Pub Date : 2023-03-31DOI: 10.20473/bikk.v35.1.2023.46-51
Ervina Rosmarwati, N. Mulianto
Background: Decubitus ulcer is an area of necrotic tissue due to compression of protrusion because of prolonged immobilization. Decubitus ulcer is complication that often occur due to prolonged bed rest. Decubitus ulcer can interfere with patient’s recovery process and prolonged hospital stay. Purpose: To investigate profile of decubitus ulcer in hospitalized patients in Dr. Moewardi General Hospital Surakarta during 2017- 2020. Methods: This descriptive retrospective study was conducted by using medical record of decubitus ulcers (ICD 10 L89.0, L89.1, L89.2, L89.3) in Dr. Moewardi General Hospital Surakarta during 1st January 2017-31st December 2020. Result: There were 375 decubitus ulcer patients, mostly aged 70 years or more (29.1%) and dominated by women (56%). Patients with decubitus ulcers often hospitalized in the regular ward (75.2%) with the longest length of stay being around 0-10 days (49.6%) and the most common comorbidities was malignancy (20.5%). Systemic antibiotic ceftriaxone was most often given to decubitus ulcer patients (21.6%). Most of the patients with decubitus ulcers had stage 2 decubitus ulcers (53.6%) with a predisposition to the affected area being the sacrum area (33%). The most frequently used therapy for decubitus ulcers was hydrogel dressing (33.9%). Conclusion: Decubitus ulcers are often found in patients over 70 years of age with comorbid malignancies. The most common diagnosis was stage 2 decubitus ulcers, predisposing to the sacral region and the most frequently used therapy was hydrogel dressing with ceftriaxone as a systemic antibiotic.
{"title":"Retrospective Study of Decubitus Ulcer in Hospitalized Patients","authors":"Ervina Rosmarwati, N. Mulianto","doi":"10.20473/bikk.v35.1.2023.46-51","DOIUrl":"https://doi.org/10.20473/bikk.v35.1.2023.46-51","url":null,"abstract":"Background: Decubitus ulcer is an area of necrotic tissue due to compression of protrusion because of prolonged immobilization. Decubitus ulcer is complication that often occur due to prolonged bed rest. Decubitus ulcer can interfere with patient’s recovery process and prolonged hospital stay. Purpose: To investigate profile of decubitus ulcer in hospitalized patients in Dr. Moewardi General Hospital Surakarta during 2017- 2020. Methods: This descriptive retrospective study was conducted by using medical record of decubitus ulcers (ICD 10 L89.0, L89.1, L89.2, L89.3) in Dr. Moewardi General Hospital Surakarta during 1st January 2017-31st December 2020. Result: There were 375 decubitus ulcer patients, mostly aged 70 years or more (29.1%) and dominated by women (56%). Patients with decubitus ulcers often hospitalized in the regular ward (75.2%) with the longest length of stay being around 0-10 days (49.6%) and the most common comorbidities was malignancy (20.5%). Systemic antibiotic ceftriaxone was most often given to decubitus ulcer patients (21.6%). Most of the patients with decubitus ulcers had stage 2 decubitus ulcers (53.6%) with a predisposition to the affected area being the sacrum area (33%). The most frequently used therapy for decubitus ulcers was hydrogel dressing (33.9%). Conclusion: Decubitus ulcers are often found in patients over 70 years of age with comorbid malignancies. The most common diagnosis was stage 2 decubitus ulcers, predisposing to the sacral region and the most frequently used therapy was hydrogel dressing with ceftriaxone as a systemic antibiotic.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80098044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.20473/bikk.v35.1.2023.21-26
Sawitri, Arisia Fadila, M. Yulianto Listiawan, Priangga Adi Wiratama, Dwi Murtiastutik, Evy Ervianti, Linda Astari, Damayanti, Diah Mira Indramaya, Afif Nurul Hidayati, Medhi Denisa Alinda
Background: Psoriasis vulgaris can be diagnosed clinically. A biopsy is usually used to confirm non-classic cases. The findings of the histopathology feature are not usually present, thus clinical relevance is needed to confirm the diagnosis. Purpose: To describe the histopathology findings from tissue samples of histopathologically confirmed psoriasis vulgaris reported in the Department of Pathology and Anatomy of Dr. Soetomo General Hospital. Methods: A descriptive-retrospective study of pathology-ascertained tissue samples of histopathologically confirmed psoriasis vulgaris was reported in the Department of Pathology and Anatomy from patients who were also previously diagnosed clinically with psoriasis vulgaris in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital over a period of 2 years. Morphological parameters were observed after histopathology sections were stained with hematoxylin and eosin. Result: Thirty-three tissue samples were examined. Parakeratosis (86%) and hypogranulosis (70.3%) were the most observed findings. Club-shaped rete ridges, suprapapillary plate thinning, and spongiform pustules of Kogoj were the least observed findings (each by 2.7%). Three tissue samples (8.1%) showed only parakeratosis. Only 1 tissue sample (2.7%) showed 4 features (absence of the granular layer, parakeratosis, microabscess of Munro, and spongiform pustules of Kogoj). No tissue sample showed every histopathology finding of psoriasis vulgaris. Conclusion: All of the histopathology features of psoriasis vulgaris are rarely found in one tissue section. Albeit histopathology is believed to be the gold standard diagnosis of psoriasis vulgaris, relevance with clinical findings is still mandatory to support the diagnosis.
