Y. Kaji, T. Oshika, Y. Takazawa, M. Fukayama, N. Fujii
Age-related macular degeneration has become a leading cause of blindness in most developed countries worldwide. In the early phase of the disease, abnormal, yellow-colored material called “drusen” appears between the retinal pigment epithelial cells and Bruch's membrane. Immunohistochemical studies have confirmed that drusen contain D-amino acid-containing proteins and advanced glycation end products. In addition, retinal pigment epithelial cells express a receptor for AGEs (RAGE). These findings indicate that persistent interaction between AGEs and RAGE is involved in the development of age-related macular degeneration.
{"title":"Pathological Role of D-amino Acid-Containing Proteins and Advanced Glycation End Products in the Development of Age-Related Macular Degeneration","authors":"Y. Kaji, T. Oshika, Y. Takazawa, M. Fukayama, N. Fujii","doi":"10.3793/JAAM.7.107","DOIUrl":"https://doi.org/10.3793/JAAM.7.107","url":null,"abstract":"Age-related macular degeneration has become a leading cause of blindness in most developed countries worldwide. In the early phase of the disease, abnormal, yellow-colored material called “drusen” appears between the retinal pigment epithelial cells and Bruch's membrane. Immunohistochemical studies have confirmed that drusen contain D-amino acid-containing proteins and advanced glycation end products. In addition, retinal pigment epithelial cells express a receptor for AGEs (RAGE). These findings indicate that persistent interaction between AGEs and RAGE is involved in the development of age-related macular degeneration.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"13 1","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79106460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mastication is a complicated movement generated from a neural population in the brainstem and a neural network involving several brain regions. Recently, attention has been focused on the relationship between mastication and age-related decline in human cognitive function, but the neural mechanisms underlying this association remain unknown. In this article, we review research on the effect of mastication based on data obtained using event-related potentials (ERPs), including the P300 component and contingent negative variation (CNV), motor-related cortical potentials (MRCPs), and reaction time (RT) as behavioral data. The peak latency of P300 and RT clearly shortened with the repetition of sessions in Mastication, but not in Control, Jaw Movement, or Finger Tapping. The mean amplitude of CNV differed between the Mastication and Control conditions with the repetition of sessions. By contrast, there was no significant difference in the amplitude of MRCP between Mastication and Control in any of the sessions. These results suggest that mastication is associated with cognitive processing rather than movement-related processing in the human brain. We believe that non-invasive recording methods, such as electroencephalography (EEG), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI), and near-infrared spectroscopy (NIRS), will supply valuable evidence in support of a positive relationship between mastication and cognition.
{"title":"Effect of Mastication on Human Brain Activity","authors":"K. Sakamoto, H. Nakata, M. Yumoto, R. Kakigi","doi":"10.3793/JAAM.7.153","DOIUrl":"https://doi.org/10.3793/JAAM.7.153","url":null,"abstract":"Mastication is a complicated movement generated from a neural population in the brainstem and a neural network involving several brain regions. Recently, attention has been focused on the relationship between mastication and age-related decline in human cognitive function, but the neural mechanisms underlying this association remain unknown. In this article, we review research on the effect of mastication based on data obtained using event-related potentials (ERPs), including the P300 component and contingent negative variation (CNV), motor-related cortical potentials (MRCPs), and reaction time (RT) as behavioral data. The peak latency of P300 and RT clearly shortened with the repetition of sessions in Mastication, but not in Control, Jaw Movement, or Finger Tapping. The mean amplitude of CNV differed between the Mastication and Control conditions with the repetition of sessions. By contrast, there was no significant difference in the amplitude of MRCP between Mastication and Control in any of the sessions. These results suggest that mastication is associated with cognitive processing rather than movement-related processing in the human brain. We believe that non-invasive recording methods, such as electroencephalography (EEG), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI), and near-infrared spectroscopy (NIRS), will supply valuable evidence in support of a positive relationship between mastication and cognition.