Asian journal of psychiatry最新文献_第9页

Impaired facial emotion recognition in individuals with bipolar disorder 双相情感障碍患者的面部情绪识别能力受损

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-22 DOI: 10.1016/j.ajp.2024.104250

Yiyang Liu , Yuqing Song , Hui Li , Zhiwei Leng , Mengqian Li , Hongguang Chen

Background

Individuals with bipolar disorder (BD) often struggle with emotional regulation and social interactions, partly due to difficulties in accurately recognizing facial emotions.

Methods

From September 2021 to February 2023, 69 BD individuals-comprising 23 with bipolar manic/hypomanic episode (BME), 23 with bipolar depressive episode (BDE), 23 with bipolar euthymic (EUT)-and 23 healthy controls (HCs) were enrolled. Diagnosis adhered to DSM-IV criteria using M.I.N.I 5.0, alongside assessments via Hamilton Depression Scale 17 and Young Manic Rating Scale. Recognition tasks involving 84 facial expression images across six categories. The Wilcoxon rank-sum test compares two groups, while the Kruskal-Wallis test compares multiple groups with subsequent adjusted pairwise comparisons.

Results

The overall correct recognition rate of facial expressions in the BD group (79 %) was significantly lower than that of the HC group (83 %) (P=0.004). Primary differences were noted in neutral (93 % vs. 100 %, P=0.012) and fear (79 % vs. 86 %, P=0.023) expressions. Within the BD group, correct recognition rates were 71 % for BME, 80 % for BDE, and 80 % for EUT, all lower than in the HC group. Significant differences in correct recognition rates of neutral, fear, and joy expressions were observed among the four groups (P<0.05), with the BME group exhibiting the lowest rate. Misidentification of facial expressions was more frequent in the BD group compared to the HC group, particularly among negative expressions.

Conclusion

Patients with BD demonstrate lower correct recognition and higher misidentification rates of facial expressions, with those experiencing manic episodes showing impaired recognition of neutral, joy, and fear expressions.

方法从 2021 年 9 月到 2023 年 2 月，研究人员招募了 69 名双相情感障碍患者，其中包括 23 名双相躁狂/躁狂发作患者（BME）、23 名双相抑郁发作患者（BDE）、23 名双相优郁患者（EUT）和 23 名健康对照组（HC）。诊断遵循 DSM-IV 标准，使用 M.I.N.I 5.0，并通过汉密尔顿抑郁量表 17 和青年躁狂评定量表进行评估。识别任务涉及六个类别的 84 张面部表情图片。Wilcoxon 秩和检验对两组进行比较，而 Kruskal-Wallis 检验则对多组进行比较，并随后进行调整后的配对比较。结果BD 组面部表情的总体正确识别率（79%）明显低于 HC 组（83%）（P=0.004）。主要差异表现在中性（93% 对 100%，P=0.012）和恐惧（79% 对 86%，P=0.023）表情上。在 BD 组中，BME、BDE 和 EUT 的正确识别率分别为 71%、80% 和 80%，均低于 HC 组。中性、恐惧和喜悦表情的正确识别率在四个组之间存在显著差异（P<0.05），其中 BME 组的识别率最低。结论BD 患者的面部表情识别正确率较低，识别错误率较高，其中躁狂发作的患者对中性、喜悦和恐惧表情的识别能力受损。

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引用次数: 0

Effectiveness of mental health literacy intervention and contact-based education on knowledge, attitude, and stigma towards mental health among secondary school students in Chennai, South India: A cluster randomized controlled trial 心理健康知识干预和接触式教育对南印度金奈中学生心理健康知识、态度和耻辱感的影响：分组随机对照试验

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-21 DOI: 10.1016/j.ajp.2024.104248

M.Suresh Kumar , Hanisha Arulvendan , G. Sanjana , B. Priyadharshni , Chiranjeevi Arumugam , Jothilakshmi Durairaj , Fredric Azariah , Moitreyee Sinha , Vijaya Raghavan , R. Thara

Background

Global trends indicate a rise in mental health disorders among youth, prompting need for effective interventions. Mental health literacy interventions have demonstrated benefits such as improved knowledge, treatment understanding, help-seeking behaviors, and stigma reduction. This study aimed to assess the impact of a comprehensive mental health literacy program on knowledge, attitudes, and stigma related to mental health among secondary school students in Chennai.

