Pub Date : 2023-11-01DOI: 10.4103/1995-7645.388386
Dan Luo, Zhihao Zhao, Caizheng Li, Wenjun Zhu, Wei Zhou, Lirong He, Huifeng Yan, Qiaoli Su
Objective: To explore the association between the Lung Immune Prognostic Index (LIPI) and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease (IIM-ILD). Methods: Patients who were diagnosed with IIM-ILD at West China Hospital, Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on LIPI. Univariable and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients' mortality. Results: A total of 1116 patients were screened, and 830 were included in this study. The multivariable Cox analysis showed that, compared with patients with poor LIPI, the hazard ratio (HR) for all-cause 1-year mortality was 0.22 (95% CI 0.05-0.93, P=0.04) for patients in the good LIPI group (LDH<250 IU/L and dNLR<3). After excluding patients lost to follow-up within one year, a similar result was found for LIPI (HR 0.20, 95% CI 0.05-0.86; P=0.03). Conclusions: Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with IIM-ILD. This easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD.
{"title":"Association between the Lung Immune Prognostic Index and mortality in patients with idiopathic inflammatory myopathy-associated interstitial lung disease","authors":"Dan Luo, Zhihao Zhao, Caizheng Li, Wenjun Zhu, Wei Zhou, Lirong He, Huifeng Yan, Qiaoli Su","doi":"10.4103/1995-7645.388386","DOIUrl":"https://doi.org/10.4103/1995-7645.388386","url":null,"abstract":"Objective: To explore the association between the Lung Immune Prognostic Index (LIPI) and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease (IIM-ILD). Methods: Patients who were diagnosed with IIM-ILD at West China Hospital, Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on LIPI. Univariable and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients' mortality. Results: A total of 1116 patients were screened, and 830 were included in this study. The multivariable Cox analysis showed that, compared with patients with poor LIPI, the hazard ratio (HR) for all-cause 1-year mortality was 0.22 (95% CI 0.05-0.93, P=0.04) for patients in the good LIPI group (LDH<250 IU/L and dNLR<3). After excluding patients lost to follow-up within one year, a similar result was found for LIPI (HR 0.20, 95% CI 0.05-0.86; P=0.03). Conclusions: Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with IIM-ILD. This easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.4103/1995-7645.390165
AbdulRahman Muthanna, N. Baharin, Mohd Nasir Desa, N. Dzaraly, Mohammad Noor Azmai, Syafinaz Amin-Nordin
Objective: To determine the prevalence of group B Streptococcus (GBS) isolated from non-pregnant adults from seven major hospitals in Peninsular Malaysia; the incidence, case-fatality ratio, antimicrobial susceptibility patterns, serotype, genotype and distribution of the GBS virulence and pili genes are also investigated. Methods: This multicentre, prospective, observational study is conducted in seven major tertiary hospitals in Malaysia among non-pregnant adults. Simultaneously, a retrospective study is conducted in the selected hospitals with similar approaches. GBS isolates are subjected to phenotyping, serotyping by multiplex PCR, antimicrobial susceptibility testing and PCR-detection of GBS virulence and pilus genes. Seven housekeeping genes are amplified and sequenced for multi-locus sequence typing. Discussion: Findings from the study may contribute to the management of clinical practice to diagnose and prevent GBS related diseases in a timely manner. Prudent use of antibiotics is encouraged by monitoring antimicrobial resistance.