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"1 1","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83014601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Yukishita, Keiko K. Lee, Sungdo Kim, Yu Yumoto, A. Kobayashi, T. Shirasawa, Hiroyuki Kobayashi
{"title":"Age and Sex-Dependent Alterations in Heart Rate Variability","authors":"T. Yukishita, Keiko K. Lee, Sungdo Kim, Yu Yumoto, A. Kobayashi, T. Shirasawa, Hiroyuki Kobayashi","doi":"10.3793/JAAM.7.94","DOIUrl":"https://doi.org/10.3793/JAAM.7.94","url":null,"abstract":"","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"12 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78219546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Motoko Ishikawa, Sachi Ishikawa, H. Kamata, Yoshiaki Akihiro, U. Hamada, Y. Yonei
Objective: We conducted an anti-aging medical checkup and health promotion program, including facial mimetic muscle training, in residents of a geriatric medical care facility. Here, we evaluate the physical and mental effects of these activities.Methods: Three male and 16 female residents (83.7±6.8 years, BMI 22.2±3.0) underwent occupational therapy, with the addition of facial mimetic muscle training with a medical device, “M Patakara”, for 3.0 — 4.5 minutes four times per day for 24 weeks. Efficacy was evaluated by anti-aging medical checkup before and after the study.Results: The Anti-Aging QOL Common Questionnaire (AAQol) showed a significant improvement in the symptom scores of “anorexia”, “early satiety”, “epigastralgia”, “constipation”, “headache”, “dizziness”, and “arthralgia” (p‹0.05). Laboratory results showed significant changes in LDL cholesterol (111.6±24.8 mg/dl → 120.2±27.5mg/dl, p=0.022) and IGF-I (123.2±50.9ng/ml → 109.6±55.5ng/ml, p=0.005) at 24 weeks. Serum cortisol (11.7±3.8μg/dl → 15.6±5.3μg/dl, p=0.001) significantly increased while DHEA-s/cortisol ratio did not change. The Wisconsin card sorting test showed a significant reduction in total errors (32.6±4.6 → 27.8 ±7.5, p=0.022) and unique errors (5.2±5.1 → 1.9 ±2.7, p=0.026). Body composition analysis (Physion MD) revealed a decrease in muscle mass in the upper arms (0.50±0.14kg → 0.45±0.12kg, p=0.005) and lower limbs (4.4±1.2kg → 4.1±1.0kg, p=0.006). There was no significant change in vascular age by fingertip acceleration plethysmogram (SDP-100) or in osteo-sono-assessment index of the calcaneus by ultrasonography (AOS-100NW). Saliva secretion increased significantly, from 8.0±5.0 mm/min to 12.6±2.3 mm/min (p‹0.001) by the coffee filter method. Labial closure strength and electromyographic activity of the facial mimetic muscles increased significantly. No serious adverse event occurred during or after the study.Conclusion: This health promotion program with facial mimetic muscle training improved saliva secretion and subjective symptoms, indicating that it improved QOL in these aged facility patients. On anti-aging medical checkup, however, it was ineffective in preventing sufficiently the muscle weakening.
{"title":"Efficacy of a Health Promotion Program with Facial Mimetic Muscle Training in Residents of a Medical Care Facility for the Elderly","authors":"Motoko Ishikawa, Sachi Ishikawa, H. Kamata, Yoshiaki Akihiro, U. Hamada, Y. Yonei","doi":"10.3793/JAAM.7.120","DOIUrl":"https://doi.org/10.3793/JAAM.7.120","url":null,"abstract":"Objective: We conducted an anti-aging medical checkup and health promotion program, including facial mimetic muscle training, in residents of a geriatric medical care facility. Here, we evaluate the physical and mental effects of these activities.Methods: Three male and 16 female residents (83.7±6.8 years, BMI 22.2±3.0) underwent occupational therapy, with the addition of facial mimetic muscle training with a medical device, “M Patakara”, for 3.0 — 4.5 minutes four times per day for 24 weeks. Efficacy was evaluated by anti-aging