Recently, many developing countries have had changes in the composition of population and have become aging societies. Therefore, anti-aging medicine which is believed to have beneficial effect on the risk factors of geriatric associated diseases has been paid much attention. Complementary and alternative medicine (CAM) has been widely accepted by the general population, and is consequently known to account for a large share of health care costs in many countries.Hormone therapy (HT) is the gold standard to alleviate menopausal symptoms, but only 2.3% of Korean menopausal women are on HT. Many other women seek alternative means, including Korean traditional medicine, phytoestrogen-containing products such as black cohosh, soy (isoflavone), Dong quai, Ginseng, and evening primrose oil. Bioidential hormone therapy (BHT) is HT with individually compounded recipes of steroids in various doses. Its efficacy is yet to be confirmed and the risks of developing endometrial hyperplasia and breast cancer have been reported. Other CAM methods involving lifestyle and behavioral interventions include exercise, caloric restriction, weight reduction, and ‘mind-body medicine (homeopathy).’ Dermatologic, plastic, and ophthalmologic interventions have been introduced through the exhibition, as well.Physicians have ignored this novel trend of patients preference to ‘natural hormonal therapy,’ however, they should be aware of the pros and cons of CAM and be able to guide their patients to make right choices. Clinical trials, and the evaluation of every CAM practice should be undertaken.
{"title":"Current Status of Anti-Aging Medicine, Especially Involving Management of the Menopause, as a Component of Complementary and Alternative Medicine in Korea","authors":"Hyun Kim, Hoon Kim, Jung-Ho Shin, S. Ku","doi":"10.3793/JAAM.6.95","DOIUrl":"https://doi.org/10.3793/JAAM.6.95","url":null,"abstract":"Recently, many developing countries have had changes in the composition of population and have become aging societies. Therefore, anti-aging medicine which is believed to have beneficial effect on the risk factors of geriatric associated diseases has been paid much attention. Complementary and alternative medicine (CAM) has been widely accepted by the general population, and is consequently known to account for a large share of health care costs in many countries.Hormone therapy (HT) is the gold standard to alleviate menopausal symptoms, but only 2.3% of Korean menopausal women are on HT. Many other women seek alternative means, including Korean traditional medicine, phytoestrogen-containing products such as black cohosh, soy (isoflavone), Dong quai, Ginseng, and evening primrose oil. Bioidential hormone therapy (BHT) is HT with individually compounded recipes of steroids in various doses. Its efficacy is yet to be confirmed and the risks of developing endometrial hyperplasia and breast cancer have been reported. Other CAM methods involving lifestyle and behavioral interventions include exercise, caloric restriction, weight reduction, and ‘mind-body medicine (homeopathy).’ Dermatologic, plastic, and ophthalmologic interventions have been introduced through the exhibition, as well.Physicians have ignored this novel trend of patients preference to ‘natural hormonal therapy,’ however, they should be aware of the pros and cons of CAM and be able to guide their patients to make right choices. Clinical trials, and the evaluation of every CAM practice should be undertaken.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"1 1","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74939939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Double filtration plasmapheresis (DFPP) removal of LDL cholesterol (LDL-C) and other pathogenic substances in the blood has attracted attention as an effective treatment of arteriosclerotic lesions. We conducted a controlled open-label study to understand the physical and mental effects of DFPP.Methods: Seven (7) male patients with borderline hyper-LDL-C (134.0±41.1 mg/dL) were assigned to a DFPP group (age 43.0±5.3 years, BMI 26.0±4.5) and 7 others were assigned to a control group (age 39.1±11.4 years, BMI 28.9±8.1). The observation period was 8 weeks. Patients in the DFPP group received DFPP twice. The evaluation included the Anti-Aging QOL Common Questionnaire (AAQol) and the blood vessel tests of Pulse wave velocity (PWV) and ankle-brachial index (ABI).Results: Among physical symptoms in AAQol, “tired eyes,” “blurry eyes,” “stiff shoulders,” and “feeling of ill-health” significantly decreased after 8 weeks in the DFPP group. Hematology revealed that hemoglobin (+3.6%, p=0.047), total protein (+4.1%, p=0.019), and albumin (+4.9%, p=0.018) were maintained at higher levels after 8 weeks in the DFPP group than the control group. Despite LDL-C removal, the hepatic steatosis index ALT (+5.7%, p=0.008) and lipid metabolism index LDL-C (+11.6%, p=0.012) were apparently higher in the DFPP group. Endocrinology showed a decreasing trend of DHEA-s (−13.7%, p=0.003), increasing trend of cortisol (+27.5%, p=0.005), and increasing trend of progesterone (+50%, p=0.030) in the DFPP group compared with the control group. High-sensitivity CRP tended to decrease in the DFPP group compared with the control group (−26.5%, p=0.030). There was no significant change in PWV or ABI in the DFPP group. No serious adverse events were caused by DFPP.Conclusion: LDL-C removal by DFPP might suppress inflammation and improve tissue environment in visceral adipose and liver tissues with fatty deposits.
