Objectives: The link between changes in leg strength per body weight and metabolic syndrome was evaluated in Japanese men with a 1-year follow up.Subjects and Methods: We used data for 136 Japanese men (45.5 ± 8.5 years) with a 1-year follow up. All subjects were given instructions by well-trained medical staff on how to change their lifestyle. Metabolic syndrome has been defined by a new criterion in Japan. The association between changes in leg strength per body weight and metabolic syndrome was evaluated.Results: With a 1-year follow up, body weight, abdominal circumference, systolic blood pressure, diastolic blood pressure and triglyceride were significantly reduced. Leg strength and leg strength per body weight and HDL cholesterol were significantly increased. The prevalence of metabolic syndrome was significantly reduced. There was significant relationship between changes in metabolic syndrome and changes in leg strength per body weight. The prevalence of metabolic syndrome was significantly reduced in subjects with an increase in leg strength per body weight (Group I) compared to subjects without such an increase (Group D). In addition, there were remarkable differences in delta abdominal circumference (delta represents positive changes in parameters) between Group I and Group D.Conclusion: An increase in leg strength per body weight may be associated with improving metabolic syndrome and abdominal circumference in Japanese men.
{"title":"Increasing Leg Strength per Body Weight is Associated with Improvements in Metabolic Syndrome in Japanese Men","authors":"N. Miyatake, M. Miyachi, Takeyuki Numata","doi":"10.3793/JAAM.6.1","DOIUrl":"https://doi.org/10.3793/JAAM.6.1","url":null,"abstract":"Objectives: The link between changes in leg strength per body weight and metabolic syndrome was evaluated in Japanese men with a 1-year follow up.Subjects and Methods: We used data for 136 Japanese men (45.5 ± 8.5 years) with a 1-year follow up. All subjects were given instructions by well-trained medical staff on how to change their lifestyle. Metabolic syndrome has been defined by a new criterion in Japan. The association between changes in leg strength per body weight and metabolic syndrome was evaluated.Results: With a 1-year follow up, body weight, abdominal circumference, systolic blood pressure, diastolic blood pressure and triglyceride were significantly reduced. Leg strength and leg strength per body weight and HDL cholesterol were significantly increased. The prevalence of metabolic syndrome was significantly reduced. There was significant relationship between changes in metabolic syndrome and changes in leg strength per body weight. The prevalence of metabolic syndrome was significantly reduced in subjects with an increase in leg strength per body weight (Group I) compared to subjects without such an increase (Group D). In addition, there were remarkable differences in delta abdominal circumference (delta represents positive changes in parameters) between Group I and Group D.Conclusion: An increase in leg strength per body weight may be associated with improving metabolic syndrome and abdominal circumference in Japanese men.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"29 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82646192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Miyatake, M. Miyachi, I. Tabata, Takeyuki Numata
Objective: Both aerobic exercise level and body composition are associated with aging. In addition, lower aerobic exercise level and excess of body fat are risk for atherosclerosis. Therefore, the link between maximal oxygen uptake and anthropometric, body composition parameters was investigated.Subjects and Methods: We used data for 300 Japanese (150 men: 44.2±14.1 years, 150 women: 44.4±14.1 years) in a cross sectional analysis. Maximal oxygen uptake was measured by breath-by-breath method and body composition was evaluated by dual energy X-ray absorptiometry (DEXA).Results: Maximal oxygen uptake was significantly decreased with age over the age of 40. Body fat percentage measured by DEXA was significantly correlated with maximal oxygen uptake (men: r=−0.622, women: r=−0.604). In addition, the significant relationships between body fat percentage and clinical parameters i.e. triglyceride, high density lipoprotein (HDL) cholesterol, blood sugar, insulin and homeostasis model assessment (the HOMA index) were also noted.Conclusion: Lower maximal oxygen uptake may be characteristic in subjects with higher body fat percentage and aerobic exercise should be recommended for preventing lifestyle-related disease.
