Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp132-134
{"title":"Key Controlled Wheel Chair using Arduino Uno","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp132-134","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp132-134","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77989163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p399
S. Kasula, S. Gyaneshwari
Schiff bases were synthesized by condensation of the aldehyde group of 5-nitro thiophen-2- carboxaldehyde with different fluoro substituted aromatic primary amines. All the synthesized compounds (3a-c) were characterized by various spectral techniques and the completion of reaction were confirmed by TLC. In vitro antimicrobial activity of the synthesized compounds was evaluated using minimum inhibitory concentration against Gram-positive and Gram-negative microbial strains. The results of antimicrobial study revealed that compounds 3a and 3c were active and exhibited better inhibitory activities as compared with standard drug levofloxacin. The molecular docking studies have higher binding affinity with the receptors enzymes enoyl-ACP reductase. Density functional theory (DFT) calculations at the B3LYP method and 6-31G(d,p) basis set have been carried out to investigate the equilibrium geometry of the ligands. Moreover, total energy, energy of HOMO and LUMO and MEP and other quantum parameters were also calculated. The DFT calculations suggested the lowest energy gap of the studied compounds, which were chemically reactive and may serve as potential drug candidates.
{"title":"Microwave Assisted Synthesis and Computational Approach of\u00005-Nitrothiophene-2-carboxaldehyde Derived Schiff Bases as Antibacterial Agents","authors":"S. Kasula, S. Gyaneshwari","doi":"10.14233/ajomc.2022.ajomc-p399","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p399","url":null,"abstract":"Schiff bases were synthesized by condensation of the aldehyde group of 5-nitro thiophen-2- carboxaldehyde with different fluoro substituted aromatic primary amines. All the synthesized compounds (3a-c) were characterized by various spectral techniques and the completion of reaction were confirmed by TLC. In vitro antimicrobial activity of the synthesized compounds was evaluated using minimum inhibitory concentration against Gram-positive and Gram-negative microbial strains. The results of antimicrobial study revealed that compounds 3a and 3c were active and exhibited better inhibitory activities as compared with standard drug levofloxacin. The molecular docking studies have higher binding affinity with the receptors enzymes enoyl-ACP reductase. Density functional theory (DFT) calculations at the B3LYP method and 6-31G(d,p) basis set have been carried out to investigate the equilibrium geometry of the ligands. Moreover, total energy, energy of HOMO and LUMO and MEP and other quantum parameters were also calculated. The DFT calculations suggested the lowest energy gap of the studied compounds, which were chemically reactive and may serve as potential drug candidates.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80669879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp110-116
{"title":"A Review - Various Challenges & Solutions for IoT based System using 5G Technology","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp110-116","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp110-116","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81962658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp214-219
{"title":"A Comparative Study of Environment Friendly Alternate to Synthetic Lubricants","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp214-219","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp214-219","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78926681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p398
Sonali Khandelwal, Aman Dev Dani, Yogesh Kumar, Naman Janghel, Piyush Kesharwani
Clerodendrum chinense a plant native to south Asia is a perennial shrub with triangular ovate shaped leaves. Present study involves the study of secondary metabolites and antibacterial activity of Clerodendrum chinense. Phytochemical analysis of plant extract shows the presence of active phytoconstituents like protein, carbohydrate, sterols, alkaloids, tannins, saponins. TLC analysis revealed the presence of β-sitosterol in the extract, which is an important phytosterol. Antibacterial activity shows characteristic inhibition against two different strain i.e. E. coli and Pseudomonas, which suggests the plant might show promising results in the field of antibiotics.
{"title":"Study of Secondary Metabolites and Antibacterial Activity of\u0000Clerodendrum chinense found in Chhattisgarh Region, India","authors":"Sonali Khandelwal, Aman Dev Dani, Yogesh Kumar, Naman Janghel, Piyush Kesharwani","doi":"10.14233/ajomc.2022.ajomc-p398","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p398","url":null,"abstract":"Clerodendrum chinense a plant native to south Asia is a perennial shrub with triangular ovate shaped leaves. Present study involves the study of secondary metabolites and antibacterial activity of Clerodendrum chinense. Phytochemical analysis of plant extract shows the presence of active phytoconstituents like protein, carbohydrate, sterols, alkaloids, tannins, saponins. TLC analysis revealed the presence of β-sitosterol in the extract, which is an important phytosterol. Antibacterial activity shows characteristic inhibition against two different strain i.e. E. coli and Pseudomonas, which suggests the plant might show promising results in the field of antibiotics.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76454175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p371
D. Mishra, Ashutosh Singh, S. K. Mishra, Priti Singh, Abhishek Singh, J. Kumar
QSAR analysis of the derivatives of thiadiazole and quinoxaline has been made for antiepileptic activity (pED50) using quantum mechanical and energy descriptors. The descriptors ionization potential, HOMO energy, LUMO energy, electron affinity, total energy, conformation minimum energy and log P have been used for QSAR analysis. The PM3 method has been employed for the calculation of descriptors. The best QSAR model has been obtained by using the descriptors electron affinity, total energy, conformation minimum energy and log P in which regression coefficient is 0.836651 and cross-validation coefficient is 0.761455. Also the single descriptor total energy is able to produce good QSAR model and hence the antiepileptic activity of any compound of the series can be predicted by calculating the value of total energy.
