Chronic and repeated sun exposure causes photoaging skin that includes solar lentigines, wrinkles, changes of texture, benign tumors, and cutaneous cancers. Various symptoms of photoaging have been a great concern in dermatology. Photoprotection using sunscreens is recommended to prevent these signs. Two measures, sun protection factor (SPF) for UVB and protection grade of UVA (PA) for UVA, are described on the label of sunscreens. Our recent investigation revealed defects in the correct knowledge of SPF and PA and a relationship between freckles and sun-exposure history. Education in the appropriate use of sunscreens and the significance of SPF and PA is needed. Solar lentigines on the face decrease quality of life. Previous laser therapies cause erosion and crusts with downtime for the treatment of pigmentary lesions. Then, intense pulsed light (IPL) sources have been developed as noninvasive and nonablative modalities for facial solar lentigines. We demonstrated clinical effectiveness of an IPL source for solar lentigines and ephelides on the face with well tolerability. Then, we performed a histopathological study that indicated IPL produced highly selective photothemolysis of melanin pigment in the lesions of solar lentigines, leading to the clinical improvement. Moreover, we showed clinical effects of a novel IPL source on solar lentigines and ephelides. In the future, phototherapy including IPL sources will develop with more effectiveness and safety.
{"title":"Protection and Therapy of Photoaging","authors":"A. Kawada","doi":"10.3793/JAAM.8.88","DOIUrl":"https://doi.org/10.3793/JAAM.8.88","url":null,"abstract":"Chronic and repeated sun exposure causes photoaging skin that includes solar lentigines, wrinkles, changes of texture, benign tumors, and cutaneous cancers. Various symptoms of photoaging have been a great concern in dermatology. Photoprotection using sunscreens is recommended to prevent these signs. Two measures, sun protection factor (SPF) for UVB and protection grade of UVA (PA) for UVA, are described on the label of sunscreens. Our recent investigation revealed defects in the correct knowledge of SPF and PA and a relationship between freckles and sun-exposure history. Education in the appropriate use of sunscreens and the significance of SPF and PA is needed. Solar lentigines on the face decrease quality of life. Previous laser therapies cause erosion and crusts with downtime for the treatment of pigmentary lesions. Then, intense pulsed light (IPL) sources have been developed as noninvasive and nonablative modalities for facial solar lentigines. We demonstrated clinical effectiveness of an IPL source for solar lentigines and ephelides on the face with well tolerability. Then, we performed a histopathological study that indicated IPL produced highly selective photothemolysis of melanin pigment in the lesions of solar lentigines, leading to the clinical improvement. Moreover, we showed clinical effects of a novel IPL source on solar lentigines and ephelides. In the future, phototherapy including IPL sources will develop with more effectiveness and safety.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"67 1","pages":"88-91"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86842760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Unno, Hiroyuki Yamamoto, Toshiya Ohtaki, Y. Ishikawa, Shigenori Noda, Ken-ichi Maeda, Keisuke Fujitani, Hideaki Miyazaki, Fumiyo Takabayashi, Toru Sasaki, M. Hoshino
Objective: We previously found that green tea catechins (GT-catechin) decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10). To clarify the effect of GT-catechin on suppression of brain dysfunction, we compare the effect on learning ability among several catechins and examined the essential intake period for prevention of brain dysfunction.Methods: Male SAMP10 mice were allowed free access to water containing epigallocatechin gallate (EGCG, 0.06 mg/ml), epigallocatechin (EGC, 0.03 mg/ml), GT-catechin (0.2 mg/ml), or green tea extract (0.66 mg/ml). Learning ability of mice was measured using a step-through passive avoidance task.Results: SAMP10 mice exhibit brain dysfunction with aging. However, learning ability was significantly higher in mice that drank GT-catechin and EGCG than same-aged control mice that drank water. EGCG was an important component, but EGC had no effect on learning ability. The learning ability was significantly improved in mice that ingested EGCG for > 5 months, and tended to improve in mice that ingested EGCG for 2 or 3 months. Next, the level of synaptophysin, a marker of presynapse, tended to be higher in mice that ingested EGCG but not in mice that ingested EGC. The levels of synaptophysin were significantly higher in mice ingested GT-catechin and green tea extract than control mice.Conclusion: The intake of EGCG, the major catechin in green tea, but not EGC, suppressed age-related brain dysfunction. The effective intake period of EGCG was > 5 months for suppression of brain dysfunction.
