Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00072
M. Allaoui, O. Rahim, D. Hamada, Manel Zaoui-Djelloul Daouadji, B. Labed
The Moringa oleifera (Moringaceae) is one of these important plants, distributed in many tropical and sub-tropical countries, known with its medical uses of high nutritional value it is called the "tree of life". The Composition profile of the dichloromethane extract of the flowers of Moringa oleifera growing in Algerian desert was studied by capillary gas chromatography-mass spectrometry (GC-MS). thirty four Compounds were identified; Within the limits of the applied experimental conditions and by interpreting the mass spectra obtained and comparing it with the mass spectra of the reference materials, we record the possibility of the presence of the following chemical compounds: Hydrocarbons, Organic acids, Esters, Aldehydes Aromatic compounds and Nitrocyclic compounds, which major compounds are : (Z) - (9,17Octadecadienal (100%), Octadecanoic acid (60.4%), Heneicosane (10.186%), (Z)-9 Octadecenoic acid (12.711%), Heptadecanoic acid (13.742%), Hexadecane, 2,6,10,14-tetramethyl (18.988%), Heptadecane (14.866%) and Eicosane (17.535%). Analysis of QSAR descriptor from the results revealed that major constituents of the dichloromethane extract of Moringa olifera (L.) flowers.
{"title":"Chemical composition and QSAR descriptor of the dichloromethane extract of Moringa olifera (L.) flowers","authors":"M. Allaoui, O. Rahim, D. Hamada, Manel Zaoui-Djelloul Daouadji, B. Labed","doi":"10.52711/0974-4150.2022.00072","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00072","url":null,"abstract":"The Moringa oleifera (Moringaceae) is one of these important plants, distributed in many tropical and sub-tropical countries, known with its medical uses of high nutritional value it is called the \"tree of life\". The Composition profile of the dichloromethane extract of the flowers of Moringa oleifera growing in Algerian desert was studied by capillary gas chromatography-mass spectrometry (GC-MS). thirty four Compounds were identified; Within the limits of the applied experimental conditions and by interpreting the mass spectra obtained and comparing it with the mass spectra of the reference materials, we record the possibility of the presence of the following chemical compounds: Hydrocarbons, Organic acids, Esters, Aldehydes Aromatic compounds and Nitrocyclic compounds, which major compounds are : (Z) - (9,17Octadecadienal (100%), Octadecanoic acid (60.4%), Heneicosane (10.186%), (Z)-9 Octadecenoic acid (12.711%), Heptadecanoic acid (13.742%), Hexadecane, 2,6,10,14-tetramethyl (18.988%), Heptadecane (14.866%) and Eicosane (17.535%). Analysis of QSAR descriptor from the results revealed that major constituents of the dichloromethane extract of Moringa olifera (L.) flowers.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81182908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00086
M. M. Eswarudu, B. Kumar, P. Babu
The combination of Ivabradine (IVA) and Metoprolol (MET) was approved by US-FDA for symptomatic treatment of chronic stable angina pectoris. This Review focuses on recent development in analytical methods for IVA and MET. This review article represents the collection and discussion of various analytical methods available in the literature for the determination of IVA and MET individually and combination available in pharmaceutical and biological samples consisting of HPLC, HPTLC, GC, Thermal methods like TGA, DTA, DSC, and hyphenated techniques such as LC-MS, LC-MS/MS, and UPLC-MS/MS. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. The present review article can be effectively explored to conduct future analytical investigation for the estimation of Ivabradine and Metoprolol.
{"title":"A Review of Analytical Methods for the Estimation of Ivabradine and Metoprolol in Pharmaceutical Formulations and Biological Matrices","authors":"M. M. Eswarudu, B. Kumar, P. Babu","doi":"10.52711/0974-4150.2022.00086","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00086","url":null,"abstract":"The combination of Ivabradine (IVA) and Metoprolol (MET) was approved by US-FDA for symptomatic treatment of chronic stable angina pectoris. This Review focuses on recent development in analytical methods for IVA and MET. This review article represents the collection and discussion of various analytical methods available in the literature for the determination of IVA and MET individually and combination available in pharmaceutical and biological samples consisting of HPLC, HPTLC, GC, Thermal methods like TGA, DTA, DSC, and hyphenated techniques such as LC-MS, LC-MS/MS, and UPLC-MS/MS. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. The present review article can be effectively explored to conduct future analytical investigation for the estimation of Ivabradine and Metoprolol.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74946858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00071
Khadra Mokadem, Belfar Mohemed Lakhdar, K. Tumba, Abdulqader Saad Abed, M. Korichi
A linear model based on group-interaction contributions is proposed for the estimation of the freezing temperature (Tf) of ionic liquids (ILs). This property is important for modelling solid-liquid equilibrium and selecting ionic liquids as reaction media among other things. A database of 66 experimental freezing points different ionic liquids was used to obtain all interaction contribution parameters and model constants. The database included various classes of ionic liquids and a wide range of cation and anion groups., with an average absolute relative deviation of 4,09% and a correlation coefficient of 0,93.