{"title":"Effect of Double Filtration Plasmapheresis (DFPP) in Male Patients with Borderline Hyper-LDL-cholesterolemia : Lipid Removal and Inflammation Suppression","authors":"S. Hibino, Y. Seok, H. Tsuda, Y. Yonei","doi":"10.3793/JAAM.6.32","DOIUrl":"https://doi.org/10.3793/JAAM.6.32","url":null,"abstract":"Objective: Double filtration plasmapheresis (DFPP) removal of LDL cholesterol (LDL-C) and other pathogenic substances in the blood has attracted attention as an effective treatment of arteriosclerotic lesions. We conducted a controlled open-label study to understand the physical and mental effects of DFPP.Methods: Seven (7) male patients with borderline hyper-LDL-C (134.0±41.1 mg/dL) were assigned to a DFPP group (age 43.0±5.3 years, BMI 26.0±4.5) and 7 others were assigned to a control group (age 39.1±11.4 years, BMI 28.9±8.1). The observation period was 8 weeks. Patients in the DFPP group received DFPP twice. The evaluation included the Anti-Aging QOL Common Questionnaire (AAQol) and the blood vessel tests of Pulse wave velocity (PWV) and ankle-brachial index (ABI).Results: Among physical symptoms in AAQol, “tired eyes,” “blurry eyes,” “stiff shoulders,” and “feeling of ill-health” significantly decreased after 8 weeks in the DFPP group. Hematology revealed that hemoglobin (+3.6%, p=0.047), total protein (+4.1%, p=0.019), and albumin (+4.9%, p=0.018) were maintained at higher levels after 8 weeks in the DFPP group than the control group. Despite LDL-C removal, the hepatic steatosis index ALT (+5.7%, p=0.008) and lipid metabolism index LDL-C (+11.6%, p=0.012) were apparently higher in the DFPP group. Endocrinology showed a decreasing trend of DHEA-s (−13.7%, p=0.003), increasing trend of cortisol (+27.5%, p=0.005), and increasing trend of progesterone (+50%, p=0.030) in the DFPP group compared with the control group. High-sensitivity CRP tended to decrease in the DFPP group compared with the control group (−26.5%, p=0.030). There was no significant change in PWV or ABI in the DFPP group. No serious adverse events were caused by DFPP.Conclusion: LDL-C removal by DFPP might suppress inflammation and improve tissue environment in visceral adipose and liver tissues with fatty deposits.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"64 1","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85056873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Aiba, Shaw Watanabe, A. Morita, Naomi Suda, H. Taguchi, M. Miyachi
BACKGROUND: Long-term weight loss is difficult to maintain, but recently cognitive behavioral therapy has been shown to be effective for long-term weight loss and maintenance.METHODS: The 119 participants, who had been assigned to program to lose weight, were interviewed by dieticians regarding their motivation for weight loss and psychological status and self-corrected problems with their eating activities and exercises, following recognition of problems, discussing solutions, and devising personal dietary plans and exercise plan to loose weight at 1.0-2.0 kg per month.RESULTS: In women, the prevalence of motivation to resolve the situation (n = 44, 84.6%) was significantly higher than that of men (n = 33, 67.3%; p < 0.05). In men, awareness of the need to keep healthy by oneself was significantly associated with the motivation to resolve the situation (p = 0.002) and the availability of support from others (p = 0.004). Thirty problems and 29 dietary goals were set by participants. The percentages of intake of alcohol (p < 0.05) and intake of sweets (p < 0.01) as the problems and decrease of intake in specified foods (p < 0.01) and snacks (p = 0.05) as dietary goals were significantly different between men and women. Women with BMI over 31 kg/m² set fewer additional steps as exercise goals than those with BMI under 29 kg/m² (p < 0.05).CONCLUSIONS: The characters of subjects such as psychological status and the problems and the target recognized by participants were different between gender and the degree of obesity.