Methods

Cluster-randomized controlled trial was conducted among students from four secondary schools. Randomization was at cluster level to minimize contamination. Participating schools provided consent, and all ninth-grade students were invited to participate. Written informed consent was obtained from parents/guardians, and assent was obtained from students. There were no specific exclusion criteria, except for students who declined to participate. Analyses were performed using intention-to-treat principles, with multiple imputation for missing outcome data.

Results

After adjusting for cluster effects, the intervention group showed a significant improvement in attitude scores compared to the control group (mean difference 0.85, 95 % CI: 0.32–1.39, p = 0.002). However, no significant differences were observed between the two groups in terms of knowledge and stigma.

Conclusion

The findings suggest that delivering a mental health literacy curriculum alongside contact-based education involving individuals with lived experiences of mental disorders positively influences students' attitudes toward mental health. Although no significant changes were observed in knowledge and stigma levels, the integration of mental health literacy programs with personal narratives from those with lived experiences holds promise for addressing mental health stigma and promoting positive attitudes among school students.

背景全球趋势表明，青少年心理健康失调的人数在增加，因此需要采取有效的干预措施。心理健康扫盲干预措施已显示出其益处，如改善知识、治疗理解、求助行为和减少耻辱感。本研究旨在评估综合心理健康扫盲项目对钦奈中学生心理健康相关知识、态度和耻辱感的影响。随机分组以尽量减少污染。参与学校提供同意书，并邀请所有九年级学生参与。试验获得了家长/监护人的书面知情同意，并征得了学生的同意。除拒绝参与的学生外，没有特定的排除标准。结果经调整群组效应后，干预组与对照组相比，态度评分有显著改善（平均差异为 0.85，95 % CI：0.32-1.39，p = 0.002）。结论：研究结果表明，在开展心理健康扫盲课程的同时，开展有心理障碍亲身经历者参与的接触式教育，会对学生的心理健康态度产生积极影响。虽然在知识水平和耻辱感水平上没有观察到明显的变化，但将心理健康知识普及课程与有亲身经历者的个人讲述相结合，有望解决心理健康耻辱感问题，并促进在校学生树立积极的态度。

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引用次数: 0

Examinations of the VR techniques for craving and the effectiveness of mindfulness-based practice on the changes in the HRV index 研究针对渴望的 VR 技术和正念练习对心率变异指数变化的影响

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-19 DOI: 10.1016/j.ajp.2024.104243

Kun-Hua Lee, Shinche Chen

引用次数: 0

Therapeutic potential of ketamine in management of epilepsy: Clinical implications and mechanistic insights 氯胺酮治疗癫痫的潜力：临床意义和机理认识。

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-19 DOI: 10.1016/j.ajp.2024.104246

Yunfei Tan , Kenji Hashimoto

Epilepsy, a widespread neurological disorder, affects approximately 50 million people worldwide. This disorder is typified by recurring seizures due to abnormal neuron communication in the brain. The seizures can lead to severe ischemia and hypoxia, potentially threatening patients' lives. However, with proper diagnosis and treatment, up to 70 % of patients can live without seizures. The causes of epilepsy are complex and multifactorial, encompassing genetic abnormalities, structural brain anomalies, ion channel dysfunctions, neurotransmitter imbalances, neuroinflammation, and immune system involvement. These factors collectively disrupt the crucial balance between excitation and inhibition within the brain, leading to epileptic seizures. The management of treatment-resistant epilepsy remains a considerable challenge, necessitating innovative therapeutic approaches. Among emerging potential treatments, ketamine–a drug traditionally employed for anesthesia and depression–has demonstrated efficacy in reducing seizures. It is noteworthy that, independent of its anti-epileptic effects, ketamine has been found to improve the balance between excitatory and inhibitory (E/I) activities in the brain. The balance is crucial for maintaining normal neural function, and its disruption is widely considered a key driver of epileptic seizures. By acting on N-methyl-D-aspartate (NMDA) receptors and other potential mechanisms, ketamine may regulate neuronal excitability, reduce excessive synchronized neural activity, and counteract epileptic seizures. This positive impact on E/I balance reinforces the potential of ketamine as a promising drug for treating epilepsy, especially in patients who are insensitive to traditional anti-epileptic drugs. This review aims to consolidate the current understanding of ketamine’s therapeutic role in epilepsy. It will focus its impact on neuronal excitability and synaptic plasticity, its neuroprotective qualities, and elucidate the drug’s potential mechanisms of action in treating epilepsy. By scrutinizing ketamine's impact and mechanisms in various types of epilepsy, we aspire to contribute to a more comprehensive and holistic approach to epilepsy management.

