Pub Date : 2022-01-01DOI: 10.4103/2305-0500.335856
V. Titapant, Saifon Chawanpaiboon, S. Anuwutnavin, Attapol Kanjanapongporn, J. Pooliam, Pimolphan Tangwiwat
Objective: To identify healthcare managers’ perspectives on the barriers to implementing cervical length screening to prevent preterm births. Methods: In Phase I, 10 healthcare managers were interviewed. Phase II comprised questionnaire development and data validation. In Phase III, the questionnaire was administered to 40 participants, and responses were analyzed. Results: Their average related work experience was (21.0±7.2) years; 39 (97.5%) respondents also had healthcare management responsibilities at their respective hospitals. Most hospitals were reported to have enough obstetricians (31 cases, 77.5%) and to be able to accurately perform cervical length measurements (22 cases, 55.0%). However, no funding was allocated to universal cervical length screening (39 cases, 97.5%). Most respondents believed that implementing universal screening, as per Ministry of Public Health policies, would prevent preterm births (28 cases, 70.0%). Moreover, they suggested that hospital fees for cervical length measurements should be waived (34 cases, 85.0%). Three main perceived barriers to universal screening at tertiary hospitals were identified. They were heavy obstetrician workloads (20 cases, 50.0%); inadequate numbers of medical personnel (24 cases, 60.0%); not believing that the screening test could prevent preterm birth (8 cases, 20%) and lack of free drug support for preterm birth prevention in high-risk cases (29 cases, 72.5%). Conclusions: The main obstacles to universal cervical length screening are heavy staff workloads and inadequate government funding for ultrasound scanning and hormone therapy. The healthcare managers do not believe that the universal cervical length screening can help to reduce preterm birth.
{"title":"An implementation study of barriers to universal cervical length screening for preterm birth prevention at tertiary hospitals in Thailand: Healthcare managers’ perspectives","authors":"V. Titapant, Saifon Chawanpaiboon, S. Anuwutnavin, Attapol Kanjanapongporn, J. Pooliam, Pimolphan Tangwiwat","doi":"10.4103/2305-0500.335856","DOIUrl":"https://doi.org/10.4103/2305-0500.335856","url":null,"abstract":"Objective: To identify healthcare managers’ perspectives on the barriers to implementing cervical length screening to prevent preterm births. Methods: In Phase I, 10 healthcare managers were interviewed. Phase II comprised questionnaire development and data validation. In Phase III, the questionnaire was administered to 40 participants, and responses were analyzed. Results: Their average related work experience was (21.0±7.2) years; 39 (97.5%) respondents also had healthcare management responsibilities at their respective hospitals. Most hospitals were reported to have enough obstetricians (31 cases, 77.5%) and to be able to accurately perform cervical length measurements (22 cases, 55.0%). However, no funding was allocated to universal cervical length screening (39 cases, 97.5%). Most respondents believed that implementing universal screening, as per Ministry of Public Health policies, would prevent preterm births (28 cases, 70.0%). Moreover, they suggested that hospital fees for cervical length measurements should be waived (34 cases, 85.0%). Three main perceived barriers to universal screening at tertiary hospitals were identified. They were heavy obstetrician workloads (20 cases, 50.0%); inadequate numbers of medical personnel (24 cases, 60.0%); not believing that the screening test could prevent preterm birth (8 cases, 20%) and lack of free drug support for preterm birth prevention in high-risk cases (29 cases, 72.5%). Conclusions: The main obstacles to universal cervical length screening are heavy staff workloads and inadequate government funding for ultrasound scanning and hormone therapy. The healthcare managers do not believe that the universal cervical length screening can help to reduce preterm birth.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"1 - 11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41794038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4103/2305-0500.335858
Kuntima Kantawee, W. Somboonporn