{"title":"Nutritional Education and Exercise Treatment Based on Cognitive Behavioral Treatment in the Saku Control Obesity Program (SCOP)","authors":"N. Aiba, Shaw Watanabe, A. Morita, Naomi Suda, H. Taguchi, M. Miyachi","doi":"10.3793/JAAM.5.39","DOIUrl":"https://doi.org/10.3793/JAAM.5.39","url":null,"abstract":"BACKGROUND: Long-term weight loss is difficult to maintain, but recently cognitive behavioral therapy has been shown to be effective for long-term weight loss and maintenance.METHODS: The 119 participants, who had been assigned to program to lose weight, were interviewed by dieticians regarding their motivation for weight loss and psychological status and self-corrected problems with their eating activities and exercises, following recognition of problems, discussing solutions, and devising personal dietary plans and exercise plan to loose weight at 1.0-2.0 kg per month.RESULTS: In women, the prevalence of motivation to resolve the situation (n = 44, 84.6%) was significantly higher than that of men (n = 33, 67.3%; p < 0.05). In men, awareness of the need to keep healthy by oneself was significantly associated with the motivation to resolve the situation (p = 0.002) and the availability of support from others (p = 0.004). Thirty problems and 29 dietary goals were set by participants. The percentages of intake of alcohol (p < 0.05) and intake of sweets (p < 0.01) as the problems and decrease of intake in specified foods (p < 0.01) and snacks (p = 0.05) as dietary goals were significantly different between men and women. Women with BMI over 31 kg/m² set fewer additional steps as exercise goals than those with BMI under 29 kg/m² (p < 0.05).CONCLUSIONS: The characters of subjects such as psychological status and the problems and the target recognized by participants were different between gender and the degree of obesity.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"43 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89068966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Age-related macular degeneration (AMD) is one of the most severe vision-threatening diseases. Wet AMD, caused by choroidal neovascularization (CNV), progresses rapidly, while dry AMD, characterized by neural retinal atrophy followed by choroidal vascular atrophy, progresses slowly. In addition to systemic risk factors, such as a high body-mass index (BMI), smoking, hypertension, and atherosclerosis, light-induced local oxidative stress and inflammation promotes AMD. CNV can be induced by multiple pathways. The accumulation of lipofuscin, a product of the undigested outer segments of photoreceptor cells, causes chronic local inflammation. Extracellular lipoprotein deposits, which contain pro-inflammatory components, such as complement, can trigger local inflammation. A single nucleotide polymorphism (SNP) in some genes; i.e., complement factor H (CFH) and excision repair cross-complementing rodent repair deficiency complementation group 6 (ERCC6), which induce local inflammation, is a risk factor for AMD. Two treatments, photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy, have been approved worldwide to cause the regression of CNV. In addition, the suppression of CNV progression combined with retinal neural protection by anti-oxidative reagents such as lutein/zeaxanthin and/or docosahexaenoic acid / eicosapentaenoic acid (DHA/EPA) is a promising prospective therapeutic approach. This is the subject of an ongoing prospective, randomized, double-blind, multicenter clinical trial, the Age-Related Eye Disease Study 2 (AREDS2). In addition, molecular and biological analyses in animal models have provided data supporting this anti-oxidant therapy.