{"title":"Body Fat Percentage Measured by Dual Energy X-ray Absorptiometry is Associated with Maximal Oxygen Uptake in Japanese","authors":"N. Miyatake, M. Miyachi, I. Tabata, Takeyuki Numata","doi":"10.3793/JAAM.6.41","DOIUrl":"https://doi.org/10.3793/JAAM.6.41","url":null,"abstract":"Objective: Both aerobic exercise level and body composition are associated with aging. In addition, lower aerobic exercise level and excess of body fat are risk for atherosclerosis. Therefore, the link between maximal oxygen uptake and anthropometric, body composition parameters was investigated.Subjects and Methods: We used data for 300 Japanese (150 men: 44.2±14.1 years, 150 women: 44.4±14.1 years) in a cross sectional analysis. Maximal oxygen uptake was measured by breath-by-breath method and body composition was evaluated by dual energy X-ray absorptiometry (DEXA).Results: Maximal oxygen uptake was significantly decreased with age over the age of 40. Body fat percentage measured by DEXA was significantly correlated with maximal oxygen uptake (men: r=−0.622, women: r=−0.604). In addition, the significant relationships between body fat percentage and clinical parameters i.e. triglyceride, high density lipoprotein (HDL) cholesterol, blood sugar, insulin and homeostasis model assessment (the HOMA index) were also noted.Conclusion: Lower maximal oxygen uptake may be characteristic in subjects with higher body fat percentage and aerobic exercise should be recommended for preventing lifestyle-related disease.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"380 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76643723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Miyazaki, Tsutomu Hasegawa, N. Fujioka, M. Iwabayashi, K. Nomoto, H. Takahashi, U. Hamada, H. Ichikawa, K. Ishii, Y. Yonei
Objective: To-date, in middle-aged men the collection of data regarding the measurement of a wide range of health indicators, and the mutual relationships among these indicators, has been insufficient. Here, we evaluated from the viewpoint of anti-aging medicine, the effects on various anti-aging indicators in middle-aged men of a long-term intervention to prevent lifestyle-related diseases.Methods: Subjects were 18 male employees (mean age, 54.4 ± 7.4 years; mean body weight 77.5 ± 12.5 kg; mean BMI, 26.1 ± 3.6 kg/m2) of a machine manufacturer located in Kyoto City on whom a company-wide anti-aging medical checkup was performed. On the basis of the medical checkup results, exercise and nutritional instructions were given to the study subjects. In addition, subjects were lent pedometers and encouraged to walk, and the data recording the number of steps taken was collected once every four weeks. Anti-aging related indicators were measured before the study as well as 12 and 24 weeks thereafter. Muscle mass was measured with a body composition measuring device by bioelectrical impedance analysis (Physion MD), higher-brain functions were determined by the Wisconsin card sorting test (WCST), the degree of arteriosclerosis was evaluated by acceleration plethysmography (SDP-100), and bone mineral density was measured by ultrasonography (A-1000).(View PDF for the rest of the abstract.)
{"title":"Effects on Anti-Aging Indicators in Middle-Aged Men of An Intervention to Prevent Lifestyle-Related Diseases","authors":"R. Miyazaki, Tsutomu Hasegawa, N. Fujioka, M. Iwabayashi, K. Nomoto, H. Takahashi, U. Hamada, H. Ichikawa, K. Ishii, Y. Yonei","doi":"10.3793/JAAM.6.83","DOIUrl":"https://doi.org/10.3793/JAAM.6.83","url":null,"abstract":"Objective: To-date, in middle-aged men the collection of data regarding the measurement of a wide range of health indicators, and the mutual relationships among these indicators, has been insufficient. Here, we evaluated from the viewpoint of anti-aging medicine, the effects on various anti-aging indicators in middle-aged men of a long-term intervention to prevent lifestyle-related diseases.Methods: Subjects were 18 male employees (mean age, 54.4 ± 7.4 years; mean body weight 77.5 ± 12.5 kg; mean BMI, 26.1 ± 3.6 kg/m2) of a machine manufacturer located in Kyoto City on whom a company-wide anti-aging medical checkup was performed. On the basis of the medical checkup results, exercise and nutritional instructions were given to the study subjects. In addition, subjects were lent pedometers and encouraged to walk, and the data recording the number of steps taken was collected once every four weeks. Anti-aging related indicators were measured before the study as well as 12 and 24 weeks thereafter. Muscle mass was measured with a body composition measuring device by bioelectrical impedance analysis (Physion MD), higher-brain functions were determined by the Wisconsin card sorting test (WCST), the degree of arteriosclerosis was evaluated by acceleration plethysmography (SDP-100), and bone mineral density was measured by ultrasonography (A-1000).(View PDF for the rest of the abstract.)","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"124 1","pages":"83-94"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88733057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Miyatake, M. Miyachi, I. Tabata, Takeyuki Numata
Objective: The link between leg strength per body weight and oxygen uptake at ventilatory threshold (VT) was evaluated in Japanese women with a 1-year follow up.Subjects and Methods: We used data for 60 Japanese women (46.1 ± 10.6 years) with a 1-year follow up. Changes in leg strength per body weight on oxygen uptake at VT were also evaluated.Results: Oxygen uptake at VT (per body weight) was significantly correlated with body weight, body mass index (BMI), abdominal circumference, hip circumference, body fat percentage, leg strength and leg strength per body weight (r=0.520, p‹0.001). Body weight, BMI, abdominal circumference and body fat percentage were significantly reduced; work rate and right grip strength were significantly increased with a 1-year follow up. In addition, changes in oxygen uptake at VT (per body weight) were also significantly correlated with leg strength and leg strength per body weight (r=0.317, p=0.0137).Conclusion: An increase in leg strength per body weight may be associated with increasing oxygen uptake at VT in Japanese women.