{"title":"Evaluation of Histopathology Findings of Clinically Confirmed Psoriasis Vulgaris","authors":"Sawitri, Arisia Fadila, M. Yulianto Listiawan, Priangga Adi Wiratama, Dwi Murtiastutik, Evy Ervianti, Linda Astari, Damayanti, Diah Mira Indramaya, Afif Nurul Hidayati, Medhi Denisa Alinda","doi":"10.20473/bikk.v35.1.2023.21-26","DOIUrl":"https://doi.org/10.20473/bikk.v35.1.2023.21-26","url":null,"abstract":"Background: Psoriasis vulgaris can be diagnosed clinically. A biopsy is usually used to confirm non-classic cases. The findings of the histopathology feature are not usually present, thus clinical relevance is needed to confirm the diagnosis. Purpose: To describe the histopathology findings from tissue samples of histopathologically confirmed psoriasis vulgaris reported in the Department of Pathology and Anatomy of Dr. Soetomo General Hospital. Methods: A descriptive-retrospective study of pathology-ascertained tissue samples of histopathologically confirmed psoriasis vulgaris was reported in the Department of Pathology and Anatomy from patients who were also previously diagnosed clinically with psoriasis vulgaris in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital over a period of 2 years. Morphological parameters were observed after histopathology sections were stained with hematoxylin and eosin. Result: Thirty-three tissue samples were examined. Parakeratosis (86%) and hypogranulosis (70.3%) were the most observed findings. Club-shaped rete ridges, suprapapillary plate thinning, and spongiform pustules of Kogoj were the least observed findings (each by 2.7%). Three tissue samples (8.1%) showed only parakeratosis. Only 1 tissue sample (2.7%) showed 4 features (absence of the granular layer, parakeratosis, microabscess of Munro, and spongiform pustules of Kogoj). No tissue sample showed every histopathology finding of psoriasis vulgaris. Conclusion: All of the histopathology features of psoriasis vulgaris are rarely found in one tissue section. Albeit histopathology is believed to be the gold standard diagnosis of psoriasis vulgaris, relevance with clinical findings is still mandatory to support the diagnosis.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75686437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.20473/bikk.v35.1.2023.15-20
Anasya Putri Ramadhina, T. Setyaningrum, Artaria Tjempakasari, Damayanti
Background: Vitiligo is an idiopathic disease with a prevalence of 0.5-2% worldwide that causes the loss of melanocyte cells from parts of the body and is characterized by the appearance of well-defined white macules. The pathogenesis of vitiligo is suspected to originate from genetic, non-genetic, and autoimmune factors. Currently, Narrowband Ultraviolet-B (NB-UVB) is the first-line phototherapy treatment to treat vitiligo. Purpose: To evaluate the profile of vitiligo patients who were given phototherapy at the Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Academic Hospital for the period January-December 2019. Methods: This study used a retrospective descriptive research design with descriptive statistical methods. In this study, the medical records were evaluated by recording the patient's age, gender, occupation, history of illness, family history, and results of a physical examination. Result: This study obtained 31 samples that received phototherapy dominated by the age range of 17-25 years (29%) and male gender (55%), with a ratio of 1:0.82 to women. The majority work as others (68%). The most common trigger factor was emotional stress (29%). According to physical examination, the majority of patients had multiple lesions (81%), were not widely available (58%), and were of the generalized type (52%). Conclusion: It can be evaluated from the most data obtained: 17-25 years old (29%), male gender (55%), other occupations (68%), emotional stress triggers (29%), multiple lesions (81%), unavailable lesion area (58%), and generalized type (52%), describe the profile of vitiligo patients in Dr. Seotomo General Academic Hospital in 2019.