癫痫是一种广泛存在的神经系统疾病，全世界约有 5000 万人患有这种疾病。这种疾病的典型特征是由于大脑神经元交流异常而导致癫痫反复发作。癫痫发作会导致严重的缺血和缺氧，对患者的生命构成潜在威胁。然而，经过适当的诊断和治疗，多达 70% 的患者可以在没有癫痫发作的情况下生活。癫痫的病因复杂且多因素，包括遗传异常、大脑结构异常、离子通道功能障碍、神经递质失衡、神经炎症和免疫系统参与。这些因素共同破坏了大脑内兴奋和抑制之间的重要平衡，导致癫痫发作。治疗耐药性癫痫仍然是一项巨大的挑战，需要创新的治疗方法。在新出现的潜在治疗方法中，氯胺酮--一种传统上用于麻醉和抑郁的药物--已被证明能有效减少癫痫发作。值得注意的是，氯胺酮除了具有抗癫痫作用外，还能改善大脑兴奋和抑制（E/I）活动之间的平衡。这种平衡对于维持正常的神经功能至关重要，而破坏这种平衡则被广泛认为是癫痫发作的关键驱动因素。氯胺酮通过作用于 N-甲基-D-天冬氨酸（NMDA）受体和其他潜在机制，可以调节神经元的兴奋性，减少过度同步的神经活动，并对抗癫痫发作。氯胺酮对E/I平衡的积极影响增强了氯胺酮作为治疗癫痫药物的潜力，尤其是对传统抗癫痫药物不敏感的患者。本综述旨在巩固目前对氯胺酮在癫痫治疗中作用的认识。它将重点阐述氯胺酮对神经元兴奋性和突触可塑性的影响及其神经保护作用，并阐明该药物在治疗癫痫方面的潜在作用机制。通过仔细研究氯胺酮对各种类型癫痫的影响和作用机制，我们希望能为癫痫治疗提供一种更全面、更综合的方法。

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引用次数: 0

2024 FDA-approved psychotropic medications: A conspectus 2024 美国食品及药物管理局批准的精神药物：综述

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-17 DOI: 10.1016/j.ajp.2024.104249

Ahmed Naguy, Nadyah Alayadhi, Ali Al-Tajali, Victoria Ozidu

As of August 2024, (US) FDA has granted approval for a number of psychotropic drugs on market that might usher an innovative sparkle in psychopharmacotherapy. This is a recap to update busy clinicians.

截至 2024 年 8 月，（美国）FDA 已批准了许多精神药物上市，它们可能会为精神药物治疗带来创新的火花。在此，我们将为忙碌的临床医生提供最新信息。

引用次数: 0

Exploring the regulatory framework of psychedelics in the US & Europe 探索美国和欧洲的迷幻剂监管框架

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-17 DOI: 10.1016/j.ajp.2024.104242

Hitesh Kumar Behera , Ramesh Joga , Sravani Yerram , Praveena Karnati , Tejaswini Mergu , Kajal Gandhi , Sowndharya M , Deepak Nathiya , Ravindra Pal Singh , Saurabh Srivastava , Sandeep Kumar

