Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00038
S. Bhamburkar, Shubham Khandare, S. Patharkar, Saurabh Thakare
Thiocolchicoside is a most common used muscle relaxant in the case of treating acute painful muscle spasms. It has a selective affinity for the inhibitory gamma-amino butyric acid and glycinergic receptors, although, the proper pathway of the muscle relaxation is unknown till the date. This drug should be strictly prohibited in the patients causing seizures. The recent studies done by the European medicines agency says that it causes aneuploidy which leads to use of the drug for limited time period which was earlier considered safe. Aneuploidy is a common chromosome disorder occurring in the humans, which leads to genetic cause of miscarriage, congenital birth defects and reduced fertility in men. During pregnancy, in breastfeeding and in children below 16 years, Thiocolchicoside is contraindicated.
{"title":"Thiocolchicoside: An Updated Review","authors":"S. Bhamburkar, Shubham Khandare, S. Patharkar, Saurabh Thakare","doi":"10.52711/2231-5659.2022.00038","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00038","url":null,"abstract":"Thiocolchicoside is a most common used muscle relaxant in the case of treating acute painful muscle spasms. It has a selective affinity for the inhibitory gamma-amino butyric acid and glycinergic receptors, although, the proper pathway of the muscle relaxation is unknown till the date. This drug should be strictly prohibited in the patients causing seizures. The recent studies done by the European medicines agency says that it causes aneuploidy which leads to use of the drug for limited time period which was earlier considered safe. Aneuploidy is a common chromosome disorder occurring in the humans, which leads to genetic cause of miscarriage, congenital birth defects and reduced fertility in men. During pregnancy, in breastfeeding and in children below 16 years, Thiocolchicoside is contraindicated.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82509583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
According to WHO, Pharmacovigilance (PV) is characterized as the science and exercises identifying with the recognition, appraisal, comprehension and anticipation of unfavourable impacts or some other medication related issue. It is an important part of our medication guideline framework. As we know, India is the world's second most populated country with very nearly one billion dynamic and potential medication buyers and clients. Though our country is participating in Uppsala Monitoring Centre, its obligation to that data base is by and pretty much nothing. This issue is due to the lack of proper ADR (Adverse drug reaction) monitoring system and awareness among associates of medicines and health workers. PV program mainly aims for patient care, patient safety and monitoring of adverse drug reaction. For the accurate practice of PV in India, there are need of more clinical preliminaries and clinical examinations. For the safe and sensible use of medication, a perfectly working PV system is mandatory. PV will be invaluable in India not only for medical services experts, regulatory authorities, pharmaceutical organizations but also for the consumers to screen the medicines. This article gives a methodical audit of the pharmacovigilance program in India (PvPI) from its starting point to the current situation and furthermore examines the future parts of pharmacovigilance program in India.
{"title":"Pharmacovigilance programme in India (PvPI): History, Current scenario, future aspects and role in COVID 19","authors":"Sangeet Kumar Mall, Priti Dipa, Shambaditya Goswami, Prashant Singh, Ravindra Pal Singh","doi":"10.52711/2231-5659.2022.00036","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00036","url":null,"abstract":"According to WHO, Pharmacovigilance (PV) is characterized as the science and exercises identifying with the recognition, appraisal, comprehension and anticipation of unfavourable impacts or some other medication related issue. It is an important part of our medication guideline framework. As we know, India is the world's second most populated country with very nearly one billion dynamic and potential medication buyers and clients. Though our country is participating in Uppsala Monitoring Centre, its obligation to that data base is by and pretty much nothing. This issue is due to the lack of proper ADR (Adverse drug reaction) monitoring system and awareness among associates of medicines and health workers. PV program mainly aims for patient care, patient safety and monitoring of adverse drug reaction. For the accurate practice of PV in India, there are need of more clinical preliminaries and clinical examinations. For the safe and sensible use of medication, a perfectly working PV system is mandatory. PV will be invaluable in India not only for medical services experts, regulatory authorities, pharmaceutical organizations but also for the consumers to screen the medicines. This article gives a methodical audit of the pharmacovigilance program in India (PvPI) from its starting point to the current situation and furthermore examines the future parts of pharmacovigilance program in India.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85440954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00041
M. H. Markad, S. Mankar
About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.