{"title":"Clinico-Epidemiological Profile of Vitiligo Patients Receiving Narrowband Ultraviolet-B (NB-UVB) Treatment","authors":"Anasya Putri Ramadhina, T. Setyaningrum, Artaria Tjempakasari, Damayanti","doi":"10.20473/bikk.v35.1.2023.15-20","DOIUrl":"https://doi.org/10.20473/bikk.v35.1.2023.15-20","url":null,"abstract":"Background: Vitiligo is an idiopathic disease with a prevalence of 0.5-2% worldwide that causes the loss of melanocyte cells from parts of the body and is characterized by the appearance of well-defined white macules. The pathogenesis of vitiligo is suspected to originate from genetic, non-genetic, and autoimmune factors. Currently, Narrowband Ultraviolet-B (NB-UVB) is the first-line phototherapy treatment to treat vitiligo. Purpose: To evaluate the profile of vitiligo patients who were given phototherapy at the Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Academic Hospital for the period January-December 2019. Methods: This study used a retrospective descriptive research design with descriptive statistical methods. In this study, the medical records were evaluated by recording the patient's age, gender, occupation, history of illness, family history, and results of a physical examination. Result: This study obtained 31 samples that received phototherapy dominated by the age range of 17-25 years (29%) and male gender (55%), with a ratio of 1:0.82 to women. The majority work as others (68%). The most common trigger factor was emotional stress (29%). According to physical examination, the majority of patients had multiple lesions (81%), were not widely available (58%), and were of the generalized type (52%). Conclusion: It can be evaluated from the most data obtained: 17-25 years old (29%), male gender (55%), other occupations (68%), emotional stress triggers (29%), multiple lesions (81%), unavailable lesion area (58%), and generalized type (52%), describe the profile of vitiligo patients in Dr. Seotomo General Academic Hospital in 2019.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88377492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.20473/bikk.v35.1.2023.57-66
Nurvania aurellia Budirahmadina, D. S. Perdanakusuma, Evy Ervianti, Iswinarno doso Saputra
Background: Wounds that have lasted a long time due to failure to continue the normal healing process can be called chronic wounds. Chronic wounds occur due to multiple factors. There are problems that are often found in chronic wounds, such as the presence of exudate, necrotic tissue, and bacteria. The incidence of chronic wounds is closely related to the high cost of treatment and impaired quality of life. Prompt wound management is needed to optimize wound healing. Purpose: To determine the profile of chronic wounds in patients treated by the Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from 2015 – 2020. Methods: The data were obtained from patients medical records through total sampling technique, which consist of age, gender, past medical history, clinical features, diagnosis, management, and outcome. Result: This study involved 53 patients, dominated by male patients (70%) aged 46-65 years old (34%). The patient’s history showed that most patients suffered from type 2 diabetes (22%). The problem that often occurs is the presence of exudate which is mostly diagnosed with pressure ulcers (40%). All patient get wound bed preparation and the patient's outcome was dominated by recovery (72%). Conclusion: There are several factors affecting wound healing and prompt wound management are important to improving the outcomes.