{"title":"PM3 Method based QSAR Study of the Derivatives of Thiadiazole and Quinoxaline\u0000for Antiepileptic Activity using Quantum Mechanical and Energy Descriptors","authors":"D. Mishra, Ashutosh Singh, S. K. Mishra, Priti Singh, Abhishek Singh, J. Kumar","doi":"10.14233/ajomc.2022.ajomc-p371","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p371","url":null,"abstract":"QSAR analysis of the derivatives of thiadiazole and quinoxaline has been made for antiepileptic activity (pED50) using quantum mechanical and energy descriptors. The descriptors ionization potential, HOMO energy, LUMO energy, electron affinity, total energy, conformation minimum energy and log P have been used for QSAR analysis. The PM3 method has been employed for the calculation of descriptors. The best QSAR model has been obtained by using the descriptors electron affinity, total energy, conformation minimum energy and log P in which regression coefficient is 0.836651 and cross-validation coefficient is 0.761455. Also the single descriptor total energy is able to produce good QSAR model and hence the antiepileptic activity of any compound of the series can be predicted by calculating the value of total energy.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76714769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp243-247
{"title":"Domestic Resistance Spot Welding Equipment Design and Assembly","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp243-247","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp243-247","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75861258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp139-142
{"title":"Moving Vehicle Accident Detection and Alerting System using IOT","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp139-142","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp139-142","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78744154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp37-42
{"title":"Geopolymer Concrete as a Retrofitting Material for Beam Column Joint – A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp37-42","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp37-42","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73290834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p370
D. Mishra, Ashutosh Singh, S. Mishra, Priti Singh, Abhishek Singh
QSAR study of the derivatives of thiadiazole and quinoxaline has been performed for the antiepileptic activity using the topological descriptors viz., molar refractivity, shape index (basic kappa, order 1), shape index (basic kappa, order 2), shape index (basic kappa, order 3), valence connectivity index (order 0, standard), valence connectivity index (order 1, standard) and valence connectivity index (order 2, standard). In the best QSAR model, the descriptors are molar refractivity, shape index (basic kappa, order 1), shape index (basic kappa, order 3) and valence connectivity index (order 0, standard). In this QSAR model, the regression coefficient is 0.872435 and cross-validation coefficient is 0.832189, which indicate that this QSAR model can be used to predict the antiepileptic activity of any compound belonging to this series. QSAR model developed using single descriptor shape index (basic kappa, order 1) or shape index (basic kappa, order 3) or valence connectivity index (order 2, standard) also has good predictive power.
{"title":"PM3 Method based QSAR Study of the Derivatives of Thiadiazole and Quinoxaline\u0000for Antiepileptic Activity using Topological Descriptors","authors":"D. Mishra, Ashutosh Singh, S. Mishra, Priti Singh, Abhishek Singh","doi":"10.14233/ajomc.2022.ajomc-p370","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p370","url":null,"abstract":"QSAR study of the derivatives of thiadiazole and quinoxaline has been performed for the antiepileptic activity using the topological descriptors viz., molar refractivity, shape index (basic kappa, order 1), shape index (basic kappa, order 2), shape index (basic kappa, order 3), valence connectivity index (order 0, standard), valence connectivity index (order 1, standard) and valence connectivity index (order 2, standard). In the best QSAR model, the descriptors are molar refractivity, shape index (basic kappa, order 1), shape index (basic kappa, order 3) and valence connectivity index (order 0, standard). In this QSAR model, the regression coefficient is 0.872435 and cross-validation coefficient is 0.832189, which indicate that this QSAR model can be used to predict the antiepileptic activity of any compound belonging to this series. QSAR model developed using single descriptor shape index (basic kappa, order 1) or shape index (basic kappa, order 3) or valence connectivity index (order 2, standard) also has good predictive power.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89487579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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