{"title":"Review on: Solubility Enhancement of Poorly Water Soluble Drugs","authors":"M. H. Markad, S. Mankar","doi":"10.52711/2231-5659.2022.00041","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00041","url":null,"abstract":"About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76199929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00035
N. Sreeharsha, Mazen Al Gharsan
The microneedling technique was initially introduced for skin rejuvenation in cosmetology. The technique is minimally invasive and therefore explored for the treatment of multiple dermatological conditions. High effectiveness, very less side effects and quick recovery time are the benefits of skin microneedling as a cosmetic, and medical treatment. Over the last two decades, the applications of microneedling in skin science have grown drastically. The technique is effective in the treatment of acne scar, vitiligo, alopecia, melasma, and skin cancer. The current review focuses on the cosmetic as well as therapeutic applications of microneedling for the treatment of various skin problems.
{"title":"Therapeutics of microneedling for skin repair","authors":"N. Sreeharsha, Mazen Al Gharsan","doi":"10.52711/2231-5659.2022.00035","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00035","url":null,"abstract":"The microneedling technique was initially introduced for skin rejuvenation in cosmetology. The technique is minimally invasive and therefore explored for the treatment of multiple dermatological conditions. High effectiveness, very less side effects and quick recovery time are the benefits of skin microneedling as a cosmetic, and medical treatment. Over the last two decades, the applications of microneedling in skin science have grown drastically. The technique is effective in the treatment of acne scar, vitiligo, alopecia, melasma, and skin cancer. The current review focuses on the cosmetic as well as therapeutic applications of microneedling for the treatment of various skin problems.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74480765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00029
Tariq Ahmad Khan, Rajesh Singh Pawar, Hargovind Garg
The present study was performed to evaluate the hepatoprotective activity of ployherbal preparation of livina against ethanol-induced hepatotoxicity in rats. Four groups of adult albino wistar rats were taken for the study. Rats were divided into four groups each containing 6 animals. Group first is normal group received the normal saline 10ml/kg for 21th days. Group second negative control this group received ethanol 12ml/kg bw per day is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Group third is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Silymarin and ethanol is administered orally. Fourth group is treated with ethanol + livina (Herbal capsule). The level of Serum Glutamic Pyruvic Transaminase Test (SGPT), Serum Glutamic-Oxaloacetic Transaminase Test (SGOT), alkaline phosphatase (ALP) and total bilirubin were determined to assay hepatotoxicity. Ethanol administration caused severe hepatic damage in rats as evidenced by elevated serum SGPT, SGOT, ALP and total bilirubin levels. The polyherbal preparation of livina and silymarin administration prevented the toxic effect of ethanol. The present study concludes polyherbal preparation of livina that has significant hepatoprotective activity against ethanol induced hepatotoxicity, which may be associated with its bioactive component.
{"title":"Evaluation of Polyherbal preparation of Livina against Ethanol Induced Liver Dysfunction","authors":"Tariq Ahmad Khan, Rajesh Singh Pawar, Hargovind Garg","doi":"10.52711/2231-5659.2022.00029","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00029","url":null,"abstract":"The present study was performed to evaluate the hepatoprotective activity of ployherbal preparation of livina against ethanol-induced hepatotoxicity in rats. Four groups of adult albino wistar rats were taken for the study. Rats were divided into four groups each containing 6 animals. Group first is normal group received the normal saline 10ml/kg for 21th days. Group second negative control this group received ethanol 12ml/kg bw per day is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Group third is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Silymarin and ethanol is administered orally. Fourth group is treated with ethanol + livina (Herbal capsule). The level of Serum Glutamic Pyruvic Transaminase Test (SGPT), Serum Glutamic-Oxaloacetic Transaminase Test (SGOT), alkaline phosphatase (ALP) and total bilirubin were determined to assay hepatotoxicity. Ethanol administration caused severe hepatic damage in rats as evidenced by elevated serum SGPT, SGOT, ALP and total bilirubin levels. The polyherbal preparation of livina and silymarin administration prevented the toxic effect of ethanol. The present study concludes polyherbal preparation of livina that has significant hepatoprotective activity against ethanol induced hepatotoxicity, which may be associated with its bioactive component.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88165755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoemulsions are colloidal emulsions made up of two immiscible liquids, one of which is scattered and the other continuous. Nanoemulsions are two types W/O and O/W. Nanoemulsion are size varies from 20 to 200nm. Nanoemulsions are thermodynamically stable. Emulsifiers are stabilised nanoemulsion. There are two types of emulsifiers: one is hydrophilic and the other is lipophilic. Nanoemulsion is widely used in food industry, beverages, agriculture, bio-pharmaceutical, dairy products. Nanoemulsion widely prepared by using high energy or brute force comprising ultra sonication and ultra high pressure homogenizer and low energy or persuasion method compressing both phase inversion composition (PIC) and the phase inversion temperature (PIT). Newly a developed method used as preparation of nanoemulsion bubble bursting, micro- fluidization and evaporative ripening. The aim of review a article focusing on to preparation method characterization application of nanoemulsion.