{"title":"Age-related macular degeneration (AMD); From pathogenesis and approved therapies to proposed treatments for prevention","authors":"Y. Ozawa, S. Ishida, K. Tsubota","doi":"10.3793/JAAM.5.87","DOIUrl":"https://doi.org/10.3793/JAAM.5.87","url":null,"abstract":"Age-related macular degeneration (AMD) is one of the most severe vision-threatening diseases. Wet AMD, caused by choroidal neovascularization (CNV), progresses rapidly, while dry AMD, characterized by neural retinal atrophy followed by choroidal vascular atrophy, progresses slowly. In addition to systemic risk factors, such as a high body-mass index (BMI), smoking, hypertension, and atherosclerosis, light-induced local oxidative stress and inflammation promotes AMD. CNV can be induced by multiple pathways. The accumulation of lipofuscin, a product of the undigested outer segments of photoreceptor cells, causes chronic local inflammation. Extracellular lipoprotein deposits, which contain pro-inflammatory components, such as complement, can trigger local inflammation. A single nucleotide polymorphism (SNP) in some genes; i.e., complement factor H (CFH) and excision repair cross-complementing rodent repair deficiency complementation group 6 (ERCC6), which induce local inflammation, is a risk factor for AMD. Two treatments, photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy, have been approved worldwide to cause the regression of CNV. In addition, the suppression of CNV progression combined with retinal neural protection by anti-oxidative reagents such as lutein/zeaxanthin and/or docosahexaenoic acid / eicosapentaenoic acid (DHA/EPA) is a promising prospective therapeutic approach. This is the subject of an ongoing prospective, randomized, double-blind, multicenter clinical trial, the Age-Related Eye Disease Study 2 (AREDS2). In addition, molecular and biological analyses in animal models have provided data supporting this anti-oxidant therapy.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"78 1","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74020886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Numerous studies have been conducted to research substances useful for preventing or reducing pigmentation in the skin. Pigment spot is a serious cosmetic concern, particularly for the Asian elderly. Oral ingestion of antioxidant supplements is known to prevent skin pigmentation. Glutathione is an intracellular antioxidant that plays an important role in cell protection against oxidative stress and shows antimelanogenic activity. In our previous study, it was shown that olive leaf extract stimulated intracellular glutathione synthesis in human fibroblasts, melanocytes and keratinocytes. Here, a double-blind placebo-controlled study was performed to investigate whether the ingestion of a supplement containing olive leaf extract, L-cystine and ascorbic acid affects tanning of skin induced by ultraviolet (UV) irradiation. We determined the minimal erythema dose (MED) in 24 healthy volunteers before and after supplementation. Small sites on the subjects'arms were exposed to UV light for three successive days, and subjects were then administered tablets containing 47.7 mg olive leaf extract, 40.0 mg L-cystine and 50.0 mg ascorbic acid every day for 8 weeks. The present study showed that the subjects'MED increased significantly after an 8-week course of supplementation. The increment of skin lightness at the sites of UV irradiation from Day 10 to Day 17 was significantly higher in the test sample group than in subjects who received a placebo. These results suggest that the supplement containing olive leaf extract, L-cystine and ascorbic acid reduces UV-induced erythema and tanning by its antioxidative activity.