Psychedelic drug therapy has gained prominence for its potential in treating various mental health conditions, including depression, post-traumatic stress disorder (PTSD), and anxiety. Psychedelic treatment differs from conventional psychiatric approaches in mode of action, legal status, and treatment approach. This work delves into the therapeutic potential, mechanisms, and regulatory approvals of key psychedelic substances like psilocybin, 3,4-Methyl enedioxy methamphetamine (MDMA), mescaline, ketamine, and Lysergic acid diethylamide (LSD). It also provides an overview of legal aspects, and regulations surrounding psychedelics in the US & Europe, emphasizing their Schedule I classification due to potential misuse. The United States Food & Drug Administration (USFDA) closely monitors psychedelics, employing expedited pathways for evaluation. Further, recent guidance from the FDA on considerations for clinical Investigations supports the safe development of psychedelics for human welfare. European Medicines Agency (EMA) regulators focus on atypical psychedelics, addressing challenges in safety and efficacy. Marketed products, such as Spravato nasal spray, face limited distribution due to safety concerns. The call for careful regulation and legislation is essential for harnessing psychedelics' potential for therapeutic benefits and human welfare.

迷幻药物疗法因其在治疗抑郁症、创伤后应激障碍（PTSD）和焦虑症等各种精神疾病方面的潜力而备受瞩目。迷幻治疗在作用方式、法律地位和治疗方法上都有别于传统的精神病治疗方法。本著作深入探讨了主要迷幻药物的治疗潜力、机制和监管批准情况，如迷幻素、3,4-甲基二氧甲基苯丙胺（MDMA）、麦司卡林、氯胺酮和麦角酰二乙胺（LSD）。报告还概述了美国和欧洲有关迷幻药的法律和法规，强调了迷幻药因可能被滥用而被列入附表 I 的情况。美国食品和药物管理局（USFDA）密切监控迷幻剂，并采用快速评估途径。此外，美国食品和药物管理局最近发布的临床研究注意事项指南也支持为人类福祉安全开发迷幻剂。欧洲药品管理局（EMA）的监管机构重点关注非典型迷幻药，应对安全性和有效性方面的挑战。市场上销售的产品，如 Spravato 鼻用喷雾剂，由于安全问题，销售受到限制。呼吁谨慎监管和立法对于利用迷幻剂的潜在治疗功效和人类福祉至关重要。

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引用次数: 0

Perceived helplessness is the central symptom of mental distress in Chinese physicians: Network analysis and replication of stress, burnout, depression, and anxiety 知觉无助是中国医生精神痛苦的核心症状：压力、职业倦怠、抑郁和焦虑的网络分析与复制

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-17 DOI: 10.1016/j.ajp.2024.104247

Zejun Li , Pu Peng , Kewen Yan, Xin Wang, Xiaoyu Zhang, Huixue Xu, Xueyi Li, Min Wu, Peizhen Li, Qijian Deng, Tieqiao Liu , Yi-Yuan Tang , Qiuxia Wu

引用次数: 0

Understanding the costs and economic impact of mental disorders in South Asia: A systematic review 了解南亚精神障碍的成本和经济影响：系统回顾

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-16 DOI: 10.1016/j.ajp.2024.104239

David McDaid , Aishwarya Lakshmi Vidyasagaran , Muhammed Nasir , Simon Walker , Judy Wright , Krishna Prasad Muliyala , Sreekanth Thekkumkara , Rumana Huque , Mehreen Riaz Faisal , Saumit Benkalkar , Mohammod Akbar Kabir , Claire Russell , Najma Siddiqi

Background

Mental disorders remain the most significant contributor to years lived with disability in South Asia, yet governmental health expenditure on mental health in South Asia remains very low with limited strategic policy development. To strengthen the case for action it is important to better understand the profound economic costs associated with poor mental health. Methods: We conducted a systematic review on the costs of all mental disorders, as well as intentional self-harm and suicide, in the World Bank South Asia Region. Ten global and South Asian databases as well as grey literature sources were searched. Results: 72 studies were identified, including 38 meeting high quality criteria for good reporting of costs. Of these, 27 covered India, five Pakistan, four Nepal and three Bangladesh and Sri Lanka. Most studies focused on depressive disorders (15), psychoses (14) and harmful alcohol use (7); knowledge of economic impacts for other conditions was limited. Profound economic impacts within and beyond health care systems were found. In 15 of 18 studies which included productivity losses to individuals and/or carers, these costs more than outweighed costs of health care. Conclusion: Mental disorders represent a considerable economic burden, but existing estimates are conservative as they do not consider long-term impacts or the full range of conditions. Modelling studies could be employed covering longer time periods and more conditions. Clear distinctions should be reported between out-of-pocket and health system costs, as well as between mental health service-specific and physical health-related costs.