medical checkup before and after the study.Results: The Anti-Aging QOL Common Questionnaire (AAQol) showed a significant improvement in the symptom scores of “anorexia”, “early satiety”, “epigastralgia”, “constipation”, “headache”, “dizziness”, and “arthralgia” (p‹0.05). Laboratory results showed significant changes in LDL cholesterol (111.6±24.8 mg/dl → 120.2±27.5mg/dl, p=0.022) and IGF-I (123.2±50.9ng/ml → 109.6±55.5ng/ml, p=0.005) at 24 weeks. Serum cortisol (11.7±3.8μg/dl → 15.6±5.3μg/dl, p=0.001) significantly increased while DHEA-s/cortisol ratio did not change. The Wisconsin card sorting test showed a significant reduction in total errors (32.6±4.6 → 27.8 ±7.5, p=0.022) and unique errors (5.2±5.1 → 1.9 ±2.7, p=0.026). Body composition analysis (Physion MD) revealed a decrease in muscle mass in the upper arms (0.50±0.14kg → 0.45±0.12kg, p=0.005) and lower limbs (4.4±1.2kg → 4.1±1.0kg, p=0.006). There was no significant change in vascular age by fingertip acceleration plethysmogram (SDP-100) or in osteo-sono-assessment index of the calcaneus by ultrasonography (AOS-100NW). Saliva secretion increased significantly, from 8.0±5.0 mm/min to 12.6±2.3 mm/min (p‹0.001) by the coffee filter method. Labial closure strength and electromyographic activity of the facial mimetic muscles increased significantly. No serious adverse event occurred during or after the study.Conclusion: This health promotion program with facial mimetic muscle training improved saliva secretion and subjective symptoms, indicating that it improved QOL in these aged facility patients. On anti-aging medical checkup, however, it was ineffective in preventing sufficiently the muscle weakening.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"93 1","pages":"120-128"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79581047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yonei, R. Miyazaki, Yoko Takahashi, H. Takahashi, K. Nomoto, M. Yagi, H. Kawai, M. Kubo, N. Matsuura
Objective: We conducted a double-blind, placebo-controlled, parallel group study to assess the anti-glycation effect of mixed herbal extract (MHE) in individuals with pre-diabetes mellitus. MHE was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). We also assessed whether MHE showed favorable effects on one's quality of life (QOL).Design: The subjects consisted of 26 volunteers (male: 21; female: 5; age: 50.5 ± 8.5 years) with pre- diabetes mellitus (HbA1c: 5.5 - 6.7%). They were divided into two groups, the Test Group (13 subjects, age: 52.8 ± 8.2 years) and the Control Group (12 subjects, age: 49.3 ± 7.8 years). The Test Group was administered 1,200 mg of MHE (solid substance) per day for 8 weeks. The Control Group was administered a placebo.Results: The inter-group analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, “muscular pain/stiffness”, “headache”, “easily angered”, “reluctance to talk with others”, “memory lapse”, and “inability to readily make judgments” was significantly improved in the Test Group (p ‹ 0.05). In terms of sugar metabolism, no significant variation was observed in fasting blood glucose, HbA1c, glycoalbumin, and insulin. A significant variation was not observed in the Test Group with regard to 3-deoxyglucosone (3DG), an intermediate of glycation, and Ne-(carboxymethyl)lysine (CML) and pentosidine, advanced glycation endproducts (AGEs), in blood after 8 weeks. However, in the subjects with HbA1c of equal to or higher than 5.9%, the subclass inter-group analysis showed that the supplementation of MHE significantly inhibited (p ‹ 0.05) an increase of CML in the Test Group, while CML increased in the Control Group. There was no significant variation in the Test Group regarding the oxidative stress markers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane in urine. The skin elasticity index (R2) obtained by using the cutometer started to decrease significantly in the Control Group after 4 weeks (p ‹ 0.05), while the index showed a tendency that the skin elasticity was successfully maintained in the Test Group. There was no adverse event which was associated with the test product.Conclusion: These results suggest that MHE may improve the symptoms related to QOL as well as inhibit the generation of CML, one of AGEs, in individuals with abnormal sugar metabolism. Furthermore, the 8 weeks supplementation of MHE was considered to be safe.