{"title":"The Clinical Profile of Patients with Chronic Wounds at Dr. Soetomo General Hospital 2015-2020","authors":"Nurvania aurellia Budirahmadina, D. S. Perdanakusuma, Evy Ervianti, Iswinarno doso Saputra","doi":"10.20473/bikk.v35.1.2023.57-66","DOIUrl":"https://doi.org/10.20473/bikk.v35.1.2023.57-66","url":null,"abstract":"Background: Wounds that have lasted a long time due to failure to continue the normal healing process can be called chronic wounds. Chronic wounds occur due to multiple factors. There are problems that are often found in chronic wounds, such as the presence of exudate, necrotic tissue, and bacteria. The incidence of chronic wounds is closely related to the high cost of treatment and impaired quality of life. Prompt wound management is needed to optimize wound healing. Purpose: To determine the profile of chronic wounds in patients treated by the Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from 2015 – 2020. Methods: The data were obtained from patients medical records through total sampling technique, which consist of age, gender, past medical history, clinical features, diagnosis, management, and outcome. Result: This study involved 53 patients, dominated by male patients (70%) aged 46-65 years old (34%). The patient’s history showed that most patients suffered from type 2 diabetes (22%). The problem that often occurs is the presence of exudate which is mostly diagnosed with pressure ulcers (40%). All patient get wound bed preparation and the patient's outcome was dominated by recovery (72%). Conclusion: There are several factors affecting wound healing and prompt wound management are important to improving the outcomes.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73902308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: World Health Organization (WHO) reported that there are 6 million new cases of syphilis worldwide per year. The incidence of syphilis in Indonesia has increased over the past few years, particularly among men who have sex with men (MSM). Purpose: To report a case of secondary syphilis with Human Immunodeficiency Virus (HIV) coinfection in MSM, thereby increasing understanding of high-risk sexual behavior among MSM. Case: A 26-year-old man with a chief complaint of rashes on both palms, soles of the feet, and face. The rashes spread with no itching, heat, or pain, which occurred two weeks ago. The patient was diagnosed with HIV in 2019. Physical examination found multiple violaceus macules with clear boundaries, 0.5–1 cm in size, covered with scales. Venereal Disease Research Laboratory (VDRL) serology titer was 1:16 and Treponema Pallidum Haemagglutination Assay (TPHA) was 1:20.480. The recent CD4 count was 440 with an undetectable HIV RNA viral load. Benzathine penicillin G 2.4 million units was given intramuscularly 3 times at 1-week intervals. The patient experienced clinical improvement and decreased VDRL and TPHA titers. Discussion: Syphilis patients with or without HIV would have similar clinical symptoms. However, syphilis patients with HIV tend to have more extensive lesions. The treatment option with three doses of benzathine penicillin G is still very effective in cases of syphilis with HIV. Conclusion: Syphilis has a higher incidence in MSM patients with extensive clinical manifestations of skin lesions. It can be observed in syphilis patients with HIV; therefore, close monitoring is needed.
{"title":"Secondary Syphilis and Human Immunodeficiency Virus (HIV) Co-infection in Men Who Have Sex with Men (MSM) with Triple Doses Benzathine Penicillin G Treatment: A Case Report","authors":"Olivia awwalin Sunarto, Sulaksanaswastho Suyoso, Prasti Adhi Dharmasant","doi":"10.20473/bikk.v35.1.2023.81-87","DOIUrl":"https://doi.org/10.20473/bikk.v35.1.2023.81-87","url":null,"abstract":"Background: World Health Organization (WHO) reported that there are 6 million new cases of syphilis worldwide per year. The incidence of syphilis in Indonesia has increased over the past few years, particularly among men who have sex with men (MSM). Purpose: To report a case of secondary syphilis with Human Immunodeficiency Virus (HIV) coinfection in MSM, thereby increasing understanding of high-risk sexual behavior among MSM. Case: A 26-year-old man with a chief complaint of rashes on both palms, soles of the feet, and face. The rashes spread with no itching, heat, or pain, which occurred two weeks ago. The patient was diagnosed with HIV in 2019. Physical examination found multiple violaceus macules with clear boundaries, 0.5–1 cm in size, covered with scales. Venereal Disease Research Laboratory (VDRL) serology titer was 1:16 and Treponema Pallidum Haemagglutination Assay (TPHA) was 1:20.480. The recent CD4 count was 440 with an undetectable HIV RNA viral load. Benzathine penicillin G 2.4 million units was given intramuscularly 3 times at 1-week intervals. The patient experienced clinical improvement and decreased VDRL and TPHA titers. Discussion: Syphilis patients with or without HIV would have similar clinical symptoms. However, syphilis patients with HIV tend to have more extensive lesions. The treatment option with three doses of benzathine penicillin G is still very effective in cases of syphilis with HIV. Conclusion: Syphilis has a higher incidence in MSM patients with extensive clinical manifestations of skin lesions. It can be observed in syphilis patients with HIV; therefore, close monitoring is needed.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88259945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.20473/bikk.v34.3.2022.197-202
