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Ferritin and mortality in hemodialysis patients with COVID-19: A systematic review and meta-analysis 铁蛋白与 COVID-19 血液透析患者的死亡率:系统回顾和荟萃分析
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4103/apjtm.apjtm_624_23
Ni Wayan Anantika Riani, I. Widiana, Y. Kandarini
To investigate the difference in serum ferritin levels between deceased and surviving regular hemodialysis patients with COVID-19. We conducted a systematic search across four databases following the PRISMA statement guidelines. Studies reporting ferritin levels and mortality of regular hemodialysis patients with COVID-19 were included. Employing the random-effects model, we performed a meta-analysis to determine the mean difference in serum ferritin levels between the studied groups, along with their corresponding 95% confidence intervals. The meta-analysis was carried out using Review Manager 5.4 and Stata 16. A total of 1 013 patients from seven studies were included in this study. Our meta-analysis showed higher mean serum ferritin in the deceased compared to surviving regular hemodialysis patients with COVID-19, with a mean difference of 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]. Our study found a higher mean of serum ferritin levels in the deceased compared to surviving regular hemodialysis patients with COVID-19.
研究 COVID-19 已故和存活的定期血液透析患者血清铁蛋白水平的差异。 我们按照 PRISMA 声明指南在四个数据库中进行了系统检索。纳入了报告 COVID-19 定期血液透析患者铁蛋白水平和死亡率的研究。我们采用随机效应模型进行了荟萃分析,以确定研究组间血清铁蛋白水平的平均差异及其相应的 95% 置信区间。荟萃分析使用 Review Manager 5.4 和 Stata 16 进行。 本研究共纳入了 7 项研究中的 1 013 名患者。我们的荟萃分析表明,与存活的常规血液透析患者相比,COVID-19 死亡患者的平均血清铁蛋白更高,平均差异为 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]。 我们的研究发现,与COVID-19存活的普通血液透析患者相比,已故患者的血清铁蛋白平均水平更高。
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引用次数: 0
Revisiting HPV infection pattern among urban Indonesian women in general population and its implication on health burden: A cross-sectional analysis from Indonesian Noncommunicable Disease Research 2016 重新审视印尼城市普通人群中女性的HPV感染模式及其对健康负担的影响:2016年印度尼西亚非传染性疾病研究》的横断面分析
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.391778
Frans Dany, K. Adam, Sarwo Handayani, Holy Arif Wibowo, Rita Marleta Dewi, N. Kipuw, Khariri, Widoretno
To identify circulating HPV types among urban Indonesian women and their specific co-infection patterns in bid to curb HPV infection in the general population and minimize its complications. Urban Indonesian women from general population were selected as sample framework. Sample size and distribution across regions were determined by the Indonesian Bureau of Statistics (Badan Pusat Statistik, BPS), which represented the national level. Up to 35 408 cervical swab specimens were collected from August to September 2016 in 34 Indonesian provinces, categorized into six regions based on the development criteria set by the Ministry of National Development Planning (Badan Perencanaan Pembangunan Nasional, BAPPENAS). From all 1874 samples identified as HPV-positive, hybrid capture was implemented to evaluate type-specific HPV. This study analyzed descriptive data to determine the core-cluster of HPV combination. Co-occurrence HPV network was assessed using ‘qgraph’ package version 1.6.3 and computed in R version 3.6.3. Two-HPV association was analyzed in logistic regression using bias-reduction generalized linear model (brglm2) package version 0.5.1 adjusted by age and six main Indonesian regions. The logistic regression analysis demonstrated that HPV type 52 had rare relationship despite its common co-occurrence, cementing its role in single HPV infection. HPV type 16 and 18 tended to form infection cluster and were strongly associated with other types. HPV type 52 was the most frequent HPV type among urban Indonesian women and accounted for most single infection cases. Concurrently, HPV 16 and HPV 18 accounted for most multiple infection cases and had strong tendency to attract other types, which may add further complications. However, due to lack of cytology and histological examination and information for other potential determinants, further in-depth studies are necessary to confirm whether these infection patterns truly connect to certain clinical outcomes.