已经进行了大量的研究来研究防止或减少皮肤色素沉着的物质。色素斑是一个严重的美容问题，尤其是对亚洲老年人来说。口服抗氧化剂补充剂可以防止皮肤色素沉着。谷胱甘肽是一种细胞内抗氧化剂，在细胞抗氧化应激和抗黑素生成中起重要作用。在我们之前的研究中，我们发现橄榄叶提取物刺激了人成纤维细胞、黑色素细胞和角化细胞的细胞内谷胱甘肽合成。本研究进行了一项双盲安慰剂对照研究，以调查摄入含有橄榄叶提取物、l -胱氨酸和抗坏血酸的补充剂是否会影响紫外线照射诱导的皮肤晒黑。我们测定了24名健康志愿者在补充前后的最小红斑剂量(MED)。受试者手臂上的小部位连续三天暴露在紫外线下，然后每天给受试者服用含有47.7 mg橄榄叶提取物、40.0 mg l -胱氨酸和50.0 mg抗坏血酸的片剂，持续8周。本研究表明，在8周的补充疗程后，受试者的med显著增加。从第10天到第17天，测试样本组在紫外线照射部位的皮肤亮度增量明显高于接受安慰剂的受试者。上述结果表明，橄榄叶提取物、l -胱氨酸和抗坏血酸通过其抗氧化活性降低了紫外线诱导的红斑和晒黑。
{"title":"Effect of a Supplement Containing Olive Leaf Extract against Ultraviolet Light-Induced Tanning: A Double-Blind Placebo-Controlled Study","authors":"I. Kaneko, T. Chiba, Kohsuke Hayamizu, T. Tsuji","doi":"10.3793/JAAM.5.78","DOIUrl":"https://doi.org/10.3793/JAAM.5.78","url":null,"abstract":"Numerous studies have been conducted to research substances useful for preventing or reducing pigmentation in the skin. Pigment spot is a serious cosmetic concern, particularly for the Asian elderly. Oral ingestion of antioxidant supplements is known to prevent skin pigmentation. Glutathione is an intracellular antioxidant that plays an important role in cell protection against oxidative stress and shows antimelanogenic activity. In our previous study, it was shown that olive leaf extract stimulated intracellular glutathione synthesis in human fibroblasts, melanocytes and keratinocytes. Here, a double-blind placebo-controlled study was performed to investigate whether the ingestion of a supplement containing olive leaf extract, L-cystine and ascorbic acid affects tanning of skin induced by ultraviolet (UV) irradiation. We determined the minimal erythema dose (MED) in 24 healthy volunteers before and after supplementation. Small sites on the subjects'arms were exposed to UV light for three successive days, and subjects were then administered tablets containing 47.7 mg olive leaf extract, 40.0 mg L-cystine and 50.0 mg ascorbic acid every day for 8 weeks. The present study showed that the subjects'MED increased significantly after an 8-week course of supplementation. The increment of skin lightness at the sites of UV irradiation from Day 10 to Day 17 was significantly higher in the test sample group than in subjects who received a placebo. These results suggest that the supplement containing olive leaf extract, L-cystine and ascorbic acid reduces UV-induced erythema and tanning by its antioxidative activity.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"79 8 1","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82638416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kikuchi, H. Nakagami, T. Katsuya, R. Morishita, T. Horio, K. Kamide, T. Miyata, Y. Kawano, Y. Takami, H. Rakugi, Y. Kaneda, T. Ogihara
BACKGROUND: With aging, left ventricle diastolic dysfunction due to pressure overload is an independent risk factor for morbidity and mortality. Mechanisms by which alterations in stretch-induced mechanotransduction contribute to left ventricular diastolic dysfunction remain unclear. Recently, since novel Z-disc related protein, myospryn, expressed in striated muscle cells, has been reported, we examined the relationship between myospryn polymorphisms and alterations in cardiac function with patients in larger population. METHODS: A total of 743 patients with high blood pressure (defined as systolic blood pressure >140 mmHg and/or systolic blood pressure >90 mmHg or taking antihypertensive medication) were enrolled in this study. Two-dimensional ultrasound echocardiography, electrocardiography, blood pressure, serum glucose, cholesterol, creatinine, uric acid, and myospryn K2906N polymorphism. RESULTS: The myospryn K2906N polymorphism was significantly associated with a marker of left ventricular diastolic cardiac dysfunction, A/E, which represents the ratio of the peak velocity of the early diastolic filling wave (E wave) to the atrial filling (A wave). CONCLUSIONS: These data demonstrated that a polymorphism of myospryn was associated with left ventricular diastolic dysfunction in hypertensive patients and provided the novel therapeutic target for cardiac adaptation in response to pressure overload as an anti-aging therapy.