{"title":"A Overview on Nanoemulsion","authors":"Doiphode Ankush R, Patwekar S. L., Guhade Namdev, Vaishnavi Gole, Ashwini Rode, Suleman Shaikh","doi":"10.52711/2231-5659.2022.00042","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00042","url":null,"abstract":"Nanoemulsions are colloidal emulsions made up of two immiscible liquids, one of which is scattered and the other continuous. Nanoemulsions are two types W/O and O/W. Nanoemulsion are size varies from 20 to 200nm. Nanoemulsions are thermodynamically stable. Emulsifiers are stabilised nanoemulsion. There are two types of emulsifiers: one is hydrophilic and the other is lipophilic. Nanoemulsion is widely used in food industry, beverages, agriculture, bio-pharmaceutical, dairy products. Nanoemulsion widely prepared by using high energy or brute force comprising ultra sonication and ultra high pressure homogenizer and low energy or persuasion method compressing both phase inversion composition (PIC) and the phase inversion temperature (PIT). Newly a developed method used as preparation of nanoemulsion bubble bursting, micro- fluidization and evaporative ripening. The aim of review a article focusing on to preparation method characterization application of nanoemulsion.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76384749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00039
Omkar A. Devade, Rohan D. Londhe, Nisarga V. Sokate, Utkarsha R. Randave, Pallavi A. Ranpise
Polycystic ovary disorder (PCOD) is hormonal disorder among reproductive-age women. Causing enlarged ovaries with small cysts on the outer edges in patients with PCOD, the secretion rate and metabolism of androgens and estrogens are disrupted. The pathophysiology of the syndrome is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factor. With regards to the increasing prevalence of PCOD and associated mental and physical problemsas well as the effects of changes in sex hormones in development of this disease, our aim is to investigate the effects of synthetic drug and herbal drug in the serum levels of sex hormones and ovarian tissue. Several Pharmacological studies have described the use of various Ayurvedic medicinal plants and their constituents play the important role for the treatment of PCOD.Therefore, this drug can be partly effective in this syndrome via affecting the different hormones and serum levels of ovarian morphology, weight and representing an opportunity to investigate and discovery new bioactive products. This review discussed some synthetic and herbal drug which has the potential for the treatment of PCOD.
{"title":"A Review on: Polycystic Ovarian Disorder","authors":"Omkar A. Devade, Rohan D. Londhe, Nisarga V. Sokate, Utkarsha R. Randave, Pallavi A. Ranpise","doi":"10.52711/2231-5659.2022.00039","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00039","url":null,"abstract":"Polycystic ovary disorder (PCOD) is hormonal disorder among reproductive-age women. Causing enlarged ovaries with small cysts on the outer edges in patients with PCOD, the secretion rate and metabolism of androgens and estrogens are disrupted. The pathophysiology of the syndrome is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factor. With regards to the increasing prevalence of PCOD and associated mental and physical problemsas well as the effects of changes in sex hormones in development of this disease, our aim is to investigate the effects of synthetic drug and herbal drug in the serum levels of sex hormones and ovarian tissue. Several Pharmacological studies have described the use of various Ayurvedic medicinal plants and their constituents play the important role for the treatment of PCOD.Therefore, this drug can be partly effective in this syndrome via affecting the different hormones and serum levels of ovarian morphology, weight and representing an opportunity to investigate and discovery new bioactive products. This review discussed some synthetic and herbal drug which has the potential for the treatment of PCOD.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90842430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00033
Kamalakshi Krishnamurthy, T. Zin., K. Priyamvatha, Mahadeva Rao U.S., S. M.
Drug abuse has become more prevalent in India. Smokers mix Ganja (marijuana) along with tobacco in the cigarettes or cigars. Necessity has arisen at this juncture to separately locate Ganja in the admixture of Tobacco and Ganja. The present work envisages a new developing as well as identification method for separating Ganja from Tobacco by Thin Layer chromatography simultaneously in the same plate.