背景在南亚，精神障碍仍然是造成残疾生活年数的最主要因素，但南亚政府在精神健康方面的卫生支出仍然很低，战略政策制定也很有限。为了加强行动力度，必须更好地了解与不良心理健康相关的巨大经济成本。方法：我们对世界银行南亚地区所有精神障碍以及蓄意自残和自杀的成本进行了系统回顾。我们检索了十个全球和南亚数据库以及灰色文献资料。结果：确定了 72 项研究，其中 38 项符合高质量标准，对成本进行了详细报告。其中 27 项涉及印度，5 项涉及巴基斯坦，4 项涉及尼泊尔，3 项涉及孟加拉国和斯里兰卡。大多数研究侧重于抑郁症（15 项）、精神病（14 项）和酗酒（7 项）；对其他疾病的经济影响了解有限。研究发现，医疗保健系统内部和外部都会产生巨大的经济影响。在 18 项研究中，有 15 项研究包括了个人和/或照护者的生产力损失，这些成本超过了医疗成本。结论精神障碍造成了相当大的经济负担，但现有的估算是保守的，因为它们没有考虑到长期影响或全部病症。可以采用涵盖更长时间段和更多病症的模型研究。应明确区分自付费用和医疗系统费用，以及精神健康服务相关费用和身体健康相关费用。

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引用次数: 0

Abnormal resting-state functional connectivity of the right anterior cingulate cortex in chronic ketamine users and its correlation with cognitive impairments 慢性氯胺酮使用者右前扣带回皮层异常的静息态功能连接及其与认知障碍的相关性

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-14 DOI: 10.1016/j.ajp.2024.104199

Jun Zhong , Fengchun Wu , Huawang Wu , Hongbo He , Zhaohua Zhang , Ni Fan

Background

Chronic ketamine use leads to cognitive impairments, however, the neural mechanisms underpinning these impairments are still unclear.

Aims

Many studies showed Anterior cingulate cortex (ACC)is strongly involved in cognition and drug addiction, as supported by our previous studies. The objective of this study was to assess the variations in resting-state functional connectivity (FC) changes in the right anterior cingulate cortex (ACC) of chronic ketamine users (CKUs) and their relationship with cognitive performance.

Methods

The study enrolled 28 chronic ketamine users (CKUs) and 30 healthy controls (HCs). Resting-state functional magnetic resonance imaging (fMRI) data were gathered from both groups. Cognitive functions were evaluated using the MATRICS Consensus Cognitive Battery (MCCB).

Results

CKUs demonstrated significantly poorer cognitive performance than HCs in various cognitive domains, including Visual Learning, Speed of Processing, Working Memory, and the composite score of MCCB. Group-level comparisons revealed that CKUs exhibited enhanced functional connectivity between the right ACC and the right postcentral gyrus (PCG) compared to HCs. There was a positive relationship between the connectivity of right ACC-PCG and reasoning and problem-solving score, but there was no significant association with the characteristics of ketamine use.

Conclusion

CKUs showed enhanced connectivity between the right ACC and the right PCG. This enhanced functional connectivity may indicate functional compensation for cognitive deficits in CKUs, especially for reasoning and problem-solving impairments in CKUs.

研究目的：许多研究表明，前扣带皮层（ACC）与认知和药物成瘾密切相关。本研究旨在评估慢性氯胺酮使用者（CKUs）右侧前扣带皮层（ACC）的静息态功能连接（FC）变化及其与认知表现的关系。研究收集了两组人的静息态功能磁共振成像（fMRI）数据。结果慢性氯胺酮使用者在视觉学习、处理速度、工作记忆和MCCB综合评分等多个认知领域的认知表现均显著低于健康对照者。组间比较显示，CKUs与HCs相比，右侧ACC和右侧中央后回（PCG）之间的功能连接性增强。右侧ACC-PCG的连通性与推理和问题解决得分之间存在正相关，但与氯胺酮使用特征无显著关联。这种功能连接的增强可能表明了对氯胺酮依赖者认知缺陷的功能补偿，尤其是对氯胺酮依赖者推理和问题解决能力缺陷的补偿。

