Objective: Exogenous hydrogen sulfide (H2S) has a positive effect on respiratory diseases. Oleo-gum of Ferula assa-foetida contains this compound. This study assessed the effects of Ferula assa-foetida L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19.
Materials and methods: A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO2) were the endpoints.
Results: Mean±SD of PO2 in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively.
Conclusion: Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.
{"title":"The effect of Phytopaj <i>)</i> <i>Ferula assa-foetida</i> L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial.","authors":"Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi","doi":"10.22038/AJP.2023.22800","DOIUrl":"10.22038/AJP.2023.22800","url":null,"abstract":"<p><strong>Objective: </strong>Exogenous hydrogen sulfide (H<sub>2</sub>S) has a positive effect on respiratory diseases. Oleo-gum of <i>Ferula assa-foetida</i> contains this compound. This study assessed the effects of <i>Ferula assa-foetida</i> L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19.</p><p><strong>Materials and methods: </strong>A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO<sub>2</sub>) were the endpoints.</p><p><strong>Results: </strong>Mean±SD of PO<sub>2</sub> in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively.</p><p><strong>Conclusion: </strong>Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.
Materials and methods: In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV1). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.
Results: Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV1 was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.
Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.
{"title":"Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial.","authors":"Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi","doi":"10.22038/AJP.2023.22826","DOIUrl":"10.22038/AJP.2023.22826","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.</p><p><strong>Materials and methods: </strong>In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV<sub>1</sub>). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.</p><p><strong>Results: </strong>Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV<sub>1</sub> was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.</p><p><strong>Conclusion: </strong>Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Despite an increasing number of studies, there is as yet no definite treatment developed for the coronavirus disease 2019 (COVID-19). In this clinical trial, we examined the efficacy of a novel herbal antiviral preparation in critically ill COVID-19 patients.
Materials and methods: A total number of 120 ICU-admitted patients with a diagnosis of COVID-19 pneumonia were recruited to the trial. Participants were equally randomized to receive either the novel antiviral preparation sublingually, for up to two consecutive weeks or till discharge, or placebo. Clinical and laboratory parameters as well as survival rates were compared between the two groups.
Results: The cumulative incidence of death throughout the study period was 8.33% in the intervention group and 60% in the placebo group (risk ratio: 0.14; 95% confidence interval [CI], 0.05 to 0.32; p<0.001). On day 7, several parameters including white blood cells (WBCs) count, C-reactive protein, and SpO2 were improved for the treatment group compared with the placebo group (p-values of 0.05, 0.01, and <0.001, respectively).
Conclusion: This preparation might be suggested as a potentially promising COVID-19 treatment.
{"title":"Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial.","authors":"","doi":"10.22038/AJP.2023.23259","DOIUrl":"10.22038/AJP.2023.23259","url":null,"abstract":"<p><strong>Objective: </strong>Despite an increasing number of studies, there is as yet no definite treatment developed for the coronavirus disease 2019 (COVID-19). In this clinical trial, we examined the efficacy of a novel herbal antiviral preparation in critically ill COVID-19 patients.</p><p><strong>Materials and methods: </strong>A total number of 120 ICU-admitted patients with a diagnosis of COVID-19 pneumonia were recruited to the trial. Participants were equally randomized to receive either the novel antiviral preparation sublingually, for up to two consecutive weeks or till discharge, or placebo. Clinical and laboratory parameters as well as survival rates were compared between the two groups.</p><p><strong>Results: </strong>The cumulative incidence of death throughout the study period was 8.33% in the intervention group and 60% in the placebo group (risk ratio: 0.14; 95% confidence interval [CI], 0.05 to 0.32; p<0.001). On day 7, several parameters including white blood cells (WBCs) count, C-reactive protein, and SpO<sub>2</sub> were improved for the treatment group compared with the placebo group (p-values of 0.05, 0.01, and <0.001, respectively).</p><p><strong>Conclusion: </strong>This preparation might be suggested as a potentially promising COVID-19 treatment.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Most polycystic ovary syndrome (PCOS) patients have metabolic abnormalities in which insulin resistance (IR) plays a pivotal role. Cinnamon is a herbal medicine with insulinotropic properties. This pilot study aimed to evaluate the effects of cinnamon on ovarian volume, androgenic profile, and metabolic and anthropometric parameters in women with PCOS.