Objective: To study the prevalence and associated factors of recurrent ovarian endometrioma after ovarian cystectomy. Methods: This retrospective study analyzed 303 patients who underwent cystectomy for ovarian endometrioma and had at least a 2-year follow-up at Srinagarind Hospital from January 2013 to December 2018. The patients were divided into the recurrent and nonrecurrent groups according to the findings from postoperative transvaginal ultrasonography 6 months after undergoing surgery. Nineteen factors were collected for risk evaluation. The prevalence of recurrent ovarian endometrioma and its 95% confident interval (CI) were calculated. Univariate and multivariable logistic regression analyses were performed to determine the association between factors and recurrence. Results: Recurrent ovarian endometrioma occurred in 33% (95% CI 27.7%-38.3%) patients. The median duration of follow-up was 36 months. during the median follow-up period of 36 months. Preoperative history of parity, preoperative infertility history, endometriosis surgery, moderate to severe dysmenorrhea, dyspareunia, intraoperative stage 4 according to revised American Society for Reproductive Medicine classification, presence of adenomyosis, and postoperative pain relief were associated factors based on univariate analysis. In contrast, infertility [odds ratio (OR) 2.22, 95% CI 1.14-4.33], moderate to severe dysmenorrhea (OR 2.13, 95% CI 1.09-4.15), and postoperative pelvic pain relief (OR 0.22, 95% CI 0.12-0.42) were independently associated factors based on multivariable logistic regression analysis. Conclusions: In our setting, preoperative infertility history and moderate to severe dysmenorrhea were associated with a higher recurrent ovarian endometrioma risk. In contrast, postoperative pain relief was significantly associated with lower recurrence risk.
{"title":"Recurrent ovarian endometrioma after conservative surgery: A retrospective study","authors":"Kuntima Kantawee, W. Somboonporn","doi":"10.4103/2305-0500.335858","DOIUrl":"https://doi.org/10.4103/2305-0500.335858","url":null,"abstract":"Objective: To study the prevalence and associated factors of recurrent ovarian endometrioma after ovarian cystectomy. Methods: This retrospective study analyzed 303 patients who underwent cystectomy for ovarian endometrioma and had at least a 2-year follow-up at Srinagarind Hospital from January 2013 to December 2018. The patients were divided into the recurrent and nonrecurrent groups according to the findings from postoperative transvaginal ultrasonography 6 months after undergoing surgery. Nineteen factors were collected for risk evaluation. The prevalence of recurrent ovarian endometrioma and its 95% confident interval (CI) were calculated. Univariate and multivariable logistic regression analyses were performed to determine the association between factors and recurrence. Results: Recurrent ovarian endometrioma occurred in 33% (95% CI 27.7%-38.3%) patients. The median duration of follow-up was 36 months. during the median follow-up period of 36 months. Preoperative history of parity, preoperative infertility history, endometriosis surgery, moderate to severe dysmenorrhea, dyspareunia, intraoperative stage 4 according to revised American Society for Reproductive Medicine classification, presence of adenomyosis, and postoperative pain relief were associated factors based on univariate analysis. In contrast, infertility [odds ratio (OR) 2.22, 95% CI 1.14-4.33], moderate to severe dysmenorrhea (OR 2.13, 95% CI 1.09-4.15), and postoperative pelvic pain relief (OR 0.22, 95% CI 0.12-0.42) were independently associated factors based on multivariable logistic regression analysis. Conclusions: In our setting, preoperative infertility history and moderate to severe dysmenorrhea were associated with a higher recurrent ovarian endometrioma risk. In contrast, postoperative pain relief was significantly associated with lower recurrence risk.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"20 - 26"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41938536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331263
Suha Baloushah, S. Barjasteh, A. Elsous, A. Aldirawi, Soha Abu Eid, Atef Masad
Objective: To investigate the quality of life of infertile couples who seek in vitro fertilizations (IVFs) by gender in the Gaza Strip, Palestine. Methods: A cross-sectional study was conducted, from February 2019 to November 2019, among 383 infertile couples selected through convenient sampling. A valid and reliable Arabic version of the fertility quality of life questionnaire (FertiQoL) was used in data collection. One way analysis of variance and independent t-test were applied to compare between males and females. Results: The mean age of males and females was (34.54±8.54) years and (29.28±6.71) years, respectively. More than half of them had university degree (64% and 60%, respectively). The mean duration of infertility was (5.66±3.54) years. The mean males’ scores of FertiQoL and its subscales (emotion, mind/body, social, core, tolerability, and treatment) were significantly higher than females’ scores (P<0.05). Conclusions: Males have higher scores of FertiQoL and its subscales than females. The mean score of FertiQoL increases with better education, but decreases with increase of age, duration of marriage, duration of infertility and number of IVF attempts. Routine psychological assessment and counseling are necessary for infertile women taking into considerations factors affecting their quality of life.