{"title":"Detection of Ganja and Nicotine Admixture by a New System","authors":"Kamalakshi Krishnamurthy, T. Zin., K. Priyamvatha, Mahadeva Rao U.S., S. M.","doi":"10.52711/2231-5659.2022.00033","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00033","url":null,"abstract":"Drug abuse has become more prevalent in India. Smokers mix Ganja (marijuana) along with tobacco in the cigarettes or cigars. Necessity has arisen at this juncture to separately locate Ganja in the admixture of Tobacco and Ganja. The present work envisages a new developing as well as identification method for separating Ganja from Tobacco by Thin Layer chromatography simultaneously in the same plate.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84951318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00032
Adarsh Kumar Pathak, Akhilesh Gupta
Amoxycillin (AMX) and Potassium clavulanate (PTC) are proven for their therapeutic benefits to treats various diseases. AMX and PTC are proven for their therapeutic benefits to treat various diseases. Due to their synergistic actions, a rapid and specific RP-HPLC method was processed and validated as per ICH guidelines. The chromatographic separation was performed with Inertsil 5μ, 250 mm X 4.6 mm, C-18 HPLC column by using phosphate buffer: methanol (80:20) as mobile phase, at 1mL/min of flow rate and 220nm m. The absorption maxima were found to be 246.6 nm for AMX and 257.6 nm for PTC in 0.1M NaOH used as the solvent. The linearity for these drugs at the selected wavelengths lies between 5-200 µg/ml for AMX and 5-200 µg/ml for PTC. Accuracy was determined by recovery study from injection dosages forms were found to be 99.352 for AMX and 99.533 for PTC. Precision of method was determined as repeatability, day to day and analyst to analyst variation and a show the value within acceptable limit i.e. R.S.D was found to be less than 2 percent).
阿莫西林(AMX)和克拉维酸钾(PTC)被证明具有治疗各种疾病的疗效。AMX和PTC治疗多种疾病的疗效已被证实。由于它们的协同作用，根据ICH指南，建立了一种快速、特异的反相高效液相色谱方法。色谱柱为Inertsil 5μ， 250 mm × 4.6 mm, C-18高效液相色谱柱，流动相为磷酸缓冲液:甲醇(80:20)，流速为1mL/min，流速为220nm m，以0.1M NaOH为溶剂，AMX和PTC的最大吸光度分别为246.6 nm和257.6 nm。在所选波长下，这些药物的线性关系在AMX的5-200µg/ml和PTC的5-200µg/ml之间。通过对注射剂型的回收率研究确定了准确度，发现AMX的回收率为99.352,PTC的回收率为99.533。方法的精度被确定为可重复性，每天和分析师对分析师的变化，并显示在可接受范围内的值，即rsd被发现小于2%)。
{"title":"Simultaneous Estimation of Amoxycillin and Potassium Clavulanate in Injection Formulation by RP-HPLC","authors":"Adarsh Kumar Pathak, Akhilesh Gupta","doi":"10.52711/2231-5659.2022.00032","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00032","url":null,"abstract":"Amoxycillin (AMX) and Potassium clavulanate (PTC) are proven for their therapeutic benefits to treats various diseases. AMX and PTC are proven for their therapeutic benefits to treat various diseases. Due to their synergistic actions, a rapid and specific RP-HPLC method was processed and validated as per ICH guidelines. The chromatographic separation was performed with Inertsil 5μ, 250 mm X 4.6 mm, C-18 HPLC column by using phosphate buffer: methanol (80:20) as mobile phase, at 1mL/min of flow rate and 220nm m. The absorption maxima were found to be 246.6 nm for AMX and 257.6 nm for PTC in 0.1M NaOH used as the solvent. The linearity for these drugs at the selected wavelengths lies between 5-200 µg/ml for AMX and 5-200 µg/ml for PTC. Accuracy was determined by recovery study from injection dosages forms were found to be 99.352 for AMX and 99.533 for PTC. Precision of method was determined as repeatability, day to day and analyst to analyst variation and a show the value within acceptable limit i.e. R.S.D was found to be less than 2 percent).","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82965084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5659.2022.00043
R. Kumar
The discovery of a new drug started with drug’s compounds derived from natural sources (animals, plants, microorganisms or marine sources) or compounds are synthesized in the laboratory. The Researchers insight into a disease process and design a product to stop or reverse the effects of the disease. Now study the Existing treatments followed by new technologies make drug to target specific sites. Once researchers identify a promising compound then a series of experiments conducted. How it is absorbed, distributed, metabolized and excreted, best dose, best way to deliver, side effects, effectiveness and mechanism of action.
{"title":"Discovery of a new Drug: A Fundamental Review","authors":"R. Kumar","doi":"10.52711/2231-5659.2022.00043","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00043","url":null,"abstract":"The discovery of a new drug started with drug’s compounds derived from natural sources (animals, plants, microorganisms or marine sources) or compounds are synthesized in the laboratory. The Researchers insight into a disease process and design a product to stop or reverse the effects of the disease. Now study the Existing treatments followed by new technologies make drug to target specific sites. Once researchers identify a promising compound then a series of experiments conducted. How it is absorbed, distributed, metabolized and excreted, best dose, best way to deliver, side effects, effectiveness and mechanism of action.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83782997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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