{"title":"Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction","authors":"K. Unno, Hiroyuki Yamamoto, Toshiya Ohtaki, Y. Ishikawa, Shigenori Noda, Ken-ichi Maeda, Keisuke Fujitani, Hideaki Miyazaki, Fumiyo Takabayashi, Toru Sasaki, M. Hoshino","doi":"10.3793/JAAM.8.75","DOIUrl":"https://doi.org/10.3793/JAAM.8.75","url":null,"abstract":"Objective: We previously found that green tea catechins (GT-catechin) decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10). To clarify the effect of GT-catechin on suppression of brain dysfunction, we compare the effect on learning ability among several catechins and examined the essential intake period for prevention of brain dysfunction.Methods: Male SAMP10 mice were allowed free access to water containing epigallocatechin gallate (EGCG, 0.06 mg/ml), epigallocatechin (EGC, 0.03 mg/ml), GT-catechin (0.2 mg/ml), or green tea extract (0.66 mg/ml). Learning ability of mice was measured using a step-through passive avoidance task.Results: SAMP10 mice exhibit brain dysfunction with aging. However, learning ability was significantly higher in mice that drank GT-catechin and EGCG than same-aged control mice that drank water. EGCG was an important component, but EGC had no effect on learning ability. The learning ability was significantly improved in mice that ingested EGCG for > 5 months, and tended to improve in mice that ingested EGCG for 2 or 3 months. Next, the level of synaptophysin, a marker of presynapse, tended to be higher in mice that ingested EGCG but not in mice that ingested EGC. The levels of synaptophysin were significantly higher in mice ingested GT-catechin and green tea extract than control mice.Conclusion: The intake of EGCG, the major catechin in green tea, but not EGC, suppressed age-related brain dysfunction. The effective intake period of EGCG was > 5 months for suppression of brain dysfunction.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"42 1","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89725117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ayabe, J. Aoki, H. Kumahara, K. Ishii, Y. Yonei, Hiroaki Tanaka
Purpose: The purpose of the present investigation was to examine the validity and reliability of the simple moderate to vigorous physical activity (MVPA) monitor (NL-1000; NEWLIFESTYLES, MO) during treadmill walking and running.Methods: A total of 70 men and women, between 22 to 76 years of age, participated in the present investigation. Subjects continuously wore the NL-1000 device on their waist. The NL-1000 calculated the time spent in MVPA corresponding to › 3 METs. All subjects walked at speeds of 40 to 115 m.min-1 and ran at a speed of 130 m.min-1 on a motor driven treadmill for four minutes. Furthermore, eight of all subjects performed a second experiment in order to assess the reliability of NL-1000.Results: The MVPA measured by the NL-1000 (MVPAped) significantly increased at a walking at the speed of faster than 85m.min-1 (p ‹ 0.05). Of the actual exercise time, MVPAped corresponded to › 90% of the actual exercise time in › 85 m.min-1 or faster speed. A multiple regression analysis showed that gender, body mass index, and age did not significantly affect the accuracy of MVPAped, and the treadmill speed came out significant parameter of MVPAped. The MVPAped did not differ significantly within the first and second experiment, furthermore, the results correlated significantly (r = 0.956, p ‹ 0.001).Conclusion: These results indicate that simple MVPA monitor would be a valid instrument to during the treadmill walking and running.
