M. Ayabe, Y. Yonei, R. Miyazaki, H. Kumahara, N. Sakane, K. Ishii
Purpose: To examine the relationship between the functional age (FA) and the objectively measured daily physical activity (PA). Methods: The subjects of the present investigation were 15 males and 22 females (68±6 yr.). The Anti-Aging-Dock determined the 5 components of FA (Bone age; BA, Hormone-age; HA, Muscle-age; MA, Nervous system-age; NA, Vascular-age; VA). Each participant wore an electronic pedometer (HJ-720IT, Omron Corporation, Kyoto-city, Kyoto Japan) in order to determine daily number of steps (STEPday) and the time and steps for PA lasting longer >10-min at >60 steps·min –1 of the step rate (Bouttime and Boutstep). The HA was evaluated by using the standard aging curve of serum DHEA-s and IGF-I concentration. Result: Simple correlation coefficient showed that the HA significantly associated with STEP day and Boutstep in female subjects (p 10-min may be an effective PA to protect the age-associated changes in hormonal functions.
{"title":"Functional Age and Bouts of Physical Activity in Middle-Aged to Older Japanese Adults; Yurin-Study","authors":"M. Ayabe, Y. Yonei, R. Miyazaki, H. Kumahara, N. Sakane, K. Ishii","doi":"10.3793/JAAM.8.103","DOIUrl":"https://doi.org/10.3793/JAAM.8.103","url":null,"abstract":"Purpose: To examine the relationship between the functional age (FA) and the objectively measured daily physical activity (PA). Methods: The subjects of the present investigation were 15 males and 22 females (68±6 yr.). The Anti-Aging-Dock determined the 5 components of FA (Bone age; BA, Hormone-age; HA, Muscle-age; MA, Nervous system-age; NA, Vascular-age; VA). Each participant wore an electronic pedometer (HJ-720IT, Omron Corporation, Kyoto-city, Kyoto Japan) in order to determine daily number of steps (STEPday) and the time and steps for PA lasting longer >10-min at >60 steps·min –1 of the step rate (Bouttime and Boutstep). The HA was evaluated by using the standard aging curve of serum DHEA-s and IGF-I concentration. Result: Simple correlation coefficient showed that the HA significantly associated with STEP day and Boutstep in female subjects (p 10-min may be an effective PA to protect the age-associated changes in hormonal functions.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"32 1","pages":"103-107"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91027636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The application of clinical nutrition to ageing populations requires the development of a high degree of multidisciplinarity with its related scholarship and skills. Clinical Nutrition is the prevention, diagnosis and management of nutritionally-related health problems (NRHP) by qualified health care practitioners. It may be practised by those specialised in it or in the course of work from primary to tertiary health care, in various major (e.g., internal medicine, surgery, obstetrics & gynecology, and psychiatry) disciplines and in sub-specialties and for various age groups , notably children (paediatrics) and the elderly (geriatrics). With population ageing, the field of geriatric nutrition has grown. Its underpinning science and scholarship require contributions from ageing biology, the medical sciences, epidemiology, sociology, and bioethics; it must also be coordinated with the food system to ensure food security; its practitioners need an intimate knowledge of communities and households. It may be considered in several domains Geriatric Nutritional Epidemiology, Preventive geriatric nutrition, Diagnostic geriatric nutrition, Management geriatric nutrition- care, therapeutics, palliation and Nutrition and Ageing Economics and Community Geriatric Nutrition. Effective geriatric nutrition is a team and community endeavour.
