices help increase patient compliance. The foundation for this article is the disease that treat by pulsatile delivery system with drug used for specific disease condition and chrono pharmacology of all disease that mention in article.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75153418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00050
R. R. Shinde, B. Chaudhari, A. Velhal, V. Redasani
In the area of solubility enhancement, several problems are encountered. Pharmacosomes are a new technology based on lipid drug carriers. Pharmacosomes are colloidal, vesicles, nanometric size micelles or a hexagonal arrangement of colloidal drug dispersions covalently attached to the phospholipid. Because of their unique properties such as active drug loading, small size, high entrapment efficiency, amphiphilicity and stability, they act as a precise drug carrier. They contribute to the controlled release of medicament at the action site, as well as the reduction of therapy cost, increased bioavailability of poorly soluble drugs, decrease toxicity and drug leakage. There has been an advancement in the scope of this delivery system for a number of drugs used for cancer, heart diseases, inflammation and protein delivery besides with a large number of herbal drugs. Pharmacosomes offer new opportunities and challenges for developing a more effective new vesicular drug delivery system.
{"title":"Pharmacosome as a Vesicular Drug Delivery System","authors":"R. R. Shinde, B. Chaudhari, A. Velhal, V. Redasani","doi":"10.52711/2231-5659.2022.00050","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00050","url":null,"abstract":"In the area of solubility enhancement, several problems are encountered. Pharmacosomes are a new technology based on lipid drug carriers. Pharmacosomes are colloidal, vesicles, nanometric size micelles or a hexagonal arrangement of colloidal drug dispersions covalently attached to the phospholipid. Because of their unique properties such as active drug loading, small size, high entrapment efficiency, amphiphilicity and stability, they act as a precise drug carrier. They contribute to the controlled release of medicament at the action site, as well as the reduction of therapy cost, increased bioavailability of poorly soluble drugs, decrease toxicity and drug leakage. There has been an advancement in the scope of this delivery system for a number of drugs used for cancer, heart diseases, inflammation and protein delivery besides with a large number of herbal drugs. Pharmacosomes offer new opportunities and challenges for developing a more effective new vesicular drug delivery system.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85742901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Any optimal medication delivery system provides a therapeutic amount of medicine to the correct spot in the body to achieve quick reaction and maintain the desired drug concentration. Intravenous drug infusion at the site of action over a desired time period can provide this optimal drug delivery. In recent years, scientists and engineers have developed rate-controlled oral medication delivery devices. These formulations provide the medicine at a controlled and predetermined rate, keeping its therapeutically effective concentration in circulation. Most restricted substances are pills. After carrying out the drug release of prepared hydrogel alginate microbeads, it was discovered that the drug release (%) was found to be in the range of 0.81 to 4.81% for the time period of 03 hours. This finding was made possible by the fact that the drug release (%) was found to be in the range of 0.81 to 4.81%. According to the data on drug release, it was discovered that the batch of fz4 had the highest sustained drug release in comparison to the other batches. According to the pattern of drug release, the rate of drug release slows down as the concentration of polymer in the formulation increases. This formulation prolongs medication release, increasing bioavailability and therapeutic activity. Sodium alginate micro beads with a release modifier could be employed as a medication carrier. The industrial-scale process needs a pilot study.
{"title":"Preparation and Evaluation of Hydrogel Alginate Beads of Rifaximin","authors":"Prasad Deshmukh, M. Tawar, Vaishnavi Chandak, Rachana Hallale, Alisha Hirani, Omkar Rajurkar","doi":"10.52711/2231-5659.2022.00049","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00049","url":null,"abstract":"Any optimal medication delivery system provides a therapeutic amount of medicine to the correct spot in the body to achieve quick reaction and maintain the desired drug concentration. Intravenous drug infusion at the site of action over a desired time period can provide this optimal drug delivery. In recent years, scientists and engineers have developed rate-controlled oral medication delivery devices. These formulations provide the medicine at a controlled and predetermined rate, keeping its therapeutically effective concentration in circulation. Most restricted substances are pills. After carrying out the drug release of prepared hydrogel alginate microbeads, it was discovered that the drug release (%) was found to be in the range of 0.81 to 4.81% for the time period of 03 hours. This finding was made possible by the fact that the drug release (%) was found to be in the range of 0.81 to 4.81%. According to the data on drug release, it was discovered that the batch of fz4 had the highest sustained drug release in comparison to the other batches. According to the pattern of drug release, the rate of drug release slows down as the concentration of polymer in the formulation increases. This formulation prolongs medication release, increasing bioavailability and therapeutic activity. Sodium alginate micro beads with a release modifier could be employed as a medication carrier. The industrial-scale process needs a pilot study.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82004329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00058
Shivani Deshmukh, B. Chaudhari, A. Velhal, V. Redasani
Polymeric nanoparticles (NPs) are tiny particles with a diameter ranging from of 1 to 1000 nm that can be loaded with active compounds or surface-adsorbed onto the polymeric core. It is novel technology by which we improved therapeutic efficacy, bioavailability of API and better patient compliance. Polymeric NPs have shown promising in the delivery of drug to specific sites for the treatment of a range of disease. Polymeric nanoparticles with a size in the nanometer range protect active substance against degradation in vitro and in vivo, release the drug in a controlled manner, and allow for targeted therapy. The current review discusses polymeric nanoparticle manufacturing methods. Using polymeric drug nanoparticles to improve the therapeutic effectiveness of poorly soluble medicines in any mode of delivery is a universal approach.