{"title":"Effects of Age and Body Mass Index on Accuracy of Simple Moderate Vigorous Physical Activity Monitor Under Controlled Condition","authors":"M. Ayabe, J. Aoki, H. Kumahara, K. Ishii, Y. Yonei, Hiroaki Tanaka","doi":"10.3793/JAAM.8.41","DOIUrl":"https://doi.org/10.3793/JAAM.8.41","url":null,"abstract":"Purpose: The purpose of the present investigation was to examine the validity and reliability of the simple moderate to vigorous physical activity (MVPA) monitor (NL-1000; NEWLIFESTYLES, MO) during treadmill walking and running.Methods: A total of 70 men and women, between 22 to 76 years of age, participated in the present investigation. Subjects continuously wore the NL-1000 device on their waist. The NL-1000 calculated the time spent in MVPA corresponding to › 3 METs. All subjects walked at speeds of 40 to 115 m.min-1 and ran at a speed of 130 m.min-1 on a motor driven treadmill for four minutes. Furthermore, eight of all subjects performed a second experiment in order to assess the reliability of NL-1000.Results: The MVPA measured by the NL-1000 (MVPAped) significantly increased at a walking at the speed of faster than 85m.min-1 (p ‹ 0.05). Of the actual exercise time, MVPAped corresponded to › 90% of the actual exercise time in › 85 m.min-1 or faster speed. A multiple regression analysis showed that gender, body mass index, and age did not significantly affect the accuracy of MVPAped, and the treadmill speed came out significant parameter of MVPAped. The MVPAped did not differ significantly within the first and second experiment, furthermore, the results correlated significantly (r = 0.956, p ‹ 0.001).Conclusion: These results indicate that simple MVPA monitor would be a valid instrument to during the treadmill walking and running.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"24 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90817735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akemi Ozeki, A. Muramoto, Yumiko Tanmatsu, Taizou Kishimoto, Akio Shinozaki, K. Tsushita
Body weight gain or obesity has been reported to increase the risk of developing lifestyle-related diseases. However, few longitudinal studies have examined the relationship between body shape change and health, and the few that do exist used body shapes reported by the subjects.We investigated whether or not maintaining a “youthful” body shape helps prevent the development of lifestyle-related diseases in healthy women. Changes in body shape in a group of healthy women were evaluated over 30 years starting from sometime in their 20s by visually judging pictures of the subjects and using body shape vectors. Subjects were classified into two groups: a group of 12 (mean age: 44.9±5.1 years) who were judged to have maintained their youthful body shape (maintained group) and a group of 16 (mean age: 47.5±6.1 years) who were judged not to have maintained their shape (non-maintained group). Body size and composition measurements were then compared with biochemical markers that measure the risk of developing lifestyle-related diseases. Mean body weight in the maintained group was 4.0 kg less than in the non-maintained group, while body fat mass was 4.6 kg less. In addition, the maintained group showed better scores for biochemical and pulse wave velocity tests.Taken together, our results suggest that women who maintain their youthful body shape into their later years have a reduced risk of the lifestyle-related diseases that frequently accompany age.