{"title":"Clinical Nutrition for an Ageing Population","authors":"M. Wahlqvist, Meei-shyuan Lee","doi":"10.3793/JAAM.8.30","DOIUrl":"https://doi.org/10.3793/JAAM.8.30","url":null,"abstract":"The application of clinical nutrition to ageing populations requires the development of a high degree of multidisciplinarity with its related scholarship and skills. Clinical Nutrition is the prevention, diagnosis and management of nutritionally-related health problems (NRHP) by qualified health care practitioners. It may be practised by those specialised in it or in the course of work from primary to tertiary health care, in various major (e.g., internal medicine, surgery, obstetrics & gynecology, and psychiatry) disciplines and in sub-specialties and for various age groups , notably children (paediatrics) and the elderly (geriatrics). With population ageing, the field of geriatric nutrition has grown. Its underpinning science and scholarship require contributions from ageing biology, the medical sciences, epidemiology, sociology, and bioethics; it must also be coordinated with the food system to ensure food security; its practitioners need an intimate knowledge of communities and households. It may be considered in several domains Geriatric Nutritional Epidemiology, Preventive geriatric nutrition, Diagnostic geriatric nutrition, Management geriatric nutrition- care, therapeutics, palliation and Nutrition and Ageing Economics and Community Geriatric Nutrition. Effective geriatric nutrition is a team and community endeavour.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"2015 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82617542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yonei, T. Kitano, Mari Ogura, Mio Hori, Miwako Watanabe, U. Hamada, S. Matsuoka, E. Ono, T. Ohno, M. Shen
Objective: The purpose of the present study was to elucidate the effects and safety of Cistanche deserticola Y. C. Ma extract (CDX), which was given to elderly persons as a 12-week oral administration via CDX containing health food.Methods: A non-controlled open study was conducted with 25 elderly persons, without severe illness. Participants were given test product containing 100 mg of CDX as well as vitamin E, vitamin B6, ubiquinone, zinc and fukoidan, by oral administration for 12 weeks, with examination conducted before and after the study.Results: Subjective symptoms of “tired eyes” and “feeling tired all the time” were significantly improved after 12 weeks. With regard to anthropometric measurements, pulse rate was significantly reduced (−8.0%, p = 0.002). Biochemical examinations showed significant changes in white blood cell count (−14.1%, p ‹ 0.001), platelet count (−4.3%, p = 0.040), albumin (−3.7%, p ‹ 0.001), albumin/globulin ratio (−3.7%, p = 0.016), and fasting blood sugar (−10.2%, p = .039). Immune function was significantly improved with elevation of percentage of CD4 positive cells (6.1%, p = 0.003), CD4/CD8 ratio (20.2%, p = 0.002) and natural killer (NK) cell activity (11.7%, p = 0.024) accompanied by a decrease in percentage of CD8 positive cells (−7.7%, p = 0.022). Arteriosclerosis examinations by fingertip acceleration pulse wave analysis showed significant improvement in vascular age (−4.2%, p = 0.016) and significant decrease in cardio ankle vascular index (CAVI) (right: −10.9%, p ‹ 0.001, left: −12.6%, p ‹0.001).Conclusion: The test product appears to promote quality of life by decreasing fatigue, activating immune function and favorably affecting the vascular system in the elderly. No severe adverse effects were observed during the study.
{"title":"Effects of Health Food Containing Cistanche Deserticola Extract on QOL and Safety in Elderly: An Open Pilot Study of 12-week Oral Treatment","authors":"Y. Yonei, T. Kitano, Mari Ogura, Mio Hori, Miwako Watanabe, U. Hamada, S. Matsuoka, E. Ono, T. Ohno, M. Shen","doi":"10.3793/JAAM.8.7","DOIUrl":"https://doi.org/10.3793/JAAM.8.7","url":null,"abstract":"Objective: The purpose of the present study was to elucidate the effects and safety of Cistanche deserticola Y. C. Ma extract (CDX), which was given to elderly persons as a 12-week oral administration via CDX containing health food.Methods: A non-controlled open study was conducted with 25 elderly persons, without severe illness. Participants were given test product containing 100 mg of CDX as well as vitamin E, vitamin B6, ubiquinone, zinc and fukoidan, by oral administration for 12 weeks, with examination conducted before and after the study.Results: Subjective symptoms of “tired eyes” and “feeling tired all the time” were significantly improved after 12 weeks. With regard to anthropometric measurements, pulse rate was significantly reduced (−8.0%, p = 0.002). Biochemical examinations showed significant changes in white blood cell count (−14.1%, p ‹ 0.001), platelet count (−4.3%, p = 0.040), albumin (−3.7%, p ‹ 0.001), albumin/globulin ratio (−3.7%, p = 0.016), and fasting blood sugar (−10.2%, p = .039). Immune function was significantly improved with elevation of percentage of CD4 positive cells (6.1%, p = 0.003), CD4/CD8 ratio (20.2%, p = 0.002) and natural killer (NK) cell activity (11.7%, p = 0.024) accompanied by a decrease in percentage of CD8 positive cells (−7.7%, p = 0.022). Arteriosclerosis examinations by fingertip acceleration pulse wave analysis showed significant improvement in vascular age (−4.2%, p = 0.016) and significant decrease in cardio ankle vascular index (CAVI) (right: −10.9%, p ‹ 0.001, left: −12.6%, p ‹0.001).Conclusion: The test product appears to promote quality of life by decreasing fatigue, activating immune function and favorably affecting the vascular system in the elderly. No severe adverse effects were observed during the study.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"37 1","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90391655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Male sexual function","authors":"永井 敦","doi":"10.1201/b14726-19","DOIUrl":"https://doi.org/10.1201/b14726-19","url":null,"abstract":"","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"12 1","pages":"478-481"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80024164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human body odor is generated by waste materials present on the skin surface and secretions from the sweat and sebaceous glands. These waste materials are converted to characteristic odorous compounds through oxidative degradation or metabolism by skin microbes. Changes in body odor due to aging relate to the amount and composition of sweat and sebum secreted, as well as gland activity. 2-Nonenal has an unpleasant, greasy, grassy odor and is mainly detected in people aged over 40 years. Generation of 2-nonenal is related to oxidative degradation of ω7 unsaturated fatty acids. Given that body odor may function as a barometer indicating the body's overall health, further understanding of this odor's makeup is important. Here, we define several types of body odor and describe changes in body odor, with a specific focus on 2-nonenal, an odor characteristically associated with aging.
