Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p381
M. Pradeep, V. Shudarsan, M. Kaviraj, V. Lakshimi, D. Satheesh
Cervical cancer is a kind of cancer, which mainly occurs in the lower portion of uterus. Human papilloma virus plays a major role in the occurrence of cervical cancer. Major symptoms are vaginal bleeding, foul odour in vagina, pelvic pain, etc. It is mostly diagnosed by biopsy. Chemotherapy, radiation and surgery are the widely used treatments for cervical cancer, but the main drawback was their side effects. To avoid these conditions people might follow the ancient methods of treatment. Medicinal plants got wide attention in the current society to cure various diseases. The seagrass obtained from the seashores possess a wide range of medicinal properties like anticancer activity. In this study, the anticancer potentials of the seagrass, Syringodium isoetifolium was checked with the help of MTT and Comet assays. The various functional compounds present in the seagrass were also detected by FT-IR analysis. From the results obtained from MTT assay, the least inhibitory concentration of the sample was found to be 35.63 μg/mL. Further results obtained from the Comet assay prove that the sample has the ability to kill the cancer cells. This study concludes that the methanolic extract of Syringodium isoetifolium can be used as an alternative and marine based source for the treatment of cervical cancer.
{"title":"Screening of Anticancer Potential and DNA Damage Ability of\u0000Syringodium isoetifolium against HeLa Cell Line","authors":"M. Pradeep, V. Shudarsan, M. Kaviraj, V. Lakshimi, D. Satheesh","doi":"10.14233/ajomc.2022.ajomc-p381","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p381","url":null,"abstract":"Cervical cancer is a kind of cancer, which mainly occurs in the lower portion of uterus. Human papilloma virus plays a major role in the occurrence of cervical cancer. Major symptoms are vaginal bleeding, foul odour in vagina, pelvic pain, etc. It is mostly diagnosed by biopsy. Chemotherapy, radiation and surgery are the widely used treatments for cervical cancer, but the main drawback was their side effects. To avoid these conditions people might follow the ancient methods of treatment. Medicinal plants got wide attention in the current society to cure various diseases. The seagrass obtained from the seashores possess a wide range of medicinal properties like anticancer activity. In this study, the anticancer potentials of the seagrass, Syringodium isoetifolium was checked with the help of MTT and Comet assays. The various functional compounds present in the seagrass were also detected by FT-IR analysis. From the results obtained from MTT assay, the least inhibitory concentration of the sample was found to be 35.63 μg/mL. Further results obtained from the Comet assay prove that the sample has the ability to kill the cancer cells. This study concludes that the methanolic extract of Syringodium isoetifolium can be used as an alternative and marine based source for the treatment of cervical cancer.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86357259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p360
Priyanka N. Chhajed, R. B. Patil
In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.
{"title":"Exploring 3D QSAR Study of Pyridone-Pyrimidone Derivatives as Glucokinase\u0000Activators in Treatment of Diabetes Mellitus by using CoMFA Method","authors":"Priyanka N. Chhajed, R. B. Patil","doi":"10.14233/ajomc.2022.ajomc-p360","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p360","url":null,"abstract":"In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91424291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p364
M.B. Zade, S. N. Ibatte
A new series of Schiff bases of 3-(4-substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2- ylimino)pentane-2-one having various substituents of aryl attached to acetoacetone by Knovengel condensation and substituted 1,3,4-thiadiazole were synthesized by using solid supported tetrabutylammonium hydrogen sulfate in microwave irradiation. The synthesized Schiff bases have been evaluated by 1H NMR, elemental analysis, FTIR, mass spectroscopy. All Schiff bases have been screened for their antimicrobial activities. These compounds possess good result of antimicrobial studies.
