Pub Date : 2025-11-22DOI: 10.1016/j.ajp.2025.104786
Xinrui Wang , Shaokun Zhao , Yingna Li , Huimei An , Ning Fan , Shuping Tan , Fude Yang
Objective
Cognitive function may decline with age, increasing the risk of dementia. Cognitive training can help to slow down this process. Digital Cognitive Enhancement System (DCES) is a novel home-based adaptive cognitive training system. We aim at evaluating and analyzing the efficacy of DCES in enhancing cognitive functions among the elderly and its neural mechanisms.
Methods
This 10-week study included 64 healthy elderly individuals, conducted as a single-blind, block-randomized controlled trial, registered at the China Clinical Trial Registry (ChiCTR2400091044). Participants were divided into the DCES group and the control group, with sessions occurring 5 days a week, each lasting 0.5 h, for a total of 10 weeks. Cognitive and brain function changes were assessed before and after the intervention, with results analyzed using linear-regression analysis and correlation coefficients calculated.
Results
After 10 weeks of intervention, the DCES group showed significant improvements in overall cognitive function, visuospatial function, memory and attention. DCES training significantly reduced fALFF values in the bilateral supramarginal gyrus (SMG). Its enhancement of immediate memory is closely linked to baseline activation levels in the left SMG.
Conclusion
The DCES training showed positive intervention effects, and changes in bilateral SMG activity may provide neurological support for cognitive ability enhancement.
{"title":"Self-administered home digital cognitive enhancement system (DCES) enhances cognitive function in Chinese healthy elderly and its impact on cerebral cortex function: A randomized controlled trial study","authors":"Xinrui Wang , Shaokun Zhao , Yingna Li , Huimei An , Ning Fan , Shuping Tan , Fude Yang","doi":"10.1016/j.ajp.2025.104786","DOIUrl":"10.1016/j.ajp.2025.104786","url":null,"abstract":"<div><h3>Objective</h3><div>Cognitive function may decline with age, increasing the risk of dementia. Cognitive training can help to slow down this process. Digital Cognitive Enhancement System (DCES) is a novel home-based adaptive cognitive training system. We aim at evaluating and analyzing the efficacy of DCES in enhancing cognitive functions among the elderly and its neural mechanisms.</div></div><div><h3>Methods</h3><div>This 10-week study included 64 healthy elderly individuals, conducted as a single-blind, block-randomized controlled trial, registered at the China Clinical Trial Registry (ChiCTR2400091044). Participants were divided into the DCES group and the control group, with sessions occurring 5 days a week, each lasting 0.5 h, for a total of 10 weeks. Cognitive and brain function changes were assessed before and after the intervention, with results analyzed using linear-regression analysis and correlation coefficients calculated.</div></div><div><h3>Results</h3><div>After 10 weeks of intervention, the DCES group showed significant improvements in overall cognitive function, visuospatial function, memory and attention. DCES training significantly reduced fALFF values in the bilateral supramarginal gyrus (SMG). Its enhancement of immediate memory is closely linked to baseline activation levels in the left SMG.</div></div><div><h3>Conclusion</h3><div>The DCES training showed positive intervention effects, and changes in bilateral SMG activity may provide neurological support for cognitive ability enhancement.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104786"},"PeriodicalIF":4.5,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-22DOI: 10.1016/j.ajp.2025.104789
Kadek Suhardita , Putu Ari Dharmayanti, I.Dewa Ayu Eka Purba Dharma Tari, Rikas Saputra, Erfan Ramadhani, Sri Datuti, Ulfah
{"title":"“Bridging policy and lived realities: A critical commentary on Indonesia’s national mental health plan for adolescents”","authors":"Kadek Suhardita , Putu Ari Dharmayanti, I.Dewa Ayu Eka Purba Dharma Tari, Rikas Saputra, Erfan Ramadhani, Sri Datuti, Ulfah","doi":"10.1016/j.ajp.2025.104789","DOIUrl":"10.1016/j.ajp.2025.104789","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104789"},"PeriodicalIF":4.5,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.ajp.2025.104785
Jingman Li , Shan Sun , Ling Yu , Jilei Chen , Jing Wu , Ruiyan Xie , Yuyun Huang , Liangliang Ping , Zhiyi You
The regional radiomics similarity network (R2SN) provides a structural network-level framework for investigating the neuropathology of major depressive disorder (MDD). In this study, we analyzed T1-weighted magnetic resonance imaging (MRI) data from 830 patients with MDD and 771 healthy controls (HCs) obtained from the REST-meta-MDD Project. Individual R2SNs were constructed using the Brainnetome atlas, and group differences in regional mean connectivity strength (RMCS) were assessed with general linear models (GLMs). We further applied partial least squares regression (PLSR) with leave-one-out cross-validation to evaluate the predictive ability of RMCS for Hamilton Depression Rating Scale-17 (HAMD-17) scores. Compared with HCs, patients with MDD exhibited significantly lower RMCS in cortico-striato-thalamo-cortical (CSTC) regions, including the middle and inferior frontal gyrus, precentral gyrus, superior temporal gyrus, postcentral gyrus, lateral occipital cortex, hippocampus, and caudate nucleus. Subgroup analyses revealed that patients with recurrent MDD showed reduced RMCS in the right dorsal caudate nucleus when compared with HCs, whereas first-episode drug-naïve (FEDN) patients did not. Moreover, the PLSR model demonstrated that RMCS significantly predicted HAMD-17 scores. Together, these findings highlight abnormalities in structural covariance networks in MDD, particularly within CSTC pathways, and underscore the potential of R2SN as a biomarker to guide individualized diagnosis and treatment planning in MDD.
