Asian journal of psychiatry最新文献

英文中文

The reliability of medication and death recording in electronic health records among people with schizophrenia in Hong Kong 香港精神分裂症患者电子健康记录中用药和死亡记录的可靠性

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-19 DOI: 10.1016/j.ajp.2024.104315

Huiquan Zhou , Jennifer Yee Man Tang , Sherry Kit Wa Chan , Hao Luo

Objective

This study aimed to examine the reliability of death and medication records among individuals diagnosed with schizophrenia between two widely-used electronic health record (EHR) databases in Hong Kong: the Clinical Management System (CMS) and the Clinical Data Analysis and Reporting System (CDARS).

Methods

A cohort of patients with schizophrenia-spectrum disorders enrolled in public psychiatric services in Hong Kong between 1998 and 2003 was identified from the CMS. The unique IDs, vital status, and clozapine prescription information of these patients were extracted from both the CMS and CDARS. The positive predictive value (PPV) was computed to evaluate the concordance of records between the two databases.

Results

Of the 1234 patients identified in the CMS, 1119 (90.7 %) had a record of schizophrenia in the CDARS. All deaths recorded in the CDARS matched those in the CMS, but the PPV for the exact date of death was 66.4 %, improving to 86.0 % when allowing a 30-day margin of error. The PPV for clozapine prescribing was 96.1 %, and 91.8 % for the initiation date when allowing a 30-day margin of error.

Conclusion

This study provides evidence on the reliability of mortality and medication data for patients with schizophrenia in two widely-used EHR databases in Hong Kong. While the record on whether an event has occurred had excellent concordance, the exact timing of events showed lower reliability, highlighting the need to consider data resolution when utilizing these databases for research.

本研究旨在检测香港两个广泛使用的电子病历数据库：临床管理系统（CMS）和临床数据分析与报告系统（CDARS）之间被诊断为精神分裂症患者的死亡和用药记录的可靠性。从 CMS 和 CDARS 中提取了这些患者的唯一 ID、生命状态和氯氮平处方信息。结果在CMS系统中确认的1234名患者中，有1119名（90.7%）在CDARS系统中有精神分裂症记录。CDARS 中记录的所有死亡病例均与 CMS 中的病例相符，但准确死亡日期的 PPV 为 66.4%，如果允许 30 天的误差范围，则 PPV 提高到 86.0%。在允许30天误差的情况下，氯氮平处方的PPV为96.1%，开始用药日期的PPV为91.8%。结论本研究为香港两个广泛使用的电子病历数据库中精神分裂症患者的死亡率和用药数据的可靠性提供了证据。虽然事件是否发生的记录具有很好的一致性，但事件发生的确切时间却显示出较低的可靠性，这突出表明在利用这些数据库进行研究时需要考虑数据分辨率。

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引用次数: 0

The Asian Journal of Psychiatry turns sweet sixteen: An end of year review 亚洲精神病学杂志》迎来十六岁生日：年终回顾。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-19 DOI: 10.1016/j.ajp.2024.104323

Rajiv Tandon

引用次数: 0

Premorbid autistic traits in phenocopy syndrome of behavioral variant frontotemporal dementia: An autopsy revealing primary age-related tauopathy 行为变异型额颞叶痴呆表型综合征的病前自闭症特征：通过尸检发现原发性年龄相关陶土病

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-18 DOI: 10.1016/j.ajp.2024.104314

Shusei Arafuka, Youta Torii, Hiroshige Fujishiro , Hirotaka Sekiguchi, Ayako Miwa, Chikako Habuchi, Kazumi Sasada, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda

引用次数: 0

Enduring conflict: The effects of war trauma on the well-being of Palestinian children 持久的冲突：战争创伤对巴勒斯坦儿童福祉的影响。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-08 DOI: 10.1016/j.ajp.2024.104304

Amani N. Alansari

引用次数: 0

Altered resting-state brain activity of the superior parietal cortex and striatum in major depressive disorder and schizophrenia 重度抑郁障碍和精神分裂症患者的上顶叶皮层和纹状体静息态大脑活动改变。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104303

Cheng Chen , Baoli Zhang , Xucong Qin , Huan Huang , Bei Rong , Huiling Wang , Liang Zhang , Wei Yuan

Background

Resting-state functional magnetic resonance imaging (fMRI) studies have shown altered brain activity in major depressive disorder (MDD) and schizophrenia (SZ). Despite differing diagnoses, SZ and MDD share similar features. However, functional brain activity similarities and differences between SZ and MDD remain unclear.

Methods

Participants with MDD, SZ, and normal controls (n=36 each) underwent resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFF) was used to analyze the preprocessed rs-fMRI data. One-way ANOVAs and post hoc analyses compared ALFF values in different brain regions. Pearson correlation analysis examined associations with clinical symptoms.