{"title":"Ultrasound Assisted New Imines of 3E-3-(4-Substituted benzylidene)-4-(substituted-1,3,4-\u0000thiadiazole-2-ylimino)pentane-2-one and their Antimicrobial Studies","authors":"M.B. Zade, S. N. Ibatte","doi":"10.14233/ajomc.2022.ajomc-p364","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p364","url":null,"abstract":"A new series of Schiff bases of 3-(4-substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2- ylimino)pentane-2-one having various substituents of aryl attached to acetoacetone by Knovengel condensation and substituted 1,3,4-thiadiazole were synthesized by using solid supported tetrabutylammonium hydrogen sulfate in microwave irradiation. The synthesized Schiff bases have been evaluated by 1H NMR, elemental analysis, FTIR, mass spectroscopy. All Schiff bases have been screened for their antimicrobial activities. These compounds possess good result of antimicrobial studies.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88069753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp48-50
{"title":"Review Paper on Net Zero Energy Buildings","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp48-50","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp48-50","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74815898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp83-85
{"title":"Stabilization Using Fly Ash of Clayey Soil – A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp83-85","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp83-85","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82221451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p357
D. Gaikwad, R. Murkute, S. Gaikwad
In present study, the synthesized substituted homoisoflavonoid derivatives were screened for their in vivo/in vitro antiarthritic activity, in vitro anti-inflammatory and DPPH free radical scavenging activity. The male Wistar rats were used for investigation of in vivo antiarthritic activity against complete freund’s adjuvant (CFA) induced arthritis and assessment was done for change in paw volume, serum marker enzymes (ALP, SGOT and SGPT) and membrane stabilization potential. in vitro anti-inflammatory activity was assessed by the protein denaturation method. In vitro free radical scavenging activity was assessed by the DPPH method. The result indicated that compound HIFa showed a significant antiarthritic activity as compared to other substituted homoisoflavonoid derivatives. The significant membrane stabilization and inhibition of protein denaturation showed in vitro antiarthritic and antiinflammatory activity of substituted homoisoflavonoid derivatives. The substituted homoisoflavonoid derivatives showed dose dependent DPPH free radical scavenging activity. From the present study, it was observed that the iodo derivative of substituted homoisoflavonoid derivatives have significant pharmacological activities as compared to floro and hydroxyl derivatives.
{"title":"Pharmacological Investigation of Fluoro, Iodo and Hydroxy Derivative of\u0000Chloro Substituted Homoisoflavonoids","authors":"D. Gaikwad, R. Murkute, S. Gaikwad","doi":"10.14233/ajomc.2022.ajomc-p357","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p357","url":null,"abstract":"In present study, the synthesized substituted homoisoflavonoid derivatives were screened for their in vivo/in vitro antiarthritic activity, in vitro anti-inflammatory and DPPH free radical scavenging activity. The male Wistar rats were used for investigation of in vivo antiarthritic activity against complete freund’s adjuvant (CFA) induced arthritis and assessment was done for change in paw volume, serum marker enzymes (ALP, SGOT and SGPT) and membrane stabilization potential. in vitro anti-inflammatory activity was assessed by the protein denaturation method. In vitro free radical scavenging activity was assessed by the DPPH method. The result indicated that compound HIFa showed a significant antiarthritic activity as compared to other substituted homoisoflavonoid derivatives. The significant membrane stabilization and inhibition of protein denaturation showed in vitro antiarthritic and antiinflammatory activity of substituted homoisoflavonoid derivatives. The substituted homoisoflavonoid derivatives showed dose dependent DPPH free radical scavenging activity. From the present study, it was observed that the iodo derivative of substituted homoisoflavonoid derivatives have significant pharmacological activities as compared to floro and hydroxyl derivatives.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90923695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp17-19
{"title":"A Review on the Strength Aspects of Light Weight Concrete Using Ultra-light Weight Foamed Glass Aggregate","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp17-19","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp17-19","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76198181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p356
M. Kaleeswari, P. S. Harikrishnan
1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.
{"title":"Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and\u0000Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-\u00002′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents","authors":"M. Kaleeswari, P. S. Harikrishnan","doi":"10.14233/ajomc.2022.ajomc-p356","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p356","url":null,"abstract":"1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79197923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p372
S. Sanjay, Shashiprabha, K. Shridhara, K. Nagarajan, H. Sivaramakrishnan, B. Arun
Present study involves the synthesis, characterization, antimalarial and anticancer activities of some novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)- cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated, purified and screened for antimalarial and anticancer activities. A few of the novel compounds were found to possess substantial biological activity and are reasonably potent.
{"title":"Synthesis, Characterization, Antimalarial and Anticancer Activities of\u0000Few New Amino Analogues of 1,4-Naphthoquinone","authors":"S. Sanjay, Shashiprabha, K. Shridhara, K. Nagarajan, H. Sivaramakrishnan, B. Arun","doi":"10.14233/ajomc.2022.ajomc-p372","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p372","url":null,"abstract":"Present study involves the synthesis, characterization, antimalarial and anticancer activities of some novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)- cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated, purified and screened for antimalarial and anticancer activities. A few of the novel compounds were found to possess substantial biological activity and are reasonably potent.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85211679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp235-238
{"title":"To Study the Effect of Unbalancing on Two Overhung Rotors by Vibration Monitoring","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp235-238","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp235-238","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87134500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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