{"title":"Regional radiomics similarity networks reveal CSTC circuit abnormalities and clinical relevance in major depressive disorder","authors":"Jingman Li , Shan Sun , Ling Yu , Jilei Chen , Jing Wu , Ruiyan Xie , Yuyun Huang , Liangliang Ping , Zhiyi You","doi":"10.1016/j.ajp.2025.104785","DOIUrl":"10.1016/j.ajp.2025.104785","url":null,"abstract":"<div><div>The regional radiomics similarity network (R2SN) provides a structural network-level framework for investigating the neuropathology of major depressive disorder (MDD). In this study, we analyzed T1-weighted magnetic resonance imaging (MRI) data from 830 patients with MDD and 771 healthy controls (HCs) obtained from the REST-meta-MDD Project. Individual R2SNs were constructed using the Brainnetome atlas, and group differences in regional mean connectivity strength (RMCS) were assessed with general linear models (GLMs). We further applied partial least squares regression (PLSR) with leave-one-out cross-validation to evaluate the predictive ability of RMCS for Hamilton Depression Rating Scale-17 (HAMD-17) scores. Compared with HCs, patients with MDD exhibited significantly lower RMCS in cortico-striato-thalamo-cortical (CSTC) regions, including the middle and inferior frontal gyrus, precentral gyrus, superior temporal gyrus, postcentral gyrus, lateral occipital cortex, hippocampus, and caudate nucleus. Subgroup analyses revealed that patients with recurrent MDD showed reduced RMCS in the right dorsal caudate nucleus when compared with HCs, whereas first-episode drug-naïve (FEDN) patients did not. Moreover, the PLSR model demonstrated that RMCS significantly predicted HAMD-17 scores. Together, these findings highlight abnormalities in structural covariance networks in MDD, particularly within CSTC pathways, and underscore the potential of R2SN as a biomarker to guide individualized diagnosis and treatment planning in MDD.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104785"},"PeriodicalIF":4.5,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.1016/j.ajp.2025.104775
Triyono Triyono, Rahmi Dwi Febriani, Fitria Kasih
{"title":"Broadening the evidence for hug-robot-mediated communication in autism spectrum disorder","authors":"Triyono Triyono, Rahmi Dwi Febriani, Fitria Kasih","doi":"10.1016/j.ajp.2025.104775","DOIUrl":"10.1016/j.ajp.2025.104775","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104775"},"PeriodicalIF":4.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.ajp.2025.104771
Mythily Subramaniam , Shazana Shahwan , Edimansyah Abdin , Yoke Boon Tan , Savita Gunasekaran , Bernard Chin Wee Tan , Janhavi Ajit Vaingankar , Wei Jie Ong , Amit Arora , Weng Mooi Tan , Porsche Poh , Georg Schomerus , Siow Ann Chong
Background
The stigmatization of people with mental illness is a global phenomenon.
Aims
The current study aimed to (i) assess the extent of stigma and social distancing towards seven mental disorders, and track changes since the last mental health literacy study, and (ii) examine the socio-demographic and other correlates of stigma in the general population of Singapore, using a vignette approach.
Methods
We conducted interviews with 4195 Singapore Residents (aged 18–65) from September 2022 to February 2024, with a response rate of 62.3 %. Respondents were administered the Personal and Perceived scales of the Depression Stigma Scale and the Social Distance Scale to measure personal stigma and social distance, respectively. Multivariable linear regression analyses were conducted to examine associations.
Results
Mean stigma scores were significantly lower across all dimensions : ‘weak-not-sick’ (9.4 vs 10.2, p < 0.001), ‘dangerous/unpredictable’ (11.3 vs 11.6, p = 0.005), and ‘social distance’ (11.6 vs 12.0, p = 0.004) in the current study as compared to the previous study conducted in 2015. However, the magnitude of reduction varied substantially. The largest decline was observed in the ‘weak-not-sick’ dimension (-8.4 %), while ‘dangerous/unpredictable’ (-3.1 %) and ‘social distance’ (-2.8 %) showed smaller reductions.
Conclusions
The significant reduction in the ‘weak-not-sick’ dimension parallels large-scale anti-stigma initiatives in Singapore. However, the persistence of ‘social distance’ highlights a critical gap between improved public knowledge and intended behavior. Ongoing surveillance is necessary to determine whether these trends are sustained and to identify specific strategies that are effective in reducing behavioral stigma.