{"title":"A Simple Group-Interaction Contribution Method for the Prediction of the Freezing Point of Ionic Liquids","authors":"Khadra Mokadem, Belfar Mohemed Lakhdar, K. Tumba, Abdulqader Saad Abed, M. Korichi","doi":"10.52711/0974-4150.2022.00071","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00071","url":null,"abstract":"A linear model based on group-interaction contributions is proposed for the estimation of the freezing temperature (Tf) of ionic liquids (ILs). This property is important for modelling solid-liquid equilibrium and selecting ionic liquids as reaction media among other things. A database of 66 experimental freezing points different ionic liquids was used to obtain all interaction contribution parameters and model constants. The database included various classes of ionic liquids and a wide range of cation and anion groups., with an average absolute relative deviation of 4,09% and a correlation coefficient of 0,93.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91388516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00082
Bouchareb Hadj, B. Mokhtar, Djedid Mebrouk, Tafer Asma, Mounir Habati, Al-Dujaili A. H.
This work consisted in the preparation and the study of a new stationary phase based on liquid crystals for gas chromatography applications. Most of the synthesized compounds that have the character of liquid crystals in their constitution include aromatic molecules. In addition, there is little work that replaces this type of molecules with heterogeneous molecules that have a liquid crystalline character. This study constitutes an approach for the synthesis of a new molecule azoesters involves a 1,3,4-oxadiazole unit instead of aromatic rings, and which exhibits liquid crystalline characters. A liquid crystal has been prepared and characterized. The thermodynamic characteristics of the n-alkanes for the filled column were studied by reverse gas chromatography. The intermediate products, as well as the mesogens obtained, were characterized by various experimental analysis techniques such as infrared spectrometry (IR) and nuclear magnetic resonance (NMR). The thermal properties of synthesized liquid crystal require the use of DSC technique. Thermodynamic parameters such as enthalpies, partial solution molar entropy and infinite dilution, were determined for the liquid crystal-solvent system. The thermodynamic quantities show that these values depend on the number of carbon atoms of the CL phase terminal substituent. The transition temperatures obtained by gas chromatography are in good agreement with those found by DSC.
{"title":"Comparative Thermal and Thermodynamic Study of Homologous series by Chromatography using Liquid Crystalline Stationary Phase","authors":"Bouchareb Hadj, B. Mokhtar, Djedid Mebrouk, Tafer Asma, Mounir Habati, Al-Dujaili A. H.","doi":"10.52711/0974-4150.2022.00082","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00082","url":null,"abstract":"This work consisted in the preparation and the study of a new stationary phase based on liquid crystals for gas chromatography applications. Most of the synthesized compounds that have the character of liquid crystals in their constitution include aromatic molecules. In addition, there is little work that replaces this type of molecules with heterogeneous molecules that have a liquid crystalline character. This study constitutes an approach for the synthesis of a new molecule azoesters involves a 1,3,4-oxadiazole unit instead of aromatic rings, and which exhibits liquid crystalline characters. A liquid crystal has been prepared and characterized. The thermodynamic characteristics of the n-alkanes for the filled column were studied by reverse gas chromatography. The intermediate products, as well as the mesogens obtained, were characterized by various experimental analysis techniques such as infrared spectrometry (IR) and nuclear magnetic resonance (NMR). The thermal properties of synthesized liquid crystal require the use of DSC technique. Thermodynamic parameters such as enthalpies, partial solution molar entropy and infinite dilution, were determined for the liquid crystal-solvent system. The thermodynamic quantities show that these values depend on the number of carbon atoms of the CL phase terminal substituent. The transition temperatures obtained by gas chromatography are in good agreement with those found by DSC.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83307561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00084
A. Chaudhary, D. Arora, P. Devi
As we know, there is tremendous cases of neuropathic pain seen recently in the world. Due to the toxic effects of drugs used to reduce this severe dysfunction, one can always move towards the herbal products or substances available in nature. Nature has numerous drugs that can be used to cure even severe diseases. One of which is Capsaicin which is available in the Capsicum or pepper. This Capsaicin plays a vital role in the treatment of neuropathic pain. In this article, we will discuss the roles and importance of Capsaicin (Pepper) found in Capsicum in neuropathic pain.