{"title":"A Review on Diverging approaches to Fabricate Polymeric Nanoparticles","authors":"Shivani Deshmukh, B. Chaudhari, A. Velhal, V. Redasani","doi":"10.52711/2231-5659.2022.00058","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00058","url":null,"abstract":"Polymeric nanoparticles (NPs) are tiny particles with a diameter ranging from of 1 to 1000 nm that can be loaded with active compounds or surface-adsorbed onto the polymeric core. It is novel technology by which we improved therapeutic efficacy, bioavailability of API and better patient compliance. Polymeric NPs have shown promising in the delivery of drug to specific sites for the treatment of a range of disease. Polymeric nanoparticles with a size in the nanometer range protect active substance against degradation in vitro and in vivo, release the drug in a controlled manner, and allow for targeted therapy. The current review discusses polymeric nanoparticle manufacturing methods. Using polymeric drug nanoparticles to improve the therapeutic effectiveness of poorly soluble medicines in any mode of delivery is a universal approach.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85000870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00045
Syed Abdul Azeez, Afreen Sultana, Amtul Hajera
Sodium alginate (SA)-based β-cyclodextrin(β-CD) can show an amazing adsorption capacity and are considered as secure and biocompatible frameworks for evacuating harmful particles from the body. Tyrosine, an amino acid which is found in certain nourishment and food constituents is changed over into p-Cresyl sulfate by intestine microbiota and on the off chance that this cannot be evacuated from the body, it will come-up as a dangerous uremic toxin in the body and rapid removal of this toxic molecule is relevant especially for patients affected by chronic kidney disease. Based on the necessity in the removal of this protein bound uremic toxin, Innovative cyclodextrin polymers were synthesized with different concentrations of sodium alginate to form nanosponges which are able to remove p-Cresol (Phenolic molecule), before it converted into the toxic form i,e,. p-Cresyl sulfate in the body. Furthermore, in vitro studies were carried out using optimal concentrations of sodium alginate with β-cyclodextrin-NS formulations by assessing physicochemical properties, stability, phenol adsorption capacity and in vitro toxicity. Nanosponges (NSs) were found to be of 1:2 proportion of β-cyclodextrin with sodium alginate respectively as NS2-formulation with an adsorption efficiency of in-vitro phenol toxin is 72%. In contrast, this subsidiary was more-steady in gastrointestinal media. In conclusion, this idea proposes that CD-NS details are secure and successful in expelling harmful atoms from the body. Their potential utilization in veterinary or human medication may diminish dialysis recurrence and lead to decreased phenol arrangement which concurrently decreases the cardiovascular and renal burden.