确定印尼城市妇女中流行的人乳头瘤病毒类型及其特定的合并感染模式,以遏制普通人群中的人乳头瘤病毒感染并将其并发症降至最低。 从普通人群中选取印尼城市妇女作为样本框架。印度尼西亚统计局(Badan Pusat Statistik,BPS)代表国家层面确定了样本量和各地区的分布情况。根据国家发展规划部(Badan Perencanaan Pembangunan Nasional, BAPPENAS)制定的发展标准,印尼将34个省份划分为6个地区,并于2016年8月至9月期间收集了多达35 408份宫颈拭子标本。在所有 1874 份被鉴定为 HPV 阳性的样本中,采用混合捕获法对特定类型的 HPV 进行评估。本研究分析了描述性数据,以确定 HPV 组合的核心群组。使用 1.6.3 版 "qgraph "软件包评估了共现 HPV 网络,并在 3.6.3 版 R 中进行了计算。使用 0.5.1 版偏差还原广义线性模型 (brglm2) 软件包对两种 HPV 的关联进行了逻辑回归分析,并根据年龄和印度尼西亚的六个主要地区进行了调整。 逻辑回归分析表明,HPV 52 型尽管常见于共同感染,但其关系罕见,这巩固了其在单一 HPV 感染中的作用。HPV16型和18型倾向于形成感染群,并与其他类型密切相关。 在印尼城市妇女中,HPV 52 型是最常见的 HPV 类型,在单一感染病例中占多数。同时,HPV 16 型和 HPV 18 型在多重感染病例中占多数,并有吸引其他类型的强烈倾向,这可能会增加并发症。然而,由于缺乏细胞学和组织学检查以及其他潜在决定因素的信息,有必要进行进一步的深入研究,以确认这些感染模式是否真的与某些临床结果有关。
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引用次数: 0
The alarming surge of HIV/AIDS in Khyber Pakhtunkhwa, Pakistan demands urgent attention 巴基斯坦开伯尔-普赫图赫瓦省艾滋病毒/艾滋病急剧上升,令人震惊,亟需关注
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.391783
Abdullah, Riaz Muhammad, Aiman Waheed, Sher Ali, Muddasir Khan
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引用次数: 0
Resveratrol as an epigenetic therapy for flavivirus infection: A narrative review 白藜芦醇作为黄病毒感染的表观遗传疗法:叙述性综述
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.391776
Kim-Ling Chin, Kim-Kee Tan, S. Bakar, N. Zainal
Flaviviruses are a group of positive-stranded RNA viruses that cause a broad spectrum of severe illnesses in humans worldwide. Clinical manifestations of flavivirus infections range from mild febrile illness to hemorrhage, shock, and neurological manifestations. Flavivirus infections cause a substantial global health impact, with an estimated more than 400 million cases of infections annually. Hence, an understanding of flavivirus-host interaction is urgently needed for new antiviral therapeutic strategies. In recent years, many aspects concerning epigenetic therapy for viral infections have been addressed, including methylation of the genome, acetylation/deacetylation of histone complex and microRNA regulation. In this context, we surveyed and reviewed the literature and summarized the epigenetic effects of resveratrol, a natural polyphenol with potential anti-viral properties, on flavivirus infections.