目的:对日本女性进行为期1年的随访，评估每体重腿力量与呼吸阈值摄氧量之间的关系。研究对象和方法:研究对象为60名日本女性(46.1±10.6岁)，随访1年。还评估了VT时每体重腿力量对摄氧量的影响。结果:VT时摄氧量(单位体重)与体重、体重指数(BMI)、腹围、臀围、体脂率、腿力量、单位体重腿力量呈显著相关(r=0.520, p < 0.001)。体重、BMI、腹围、体脂率均显著降低;在1年的随访中，工作效率和右手握力显著增加。此外，VT时摄氧量(每体重)的变化也与腿力量和每体重腿力量呈显著相关(r=0.317, p=0.0137)。结论:日本女性VT时每体重腿力量的增加可能与摄氧量增加有关。
{"title":"Leg Strength per Body Weight is Associated with Ventilatory Threshold in Japanese Women","authors":"N. Miyatake, M. Miyachi, I. Tabata, Takeyuki Numata","doi":"10.3793/JAAM.6.5","DOIUrl":"https://doi.org/10.3793/JAAM.6.5","url":null,"abstract":"Objective: The link between leg strength per body weight and oxygen uptake at ventilatory threshold (VT) was evaluated in Japanese women with a 1-year follow up.Subjects and Methods: We used data for 60 Japanese women (46.1 ± 10.6 years) with a 1-year follow up. Changes in leg strength per body weight on oxygen uptake at VT were also evaluated.Results: Oxygen uptake at VT (per body weight) was significantly correlated with body weight, body mass index (BMI), abdominal circumference, hip circumference, body fat percentage, leg strength and leg strength per body weight (r=0.520, p‹0.001). Body weight, BMI, abdominal circumference and body fat percentage were significantly reduced; work rate and right grip strength were significantly increased with a 1-year follow up. In addition, changes in oxygen uptake at VT (per body weight) were also significantly correlated with leg strength and leg strength per body weight (r=0.317, p=0.0137).Conclusion: An increase in leg strength per body weight may be associated with increasing oxygen uptake at VT in Japanese women.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"8 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72591663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Mochizuki, Yoko Amenomori, R. Miyazaki, Tsutomu Hasegawa, Miwako Watanabe, Kazuhito Fukuike, Y. Yonei
Objective: Although the importance of exercise instruction in preventing metabolic syndrome and lifestyle-related diseases is evident, there exists little knowledge regarding specific types of exercise which is easily accepted by exercise beginners and provide strong motivation to continuing such exercise, and its expected effect. In the present open-label, comparative study, two types of exercise program were compared in exercise beginners.Methods: Twenty-three healthy premenopausal volunteer women aged between 35 (inclusive) and 45 (exclusive) years without experience of exercise were randomly allocated to Group M, which was prescribed a composite exercise program with muscle resistance training (n=12), or Group W, which was prescribed a simple exercise program with walking as a main component (n=11). The participants were instructed to perform their assigned exercise program for 40 minutes at a time, three times a week for 8 consecutive weeks at a fitness studio. After three withdrawals were excluded, 10 women (40.3 ± 1.9 years) in Group M and 10 (39.7 ± 2.7) in Group W were included in analyses of the following data obtained at baseline and after 8 weeks: examination for subjective symptoms (using the Anti-Aging QOL Common Questionnaire (AAQol), the State Trait Anxiety Inventory (SATI) for evaluation of anxiety, Young’s Symptom Distress Scale (SDS) for evaluation of depressed state, and the Kupperman Menopausal Index (KMI) for evaluation of symptoms of climacteric disturbance), physical examination, vascular function tests (cardio-ankle vascular index (CAVI), ankle brachial pressure index (ABI), and fingertip acceleration plethysmogram), blood tests (including but not limited to IGF-I and DHEA-s), oxidative stress tests (with a biological antioxidant potential (BAP) test and measurement of diacron-reactive oxygen metabolites (-ROMs), and skin image analysis.(View PDF for the rest of the abstract.)