{"title":"Does Maintenance of Body Shape Contribute to Health in Middle-Aged Women?","authors":"Akemi Ozeki, A. Muramoto, Yumiko Tanmatsu, Taizou Kishimoto, Akio Shinozaki, K. Tsushita","doi":"10.3793/JAAM.8.53","DOIUrl":"https://doi.org/10.3793/JAAM.8.53","url":null,"abstract":"Body weight gain or obesity has been reported to increase the risk of developing lifestyle-related diseases. However, few longitudinal studies have examined the relationship between body shape change and health, and the few that do exist used body shapes reported by the subjects.We investigated whether or not maintaining a “youthful” body shape helps prevent the development of lifestyle-related diseases in healthy women. Changes in body shape in a group of healthy women were evaluated over 30 years starting from sometime in their 20s by visually judging pictures of the subjects and using body shape vectors. Subjects were classified into two groups: a group of 12 (mean age: 44.9±5.1 years) who were judged to have maintained their youthful body shape (maintained group) and a group of 16 (mean age: 47.5±6.1 years) who were judged not to have maintained their shape (non-maintained group). Body size and composition measurements were then compared with biochemical markers that measure the risk of developing lifestyle-related diseases. Mean body weight in the maintained group was 4.0 kg less than in the non-maintained group, while body fat mass was 4.6 kg less. In addition, the maintained group showed better scores for biochemical and pulse wave velocity tests.Taken together, our results suggest that women who maintain their youthful body shape into their later years have a reduced risk of the lifestyle-related diseases that frequently accompany age.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"46 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82830662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycation end products (AGEs), which may accumulate in tissue. AGEs may also bind to a receptor for AGEs (RAGE), thus inducing inflammatory changes in skin and other tissues. The concept of glycation stress includes cellular and tissue responses to reducing sugars and aldehydes, not just to the production of AGEs. Glycation stress may be induced and affected by many factors, including exposure to ultraviolet light, which drastically intensifies AGE accumulation. AGEs modify skin collagen by reducing skin elasticity, and one result is wrinkle formation. AGEs accumulated in skin may be detected using auto-fluorescence (AF); our data from 136 healthy Japanese females shows the AF level is correlated with age. Glycation stress, and subsequently skin aging, may be reduced by managing levels of blood glucose, low-density lipoprotein cholesterol, and triglyceride through an appropriate diet, lifestyle, and intake of anti-glycation materials such as AGE generation inhibitors, AGE decomposers, and AGE receptor antagonists. Study of glycation stress may help identify new anti-aging treatments.
{"title":"Glycation Stress and Photo-Aging in Skin","authors":"M. Ichihashi, M. Yagi, K. Nomoto, Y. Yonei","doi":"10.3793/JAAM.8.23","DOIUrl":"https://doi.org/10.3793/JAAM.8.23","url":null,"abstract":"This article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycation end products (AGEs), which may accumulate in tissue. AGEs may also bind to a receptor for AGEs (RAGE), thus inducing inflammatory changes in skin and other tissues. The concept of glycation stress includes cellular and tissue responses to reducing sugars and aldehydes, not just to the production of AGEs. Glycation stress may be induced and affected by many factors, including exposure to ultraviolet light, which drastically intensifies AGE accumulation. AGEs modify skin collagen by reducing skin elasticity, and one result is wrinkle formation. AGEs accumulated in skin may be detected using auto-fluorescence (AF); our data from 136 healthy Japanese females shows the AF level is correlated with age. Glycation stress, and subsequently skin aging, may be reduced by managing levels of blood glucose, low-density lipoprotein cholesterol, and triglyceride through an appropriate diet, lifestyle, and intake of anti-glycation materials such as AGE generation inhibitors, AGE decomposers, and AGE receptor antagonists. Study of glycation stress may help identify new anti-aging treatments.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"28 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86555180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Satoko Shimasaki, Midori Kubota, M. Yoshitomi, K. Takagi, K. Suda, K. Mera, Yukio Fujiwara, R. Nagai
Objective: Advanced glycation end products (AGEs) accumulate in tissues due to aging, diabetic complications, and atherosclerosis. The acid lability of Nω-carboxymethylarginine (CMA) present in glycated collagen has hampered detailed studies on its function and in vivo localization. In the present study, we analyzed the effects of collagen glycation on human dermal fibroblast (HDF) function. We also took advantage of Klotho-deficient mice ( kl/kl), which undergo accelerated senescence, to determine glycated collagen’s tissue localization. Methods: Bovine type I collagen was incubated with ribose, and CMA formation was measured by enzyme-linked immunosorbent assay (ELISA). We measured the contraction of 3-dimensional matrix gels (3D gel), consisting of either native or glycated collagens, after culture with HDFs. CMA accumulation in Klotho-deficient mouse skin was measured by immunohistochemical staining. Results: When collagen was incubated with ribose, CMA levels increased with time. In our HDF culture system, gels prepared with native, but not glycated collagen, contracted with time. In Klotho-deficient mice, CMA localized to the extracellular dermal matrix. Conclusions: Here we show that CMA may provide a marker for collagen glycation, which may adversely affect HDFs’ growth and survival. Therefore, treatment with AGE inhibitors might help prevent pathologies associated with AGE formation.
