Pub Date : 2023-01-01DOI: 10.4103/1995-7645.368022
N. Çelik, E. Laloğlu, H. Aslan
Objective: To present platelet large cell ratio (P-LCR), reticulocyte, and immature reticulocyte fraction (IRF) values as novel parameters in diagnosis and response to treatment in patients developing sacroiliitis. Methods: Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination (Wright) or Brucella Coombs agglutination test titers ≥1:160 were included in the study. Two groups were established, one developing sacroiliitis and another with no sacroiliitis development. P-LCR, reticulocyte, and IRF levels were measured using a Sysmex XN-9000 device (Japan). These were then compared between the two groups. Results: Reticulocyte (P=0.037) and IRF (P=0.026) levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group, while P-LCR (P=0.003) levels were significantly higher. P-LCR had the most powerful correlation with sacroiliitis development. Significant negative correlation was observed between reticulocyte, IRF levels and sacroiliitis. Conclusions: Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis, while low reticulocyte and IRF levels secondary to bone marrow involvement were detected. These three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in brucellosis. These are presented as inexpensive, and easily accessible novel parameters.
{"title":"Novel markers in predicting Brucella sacroiliitis: The platelet large cell ratio and basal immature reticulocyte fraction","authors":"N. Çelik, E. Laloğlu, H. Aslan","doi":"10.4103/1995-7645.368022","DOIUrl":"https://doi.org/10.4103/1995-7645.368022","url":null,"abstract":"Objective: To present platelet large cell ratio (P-LCR), reticulocyte, and immature reticulocyte fraction (IRF) values as novel parameters in diagnosis and response to treatment in patients developing sacroiliitis. Methods: Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination (Wright) or Brucella Coombs agglutination test titers ≥1:160 were included in the study. Two groups were established, one developing sacroiliitis and another with no sacroiliitis development. P-LCR, reticulocyte, and IRF levels were measured using a Sysmex XN-9000 device (Japan). These were then compared between the two groups. Results: Reticulocyte (P=0.037) and IRF (P=0.026) levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group, while P-LCR (P=0.003) levels were significantly higher. P-LCR had the most powerful correlation with sacroiliitis development. Significant negative correlation was observed between reticulocyte, IRF levels and sacroiliitis. Conclusions: Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis, while low reticulocyte and IRF levels secondary to bone marrow involvement were detected. These three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in brucellosis. These are presented as inexpensive, and easily accessible novel parameters.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"16 1","pages":"39 - 44"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41857256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.359790
M. Vibhu, Meena Amit, S. Smita
Rationale: Though cutaneous tuberculosis accounts for a small proportion of all tuberculosis cases, it becomes an important health issue considering its high prevalence in tropical countries. Due to its myriad clinical manifestations, it becomes difficult to diagnose and may pose a great diagnostic dilemma. Patient concerns: A 17-year-old male complaint of ulcerproliferative lesion on the left lower leg for 5 years. There was no history suggestive of tuberculosis. On cutaneous examination, single well-defined erosiocrustive plaque of size 14 cm × 13 cm with yellowish adherent crust presented over the left lower leg. The underlying surface shows ulceration after removing the crust. Diagnosis: Ulcerative Lupus vulgaris. Interventions: Anti-tubercular drug therapy (isoniazid, rifampicin, pyrazinamide and ethambutol). Outcomes: Lesion showed dramatic improvement after one month of anti-tubercular therapy. Lessons: Dermatologists should be aware of variable clinical presentations of cutaneous tuberculosis so as to diagnose it timely and correctly.
{"title":"Diagnostic dilemma in a patient with chronic non–healing ulcer on leg: A case report","authors":"M. Vibhu, Meena Amit, S. Smita","doi":"10.4103/1995-7645.359790","DOIUrl":"https://doi.org/10.4103/1995-7645.359790","url":null,"abstract":"Rationale: Though cutaneous tuberculosis accounts for a small proportion of all tuberculosis cases, it becomes an important health issue considering its high prevalence in tropical countries. Due to its myriad clinical manifestations, it becomes difficult to diagnose and may pose a great diagnostic dilemma. Patient concerns: A 17-year-old male complaint of ulcerproliferative lesion on the left lower leg for 5 years. There was no history suggestive of tuberculosis. On cutaneous examination, single well-defined erosiocrustive plaque of size 14 cm × 13 cm with yellowish adherent crust presented over the left lower leg. The underlying surface shows ulceration after removing the crust. Diagnosis: Ulcerative Lupus vulgaris. Interventions: Anti-tubercular drug therapy (isoniazid, rifampicin, pyrazinamide and ethambutol). Outcomes: Lesion showed dramatic improvement after one month of anti-tubercular therapy. Lessons: Dermatologists should be aware of variable clinical presentations of cutaneous tuberculosis so as to diagnose it timely and correctly.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"568 - 570"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48674897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.364003
D. Sharma, Ankita Sharma, Birbal Singh, S. Sushanth Kumar, S. Verma
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.