{"title":"Evaluation of Exercise Programs at a Fitness Club in Female Exercise Beginners Using Anti-Aging Medical Indicators","authors":"T. Mochizuki, Yoko Amenomori, R. Miyazaki, Tsutomu Hasegawa, Miwako Watanabe, Kazuhito Fukuike, Y. Yonei","doi":"10.3793/JAAM.6.66","DOIUrl":"https://doi.org/10.3793/JAAM.6.66","url":null,"abstract":"Objective: Although the importance of exercise instruction in preventing metabolic syndrome and lifestyle-related diseases is evident, there exists little knowledge regarding specific types of exercise which is easily accepted by exercise beginners and provide strong motivation to continuing such exercise, and its expected effect. In the present open-label, comparative study, two types of exercise program were compared in exercise beginners.Methods: Twenty-three healthy premenopausal volunteer women aged between 35 (inclusive) and 45 (exclusive) years without experience of exercise were randomly allocated to Group M, which was prescribed a composite exercise program with muscle resistance training (n=12), or Group W, which was prescribed a simple exercise program with walking as a main component (n=11). The participants were instructed to perform their assigned exercise program for 40 minutes at a time, three times a week for 8 consecutive weeks at a fitness studio. After three withdrawals were excluded, 10 women (40.3 ± 1.9 years) in Group M and 10 (39.7 ± 2.7) in Group W were included in analyses of the following data obtained at baseline and after 8 weeks: examination for subjective symptoms (using the Anti-Aging QOL Common Questionnaire (AAQol), the State Trait Anxiety Inventory (SATI) for evaluation of anxiety, Young’s Symptom Distress Scale (SDS) for evaluation of depressed state, and the Kupperman Menopausal Index (KMI) for evaluation of symptoms of climacteric disturbance), physical examination, vascular function tests (cardio-ankle vascular index (CAVI), ankle brachial pressure index (ABI), and fingertip acceleration plethysmogram), blood tests (including but not limited to IGF-I and DHEA-s), oxidative stress tests (with a biological antioxidant potential (BAP) test and measurement of diacron-reactive oxygen metabolites (-ROMs), and skin image analysis.(View PDF for the rest of the abstract.)","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"43 1","pages":"66-78"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73781532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yonei, M. Iwabayashi, N. Fujioka, K. Nomoto, R. Miyazaki, S. Hibino, Yoko Takahashi, T. Mochizuki, H. Takahashi, U. Hamada, S. Mizuno, Shaw Watanabe, R. Takata, Reiko Yamamoto, T. Yanai
Objective: Vascular function testing and microarray analysis were performed to evaluate the physical effects of cassis (Ribes nigrum L.) juice in women.Methods: In healthy women (Study I: n=21, age 53.6±3.6 years, BMI 24.2±3.9; Study II: n=40, age 47.4±8.8 years, BMI 22.4±3.9) assigned to one of four cassis groups (polysaccharide (PS) content: 0, 50, 125, and 250 mg) or a water control group (duration of intake: 2 to 8 weeks), the following parameters were assessed: for vascular function, blood pressure, thermographically measured body surface temperature, CAVI (cardio-ankle vascular index), ABI (ankle-brachial pressure index), accelerated plethysmography, and FMD (flow-mediated dilation) were determined. In the PS 250 mg (n=3) and water (n=4) groups, total RNA was extracted from blood collected before and 2 weeks after the study to perform gene expression analysis using Human Whole Genome 4 × 44K kit (Agilent).Results: Cassis juice (PS content: 125 to 250 mg) (n=16) increased body fat percentage (+2.5%, p=0.011), decreased systolic (121.3±15.8 mmHg at baseline, −4.8%, p=0.001) and diastolic blood pressure (76.9±11.2 mmHg at baseline, −5.9%, p=0.001), and increased FMD blood flow (p=0.004), upper limb temperature (+0.23±0.47oC, p=0.011), and lower limb temperature (+0.55±0.50oC, p‹0.001). The percentage increase in lower limb temperature was dependent on PS (p‹0.05) and polyphenol (p‹0.01) contents. In gene analysis, inhibition of expression of α-adrenoceptor ADRA1D and thromboxane A2 receptor TBXA2R was prominent. Pathway analysis revealed significant accumulation of less frequently expressed genes (CACNA1B, GJB3, etc.) in the “Ca regulation in the cardiac cell” pathway (p=0.006). No serious adverse events occurred during the study.Conclusion: Cassis juice induced limb peripheral vasodilatation, increase in blood flow, and decrease in blood pressure. The microarray analysis showed inhibited expression of genes of α-adrenoceptor, thromboxane A2 receptor and Ca channel, and an inhibited pathway of Ca influx into vascular smooth muscle. Couppled with the fact that vascular endothelium plays a role in vasodilatation associated with various mRNA expressions, it is suggested that cassis juice may improve the function of endothelial cells.