Materials and methods: A single-center, double-blind, randomized, placebo-controlled trial was carried out on 39 overweight / obese women with PCOS. For six months, subjects in the cinnamon (500 mg) (n=19) and placebo (n=20) groups were given three capsules daily. Before and after the intervention, the variables were assessed. The data was analyzed using the GraphPad Prism software.
Results: After the intervention, the two intervention and control groups had significant differences in abdominal subcutaneous fat and ovarian volume, but they did not differ significantly in terms of body mass index (BMI). Also, after the intervention, no significant difference was observed between the two groups in terms of lipid profile and the concentration of androgenic biomarkers of insulin resistance.
Conclusion: Cinnamon supplementation improves ovarian volume and subcutaneous abdominal fat but has no effect on anthropometric parameters, lipid profile, insulin resistance, or androgen hormones.
{"title":"Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study.","authors":"Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki","doi":"10.22038/AJP.2023.23357","DOIUrl":"10.22038/AJP.2023.23357","url":null,"abstract":"<p><strong>Objective: </strong>Most polycystic ovary syndrome (PCOS) patients have metabolic abnormalities in which insulin resistance (IR) plays a pivotal role. Cinnamon is a herbal medicine with insulinotropic properties. This pilot study aimed to evaluate the effects of cinnamon on ovarian volume, androgenic profile, and metabolic and anthropometric parameters in women with PCOS.</p><p><strong>Materials and methods: </strong>A single-center, double-blind, randomized, placebo-controlled trial was carried out on 39 overweight / obese women with PCOS. For six months, subjects in the cinnamon (500 mg) (n=19) and placebo (n=20) groups were given three capsules daily. Before and after the intervention, the variables were assessed. The data was analyzed using the GraphPad Prism software.</p><p><strong>Results: </strong>After the intervention, the two intervention and control groups had significant differences in abdominal subcutaneous fat and ovarian volume, but they did not differ significantly in terms of body mass index (BMI). Also, after the intervention, no significant difference was observed between the two groups in terms of lipid profile and the concentration of androgenic biomarkers of insulin resistance.</p><p><strong>Conclusion: </strong>Cinnamon supplementation improves ovarian volume and subcutaneous abdominal fat but has no effect on anthropometric parameters, lipid profile, insulin resistance, or androgen hormones.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fereshteh Zamiri, Hassan Rakhshandeh, Bita Kiafar, Syed Mohammad Naqvi, Maryam Emadzadeh, Sara Fakhraei, Masoud Maleki
Objective: Body hair removal plays an important role in beauty standards, particularly for women. Finding a method that is easy to use, cheap, and can be done without supervision can significantly affect long-term hair reduction and reduce the side effects of hair removal. The present study investigated the impact of a containing 20% broad bean (Vicia faba) extract cream on axillary hair removal.
Materials and methods: Twenty-five female volunteers were randomly divided into A (right axillary intervention - left axillary placebo) and B (right axillary placebo - left axillary intervention). Depending on the group, each person used a cream containing 20% broad bean extract )"The extract made from the seeds and pods of broad beans.") on one side and a placebo on the other twice a day for three months. Volunteers shaved their axillary hairs three days before each visit and took pictures of both sides on the day of the visit with a trichoscope (to check the diameter and thickness of the hairs).
Results: We found a decrease in thickness on the intervention group (the axilla where a cream containing broad bean extract was applied); however, this difference was not significant between the intervention side and the placebo. In terms of the number of hairs, the difference between the two groups was significant only in the second month despite the decrease on the intervention side. Evaluation based on the personal judgment of the volunteers showed that there was a substantial difference in terms of the number of hairs (p=0.012) and thinning of hair (p=0.02).