{"title":"Anti-Glycation Effect of Mixed Herbal Extract in Individuals with Pre-Diabetes Mellitus","authors":"Y. Yonei, R. Miyazaki, Yoko Takahashi, H. Takahashi, K. Nomoto, M. Yagi, H. Kawai, M. Kubo, N. Matsuura","doi":"10.3793/JAAM.7.26","DOIUrl":"https://doi.org/10.3793/JAAM.7.26","url":null,"abstract":"Objective: We conducted a double-blind, placebo-controlled, parallel group study to assess the anti-glycation effect of mixed herbal extract (MHE) in individuals with pre-diabetes mellitus. MHE was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). We also assessed whether MHE showed favorable effects on one's quality of life (QOL).Design: The subjects consisted of 26 volunteers (male: 21; female: 5; age: 50.5 ± 8.5 years) with pre- diabetes mellitus (HbA1c: 5.5 - 6.7%). They were divided into two groups, the Test Group (13 subjects, age: 52.8 ± 8.2 years) and the Control Group (12 subjects, age: 49.3 ± 7.8 years). The Test Group was administered 1,200 mg of MHE (solid substance) per day for 8 weeks. The Control Group was administered a placebo.Results: The inter-group analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, “muscular pain/stiffness”, “headache”, “easily angered”, “reluctance to talk with others”, “memory lapse”, and “inability to readily make judgments” was significantly improved in the Test Group (p ‹ 0.05). In terms of sugar metabolism, no significant variation was observed in fasting blood glucose, HbA1c, glycoalbumin, and insulin. A significant variation was not observed in the Test Group with regard to 3-deoxyglucosone (3DG), an intermediate of glycation, and Ne-(carboxymethyl)lysine (CML) and pentosidine, advanced glycation endproducts (AGEs), in blood after 8 weeks. However, in the subjects with HbA1c of equal to or higher than 5.9%, the subclass inter-group analysis showed that the supplementation of MHE significantly inhibited (p ‹ 0.05) an increase of CML in the Test Group, while CML increased in the Control Group. There was no significant variation in the Test Group regarding the oxidative stress markers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane in urine. The skin elasticity index (R2) obtained by using the cutometer started to decrease significantly in the Control Group after 4 weeks (p ‹ 0.05), while the index showed a tendency that the skin elasticity was successfully maintained in the Test Group. There was no adverse event which was associated with the test product.Conclusion: These results suggest that MHE may improve the symptoms related to QOL as well as inhibit the generation of CML, one of AGEs, in individuals with abnormal sugar metabolism. Furthermore, the 8 weeks supplementation of MHE was considered to be safe.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"36 1","pages":"26-35"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90384923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Oda, Hideki Tachimoto, M. Kishi, Takayuki Kaga, M. Ichihashi
The lipid matrix in the stratum corneum is important to the barrier function of mammalian skin. Ceramides are main components of intercellular lipids in the stratum corneum and play an essential role in skin barrier function. Moreover, recent investigations have demonstrated improvement in skin barrier properties after oral intake of ceramides of plant origin in mice and healthy adults. However, beneficial effects on skin barrier function by oral intake of ceramides other than those of plant origin have not been reported.It is known that acetic acid bacteria accumulate intracellular ceramides. Therefore, we examined the dietary effect of ceramide-containing acetic acid bacteria on skin barrier function. Studied were 3 groups, each comprised of 20 healthy adults with awareness of dry skin. The control group was given a placebo, the low acetic acid bacteria group [low-dose group] was given 55.6 mg dry acetic acid bacteria containing 400 μg ceramide, and the high acetic acid bacteria group [high-dose group] was administered 111.1 mg dry acetic acid bacteria containing 800 μg ceramide per day for 8 weeks. Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were measured as indexes of skin barrier function on the cheek, upper inner arm and back of the neck of all study subjects. The most marked effect was on the cheek, the area most exposed. On the cheek, the TEWL value increased significantly on week 4 after starting administration in the control group, but remained at the baseline level in both the low-dose and high-dose groups. In both the low-dose and high-dose groups, TEWL values decreased significantly on week 6. The SCH value increased significantly after 6 weeks administration in the control group, whereas in both the low-dose and high-dose groups the SCH value increased significantly after just 4 weeks of intake. This increase occurred within a shorter period than in the control group. These results suggest that oral intake of ceramide-containing acetic acid bacteria effects to maintain skin barrier function in healthy adults with awareness of dry skin.