{"title":"Polymorphism of myospryn is associated with left ventricular diastolic dysfunction","authors":"Y. Kikuchi, H. Nakagami, T. Katsuya, R. Morishita, T. Horio, K. Kamide, T. Miyata, Y. Kawano, Y. Takami, H. Rakugi, Y. Kaneda, T. Ogihara","doi":"10.3793/JAAM.5.49","DOIUrl":"https://doi.org/10.3793/JAAM.5.49","url":null,"abstract":"BACKGROUND: With aging, left ventricle diastolic dysfunction due to pressure overload is an independent risk factor for morbidity and mortality. Mechanisms by which alterations in stretch-induced mechanotransduction contribute to left ventricular diastolic dysfunction remain unclear. Recently, since novel Z-disc related protein, myospryn, expressed in striated muscle cells, has been reported, we examined the relationship between myospryn polymorphisms and alterations in cardiac function with patients in larger population. METHODS: A total of 743 patients with high blood pressure (defined as systolic blood pressure >140 mmHg and/or systolic blood pressure >90 mmHg or taking antihypertensive medication) were enrolled in this study. Two-dimensional ultrasound echocardiography, electrocardiography, blood pressure, serum glucose, cholesterol, creatinine, uric acid, and myospryn K2906N polymorphism. RESULTS: The myospryn K2906N polymorphism was significantly associated with a marker of left ventricular diastolic cardiac dysfunction, A/E, which represents the ratio of the peak velocity of the early diastolic filling wave (E wave) to the atrial filling (A wave). CONCLUSIONS: These data demonstrated that a polymorphism of myospryn was associated with left ventricular diastolic dysfunction in hypertensive patients and provided the novel therapeutic target for cardiac adaptation in response to pressure overload as an anti-aging therapy.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"94 1","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83942030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yonei, Y. Miwa, S. Hibino, Yoko Takahashi, R. Miyazaki, Toshikazu Yoshikawa, H. Moriwaki, Tsutomu Hasegawa, T. Hiraishi, Kazuhisa Torii
Faculty of Life and Medical Sciences, Doshisha University 1-3, Tatara Miyakotani, Kyotanabe, Kyoto 610-0321, Japan Tel: +81-774-65-6394 / FAX: +81-774-65-6394 / E-mail: yyonei@mail.doshisha.ac.jp Anti-Aging Medicine 5 (6) : 63-72, 2008 (c) Japanese Society of Anti-Aging Medicine Original Article Japanese Anthropometric Reference Data – Special Emphasis on Bioelectrical Impedance Analysis of Muscle Mass
日本同社大学生命与医学科学学院1-3，宫谷Tatara, Kyotanabe, Kyoto 610-0321, Japan Tel: +81-774-65-6394 / FAX: +81-774-65-6394 / E-mail: yyonei@mail.doshisha.ac.jp Anti-Aging Medicine 5 (6): 63- 72,2008 (c) Japan Society of Anti-Aging Medicine原创文章日本人体测量参考数据-特别强调肌肉质量的生物电阻抗分析
{"title":"Japanese Anthropometric Reference Data - Special Emphasis on Bioelectrical Impedance Analysis of Muscle Mass","authors":"Y. Yonei, Y. Miwa, S. Hibino, Yoko Takahashi, R. Miyazaki, Toshikazu Yoshikawa, H. Moriwaki, Tsutomu Hasegawa, T. Hiraishi, Kazuhisa Torii","doi":"10.3793/JAAM.5.63","DOIUrl":"https://doi.org/10.3793/JAAM.5.63","url":null,"abstract":"Faculty of Life and Medical Sciences, Doshisha University 1-3, Tatara Miyakotani, Kyotanabe, Kyoto 610-0321, Japan Tel: +81-774-65-6394 / FAX: +81-774-65-6394 / E-mail: yyonei@mail.doshisha.ac.jp Anti-Aging Medicine 5 (6) : 63-72, 2008 (c) Japanese Society of Anti-Aging Medicine Original Article Japanese Anthropometric Reference Data – Special Emphasis on Bioelectrical Impedance Analysis of Muscle Mass","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"15 1","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87294530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Miyachi, Yumi Ohmori, Kenta Yamamoto, H. Kawano, H. Murakami, A. Morita, Shaw Watanabe
INTRODUCTION: Energy expenditure (EE) associated with physical activity is negatively correlated with prevalence of obesity and related diseases, and exercise plays a major role in prevention and treatment of these diseases. We determined baseline daily step-count and physical activity-related energy expenditure (PAEE) in 230 obese subjects (40-64 years old) participating in the Saku Control Obesity Program. The secondary purpose of this study was to determine the association between abdominal fat and amount of physical activity. METHODS: Daily step-count and PAEE were measured using a uniaxial accelerometer. The subjects wore the uniaxial accelerometer on their belt from the time they woke up until going to bed for 2 weeks. Adjusted PAEE (METs·h/day) was calculated based on daily PAEE and body weight.RESULTS AND CONCLUSIONS: Daily step-count, PAEE, and adjusted PAEE were 7,815±3,211 (mean±SD) steps/day, 258±115 kcal/day, and 3.09±1.38 METs·h/day, respectively. There were no significant differences in daily step-count or adjusted PAEE between men and women. Daily step-count and adjusted PAEE were somewhat lower than the reference values for the quantity of physical activity for health promotion (8,000-10,000 steps/day and 3.3 METs·h/day) established by the Ministry of Health, Labour, and Welfare of Japan. BMI, visceral fat area, and abdominal circumference were negatively and weakly correlated with daily step-count and adjusted PAEE (r=−0.13 to −0.19, P<0.05 to 0.01). These results suggest that the amount of physical activity assessed by uniaxial accelerometry is partially associated with not only systemic obesity but also abdominal obesity.
