K. Nomoto, R. Miyazaki, Tsutomu Hasegawa, U. Hamada, H. Ichikawa, Y. Yonei
Objective: We developed an easily maintained health promotion program for factory workers in a company which introduced an anti-aging medical checkup with pedometer-based walking management. Here, we describe it's effect on body and mind.Methods: Subjects were 17 male employees (mean age, 50.6±4.3 years old; mean body weight 82.8±9.2kg; mean BMI, 27.2±1.9kg/m2: mean abdominal circumference; 95.6±5.7cm) of a machine factory (Murata Machinery, Inuyama-city, Aichi) who were judged to require lifestyle guidance. They were provided with pedometers and encouraged to walk. Data records for the number of steps taken were collected every four weeks. An anti-aging medical checkup was conducted three times before, 12 weeks and 24 weeks after the study.Results: Collection ratio for information on the number of steps walked was 82.8%. The average daily number of steps walked increased from a baseline of 10277 steps by 1096 steps (10.7%) at 24 weeks. Anthropometry showed significant improvements in weight (−3.9%, p=0.013) BMI (−3.6%, p=0.014) and abdominal circumference (−4.8%, p=0.003). Clinical laboratory tests showed significant improvements in HDL cholesterol (pre-value 51.0±10.0mg/dl, 12.7%, p=0.043), HbA1c (pre-value 5.5±0.6%, −8.4%, p‹0.001) and adiponectin (pre-value 5.17±1.03μg/ml, 39.9%, p=0.001). Anti-aging medical checkup showed the highest functional age, 35.3% in nerves, 35.3% in bone, and 29.4% in blood vessels, as well as significant changes in vascular age by acceleration plethysmography SDP-100 (pre-value 52.1±12.0 years old, −12.7%, p=0.024), calcaneus bone stiffness by ultrasonography A-1000 (9.5%, p=0.007), and response time by the Wisconsin card sorting test (p=0.024). No significant change was noted in muscle age as evaluated by bioelectrical impedance analysis (Physion MD). The questionnaire showed that the major reason for continuation with the program was “the presence of an anti-aging medical checkup”, health promotion was assisted by “results of anti-aging medical checkup”, and the modified behavior was “increased amount of exercise”.Conclusion: This health promotion program, consisting of an anti-aging medical checkup and pedometer-guided walking program, appears effective in improving the lifestyle and condition of factory workers.
{"title":"Efficacy of a Health Promotion Program with Anti-Aging Medical Checkup and Instructions for Walking under Pedometer Management in Factory Workers","authors":"K. Nomoto, R. Miyazaki, Tsutomu Hasegawa, U. Hamada, H. Ichikawa, Y. Yonei","doi":"10.3793/JAAM.7.73","DOIUrl":"https://doi.org/10.3793/JAAM.7.73","url":null,"abstract":"Objective: We developed an easily maintained health promotion program for factory workers in a company which introduced an anti-aging medical checkup with pedometer-based walking management. Here, we describe it's effect on body and mind.Methods: Subjects were 17 male employees (mean age, 50.6±4.3 years old; mean body weight 82.8±9.2kg; mean BMI, 27.2±1.9kg/m2: mean abdominal circumference; 95.6±5.7cm) of a machine factory (Murata Machinery, Inuyama-city, Aichi) who were judged to require lifestyle guidance. They were provided with pedometers and encouraged to walk. Data records for the number of steps taken were collected every four weeks. An anti-aging medical checkup was conducted three times before, 12 weeks and 24 weeks after the study.Results: Collection ratio for information on the number of steps walked was 82.8%. The average daily number of steps walked increased from a baseline of 10277 steps by 1096 steps (10.7%) at 24 weeks. Anthropometry showed significant improvements in weight (−3.9%, p=0.013) BMI (−3.6%, p=0.014) and abdominal circumference (−4.8%, p=0.003). Clinical laboratory tests showed significant improvements in HDL cholesterol (pre-value 51.0±10.0mg/dl, 12.7%, p=0.043), HbA1c (pre-value 5.5±0.6%, −8.4%, p‹0.001) and adiponectin (pre-value 5.17±1.03μg/ml, 39.9%, p=0.001). Anti-aging medical checkup showed the highest functional age, 35.3% in nerves, 35.3% in bone, and 29.4% in blood vessels, as well as significant changes in vascular age by acceleration plethysmography SDP-100 (pre-value 52.1±12.0 years old, −12.7%, p=0.024), calcaneus bone stiffness by ultrasonography A-1000 (9.5%, p=0.007), and response time by the Wisconsin card sorting test (p=0.024). No significant change was noted in muscle age as evaluated by bioelectrical impedance analysis (Physion MD). The questionnaire showed that the major reason for continuation with the program was “the presence of an anti-aging medical checkup”, health promotion was assisted by “results of anti-aging medical checkup”, and the modified behavior was “increased amount of exercise”.Conclusion: This health promotion program, consisting of an anti-aging medical checkup and pedometer-guided walking program, appears effective in improving the lifestyle and condition of factory workers.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"116 1","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77268239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Nagai, Takefumi Mori, Yasuhiko Yamamoto, Y. Kaji, Y. Yonei