{"title":"Effect of Oral Intake of Ceramide-Containing Acetic Acid Bcteria on Skin Barrier Function","authors":"T. Oda, Hideki Tachimoto, M. Kishi, Takayuki Kaga, M. Ichihashi","doi":"10.3793/JAAM.7.50","DOIUrl":"https://doi.org/10.3793/JAAM.7.50","url":null,"abstract":"The lipid matrix in the stratum corneum is important to the barrier function of mammalian skin. Ceramides are main components of intercellular lipids in the stratum corneum and play an essential role in skin barrier function. Moreover, recent investigations have demonstrated improvement in skin barrier properties after oral intake of ceramides of plant origin in mice and healthy adults. However, beneficial effects on skin barrier function by oral intake of ceramides other than those of plant origin have not been reported.It is known that acetic acid bacteria accumulate intracellular ceramides. Therefore, we examined the dietary effect of ceramide-containing acetic acid bacteria on skin barrier function. Studied were 3 groups, each comprised of 20 healthy adults with awareness of dry skin. The control group was given a placebo, the low acetic acid bacteria group [low-dose group] was given 55.6 mg dry acetic acid bacteria containing 400 μg ceramide, and the high acetic acid bacteria group [high-dose group] was administered 111.1 mg dry acetic acid bacteria containing 800 μg ceramide per day for 8 weeks. Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were measured as indexes of skin barrier function on the cheek, upper inner arm and back of the neck of all study subjects. The most marked effect was on the cheek, the area most exposed. On the cheek, the TEWL value increased significantly on week 4 after starting administration in the control group, but remained at the baseline level in both the low-dose and high-dose groups. In both the low-dose and high-dose groups, TEWL values decreased significantly on week 6. The SCH value increased significantly after 6 weeks administration in the control group, whereas in both the low-dose and high-dose groups the SCH value increased significantly after just 4 weeks of intake. This increase occurred within a shorter period than in the control group. These results suggest that oral intake of ceramide-containing acetic acid bacteria effects to maintain skin barrier function in healthy adults with awareness of dry skin.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"51 1","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91053291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of this study was to establish a long-term pedometer-based physical activity program for a group of community-dwelling older people and examine the effects on health and Anti-Aging medical indicators using an Anti-Aging medical checkup. We report here on the findings in the first 5 months (21 weeks) of the in-progress program.Methods: Subjects in the present study were 43 healthy middle-aged and older adults (17 men, 26 women, mean age: 69.0±5.9 years; mean body mass index: 22.9±3.0kg/m2) in the Shimogyo district of Kyoto-city, Japan. Each subject was provided a pedometer and instructed to walk with a goal of steps per day. Further, to motivate subjects, newsletters were delivered every four weeks. Checkups were conducted at the start of the study and 21 weeks later.Results: The average number of steps taken during the first five months of the study was significantly higher than at the start of the study (at 5 months: increase of 1,506.1 steps, p‹0.001). Two subjects dropped out of the study. Significant improvements were seen in body weight (p‹0.05), BMI (p‹0.01), waist circumference (p‹0.001), fasting plasma glucose (p‹0.05), insulin (p‹0.05), and bone density increased significantly (p‹0.05). With regard to stress indicators, DHEA-s (p‹0.01) and DHEA-s/cortisol (p‹0.01) increased, and cortisol (p‹0.01) decreased. With regard to Anti-Aging indicators, DHEA-s increased (p‹0.01), functioning as a hormonal age indicator, and bone density increased, functioning as a bone age indicator. A significant positive correlation was observed between change in steps/day and change in IGF-I concentration(r=0.382, p‹0.05). The functional ages did not change. Subjects were divided into 3 groups based on the gap between their functional age and actual age. In regard to vascular age, the group with the lowest (diagnosed younger) age gap tended to walk more than the group with the highest (diagnosed older) age gap. (p=0.095).Conclusion: Although ours is a relatively simple program, significant improvements were noted in many health and Anti-Aging indicators among community-dwelling older adults. IGF-I concentration increased in parallel with increase of steps. Further, our study had a low drop-out rate. Given that all of our subjects were healthy from study initiation, functional ages did not change. However, telling subjects their vascular age may be related to the increase of steps/day. This program is on-going, and therefore further reports are expected to follow.