P. Mawardi, Danu Yuliarto
Background: Condyloma acuminatum (CA) or genital warts are sexually transmitted infections caused by human papillomavirus (HPV). It is estimated that CA occurs in >80% of reproductive age in many countries, with the most common subtypes being 6 and 11. Purpose: The aim of the study to reveal the high risk (HR)-HPV in various condyloma acuminata in Dr. Moewardi Hospital. Methods: This study was a cross-sectional analytical observational study that assessed data collection concurrently over time. Specimens were patients diagnosed with condyloma acuminatum, biopsies were performed, and immunohistochemical staining was also performed. The sampling technique used sequential sampling, and the inclusion criteria included patients who came to our hospital for treatment. Results: The majority of the male sample was MSM. According to HIV status, 6 (30%) male patients were found to be positive. Immunohistochemistry showed that 15% of the samples were HR-HPV. Statistical test results for HR-HPV and low-risk (LR) HPV were significant, p-value = 0.038. Conclusion: Condyloma acuminatum is a sexually transmitted infection that usually occurs at the same time as HIV infection. In our study all patients with HR-HPV were MSM.
{"title":"Susceptibility of Male who Have Sex with Male to High-Risk Type Human Papillomavirus (HPV) 16 and 18 with Condyloma Acuminata","authors":"P. Mawardi, Danu Yuliarto","doi":"10.20473/bikk.v34.3.2022.197-202","DOIUrl":"https://doi.org/10.20473/bikk.v34.3.2022.197-202","url":null,"abstract":"Background: Condyloma acuminatum (CA) or genital warts are sexually transmitted infections caused by human papillomavirus (HPV). It is estimated that CA occurs in >80% of reproductive age in many countries, with the most common subtypes being 6 and 11. Purpose: The aim of the study to reveal the high risk (HR)-HPV in various condyloma acuminata in Dr. Moewardi Hospital. Methods: This study was a cross-sectional analytical observational study that assessed data collection concurrently over time. Specimens were patients diagnosed with condyloma acuminatum, biopsies were performed, and immunohistochemical staining was also performed. The sampling technique used sequential sampling, and the inclusion criteria included patients who came to our hospital for treatment. Results: The majority of the male sample was MSM. According to HIV status, 6 (30%) male patients were found to be positive. Immunohistochemistry showed that 15% of the samples were HR-HPV. Statistical test results for HR-HPV and low-risk (LR) HPV were significant, p-value = 0.038. Conclusion: Condyloma acuminatum is a sexually transmitted infection that usually occurs at the same time as HIV infection. In our study all patients with HR-HPV were MSM.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85260199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.20473/bikk.v34.3.2022.162-168
Emma Hidayati Sasmito, A. Hidayati, Rahmadewi, Sawitri, Budi Utomo, Sudjarwo, Pepy Dwi Endraswari, Diah Mira Indaramaya, Dwi Murtiastutik
Background: Oral candidiasis is an infection caused by Candida sp. in areas of the oral mucosa that are often found in HIV/AIDS patients. Increased antifungal resistance, it was important to find new antifungal candidates, especially from natural ingredients, basil leaf extract (Ocimum sanctum Linn.) which had major compound of eugenol that had an antifungal effect in inhibiting of Candida sp. Purpose: To evaluate the comparison of the antifungal susceptibility of nystatin, basil leaf extract (Ocimum sanctum Linn.) and eugenol against isolates of Candida sp. Methods: This study examined the comparison of the antifungal susceptibility of nystatin 100 IU, basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol, and eugenol 800 µg/mL and 400 µg/mL against 40 stored isolates of Candida sp. from the oral cavity of HIV/AIDS patient which was reactivated. Result: The mean inhibition zone of nystatin for all isolates was 22.98 mm, while the mean inhibition zone of eugenol with doses of 800 µg/mL and 400 µg/mL were 17.07 mm and 15.89 mm, and the mean inhibition zone of basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol are 14.87 mm and 14.01 mm. The inhibition zone of basil leaf extract (Ocimum sanctum Linn.) and eugenol was significantly lower than nystatin (p = 0.001; p < 0.05). Conclusion: The zone of inhibition of nystatin was significantly higher compared to basil leaf extract (Ocimum sanctum Linn.) and eugenol against Candida albicans and Candida non-albicans isolates.