Carbohydrates are indispensable nutrients for life. However, due to the presence of a carbonyl group, reducing sugars such as glucose react non-enzymatically with amino groups on proteins in glycation (or Maillard) reactions. This reaction is divided into early and advanced phase reactions: the former covers the reaction progression up to the Amadori rearrangement, and the latter covers the reaction through the subsequent alterations of oxidation, dehydration, condensation, and so on, eventually generating advanced glycation end products (AGEs). Among post-translational modifications, processes such as phosphorylation or acetylation are known as “post-translational modifications with order,” because the target proteins and the time of modification are controlled. However, glycation is a “post-translational modification with disorder” because post-translational modification of proteins by glucose progresses non-enzymatically, irreversibly, and at random, and because the progression depends on the existing time (aging) and the concentration of glucose, rather than the variety of proteins involved. While AGEs were initially considered simply as rust or waste matter in the body, significant attention is now afforded these compounds as a target molecule for newly-developing drugs, for the following reasons: AGEs damage the body by changing the structure and affecting the function proteins; receptors that recognizes AGEs, such as RAGE (receptor for AGE), exist in the body and mediate cellular derangements to induce morbidity; and inhibitors for AGE generation, such as aminoguanidine, pyridoxamine, and benfotiamine, delay the pathogenesis of diabetic nephropathy and retinopathy. Further, racemization proteins containing D-amino acids have been noted, along with AGEs, in drusen, which are characteristic of age-related macular degeneration (AMD). Here, we introduce current topics and future goals of AGEs research, particularly with regard to kidney disease associated with aging and diabetes mellitus, and touch on the involvement of AGEs in the progression of ocular diseases and the function of RAGE.
{"title":"Significance of Advanced Glycation End Products in Aging-Related Disease","authors":"R. Nagai, Takefumi Mori, Yasuhiko Yamamoto, Y. Kaji, Y. Yonei","doi":"10.3793/JAAM.7.112","DOIUrl":"https://doi.org/10.3793/JAAM.7.112","url":null,"abstract":"Carbohydrates are indispensable nutrients for life. However, due to the presence of a carbonyl group, reducing sugars such as glucose react non-enzymatically with amino groups on proteins in glycation (or Maillard) reactions. This reaction is divided into early and advanced phase reactions: the former covers the reaction progression up to the Amadori rearrangement, and the latter covers the reaction through the subsequent alterations of oxidation, dehydration, condensation, and so on, eventually generating advanced glycation end products (AGEs). Among post-translational modifications, processes such as phosphorylation or acetylation are known as “post-translational modifications with order,” because the target proteins and the time of modification are controlled. However, glycation is a “post-translational modification with disorder” because post-translational modification of proteins by glucose progresses non-enzymatically, irreversibly, and at random, and because the progression depends on the existing time (aging) and the concentration of glucose, rather than the variety of proteins involved. While AGEs were initially considered simply as rust or waste matter in the body, significant attention is now afforded these compounds as a target molecule for newly-developing drugs, for the following reasons: AGEs damage the body by changing the structure and affecting the function proteins; receptors that recognizes AGEs, such as RAGE (receptor for AGE), exist in the body and mediate cellular derangements to induce morbidity; and inhibitors for AGE generation, such as aminoguanidine, pyridoxamine, and benfotiamine, delay the pathogenesis of diabetic nephropathy and retinopathy. Further, racemization proteins containing D-amino acids have been noted, along with AGEs, in drusen, which are characteristic of age-related macular degeneration (AMD). Here, we introduce current topics and future goals of AGEs research, particularly with regard to kidney disease associated with aging and diabetes mellitus, and touch on the involvement of AGEs in the progression of ocular diseases and the function of RAGE.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"107 1","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81185111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hibino, U. Hamada, H. Takahashi, Miwako Watanabe, N. Nozato, Y. Yonei