{"title":"Quality of life of infertile couples in the Gaza Strip, Palestine","authors":"Suha Baloushah, S. Barjasteh, A. Elsous, A. Aldirawi, Soha Abu Eid, Atef Masad","doi":"10.4103/2305-0500.331263","DOIUrl":"https://doi.org/10.4103/2305-0500.331263","url":null,"abstract":"Objective: To investigate the quality of life of infertile couples who seek in vitro fertilizations (IVFs) by gender in the Gaza Strip, Palestine. Methods: A cross-sectional study was conducted, from February 2019 to November 2019, among 383 infertile couples selected through convenient sampling. A valid and reliable Arabic version of the fertility quality of life questionnaire (FertiQoL) was used in data collection. One way analysis of variance and independent t-test were applied to compare between males and females. Results: The mean age of males and females was (34.54±8.54) years and (29.28±6.71) years, respectively. More than half of them had university degree (64% and 60%, respectively). The mean duration of infertility was (5.66±3.54) years. The mean males’ scores of FertiQoL and its subscales (emotion, mind/body, social, core, tolerability, and treatment) were significantly higher than females’ scores (P<0.05). Conclusions: Males have higher scores of FertiQoL and its subscales than females. The mean score of FertiQoL increases with better education, but decreases with increase of age, duration of marriage, duration of infertility and number of IVF attempts. Routine psychological assessment and counseling are necessary for infertile women taking into considerations factors affecting their quality of life.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"262 - 268"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44657146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331264
M. Jalili, Samira Asadollahi, S. Seifati, H. Ashrafzadeh, N. Ghasemi
Objective: To investigate the frequency of -786T>C variant in endothelial nitric oxide synthase (eNOS) gene promoter in Iranian women with recurrent pregnancy loss. Methods: Blood samples were obtained from 100 unrelated women affected by recurrent pregnancy loss and 100 unaffected women as the controls. Genomic DNA was extracted and -786T>C polymorphism in eNOS gene promoter was investigated by PCR-RFLP method. Statistical analyses and Hardy-Weinberg equilibrium in the groups of patients and controls were performed by Chi-square test and SPSS standard software (Version 21). Results: The frequency of homozygous TT was 40% in cases and 46% in the control group; the frequency of CC was 7% in cases and 5% in the control group; frequency heterozygote TC was 53% in cases and 49% in the control group. Genotype frequencies between the two groups showed no significant differences (P>0.05). Conclusions: The -786T>C polymorphism is not more frequent in recurrent pregnancy loss in this population.
{"title":"Association between eNOS gene promoter polymorphism (-786T>C) and idiopathic recurrent pregnancy loss in Iranian women","authors":"M. Jalili, Samira Asadollahi, S. Seifati, H. Ashrafzadeh, N. Ghasemi","doi":"10.4103/2305-0500.331264","DOIUrl":"https://doi.org/10.4103/2305-0500.331264","url":null,"abstract":"Objective: To investigate the frequency of -786T>C variant in endothelial nitric oxide synthase (eNOS) gene promoter in Iranian women with recurrent pregnancy loss. Methods: Blood samples were obtained from 100 unrelated women affected by recurrent pregnancy loss and 100 unaffected women as the controls. Genomic DNA was extracted and -786T>C polymorphism in eNOS gene promoter was investigated by PCR-RFLP method. Statistical analyses and Hardy-Weinberg equilibrium in the groups of patients and controls were performed by Chi-square test and SPSS standard software (Version 21). Results: The frequency of homozygous TT was 40% in cases and 46% in the control group; the frequency of CC was 7% in cases and 5% in the control group; frequency heterozygote TC was 53% in cases and 49% in the control group. Genotype frequencies between the two groups showed no significant differences (P>0.05). Conclusions: The -786T>C polymorphism is not more frequent in recurrent pregnancy loss in this population.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"269 - 273"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46377279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331266
S. Athari, Keivan Lorian, Haniye Kashafroodi, Saadat Ghafarzadeh, R. Choopani