{"title":"Nω-(carboxymethyl)arginine Accumulates in Glycated Collagen and Klotho-deficient Mouse Skin","authors":"Satoko Shimasaki, Midori Kubota, M. Yoshitomi, K. Takagi, K. Suda, K. Mera, Yukio Fujiwara, R. Nagai","doi":"10.3793/JAAM.8.82","DOIUrl":"https://doi.org/10.3793/JAAM.8.82","url":null,"abstract":"Objective: Advanced glycation end products (AGEs) accumulate in tissues due to aging, diabetic complications, and atherosclerosis. The acid lability of Nω-carboxymethylarginine (CMA) present in glycated collagen has hampered detailed studies on its function and in vivo localization. In the present study, we analyzed the effects of collagen glycation on human dermal fibroblast (HDF) function. We also took advantage of Klotho-deficient mice ( kl/kl), which undergo accelerated senescence, to determine glycated collagen’s tissue localization. Methods: Bovine type I collagen was incubated with ribose, and CMA formation was measured by enzyme-linked immunosorbent assay (ELISA). We measured the contraction of 3-dimensional matrix gels (3D gel), consisting of either native or glycated collagens, after culture with HDFs. CMA accumulation in Klotho-deficient mouse skin was measured by immunohistochemical staining. Results: When collagen was incubated with ribose, CMA levels increased with time. In our HDF culture system, gels prepared with native, but not glycated collagen, contracted with time. In Klotho-deficient mice, CMA localized to the extracellular dermal matrix. Conclusions: Here we show that CMA may provide a marker for collagen glycation, which may adversely affect HDFs’ growth and survival. Therefore, treatment with AGE inhibitors might help prevent pathologies associated with AGE formation.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"20 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83348474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Miyazaki, Y. Yonei, Yoriko Azuma, H. Chiba, Koichiro Hayashi, K. Yamatsu, K. Ishii
Objective: To study the relationship between the change in the number of steps taken and brachial-ankle pulse wave velocity (baPWV) during a long-term pedometer-based physical activity program in healthy older adults. Methods: Sixty older adults participated in this 17-week program. Each subject was provided with a pedometer and was given a goal to walk a set number of steps/day. After five subjects were excluded because of insufficient step data, data from 55 subjects (19 men and 36 women; age range: 65–79 years, mean age: 71.3±3.7 years; mean body mass index [BMI]: 24.1±8.8 kg/m 2 ) were analyzed. Subjects were checked before and after the study. Each subject was informed of his or her vascular age, calculated from baPWV, at the start of the study. Results: Subjects were divided into four groups based on the results of baPWV. The group in which baPWV improved above a selected cut-off value (1,700 cm/s) revealed the largest increase in steps/day among groups. This increase (4837.7±1868.7 steps) was larger than in groups in which baPWV remained low (1406.7±2402.1 steps, p=0.036) and high (1678.2±2871.4 steps, p=0.059). In any group, age or initial steps/day did not influence the change in steps. Subjects classified as having an older vascular age than the actual age on the basis of initial baPWV walked further. Conclusion: An increase in steps/day might improve baPWV. Although walking is a low intensity physical activity, it can have an anti-atherosclerosis effect.