背景：对精神疾病患者的污名化是一种全球现象。目的：目前的研究旨在(i)评估对七种精神障碍的耻辱感和社会距离的程度，并跟踪自上次心理健康素养研究以来的变化，以及（ii）使用小文章方法检查新加坡普通人群中耻辱感的社会人口统计学和其他相关因素。方法：我们于2022年9月至2024年2月对4195名新加坡居民（18-65岁）进行了访谈，回复率为62.3 %。被调查者分别使用抑郁耻辱感量表的个人和感知量表和社会距离量表来测量个人耻辱感和社会距离。采用多变量线性回归分析来检验相关性。结果：在所有维度中，平均污名得分都显著降低：“弱-未病”（9.4 vs 10.2, p ）结论：“弱-未病”维度的显著降低与新加坡大规模的反污名举措相似。然而，“社会距离”的持续存在凸显了改善的公众知识和预期行为之间的关键差距。有必要进行持续监测，以确定这些趋势是否持续，并确定有效减少行为污名的具体战略。
{"title":"Public stigma towards people with mental disorders in Singapore - Has anything changed?","authors":"Mythily Subramaniam , Shazana Shahwan , Edimansyah Abdin , Yoke Boon Tan , Savita Gunasekaran , Bernard Chin Wee Tan , Janhavi Ajit Vaingankar , Wei Jie Ong , Amit Arora , Weng Mooi Tan , Porsche Poh , Georg Schomerus , Siow Ann Chong","doi":"10.1016/j.ajp.2025.104771","DOIUrl":"10.1016/j.ajp.2025.104771","url":null,"abstract":"<div><h3>Background</h3><div>The stigmatization of people with mental illness is a global phenomenon.</div></div><div><h3>Aims</h3><div>The current study aimed to (i) assess the extent of stigma and social distancing towards seven mental disorders, and track changes since the last mental health literacy study, and (ii) examine the socio-demographic and other correlates of stigma in the general population of Singapore, using a vignette approach.</div></div><div><h3>Methods</h3><div>We conducted interviews with 4195 Singapore Residents (aged 18–65) from September 2022 to February 2024, with a response rate of 62.3 %. Respondents were administered the Personal and Perceived scales of the Depression Stigma Scale and the Social Distance Scale to measure personal stigma and social distance, respectively. Multivariable linear regression analyses were conducted to examine associations.</div></div><div><h3>Results</h3><div>Mean stigma scores were significantly lower across all dimensions : ‘weak-not-sick’ (9.4 vs 10.2, p < 0.001), ‘dangerous/unpredictable’ (11.3 vs 11.6, p = 0.005), and ‘social distance’ (11.6 vs 12.0, p = 0.004) in the current study as compared to the previous study conducted in 2015. However, the magnitude of reduction varied substantially. The largest decline was observed in the ‘weak-not-sick’ dimension (-8.4 %), while ‘dangerous/unpredictable’ (-3.1 %) and ‘social distance’ (-2.8 %) showed smaller reductions.</div></div><div><h3>Conclusions</h3><div>The significant reduction in the ‘weak-not-sick’ dimension parallels large-scale anti-stigma initiatives in Singapore. However, the persistence of ‘social distance’ highlights a critical gap between improved public knowledge and intended behavior. Ongoing surveillance is necessary to determine whether these trends are sustained and to identify specific strategies that are effective in reducing behavioral stigma.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104771"},"PeriodicalIF":4.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.ajp.2025.104774
Marlon S. Frias
{"title":"Methodological reflections on time-series approaches to suicide trends in South Korea","authors":"Marlon S. Frias","doi":"10.1016/j.ajp.2025.104774","DOIUrl":"10.1016/j.ajp.2025.104774","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104774"},"PeriodicalIF":4.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Multidisciplinary Team intervention successfully reduces physical restraint use in a Japanese acute care hospital” [Asian J. Psychiatry 114 (2025) 104766]","authors":"Kyohei Otani, Kyoko Yamada, Minako Terada, Mitsunobu Moriwaki, Hiroko Koh, Tomohiro Kinoshita, Nobuyasu Imbe, Ryota Shindo, Yuko Yamamoto, Shogo Kurushima","doi":"10.1016/j.ajp.2025.104773","DOIUrl":"10.1016/j.ajp.2025.104773","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104773"},"PeriodicalIF":4.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.ajp.2025.104770
Kyohei Otani, Tomohiro Kinoshita, Ryota Shindo, Shogo Kurushima, Saehyeon Kim
{"title":"Cultural vs. demographic pathways to suicide: Japan and Korea during COVID-19","authors":"Kyohei Otani, Tomohiro Kinoshita, Ryota Shindo, Shogo Kurushima, Saehyeon Kim","doi":"10.1016/j.ajp.2025.104770","DOIUrl":"10.1016/j.ajp.2025.104770","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"115 ","pages":"Article 104770"},"PeriodicalIF":4.5,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1016/j.ajp.2025.104769
Rajiv Tandon
{"title":"Monitoring accuracy and balance in pharmacovigilance reporting: The approach of the Asian Journal of Psychiatry","authors":"Rajiv Tandon","doi":"10.1016/j.ajp.2025.104769","DOIUrl":"10.1016/j.ajp.2025.104769","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"114 ","pages":"Article 104769"},"PeriodicalIF":4.5,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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