{"title":"Disease burden, antimicrobial resistance and molecular characterization of invasive group B Streptococcus among non-pregnant adults in Malaysia: A protocol study","authors":"AbdulRahman Muthanna, N. Baharin, Mohd Nasir Desa, N. Dzaraly, Mohammad Noor Azmai, Syafinaz Amin-Nordin","doi":"10.4103/1995-7645.390165","DOIUrl":"https://doi.org/10.4103/1995-7645.390165","url":null,"abstract":"Objective: To determine the prevalence of group B Streptococcus (GBS) isolated from non-pregnant adults from seven major hospitals in Peninsular Malaysia; the incidence, case-fatality ratio, antimicrobial susceptibility patterns, serotype, genotype and distribution of the GBS virulence and pili genes are also investigated. Methods: This multicentre, prospective, observational study is conducted in seven major tertiary hospitals in Malaysia among non-pregnant adults. Simultaneously, a retrospective study is conducted in the selected hospitals with similar approaches. GBS isolates are subjected to phenotyping, serotyping by multiplex PCR, antimicrobial susceptibility testing and PCR-detection of GBS virulence and pilus genes. Seven housekeeping genes are amplified and sequenced for multi-locus sequence typing. Discussion: Findings from the study may contribute to the management of clinical practice to diagnose and prevent GBS related diseases in a timely manner. Prudent use of antibiotics is encouraged by monitoring antimicrobial resistance.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.4103/1995-7645.390166
Rajendra Prasad Rao, L. Mohanty, Amit Jajodia, Santosh Sharma
{"title":"Myocarditis in scrub typhus-An uncommon presentation","authors":"Rajendra Prasad Rao, L. Mohanty, Amit Jajodia, Santosh Sharma","doi":"10.4103/1995-7645.390166","DOIUrl":"https://doi.org/10.4103/1995-7645.390166","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139300227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The periodic outbreak of mosquito-borne diseases like dengue fever, zika fever, and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological system. Due to the lack of therapeutic measures, preventive treatments or vaccines against pathogens, insecticide resistance eventually lead the research focus towards novel technological applications in mosquito management. Nanomaterials with ovicidal, larvicidal, adulticidal, and repellent properties for controlling mosquito vectors are under research. A literature search was carried out for advancements in nanomaterials, insecticides, and mosquito control in PubMed/MEDLINE, Scopus, Google Scholar, ScienceDirect, and Web of Science. This paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases, in vivo and in vitro toxicity evaluation against mosquito species, mode of action, effect on non-target organisms, and ecological risks. Organic and inorganic materials that provide controlled release, target delivery, less dosage, prolonged efficacy, a reduction in the use of organic solvents and emulsifiers, and minimum pollution to the environment have already been explored. Indeed, further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.
登革热、寨卡热和黄热病等蚊媒疾病在世界各地的周期性爆发，凸显了针对生物系统的有效蚊虫控制方法的必要性。由于缺乏针对病原体的治疗措施、预防治疗或疫苗，杀虫剂的抗药性最终导致研究重点转向蚊虫管理方面的新型技术应用。目前正在研究具有杀卵、杀幼虫剂、杀成虫和驱避特性的纳米材料，以控制蚊虫媒介。我们在 PubMed/MEDLINE、Scopus、Google Scholar、ScienceDirect 和 Web of Science 中对纳米材料、杀虫剂和蚊虫控制方面的进展进行了文献检索。本文旨在深入探讨与蚊媒疾病相关的各种纳米材料、对蚊子物种的体内和体外毒性评估、作用模式、对非目标生物的影响以及生态风险。人们已经探索了能够控释、靶向给药、减少用量、延长药效、减少有机溶剂和乳化剂的使用以及将环境污染降到最低的有机和无机材料。事实上，在商业化之前，应进一步研究纳米材料在灭蚊应用中的生态风险和经济可行性。
{"title":"Applications of nanomaterials in mosquito vector control: A review","authors":"Sahadiya Mandodan, Aneha Kunnikuruvan, Bhagyashree Bora, Hemaladkshmi Padmanaban, Abhisubesh Vijayakumar, Kakhuangailiu Gangmei, Manikandan Sivaprakasam, Jibi Lukose, Mathivanan Ashokkumar, Vijayalakshmi Krishnamoorthy, S. Poopathi","doi":"10.4103/1995-7645.390164","DOIUrl":"https://doi.org/10.4103/1995-7645.390164","url":null,"abstract":"The periodic outbreak of mosquito-borne diseases like dengue fever, zika fever, and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological system. Due to the lack of therapeutic measures, preventive treatments or vaccines against pathogens, insecticide resistance eventually lead the research focus towards novel technological applications in mosquito management. Nanomaterials with ovicidal, larvicidal, adulticidal, and repellent properties for controlling mosquito vectors are under research. A literature search was carried out for advancements in nanomaterials, insecticides, and mosquito control in PubMed/MEDLINE, Scopus, Google Scholar, ScienceDirect, and Web of Science. This paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases, in vivo and in vitro toxicity evaluation against mosquito species, mode of action, effect on non-target organisms, and ecological risks. Organic and inorganic materials that provide controlled release, target delivery, less dosage, prolonged efficacy, a reduction in the use of organic solvents and emulsifiers, and minimum pollution to the environment have already been explored. Indeed, further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.4103/1995-7645.386256