{"title":"β-Cyclodextrin with Sodium Alginate based Nanosponges Preparation and Characterization in the Removal of Organic Toxin: p-Cresol in the Simulated Biological Fluids","authors":"Syed Abdul Azeez, Afreen Sultana, Amtul Hajera","doi":"10.52711/2231-5659.2022.00045","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00045","url":null,"abstract":"Sodium alginate (SA)-based β-cyclodextrin(β-CD) can show an amazing adsorption capacity and are considered as secure and biocompatible frameworks for evacuating harmful particles from the body. Tyrosine, an amino acid which is found in certain nourishment and food constituents is changed over into p-Cresyl sulfate by intestine microbiota and on the off chance that this cannot be evacuated from the body, it will come-up as a dangerous uremic toxin in the body and rapid removal of this toxic molecule is relevant especially for patients affected by chronic kidney disease. Based on the necessity in the removal of this protein bound uremic toxin, Innovative cyclodextrin polymers were synthesized with different concentrations of sodium alginate to form nanosponges which are able to remove p-Cresol (Phenolic molecule), before it converted into the toxic form i,e,. p-Cresyl sulfate in the body. Furthermore, in vitro studies were carried out using optimal concentrations of sodium alginate with β-cyclodextrin-NS formulations by assessing physicochemical properties, stability, phenol adsorption capacity and in vitro toxicity. Nanosponges (NSs) were found to be of 1:2 proportion of β-cyclodextrin with sodium alginate respectively as NS2-formulation with an adsorption efficiency of in-vitro phenol toxin is 72%. In contrast, this subsidiary was more-steady in gastrointestinal media. In conclusion, this idea proposes that CD-NS details are secure and successful in expelling harmful atoms from the body. Their potential utilization in veterinary or human medication may diminish dialysis recurrence and lead to decreased phenol arrangement which concurrently decreases the cardiovascular and renal burden.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79976933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00047
T. Jain, A. Vyas, D. Dubey, K. Dashora, Vishal Jain
Eladi gutika is official in Ayurvedic formulary of India and used as a remedy for Kasa (Cough), Svasa (Asthma), Bhrama (Vertigo), Raktapitta (Bleeding disorders), Jvara (Fever), Amvata (Rheumatism) etc. The present paper is an effort to develop the routine fingerprinting method for quality control parameter of Eladi gutika by high performance thin layer chromatography using glycyrrhizinic acid as an internal standard. The HPTLC estimation was carried out with three laboratory batches and one marketed formulation Eladi gutika and crude drug containing glycyrrhizinic acid. The concentration of glycyrrhizinic acid present in raw material was found to be 8.2201±0.497w/w in G. glabra and in three identical laboratory batch of Eladi gutika EG-I, EG -II and EG -III, was found to be 1.4945 ± 0.293, 1.4963 ± 0.763%, 1.4944± 0.864w/w respectively. The glycyrrhizinic acid content in all the three different batches is found to be in close proximities with each other. The results were comparable to marketed formulations. Hence the present method is simple, sensitive, precise and accurate and can be adopted for routine fingerprinting method for quality control of Eladi gutika.
{"title":"Development of Fingerprinting Method for Estimation Glycyrrhizinic acid in Ayurvedic formulation Eladi Gutika: A HPTLC approach","authors":"T. Jain, A. Vyas, D. Dubey, K. Dashora, Vishal Jain","doi":"10.52711/2231-5659.2022.00047","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00047","url":null,"abstract":"Eladi gutika is official in Ayurvedic formulary of India and used as a remedy for Kasa (Cough), Svasa (Asthma), Bhrama (Vertigo), Raktapitta (Bleeding disorders), Jvara (Fever), Amvata (Rheumatism) etc. The present paper is an effort to develop the routine fingerprinting method for quality control parameter of Eladi gutika by high performance thin layer chromatography using glycyrrhizinic acid as an internal standard. The HPTLC estimation was carried out with three laboratory batches and one marketed formulation Eladi gutika and crude drug containing glycyrrhizinic acid. The concentration of glycyrrhizinic acid present in raw material was found to be 8.2201±0.497w/w in G. glabra and in three identical laboratory batch of Eladi gutika EG-I, EG -II and EG -III, was found to be 1.4945 ± 0.293, 1.4963 ± 0.763%, 1.4944± 0.864w/w respectively. The glycyrrhizinic acid content in all the three different batches is found to be in close proximities with each other. The results were comparable to marketed formulations. Hence the present method is simple, sensitive, precise and accurate and can be adopted for routine fingerprinting method for quality control of Eladi gutika.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81945018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00052
A. V. Panval, B. Chaudhari, A. Velhal, V. Redasani
Transdermal Drug Delivery Systems comes under the category of Controlled drug delivery. The main goal of TDDS is to deliver the drug through skin into systemic circulation at controlled rate. TDDS is used to overcome the problems faced during drug administration through oral route. TDDS offers various advantages over different types of drug delivery like oral, IV etc. it provides control release of drug, avoids first pass metabolism, improves bioavailability, better patient compliance and many more. Drug with small molecules can be easily given by transdermal route. These Transdermal patches represents key outcome for growth in skin science and technology. This Review article explains all the detailed information of introduction of TDDS, its advantages and disadvantages, skin and drug permeation and its principle, contents of Transdermal patches it's types and evaluation test.