{"title":"Odor Associated with Aging","authors":"Sadahiko Yamazaki, K. Hoshino, M. Kusuhara","doi":"10.3793/JAAM.7.60","DOIUrl":"https://doi.org/10.3793/JAAM.7.60","url":null,"abstract":"Human body odor is generated by waste materials present on the skin surface and secretions from the sweat and sebaceous glands. These waste materials are converted to characteristic odorous compounds through oxidative degradation or metabolism by skin microbes. Changes in body odor due to aging relate to the amount and composition of sweat and sebum secreted, as well as gland activity. 2-Nonenal has an unpleasant, greasy, grassy odor and is mainly detected in people aged over 40 years. Generation of 2-nonenal is related to oxidative degradation of ω7 unsaturated fatty acids. Given that body odor may function as a barometer indicating the body's overall health, further understanding of this odor's makeup is important. Here, we define several types of body odor and describe changes in body odor, with a specific focus on 2-nonenal, an odor characteristically associated with aging.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"82 1","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80231313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
92 Levels of plasma pentosidine, which is one of the advanced glycation end-products (AGEs) of the Maillard reaction, are elevated by the pathogenesis of diabetes 1) and end-stage renal failure 2). A recent study suggested that because plasma pentosidine levels in patients with mild renal dysfunction increase before plasma creatinine levels increase, the measurement of plasma pentosidine level can be a useful clinical marker for the early diagnosis of beginning renal failure 3). Several medical laboratories in Japan have measured the levels of blood AGEs, such as Ne-(carboxymethyl)lysine (CML) and pentosidine, by a competitive enzyme-linked immunosorbent assay (ELISA). According to the authors’ protocol, plasma samples are incubated with proteases for anti-AGE antibodies to assess the intramolecular AGE structures, and are incubated again at 100°C for 15 min 3) to inactivate the protease. However, our previous study demonstrated that CML, a major antigenic AGE structure, is generated from the Amadori products by short-term heating in vitro, demonstrating that CML generated from Amadori products are an artifact of immunochemical detection by heating process 4). Furthermore, Miyata et al. 5) reported that substance(s) with a molecular weight of less than 5,000 Da that are abundantly present in uremic plasma exhibit enhanced pentosidine formation during in vitro incubation of uremic plasma at 37°C, thus strongly demonstrating that pentosidine is also generated by incubation in vitro. To confirm this notion, we conducted additional experiments to clarify whether the pentosidine content measured by high-performance liquid chromatography (HPLC) 6) in blood increases using the same procedure as that used by medical laboratories. As a result, the levels of pentosidine in patients with nondiabetic hemodialysis increased 1.2to 3-fold by heating at 100°C for 15 min compared to unheated samples. Moreover, the increased rate of pentosidine levels generated by the heating process was found to differ between patients. Therefore, the heating process as a pretreatment for pentosidine measurement by competitive ELISA appears to compromise the accuracy of the pentosidine concentration present in plasma. Taken together, previous reports 4,5) and the present study indicate that the level of pentosidine in clinical samples is overestimated by using a heating process. Heating enhances both the oxidative cleavage of Amadori products and the production of α-oxoaldehydes such as glucosone, 3-deoxyglucosone, glyoxal, and methylglyoxal, which were indicated to be important precursors for AGE formation 4). We next measured the inhibitory effects of reduction of Amadori products on CML formation. Because CML is generated from the Amadori compounds by oxidative cleavage, whereas the Amadori compounds reduced into hexitol lysine and glucitol lysine are stable and do not easily generate CML, sodium cyanoborohydride (NaBH3CN) is used for the blood CML analysis using a competitive