Jie Liu, Wanqing Zheng, Zhen Liu, Xiujing Jiang
Objective: To determine the impact of major disease epidemics on pharmaceutical manufacturing firms' Research & Development (R&D) investments and economic consequences. Methods: The sample consists of 1 582 firm-year observations from 2009 to 2022 in China, of which, 26.6% of pharmaceutical companies are involved in the diagnosis and treatment of prevalent diseases. Linear models using R&D investments, patent applications, operating performances and stock returns as dependent variables are constructed separately to examine the response of pharmaceutical companies to disease epidemics and the resulting economic consequences. Results: The prevalence of five major diseases led to a 17.5% increase in the amount of R&D investment and an 87.8% rise in the ratio of R&D investment to total assets by disease-related pharmaceutical companies, compared to unrelated pharmaceutical companies. Further evidence indicated that the patent applications for disease-related firms increased by 44.3% relative to unrelated firms after the epidemics. Though the impacts of the epidemics on firms' operating performances were insignificant in the short term, a major disease epidemic was associated with an increase in stock returns of 67.4% and 44.6%, respectively, as measured by the capital asset pricing model and Fama-French five-factor model. Additional analysis revealed that the impacts of the epidemics on R&D investments and patent applications were more pronounced for non-state-owned enterprises than state-owned enterprises. Conclusions: This study demonstrates that disease-related pharmaceutical firms respond to the disease epidemics through increasing R&D investment. More patent applications and higher market value are the main gains from the firms' increased investments in R&D following the epidemic, rather than the improvements of short-term operating performances.
{"title":"Impact of H1N1, H7N9, ASFV, dengue virus and COVID-19 on pharmaceutical manufacturing firms' R&D investments and economic consequences: Evidence from China","authors":"Jie Liu, Wanqing Zheng, Zhen Liu, Xiujing Jiang","doi":"10.4103/1995-7645.386256","DOIUrl":"https://doi.org/10.4103/1995-7645.386256","url":null,"abstract":"Objective: To determine the impact of major disease epidemics on pharmaceutical manufacturing firms' Research & Development (R&D) investments and economic consequences. Methods: The sample consists of 1 582 firm-year observations from 2009 to 2022 in China, of which, 26.6% of pharmaceutical companies are involved in the diagnosis and treatment of prevalent diseases. Linear models using R&D investments, patent applications, operating performances and stock returns as dependent variables are constructed separately to examine the response of pharmaceutical companies to disease epidemics and the resulting economic consequences. Results: The prevalence of five major diseases led to a 17.5% increase in the amount of R&D investment and an 87.8% rise in the ratio of R&D investment to total assets by disease-related pharmaceutical companies, compared to unrelated pharmaceutical companies. Further evidence indicated that the patent applications for disease-related firms increased by 44.3% relative to unrelated firms after the epidemics. Though the impacts of the epidemics on firms' operating performances were insignificant in the short term, a major disease epidemic was associated with an increase in stock returns of 67.4% and 44.6%, respectively, as measured by the capital asset pricing model and Fama-French five-factor model. Additional analysis revealed that the impacts of the epidemics on R&D investments and patent applications were more pronounced for non-state-owned enterprises than state-owned enterprises. Conclusions: This study demonstrates that disease-related pharmaceutical firms respond to the disease epidemics through increasing R&D investment. More patent applications and higher market value are the main gains from the firms' increased investments in R&D following the epidemic, rather than the improvements of short-term operating performances.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136152142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.4103/1995-7645.388029