Conclusion: Our findings showed that 20% broad bean extract cream could potentially reduce axillary hair growth.
目的体毛脱除在美容标准中扮演着重要角色,尤其是对女性而言。找到一种简单易用、价格低廉、无需监督即可完成的脱毛方法,对长期脱毛和减少脱毛的副作用有重要影响。本研究调查了含有 20% 蚕豆(Vicia faba)提取物的脱毛膏对腋毛脱除的影响:25 名女性志愿者被随机分为 A 组(右腋窝干预-左腋窝安慰剂)和 B 组(右腋窝安慰剂-左腋窝干预)。根据组别不同,每人一侧使用含 20% 蚕豆提取物("从蚕豆种子和豆荚中提取的提取物")的乳膏,另一侧使用安慰剂,每天两次,持续三个月。志愿者在每次就诊前三天剃除腋毛,并在就诊当天用毛囊镜(检查毛发的直径和粗细)拍摄两侧照片:我们发现,干预组(涂抹蚕豆提取物乳膏的腋窝)的毛发厚度有所减少,但干预组与安慰剂组之间的差异并不明显。就毛发数量而言,尽管干预组的毛发数量有所减少,但两组之间的差异仅在第二个月才显著。根据志愿者的个人判断进行的评估显示,在头发数量(p=0.012)和头发稀疏(p=0.02)方面存在显著差异:我们的研究结果表明,20% 的蚕豆提取物乳膏有可能减少腋毛的生长。
{"title":"Assessment of the effects of bean extract on axillary hair reduction.","authors":"Fereshteh Zamiri, Hassan Rakhshandeh, Bita Kiafar, Syed Mohammad Naqvi, Maryam Emadzadeh, Sara Fakhraei, Masoud Maleki","doi":"10.22038/AJP.2023.22888","DOIUrl":"10.22038/AJP.2023.22888","url":null,"abstract":"<p><strong>Objective: </strong>Body hair removal plays an important role in beauty standards, particularly for women. Finding a method that is easy to use, cheap, and can be done without supervision can significantly affect long-term hair reduction and reduce the side effects of hair removal. The present study investigated the impact of a containing 20% broad bean (<i>Vicia faba</i>) extract cream on axillary hair removal.</p><p><strong>Materials and methods: </strong>Twenty-five female volunteers were randomly divided into A (right axillary intervention - left axillary placebo) and B (right axillary placebo - left axillary intervention). Depending on the group, each person used a cream containing 20% broad bean extract )\"The extract made from the seeds and pods of broad beans.\") on one side and a placebo on the other twice a day for three months. Volunteers shaved their axillary hairs three days before each visit and took pictures of both sides on the day of the visit with a trichoscope (to check the diameter and thickness of the hairs).</p><p><strong>Results: </strong>We found a decrease in thickness on the intervention group (the axilla where a cream containing broad bean extract was applied); however, this difference was not significant between the intervention side and the placebo. In terms of the number of hairs, the difference between the two groups was significant only in the second month despite the decrease on the intervention side. Evaluation based on the personal judgment of the volunteers showed that there was a substantial difference in terms of the number of hairs (p=0.012) and thinning of hair (p=0.02).</p><p><strong>Conclusion: </strong>Our findings showed that 20% broad bean extract cream could potentially reduce axillary hair growth.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.
Materials and methods: Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.
Results: RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group.
Conclusion: It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.