{"title":"Neglected scrub typhus: An updated review with a focus on omics technologies","authors":"D. Sharma, Ankita Sharma, Birbal Singh, S. Sushanth Kumar, S. Verma","doi":"10.4103/1995-7645.364003","DOIUrl":"https://doi.org/10.4103/1995-7645.364003","url":null,"abstract":"Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"531 - 541"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48632533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.364001
Lee Siew-Keah, K. Hann, S. Hoe, Lai En, Lim Chin, Master Chan, Tee Kang, Chua Ang-Lim
Objective: To investigate the knowledge, attitude, and practice levels and perceived barriers towards healthy living to prevent hypertension among young adults in Malaysia. Methods: Adults aged 18-25 years reside in Malaysia were recruited via convenience sampling. Sociodemographic characteristics, medical knowledge on hypertension (K1), knowledge (K), attitude (A), practice (P) and perceived barriers in practising healthy living to prevent hypertension were assessed. Average scores were categorised into good (80%-100%), upper-moderate (70%-79%), lower-moderate (60%-69%) and poor (<60%). Multivariate analysis was performed to test the difference and relationship of variables. Pearson correlation test was used to test the association of two continuous variables. Results: A total of 1 218 respondents participated in this survey. The mean score of K1 was 54.1%, while the knowledge, attitude, and practice towards healthy living were 82.7%, 78.2%and 68.5% respectively. The prevalence of high salt intake, high fat intakes, low fibre intake, sedentary lifestyle and lack of annual health screening was 83.2%, 81.4%, 70.3%, and 73.2%, respectively. Abnormal BMI was associated with low P scores, while lower socio-economic status, unawareness of self-blood pressure reading and those without family history of hypertension were associated with lower scores in K1, K, A, and P. K1, K, A and P are significantly inter-related. The main perceived barriers included self-proclaimed good fit status, frequent consumption of out-of-home food, and addiction to high salt/fat food. Conclusions: The national strategies for health management should be prioritized in reducing salt and fat, promoting annual health screening, physical activities and fibre intake in this age group.
{"title":"Awareness and perceived barriers in practicing healthy living to prevent hypertension among young adults in Malaysia","authors":"Lee Siew-Keah, K. Hann, S. Hoe, Lai En, Lim Chin, Master Chan, Tee Kang, Chua Ang-Lim","doi":"10.4103/1995-7645.364001","DOIUrl":"https://doi.org/10.4103/1995-7645.364001","url":null,"abstract":"Objective: To investigate the knowledge, attitude, and practice levels and perceived barriers towards healthy living to prevent hypertension among young adults in Malaysia. Methods: Adults aged 18-25 years reside in Malaysia were recruited via convenience sampling. Sociodemographic characteristics, medical knowledge on hypertension (K1), knowledge (K), attitude (A), practice (P) and perceived barriers in practising healthy living to prevent hypertension were assessed. Average scores were categorised into good (80%-100%), upper-moderate (70%-79%), lower-moderate (60%-69%) and poor (<60%). Multivariate analysis was performed to test the difference and relationship of variables. Pearson correlation test was used to test the association of two continuous variables. Results: A total of 1 218 respondents participated in this survey. The mean score of K1 was 54.1%, while the knowledge, attitude, and practice towards healthy living were 82.7%, 78.2%and 68.5% respectively. The prevalence of high salt intake, high fat intakes, low fibre intake, sedentary lifestyle and lack of annual health screening was 83.2%, 81.4%, 70.3%, and 73.2%, respectively. Abnormal BMI was associated with low P scores, while lower socio-economic status, unawareness of self-blood pressure reading and those without family history of hypertension were associated with lower scores in K1, K, A, and P. K1, K, A and P are significantly inter-related. The main perceived barriers included self-proclaimed good fit status, frequent consumption of out-of-home food, and addiction to high salt/fat food. Conclusions: The national strategies for health management should be prioritized in reducing salt and fat, promoting annual health screening, physical activities and fibre intake in this age group.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"542 - 550"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48419174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.364002