Objective: Brewer’s yeast contains vitamins, minerals, amino acids and other nutrients, and has been reported to control intestinal function as well as to exert anti-ulceration, anti-tumor and anti-allergy effects. The present study evaluated the effects of oral treatment with dried brewer’s yeast tablets (study product) on skin in a single-blind placebo-controlled design in humans.Methods: Thirty-two healthy volunteer women (37.0±4.8 years) were allocated as follows: Group E-30 (n=11) were treated with 30 tablets/day of the study product (containing 7,125mg/day of dried brewer’s yeast), Group E-9 (n=10) were given 9 tablets/day of the study product, and the control group (n=11) were given 30 placebo tablets/day. The treatment period was 8 weeks. Two patients prematurely discontinued the study (discontinuation rate: 5.9%) and were excluded from the analyses. The study product (Ebios Tablet®) was provided by Asahi Food & Healthcare Co., Ltd. Before and at 4 and 8 weeks after the study, subjective symptoms were evaluated using the Anti-Aging QOL Common Questionnaire (AAQol) and checking skin symptoms, skin images were analyzed with SK Info (SKI, Integral Co.) and Aphrodite-III (PSI), and skin color (CM-700d, Konica Minolta Sensing, Inc.) and elasticity (Cutometer MPA580, Courage & Khazaka electronic GmbH) were measured.Results: In Group E-30, the AAQol physical symptom “cold skin” score was significantly improved at 8 weeks (p‹0.05). The skin symptoms “make-up runs easily” and “desiccated and gritty skin,” as well as the physical symptom “menstruation-related troubles” were improved in a significant and dose-dependent way from the control group (p‹0.01). On skin analysis, SKI demonstrated an increase in moisture content (15.4%, p=0.010), decrease in erythema (−18.3%, p‹0.001) and increase in elasticity (13.3%, p=0.003), while PSI revealed an increase in hydration (Total: 14.5%, T zone: 13.7%, U zone: 18.2%, p‹0.01) and decrease in pores (− 32.7%, p=0.022). Cutometer analysis showed a dose-dependent increase in skin elasticity, while analysis of skin color showed a decrease in hemoglobin (−9.5%, p=0.016), improved lightness (− 0.7%, p=0.045) and decrease in redness (−8.3%, p=0.013). During the study period, no serious adverse events were noted.Conclusion: These results suggest that treatment with dried brewer’s yeast is useful in improving skin condition, e.g. moisture content and elasticity, and also QOL.
{"title":"Effects of Dried Brewer’s Yeast on Skin and QOL","authors":"S. Hibino, U. Hamada, H. Takahashi, Miwako Watanabe, N. Nozato, Y. Yonei","doi":"10.3793/JAAM.7.18","DOIUrl":"https://doi.org/10.3793/JAAM.7.18","url":null,"abstract":"Objective: Brewer’s yeast contains vitamins, minerals, amino acids and other nutrients, and has been reported to control intestinal function as well as to exert anti-ulceration, anti-tumor and anti-allergy effects. The present study evaluated the effects of oral treatment with dried brewer’s yeast tablets (study product) on skin in a single-blind placebo-controlled design in humans.Methods: Thirty-two healthy volunteer women (37.0±4.8 years) were allocated as follows: Group E-30 (n=11) were treated with 30 tablets/day of the study product (containing 7,125mg/day of dried brewer’s yeast), Group E-9 (n=10) were given 9 tablets/day of the study product, and the control group (n=11) were given 30 placebo tablets/day. The treatment period was 8 weeks. Two patients prematurely discontinued the study (discontinuation rate: 5.9%) and were excluded from the analyses. The study product (Ebios Tablet®) was provided by Asahi Food & Healthcare Co., Ltd. Before and at 4 and 8 weeks after the study, subjective symptoms were evaluated using the Anti-Aging QOL Common Questionnaire (AAQol) and checking skin symptoms, skin images were analyzed with SK Info (SKI, Integral Co.) and Aphrodite-III (PSI), and skin color (CM-700d, Konica Minolta Sensing, Inc.) and elasticity (Cutometer MPA580, Courage & Khazaka electronic