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引用次数: 0

Cardiometabolic biomarkers and comorbid metabolic syndrome in schizophrenia: A cross-sectional study of long-term clozapine/olanzapine users 精神分裂症患者的心脏代谢生物标志物和合并代谢综合征：一项针对氯氮平/奥氮平长期使用者的横断面研究

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry

Pub Date : 2024-09-13 DOI: 10.1016/j.ajp.2024.104244

Kuo-Chan Wang , Hung-Yu Chan , Wei-Shiung Yang , Yen-Ming Huang , Yunn-Fang Ho , Tzung-Jeng Hwang

Objectives

Second-generation antipsychotics (SGAs) are often prescribed for patients with schizophrenia; however, SGAs are associated with the risk of metabolic syndrome (MetS). This study aimed to investigate the clinical and biochemical determinants of SGA-related MetS.

Methods

Patients with schizophrenia, aged between 20 and 65 years, and under clozapine or olanzapine treatment for at least 9 months, were recruited from a mental hospital. Demographic, comorbidity, clinical status, laboratory, and drug regimen data were collected through chart review. Circulating levels of adiponectin, thyroid hormone responsive protein, and fatty acid binding protein 4 (FABP4) were assayed. Multiple logistic regression was used to identify risk predictors of MetS.

Results

A total of 176 participants were enrolled, including 138 (78.4 %) clozapine users and 38 (21.6 %) olanzapine users. Forty-five (25.6 %) patients were classified as having MetS. The duration of clozapine or olanzapine usage was significantly shorter in those with MetS (p=0.026) than those without MetS. Patients with MetS had a significantly higher serum FABP4 concentration than their counterparts (22.5 ± 8.8 ng/mL vs. 15.7 ± 6.7 ng/mL, p<0.001), and also a significantly lower adiponectin level (6.9 ±4.0 mg/mL vs. 11.6 ± 6.6 mg/mL, p<0.001). A FABP4 level ≥ 16.98 ng/mL (OR: 24.16, 95 % CI: 7.47–78.09, p<0.001) was positively correlated with MetS, whereas serum adiponectin level was inversely correlated with MetS (OR: 0.7980, 95 % CI: 0.70–0.90, p<0.001).

Conclusions

Adiponectin, FABP4, and certain clinical covariates and comedications were highly correlated with SGA-related MetS. Further studies are required to investigate the underlying mechanisms.

目的：第二代抗精神病药物（SGA）是精神分裂症患者的常用处方药；然而，SGA与代谢综合征（MetS）的风险有关。本研究旨在调查与 SGA 相关的代谢综合征的临床和生化决定因素。方法从一家精神病院招募年龄在 20 岁至 65 岁之间、接受氯氮平或奥氮平治疗至少 9 个月的精神分裂症患者。通过病历审查收集了患者的人口统计学、合并症、临床状态、实验室和用药方案等数据。检测了脂肪连素、甲状腺激素反应蛋白和脂肪酸结合蛋白 4 (FABP4) 的循环水平。结果共有176名参与者参加了研究，其中包括138名氯氮平使用者（78.4%）和38名奥氮平使用者（21.6%）。45名患者（25.6%）被归类为 MetS 患者。有 MetS 的患者使用氯氮平或奥氮平的时间（p=0.026）明显短于无 MetS 的患者。MetS 患者的血清 FABP4 浓度明显高于同类患者（22.5 ± 8.8 纳克/毫升 vs. 15.7 ± 6.7 纳克/毫升，p<0.001），而脂肪连通素水平也明显低于同类患者（6.9 ± 4.0 毫克/毫升 vs. 11.6 ± 6.6 毫克/毫升，p<0.001）。FABP4水平≥16.98 ng/mL（OR：24.16，95 % CI：7.47-78.09，p<0.001）与MetS呈正相关，而血清脂肪连接蛋白水平与MetS呈反相关（OR：0.结论脂联素、FABP4、某些临床协变量和合并症与 SGA 相关 MetS 高度相关。需要进一步研究其潜在机制。

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引用次数: 0