Narges Hamedani, M. Pirestani, A. Dalimi
Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findings, and laboratory data were collected. Formalin-fixed, paraffin-embedded and fresh tissue samples of 175 cystic echinococcosis patients were evaluated for molecular characterization. The samples’ isolated DNA was used to amplify cytochrome c oxidase I and NADH dehydrogenase subunit I genes. Also, the morphological features of fresh samples were examined. Results: In total, 175 patients with a mean age of 45 (9-98) years were admitted to Tehran’s hospitals diagnosed with cystic echinococcosis. Moreover, the highest (26.9%) and the lowest (2.9%) prevalence of cystic echinococcosis cases were in the 16-30 and 1-15 years range, respectively. Male/female ratio was 0.96 (49.1% vs. 50.9%). The liver was affected in 92 patients (52.6%), and two or more organs were infected in 7 patients (4.0%). The cysts’ diameter varied from 1 to 25 cm, and 96.0% of the patients had a single hydatid cyst. All patients underwent radical surgery and the PAIR technique was applied for all cases. No significant difference was observed between the protoscolex hooks of pulmonary and hepatic cysts. G1-G3 had the highest percentage (99.4%) over other identified G6 genotypes (0.6%). Conclusions: The sheep-dog cycle plays an important role in transmitting the human cystic echinococcosis infection in Tehran.
{"title":"Clinical and molecular features of human cystic echinococcosis in Tehran, Iran, 2011-2019","authors":"Narges Hamedani, M. Pirestani, A. Dalimi","doi":"10.4103/1995-7645.364002","DOIUrl":"https://doi.org/10.4103/1995-7645.364002","url":null,"abstract":"Objective: To evaluate the clinical and molecular features of human cystic echinococcosis in Tehran, Iran. Methods: In this cross-sectional study, all human cystic echinococcosis patients admitted to Tehran’s hospitals from 2011 to 2019 were enrolled, and demographic characteristics, clinical findings, and laboratory data were collected. Formalin-fixed, paraffin-embedded and fresh tissue samples of 175 cystic echinococcosis patients were evaluated for molecular characterization. The samples’ isolated DNA was used to amplify cytochrome c oxidase I and NADH dehydrogenase subunit I genes. Also, the morphological features of fresh samples were examined. Results: In total, 175 patients with a mean age of 45 (9-98) years were admitted to Tehran’s hospitals diagnosed with cystic echinococcosis. Moreover, the highest (26.9%) and the lowest (2.9%) prevalence of cystic echinococcosis cases were in the 16-30 and 1-15 years range, respectively. Male/female ratio was 0.96 (49.1% vs. 50.9%). The liver was affected in 92 patients (52.6%), and two or more organs were infected in 7 patients (4.0%). The cysts’ diameter varied from 1 to 25 cm, and 96.0% of the patients had a single hydatid cyst. All patients underwent radical surgery and the PAIR technique was applied for all cases. No significant difference was observed between the protoscolex hooks of pulmonary and hepatic cysts. G1-G3 had the highest percentage (99.4%) over other identified G6 genotypes (0.6%). Conclusions: The sheep-dog cycle plays an important role in transmitting the human cystic echinococcosis infection in Tehran.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"558 - 567"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42331980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.361856
E. Ornos, J. G. D. Dela Rosa, J. G. Solidum, Jervy P. Garcia, Erika P. Ong, R. Valenzuela, O. Tantengco
{"title":"Quality of monkeypox information in Wikipedia across multiple languages","authors":"E. Ornos, J. G. D. Dela Rosa, J. G. Solidum, Jervy P. Garcia, Erika P. Ong, R. Valenzuela, O. Tantengco","doi":"10.4103/1995-7645.361856","DOIUrl":"https://doi.org/10.4103/1995-7645.361856","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"571 - 572"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43923768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.364004
B. Akbeyaz, A. Karaaslan, C. Çetin, M. Köle, Z. Altaş, Y. Akın