{"title":"Relationship Between the Change in Daily Step Count and Brachial-Ankle Wave Velocity During a Pedometer-Based Physical Activity Program for Older Adults","authors":"R. Miyazaki, Y. Yonei, Yoriko Azuma, H. Chiba, Koichiro Hayashi, K. Yamatsu, K. Ishii","doi":"10.3793/JAAM.8.35","DOIUrl":"https://doi.org/10.3793/JAAM.8.35","url":null,"abstract":"Objective: To study the relationship between the change in the number of steps taken and brachial-ankle pulse wave velocity (baPWV) during a long-term pedometer-based physical activity program in healthy older adults. Methods: Sixty older adults participated in this 17-week program. Each subject was provided with a pedometer and was given a goal to walk a set number of steps/day. After five subjects were excluded because of insufficient step data, data from 55 subjects (19 men and 36 women; age range: 65–79 years, mean age: 71.3±3.7 years; mean body mass index [BMI]: 24.1±8.8 kg/m 2 ) were analyzed. Subjects were checked before and after the study. Each subject was informed of his or her vascular age, calculated from baPWV, at the start of the study. Results: Subjects were divided into four groups based on the results of baPWV. The group in which baPWV improved above a selected cut-off value (1,700 cm/s) revealed the largest increase in steps/day among groups. This increase (4837.7±1868.7 steps) was larger than in groups in which baPWV remained low (1406.7±2402.1 steps, p=0.036) and high (1678.2±2871.4 steps, p=0.059). In any group, age or initial steps/day did not influence the change in steps. Subjects classified as having an older vascular age than the actual age on the basis of initial baPWV walked further. Conclusion: An increase in steps/day might improve baPWV. Although walking is a low intensity physical activity, it can have an anti-atherosclerosis effect.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"25 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83724034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fumihiko Yoshino, Ayaka Yoshida, Shuta Sugiyama, Fumiaki Tokutomi, C. Miyamoto, Y. Maehata, Kyo Kobayashi, S. Wada-Takahashi, T. Maetani, Eizo Okada, Yasue Okada, T. Komatsu, Shun-suke Takahashi, Jian-xin Wan, Masaichi-chang-il Lee
Objective: In this study, the antioxidant properties of peptide from boiled fish paste (fish products peptide; FPP) supplement were investigated in middle-aged subjects. Methods: The subjects who participated in this study were men and premenopausal women, aged between 30 and 50 years (39.6 ± 5.5 years). The subjects consumed 10 tablets/day (containing 0.9 g of total fish peptide) for 60 days. Pre- and post-supplementation, subjects underwent analysis by physical measurement, completed the Anti-Aging QOL Common Questionnaire, and were examined in terms of vascular features, blood biochemical and uric characteristics, and hormone and oxidative stress markers. Results: After 60 days of supplementation with FPP, significant improvement was observed in serum lipid peroxide (LPO) (–16.2 %, p = 0.001). In terms of oxidative markers, 8-hydroxy-2’-deoxyguanosine (8-OHdG) showed a tendency to decrease; in addition, potential antioxidant (PAO) and serum total antioxidant status (STAS), as antioxidant properties, showed slight increases. Furthermore, highsensitivity C-reactive protein (hs-CRP) also exhibited a tendency to decrease. Discussion: The results show that FPP might contribute to the prevention of lifestyle-related disease by regulating the balance of oxidative stress and improving arteriosclerosis with high oxidative stress.