{"title":"Comparison of Antifungal Susceptibility Basil Leaves Extract (Ocimum sanctum Linn.), Eugenol, and Nystatin against Isolates of Candida spp. as Important Agent causing Oral Candidiasis in HIV/AIDS Patient","authors":"Emma Hidayati Sasmito, A. Hidayati, Rahmadewi, Sawitri, Budi Utomo, Sudjarwo, Pepy Dwi Endraswari, Diah Mira Indaramaya, Dwi Murtiastutik","doi":"10.20473/bikk.v34.3.2022.162-168","DOIUrl":"https://doi.org/10.20473/bikk.v34.3.2022.162-168","url":null,"abstract":"Background: Oral candidiasis is an infection caused by Candida sp. in areas of the oral mucosa that are often found in HIV/AIDS patients. Increased antifungal resistance, it was important to find new antifungal candidates, especially from natural ingredients, basil leaf extract (Ocimum sanctum Linn.) which had major compound of eugenol that had an antifungal effect in inhibiting of Candida sp.\u0000Purpose: To evaluate the comparison of the antifungal susceptibility of nystatin, basil leaf extract (Ocimum sanctum Linn.) and eugenol against isolates of Candida sp.\u0000Methods: This study examined the comparison of the antifungal susceptibility of nystatin 100 IU, basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol, and eugenol 800 µg/mL and 400 µg/mL against 40 stored isolates of Candida sp. from the oral cavity of HIV/AIDS patient which was reactivated.\u0000Result: The mean inhibition zone of nystatin for all isolates was 22.98 mm, while the mean inhibition zone of eugenol with doses of 800 µg/mL and 400 µg/mL were 17.07 mm and 15.89 mm, and the mean inhibition zone of basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol are 14.87 mm and 14.01 mm. The inhibition zone of basil leaf extract (Ocimum sanctum Linn.) and eugenol was significantly lower than nystatin (p = 0.001; p < 0.05).\u0000Conclusion: The zone of inhibition of nystatin was significantly higher compared to basil leaf extract (Ocimum sanctum Linn.) and eugenol against Candida albicans and Candida non-albicans isolates.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80616140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.20473/bikk.v34.3.2022.178-183
I. Purnamasari, Evy Ervianti, D. Damayanti, Budi Prasetyo, L. Astari, Pepy D. Endraswari, M. Listiawan, C. Prakoeswa
Background: Vulvovaginal candidiasis (VVC) is one of the most prevalent genital tract diseases in women. The identification of the isolated Candida species is critical for guiding empirical antifungal therapy. Purpose: To determine the Candida species that cause vulvovaginal candidiasis in pregnancy at the Obstetrics and Gynecology Outpatient Clinic, Dr. Soetomo General Academic Hospital, thus providing scientific and therapeutic benefits. Methods: Pregnant woman receiving antenatal care (ANC) at Dr. Soetomo General Academic Hospital Obstetric and Gynecology Outpatient Clinic. Subjects were enrolled in a cross-sectional study during 3 months between March and May 2021. Vaginal swab samples were taken from subjects after informed consent. A specific color change in CHROMagar cultures and VITEK 2 compact were used to identify Candida species. Result: During the study period, 15 pregnant patients were diagnosed with VVC. The majority of the women in the study were pregnant women of sexually active age who complained of a whitish body and genital irritation. There were 18 candida isolates from CHROMagar cultures, with C. non albicans (61.1%) predominating over C. albicans (38.3%). With details, non albicans were C. glabrata (54.4%), C. dubliniensis (36.3%), and C. parapsilosis (18.1%). Conclusion: This study revealed a high prevalence of Candida non-albicans species causing VVC. Culture investigation and identification of Candida are critical to avoid diminished susceptibility to antifungal treatments and recurrence.