Objective: To evaluate the protective effects of honey compound syrup on sperm count and testis tissue in rats. Methods: Thirty rats were randomly assigned to five groups. The control group received 1 mL normal saline with dimethyl sulfoxide intraperitoneally; the busulfan group received busulfan 10 mg/kg body weight at the first and twenty-first days of the experiment via intraperitoneal injection; the last three groups received busulfan 10 mg/kg body weight to induce azoospermia, and then received 1.0, 1.5, or 2.0 mg/kg honey compound syrup, respectively, after induction of azoospermia. After administration, the testis and epididymis of all rats were removed. Then, reproductive organ weight and sperm parameters (sperm concentration, epididymal sperm reserve and daily sperm production) were measured. After hematoxylin-eosin staining, seminiferous tubule cells and diameters were assessed. Results: Busulfan damaged the testis tissue and impaired spermatogenesis. Administration of honey compound syrup in three doses improved testis tissue and spermatogenesis. The protective effects of honey compound syrup may relate to the antioxidant properties of honey and other compounds in this syrup. Conclusions: Administration of honey compound syrup could be an ameliorative agent for the side effects of chemotherapy drugs such as busulfan on the male reproductive system.
{"title":"Protective effects of honey compound syrup on busulfan-induced azoospermia in male rats","authors":"S. Athari, Keivan Lorian, Haniye Kashafroodi, Saadat Ghafarzadeh, R. Choopani","doi":"10.4103/2305-0500.331266","DOIUrl":"https://doi.org/10.4103/2305-0500.331266","url":null,"abstract":"Objective: To evaluate the protective effects of honey compound syrup on sperm count and testis tissue in rats. Methods: Thirty rats were randomly assigned to five groups. The control group received 1 mL normal saline with dimethyl sulfoxide intraperitoneally; the busulfan group received busulfan 10 mg/kg body weight at the first and twenty-first days of the experiment via intraperitoneal injection; the last three groups received busulfan 10 mg/kg body weight to induce azoospermia, and then received 1.0, 1.5, or 2.0 mg/kg honey compound syrup, respectively, after induction of azoospermia. After administration, the testis and epididymis of all rats were removed. Then, reproductive organ weight and sperm parameters (sperm concentration, epididymal sperm reserve and daily sperm production) were measured. After hematoxylin-eosin staining, seminiferous tubule cells and diameters were assessed. Results: Busulfan damaged the testis tissue and impaired spermatogenesis. Administration of honey compound syrup in three doses improved testis tissue and spermatogenesis. The protective effects of honey compound syrup may relate to the antioxidant properties of honey and other compounds in this syrup. Conclusions: Administration of honey compound syrup could be an ameliorative agent for the side effects of chemotherapy drugs such as busulfan on the male reproductive system.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"284 - 290"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48343792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331265
R. Dibyendu, Chatterjee Tiasa, Monalisha Das, Panda Pradip, Mukherjee Sandip
Objective: To investigate the effects of folic acid on testicular oxidative damage in sodium fluoride-induced male Wistar rats. Methods: A total of 24 male Wistar rats were divided into 4 groups: the control, sodium fluoride (fed with 100 mg/L sodium fluoride through drinking water orally for 21 days), folic acid (36 μg/kg body weight/day, orally), and sodium fluoride plus folic acid (received similar dose orally) groups. At the end of 21 days, epididymal sperm parameters, biochemical analysis of testicular tissue, and serum hormonal levels were performed along with histopathological studies. Results: Sodium fluoride intoxication resulted in marked reduction in gonado somatic index, serum luteinizing hormone, and testosterone level along with 3 β -hydroxysteroid dehydrogenase and 17 β -hydroxysteroid dehydrogenase activities. In addition, reduction in sperm density, as well as loss of sperm motility and sperm viability, were also observed. Besides, increased levels of testicular malondialdehyde, nitrite, interleukin-6 and tumor necrosis factor- α as well as decreased levels of superoxide dismutase and catalase activities and reduced glutathione content were found to be associated with this toxicity. Folic acid co-treatment, on the other hand, could prevent all the sodium fluoride-induced testicular pathophysiology and oxidative stress related parameters. Histological examinations of testicular sections from the experimental rats supported these results. Conclusions: Combining all, this study suggests that being an antioxidant, folic acid plays a beneficial role against fluoride-induced adverse effects on the male reproductive system.