{"title":"A Novel Tool for Controlled Delivery: Transdermal Drug Delivery System","authors":"A. V. Panval, B. Chaudhari, A. Velhal, V. Redasani","doi":"10.52711/2231-5659.2022.00052","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00052","url":null,"abstract":"Transdermal Drug Delivery Systems comes under the category of Controlled drug delivery. The main goal of TDDS is to deliver the drug through skin into systemic circulation at controlled rate. TDDS is used to overcome the problems faced during drug administration through oral route. TDDS offers various advantages over different types of drug delivery like oral, IV etc. it provides control release of drug, avoids first pass metabolism, improves bioavailability, better patient compliance and many more. Drug with small molecules can be easily given by transdermal route. These Transdermal patches represents key outcome for growth in skin science and technology. This Review article explains all the detailed information of introduction of TDDS, its advantages and disadvantages, skin and drug permeation and its principle, contents of Transdermal patches it's types and evaluation test.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78109308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00046
Varalakshmi Avula, S. P, S. B., K. M
Milk contains whole nutrients and is consumed by the majority of population in the form of drinking as well as dietary products. Milk adulteration is one of the most common phenomena, this milk adulteration can be over looked in many countries. it shows serious health hazards leading to fatal diseases. Milk adulterants have been reported globally by adding various instances such as adding water, whey proteins, melamine, urea, detergents, starch hydrogen peroxide, boric acid. This paper presents a detailed review of common milk adulterants as well as different methods such as the chromatographic methods such as HPLC and GC coupled with mass spectrometry to detect the adulterants in milk, and immunological techniques such as ELISA and various DNA based procedures like PCR have also been used to detect the adulterants both qualitatively and quantitatively. This study is organized to be an adulterants-based study instead of a techniques-based one, where qualitative detection for most of the common adulterants are enlisted and quantitative detection methods are limited to a few major adulterants of milk. Apart from regular techniques, recent development in these detection techniques has also been reported. Nowadays milk is being adulterated in more sophisticated ways that demand for cutting- edge research for the detection of adulterants. This review intends to contribute towards the common knowledge base regarding possible milk adulterants and their detection techniques.
{"title":"Analytical methods to detect the Adulterants in Milk - An Overview","authors":"Varalakshmi Avula, S. P, S. B., K. M","doi":"10.52711/2231-5659.2022.00046","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00046","url":null,"abstract":"Milk contains whole nutrients and is consumed by the majority of population in the form of drinking as well as dietary products. Milk adulteration is one of the most common phenomena, this milk adulteration can be over looked in many countries. it shows serious health hazards leading to fatal diseases. Milk adulterants have been reported globally by adding various instances such as adding water, whey proteins, melamine, urea, detergents, starch hydrogen peroxide, boric acid. This paper presents a detailed review of common milk adulterants as well as different methods such as the chromatographic methods such as HPLC and GC coupled with mass spectrometry to detect the adulterants in milk, and immunological techniques such as ELISA and various DNA based procedures like PCR have also been used to detect the adulterants both qualitatively and quantitatively. This study is organized to be an adulterants-based study instead of a techniques-based one, where qualitative detection for most of the common adulterants are enlisted and quantitative detection methods are limited to a few major adulterants of milk. Apart from regular techniques, recent development in these detection techniques has also been reported. Nowadays milk is being adulterated in more sophisticated ways that demand for cutting- edge research for the detection of adulterants. This review intends to contribute towards the common knowledge base regarding possible milk adulterants and their detection techniques.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81167912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5659.2022.00054
Bhagyashri V. Aiwale, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani
The ‘in situ gel’ system has appeared as one of the most effective drug delivery systems. Its specific distinguishing feature of 'Sol to Gel' transition aids in the continuous and controlled release of medicines. These systems have a number of advantages, including simple production, convenience of use, enhanced adherence, and patient comfort by lowering drug delivery frequency due to their distinctive sol to gel transition characteristics. An in-situ gelling system is a formulation that is in solution form before penetrating the body but transforms to gel form under specified physiological conditions. This review mainly focused on introduction, Advantages and Disadvantages of in situ gel, mechanism, types of Polymers used, Evaluation of in situ gel and its applications.
{"title":"A Review on in situ Gel of Gastro Retentive Drug Delivery System","authors":"Bhagyashri V. Aiwale, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani","doi":"10.52711/2231-5659.2022.00054","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00054","url":null,"abstract":"The ‘in situ gel’ system has appeared as one of the most effective drug delivery systems. Its specific distinguishing feature of 'Sol to Gel' transition aids in the continuous and controlled release of medicines. These systems have a number of advantages, including simple production, convenience of use, enhanced adherence, and patient comfort by lowering drug delivery frequency due to their distinctive sol to gel transition characteristics. An in-situ gelling system is a formulation that is in solution form before penetrating the body but transforms to gel form under specified physiological conditions. This review mainly focused on introduction, Advantages and Disadvantages of in situ gel, mechanism, types of Polymers used, Evaluation of in situ gel and its applications.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72625783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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