{"title":"The Use of a Uniaxial Accelerometer to Assess Physical-activity-related Energy Expenditure in Obese Men and Women: Saku Control Obesity Program (SCOP)","authors":"M. Miyachi, Yumi Ohmori, Kenta Yamamoto, H. Kawano, H. Murakami, A. Morita, Shaw Watanabe","doi":"10.3793/JAAM.5.1","DOIUrl":"https://doi.org/10.3793/JAAM.5.1","url":null,"abstract":"INTRODUCTION: Energy expenditure (EE) associated with physical activity is negatively correlated with prevalence of obesity and related diseases, and exercise plays a major role in prevention and treatment of these diseases. We determined baseline daily step-count and physical activity-related energy expenditure (PAEE) in 230 obese subjects (40-64 years old) participating in the Saku Control Obesity Program. The secondary purpose of this study was to determine the association between abdominal fat and amount of physical activity. METHODS: Daily step-count and PAEE were measured using a uniaxial accelerometer. The subjects wore the uniaxial accelerometer on their belt from the time they woke up until going to bed for 2 weeks. Adjusted PAEE (METs·h/day) was calculated based on daily PAEE and body weight.RESULTS AND CONCLUSIONS: Daily step-count, PAEE, and adjusted PAEE were 7,815±3,211 (mean±SD) steps/day, 258±115 kcal/day, and 3.09±1.38 METs·h/day, respectively. There were no significant differences in daily step-count or adjusted PAEE between men and women. Daily step-count and adjusted PAEE were somewhat lower than the reference values for the quantity of physical activity for health promotion (8,000-10,000 steps/day and 3.3 METs·h/day) established by the Ministry of Health, Labour, and Welfare of Japan. BMI, visceral fat area, and abdominal circumference were negatively and weakly correlated with daily step-count and adjusted PAEE (r=−0.13 to −0.19, P<0.05 to 0.01). These results suggest that the amount of physical activity assessed by uniaxial accelerometry is partially associated with not only systemic obesity but also abdominal obesity.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"25 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87391957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Accumulation of end-stage products of the Maillard reaction, also called advanced glycation end products (AGEs), is a hallmark of aging and the pathogenesis of chronic diabetic complications. The aim of this study was to determine whether safe and effective substances contained in four extracts of foodstuffs might slow the development of diabetic complications as well as slow the progression of aging.Design: We evaluated the in-vitro activity of four extracts of dried herbs available in Japan (Anthemis nobilis, Crataegus oxyacantha, Houttuynia coradata, Vitis vinifera) and a mixture of these to inhibit the Maillard reaction. We also assessed whether a 12-week feeding of mixed herbal extract (MHE) admixed in MF chow to streptozotocin (STZ)-induced diabetic rats prevented the development of diabetic complications.Results: Each of the four herbal extracts as well as the mixed extract dose-dependently inhibited the generation of Maillard reaction products in vitro with a potency similar to that of aminoguanidine (AG), a drug used for treating diabetic complications. Furthermore, after a 12-week, MHE supplemental feeding to STZ-induced diabetic rats, serum pentosidine and Ne-(carboxymethyl)lysine levels and wet weight of the kidney tended to decrease. MHE elicited AG-like actions and produced an inhibitory effect on pentosidine generation at lower concentrations than those observed for AG.Conclusion: Through the inhibition of the Maillard reaction, MHE may slow the development of chronic diabetic complications as well as slow the progression of aging.