{"title":"Evaluation of effects of cassis (Ribes nigrum L.) juice on human vascular function and gene expression using a microarray system","authors":"Y. Yonei, M. Iwabayashi, N. Fujioka, K. Nomoto, R. Miyazaki, S. Hibino, Yoko Takahashi, T. Mochizuki, H. Takahashi, U. Hamada, S. Mizuno, Shaw Watanabe, R. Takata, Reiko Yamamoto, T. Yanai","doi":"10.3793/JAAM.6.22","DOIUrl":"https://doi.org/10.3793/JAAM.6.22","url":null,"abstract":"Objective: Vascular function testing and microarray analysis were performed to evaluate the physical effects of cassis (Ribes nigrum L.) juice in women.Methods: In healthy women (Study I: n=21, age 53.6±3.6 years, BMI 24.2±3.9; Study II: n=40, age 47.4±8.8 years, BMI 22.4±3.9) assigned to one of four cassis groups (polysaccharide (PS) content: 0, 50, 125, and 250 mg) or a water control group (duration of intake: 2 to 8 weeks), the following parameters were assessed: for vascular function, blood pressure, thermographically measured body surface temperature, CAVI (cardio-ankle vascular index), ABI (ankle-brachial pressure index), accelerated plethysmography, and FMD (flow-mediated dilation) were determined. In the PS 250 mg (n=3) and water (n=4) groups, total RNA was extracted from blood collected before and 2 weeks after the study to perform gene expression analysis using Human Whole Genome 4 × 44K kit (Agilent).Results: Cassis juice (PS content: 125 to 250 mg) (n=16) increased body fat percentage (+2.5%, p=0.011), decreased systolic (121.3±15.8 mmHg at baseline, −4.8%, p=0.001) and diastolic blood pressure (76.9±11.2 mmHg at baseline, −5.9%, p=0.001), and increased FMD blood flow (p=0.004), upper limb temperature (+0.23±0.47oC, p=0.011), and lower limb temperature (+0.55±0.50oC, p‹0.001). The percentage increase in lower limb temperature was dependent on PS (p‹0.05) and polyphenol (p‹0.01) contents. In gene analysis, inhibition of expression of α-adrenoceptor ADRA1D and thromboxane A2 receptor TBXA2R was prominent. Pathway analysis revealed significant accumulation of less frequently expressed genes (CACNA1B, GJB3, etc.) in the “Ca regulation in the cardiac cell” pathway (p=0.006). No serious adverse events occurred during the study.Conclusion: Cassis juice induced limb peripheral vasodilatation, increase in blood flow, and decrease in blood pressure. The microarray analysis showed inhibited expression of genes of α-adrenoceptor, thromboxane A2 receptor and Ca channel, and an inhibited pathway of Ca influx into vascular smooth muscle. Couppled with the fact that vascular endothelium plays a role in vasodilatation associated with various mRNA expressions, it is suggested that cassis juice may improve the function of endothelial cells.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"28 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81245136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Urano, M. Shiraki, Ryonosuke Yamaga, Noriko Sasaki, Y. Ouchi, S. Inoue
Background: Adiponectin is a circulating peptide present in adipose tissue. It mediates its insulin-sensitizing and anti-atherogenic effects on target tissues via 2 receptors—adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). Recent studies have reported that ADIPOR1 deficiency in mice results in increased body weight and obesity. In the present study, we examined the association between a single nucleotide polymorphism (SNP) in the 5´ flanking region of the ADIPOR1 gene and body mass index (BMI) in the Japanese population.Methods: Association of an SNP (rs4989513) with the BMI was examined in 774 postmenopausal Japanese women.Results: Rs4989513 SNP was significantly associated with the BMI (P = 0.0412).Conclusion: Genetic variation at the ADIPOR1 gene locus is associated with BMI, suggesting that the ADIPOR1 gene is involved in the development of obesity.