{"title":"A Review on the role of Capsaicin in Neuropathic Pain","authors":"A. Chaudhary, D. Arora, P. Devi","doi":"10.52711/0974-4150.2022.00084","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00084","url":null,"abstract":"As we know, there is tremendous cases of neuropathic pain seen recently in the world. Due to the toxic effects of drugs used to reduce this severe dysfunction, one can always move towards the herbal products or substances available in nature. Nature has numerous drugs that can be used to cure even severe diseases. One of which is Capsaicin which is available in the Capsicum or pepper. This Capsaicin plays a vital role in the treatment of neuropathic pain. In this article, we will discuss the roles and importance of Capsaicin (Pepper) found in Capsicum in neuropathic pain.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76203177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.52711/0974-4150.2022.00083
Y. Marif, Afak Benazzouz, B. Hebbal
In the present study, the feasibility of using single particle Cu and hybrid Cu/Al2O3 nanofluids as heat transfer fluids in a coupled solar parabolic trough collector-heat water storage tank for domestic absorption cooling systems. A computer program based on one dimensional implicit finite difference method and energy balance approach has been developed to investigate the behavior of the studied system under the real climate conditions of a typical summer day in Adrar city, Algeria. The simulation findings reveal that solar parabolic trough collector with small area of 6m² and storage tank of 0.3m3 can ensure higher storage tank temperature able to drive an absorption cooling machine. Solar system with hybrid nanofluid shows superior performance compared to single nanofluid and pure water. Furthermore, the effect of nanoparticle's volume fraction is evaluated. The heat storage tank temperature can attain starting operating chiller temperature more rapidly with small volume fraction equal to 0.2% in the case of Cu-Al2O3/Water hybrid nanofluid.
{"title":"The effect of single and hybrid nanofluids in the performance of Solar Water Heating System","authors":"Y. Marif, Afak Benazzouz, B. Hebbal","doi":"10.52711/0974-4150.2022.00083","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00083","url":null,"abstract":"In the present study, the feasibility of using single particle Cu and hybrid Cu/Al2O3 nanofluids as heat transfer fluids in a coupled solar parabolic trough collector-heat water storage tank for domestic absorption cooling systems. A computer program based on one dimensional implicit finite difference method and energy balance approach has been developed to investigate the behavior of the studied system under the real climate conditions of a typical summer day in Adrar city, Algeria. The simulation findings reveal that solar parabolic trough collector with small area of 6m² and storage tank of 0.3m3 can ensure higher storage tank temperature able to drive an absorption cooling machine. Solar system with hybrid nanofluid shows superior performance compared to single nanofluid and pure water. Furthermore, the effect of nanoparticle's volume fraction is evaluated. The heat storage tank temperature can attain starting operating chiller temperature more rapidly with small volume fraction equal to 0.2% in the case of Cu-Al2O3/Water hybrid nanofluid.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73044915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The importance of Chemometrics Methods in Modeling (in QSAR analysis) of the mathematical model’s study of large datasets of molecules with huge numbers of physicochemical and structural parameters quantitative structure-Toxicity relationship (QSTR) are mainly based on multiple regression analysis in QSAR analysis The study of Least Square in deriving QSTR models for datasets of Quantitative Structure-Toxicity relationship on Log kow (Octanol-water partition coefficient) for 16 Hydrocarbons compounds has been using the software Hyperchem 6.3 for computing descriptors and MINITAB 16 for data modeling. A three -descriptors model [two electronics molecules’ descriptors (QSER descriptor), HOMO (is Highest occupied molecular orbital) and LUMO (Lowest unoccupied molecular orbital), one QSAR descriptor E_H (Hydration Energy) by Least Squares with correlation coefficient r=0.868, S=0.635, R2 = 75.4%, R2ajd=73.7% and Durbin-Watson statistic =1.85277 and graphical analysis by diagram of goodness of fit and line plot. The results statistical of new model after removing the aberrant compounds (Toxicity compounds) shows high Coefficient of correlation r=0.9581, S=0.4316, determination coefficient R2 =91. 8%, ajustemed R2ajd = 89.3%, Durbin-Watson statistic D=2.373, Three explanatory Variable model selected is robust and has good fitness. Two influential compounds detected and important the model and absence aberant compounds of the studied sample.