Emily Schembri, Angus J D Campbell, Juan Pablo Villanueva-Cabezas
Objective: To identify and discuss on-farm management practices linked to bacterial zoonosis risk in smallholder dairy farmers in South Asia. Methods: This scoping review was conducted as per the PRISMA-ScR guidelines. Five hundred and two publications were retrieved from five online databases using a comprehensive search strategy. Studies were selected if they discussed a farm management practice which impacted human health within a South Asian country. Results: Twenty-two studies were included. Seven management practices relevant to farmers, livestock and their shared environment were identified including raw milk consumption, farm hygiene management, personal protective equipment uses, animal vaccination, cleaning udders, hand washing and disposal of afterbirth materials. Preventive practices were found to be utilized at lower frequencies compared to risk increasing practices. Awareness of bacterial zoonoses is particularly low within the region. Conclusions: Based on the results of this review, it was determined that improving farmer awareness of bacterial zoonotic diseases may favor several of the presented leverage points within the South Asian smallholder dairy system. Relying on formal school education to improve this awareness may not solve this problem, instead, more focus on accessible and affordable zoonoses education and farming programs is required.
{"title":"South Asian dairy smallholders: A scoping review of practices and zoonoses","authors":"Emily Schembri, Angus J D Campbell, Juan Pablo Villanueva-Cabezas","doi":"10.4103/1995-7645.388029","DOIUrl":"https://doi.org/10.4103/1995-7645.388029","url":null,"abstract":"Objective: To identify and discuss on-farm management practices linked to bacterial zoonosis risk in smallholder dairy farmers in South Asia. Methods: This scoping review was conducted as per the PRISMA-ScR guidelines. Five hundred and two publications were retrieved from five online databases using a comprehensive search strategy. Studies were selected if they discussed a farm management practice which impacted human health within a South Asian country. Results: Twenty-two studies were included. Seven management practices relevant to farmers, livestock and their shared environment were identified including raw milk consumption, farm hygiene management, personal protective equipment uses, animal vaccination, cleaning udders, hand washing and disposal of afterbirth materials. Preventive practices were found to be utilized at lower frequencies compared to risk increasing practices. Awareness of bacterial zoonoses is particularly low within the region. Conclusions: Based on the results of this review, it was determined that improving farmer awareness of bacterial zoonotic diseases may favor several of the presented leverage points within the South Asian smallholder dairy system. Relying on formal school education to improve this awareness may not solve this problem, instead, more focus on accessible and affordable zoonoses education and farming programs is required.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135922516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.4103/1995-7645.388389
Rui He, Siqi Zhong, Jinghua Fan
Rationale: Aeromonas hydrophila , a bacterium commonly found in a variety of soils, aquatic habitats, and other natural environments, is known for causing infections and hemorrhagic diseases in both aquatic and terrestrial animals. Patients with leukemia, when infected by Aeromonas hydrophila following chemotherapy, face an increased risk of developing necrotizing fasciitis. Patient concerns: A 48-year-old male with a history of acute myeloid leukemia presented with swelling and pain in his right hand after being stabbed by a grass carp two days ago. The injury occurred on the fifth day after his last chemotherapy session when he was accidentally punctured in the right thumb and ring finger by a carp while fishing. Two days following the injury, the skin isurrounding the wound turned black immediately, while the rest of his hand was reddened, swollen, and bleeding. Diagnosis: Aeromonas hydrophila infection in the soft tissue of the right hand. Interventions: Intravenous antibiotics and local debridement. Outcomes: The patient experienced an alleviation of systemic poisoning symptoms, effective control of the local wound infection. Lessons: It is important for physicians to appreciate the potential for highly unusual and life-threatening infections in patients with acute myeloid leukemia. Early diagnosis and prompt treatment can prevent the development of necrotizing fasciitis and save patients' lives.