Results

Comparison among the three groups revealed significant differences in ALFF values within the left superior parietal cortex (L-SPC) and bilateral striatum. Through pairwise comparisons, patients with SZ but not patients with MDD were found to exhibit increased striatum ALFF values relative to NC individuals, but decreased in MDD. Meanwhile, L-SPC ALFF values were significantly increased in patients with SZ relative to both normal control individuals and patients with MDD, while no differences in these values were observed between the normal control and MDD groups. The Pearson correlation analyses showed significant positive correlations between ALFF in the striatum and PANSS positive score, but no significant correlation with other symptom severity in SZ and MDD.

Conclusion

These findings support the hypothesis of alterations in brain functional activity as a fundamental component of the pathogenesis of MDD and SZ. The observed differences in functional brain activity in the superior parietal cortex and striatum between MDD and SZ provide a neuroimaging basis that can contribute to the differential diagnosis of these debilitating conditions.

背景：静息态功能磁共振成像（fMRI）研究显示，重度抑郁症（MDD）和精神分裂症（SZ）患者的大脑活动发生了改变。尽管诊断方法不同，但 SZ 和 MDD 具有相似的特征。然而，SZ 和 MDD 之间大脑功能活动的异同仍不清楚：方法：对患有 MDD、SZ 和正常对照组的参与者（各 36 人）进行静息态 fMRI 扫描。低频波动幅度（ALFF）用于分析预处理后的rs-fMRI数据。单因素方差分析和事后分析比较了不同脑区的 ALFF 值。皮尔逊相关分析检验了与临床症状的关联：三组患者的比较结果显示，左上顶叶皮层（L-SPC）和双侧纹状体的 ALFF 值存在显著差异。通过配对比较发现，相对于NC患者，SZ患者（而非MDD患者）的纹状体ALFF值升高，但MDD患者的ALFF值降低。同时，与正常对照组和 MDD 患者相比，SZ 患者的 L-SPC ALFF 值明显升高，而正常对照组和 MDD 组之间的 ALFF 值没有差异。皮尔逊相关分析表明，纹状体中的 ALFF 与 PANSS 阳性评分呈显著正相关，但与 SZ 和 MDD 的其他症状严重程度无显著相关：这些研究结果支持大脑功能活动的改变是 MDD 和 SZ 发病机制的基本组成部分这一假设。在顶叶上皮层和纹状体中观察到的 MDD 和 SZ 的大脑功能活动差异提供了一个神经影像学基础，有助于这些衰弱性疾病的鉴别诊断。

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引用次数: 0

Modulating neuroplasticity through synergistic ketamine and accelerated sequential theta burst stimulation (TBS) for treatment-resistant depression (TRD) – A case report 通过氯胺酮和加速序列θ爆发刺激（TBS）的协同作用调节神经可塑性，治疗耐药抑郁症（TRD）--病例报告

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104302

Veena Ramesh, Varsha Shamanna, Harsh Pathak, Swarna Buddha Nayok, Anushree Bose, Vanteemar S. Sreeraj, Ganesan Venkatasubramanian

引用次数: 0

Severe suicide attempts, day of the week, and holidays in South Korea: A nationwide case time series study 韩国的严重自杀企图、星期和节假日：全国病例时间序列研究。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104299

Harin Min , Jiwoo Park , Hyewon Yoon, Jieun Oh, Sojin Ahn, Cinoo Kang, Whanhee Lee

引用次数: 0

Reliability and validity study of the Turkish version of the Schizophrenia Cognition Rating Scale (SCoRS-TR) 土耳其版精神分裂症认知评定量表（SCoRS-TR）的可靠性和有效性研究。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104301

Nedim Özak , Emine Ilgın Hoşgelen , Berna Binnur Akdede , Köksal Alptekin

Background

Schizophrenia is characterized by significant dysfunction in cognitive domains. Despite its crucial role in prognosis, evaluating neurocognitive impairments is challenging in outpatient settings because of the time-consuming nature of neurocognitive assessments. SCoRS “Schizophrenia Cognition Rating Scale” is a scale that provides brief cognitive evaluation. This study aimed to establish the validity and reliability of the Turkish version of the “Schizophrenia Cognition Rating Scale” (SCoRS-TR) in patients with schizophrenia and examine the correlation between SCoRS and cognitive tests.

Methods

Data were collected from 130 patients with schizophrenia who met the DSM-5 criteria and 40 healthy controls. SCoRS rating, Positive and Negative Syndrome Scale (PANSS), and a neurocognitive test battery were administered.

Results

Findings indicated that SCoRS-TR is a reliable and valid scale for the Turkish population. The scale demonstrated strong internal consistency, with Cronbach's alpha values ranging from 0.937 to 0.940. High interrater reliability (ranging from 0.90 to 0.98) and test-retest reliability (ranging from 0.976 to 0.990) were observed. SCoRS-TR significantly discriminated patients from healthy controls (p<0.001). SCoRS-TR exhibited significant correlations to neurocognitive tests.