黄病毒是一组正链 RNA 病毒,可在全球范围内引起多种严重疾病。黄病毒感染的临床表现从轻微发热到出血、休克和神经系统表现不等。黄病毒感染对全球健康造成重大影响,估计每年感染病例超过 4 亿例。因此,迫切需要了解黄病毒与宿主的相互作用,以制定新的抗病毒治疗策略。近年来,有关病毒感染的表观遗传学疗法的许多方面都得到了研究,包括基因组的甲基化、组蛋白复合物的乙酰化/去乙酰化和微RNA调控。在此背景下,我们调查并回顾了相关文献,总结了白藜芦醇(一种具有潜在抗病毒特性的天然多酚)对黄病毒感染的表观遗传学影响。
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引用次数: 0
Developing an evaluation model to support evidence-based decision-making on provincial vaccination program of Zhejiang province 建立支持浙江省省级疫苗接种项目循证决策的评估模型
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.390168
Fuxing Chen, Linlin Ding, H. Liang, Ying Wang, Yu Hu
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引用次数: 0
Evaluation of parasitemia by qPCR in patients with chronic Chagas disease treated with benznidazole 通过 qPCR 评估接受苯并咪唑治疗的慢性南美锥虫病患者的寄生虫血症
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.391781
T. B. S. Pavan, E. A. Almeida, Rodrigo Gonçalves de Lima, J. Wanderley, L. Martins, Sandra Cecília Botelho Costa, G. Marcon
To evaluate parasitemia by qPCR in patients undergoing etiological treatment and followed in a Brazilian reference center. Parasite load was quantified by qPCR in 32 participants with chronic Chagas disease who were treated with benznidazole. Serological analyses were performed before and after the treatment and parasite loads were compared prior and 12/18 months post the treatment. Thirty-two participants were recruited and treated with benznidazole, and 20 were followed-up. Adverse events (AE) were observed in 22 out of 29 participants that had safety data (76%), and dermatological alterations were the most frequently observed AE. Of the 20 participants analyzed, 13 and 7 completed 12 and 18 months follow-up after the treatment, respectively. 12 Months after the final treatment, Trypanosoma cruzi was detectable in 3 patients by qPCR; 18 months after the final treatment, Trypanosoma cruzi was detectable per qPCR in 4 of the 7 participants. Thus, between 12 and 18 months, 7 participants of the 20 initial follow-up cases showed positive qPCR, indicating treatment failures. qPCR can be used as an alternative method for evaluating the effectiveness of the etiological treatment of CD, and can be applied to analyze early therapeutic failures. The study showed that benznidazole therapy had limited effectiveness in treating chronic CD patients, thus emphasizing the importance of conducting continued research for developing more effective therapies and diagnosis for CD.
通过 qPCR 对接受病原学治疗并在巴西参考中心接受随访的患者的寄生虫血症进行评估。 通过 qPCR 对 32 名接受苯并咪唑治疗的慢性南美锥虫病患者的寄生虫量进行量化。在治疗前后进行了血清学分析,并比较了治疗前和治疗后 12/18 个月的寄生虫数量。 该研究招募了 32 名参与者,并对他们进行了苯并咪唑治疗,其中 20 人接受了随访。在有安全性数据的 29 名参与者中,有 22 人(76%)出现了不良反应(AE),皮肤病改变是最常见的不良反应。在分析的 20 名参与者中,分别有 13 人和 7 人完成了治疗后 12 个月和 18 个月的随访。最终治疗 12 个月后,3 名患者通过 qPCR 检测到了克鲁斯潘诺虫;最终治疗 18 个月后,7 名参与者中有 4 人通过 qPCR 检测到了克鲁斯潘诺虫。因此,在 12 至 18 个月期间,20 例初次随访病例中有 7 例出现了 qPCR 阳性,表明治疗失败。qPCR 可作为评价 CD 病因治疗效果的替代方法,并可用于分析早期治疗失败。该研究表明,苯并咪唑疗法对慢性 CD 患者的治疗效果有限,因此强调了继续研究开发更有效的 CD 治疗和诊断方法的重要性。
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引用次数: 0
Vaccine development for leptospirosis: A systematic review 钩端螺旋体病疫苗开发:系统回顾
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.4103/1995-7645.391775
Yocyny Surendran, Mahalingam Nandikha, Syafinaz Amin-Nordin, Sandeep Kumar Dhanda, Mohamad Ridhuan Mohd Ali, Narcisse M S Joseph
To assess the efficacy of various types of vaccines developed for leptospirosis. A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria are all Leptospira species regardless of any cluster (pathogenic, intermediate and non-pathogenic). This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine candidates. The studies on the effectiveness of outer membrane protein as vaccine candidates were also included. The articles obtained in the databases were imported into the WPS spreadsheet, and duplicate documents were removed manually. A total of 24 studies were included in the review, which evaluated various types of leptospirosis vaccines. Multiple vaccines were developed and tested; however, the heterogeneity of Leptospira species pose a challenge. As an effective approach, an epitope based vaccine shows quite a promising result. However, sufficient validation, testing and clinical trials are required. Developing an effective vaccine for leptospirosis remains a global health priority. While significant progress has been made in recent years, there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations.