{"title":"Aeromonas hydrophila infection in acute myeloid leukemia: A case report","authors":"Rui He, Siqi Zhong, Jinghua Fan","doi":"10.4103/1995-7645.388389","DOIUrl":"https://doi.org/10.4103/1995-7645.388389","url":null,"abstract":"Rationale: Aeromonas hydrophila , a bacterium commonly found in a variety of soils, aquatic habitats, and other natural environments, is known for causing infections and hemorrhagic diseases in both aquatic and terrestrial animals. Patients with leukemia, when infected by Aeromonas hydrophila following chemotherapy, face an increased risk of developing necrotizing fasciitis. Patient concerns: A 48-year-old male with a history of acute myeloid leukemia presented with swelling and pain in his right hand after being stabbed by a grass carp two days ago. The injury occurred on the fifth day after his last chemotherapy session when he was accidentally punctured in the right thumb and ring finger by a carp while fishing. Two days following the injury, the skin isurrounding the wound turned black immediately, while the rest of his hand was reddened, swollen, and bleeding. Diagnosis: Aeromonas hydrophila infection in the soft tissue of the right hand. Interventions: Intravenous antibiotics and local debridement. Outcomes: The patient experienced an alleviation of systemic poisoning symptoms, effective control of the local wound infection. Lessons: It is important for physicians to appreciate the potential for highly unusual and life-threatening infections in patients with acute myeloid leukemia. Early diagnosis and prompt treatment can prevent the development of necrotizing fasciitis and save patients' lives.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.4103/1995-7645.388384
Shrikant Nema, Nitika Nitika, Anup R Anvikar, Praveen K Bharti
{"title":"Malaria slide bank plays a crucial role in achieving and sustaining malaria elimination in India","authors":"Shrikant Nema, Nitika Nitika, Anup R Anvikar, Praveen K Bharti","doi":"10.4103/1995-7645.388384","DOIUrl":"https://doi.org/10.4103/1995-7645.388384","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To estimate the risk of chronic kidney disease in patients with leptospirosis. Methods: All reported (41 890) and later confirmed leptospirosis (1 990) cases from 2010-2020 were traced by universal sampling. 386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age, gender, area, and occupation matched healthy persons were included as controls. Variables including socio-demographic characteristics, medical history, and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate (eGFR) was analyzed with multiple linear regression. Results: The median of eGFR was 49.0 (27.0, 75.0) mL/min/1.73 m 2 in the cases and 96.0 (72.0, 121.0) mL/min/1.73 m 2 in the controls, showing significant differences ( P <0.001). Bivariate analysis showed that leptospirosis seropositivitiy, repeat leptospirosis infection, diabetes, male gender, working in field (sun exposure), COVID-19 infection and smoking had statistically significant association with reduced eGFR. Leptospirosis seropositivity had negative effects on eGFR. Multiple linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR (unstandardised p coefficients= −30.86, 95% CI −49.7 to −11.9, P <0.001). Conclusions: Chronic kidney disease is a complex disease with multiple risk factors involved. Exposure to leptospirosis is one of the essential factors in accelerating its progression.