{"title":"Heat Treatment Increases the Level of AGEs in Human Blood","authors":"M. Nakano, R. Nagai","doi":"10.3793/JAAM.7.92","DOIUrl":"https://doi.org/10.3793/JAAM.7.92","url":null,"abstract":"92 Levels of plasma pentosidine, which is one of the advanced glycation end-products (AGEs) of the Maillard reaction, are elevated by the pathogenesis of diabetes 1) and end-stage renal failure 2). A recent study suggested that because plasma pentosidine levels in patients with mild renal dysfunction increase before plasma creatinine levels increase, the measurement of plasma pentosidine level can be a useful clinical marker for the early diagnosis of beginning renal failure 3). Several medical laboratories in Japan have measured the levels of blood AGEs, such as Ne-(carboxymethyl)lysine (CML) and pentosidine, by a competitive enzyme-linked immunosorbent assay (ELISA). According to the authors’ protocol, plasma samples are incubated with proteases for anti-AGE antibodies to assess the intramolecular AGE structures, and are incubated again at 100°C for 15 min 3) to inactivate the protease. However, our previous study demonstrated that CML, a major antigenic AGE structure, is generated from the Amadori products by short-term heating in vitro, demonstrating that CML generated from Amadori products are an artifact of immunochemical detection by heating process 4). Furthermore, Miyata et al. 5) reported that substance(s) with a molecular weight of less than 5,000 Da that are abundantly present in uremic plasma exhibit enhanced pentosidine formation during in vitro incubation of uremic plasma at 37°C, thus strongly demonstrating that pentosidine is also generated by incubation in vitro. To confirm this notion, we conducted additional experiments to clarify whether the pentosidine content measured by high-performance liquid chromatography (HPLC) 6) in blood increases using the same procedure as that used by medical laboratories. As a result, the levels of pentosidine in patients with nondiabetic hemodialysis increased 1.2to 3-fold by heating at 100°C for 15 min compared to unheated samples. Moreover, the increased rate of pentosidine levels generated by the heating process was found to differ between patients. Therefore, the heating process as a pretreatment for pentosidine measurement by competitive ELISA appears to compromise the accuracy of the pentosidine concentration present in plasma. Taken together, previous reports 4,5) and the present study indicate that the level of pentosidine in clinical samples is overestimated by using a heating process. Heating enhances both the oxidative cleavage of Amadori products and the production of α-oxoaldehydes such as glucosone, 3-deoxyglucosone, glyoxal, and methylglyoxal, which were indicated to be important precursors for AGE formation 4). We next measured the inhibitory effects of reduction of Amadori products on CML formation. Because CML is generated from the Amadori compounds by oxidative cleavage, whereas the Amadori compounds reduced into hexitol lysine and glucitol lysine are stable and do not easily generate CML, sodium cyanoborohydride (NaBH3CN) is used for the blood CML analysis using a competitive","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"155 1","pages":"92-93"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78001051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Igase, Toru Mizoguchi, Y. Ogushi, T. Miki, A. Ueki
In the “Brain Aging and Nutrition” symposium at the 2010 10th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, three experts were invited to report recent findings on maintenance of brain health. Speaking on “The association of postural instability with brain atrophy/cognitive impairment”, Dr. Michiya Igase (Department of Geriatric Medicine & Neurology, Ehime University Graduate School of Medicine) described the importance of Anti-Aging examination for early discovery and early treatment of decreased cognitive function according to an Anti-Aging examination, particularly stressing on the importance of preventing frailty in the elderly. Dr. Toru Mizoguchi (Shinjuku Mizoguchi Clinic), speaking on “Improved brain function and nutrition”, discussed how low intake of glucose, amino acids, vitamins, and minerals leads to metabolic abnormalities in the brain and low production of neurotransmitters, which can cause depression and many other psychiatric illnesses not only in the elderly, but in middle age too. In “The brain prefers ketones to carbohydrates as an energy source”, Dr. Yoichi Ogushi (Department of Medical Informatics, Tokai University School of Medicine) presented data showing that a ketotic diet, also known as a low-carbohydrate diet (Atkins' or Bernstein's diet), is safe, and, moreover, that ketones are used as an energy source by the brain. This work suggested that advanced glycosylation end product is a risk factor for Alzheimer's and Perkinson's disease, and that glucose is only utilized after keton bodies by the brain. This notion in turn raises the possibility that a ketotic diet may prevent or slow the progression of Alzheimer's disease.Anti-Aging measures above mentioned may play crucial roles in preventing brain atrophy, cognitive impairment, and depression which are closely related to the aging process. Stable energy supply and adequate nutritional distribution to neurons in the brain are keys to maintain brain function through neuronal survival and biosynthesis of neurotransmitters.