{"title":"Association of a Sequence Variation in the Gene Encoding Adiponectin Receptor 1 (ADIPOR1) with Body Mass Index in the Japanese Population","authors":"T. Urano, M. Shiraki, Ryonosuke Yamaga, Noriko Sasaki, Y. Ouchi, S. Inoue","doi":"10.3793/JAAM.6.79","DOIUrl":"https://doi.org/10.3793/JAAM.6.79","url":null,"abstract":"Background: Adiponectin is a circulating peptide present in adipose tissue. It mediates its insulin-sensitizing and anti-atherogenic effects on target tissues via 2 receptors—adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). Recent studies have reported that ADIPOR1 deficiency in mice results in increased body weight and obesity. In the present study, we examined the association between a single nucleotide polymorphism (SNP) in the 5´ flanking region of the ADIPOR1 gene and body mass index (BMI) in the Japanese population.Methods: Association of an SNP (rs4989513) with the BMI was examined in 774 postmenopausal Japanese women.Results: Rs4989513 SNP was significantly associated with the BMI (P = 0.0412).Conclusion: Genetic variation at the ADIPOR1 gene locus is associated with BMI, suggesting that the ADIPOR1 gene is involved in the development of obesity.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"94 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91017589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Fukami, Hideki Tachimoto, M. Kishi, T. Kage, Yasukazu Tanaka, Y. Koga, T. Shirasawa
Acetic acid bacteria, the fermentative microorganisms of traditional foods, have unique and highly pure membrane lipid components such as sphingolipids (dihydroceramide). Sphingolipids are important components of brain tissue and many indirect studies demonstrated that ingestion of ceramide or its sphingolipid-derivatives might have beneficial effects on cognitive function. In a double-blind experiment, we tested whether continuous ingestion of the acetic acid bacterium, Acetobacter malorum NCI 1683 (S24) derived from fermented milk, could improve cognitive function in healthy middle-aged and elderly persons. Cognitive function was evaluated using the CogHealth battery of tasks that can detect slight variations. A 12-week supplement of Acetobacter malorum significantly shortened the response times of the working memory, the primary outcome of this study, compared to the placebo supplement (P‹0.05). The working memory and delayed recall tasks in the low-dosage group (111 mg/day), and the choice reaction and delayed recall tasks in the high-dosage group (400 mg/day) were also improved at 8 or 12 weeks when compared to those observed before treatment (P‹0.05). These results suggest that the continuous ingestion of Acetobacter malorum has a beneficial effect on cognitive function. No clinical problems were observed in the physical and medical examinations of any of the groups. These results and the historic experiences with eating fermented foods indicate that an intake of acetic acid bacteria is safe and beneficial for the life of elderly persons through the maintenance of cognitive function from the early stages of aging.
{"title":"Continuous Ingestion of Acetic Acid Bacteria:Effect on Cognitive Function in Healthy Middle-Aged and Elderly Persons","authors":"H. Fukami, Hideki Tachimoto, M. Kishi, T. Kage, Yasukazu Tanaka, Y. Koga, T. Shirasawa","doi":"10.3793/JAAM.6.60","DOIUrl":"https://doi.org/10.3793/JAAM.6.60","url":null,"abstract":"Acetic acid bacteria, the fermentative microorganisms of traditional foods, have unique and highly pure membrane lipid components such as sphingolipids (dihydroceramide). Sphingolipids are important components of brain tissue and many indirect studies demonstrated that ingestion of ceramide or its sphingolipid-derivatives might have beneficial effects on cognitive function. In a double-blind experiment, we tested whether continuous ingestion of the acetic acid bacterium, Acetobacter malorum NCI 1683 (S24) derived from fermented milk, could improve cognitive function in healthy middle-aged and elderly persons. Cognitive function was evaluated using the CogHealth battery of tasks that can detect slight variations. A 12-week supplement of Acetobacter malorum significantly shortened the response times of the working memory, the primary outcome of this study, compared to the placebo supplement (P‹0.05). The working memory and delayed recall tasks in the low-dosage group (111 mg/day), and the choice reaction and delayed recall tasks in the high-dosage group (400 mg/day) were also improved at 8 or 12 weeks when compared to those observed before treatment (P‹0.05). These results suggest that the continuous ingestion of Acetobacter malorum has a beneficial effect on cognitive function. No clinical problems were observed in the physical and medical examinations of any of the groups. These results and the historic experiences with eating fermented foods indicate that an intake of acetic acid bacteria is safe and beneficial for the life of elderly persons through the maintenance of cognitive function from the early stages of aging.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"9 1","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88853098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Iwabayashi, N. Fujioka, K. Nomoto, R. Miyazaki, H. Takahashi, S. Hibino, Yoko Takahashi, K. Nishikawa, Mitsunori Nishida, Y. Yonei