GmbH) were measured.Results: In Group E-30, the AAQol physical symptom “cold skin” score was significantly improved at 8 weeks (p‹0.05). The skin symptoms “make-up runs easily” and “desiccated and gritty skin,” as well as the physical symptom “menstruation-related troubles” were improved in a significant and dose-dependent way from the control group (p‹0.01). On skin analysis, SKI demonstrated an increase in moisture content (15.4%, p=0.010), decrease in erythema (−18.3%, p‹0.001) and increase in elasticity (13.3%, p=0.003), while PSI revealed an increase in hydration (Total: 14.5%, T zone: 13.7%, U zone: 18.2%, p‹0.01) and decrease in pores (− 32.7%, p=0.022). Cutometer analysis showed a dose-dependent increase in skin elasticity, while analysis of skin color showed a decrease in hemoglobin (−9.5%, p=0.016), improved lightness (− 0.7%, p=0.045) and decrease in redness (−8.3%, p=0.013). During the study period, no serious adverse events were noted.Conclusion: These results suggest that treatment with dried brewer’s yeast is useful in improving skin condition, e.g. moisture content and elasticity, and also QOL.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"32 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81125080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kusuhara, K. Urakami, Vincent Zangiacomi, K. Hoshino
66 Following vision, the sense of smell and odor are important sources of external information. However, smell is not acknowledged as an important sensory faculty in clinical medicine and olfaction functions have not been sufficiently examined. Moreover, odor is not used in most diagnoses. Elements of the cause of the change in body odor with aging, i.e. aging odors, have been identified. Although it is considered that diseases are characterized by specific odors, particularly cancer, a characteristic known as byoshu in Japan, the fundamental nature of byoshu has not been clarified. Recently, with developments in techniques for the analysis of odor and greater understanding of the molecular mechanism of the sense of smell, it has become possible to analyze the odor elements that cause byoshu. Moreover, the ability to use odor elements and volatile organic compounds to diagnose cancer has also been demonstrated. Development of convenient methods of odor analysis will allow the bedside or outpatient diagnosis of various diseases, including cancer. Abstract Masatoshi Kusuhara 1), Kenichi Urakami 1), Vincent Zangiacomi 1), Kunihide Hoshino 2)
{"title":"Disease and Smell: \"Byoshu\"","authors":"M. Kusuhara, K. Urakami, Vincent Zangiacomi, K. Hoshino","doi":"10.3793/JAAM.7.66","DOIUrl":"https://doi.org/10.3793/JAAM.7.66","url":null,"abstract":"66 Following vision, the sense of smell and odor are important sources of external information. However, smell is not acknowledged as an important sensory faculty in clinical medicine and olfaction functions have not been sufficiently examined. Moreover, odor is not used in most diagnoses. Elements of the cause of the change in body odor with aging, i.e. aging odors, have been identified. Although it is considered that diseases are characterized by specific odors, particularly cancer, a characteristic known as byoshu in Japan, the fundamental nature of byoshu has not been clarified. Recently, with developments in techniques for the analysis of odor and greater understanding of the molecular mechanism of the sense of smell, it has become possible to analyze the odor elements that cause byoshu. Moreover, the ability to use odor elements and volatile organic compounds to diagnose cancer has also been demonstrated. Development of convenient methods of odor analysis will allow the bedside or outpatient diagnosis of various diseases, including cancer. Abstract Masatoshi Kusuhara 1), Kenichi Urakami 1), Vincent Zangiacomi 1), Kunihide Hoshino 2)","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"108 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90561625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