{"title":"Pattern of Candida Species Isolated from Patient with Vulvovaginal Candidiasis in Pregnancy","authors":"I. Purnamasari, Evy Ervianti, D. Damayanti, Budi Prasetyo, L. Astari, Pepy D. Endraswari, M. Listiawan, C. Prakoeswa","doi":"10.20473/bikk.v34.3.2022.178-183","DOIUrl":"https://doi.org/10.20473/bikk.v34.3.2022.178-183","url":null,"abstract":"Background: Vulvovaginal candidiasis (VVC) is one of the most prevalent genital tract diseases in women. The identification of the isolated Candida species is critical for guiding empirical antifungal therapy. Purpose: To determine the Candida species that cause vulvovaginal candidiasis in pregnancy at the Obstetrics and Gynecology Outpatient Clinic, Dr. Soetomo General Academic Hospital, thus providing scientific and therapeutic benefits. Methods: Pregnant woman receiving antenatal care (ANC) at Dr. Soetomo General Academic Hospital Obstetric and Gynecology Outpatient Clinic. Subjects were enrolled in a cross-sectional study during 3 months between March and May 2021. Vaginal swab samples were taken from subjects after informed consent. A specific color change in CHROMagar cultures and VITEK 2 compact were used to identify Candida species. Result: During the study period, 15 pregnant patients were diagnosed with VVC. The majority of the women in the study were pregnant women of sexually active age who complained of a whitish body and genital irritation. There were 18 candida isolates from CHROMagar cultures, with C. non albicans (61.1%) predominating over C. albicans (38.3%). With details, non albicans were C. glabrata (54.4%), C. dubliniensis (36.3%), and C. parapsilosis (18.1%). Conclusion: This study revealed a high prevalence of Candida non-albicans species causing VVC. Culture investigation and identification of Candida are critical to avoid diminished susceptibility to antifungal treatments and recurrence.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"931 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77552674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.20473/bikk.v34.3.2022.174-177
Damayanti, Astindari, Trisiswati Indranarum, Hasnikmah Mappamasing, Farsha Naufal Hadiwidjaja, P. G. Axelia
Background: Xerosis cutis presents in more than 50% of the elderly population and is currently the most common complaint related to a skin condition in the elderly population. However, many of them are still uninformed of this complaint. Education plays an important role in the management of xerosis cutis, such as how to identify and avoid triggering factors and how to break the itch-scratch cycle. Purpose: This study aims to evaluate the level of knowledge on xerosis cutis in the elderly population after receiving health education. Methods: This observational study involved 71 subjects who met the inclusion criteria of being elderly and were willing to participate in this study. The data were collected using questionnaires. The level of knowledge was assessed before and after the health education around xerosis cutis. Result: Eleven (15.49%) male and 60 (84.51%) female subjects participated in this study. There was a significant difference mean scores between the pre-test and post-test after health education (p= <0.001). The means of total scores of the pre-test and post-test were 11.72 ± 1.475 and 12.58 ± 1.662. The questionnaire consisted of chapters regarding skin changes in the elderly, risk factors for xerosis cutis, and management of xerosis cutis. A significant difference in score between the pre-test and post-test was found in all the chapters (p=0.046, p=0.002, and p=0.006). Conclusion: Following health education, there was an improvement in the elderly's level of knowledge on xerosis cutis.