Objective: To examine the effect of the COVID-19 virus, especially the Omicron variant, on hematological parameters of hospitalized pediatric patients during the COVID-19 pandemic. Methods: Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr. Lütfi Kirdar City Hospital in Istanbul, Turkey, between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics, SARS-CoV-2 infection polymerase chain reaction (PCR) test results, reverse-transcriptase (RT)-PCR for other respiratory agents, duration of hospital stay, and hematological and biochemical laboratory findings. Results: Out of 467 children with a confirmed diagnosis of SARS-CoV-2 infection, 94 (20.1%) had Omicron infection and 373 (79.9%) were infected with other variants; the Omicron group had younger patients than the remaining samples (P<0.001). The most frequent clinical symptoms in all children were cough (53.5%) and fever (32.3%), followed by vomiting (20.8%). Lung involvement in the Omicron group (10.6%) was significantly lower than in the remaining samples (29.8%) (P<0.001). Hemoglobin and lymphocyte levels were lower in the Omicron-infected group (both P<0.001), while prothrombin time, activated partial thromboplastin time, international normalized ratio, and D-dimer levels were significantly higher in this group (P<0.001, P<0.001, P<0.001, and P=0.023, respectively). In terms of lung involvement, those with lung involvement were significantly older (P<0.001). Conclusions: Although lung involvement was less common with Omicron infection, this group had greater hematological system involvement, such as anemia, lymphopenia, D-dimer elevation, and coagulation disorders.
{"title":"Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul","authors":"B. Akbeyaz, A. Karaaslan, C. Çetin, M. Köle, Z. Altaş, Y. Akın","doi":"10.4103/1995-7645.364004","DOIUrl":"https://doi.org/10.4103/1995-7645.364004","url":null,"abstract":"Objective: To examine the effect of the COVID-19 virus, especially the Omicron variant, on hematological parameters of hospitalized pediatric patients during the COVID-19 pandemic. Methods: Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr. Lütfi Kirdar City Hospital in Istanbul, Turkey, between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics, SARS-CoV-2 infection polymerase chain reaction (PCR) test results, reverse-transcriptase (RT)-PCR for other respiratory agents, duration of hospital stay, and hematological and biochemical laboratory findings. Results: Out of 467 children with a confirmed diagnosis of SARS-CoV-2 infection, 94 (20.1%) had Omicron infection and 373 (79.9%) were infected with other variants; the Omicron group had younger patients than the remaining samples (P<0.001). The most frequent clinical symptoms in all children were cough (53.5%) and fever (32.3%), followed by vomiting (20.8%). Lung involvement in the Omicron group (10.6%) was significantly lower than in the remaining samples (29.8%) (P<0.001). Hemoglobin and lymphocyte levels were lower in the Omicron-infected group (both P<0.001), while prothrombin time, activated partial thromboplastin time, international normalized ratio, and D-dimer levels were significantly higher in this group (P<0.001, P<0.001, P<0.001, and P=0.023, respectively). In terms of lung involvement, those with lung involvement were significantly older (P<0.001). Conclusions: Although lung involvement was less common with Omicron infection, this group had greater hematological system involvement, such as anemia, lymphopenia, D-dimer elevation, and coagulation disorders.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"551 - 557"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45704814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4103/1995-7645.364006
Ana Caroline Evangelista, Maria Eduarda Bandeira, L. D. de Sena, William Paula, Marli do Cupertino, A. Gomes, R. Siqueira-Batista
{"title":"New variola (mpox) in Brazil: Epidemiological update and perspectives","authors":"Ana Caroline Evangelista, Maria Eduarda Bandeira, L. D. de Sena, William Paula, Marli do Cupertino, A. Gomes, R. Siqueira-Batista","doi":"10.4103/1995-7645.364006","DOIUrl":"https://doi.org/10.4103/1995-7645.364006","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"525 - 528"},"PeriodicalIF":3.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47478189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.4103/1995-7645.361853