{"title":"Folic acid protects against fluoride-induced oxidative stress and testicular damage in rats","authors":"R. Dibyendu, Chatterjee Tiasa, Monalisha Das, Panda Pradip, Mukherjee Sandip","doi":"10.4103/2305-0500.331265","DOIUrl":"https://doi.org/10.4103/2305-0500.331265","url":null,"abstract":"Objective: To investigate the effects of folic acid on testicular oxidative damage in sodium fluoride-induced male Wistar rats. Methods: A total of 24 male Wistar rats were divided into 4 groups: the control, sodium fluoride (fed with 100 mg/L sodium fluoride through drinking water orally for 21 days), folic acid (36 μg/kg body weight/day, orally), and sodium fluoride plus folic acid (received similar dose orally) groups. At the end of 21 days, epididymal sperm parameters, biochemical analysis of testicular tissue, and serum hormonal levels were performed along with histopathological studies. Results: Sodium fluoride intoxication resulted in marked reduction in gonado somatic index, serum luteinizing hormone, and testosterone level along with 3 β -hydroxysteroid dehydrogenase and 17 β -hydroxysteroid dehydrogenase activities. In addition, reduction in sperm density, as well as loss of sperm motility and sperm viability, were also observed. Besides, increased levels of testicular malondialdehyde, nitrite, interleukin-6 and tumor necrosis factor- α as well as decreased levels of superoxide dismutase and catalase activities and reduced glutathione content were found to be associated with this toxicity. Folic acid co-treatment, on the other hand, could prevent all the sodium fluoride-induced testicular pathophysiology and oxidative stress related parameters. Histological examinations of testicular sections from the experimental rats supported these results. Conclusions: Combining all, this study suggests that being an antioxidant, folic acid plays a beneficial role against fluoride-induced adverse effects on the male reproductive system.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"274 - 283"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44835701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331262
Monalisa Biswas, V. Belle, Nihaal Maripini, K. Prabhu
Pregnancy associated diseases/disorders are associated with significant maternal and neonatal morbidities and mortalities. Devising/validating cost effective and easily accessible predictive, diagnostic and risk stratification markers are critical to the management and improved outcome in these diseases. Inflammation forms the backbone of most of the routinely encountered maternal complications of pregnancy. Hematological markers can be considered as a direct reflection of the systemic inflammatory milieu. Recently, the neutrophil lymphocyte ratio has been explored for its potential to assess the severity of inflammation and thus the severity of the underlying disorder. The neutrophil-lymphocyte ratio has gained scientific attention as a potential prognostic/predictive marker of acute as well as chronic inflammatory diseases including gynecological and reproductive disorders. This present study reviews the mechanistic role of neutrophils and lymphocytes in fueling or propagating the inflammatory cascades in the three most common maternal complications of pregnancy and the evidence of clinical importance of the neutrophil to lymphocyte ratio in predicting, diagnosing, and prognosticating pregnancy-associated complications.