目的:本研究探讨了阻力训练(RT)和白藜芦醇(RES)单独或共同对丙烯酰胺(AC)诱导的大鼠记忆损伤的影响:本研究探讨了阻力训练(RT)和白藜芦醇(RES)单独或共同作用对丙烯酰胺(AC)诱导的大鼠记忆损伤的影响:动物分为 6 组:(1)对照组,每天腹腔注射生理盐水,共8周;(2)东莨菪碱组,每天腹腔注射东莨菪碱1毫克/千克,共8周;(3)丙烯酰胺组,每天腹腔注射丙烯酰胺5毫克/千克,共8周;(4)丙烯酰胺+RT组,每天腹腔注射丙烯酰胺5毫克/千克,共8周,同时进行RT训练(每周5天,共8周);(5) AC + RES 组:接受 AC(5 毫克/千克/天,ip)和 RES(1 毫克/千克/天,ip)治疗,共 8 周;以及 (6) AC + RT + RES 组:接受 AC(5 毫克/千克/天,ip)和 RES(1 毫克/千克/天,ip)治疗,共 8 周,并进行 RT(每周 5 天,共 8 周)。第53天,动物开始接受莫里斯水迷宫(MWM)训练,最后一次训练24小时后,进行探针测试:结果:单独的RT和RES对AC增加的逃逸潜伏期和行进距离没有明显影响。然而,与 AC 组相比,同时使用 RES 和 RT 治疗可显著降低这些参数。与交流组相比,RES和RT联合治疗还能显著增加在目标象限停留的时间。与 AC 组相比,AC+RES 组和 AC+RT+RES 组的脂质过氧化程度降低:结论:每天同时使用 RES 和 RT 治疗 8 周似乎可以改善 AC 对记忆的损害。
{"title":"Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.","authors":"Shaghayegh Hemat Jouy, Jafar Shahraki, Ramin Rezaee, Vahideh Ghorani, Mandana Gholami","doi":"10.22038/AJP.2023.22937","DOIUrl":"10.22038/AJP.2023.22937","url":null,"abstract":"<p><strong>Objective: </strong>The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.</p><p><strong>Materials and methods: </strong>Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.</p><p><strong>Results: </strong>RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group.</p><p><strong>Conclusion: </strong>It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage.
Materials and methods: Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined.
Results: Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups.
Conclusion: C. longa ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity.
目的:莪术(CLR)具有强效的抗氧化植物化学成分,研究其对双酚 A(BPA)诱导的心血管和肾脏损伤的影响:随机选取 60 只大鼠,按对照组、双酚 A(100 毫克/千克)组、双酚 A 和 CLR 100 毫克/千克组、双酚 A 和 CLR 200 毫克/千克组、CLR 100 毫克/千克组和 CLR 200 毫克/千克组进行分组,连续 21 天。对氧化应激指数、抗氧化状态、血压参数、遗传毒性和免疫组织化学进行了测定:结果:与服用 CLR 的大鼠相比,暴露于双酚 A 毒性效应的大鼠血压升高,微核多染红细胞频率降低,抗氧化酶活性降低。此外,服用 CLR 能显著(p长春花通过减轻氧化应激、高血压和基因毒性,改善了双酚 A 的心脏毒性和肾毒性作用。
{"title":"Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by <i>Curcuma longa</i> in rats.","authors":"Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Israel Mark Osawere, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Odunayo Ibraheem Azeez, Ayobami Deborah Obisesan, Ademola Adetokunbo Oyagbemi, Olufunke Eunice Ola-Davies, Temidayo Olutayo Omobowale, Adebowale Benard Saba, Adeolu Alex Adedapo, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju","doi":"10.22038/AJP.2023.23367","DOIUrl":"10.22038/AJP.2023.23367","url":null,"abstract":"<p><strong>Objective: </strong><i>Curcuma longa</i> Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage.</p><p><strong>Materials and methods: </strong>Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined.</p><p><strong>Results: </strong>Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups.</p><p><strong>Conclusion: </strong><i>C. longa</i> ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The article studies how Melissa officinalis L. extract and rosmarinic acid (RA) affect lung inflammation, pathology, and oxidative stress in rats with ovalbumin-induced asthma.