F. Fakili, P. Çetinkaya, Oya Baydar, S. Barış, N. Kokturk, S. Kul, O. Karcıoğlu, P. Yıldız, I. Irmak, Y. Sekibag, Emel Azak, Sait Mulamahmutoglu, Ç. Çuhadaroglu, B. Kerget, B. Ketencioglu, H. Ozger, G. Ozkan, Zeynep Ture, M. Erçelik, T. Çiftçi, O. Alici, E. Temel, O. Ataoglu, N. Kose, M. Tor, Gulşah Gunluoglu, S. Altın, O. Ozturk, P. Gulhan, I. Basyigit, H. Boyacı, I. Oguzulgen, S. Borekci, B. Gemicioğlu, I. Hanta, H. Okur, Gulseren Sagcan, M. Akgun, A. Kalyoncu, O. Itil, H. Bayram
Objective: To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society (TTD)-TURCOVID study. Methods: In this retrospective cohort study, we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study, and 1 112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the study. All causes of death after COVID-19 discharge were recorded. Results: The mean age of the patients was (51.07±16.93) years, with 57.6% male patients. In the cohort group, 89.1% of COVID-19 treatment locations were hospital wards, 3.6% were intensive care units (ICUs), and 7.2% were community outpatients. In the longterm follow-up, the in-hospital mortality rate was 3.6% (95% CI 2.64.8), the post-discharge mortality rate was 2.8% (95% CI 1.9-3.9), and the total mortality was 6.3% (95% CI 5.0-7.8). After discharge, 63.3% of mortality overall occurred during the first six months. Mortality rates in post-discharge follow-ups were 12.7% (95% CI 8.0-30.6) in cancer patients, 10.8% (95% CI 6.3-22.9) in chronic obstructive pulmonary disease patients, 11.1% (95% CI 4.4-22.7) in heart failure patients, 7.8 (95% CI 3.8-14.3) in atherosclerotic heart disease patients, and 2.3% (95% CI 0.8-5.6) in diabetes mellitus patients. In smokers/ex-smokers, the all-mortality rates were higher than in non-smokers. Conclusions: This multicenter study showed that patients over 65 years of age, males, former/active smoker, ICU stay, lung, heart disease, and malignancy should be followed up for at least the first six months after discharge due to COVID-19.
{"title":"Post−discharge mortality in the first wave of COVID−19 in Turkey","authors":"F. Fakili, P. Çetinkaya, Oya Baydar, S. Barış, N. Kokturk, S. Kul, O. Karcıoğlu, P. Yıldız, I. Irmak, Y. Sekibag, Emel Azak, Sait Mulamahmutoglu, Ç. Çuhadaroglu, B. Kerget, B. Ketencioglu, H. Ozger, G. Ozkan, Zeynep Ture, M. Erçelik, T. Çiftçi, O. Alici, E. Temel, O. Ataoglu, N. Kose, M. Tor, Gulşah Gunluoglu, S. Altın, O. Ozturk, P. Gulhan, I. Basyigit, H. Boyacı, I. Oguzulgen, S. Borekci, B. Gemicioğlu, I. Hanta, H. Okur, Gulseren Sagcan, M. Akgun, A. Kalyoncu, O. Itil, H. Bayram","doi":"10.4103/1995-7645.361853","DOIUrl":"https://doi.org/10.4103/1995-7645.361853","url":null,"abstract":"Objective: To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society (TTD)-TURCOVID study. Methods: In this retrospective cohort study, we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study, and 1 112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the study. All causes of death after COVID-19 discharge were recorded. Results: The mean age of the patients was (51.07±16.93) years, with 57.6% male patients. In the cohort group, 89.1% of COVID-19 treatment locations were hospital wards, 3.6% were intensive care units (ICUs), and 7.2% were community outpatients. In the longterm follow-up, the in-hospital mortality rate was 3.6% (95% CI 2.64.8), the post-discharge mortality rate was 2.8% (95% CI 1.9-3.9), and the total mortality was 6.3% (95% CI 5.0-7.8). After discharge, 63.3% of mortality overall occurred during the first six months. Mortality rates in post-discharge follow-ups were 12.7% (95% CI 8.0-30.6) in cancer patients, 10.8% (95% CI 6.3-22.9) in chronic obstructive pulmonary disease patients, 11.1% (95% CI 4.4-22.7) in heart failure patients, 7.8 (95% CI 3.8-14.3) in atherosclerotic heart disease patients, and 2.3% (95% CI 0.8-5.6) in diabetes mellitus patients. In smokers/ex-smokers, the all-mortality rates were higher than in non-smokers. Conclusions: This multicenter study showed that patients over 65 years of age, males, former/active smoker, ICU stay, lung, heart disease, and malignancy should be followed up for at least the first six months after discharge due to COVID-19.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":"15 1","pages":"479 - 484"},"PeriodicalIF":3.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41834775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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