{"title":"Brain Aging and Nutrition","authors":"M. Igase, Toru Mizoguchi, Y. Ogushi, T. Miki, A. Ueki","doi":"10.3793/JAAM.7.167","DOIUrl":"https://doi.org/10.3793/JAAM.7.167","url":null,"abstract":"In the “Brain Aging and Nutrition” symposium at the 2010 10th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, three experts were invited to report recent findings on maintenance of brain health. Speaking on “The association of postural instability with brain atrophy/cognitive impairment”, Dr. Michiya Igase (Department of Geriatric Medicine & Neurology, Ehime University Graduate School of Medicine) described the importance of Anti-Aging examination for early discovery and early treatment of decreased cognitive function according to an Anti-Aging examination, particularly stressing on the importance of preventing frailty in the elderly. Dr. Toru Mizoguchi (Shinjuku Mizoguchi Clinic), speaking on “Improved brain function and nutrition”, discussed how low intake of glucose, amino acids, vitamins, and minerals leads to metabolic abnormalities in the brain and low production of neurotransmitters, which can cause depression and many other psychiatric illnesses not only in the elderly, but in middle age too. In “The brain prefers ketones to carbohydrates as an energy source”, Dr. Yoichi Ogushi (Department of Medical Informatics, Tokai University School of Medicine) presented data showing that a ketotic diet, also known as a low-carbohydrate diet (Atkins' or Bernstein's diet), is safe, and, moreover, that ketones are used as an energy source by the brain. This work suggested that advanced glycosylation end product is a risk factor for Alzheimer's and Perkinson's disease, and that glucose is only utilized after keton bodies by the brain. This notion in turn raises the possibility that a ketotic diet may prevent or slow the progression of Alzheimer's disease.Anti-Aging measures above mentioned may play crucial roles in preventing brain atrophy, cognitive impairment, and depression which are closely related to the aging process. Stable energy supply and adequate nutritional distribution to neurons in the brain are keys to maintain brain function through neuronal survival and biosynthesis of neurotransmitters.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"23 1","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91125585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical aromatherapy aimed at enhancing the prevention and symptomatic treatment of disease is widely used in nursing and the nursing field. It is important that the specific fragrance and its application are selected only after the absorption and mechanism of action of its essential oil are understood. Because it acts on the hippocampus and autonomic nervous system, fragrance stimulation has been considered a complementary and alternative medical therapy for dementia, sleeplessness and sleep disturbance, all of which are related to aging. The in vivo role of free radicals in the development of various diseases has recently been identified. A recent study reported that fragrance use enhanced the elimination of free radicals, and wide application of this modality in complementary and alternative medicine is expected.