Materials and methods: Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received M. officinalis extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.
Results: In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).
Conclusion: This study showed that M. officinalis and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.
目的:文章研究了香蜂草提取物和迷迭香酸(RA)如何影响卵清蛋白诱导的哮喘大鼠的肺部炎症、病理和氧化应激:采用卵清蛋白注射和吸入法诱导大鼠哮喘。研究评估了对照组、未治疗的哮喘大鼠和三个治疗组的肺部炎症、病理变化和氧化应激。这些组分别接受了欧当归提取物(50、100、200 毫克/千克)、RA(0.5、1、2 毫克/千克)或地塞米松(Dex)1 毫克/千克的治疗:结果:在致敏组中,白细胞计数、丙二醛和亚硝酸盐水平显著升高,而硫醇水平以及超氧化物歧化酶和过氧化氢酶的活性降低(pConclusion):本研究表明,M. officinalis 和 RA 在动物哮喘模型中具有抗氧化和抗炎作用,这表明它们具有治疗哮喘症状的潜力。
{"title":"The therapeutic potential of <i>Melissa officinalis</i> L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: A study on anti-inflammatory and antioxidant effects.","authors":"Vahideh Abbasnia, Delaram Eslimi Esfahani, Mohammad Reza Khazdair, Shahrbanoo Oryan, Mohsen Foadoddini","doi":"10.22038/AJP.2023.23321","DOIUrl":"10.22038/AJP.2023.23321","url":null,"abstract":"<p><strong>Objective: </strong>The article studies how <i>Melissa officinalis</i> L. extract and rosmarinic acid (RA) affect lung inflammation, pathology, and oxidative stress in rats with ovalbumin-induced asthma.</p><p><strong>Materials and methods: </strong>Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received <i>M. officinalis</i> extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.</p><p><strong>Results: </strong>In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).</p><p><strong>Conclusion: </strong>This study showed that <i>M. officinalis</i> and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Silibinin has exhibited antitumor activities. However, there are few reports about the immunomodulatory properties of silibinin on T lymphocyte function in the tumor microenvironment. Here, we determined the effects of silibinin on T cells of peripheral blood mononuclear cells (PBMCs), cultivated alone or with a human cell line of glioblastoma (U-87 MG).
Materials and methods: The proliferation of T lymphocytes was assessed by MTT test in the presence of silibinin (15 and 45 µM). Also, total antioxidant capacity (TAC), the activity of superoxide dismutase-3 (SOD3), and the levels of two cytokines interferon gamma (IFN-γ) and tumor growth beta (TGF-β) were compared between treated and untreated PBMCs alone or co-cultured with U-87 cells.
Results: According to our results, silibinin raised the TAC levels and SOD3 activity in the PBMCs and in the co-culture condition. Moreover, silibinin-treated PBMCs showed higher IFN-γ levels and lower TGF-β levels. Interestingly, silibinin protected PBMCs against the U-87-induced suppression.
Conclusion: Altogether, these results proposed the immunomodulatory potential of silibinin on T cells of PBMCs, as well as its partially protective effects on PBMCs against the suppression induced by U-87 MG cells.