161 Cardiovascular Diseases (CVD) and Alimentary Comparison Study was a WHO-coordinated multi-center epidemiological survey on diets and CVD risks and mortalities in 61 populations. Twenty-four-hour urinary (24U) taurine (T) was inversely related significantly with coronary heart disease mortality. Higher 24U-T excreters over the mean had significantly lower body mass index (BMI), diastolic and systolic BP (SBP, DBP), and total cholesterol (T-Cho), than lower T excreters below the mean. Higher 24-U-magnesium (M) excreters over the mean had significantly lower BMI, SBP, DBP, and T-Cho. Therefore, higher T and M excreters over the means had significantly lower BMI, SBP, DBP and T-Cho than lower T and M excreters below the means. Australian aboriginals before the mid-18th century lived hunters’ and food gathers’ life, eating seafood and nuts rich in T and M so that they were supposed to be free from metabolic syndrome (MS). However, aboriginals living in urban Melbourne had nearly the highest prevalence of MS in 61populations and therefore, aboriginals were invited to an intervention study to take 25g of soy protein daily from breads for 8 weeks. Their CVD risks were significantly decreased, indicating traditional oriental soy diets containing soy protein, isoflavones and M could prevent CDV. Since the evolutional origin of human life was traced back to in the sea containing abundant M and food gatherers lived on seafood and bush food rich in T and M, T and M are assumed to be essential for cardiovascular health thus for healthy longevity. Abstract Yukio Yamori and Mari Mori
161例心血管疾病(CVD)和食物比较研究是世卫组织协调的一项针对61个人群的饮食与CVD风险和死亡率的多中心流行病学调查。24小时尿(24U)牛磺酸(T)与冠心病死亡率呈显著负相关。高于平均值的24U-T排泄者的体重指数(BMI)、舒张压和收缩压(SBP, DBP)和总胆固醇(T- cho)明显低于低于平均值的T排泄者。24- u -镁(M)排泄量高于平均值的患者BMI、收缩压、舒张压和T-Cho均显著降低。因此，高于平均值的高T和M排泄者的BMI、收缩压、舒张压和T- cho明显低于低于平均值的低T和M排泄者。18世纪中叶以前的澳大利亚土著人过着狩猎和采集食物的生活，他们吃富含T和M的海鲜和坚果，因此他们被认为没有代谢综合征(MS)。然而，居住在墨尔本市区的土著居民在61个人群中MS的患病率几乎是最高的，因此，土著居民被邀请参加一项干预研究，每天从面包中摄取25g大豆蛋白，持续8周。结果表明，含大豆蛋白、大豆异黄酮和大豆M的传统东方大豆日粮具有预防CDV的作用。由于人类生命的进化起源可以追溯到富含T和M的海洋，而食物采集者以富含T和M的海鲜和丛林食物为生，因此T和M被认为对心血管健康至关重要，从而对健康长寿至关重要。摘要:山森由纪夫和森喜里
{"title":"Diets for Healthy Longevity Proven by Global Studies","authors":"Y. Yamori, M. Mori","doi":"10.3793/JAAM.7.161","DOIUrl":"https://doi.org/10.3793/JAAM.7.161","url":null,"abstract":"161 Cardiovascular Diseases (CVD) and Alimentary Comparison Study was a WHO-coordinated multi-center epidemiological survey on diets and CVD risks and mortalities in 61 populations. Twenty-four-hour urinary (24U) taurine (T) was inversely related significantly with coronary heart disease mortality. Higher 24U-T excreters over the mean had significantly lower body mass index (BMI), diastolic and systolic BP (SBP, DBP), and total cholesterol (T-Cho), than lower T excreters below the mean. Higher 24-U-magnesium (M) excreters over the mean had significantly lower BMI, SBP, DBP, and T-Cho. Therefore, higher T and M excreters over the means had significantly lower BMI, SBP, DBP and T-Cho than lower T and M excreters below the means. Australian aboriginals before the mid-18th century lived hunters’ and food gathers’ life, eating seafood and nuts rich in T and M so that they were supposed to be free from metabolic syndrome (MS). However, aboriginals living in urban Melbourne had nearly the highest prevalence of MS in 61populations and therefore, aboriginals were invited to an intervention study to take 25g of soy protein daily from breads for 8 weeks. Their CVD risks were significantly decreased, indicating traditional oriental soy diets containing soy protein, isoflavones and M could prevent CDV. Since the evolutional origin of human life was traced back to in the sea containing abundant M and food gatherers lived on seafood and bush food rich in T and M, T and M are assumed to be essential for cardiovascular health thus for healthy longevity. Abstract Yukio Yamori and Mari Mori","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"116 1","pages":"161-166"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76805350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaw Watanabe, Mikie Noboru, Misae Yasunari, T. Ideura
Background: Chronic renal failure has increased among aged population in Japan. Protein-restricted diets have been successfully used to treat chronic renal failure. However, concerns over sarcopenia and other nutritional disorders have made doctors in Japan reluctant to recommend low-protein diets.Study Design: A cross-sectional study was carried out based on dietary records, urine and blood samples and DEXA measurements to evaluate body composition.Setting & Participants: The study was carried out at Keio University Hospital and National Institute of Health and Nutrition, Tokyo, over the 3-day period in June, 2009. Subjects were 10 CKD patients (1 male, 9 female); ten members of the patients’ families (3 male, 7 female) and 11 dieticians (all female) were used as control subjects.Factor: The CKD patients maintained a daily protein intake of less than 0.5 g/kg body weight (VLPD) for periods averaging 7 years. Members of the control group all had a daily protein intake of over 1g/kg body weight.Outcomes: Indicators of nutritional disorders, metabolic abnormalities or changes in body composition were