评估针对钩端螺旋体病开发的各类疫苗的功效。 我们在三个数据库中进行了全面搜索:PubMed、Scopus 和 Cochrane Library。两位作者(YS 和 MN)通过人工筛选的方式选出了文章。研究的资格标准是所有钩端螺旋体物种,不分群组(致病性、中间型和非致病性)。本研究记录了结果为阳性和阴性的文章,并对作为候选疫苗的各种膜蛋白进行了比较。此外,还包括有关外膜蛋白作为候选疫苗的有效性的研究。从数据库中获得的文章被导入到 WPS 电子表格中,重复文件被手动删除。 本综述共纳入 24 项研究,对各种类型的钩端螺旋体疫苗进行了评估。研究人员开发并测试了多种疫苗;然而,钩端螺旋体物种的异质性带来了挑战。作为一种有效的方法,基于表位的疫苗显示出良好的效果。不过,还需要进行充分的验证、测试和临床试验。 开发有效的钩端螺旋体病疫苗仍是全球健康的当务之急。虽然近年来已取得了重大进展,但仍需进一步研究,以优化疫苗开发,确保疫苗对高危人群的可及性和有效性。
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引用次数: 0
Glycolysis and acute lung injury: A review 糖酵解与急性肺损伤:综述
4区 医学 Q2 Medicine Pub Date : 2023-11-08 DOI: 10.4103/1995-7645.388388
Yang Yi, Jun Chen, Nan Li, Yue Huang, Jichao Peng, Xiaoran Liu
Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.
急性肺损伤以肺或全身损伤引起的弥漫性肺水肿和持续性低氧血症为特征。这些病理变化被认为与肺泡上皮和血管内皮的损伤、炎症细胞的募集和炎症因子风暴有关。近年来,肺实质细胞和免疫细胞的代谢重编程,特别是糖酵解的改变,已被发现发生在急性肺损伤中。抑制糖酵解可减轻急性肺损伤的严重程度。因此,本文就急性肺损伤与糖酵解的相互关系及其相互作用机制进行综述,以期为急性肺损伤的治疗带来希望。
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引用次数: 0
Mycobacterium tuberculosis infection among children under fifteen years of age: A population-based study in Indonesia 十五岁以下儿童的结核分枝杆菌感染情况:印度尼西亚的一项人口研究
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-11-01 DOI: 10.4103/1995-7645.388387
Made Agus Nurjana, A. Laksono, I Kadek Wartana, Vidyanto, Gunawan, A. Nursafingi, Samarang, H. Anastasia, Kristina Tobing, Anis Nurwidayati, Octaviani
Objective: To assess the prevalence of Mycobacterium (M.) tuberculosis infection and its associated risks in children under fifteen years of age. Methods: Based on secondary data from the 2018 Indonesian Basic Health Survey (RISKESDAS 2018), this cross-sectional study employed M. tuberculosis infection in children as a dependent variable and age level, sex, region, location, family case positive, and smoking as independent variables. Geospatial analysis was applied to show the prevalence of M. tuberculosis infection and multivariate regression was performed to analyze the risk factors of getting the infection among children under 15 years of age. Results: Prevalence ranges of M. tuberculosis infection among children aged 0-14 years, babies (age <12 months), toddlers (age 12-59 months), and children aged between 5 and 14 years were 0.03% to 0.57%, 0% to 0.64%, 0% to 0.78%, and 0.01% to 0.53%, respectively in Indonesia. A high prevalence of M. tuberculosis infection among children under 15 years of age was found in Papua and other provinces, such as Kalimantan and Java. Contacting with tuberculosis family members was positively associated with M. tuberculosis infection in children as shown by multivariate logistic regression (OR 8.94; 95% CI 5.4-14.6, P<0.05). Conclusions: Contacting with family member who has tuberculosis is related with M. tuberculosis infection among children in Indonesia. Therefore, screening the household for contact with tuberculosis patients is a preventive treatment for children.