{"title":"Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects","authors":"Fumihiko Yoshino, Ayaka Yoshida, Shuta Sugiyama, Fumiaki Tokutomi, C. Miyamoto, Y. Maehata, Kyo Kobayashi, S. Wada-Takahashi, T. Maetani, Eizo Okada, Yasue Okada, T. Komatsu, Shun-suke Takahashi, Jian-xin Wan, Masaichi-chang-il Lee","doi":"10.3793/JAAM.8.48","DOIUrl":"https://doi.org/10.3793/JAAM.8.48","url":null,"abstract":"Objective: In this study, the antioxidant properties of peptide from boiled fish paste (fish products peptide; FPP) supplement were investigated in middle-aged subjects. Methods: The subjects who participated in this study were men and premenopausal women, aged between 30 and 50 years (39.6 ± 5.5 years). The subjects consumed 10 tablets/day (containing 0.9 g of total fish peptide) for 60 days. Pre- and post-supplementation, subjects underwent analysis by physical measurement, completed the Anti-Aging QOL Common Questionnaire, and were examined in terms of vascular features, blood biochemical and uric characteristics, and hormone and oxidative stress markers. Results: After 60 days of supplementation with FPP, significant improvement was observed in serum lipid peroxide (LPO) (–16.2 %, p = 0.001). In terms of oxidative markers, 8-hydroxy-2’-deoxyguanosine (8-OHdG) showed a tendency to decrease; in addition, potential antioxidant (PAO) and serum total antioxidant status (STAS), as antioxidant properties, showed slight increases. Furthermore, highsensitivity C-reactive protein (hs-CRP) also exhibited a tendency to decrease. Discussion: The results show that FPP might contribute to the prevention of lifestyle-related disease by regulating the balance of oxidative stress and improving arteriosclerosis with high oxidative stress.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"84 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89023687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mari Ogura, M. Yagi, K. Nomoto, R. Miyazaki, Masaya Kongoji, Show Watanabe, U. Hamada, Y. Yonei
Objective: Previous epidemiological surveys of diet indicated a potential relationship between fruit intake and the pathogenesis of lifestyle-related disease. Recent reports indicate grapefruit (GF) may affect sugar metabolism. The present study measured glucose, triglyceride and insulin levels in human blood after GF ingestion with and without other foods.Methods: Twelve healthy, non-smoking female volunteers, non-obese (age 40.5 ± 4.2 years old, BMI 22.0 ± 0.9) were provided with five different breakfasts on successive days: GF, bread or fried vegetables alone, GF + bread, GF + fried vegetables. In meals that included GF, the GF was eaten before the bread or fried vegetables. Blood samples were taken after meals to measure plasma glucose, immuno reactive insulin (IRI), triglyceride and vitamin C.Results: Plasma glucose following a meal of bread or fried vegetables or a meal of bread and fried vegetables with GF was similar. Insulin secretion was slower after a meal of GF alone compared to bread alone (p < 0.001) and the area under curve (AUC) of glucose per carbohydrate intake was lower when GF was eaten prior to bread or fried vegetables than after a single intake of bread or fried vegetables alone (p < 0.001). The AUC of triglyceride after a prior intake of GF before fried vegetables was slower than that after an intake of fried vegetables alone (p < 0.05). Blood vitamin C concentration increased after GF intake (p < 0.001).Conclusion: GF contains saccharides and a variety of dietary elements, including fiber, vitamins, citric acid, naringenin and bergamottin. It is possible that these compounds may affect sugar and lipid metabolism.