{"title":"Modeling of Log Kow of a Series of PAHs using Computational Chemistry","authors":"Fatiha Mebarki, Souhaila Meneceur, Abderrhmane Bouafia","doi":"10.52711/0974-4150.2022.00078","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00078","url":null,"abstract":"The importance of Chemometrics Methods in Modeling (in QSAR analysis) of the mathematical model’s study of large datasets of molecules with huge numbers of physicochemical and structural parameters quantitative structure-Toxicity relationship (QSTR) are mainly based on multiple regression analysis in QSAR analysis The study of Least Square in deriving QSTR models for datasets of Quantitative Structure-Toxicity relationship on Log kow (Octanol-water partition coefficient) for 16 Hydrocarbons compounds has been using the software Hyperchem 6.3 for computing descriptors and MINITAB 16 for data modeling. A three -descriptors model [two electronics molecules’ descriptors (QSER descriptor), HOMO (is Highest occupied molecular orbital) and LUMO (Lowest unoccupied molecular orbital), one QSAR descriptor E_H (Hydration Energy) by Least Squares with correlation coefficient r=0.868, S=0.635, R2 = 75.4%, R2ajd=73.7% and Durbin-Watson statistic =1.85277 and graphical analysis by diagram of goodness of fit and line plot. The results statistical of new model after removing the aberrant compounds (Toxicity compounds) shows high Coefficient of correlation r=0.9581, S=0.4316, determination coefficient R2 =91. 8%, ajustemed R2ajd = 89.3%, Durbin-Watson statistic D=2.373, Three explanatory Variable model selected is robust and has good fitness. Two influential compounds detected and important the model and absence aberant compounds of the studied sample.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72870543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.52711/0974-4150.2022.00059
Berra Djamila, Dia Ouahida, Laouini Salah Eddine, Menaceur Souheila
In this research, the aim was to investigate the influence of pH value in the extraction medium on the phytochemical composition and antioxidant activity of Artemisia herba-alba species used in traditional medicine. For this reason, two analytical methods were used (UV-visible spectroscopy, HPLC). Antioxidant properties of the extracts at different pH were estimated by two tests: total antioxidant capacity (TAC) and DPPH free radical scavenging capacity. The results of the evaluation of phenolic compounds showed that the aqueous extracts in a weak acid medium had a high percentage of phenol content, and the highest value for total phenol content was 90.759±1.267mg GAE/g. Whereas, the HPLC analysis indicated the presence of most of the standard phenolic compounds in the majority of the extracts. For antioxidant activity, the best antioxidants reported in extract at pH=6, with a semi-maximal inhibitory concentration (0.151±0,032mg/ml) and a total antioxidant capacity (TAC) of 66.840±0.241mg EAA/g, which indicates that it is effective antioxidant for therapeutic applications.
{"title":"The impact of pH value in the Phenolic content and Antioxidant potential of Medicinal plant extract","authors":"Berra Djamila, Dia Ouahida, Laouini Salah Eddine, Menaceur Souheila","doi":"10.52711/0974-4150.2022.00059","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00059","url":null,"abstract":"In this research, the aim was to investigate the influence of pH value in the extraction medium on the phytochemical composition and antioxidant activity of Artemisia herba-alba species used in traditional medicine. For this reason, two analytical methods were used (UV-visible spectroscopy, HPLC). Antioxidant properties of the extracts at different pH were estimated by two tests: total antioxidant capacity (TAC) and DPPH free radical scavenging capacity. The results of the evaluation of phenolic compounds showed that the aqueous extracts in a weak acid medium had a high percentage of phenol content, and the highest value for total phenol content was 90.759±1.267mg GAE/g. Whereas, the HPLC analysis indicated the presence of most of the standard phenolic compounds in the majority of the extracts. For antioxidant activity, the best antioxidants reported in extract at pH=6, with a semi-maximal inhibitory concentration (0.151±0,032mg/ml) and a total antioxidant capacity (TAC) of 66.840±0.241mg EAA/g, which indicates that it is effective antioxidant for therapeutic applications.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81498775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.52711/0974-4150.2022.00061
Y. Benkrima, A. Souigat, Y. Chaouche, M. E. Soudani, Mohammed Seyf Eddine Bougoffa, N. Mahdadi
In the current paper, we present a systematic calculation based on the Density functional theory (DFT), which aims to highlight the potential effects of doping platinum Pt clusters and the new electronic and light structural characteristics of platinum-infused gold clusters Aun (n= 1-9), so that less energy clusters are selected from the rest of the isomers per cluster size. The most stable structures with the lowest 3D structures starting from n=6. The average length of the bonds between the atoms of each cluster and the binding energy of these clusters is calculated relative to their size. Structural characteristics were studied, discussed and compared with all calculated properties by Gradient Density Approximation (GGA) with the Local Density Approximation (LDA), also highlighted the intensity of calculated cases and comparison of Au2 cluster with PtAu that the grafting of Aun clusters platinum Pt, makes them have characteristics that distinguish them to be qualified in their use of chemical stimulation.