{"title":"Neutrophil-lymphocyte ratio in pregnancy-associated maternal complications: A review","authors":"Monalisa Biswas, V. Belle, Nihaal Maripini, K. Prabhu","doi":"10.4103/2305-0500.331262","DOIUrl":"https://doi.org/10.4103/2305-0500.331262","url":null,"abstract":"Pregnancy associated diseases/disorders are associated with significant maternal and neonatal morbidities and mortalities. Devising/validating cost effective and easily accessible predictive, diagnostic and risk stratification markers are critical to the management and improved outcome in these diseases. Inflammation forms the backbone of most of the routinely encountered maternal complications of pregnancy. Hematological markers can be considered as a direct reflection of the systemic inflammatory milieu. Recently, the neutrophil lymphocyte ratio has been explored for its potential to assess the severity of inflammation and thus the severity of the underlying disorder. The neutrophil-lymphocyte ratio has gained scientific attention as a potential prognostic/predictive marker of acute as well as chronic inflammatory diseases including gynecological and reproductive disorders. This present study reviews the mechanistic role of neutrophils and lymphocytes in fueling or propagating the inflammatory cascades in the three most common maternal complications of pregnancy and the evidence of clinical importance of the neutrophil to lymphocyte ratio in predicting, diagnosing, and prognosticating pregnancy-associated complications.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"252 - 261"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47985108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.4103/2305-0500.331261
Shonitha Sagadevan, Oorvashree Sri Hari, M. Sirajudeen, G. Ramalingam, R. Basutkar
Objective: To summarize whether the supplementation of L-arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal outcomes. Methods: Studies conducted from the past 17 years (1999 to 2016). were referred from database like Cochrane Central Registry of Controlled Trials (CENTRAL), Scopus, Google Scholar and PubMed. Out of 134 studies, 7 studies were included. L-arginine versus placebo was considered for quantitative analysis. Modified Cochrane data extraction form was used to collect the data. The risk of bias was assessed using Cochrane’s risk of bias assessment tool in RevMan 5.4 and the summary of findings was determined using GradePro software. Results: L-arginine showed a significant reduction of preeclampsia [odds ratio (OR) 0.38; 95% confidence interval (CI) 0.25, 0.58)]. There was a significant reduction in systolic blood pressure [mean difference (MD) -2.47; 95% CI -4.53, -0.42] and diastolic blood pressure (MD -0.97; 95% CI -3.83, 1.89). The effects of L-arginine on secondary outcomes like maternal gestational age, latency, neonatal weight, and appearance, pulse, grimace, activity, respiration (APGAR) score at 1st and 5th minute were not statistically significant. Conclusions: L-arginine supplementation is effective in lowering systolic and diastolic blood pressure of preeclamptic patients. However, it has no noticeable effects on maternal and neonatal outcomes.
目的:总结孕妇补充l -精氨酸是否有助于子痫前期的治疗及其对孕产妇和新生儿结局的影响。方法:研究时间为1999 - 2016年，共17年。均来源于Cochrane Central Registry of Controlled Trials (Central)、Scopus、谷歌Scholar和PubMed等数据库。在134项研究中，纳入了7项研究。将l -精氨酸与安慰剂进行定量分析。采用改进的Cochrane数据提取表收集数据。使用RevMan 5.4中的Cochrane偏倚风险评估工具评估偏倚风险，使用GradePro软件确定结果总结。结果:l -精氨酸显著降低子痫前期[优势比(OR) 0.38;95%置信区间(CI) 0.25, 0.58)]。收缩压显著降低[平均差值(MD) -2.47;95% CI -4.53， -0.42]和舒张压(MD -0.97;95% ci -3.83, 1.89)。l -精氨酸对产妇胎龄、潜伏期、新生儿体重、第1分钟和第5分钟外观、脉搏、面部表情、活动、呼吸(APGAR)评分等次要结局的影响无统计学意义。结论:补充l -精氨酸可有效降低子痫前期患者的收缩压和舒张压。然而，它对产妇和新生儿的结局没有明显的影响。
{"title":"Effects of L-arginine on preeclampsia risks and maternal and neonatal outcomes: A systematic review and meta-analysis","authors":"Shonitha Sagadevan, Oorvashree Sri Hari, M. Sirajudeen, G. Ramalingam, R. Basutkar","doi":"10.4103/2305-0500.331261","DOIUrl":"https://doi.org/10.4103/2305-0500.331261","url":null,"abstract":"Objective: To summarize whether the supplementation of L-arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal outcomes. Methods: Studies conducted from the past 17 years (1999 to 2016). were referred from database like Cochrane Central Registry of Controlled Trials (CENTRAL), Scopus, Google Scholar and PubMed. Out of 134 studies, 7 studies were included. L-arginine versus placebo was considered for quantitative analysis. Modified Cochrane data extraction form was used to collect the data. The risk of bias was assessed using Cochrane’s risk of bias assessment tool