{"title":"Effect of Grapefruit Intake on Postprandial Plasma Glucose","authors":"Mari Ogura, M. Yagi, K. Nomoto, R. Miyazaki, Masaya Kongoji, Show Watanabe, U. Hamada, Y. Yonei","doi":"10.3793/JAAM.8.60","DOIUrl":"https://doi.org/10.3793/JAAM.8.60","url":null,"abstract":"Objective: Previous epidemiological surveys of diet indicated a potential relationship between fruit intake and the pathogenesis of lifestyle-related disease. Recent reports indicate grapefruit (GF) may affect sugar metabolism. The present study measured glucose, triglyceride and insulin levels in human blood after GF ingestion with and without other foods.Methods: Twelve healthy, non-smoking female volunteers, non-obese (age 40.5 ± 4.2 years old, BMI 22.0 ± 0.9) were provided with five different breakfasts on successive days: GF, bread or fried vegetables alone, GF + bread, GF + fried vegetables. In meals that included GF, the GF was eaten before the bread or fried vegetables. Blood samples were taken after meals to measure plasma glucose, immuno reactive insulin (IRI), triglyceride and vitamin C.Results: Plasma glucose following a meal of bread or fried vegetables or a meal of bread and fried vegetables with GF was similar. Insulin secretion was slower after a meal of GF alone compared to bread alone (p < 0.001) and the area under curve (AUC) of glucose per carbohydrate intake was lower when GF was eaten prior to bread or fried vegetables than after a single intake of bread or fried vegetables alone (p < 0.001). The AUC of triglyceride after a prior intake of GF before fried vegetables was slower than that after an intake of fried vegetables alone (p < 0.05). Blood vitamin C concentration increased after GF intake (p < 0.001).Conclusion: GF contains saccharides and a variety of dietary elements, including fiber, vitamins, citric acid, naringenin and bergamottin. It is possible that these compounds may affect sugar and lipid metabolism.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"16 1","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84829910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Nakajima, T. Yasuda, Yoshiaki Sato, T. Morita, T. Yamasoba
As demographic aging continues in Japan, the number of very elderly individuals aged 75 years or older is increasing rapidly, as is the number of bedridden, elderly individuals, with ramifications extending to economic problems such as health care costs and insurance for long-term care. Consequently, there is a great importance to questions of how to prevent age-related loss of muscle (sarcopenia) to prevent bedridden states, and further to improve quality of life (QOL) and maintain active lifestyles. Exercise is the most effective means for preventing and addressing sarcopenia. Regular exercise is also reported to prevent progression of arteriosclerosis, prevent lifestyle diseases, and delay onset of dementia. However, the effects of exercise are known to differ substantially for different types of exercise. Regular walking and other aerobic exercise improves cardiovascular endurance, but among the elderly, loss of muscular strength, muscular atrophy, and other diminished physical functions have implications for falling and fractures, and it is not uncommon to see a consequent aggravation of disuse syndrome due to inactivity, leading to a bedridden state. In this light, strength training is also important for elderly individuals, to increase muscular strength and muscle mass. It is also highly important for elderly individuals to eat a diet, particularly amino acids, that enhances the effects of exercise. Here we present an overview of aerobic exercise, resistance training, and “kaatsu training” (i.e., training under pressure-restricted blood flow to the extremities) representing anti-aging exercise methods. We likewise discuss the importance of diet for exercise.
{"title":"Effects of Exercise and Anti-Aging","authors":"T. Nakajima, T. Yasuda, Yoshiaki Sato, T. Morita, T. Yamasoba","doi":"10.3793/JAAM.8.92","DOIUrl":"https://doi.org/10.3793/JAAM.8.92","url":null,"abstract":"As demographic aging continues in Japan, the number of very elderly individuals aged 75 years or older is increasing rapidly, as is the number of bedridden, elderly individuals, with ramifications extending to economic problems such as health care costs and insurance for long-term care. Consequently, there is a great importance to questions of how to prevent age-related loss of muscle (sarcopenia) to prevent bedridden states, and further to improve quality of life (QOL) and maintain active lifestyles. Exercise is the most effective means for preventing and addressing sarcopenia. Regular exercise is also reported to prevent progression of arteriosclerosis, prevent lifestyle diseases, and delay onset of dementia. However, the effects of exercise are known to differ substantially for different types of exercise. Regular walking and other aerobic exercise improves cardiovascular endurance, but among the elderly, loss of muscular strength, muscular atrophy, and other diminished physical functions have implications for falling and fractures, and it is not uncommon to see a consequent aggravation of disuse syndrome due to inactivity, leading to a bedridden state. In this light, strength training is also important for elderly individuals, to increase muscular strength and muscle mass. It is also highly important for elderly individuals to eat a diet, particularly amino acids, that enhances the effects of exercise. Here we present an overview of aerobic exercise, resistance training, and “kaatsu training” (i.e., training under pressure-restricted blood flow to the extremities) representing anti-aging exercise methods. We likewise discuss the importance of diet for exercise.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"87 1 1","pages":"92-102"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84026364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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