{"title":"Structural and Binding energy of Aun+1 and PtAun (n =1-9) Clusters","authors":"Y. Benkrima, A. Souigat, Y. Chaouche, M. E. Soudani, Mohammed Seyf Eddine Bougoffa, N. Mahdadi","doi":"10.52711/0974-4150.2022.00061","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00061","url":null,"abstract":"In the current paper, we present a systematic calculation based on the Density functional theory (DFT), which aims to highlight the potential effects of doping platinum Pt clusters and the new electronic and light structural characteristics of platinum-infused gold clusters Aun (n= 1-9), so that less energy clusters are selected from the rest of the isomers per cluster size. The most stable structures with the lowest 3D structures starting from n=6. The average length of the bonds between the atoms of each cluster and the binding energy of these clusters is calculated relative to their size. Structural characteristics were studied, discussed and compared with all calculated properties by Gradient Density Approximation (GGA) with the Local Density Approximation (LDA), also highlighted the intensity of calculated cases and comparison of Au2 cluster with PtAu that the grafting of Aun clusters platinum Pt, makes them have characteristics that distinguish them to be qualified in their use of chemical stimulation.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85114761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.52711/0974-4150.2022.00066
Anshul Sharma, Keshav Dhiman, Kamya Goyal, V. Pandit, M. Ashawat, Shammy Jindal
Fusidic acid (FA), derived from the fungus Fusidium coccineum, is an antimicrobial agent that inhibits bacterial protein synthesis by preventing EF-G translocation. This review will provide information regarding the properties of FA, as well as studies on its clinical efficacy in skin and soft-tissue infections (SSTIs). FA has been used for treatment of infection caused by gram- positive microorganism. FA cream or ointment are clinically effective and shown minimum adverse reaction when used in SSTIs two or three times regularly. The analytical methods which describe the presence of FA in biological samples and pharmaceutical formulations are reviewed in this article. High-performance liquid chromatography has been widely used analytical method in the analysis of FA, as it can reduce the cost as well as time of analysis. This review also includes the information regarding the randomised trials which investigates the clinical efficacy of fusidic acid in dermatology in comparative trials that were discovered.
{"title":"Fusidic Acid: A Therapeutic Review","authors":"Anshul Sharma, Keshav Dhiman, Kamya Goyal, V. Pandit, M. Ashawat, Shammy Jindal","doi":"10.52711/0974-4150.2022.00066","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00066","url":null,"abstract":"Fusidic acid (FA), derived from the fungus Fusidium coccineum, is an antimicrobial agent that inhibits bacterial protein synthesis by preventing EF-G translocation. This review will provide information regarding the properties of FA, as well as studies on its clinical efficacy in skin and soft-tissue infections (SSTIs). FA has been used for treatment of infection caused by gram- positive microorganism. FA cream or ointment are clinically effective and shown minimum adverse reaction when used in SSTIs two or three times regularly. The analytical methods which describe the presence of FA in biological samples and pharmaceutical formulations are reviewed in this article. High-performance liquid chromatography has been widely used analytical method in the analysis of FA, as it can reduce the cost as well as time of analysis. This review also includes the information regarding the randomised trials which investigates the clinical efficacy of fusidic acid in dermatology in comparative trials that were discovered.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82664843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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