Objective: An open-label noncontrolled study was conducted in subjects with increased oxidative stress burden to evaluate the mental and physical effects of antioxidant astaxanthin.Methods: Of 35 healthy postmenopausal women, 21 with high oxidative stress (diacron-reactive oxygen metabolites; d-ROM) were selected, and 20 (55.7±4.8 years old, BMI 22.1±3.9) were included in the study, after excluding 1 dropout. In subjects orally treated with astaxanthin (Fuji Chemical Industry) at a daily dose of 12 mg for eight weeks, Anti-Aging QOL Common Questionnaire, somatometry, hematological examination/urinalysis, oxidative stress test, and vascular function tests (cardio ankle vascular index, CAVI; ankle brachial pressure index, ABI; fingertip acceleration pulse wave; flow-mediated dilation FMD) were performed before and four and eight weeks after the start of the study.Results: After eight-week treatment with astaxanthin, significant improvement was observed in 5 of 34 physical symptoms listed in the common questionnaire, including “tired eyes”, “stiff shoulders”, “constipation”, “gray hair”, and “cold skin”, and in 3 of 21 mental symptoms, including “daily life is not enjoyable”, “difficulty in falling asleep”, and “a sense of tension”. In addition, systolic (118.0±16.4 mmHg at baseline, −4.6%, p=0.021) and diastolic blood pressure (74.1±11.7 mmHg at baseline, −6.9%, p‹0.001) significantly decreased. In the vascular function test, CAVI, fingertip acceleration pulse wave, and FMD did not change, but ABI significantly increased from 1.06±0.10 at baseline to 1.10±0.06 at Week 8 (+3.7%, p=0.030). In the oxidative stress test, d-ROM did not change, but BAP significantly increased (+4.6%, p=0.030). In biochemical examination, AST (−19.2%, p=0.044), LDH (−6.4%, p=0.006), and HbA1c (−3.2%, p‹0.001) significantly improved. Although IGF-I and insulin did not change, DHEA-s (−15.1%, p‹0.001), cortisol (−22.8%, p=0.002), and adiponectin (−14.1%, p=0.003) decreased. No serious adverse event occurred during or after the study.Conclusion: Results show that astaxanthin may enhance antioxidant capacity (increase BAP), reduce lower limb vascular resistance (increase ABI), decrease blood pressure, and improve physical symptoms in women with high oxidative stress.
{"title":"Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden","authors":"M. Iwabayashi, N. Fujioka, K. Nomoto, R. Miyazaki, H. Takahashi, S. Hibino, Yoko Takahashi, K. Nishikawa, Mitsunori Nishida, Y. Yonei","doi":"10.3793/JAAM.6.15","DOIUrl":"https://doi.org/10.3793/JAAM.6.15","url":null,"abstract":"Objective: An open-label noncontrolled study was conducted in subjects with increased oxidative stress burden to evaluate the mental and physical effects of antioxidant astaxanthin.Methods: Of 35 healthy postmenopausal women, 21 with high oxidative stress (diacron-reactive oxygen metabolites; d-ROM) were selected, and 20 (55.7±4.8 years old, BMI 22.1±3.9) were included in the study, after excluding 1 dropout. In subjects orally treated with astaxanthin (Fuji Chemical Industry) at a daily dose of 12 mg for eight weeks, Anti-Aging QOL Common Questionnaire, somatometry, hematological examination/urinalysis, oxidative stress test, and vascular function tests (cardio ankle vascular index, CAVI; ankle brachial pressure index, ABI; fingertip acceleration pulse wave; flow-mediated dilation FMD) were performed before and four and eight weeks after the start of the study.Results: After eight-week treatment with astaxanthin, significant improvement was observed in 5 of 34 physical symptoms listed in the common questionnaire, including “tired eyes”, “stiff shoulders”, “constipation”, “gray hair”, and “cold skin”, and in 3 of 21 mental symptoms, including “daily life is not enjoyable”, “difficulty in falling asleep”, and “a sense of tension”. In addition, systolic (118.0±16.4 mmHg at baseline, −4.6%, p=0.021) and diastolic blood pressure (74.1±11.7 mmHg at baseline, −6.9%, p‹0.001) significantly decreased. In the vascular function test, CAVI, fingertip acceleration pulse wave, and FMD did not change, but ABI significantly increased from 1.06±0.10 at baseline to 1.10±0.06 at Week 8 (+3.7%, p=0.030). In the oxidative stress test, d-ROM did not change, but BAP significantly increased (+4.6%, p=0.030). In biochemical examination, AST (−19.2%, p=0.044), LDH (−6.4%, p=0.006), and HbA1c (−3.2%, p‹0.001) significantly improved. Although IGF-I and insulin did not change, DHEA-s (−15.1%, p‹0.001), cortisol (−22.8%, p=0.002), and adiponectin (−14.1%, p=0.003) decreased. No serious adverse event occurred during or after the study.Conclusion: Results show that astaxanthin may enhance antioxidant capacity (increase BAP), reduce lower limb vascular resistance (increase ABI), decrease blood pressure, and improve physical symptoms in women with high oxidative stress.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"66 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76528636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Fujioka, S. Hibino, Ayako Wakahara, Takahiro Kawagishi, Kyoko Taku, S. Mizuno, Shaw Watanabe, H. Takahashi, U. Hamada, Yoko Takahashi, Y. Yonei