{"title":"Silibinin improved the function of T cells in peripheral blood mononuclear cells (PBMCs) co-cultured with U-87 MG cell line.","authors":"Banafshe Abadi, Jahangir Abdesheikhi, Farnaz Sedghy, Merat Mahmoodi, Hossein Fallah","doi":"10.22038/AJP.2023.22935","DOIUrl":"10.22038/AJP.2023.22935","url":null,"abstract":"<p><strong>Objective: </strong>Silibinin has exhibited antitumor activities. However, there are few reports about the immunomodulatory properties of silibinin on T lymphocyte function in the tumor microenvironment. Here, we determined the effects of silibinin on T cells of peripheral blood mononuclear cells (PBMCs), cultivated alone or with a human cell line of glioblastoma (U-87 MG).</p><p><strong>Materials and methods: </strong>The proliferation of T lymphocytes was assessed by MTT test in the presence of silibinin (15 and 45 µM). Also, total antioxidant capacity (TAC), the activity of superoxide dismutase-3 (SOD3), and the levels of two cytokines interferon gamma (IFN-γ) and tumor growth beta (TGF-β) were compared between treated and untreated PBMCs alone or co-cultured with U-87 cells.</p><p><strong>Results: </strong>According to our results, silibinin raised the TAC levels and SOD3 activity in the PBMCs and in the co-culture condition. Moreover, silibinin-treated PBMCs showed higher IFN-γ levels and lower TGF-β levels. Interestingly, silibinin protected PBMCs against the U-87-induced suppression.</p><p><strong>Conclusion: </strong>Altogether, these results proposed the immunomodulatory potential of silibinin on T cells of PBMCs, as well as its partially protective effects on PBMCs against the suppression induced by U-87 MG cells.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azadeh Zareie, Mohammad Bagherniya, Amirhossein Sahebkar, Manoj Sharma, Fariborz Khorvash, Akbar Hasanzadeh, Gholamreza Askari
Objective: Increased body mass index (BMI) seems to be a risk factor for migraine attacks. Cinnamon has anti-inflammatory, neuroprotective, and anti-obesity effects. This study aimed to assess the effects of cinnamon on anthropometric indices and headache-related disability of patients with migraine.
Materials and methods: This study was conducted as a randomized, double-blind, placebo-controlled trial involving 50 migraine patients. Patients were randomized to receive either 600 mg cinnamon powder or placebo capsules for two months. Height, body weight (BW), waist circumference (WC), and hip circumference (HC) were measured.Furthermore, Minimal or Infrequent Disability (MIDAS) and Headache Daily Result (HDR) Questionnaires were recorded.
Results: At the end of the treatment period, BW and BMI did not change in the intervention group; however, both factors were significantly increased in the placebo group (p=0.001). The change of WC, HDR and MIDAS was significantly different between the intervention and placebo groups (p<0.001). Furthermore, HC and WHR significantly decreased (p=0.001).
Conclusion: Cinnamon seems to have beneficial effects on anthropometric indices and headache disability of migraine patients.
{"title":"Effects of cinnamon on anthropometric indices and headache-related disability of patients with migraine: A randomized double-blind placebo-controlled trial.","authors":"Azadeh Zareie, Mohammad Bagherniya, Amirhossein Sahebkar, Manoj Sharma, Fariborz Khorvash, Akbar Hasanzadeh, Gholamreza Askari","doi":"10.22038/AJP.2023.22874","DOIUrl":"10.22038/AJP.2023.22874","url":null,"abstract":"<p><strong>Objective: </strong>Increased body mass index (BMI) seems to be a risk factor for migraine attacks. Cinnamon has anti-inflammatory, neuroprotective, and anti-obesity effects. This study aimed to assess the effects of cinnamon on anthropometric indices and headache-related disability of patients with migraine.</p><p><strong>Materials and methods: </strong>This study was conducted as a randomized, double-blind, placebo-controlled trial involving 50 migraine patients. Patients were randomized to receive either 600 mg cinnamon powder or placebo capsules for two months. Height, body weight (BW), waist circumference (WC), and hip circumference (HC) were measured.Furthermore, Minimal or Infrequent Disability (MIDAS) and Headache Daily Result (HDR) Questionnaires were recorded.</p><p><strong>Results: </strong>At the end of the treatment period, BW and BMI did not change in the intervention group; however, both factors were significantly increased in the placebo group (p=0.001). The change of WC, HDR and MIDAS was significantly different between the intervention and placebo groups (p<0.001). Furthermore, HC and WHR significantly decreased (p=0.001).</p><p><strong>Conclusion: </strong>Cinnamon seems to have beneficial effects on anthropometric indices and headache disability of migraine patients.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}