{"title":"Community Medicine and Anti-Aging:","authors":"R. Miyazaki, K. Ishii, H. Ichikawa, Y. Yonei","doi":"10.3793/JAAM.7.143","DOIUrl":"https://doi.org/10.3793/JAAM.7.143","url":null,"abstract":"Objective: The purpose of this study was to establish a long-term pedometer-based physical activity program for a group of community-dwelling older people and examine the effects on health and Anti-Aging medical indicators using an Anti-Aging medical checkup. We report here on the findings in the first 5 months (21 weeks) of the in-progress program.Methods: Subjects in the present study were 43 healthy middle-aged and older adults (17 men, 26 women, mean age: 69.0±5.9 years; mean body mass index: 22.9±3.0kg/m2) in the Shimogyo district of Kyoto-city, Japan. Each subject was provided a pedometer and instructed to walk with a goal of steps per day. Further, to motivate subjects, newsletters were delivered every four weeks. Checkups were conducted at the start of the study and 21 weeks later.Results: The average number of steps taken during the first five months of the study was significantly higher than at the start of the study (at 5 months: increase of 1,506.1 steps, p‹0.001). Two subjects dropped out of the study. Significant improvements were seen in body weight (p‹0.05), BMI (p‹0.01), waist circumference (p‹0.001), fasting plasma glucose (p‹0.05), insulin (p‹0.05), and bone density increased significantly (p‹0.05). With regard to stress indicators, DHEA-s (p‹0.01) and DHEA-s/cortisol (p‹0.01) increased, and cortisol (p‹0.01) decreased. With regard to Anti-Aging indicators, DHEA-s increased (p‹0.01), functioning as a hormonal age indicator, and bone density increased, functioning as a bone age indicator. A significant positive correlation was observed between change in steps/day and change in IGF-I concentration(r=0.382, p‹0.05). The functional ages did not change. Subjects were divided into 3 groups based on the gap between their functional age and actual age. In regard to vascular age, the group with the lowest (diagnosed younger) age gap tended to walk more than the group with the highest (diagnosed older) age gap. (p=0.095).Conclusion: Although ours is a relatively simple program, significant improvements were noted in many health and Anti-Aging indicators among community-dwelling older adults. IGF-I concentration increased in parallel with increase of steps. Further, our study had a low drop-out rate. Given that all of our subjects were healthy from study initiation, functional ages did not change. However, telling subjects their vascular age may be related to the increase of steps/day. This program is on-going, and therefore further reports are expected to follow.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"17 1","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87283485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mio Hori, S. Kishimoto, Yu Tezuka, H. Nishigori, K. Nomoto, U. Hamada, Y. Yonei
Objective: To determine the effect of beet extract on skin elasticity in female volunteers with dry skin and in human dermal fibroblasts.Method: To assess the effects of oral administration of glucosyl ceramide contained in beet extract (beet ceramide), we conducted an 8-week double-blind comparison study with 35 females (mean age: 40.9±4.2 years) with mild subjective symptoms of dry skin and declining keratin moisture levels. The compound was administered as glucosyl ceramide at 0, 0.6, or 1.8 mg/day to 3 groups (n=11, 12, 12, respectively).Results: Scores improved significantly for the following subjective skin symptoms: “concerned about dull skin,” “concerned about spots or freckles,” “sticky, oily skin,” “coarse and desiccated skin,” “not elastic, not glossy,” “concerned about rough skin,” “bags under eyes.” In addition, perspiration levels improved. The skin elasticity test (Cutometer) indicated that the elasticity index (R2 and R7) improved in a dose-dependent manner. However, we were unable to confirm the effects of ceramide on increasing skin moisture as reported in previous studies. In experiments involving human dermal fibroblasts, addition of beet ceramide promoted fibronectin synthesis and mRNA expression but had no effect on fibroblast proliferation or collagen synthesis.Conclusion: Results from clinical trials and experiments suggested that oral ingestion of beet ceramide may stimulate intracellular signals and exert favorable effects on the extracellular matrix, including the induction of fibronectin synthesis. In addition, we confirmed the safety of administering beet ceramide to humans.