in RevMan 5.4 and the summary of findings was determined using GradePro software. Results: L-arginine showed a significant reduction of preeclampsia [odds ratio (OR) 0.38; 95% confidence interval (CI) 0.25, 0.58)]. There was a significant reduction in systolic blood pressure [mean difference (MD) -2.47; 95% CI -4.53, -0.42] and diastolic blood pressure (MD -0.97; 95% CI -3.83, 1.89). The effects of L-arginine on secondary outcomes like maternal gestational age, latency, neonatal weight, and appearance, pulse, grimace, activity, respiration (APGAR) score at 1st and 5th minute were not statistically significant. Conclusions: L-arginine supplementation is effective in lowering systolic and diastolic blood pressure of preeclamptic patients. However, it has no noticeable effects on maternal and neonatal outcomes.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"241 - 251"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47397907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.4103/2305-0500.326721
Hanane Derbak, M. Moussaoui, A. Benberkane, A. Ayad
Objective: To determine the in-vitro effect of the total alkaloid extract of Peganum (P.) harmala seeds on ram epididymal sperm. Methods: Semen was divided into six groups according to the following concentrations of the P. harmala total alkaloids: 1, 5, 10, 50, and 100 μg/mL, and the control group. The samples were incubated at ambient temperature (21 °C-24 °C) for 24 h, and analyzed in terms of motility, membrane integrity, and oxidative status. Results: The sperm kinematic parameters, i.e. straight-line velocity, curvilinear velocity, average path velocity, were significantly higher when treated with P. harmala at concentrations ranging from 1 to 10 μg/mL compared to the control group (P<0.05). In addtion, the highest amplitude of the lateral head displacement value was found in the groups treated with concentrations 1 and 5 μg/mL of P. harmala compared to the control group (P<0.05). Total and progressive motilities showed that the extracts at 1, 5, and 10 μg/mL exhibited a high percentage after 24 h of incubation. The effect of P. harmala extracts on the membrane integrity of ram epididymal sperm was concentration-dependent and significantly different compared to the control group (P<0.05). Non-significantly lower lipid peroxidation levels were observed after 24 h of incubation of ram epididymal sperm treated with concentrations 1, 5, and 10 μg/mL of P. harmala extracts compared to the control group (P>0.05). Conclusions: Low concentrations (1-10 μg/mL) of P. harmala extracts stimulate sperm motility, preserve membrane integrity and protect ram spermatozoa from lipid peroxidation.
{"title":"In-vitro effect of Peganum harmala total alkaloids on spermatozoa quality and oxidative stress of epididymal ram semen","authors":"Hanane Derbak, M. Moussaoui, A. Benberkane, A. Ayad","doi":"10.4103/2305-0500.326721","DOIUrl":"https://doi.org/10.4103/2305-0500.326721","url":null,"abstract":"Objective: To determine the in-vitro effect of the total alkaloid extract of Peganum (P.) harmala seeds on ram epididymal sperm. Methods: Semen was divided into six groups according to the following concentrations of the P. harmala total alkaloids: 1, 5, 10, 50, and 100 μg/mL, and the control group. The samples were incubated at ambient temperature (21 °C-24 °C) for 24 h, and analyzed in terms of motility, membrane integrity, and oxidative status. Results: The sperm kinematic parameters, i.e. straight-line velocity, curvilinear velocity, average path velocity, were significantly higher when treated with P. harmala at concentrations ranging from 1 to 10 μg/mL compared to the control group (P<0.05). In addtion, the highest amplitude of the lateral head displacement value was found in the groups treated with concentrations 1 and 5 μg/mL of P. harmala compared to the control group (P<0.05). Total and progressive motilities showed that the extracts at 1, 5, and 10 μg/mL exhibited a high percentage after 24 h of incubation. The effect of P. harmala extracts on the membrane integrity of ram epididymal sperm was concentration-dependent and significantly different compared to the control group (P<0.05). Non-significantly lower lipid peroxidation levels were observed after 24 h of incubation of ram epididymal sperm treated with concentrations 1, 5, and 10 μg/mL of P. harmala extracts compared to the control group (P>0.05). Conclusions: Low concentrations (1-10 μg/mL) of P. harmala extracts stimulate sperm motility, preserve membrane integrity and protect ram spermatozoa from lipid peroxidation.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"232 - 238"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49661863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.4103/2305-0500.326720
