Behavioural Brain Research最新文献_第2页

Corrigendum to "Glucocorticoid alleviates hypothalamic nerve injury via remodeling HPA axis homeostasis in stressed rats" [Behav. Brain Res. 475 (2024) 115223].

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-21 DOI: 10.1016/j.bbr.2025.115490

Shanyong Yi, Bin Zhao, Lai Wei, Zhijun Yao, Bin Yang

引用次数: 0

The light-dark forced swim test for simultaneous assessment of behavioral ‘despair’ and anxiety-like behavior in female mice

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115492

Sergey L. Khatsko , Alexander V. Zhdanov , Daria V. Kravchenko , Ekaterina V. Nikiforova , Natalya A. Salimova , Maria M. Kotova , David S. Galstyan , Murilo S. de Abreu , Longen Yang , Adam Michael Stewart , Allan V. Kalueff

Animal models are a valuable tool to study anxiety and depression, two common and severely debilitating brain disorders. Probing them experimentally typically relies on various rodent behavioral assays, such as the light-dark and the forced swim tests. However, the growing importance of testing novel CNS concepts and neuroactive drugs calls for further refinement of existing behavioral tests, as well as the development of new assays. One research strategy in this direction involves combining principles of several tests into one ‘hybrid’ assay. Using this approach, here we develop a novel ‘hybrid’ mouse assay, the light-dark forced swim test, combining features of the two conventional assays to simultaneously assess animal anxiety-like (light-dark preference during swimming) and depression-like behaviors (‘despair’-like immobility). Overall, the anxiety-like dark preference of female white outbred mice in this test is sensitive to physiological anxiogenic stressors (daily swimming or administration of prednisolone and dexamethasone), whereas clinically active antidepressants (fluoxetine and paroxetine) reduce despair-like immobility in this test. Collectively, these findings suggest that this novel assay may simultaneously evaluate anxiety- and depression-like behaviors, and can be applied to testing neuroactive drugs.

{"title":"The light-dark forced swim test for simultaneous assessment of behavioral ‘despair’ and anxiety-like behavior in female mice","authors":"Sergey L. Khatsko , Alexander V. Zhdanov , Daria V. Kravchenko , Ekaterina V. Nikiforova , Natalya A. Salimova , Maria M. Kotova , David S. Galstyan , Murilo S. de Abreu , Longen Yang , Adam Michael Stewart , Allan V. Kalueff","doi":"10.1016/j.bbr.2025.115492","DOIUrl":"10.1016/j.bbr.2025.115492","url":null,"abstract":"<div><div>Animal models are a valuable tool to study anxiety and depression, two common and severely debilitating brain disorders. Probing them experimentally typically relies on various rodent behavioral assays, such as the light-dark and the forced swim tests. However, the growing importance of testing novel CNS concepts and neuroactive drugs calls for further refinement of existing behavioral tests, as well as the development of new assays. One research strategy in this direction involves combining principles of several tests into one ‘hybrid’ assay. Using this approach, here we develop a novel ‘hybrid’ mouse assay, the light-dark forced swim test, combining features of the two conventional assays to simultaneously assess animal anxiety-like (light-dark preference during swimming) and depression-like behaviors (‘despair’-like immobility). Overall, the anxiety-like dark preference of female white outbred mice in this test is sensitive to physiological anxiogenic stressors (daily swimming or administration of prednisolone and dexamethasone), whereas clinically active antidepressants (fluoxetine and paroxetine) reduce despair-like immobility in this test. Collectively, these findings suggest that this novel assay may simultaneously evaluate anxiety- and depression-like behaviors, and can be applied to testing neuroactive drugs.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115492"},"PeriodicalIF":2.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical activation and functional connectivity in visual-cognitive-motor networks during motor-cognitive exercise

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115491

Thorben Hülsdünker , Maxime Laporte , Andreas Mierau , Daniel Büchel

Purpose

When compared to computer-based brain training, motor-cognitive exercises and exergaming claim to provide stronger brain activation and better transfer due to the integration of a more complex motor task. To evaluate if this is supported by neural dynamics, this study compared event-related potentials and connectivity between a cognitive and motor-cognitive training task.

Methods

21 participants performed a choice-reaction task with either an upper extremity button press (cognitive condition) or lower extremity stepping movement (motor-cognitive condition) input using the SKILLCOURT technology. The visual stimulation and cognitive task were identical. In addition to reaction time, neural activity was recorded using a 64-channel EEG system. Time course of neural activation and event-related potential data in visual premotor, primary motor and sensory regions of interest were compared between conditions. In addition, connectivity was calculated to identify differences in functional communication.

Results

Neural engagement was stronger in the motor-cognitive condition as reflected by a higher amplitude (p < 0.001) and longer latency (p = 0.02) of the BA6 negativity potential as well as higher activity in electrodes representing the foot region of the primary motor cortex (p < 0.001). This was accompanied by enhanced connectivity between electrodes covering the premotor cortex and frontal, primary motor and visual areas p < 0.05).