{"title":"Double-Blind Study on Effects of Glucosyl Ceramide in Beet Extract on Skin Elasticity and Fibronectin Production in Human Dermal Fibroblasts","authors":"Mio Hori, S. Kishimoto, Yu Tezuka, H. Nishigori, K. Nomoto, U. Hamada, Y. Yonei","doi":"10.3793/JAAM.7.129","DOIUrl":"https://doi.org/10.3793/JAAM.7.129","url":null,"abstract":"Objective: To determine the effect of beet extract on skin elasticity in female volunteers with dry skin and in human dermal fibroblasts.Method: To assess the effects of oral administration of glucosyl ceramide contained in beet extract (beet ceramide), we conducted an 8-week double-blind comparison study with 35 females (mean age: 40.9±4.2 years) with mild subjective symptoms of dry skin and declining keratin moisture levels. The compound was administered as glucosyl ceramide at 0, 0.6, or 1.8 mg/day to 3 groups (n=11, 12, 12, respectively).Results: Scores improved significantly for the following subjective skin symptoms: “concerned about dull skin,” “concerned about spots or freckles,” “sticky, oily skin,” “coarse and desiccated skin,” “not elastic, not glossy,” “concerned about rough skin,” “bags under eyes.” In addition, perspiration levels improved. The skin elasticity test (Cutometer) indicated that the elasticity index (R2 and R7) improved in a dose-dependent manner. However, we were unable to confirm the effects of ceramide on increasing skin moisture as reported in previous studies. In experiments involving human dermal fibroblasts, addition of beet ceramide promoted fibronectin synthesis and mRNA expression but had no effect on fibroblast proliferation or collagen synthesis.Conclusion: Results from clinical trials and experiments suggested that oral ingestion of beet ceramide may stimulate intracellular signals and exert favorable effects on the extracellular matrix, including the induction of fibronectin synthesis. In addition, we confirmed the safety of administering beet ceramide to humans.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"32 1","pages":"129-142"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83140992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Ryo, A. Ito, Rie Takatori, Y. Tai, Junji Tokunaga, K. Arikawa, Takashi Yamada, Keiko Shinpo, H. Yasuda, I. Saito
14 To examine possible association between dental amalgam fillings and mercury burden, we measured the mercury concentrations in scalp hair samples from 74 female Japanese subjects aged 26-64 years who had a dietary habit of little fish-consumption. The hair mercury concentrations in the subjects with multiple amalgam fillings were significantly higher than those in the subjects with no amalgam fillings, and correlated with the number of amalgam fillings in the following regression equation: log Hg = 0.084 amalgam fillings + 3.377 (r = 0.339, p = 0.003). In addition, multiple regression analysis demonstrated that the hair mercury concentrations were significantly correlated with the amalgam fillings (r = 0.292; p = 0.014) and age (r = 0.284; p = 0.017) but not significantly with the body mass index (r = 0.060). A regression equation of log Hg = 0.071 amalgam fillings + 0.011 age + 0.006 BMI + 2.72 was obtained (r = 0.447), with 0.200 of the determination coefficient. These findings suggest that the dental amalgam fillings positively influence mercury accumulation in the hair and also, probably, in the body. Abstract Koufuchi Ryo 1), Atsuko Ito 1), Rie Takatori 1), Yoshinori Tai 2), Junji Tokunaga 1), Kazumune Arikawa 2), Takashi Yamada 1), Keiko Shinpo 1), Hiroshi Yasuda 3), Ichiro Saito 1)
{"title":"Correlation Between Mercury Concentrations in Hair and Dental Amalgam Fillings","authors":"K. Ryo, A. Ito, Rie Takatori, Y. Tai, Junji Tokunaga, K. Arikawa, Takashi Yamada, Keiko Shinpo, H. Yasuda, I. Saito","doi":"10.3793/JAAM.7.14","DOIUrl":"https://doi.org/10.3793/JAAM.7.14","url":null,"abstract":"14 To examine possible association between dental amalgam fillings and mercury burden, we measured the mercury concentrations in scalp hair samples from 74 female Japanese subjects aged 26-64 years who had a dietary habit of little fish-consumption. The hair mercury concentrations in the subjects with multiple amalgam fillings were significantly higher than those in the subjects with no amalgam fillings, and correlated with the number of amalgam fillings in the following regression equation: log Hg = 0.084 amalgam fillings + 3.377 (r = 0.339, p = 0.003). In addition, multiple regression analysis demonstrated that the hair mercury concentrations were significantly correlated with the amalgam fillings (r = 0.292; p = 0.014) and age (r = 0.284; p = 0.017) but not significantly with the body mass index (r = 0.060). A regression equation of log Hg = 0.071 amalgam fillings + 0.011 age + 0.006 BMI + 2.72 was obtained (r = 0.447), with 0.200 of the determination coefficient. These findings suggest that the dental amalgam fillings positively influence mercury accumulation in the hair and also, probably, in the body. Abstract Koufuchi Ryo 1), Atsuko Ito 1), Rie Takatori 1), Yoshinori Tai 2), Junji Tokunaga 1), Kazumune Arikawa 2), Takashi Yamada 1), Keiko Shinpo 1), Hiroshi Yasuda 3), Ichiro Saito 1)","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"1 1","pages":"14-17"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74137988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
100 During last 30 years, apheresis technologies had helped to treat many diseases by removing pathological macromolecules or pathological cells from patient’s blood. They included the cryofiltration to remove cryogel and the thermofiltration to remove LDL cholesterol. Unfortunately during these 30 years, developments of new apheresis technologies were not actively pursued by apheresis practitioners in the world including our group. Some diseases once treated by apheresis procedures were also shrank substantially. However, we believed that apheresis therapy had many possibilities to treat the major disease categories including heart diseases, diabetes mellitus and cancer. Even aging process might be able to be prevented by apheresis therapy. In this paper, we should go over current membrane apheresis technologies and should introduce our concept of “Juzo” as an Anti-Aging artificial organ which was presented in 1995. Then we should introduce the new types of the 2nd generation apheresis technologies by referencing recent papers which supported our study directions. The new technologies included in this paper were the cryoaggregate filtration to remove pathological globulin molecules for the treatment of cardiomyopathic diseases, cryoreactive albumin removal apheresis (CRARA) for the treatment and for the prevention of diabetic complications of diabetic patients by removing pathological albumin and bioincompatible apheresis system for cancer treatment. In conclusion, apheresis therapies could remove pathological molecules accumulated excessively in the aging living body. The return to the normal levels of these molecules might be an effective interventional method as an Anti-Aging medical therapy.
{"title":"Can an Apheresis Therapy become an Effective Method for Anti-Aging Medicine?","authors":"H. Miyamoto, Y. Nosé","doi":"10.3793/JAAM.7.100","DOIUrl":"https://doi.org/10.3793/JAAM.7.100","url":null,"abstract":"100 During last 30 years, apheresis technologies had helped to treat many diseases by removing pathological macromolecules or pathological cells from patient’s blood. They included the cryofiltration to remove cryogel and the thermofiltration to remove LDL cholesterol. Unfortunately during these 30 years, developments of new apheresis technologies were not actively pursued by apheresis practitioners in the world including our group. Some diseases once treated by apheresis procedures were also shrank substantially. However, we believed that apheresis therapy had many possibilities to treat the major disease categories including heart diseases, diabetes mellitus and cancer. Even aging process might be able to be prevented by apheresis therapy. In this paper, we should go over current membrane apheresis technologies and should introduce our concept of “Juzo” as an Anti-Aging artificial organ which was presented in 1995. Then we should introduce the new types of the 2nd generation apheresis technologies by referencing recent papers which supported our study directions. The new technologies included in this paper were the cryoaggregate filtration to remove pathological globulin molecules for the treatment of cardiomyopathic diseases, cryoreactive albumin removal apheresis (CRARA) for the treatment and for the prevention of diabetic complications of diabetic patients by removing pathological albumin and bioincompatible apheresis system for cancer treatment. In conclusion, apheresis therapies could remove pathological molecules accumulated excessively in the aging living body. The return to the normal levels of these molecules might be an effective interventional method as an Anti-Aging medical therapy.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"17 1","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82458449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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