目的评估 15 岁以下儿童结核分枝杆菌感染率及其相关风险。方法:基于 2018 年印度尼西亚基本健康调查(RISAS)的二手数据:基于 2018 年印度尼西亚基本健康调查(RISKESDAS 2018)的二手数据,本横断面研究采用儿童结核分枝杆菌感染作为因变量,年龄水平、性别、地区、地点、家庭病例阳性和吸烟作为自变量。应用地理空间分析显示结核杆菌感染率,并进行多元回归分析 15 岁以下儿童感染结核杆菌的风险因素。结果印度尼西亚0-14岁儿童、婴儿(年龄小于12个月)、幼儿(年龄12-59个月)和5-14岁儿童的结核杆菌感染率范围分别为0.03%-0.57%、0%-0.64%、0%-0.78%和0.01%-0.53%。巴布亚以及加里曼丹和爪哇等其他省份发现,15 岁以下儿童的结核杆菌感染率较高。多变量逻辑回归(OR 8.94; 95% CI 5.4-14.6,P<0.05)显示,与结核病家庭成员接触与儿童感染结核杆菌呈正相关。结论与患有结核病的家庭成员接触与印度尼西亚儿童感染结核杆菌有关。因此,筛查与肺结核患者接触过的家庭是对儿童的一种预防性治疗。
{"title":"Mycobacterium tuberculosis infection among children under fifteen years of age: A population-based study in Indonesia","authors":"Made Agus Nurjana, A. Laksono, I Kadek Wartana, Vidyanto, Gunawan, A. Nursafingi, Samarang, H. Anastasia, Kristina Tobing, Anis Nurwidayati, Octaviani","doi":"10.4103/1995-7645.388387","DOIUrl":"https://doi.org/10.4103/1995-7645.388387","url":null,"abstract":"Objective: To assess the prevalence of Mycobacterium (M.) tuberculosis infection and its associated risks in children under fifteen years of age. Methods: Based on secondary data from the 2018 Indonesian Basic Health Survey (RISKESDAS 2018), this cross-sectional study employed M. tuberculosis infection in children as a dependent variable and age level, sex, region, location, family case positive, and smoking as independent variables. Geospatial analysis was applied to show the prevalence of M. tuberculosis infection and multivariate regression was performed to analyze the risk factors of getting the infection among children under 15 years of age. Results: Prevalence ranges of M. tuberculosis infection among children aged 0-14 years, babies (age <12 months), toddlers (age 12-59 months), and children aged between 5 and 14 years were 0.03% to 0.57%, 0% to 0.64%, 0% to 0.78%, and 0.01% to 0.53%, respectively in Indonesia. A high prevalence of M. tuberculosis infection among children under 15 years of age was found in Papua and other provinces, such as Kalimantan and Java. Contacting with tuberculosis family members was positively associated with M. tuberculosis infection in children as shown by multivariate logistic regression (OR 8.94; 95% CI 5.4-14.6, P<0.05). Conclusions: Contacting with family member who has tuberculosis is related with M. tuberculosis infection among children in Indonesia. Therefore, screening the household for contact with tuberculosis patients is a preventive treatment for children.","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elimination of lymphatic filariasis-Challenging but not impossible 消除淋巴丝虫病--具有挑战性但并非不可能
IF 3.1 4区 医学 Q2 Medicine Pub Date : 2023-11-01 DOI: 10.4103/1995-7645.390167
Lakshmi Krishnasamy
{"title":"Elimination of lymphatic filariasis-Challenging but not impossible","authors":"Lakshmi Krishnasamy","doi":"10.4103/1995-7645.390167","DOIUrl":"https://doi.org/10.4103/1995-7645.390167","url":null,"abstract":"","PeriodicalId":8559,"journal":{"name":"Asian Pacific journal of tropical medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139302990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Asian Pacific journal of tropical medicine
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