{"title":"Aroma Therapy in Anti-Aging Medicine","authors":"K. Shibamoto, M. Mochizuki, M. Kusuhara","doi":"10.3793/JAAM.7.55","DOIUrl":"https://doi.org/10.3793/JAAM.7.55","url":null,"abstract":"Medical aromatherapy aimed at enhancing the prevention and symptomatic treatment of disease is widely used in nursing and the nursing field. It is important that the specific fragrance and its application are selected only after the absorption and mechanism of action of its essential oil are understood. Because it acts on the hippocampus and autonomic nervous system, fragrance stimulation has been considered a complementary and alternative medical therapy for dementia, sleeplessness and sleep disturbance, all of which are related to aging. The in vivo role of free radicals in the development of various diseases has recently been identified. A recent study reported that fragrance use enhanced the elimination of free radicals, and wide application of this modality in complementary and alternative medicine is expected.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"69 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78565812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Morishita, I. Komuro, M. Horiuchi, H. Nakagami, T. Minamino, Y. Higashi
“A man is as old as his arteries.” This statement was made by William Osler in 1898 and is still currently used by many researchers and clinicians as a witty remark. It constitutes a core concept of Anti-Aging. About 100 years has passed since he made this remark, and as we live in an age of plentiful food we now really understand how significant his statement is. The use of vascular age values calculated from measurement of vascular functions has gradually been increasing in routine medical examination and consultation. From now on, it will be increasingly important to link these data to practical strategies for the purpose of improving longevity coupled with health, i.e., for prevention of diseases and reduction of events related to ischemic diseases. For such linking, it is considered essential to accumulate both basic and clinical scientific evidence for vascular senescence. In this symposium, specialists in the concerned fields on both the basic and clinical sides have gathered to provide state-of-the-art knowledge under the theme of Anti-Aging Medicine in Cardiovascular Disease and regarding the question, “What is vascular senescence?”, conducting analyses of association with other diseases primarily involving blood vessels and the relationships between Anti-Aging measures, the renin-angiotensin system, and other relevant topics. We hope that the audience will pick up interesting findings that may be implemented in their daily research and acquire knowledge that will be helpful in their medical practices. Cognitive Function and Angiotensin Receptor Subtypes
{"title":"Anti-Aging Medicine in Cardiovascular Disease","authors":"R. Morishita, I. Komuro, M. Horiuchi, H. Nakagami, T. Minamino, Y. Higashi","doi":"10.3793/JAAM.7.45","DOIUrl":"https://doi.org/10.3793/JAAM.7.45","url":null,"abstract":"“A man is as old as his arteries.” This statement was made by William Osler in 1898 and is still currently used by many researchers and clinicians as a witty remark. It constitutes a core concept of Anti-Aging. About 100 years has passed since he made this remark, and as we live in an age of plentiful food we now really understand how significant his statement is. The use of vascular age values calculated from measurement of vascular functions has gradually been increasing in routine medical examination and consultation. From now on, it will be increasingly important to link these data to practical strategies for the purpose of improving longevity coupled with health, i.e., for prevention of diseases and reduction of events related to ischemic diseases. For such linking, it is considered essential to accumulate both basic and clinical scientific evidence for vascular senescence. In this symposium, specialists in the concerned fields on both the basic and clinical sides have gathered to provide state-of-the-art knowledge under the theme of Anti-Aging Medicine in Cardiovascular Disease and regarding the question, “What is vascular senescence?”, conducting analyses of association with other diseases primarily involving blood vessels and the relationships between Anti-Aging measures, the renin-angiotensin system, and other relevant topics. We hope that the audience will pick up interesting findings that may be implemented in their daily research and acquire knowledge that will be helpful in their medical practices. Cognitive Function and Angiotensin Receptor Subtypes","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"34 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90244006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Naito, Masaichi-chang-il Lee, Y. Kato, R. Nagai, Y. Yonei
Oxidative stress is a high-profile element among the risk factors for aging. Although several stress markers have been proposed for the evaluation of oxidative stress, there remains much room for improvement in testing and evaluation methods. In the Current Concept Session “Oxidative Stress Markers” at the of the most recent research works were presented under the titles “Present Status and New Development of Evaluation of Oxidative Stress Markers,” “Oxidative Modification of Proteins and Its Quantitative Detection,” and “Modification/Degeneration of Proteins and Advanced Glycation Endproducts (AGEs)”.Several markers are available for evaluation of the oxidative stress status. Methods of detecting oxidatively modified substances as new markers by mass spectrography (MS) have been developed. Oxidative modifications of highly reactive cysteine residues in several target proteins such as tyrosine phosphatase and thioredoxin-related proteins control the functions of relevant molecules, and thereby play an important role in signal transmission. Advanced glycation endproducts (AGEs) gradually accumulate with aging and are involved in the development of diabetic complications, Alzheimer's disease, and arteriosclerosis. Basic studies of the indicators of glycation are also important.This general article outlines oxidative stress markers with a focus on oxidative modification of proteins and glycation of proteins, both of which have received attention in recent years, and introduces information regarding newly discovered markers for oxidative stress.
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