Conclusion

The findings suggest that the premotor cortex plays a key role in motor-cognitive training. This supports the assumption of stronger engagement of motor areas in motor-cognitive when compared to cognitive training and shed light on the neural processes that may underly superior training effects when compared to computer-based cognitive training.

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引用次数: 0

Neurocognitive mechanisms of social scenario imagery generation in individuals with social anxiety

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115488

Mingfan Liu , Guanlai Xiao , Genling Xiong

Cognitive behavioral theory emphasizes the significant role of mental imagery in the onset and development of Social Anxiety Disorder (SAD). However, the neural mechanisms underlying the generation of social scenario imagery in individuals with social anxiety remain unclear. In this study, 28 individuals with social anxiety and 31 healthy controls performed a retrospective cue imagery generation task to examine their neural responses. Behavioral results showed that, compared to negative social scenarios, the vividness of positive social scenario imagery was significantly lower in the social anxiety group, while the control group showed no significant difference between the two conditions. Event-related potential (ERP) results revealed that, for the social anxiety group, N170 and LPP amplitudes were significantly larger under the neutral condition compared to the negative condition, whereas the control group exhibited no significant difference between these conditions. Furthermore, the social anxiety group showed significantly larger LPP amplitudes than the control group in both the positive and neutral conditions. These findings provide the first neurophysiological evidence that individuals with social anxiety exhibit processing biases when generating imagery of positive and neutral social scenarios, suggesting heightened neural engagement in these conditions.

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引用次数: 0

Altered attentional control process of individuals with high test anxiety: An exploratory fMRI study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115486

Lulu Hou , Wenpei Zhang , Qiong Huang , Renlai Zhou

Test anxiety (TA) has been linked to abnormalities in attentional control not only for test-related information but also in situations where irrelevant information has to be ignored. However, the neural basis of individuals with high TA (HTA) when exposed to interference from different types of information remains limited. Twenty-two individuals with HTA and twenty-three individuals with low TA (LTA) completed a Stroop task integrating emotional-word and color-word Stroop tasks. Participants were instructed to assess the font color of neutral words, generally threatening words, test-related threatening words, color-congruent words, and color-incongruent words. Functional magnetic resonance imaging data were recorded simultaneously as the task was completed. The results indicated that compared with LTA group, HTA group exhibited higher activation in the right postcentral gyrus, left cerebellum, right calcarine gyrus, and left inferior parietal lobule when individuals were exposed to interference by test-related threatening words as opposed to neutral words. However, no clusters with significant group-related differences were found when individuals were exposed to interference by generally threatening words and color-incongruent words. These results suggested that differences in attentional control processes between high- and low-test anxiety groups were mainly limited to test-related threatening stimuli and did not extend to generally threatening and cognitively task-irrelevant stimuli.

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引用次数: 0

Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115493

Leilei Shi , Mingmei Wang , Ruixuan Yu , Yuyu An , Xin Wang , Yuhan Zhang , Yongheng Shi , Chaojun Han , Jiping Liu

Sigma-1 receptor (Sig-1R) agonists has therapeutic effects in neurological disorders and possesses properties that can reverse cognitive dysfunction. This study investigated the therapeutic efficacy of Sig-1R activation on cognitive dysfunction in streptozotocin (STZ) combined with high fat and high sugar diet (HFD)-induced type 2 diabetic rats. By employing morris water maze (MWM) testing and computed tomography (CT) imaging, we observed that activation of Sig-1R effectively mitigated brain atrophy and cognitive impairment in diabetes-induced cognitive impairment (DCI) rats. Given the fundamental role of intact hippocampal synaptic plasticity in maintaining cognitive function, we investigated the correlation between Sig-1R and Brain-Derived Neurotrophic Factor (BDNF), a well-established neurotrophic factor. And we also analyzed the expression of Postsynaptic density protein-95 (PSD95) protein. Golgi staining, Haematoxylin-eosin (HE) staining, Nissl staining, and immunofluorescence results show that activating Sig-1R can upregulate BDNF expression and reducing synaptic damage in hippocampal neurons. To elucidate the mechanism by which Sig-1R activation leads to increased BDNF levels, we investigated the Extracellular Signal-Regulated Kinase/Cyclic AMP Response Element-Binding Protein(ERK/CREB) protein pathway. In vitro and in vivo, we observed that Sig-1R activates the ERK/CREB signaling pathway, thereby stimulating BDNF release and increased PSD95 expression. Further intervention with BD1047 antagonist and Tropomyosin-Related Kinase B (TrkB) antagonist ANA-12 confirmed our conclusion that Sig-1R activation upregulated p-ERK and p-CREB protein expression, promoted BDNF transcription, the expression of PSD95 protein was up-regulated, reduces synaptic damage in damaged hippocampal neurons, and rescued cognitive impairment in DCI rats.