{"title":"Knowledge Improvement of Xerosis Cutis through Health Education in the Elderly","authors":"Damayanti, Astindari, Trisiswati Indranarum, Hasnikmah Mappamasing, Farsha Naufal Hadiwidjaja, P. G. Axelia","doi":"10.20473/bikk.v34.3.2022.174-177","DOIUrl":"https://doi.org/10.20473/bikk.v34.3.2022.174-177","url":null,"abstract":"Background: Xerosis cutis presents in more than 50% of the elderly population and is currently the most common complaint related to a skin condition in the elderly population. However, many of them are still uninformed of this complaint. Education plays an important role in the management of xerosis cutis, such as how to identify and avoid triggering factors and how to break the itch-scratch cycle. Purpose: This study aims to evaluate the level of knowledge on xerosis cutis in the elderly population after receiving health education. Methods: This observational study involved 71 subjects who met the inclusion criteria of being elderly and were willing to participate in this study. The data were collected using questionnaires. The level of knowledge was assessed before and after the health education around xerosis cutis. Result: Eleven (15.49%) male and 60 (84.51%) female subjects participated in this study. There was a significant difference mean scores between the pre-test and post-test after health education (p= <0.001). The means of total scores of the pre-test and post-test were 11.72 ± 1.475 and 12.58 ± 1.662. The questionnaire consisted of chapters regarding skin changes in the elderly, risk factors for xerosis cutis, and management of xerosis cutis. A significant difference in score between the pre-test and post-test was found in all the chapters (p=0.046, p=0.002, and p=0.006). Conclusion: Following health education, there was an improvement in the elderly's level of knowledge on xerosis cutis.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82199420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.20473/bikk.v34.3.2022.156-161
M. Listiawan, Farah Meriana Fajrin, R. Rahmadewi, A. Hidayati, S. Sawitri, D. Indramaya, R. Setiabudi, Maya Wardiana
Background: Acne vulgaris (AV) is not a deadly condition may affect one’s quality of life. Treatment of AV includes topical and oral, depending on the severity. Antibiotics as oral treatment should not be given alone because it can precipitate resistance. Purpose: To describe the clinical characteristics of AV in a tertiary hospital in Indonesia and evaluate the treatment given. Methods: This is a descriptive, retrospective study with a cross-sectional design. The study subject was classified based on severity according to Plewig and Kligman’s acne grading. Further evaluation was made according to the type of lesion, the risk factortopical and oral treatment in subjects with grades 2, 3, and 4. This research was conducted at the Cosmetic Medic Division, Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital Surabaya based on medical records from the period of 2017 to 2019. Result: From 2017 to 2019, there were 525 (1.1%) new AV patients out of a total of 45,754 new patients. AV was the major diagnosis in the Cosmetic Medic division. AV grades 2, 3, and 4 were found in 167 patients (32.0%). The most common lesion was papulopustular (75.4%) and the most common risk factor was hormonal (58.7%). All the patients received tretinoin, clindamycin gel 1.2%, and sunscreen for topical treatment. Doxycycline was the most common oral antibiotic used (98.2%) Conclusion: The most common AV grade in this study was mild AV. Oral antibiotics were given to moderate-to-severe AV patients in combination with topical treatment to prevent resistance.
{"title":"Clinical Profile and Treatment of Acne Vulgaris Patients","authors":"M. Listiawan, Farah Meriana Fajrin, R. Rahmadewi, A. Hidayati, S. Sawitri, D. Indramaya, R. Setiabudi, Maya Wardiana","doi":"10.20473/bikk.v34.3.2022.156-161","DOIUrl":"https://doi.org/10.20473/bikk.v34.3.2022.156-161","url":null,"abstract":"Background: Acne vulgaris (AV) is not a deadly condition may affect one’s quality of life. Treatment of AV includes topical and oral, depending on the severity. Antibiotics as oral treatment should not be given alone because it can precipitate resistance. Purpose: To describe the clinical characteristics of AV in a tertiary hospital in Indonesia and evaluate the treatment given. Methods: This is a descriptive, retrospective study with a cross-sectional design. The study subject was classified based on severity according to Plewig and Kligman’s acne grading. Further evaluation was made according to the type of lesion, the risk factortopical and oral treatment in subjects with grades 2, 3, and 4. This research was conducted at the Cosmetic Medic Division, Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital Surabaya based on medical records from the period of 2017 to 2019. Result: From 2017 to 2019, there were 525 (1.1%) new AV patients out of a total of 45,754 new patients. AV was the major diagnosis in the Cosmetic Medic division. AV grades 2, 3, and 4 were found in 167 patients (32.0%). The most common lesion was papulopustular (75.4%) and the most common risk factor was hormonal (58.7%). All the patients received tretinoin, clindamycin gel 1.2%, and sunscreen for topical treatment. Doxycycline was the most common oral antibiotic used (98.2%) Conclusion: The most common AV grade in this study was mild AV. Oral antibiotics were given to moderate-to-severe AV patients in combination with topical treatment to prevent resistance.","PeriodicalId":8792,"journal":{"name":"Berkala Ilmu Kesehatan Kulit dan Kelamin","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73948085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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