Anjaneyababu Banavath, S. Srinivasa
Objective: To study the effect of mobile emitted radio frequency electromagnetic radiation (RF-EMR) on sperm parameters (sperm count, viability, motility, progressivity, and morphology) and ameliorative effect of pomegranate juice in rats. Methods: Thirty male Sprague Dawley rats were divided into five groups (n=6 in each group). Group I was neither exposed to RF-EMR nor given pomegranate juice, group II, III and IV were exposed to mobile emitted RF-EMR for 60 min/day for 90 days. After 90-day exposure to RF-EMR, group III was supplemented with pomegranate juice for 90 days (1 mL/day) and group IV was allowed to recover for 90 days without supplementation of pomegranate juice. Group V was supplemented with pomegranate juice for 90 days without exposure to RF-EMR. At the end of intervention, epididymal sperm parameters (sperm count, viability, motility, progressivity, and morphology) were measured. Results: The microscopic examination of sperm parameters such as sperm count, sperm viability, sperm motility, progressivity were significantly decreased in group II (the mobile RF-EMR group) compared to group I (the control group) (P<0.05). In addition, sperm morphology was also significantly altered (abnormal) in group II compared to group I (P<0.05). However, the sperm parameters including sperm morphology were significantly altered in group III (mobile RF-EMR + pomegranate juice) compared to group II (P<0.05). The sperm parameters including sperm morphology were not significantly altered in group IV (the mobile RF-EMR recovery group) compared to group II (P>0.05). The sperm parameters were non-significantly increased in group V (the pomegranate juice group) compared to group I (P>0.05). Conclusions: Mobile RF-EMR exposure reduces the sperm parameters, which, however, can be reversed by treatment with pomegranate juice, indicating that pomegranate juice can be used as a nutritional supplement to improve sperm quality.
{"title":"Ameliorative effect of Punica granatum on sperm parameters in rats exposed to mobile radioelectromagnetic radiation","authors":"Anjaneyababu Banavath, S. Srinivasa","doi":"10.4103/2305-0500.326720","DOIUrl":"https://doi.org/10.4103/2305-0500.326720","url":null,"abstract":"Objective: To study the effect of mobile emitted radio frequency electromagnetic radiation (RF-EMR) on sperm parameters (sperm count, viability, motility, progressivity, and morphology) and ameliorative effect of pomegranate juice in rats. Methods: Thirty male Sprague Dawley rats were divided into five groups (n=6 in each group). Group I was neither exposed to RF-EMR nor given pomegranate juice, group II, III and IV were exposed to mobile emitted RF-EMR for 60 min/day for 90 days. After 90-day exposure to RF-EMR, group III was supplemented with pomegranate juice for 90 days (1 mL/day) and group IV was allowed to recover for 90 days without supplementation of pomegranate juice. Group V was supplemented with pomegranate juice for 90 days without exposure to RF-EMR. At the end of intervention, epididymal sperm parameters (sperm count, viability, motility, progressivity, and morphology) were measured. Results: The microscopic examination of sperm parameters such as sperm count, sperm viability, sperm motility, progressivity were significantly decreased in group II (the mobile RF-EMR group) compared to group I (the control group) (P<0.05). In addition, sperm morphology was also significantly altered (abnormal) in group II compared to group I (P<0.05). However, the sperm parameters including sperm morphology were significantly altered in group III (mobile RF-EMR + pomegranate juice) compared to group II (P<0.05). The sperm parameters including sperm morphology were not significantly altered in group IV (the mobile RF-EMR recovery group) compared to group II (P>0.05). The sperm parameters were non-significantly increased in group V (the pomegranate juice group) compared to group I (P>0.05). Conclusions: Mobile RF-EMR exposure reduces the sperm parameters, which, however, can be reversed by treatment with pomegranate juice, indicating that pomegranate juice can be used as a nutritional supplement to improve sperm quality.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"10 1","pages":"225 - 231"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43806576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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