{"title":"Risk estimation of chronic kidney disease in a leptospirosis endemic area: A case-control study from south Andaman Islands of India","authors":"Ambreen Fatema, Manjunatha Ramu, Paluru Vijayachari","doi":"10.4103/1995-7645.388385","DOIUrl":"https://doi.org/10.4103/1995-7645.388385","url":null,"abstract":"Objective: To estimate the risk of chronic kidney disease in patients with leptospirosis. Methods: All reported (41 890) and later confirmed leptospirosis (1 990) cases from 2010-2020 were traced by universal sampling. 386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age, gender, area, and occupation matched healthy persons were included as controls. Variables including socio-demographic characteristics, medical history, and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate (eGFR) was analyzed with multiple linear regression. Results: The median of eGFR was 49.0 (27.0, 75.0) mL/min/1.73 m 2 in the cases and 96.0 (72.0, 121.0) mL/min/1.73 m 2 in the controls, showing significant differences ( P <0.001). Bivariate analysis showed that leptospirosis seropositivitiy, repeat leptospirosis infection, diabetes, male gender, working in field (sun exposure), COVID-19 infection and smoking had statistically significant association with reduced eGFR. Leptospirosis seropositivity had negative effects on eGFR. Multiple linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR (unstandardised p coefficients= −30.86, 95% CI −49.7 to −11.9, P <0.001). Conclusions: Chronic kidney disease is a complex disease with multiple risk factors involved. Exposure to leptospirosis is one of the essential factors in accelerating its progression.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/1995-7645.386257
Zainul Khaqiqi Nantabah, Rofingatul Mubasyiroh, Antonius Yudi Kristanto, Lely Indrawati, Astridya Paramita, Dwi Hapsari Tjandrarini, Agung Dwi Laksono
Objective: To investigate individual characteristics related to satisfaction with the quality of First Health Facility Services (FHFS) in Indonesia. Methods: This cross-sectional study analyzes national representation data. Meanwhile, the study involved 9846 representative respondents in 2019. Respondent's satisfaction with FHFS based on the five dimensions of service quality (SERVQUAL) is a dependent variable. Independent variables consist of sex, marital status, age, education, employment, insurance ownership, and economics. The study used multivariate logistic regression to explain the relationship between individual characteristics and FSHS quality. Results: 77.3% Respondents were satisfied with FHFS, with the highest order of satisfaction dimensions being assurance (59.4%), empathy (57.3%), reliability (53.6%), responsiveness (52.7%), and then tangibility (49.1%). Multivariate logistic analysis showed that divorce was 1.48 more likely than never-married to be satisfied (95% CI 1.17-1.87). Employees were 0.77 less likely than the unemployed to get satisfied (95% CI 0.70-0.86). Respondents with higher education was 0.82 less likely than those with primary education to be satisfied (95% CI 0.67-0.99). Meanwhile, respondents who had government-run insurance were 1.61 more likely than uninsured to be satisfied (95% CI 1.42-1.80). Moreover, the rich were 0.82 less likely than the poor to get satisfied (95% CI 0.73-0.92). Conclusions: Community satisfaction with FHFS is generally high, though some areas could be improved. Demographic factors are still strongly related to satisfaction ratings. The government can assess the quality of services in accordance with standards and disseminate information about service standards for primary facilities to all levels of society, ensuring that service satisfaction is rated as good by all groups.
目的:调查印度尼西亚第一卫生设施服务(FHFS)质量满意度的个体特征。方法:本横断面研究分析了国家代表性数据。同时，该研究在2019年涉及9846名代表性受访者。基于服务质量五个维度(SERVQUAL)的被调查者对FHFS的满意度是一个因变量。自变量包括性别、婚姻状况、年龄、教育程度、就业、保险所有权和经济状况。本研究采用多元逻辑回归分析个体特征与FSHS质量之间的关系。结果:77.3%的被调查者对家庭健康服务的满意度最高，满意度维度依次为保证(59.4%)、共情(57.3%)、信度(53.6%)、反应性(52.7%)和可触性(49.1%)。多变量逻辑分析显示，离婚的满意度比未婚的高1.48 (95% CI 1.17-1.87)。雇员的满意度比失业者低0.77 (95% CI 0.70-0.86)。接受过高等教育的受访者满意度比接受过初等教育的受访者低0.82 (95% CI 0.67-0.99)。与此同时，有政府经营保险的受访者比没有保险的人满意的可能性高1.61(95%可信区间1.42-1.80)。此外，富人的满意度比穷人低0.82 (95% CI 0.73-0.92)。结论:社区对FHFS的满意度总体较高，但仍存在一些有待改进的地方。人口因素仍然与满意度评级密切相关。政府可以按照标准对服务质量进行评估，并向社会各阶层宣传基层设施的服务标准，确保各群体的服务满意度都是良好的。
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