sought.Measurements: Intake of various nutrients was calculated from dietary records. Blood plasma and urine content was analyzed. Body composition was measured using DEXA.Results: The CKD subjects were found not to suffer from sarcopenia, osteoporosis, hyperkalemia, hyperphosphatemia, hyperuremia or high levels of uric acid, although slight anemia was observed. Vitamin and mineral intakes were lower than controls, but no recognizable symptoms from nutrient deficiency occurred. Urinary excretion of amino acids was different from controls.Limitations: Results are limited by the relatively small number of test subjects, variation in time on the VLPD, and gender imbalance.Conclusion: Results suggest that VLPD did not show any abnormality in body composition when energy requirement was fulfilled. Different amino acid metabolism would lead to cautious prescription of amino acid supplement.
{"title":"A Cross-Sectional Study on the Effects of Long Term Very Low Protein Diets in Patients with Chronic Kidney Disease","authors":"Shaw Watanabe, Mikie Noboru, Misae Yasunari, T. Ideura","doi":"10.3793/JAAM.7.7","DOIUrl":"https://doi.org/10.3793/JAAM.7.7","url":null,"abstract":"Background: Chronic renal failure has increased among aged population in Japan. Protein-restricted diets have been successfully used to treat chronic renal failure. However, concerns over sarcopenia and other nutritional disorders have made doctors in Japan reluctant to recommend low-protein diets.Study Design: A cross-sectional study was carried out based on dietary records, urine and blood samples and DEXA measurements to evaluate body composition.Setting & Participants: The study was carried out at Keio University Hospital and National Institute of Health and Nutrition, Tokyo, over the 3-day period in June, 2009. Subjects were 10 CKD patients (1 male, 9 female); ten members of the patients’ families (3 male, 7 female) and 11 dieticians (all female) were used as control subjects.Factor: The CKD patients maintained a daily protein intake of less than 0.5 g/kg body weight (VLPD) for periods averaging 7 years. Members of the control group all had a daily protein intake of over 1g/kg body weight.Outcomes: Indicators of nutritional disorders, metabolic abnormalities or changes in body composition were sought.Measurements: Intake of various nutrients was calculated from dietary records. Blood plasma and urine content was analyzed. Body composition was measured using DEXA.Results: The CKD subjects were found not to suffer from sarcopenia, osteoporosis, hyperkalemia, hyperphosphatemia, hyperuremia or high levels of uric acid, although slight anemia was observed. Vitamin and mineral intakes were lower than controls, but no recognizable symptoms from nutrient deficiency occurred. Urinary excretion of amino acids was different from controls.Limitations: Results are limited by the relatively small number of test subjects, variation in time on the VLPD, and gender imbalance.Conclusion: Results suggest that VLPD did not show any abnormality in body composition when energy requirement was fulfilled. Different amino acid metabolism would lead to cautious prescription of amino acid supplement.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"5 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87770222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
102 The satiating properties of fat emulsions are poorly understood. An innovative vegetable oil-in-water emulsion was studied extensively in human interventions trials, in terms of its short-term effect on energy intake, longer term appetite suppressant action and its effects on weight control parameters. The objective of this paper is to review current evidence of a vegetable emulsion in weight management. Dose-response studies with 2, 4 and 6 grams of vegetable fat (FabulessTM) (at the expense of milk fat) demonstrated sustained, but disproportional, reductions in energy intake which coincided with an appetite suppressive effect. Discrepancy however exists in the data of short-term studies with several studies also showing smaller and neutral effects. Given the variability in outcome of short-term studies on satiety and food intake, long-term studies were conducted to evaluate and confirm whether in the long-term consistent changes in body weight and or body composition would be found with this fat emulsion. Overweight women followed a weight loss regime and subsequently returned to free living conditions resulting in statistically significant weight regain. However, the vegetable fat emulsion (FabulessTM) prevented the women from regaining significant weight and also reduced waist circumference. In addition, hunger feelings were reduced, as compared to the placebo (p<0.05). To conclude, short and long-term placebo-controlled clinical studies in which dairy fat is replaced by the functional vegetable fat emulsion show effects on appetite regulation, reduction of energy intake at the next meal, and body weight maintenance after a weight loss regime. Summary