Discussion

Results indicated that SCoRS-TR had significant reliability and validity scores that may be useful for evaluating daily life functioning related to cognitive dysfunction in patients with schizophrenia. This approach may be useful for neurocognitive evaluation and monitoring in clinical follow-up and outpatient settings.

背景：精神分裂症的特点是认知功能严重障碍。尽管神经认知障碍在预后中起着至关重要的作用，但由于神经认知评估耗时较长，因此在门诊环境中评估神经认知障碍具有挑战性。SCoRS "精神分裂症认知评定量表 "是一种提供简短认知评估的量表。本研究旨在确定土耳其版 "精神分裂症认知评定量表"（SCoRS-TR）在精神分裂症患者中的有效性和可靠性，并研究 SCoRS 与认知测试之间的相关性：收集了 130 名符合 DSM-5 标准的精神分裂症患者和 40 名健康对照者的数据。方法：收集 130 名符合 DSM-5 标准的精神分裂症患者和 40 名健康对照者的数据，并进行 SCoRS 评分、阳性与阴性综合征量表（PANSS）和神经认知测试：结果：研究结果表明，SCoRS-TR 对土耳其人来说是一个可靠、有效的量表。该量表具有很强的内部一致性，Cronbach's alpha 值在 0.937 至 0.940 之间。研究人员之间的信度（从 0.90 到 0.98）和测试再测信度（从 0.976 到 0.990）都很高。SCoRS-TR 能明显区分患者和健康对照组（p 讨论：结果表明，SCoRS-TR 具有显著的信度和效度，可用于评估精神分裂症患者与认知功能障碍相关的日常生活功能。这种方法可用于临床随访和门诊环境中的神经认知评估和监测。

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引用次数: 0

Closure risk of general hospital psychiatric units: Impact of financial pressures and psychiatrist staffing challenges 综合医院精神科关闭的风险：财务压力和精神科医生人员配备挑战的影响

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-10-29 DOI: 10.1016/j.ajp.2024.104300

Michitaka Funayama, Shigeki Sato, Hiraki Koishikawa, Naoko Satake, On Kato, Masayuki Noguchi, Tomoji Takata, Yusuke Hasegawa, Hisashi Wada, Takaki Akahane, Naohisa Tsujino, Katsuji Nishimura

引用次数: 0

Subcortical and insula functional connectivity aberrations and clinical implications in first-episode schizophrenia 皮层下和脑岛功能连接畸变及其对首发精神分裂症的临床影响

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-10-28 DOI: 10.1016/j.ajp.2024.104298

Bixin Wang, Meng Zhang, Fengmei Fan, Chunyu Yuan, Zhiren Wang, Yunlong Tan, Shuping Tan

Introduction

Schizophrenia is a complex mental disorder whose pathophysiology remains elusive, particularly in the roles of subcortex. This study aims to explore the role of subcortex and insula and their relationship with symptom changes in first-episode schizophrenia (FES) patients by utilizing machine learning algorithms and functional connectivity (FC).

Methods

The study encompasses 261 participants, sourced from two independent samples of FES patients and their matched healthy controls (HC). The discovery dataset includes 77 FES patients at baseline (FES0W) and 77 matched HCs, with the patients undergoing a follow-up scan after eight weeks of antipsychotic treatment (FES8W, N = 34). A validation dataset from another region comprises 47 FES patients and 47 matched HCs.

Results

Significant differences in subcortical FCs were observed between FES and controls, correlating with symptom severity and symptom changes. Machine learning models were developed to diagnose schizophrenia on an individual basis, achieving a balanced accuracy of 79.55 % across diverse centers.

Conclusions

These findings suggest that subcortical connectivity patterns offer potential as biomarkers for schizophrenia, enabling personalized treatment strategies and improving prognosis by facilitating early diagnosis.

导言精神分裂症是一种复杂的精神疾病，其病理生理学仍然难以捉摸，尤其是皮层下的作用。本研究旨在利用机器学习算法和功能连接（FC），探讨皮层下和岛叶的作用及其与首发精神分裂症（FES）患者症状变化的关系。发现数据集包括 77 名基线 FES 患者（FES0W）和 77 名匹配的健康对照组（HC），患者在接受八周的抗精神病治疗后接受随访扫描（FES8W，N = 34）。来自另一个地区的验证数据集包括47名FES患者和47名匹配的HCs。结果观察到FES和对照组之间皮层下FCs存在显著差异，与症状严重程度和症状变化相关。结论这些研究结果表明，皮层下连接模式具有作为精神分裂症生物标记物的潜力，有助于制定个性化治疗策略，并通过早期诊断改善预后。

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引用次数: 0

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Asian journal of psychiatry

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