109 Objective: To elucidate the effects of sea salt and various other soap ingredients on skin in humans. Methods: Forty healthy women (age 30.4 ± 6.0 years) were assigned to one of four test-soap groups (sea salt, SS; collagen added, SS+C; humic added, SS+H; or, fucoidan added, SS+F) or a control group. Subjects washed their face with the soap twice daily for eight weeks. Before and after the study, subjects undertook the Anti-Aging QOL Common Questionnaire (AAQol), skin image analysis (VISIAII), elasticity tests by a Cutometer (MPA580), and moisture tests by a Corneometer (CM825). Results: At 8 weeks, significant improvements were seen in symptoms scores for “noticeable blackheads in pores” and “oily face” in the SS group, the score for “concerned about spots or freckles” in the SS+H group, and the scores for “noticeable pores”, “concerned about pore opening”, “dry skin”, “rough skin”, “concerned about rough skin”, and “corner of eyes sagging” in the SS+F group. There was no significant change in skin moisture. Compared to controls, the R2 index of skin elasticity showed improvement in the SS+C group by inter-group analysis (p=0.009). On skin image analysis, the number of face wrinkles bilaterally (– 26.6%, p=0.008) in the SS+F group and the number of wrinkles on the right side of the face (– 45.5%, p＝0.005) in the SS group) showed significant improvement. Although an increase in ultraviolet (UV) spots was seen in the SS and control groups, this increase was significantly attenuated in the SS+C group (inter-group analysis: p<0.05). Further, compared to controls, there was a significant reduction in the number of red spots in the SS+H group (number：– 7.9%, p＝0.022, % area：– 11.7%, p=0.039). No severe adverse effects were observed during this study. Conclusion: An improvement in wrinkles was seen in the SS group, with different additional elements displaying benefits in different areas of skin appearance and health. The SS+C group showed beneficial results with regard to elasticity and UV spots, the SS+H group showed beneficial results in red spots, and the SS+F group showed beneficial results in moisture levels and wrinkles.
{"title":"Effects of Various Soap Elements on Skin","authors":"N. Fujioka, S. Hibino, Ayako Wakahara, Takahiro Kawagishi, Kyoko Taku, S. Mizuno, Shaw Watanabe, H. Takahashi, U. Hamada, Yoko Takahashi, Y. Yonei","doi":"10.3793/JAAM.6.109","DOIUrl":"https://doi.org/10.3793/JAAM.6.109","url":null,"abstract":"109 Objective: To elucidate the effects of sea salt and various other soap ingredients on skin in humans. Methods: Forty healthy women (age 30.4 ± 6.0 years) were assigned to one of four test-soap groups (sea salt, SS; collagen added, SS+C; humic added, SS+H; or, fucoidan added, SS+F) or a control group. Subjects washed their face with the soap twice daily for eight weeks. Before and after the study, subjects undertook the Anti-Aging QOL Common Questionnaire (AAQol), skin image analysis (VISIAII), elasticity tests by a Cutometer (MPA580), and moisture tests by a Corneometer (CM825). Results: At 8 weeks, significant improvements were seen in symptoms scores for “noticeable blackheads in pores” and “oily face” in the SS group, the score for “concerned about spots or freckles” in the SS+H group, and the scores for “noticeable pores”, “concerned about pore opening”, “dry skin”, “rough skin”, “concerned about rough skin”, and “corner of eyes sagging” in the SS+F group. There was no significant change in skin moisture. Compared to controls, the R2 index of skin elasticity showed improvement in the SS+C group by inter-group analysis (p=0.009). On skin image analysis, the number of face wrinkles bilaterally (– 26.6%, p=0.008) in the SS+F group and the number of wrinkles on the right side of the face (– 45.5%, p＝0.005) in the SS group) showed significant improvement. Although an increase in ultraviolet (UV) spots was seen in the SS and control groups, this increase was significantly attenuated in the SS+C group (inter-group analysis: p<0.05). Further, compared to controls, there was a significant reduction in the number of red spots in the SS+H group (number：– 7.9%, p＝0.022, % area：– 11.7%, p=0.039). No severe adverse effects were observed during this study. Conclusion: An improvement in wrinkles was seen in the SS group, with different additional elements displaying benefits in different areas of skin appearance and health. The SS+C group showed beneficial results with regard to elasticity and UV spots, the SS+H group showed beneficial results in red spots, and the SS+F group showed beneficial results in moisture levels and wrinkles.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"47 1","pages":"109-118"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78200737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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