{"title":"The Role of Functional Lipids in Appetite Regulation and Weight Management","authors":"D. Bosscher, A. Viberg","doi":"10.3793/JAAM.6.102","DOIUrl":"https://doi.org/10.3793/JAAM.6.102","url":null,"abstract":"102 The satiating properties of fat emulsions are poorly understood. An innovative vegetable oil-in-water emulsion was studied extensively in human interventions trials, in terms of its short-term effect on energy intake, longer term appetite suppressant action and its effects on weight control parameters. The objective of this paper is to review current evidence of a vegetable emulsion in weight management. Dose-response studies with 2, 4 and 6 grams of vegetable fat (FabulessTM) (at the expense of milk fat) demonstrated sustained, but disproportional, reductions in energy intake which coincided with an appetite suppressive effect. Discrepancy however exists in the data of short-term studies with several studies also showing smaller and neutral effects. Given the variability in outcome of short-term studies on satiety and food intake, long-term studies were conducted to evaluate and confirm whether in the long-term consistent changes in body weight and or body composition would be found with this fat emulsion. Overweight women followed a weight loss regime and subsequently returned to free living conditions resulting in statistically significant weight regain. However, the vegetable fat emulsion (FabulessTM) prevented the women from regaining significant weight and also reduced waist circumference. In addition, hunger feelings were reduced, as compared to the placebo (p<0.05). To conclude, short and long-term placebo-controlled clinical studies in which dairy fat is replaced by the functional vegetable fat emulsion show effects on appetite regulation, reduction of energy intake at the next meal, and body weight maintenance after a weight loss regime. Summary","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"127 1","pages":"102-108"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79587900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ichihashi, H. Ando, Masaki Yoshida, Y. Niki, M. Matsui
{"title":"Photoaging of the skin","authors":"M. Ichihashi, H. Ando, Masaki Yoshida, Y. Niki, M. Matsui","doi":"10.3793/JAAM.6.46","DOIUrl":"https://doi.org/10.3793/JAAM.6.46","url":null,"abstract":"","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"93 1","pages":"46-59"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76062280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sugiyama, R. Sakakibara, Hideki Tachimoto, M. Kishi, Takayuki Kaga, I. Tabata
Objective: Acetic acid bacteria were traditionally used to produce fermented food. Furthermore, acetic acid bacteria contain unique membrane lipids that would be expected to attenuate inflammation. This study examined the effects of oral intake of acetic acid bacteria isolated from fermented milk on muscle damage after moderate-intensity exercise.Methods: In a double-blind placebo-controlled crossover trial, 40 untrained subjects (16 men and 24 women; age, 46.4 ± 4.3 yr; height, 162.8 ± 10.8 cm; weight, 60.2 ± 9.4 kg; body mass index, 22.6 ± 2.9 kg/m2) took 111 mg of dried acetic acid bacteria per day (supplemented group) or 111 mg of cornstarch per day (placebo group) for 1 week and walked for 60 min on the last day of administration. Results: Leukocyte, lymphocyte and neutrophil counts, IL-6 and creatine kinase (CK) activity, myoglobin (Mb) concentration and perceived pain in parts of the body were measured pre and post exercise. All values, except for IL-6, were significantly increased post-exercise compared with pre-exercise in both groups. However, neutrophil counts and ankle pain were significantly lower in the supplemented group. In addition, the increase of CK activity in the supplemented group was significantly attenuated at 24 h after exercise (supplemented group, 114 ± 54 U/l; placebo group, 126 ± 68 U/l). The supplemented group also demonstrated a trend toward a lower level of CK activity after exercise (p = 0.06). Other values did not differ between groups. Conclusion: These results suggested that acetic acid bacteria supplementation was useful to attenuate muscle damage after moderate-intensity exercise.