{"title":"Herbal extracts inhibit Maillard reaction, and reduce chronic diabetic complications risk in streptozotocin-induced diabetic rats","authors":"Y. Yonei, M. Yagi, S. Hibino, N. Matsuura","doi":"10.3793/JAAM.5.93","DOIUrl":"https://doi.org/10.3793/JAAM.5.93","url":null,"abstract":"Objectives: Accumulation of end-stage products of the Maillard reaction, also called advanced glycation end products (AGEs), is a hallmark of aging and the pathogenesis of chronic diabetic complications. The aim of this study was to determine whether safe and effective substances contained in four extracts of foodstuffs might slow the development of diabetic complications as well as slow the progression of aging.Design: We evaluated the in-vitro activity of four extracts of dried herbs available in Japan (Anthemis nobilis, Crataegus oxyacantha, Houttuynia coradata, Vitis vinifera) and a mixture of these to inhibit the Maillard reaction. We also assessed whether a 12-week feeding of mixed herbal extract (MHE) admixed in MF chow to streptozotocin (STZ)-induced diabetic rats prevented the development of diabetic complications.Results: Each of the four herbal extracts as well as the mixed extract dose-dependently inhibited the generation of Maillard reaction products in vitro with a potency similar to that of aminoguanidine (AG), a drug used for treating diabetic complications. Furthermore, after a 12-week, MHE supplemental feeding to STZ-induced diabetic rats, serum pentosidine and Ne-(carboxymethyl)lysine levels and wet weight of the kidney tended to decrease. MHE elicited AG-like actions and produced an inhibitory effect on pentosidine generation at lower concentrations than those observed for AG.Conclusion: Through the inhibition of the Maillard reaction, MHE may slow the development of chronic diabetic complications as well as slow the progression of aging.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"35 1","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75280567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The mdx mouse, a model of muscular dystrophy, lacks dystrophin, a cell membrane protein. It is known that this lack of dystrophin results in muscle fiber necrosis from 2 weeks after birth, and the majority of necrotic fibers are replaced by regenerated fibers by 4 weeks of age. Recent studies reported the detection of mitochondrial and endoplasmic reticulum stress proteins during muscle fiber necrosis in mdx mice, but did not histologically localize them to determine the timing of their expression during the process from cell necrosis to regeneration. Therefore, in this study, we investigated histological localization and gene-level expression in the mdx mouse masseter muscle of caspase-12 protein (among the caspases, which are cell stress-related genes) involved in the endoplasmic reticulum stress pathway. We observed caspase-12 expression in muscle cells that seemed to be in the process of necrosis in the mdx mouse masseter muscle at 2 weeks after birth, but not in regenerated muscle cells with centrally located nuclei observed at 3 to 4 weeks of age. These results suggest that due to the lack of dystrophin, it becomes difficult for muscle cells to maintain their morphology, and endoplasmic reticulum stress occurs to maintain cell morphology during the process of cell necrosis.
{"title":"Localization of caspase 12 in masseter muscle of mdx mice during regeneration","authors":"S. Abe","doi":"10.3793/JAAM.5.53","DOIUrl":"https://doi.org/10.3793/JAAM.5.53","url":null,"abstract":"The mdx mouse, a model of muscular dystrophy, lacks dystrophin, a cell membrane protein. It is known that this lack of dystrophin results in muscle fiber necrosis from 2 weeks after birth, and the majority of necrotic fibers are replaced by regenerated fibers by 4 weeks of age. Recent studies reported the detection of mitochondrial and endoplasmic reticulum stress proteins during muscle fiber necrosis in mdx mice, but did not histologically localize them to determine the timing of their expression during the process from cell necrosis to regeneration. Therefore, in this study, we investigated histological localization and gene-level expression in the mdx mouse masseter muscle of caspase-12 protein (among the caspases, which are cell stress-related genes) involved in the endoplasmic reticulum stress pathway. We observed caspase-12 expression in muscle cells that seemed to be in the process of necrosis in the mdx mouse masseter muscle at 2 weeks after birth, but not in regenerated muscle cells with centrally located nuclei observed at 3 to 4 weeks of age. These results suggest that due to the lack of dystrophin, it becomes difficult for muscle cells to maintain their morphology, and endoplasmic reticulum stress occurs to maintain cell morphology during the process of cell necrosis.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"121 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73250863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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