{"title":"Effects of Acetic Acid Bacteria Supplementation on Muscle Damage After Moderate-Intensity Exercise","authors":"K. Sugiyama, R. Sakakibara, Hideki Tachimoto, M. Kishi, Takayuki Kaga, I. Tabata","doi":"10.3793/JAAM.7.1","DOIUrl":"https://doi.org/10.3793/JAAM.7.1","url":null,"abstract":"Objective: Acetic acid bacteria were traditionally used to produce fermented food. Furthermore, acetic acid bacteria contain unique membrane lipids that would be expected to attenuate inflammation. This study examined the effects of oral intake of acetic acid bacteria isolated from fermented milk on muscle damage after moderate-intensity exercise.Methods: In a double-blind placebo-controlled crossover trial, 40 untrained subjects (16 men and 24 women; age, 46.4 ± 4.3 yr; height, 162.8 ± 10.8 cm; weight, 60.2 ± 9.4 kg; body mass index, 22.6 ± 2.9 kg/m2) took 111 mg of dried acetic acid bacteria per day (supplemented group) or 111 mg of cornstarch per day (placebo group) for 1 week and walked for 60 min on the last day of administration. Results: Leukocyte, lymphocyte and neutrophil counts, IL-6 and creatine kinase (CK) activity, myoglobin (Mb) concentration and perceived pain in parts of the body were measured pre and post exercise. All values, except for IL-6, were significantly increased post-exercise compared with pre-exercise in both groups. However, neutrophil counts and ankle pain were significantly lower in the supplemented group. In addition, the increase of CK activity in the supplemented group was significantly attenuated at 24 h after exercise (supplemented group, 114 ± 54 U/l; placebo group, 126 ± 68 U/l). The supplemented group also demonstrated a trend toward a lower level of CK activity after exercise (p = 0.06). Other values did not differ between groups. Conclusion: These results suggested that acetic acid bacteria supplementation was useful to attenuate muscle damage after moderate-intensity exercise.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"27 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79011982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Miyatake, Akiko Tanakai, M. Eguchi, M. Miyachi, I. Tabata, Takeyuki Numata
Objective: A device of based on the multi frequencies impedance method, named the InBody720, was developed for the purpose of estimating body composition.Methods: The performance, reliability and validity of this system were evaluated in Japanese subjects.Results: The coefficient variation (CV: %) in same-day tests was 1.96 (body fat percentage: %), 0.62 (muscle mass: kg), 0.63 (lean body mass: kg) and 1.09 (bone mineral content: kg), in three separate-day tests it was 3.59 (body fat percentage), 1.07 (muscle mass), 1.06 (lean body mass: kg) and 1.22 (bone mineral content: kg). There was a clear correlation between the results from InBody720 and those from dual energy X-ray absorptiometry (DEXA) (body fat percentage: r=0.788, p=0.0005, muscle mass: r=0.983, p<0.0001, lean body mass: r=0.984, p‹0.0001, bone mineral content: r=0.759, p=0.0010).Conclusion: The findings indicate that this device is a highly reliable and valid method for determining body composition. This method has several advantages e.g. it is quick, simple to operate and may accommodate wide population.
{"title":"Reference Data of Multi Frequencies Bioelectric Impedance Method in Japanese","authors":"N. Miyatake, Akiko Tanakai, M. Eguchi, M. Miyachi, I. Tabata, Takeyuki Numata","doi":"10.3793/JAAM.6.10","DOIUrl":"https://doi.org/10.3793/JAAM.6.10","url":null,"abstract":"Objective: A device of based on the multi frequencies impedance method, named the InBody720, was developed for the purpose of estimating body composition.Methods: The performance, reliability and validity of this system were evaluated in Japanese subjects.Results: The coefficient variation (CV: %) in same-day tests was 1.96 (body fat percentage: %), 0.62 (muscle mass: kg), 0.63 (lean body mass: kg) and 1.09 (bone mineral content: kg), in three separate-day tests it was 3.59 (body fat percentage), 1.07 (muscle mass), 1.06 (lean body mass: kg) and 1.22 (bone mineral content: kg). There was a clear correlation between the results from InBody720 and those from dual energy X-ray absorptiometry (DEXA) (body fat percentage: r=0.788, p=0.0005, muscle mass: r=0.983, p<0.0001, lean body mass: r=0.984, p‹0.0001, bone mineral content: r=0.759, p=0.0010).Conclusion: The findings indicate that this device is a highly reliable and valid method for determining body composition. This method has several advantages e.g. it is quick, simple to operate and may accommodate wide population.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"1 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84005143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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