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引用次数: 0

Valence-dependent contribution by the basolateral amygdala to active but not inhibitory avoidance and reward-seeking

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-20 DOI: 10.1016/j.bbr.2025.115503

Gemma L. Dalton, Ian D. Daly, Stan B. Floresco

The basolateral amygdala (BLA) is integral for promoting instrumental actions to avoid aversive events, and also contributes to certain aspects of reward-seeking. However, this sometimes requires discriminating between stimuli to ascertain whether it is more appropriate to initiate or suppress actions to obtain these goals. The present study examined BLA involvement in different avoidance strategies in male and female rats well-trained on different lever-press avoidance and reward-seeking tasks. Active/inhibitory avoidance required discrimination between tones presented pseudorandomly in a session that signaled shocks could be avoided by making or withholding a press on a lever inserted coincidentally with tone presentation. BLA inactivation (via infusion of GABA agonists) reduced active avoidance while slightly enhancing inhibitory avoidance in the same session. Similarly, on a dual-cued appetitive go/no-go task, BLA inactivation also impaired active, but not inhibitory reward-seeking. These treatments also disrupted performance in rats trained on a simpler, single-cue active avoidance task with no inhibitory component. However, rats trained on a single-cue reward task were impervious to the effects of BLA inactivation. Few sex differences were observed. These data reveal a fundamental contribution by the BLA in promoting actions to avoid punishments or secure rewards when an actor must discriminate between different stimuli to ascertain whether actions should be made or withheld, and may attenuate inhibitory avoidance when active strategies are sometimes required. Yet, under more rudimentary conditions where a single stimulus provokes actions, the valence of the pursued goal biases BLA involvement, as it remains critical for instrumental avoidance, but not reward-seeking.

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引用次数: 0

The threshold for intracranial self-stimulation does not increase in rats exposed to chronic unpredictable stress – A systematic review and meta-analysis

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-19 DOI: 10.1016/j.bbr.2025.115483

Jenny Paola Berrio Sanchez , Jenny Wilzopolski , Katharina Hohlbaum , Otto Kalliokoski

The chronic unpredictable stress model is a rodent model of stress-induced anhedonia. The sucrose preference test, often used to validate it, is unreliable. Intracranial self-stimulation offers an alternative and is often cited as supporting evidence of the model's validity. Our aim was to assess whether an increased self-stimulation threshold is found after stress and if such a change correlates with decreases in sweet consumption. We searched PubMed, Embase (ovid), and Web of Science for studies in rats exposed to chronic unpredictable stress that employed intracranial self-stimulation. Thresholds for stressed and control animals were pooled from 11 studies that collectively reported on 23 different experiments. Over 50 % of the data was contributed by one research group, so a three-level meta-analytical random effects model was fit to account for methodological differences between different networks of researchers. After this adjustment, we did not find that the self-stimulation thresholds were increased in stressed rats. Pioneering experiments with positive results failed to be replicated by others, although no specific factor could be pointed to as a likely explanation. What is more, the available evidence suggests a lack of connection between sweet preference and self-stimulation, although this relationship has been seldom investigated. No study reported correlation coefficients. Methods known to mitigate biases were frequently absent, as was a transparent report of crucial study details. Our findings challenge the claim made in support of the validity of the model. Further efforts would be well-invested in assessing how reliably other tests of anhedonia have found the effects of the chronic unpredictable stress model.

{"title":"The threshold for intracranial self-stimulation does not increase in rats exposed to chronic unpredictable stress – A systematic review and meta-analysis","authors":"Jenny Paola Berrio Sanchez , Jenny Wilzopolski , Katharina Hohlbaum , Otto Kalliokoski","doi":"10.1016/j.bbr.2025.115483","DOIUrl":"10.1016/j.bbr.2025.115483","url":null,"abstract":"<div><div>The chronic unpredictable stress model is a rodent model of stress-induced anhedonia. The sucrose preference test, often used to validate it, is unreliable. Intracranial self-stimulation offers an alternative and is often cited as supporting evidence of the model's validity. Our aim was to assess whether an increased self-stimulation threshold is found after stress and if such a change correlates with decreases in sweet consumption. We searched PubMed, Embase (ovid), and Web of Science for studies in rats exposed to chronic unpredictable stress that employed intracranial self-stimulation. Thresholds for stressed and control animals were pooled from 11 studies that collectively reported on 23 different experiments. Over 50 % of the data was contributed by one research group, so a three-level meta-analytical random effects model was fit to account for methodological differences between different networks of researchers. After this adjustment, we did not find that the self-stimulation thresholds were increased in stressed rats. Pioneering experiments with positive results failed to be replicated by others, although no specific factor could be pointed to as a likely explanation. What is more, the available evidence suggests a lack of connection between sweet preference and self-stimulation, although this relationship has been seldom investigated. No study reported correlation coefficients. Methods known to mitigate biases were frequently absent, as was a transparent report of crucial study details. Our findings challenge the claim made in support of the validity of the model. Further efforts would be well-invested in assessing how reliably other tests of anhedonia have found the effects of the chronic unpredictable stress model.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115483"},"PeriodicalIF":2.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital anosmia and subjective tactile function: A pilot study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-19 DOI: 10.1016/j.bbr.2025.115487

Supreet Saluja , Anna Laura Tóth , Moa G. Peter , Robin Fondberg , Arnaud Tognetti , Johan N. Lundström

Anosmia, the complete loss of olfactory perception, has been associated with sensory compensation in non-chemical senses such as vision and hearing, but its relationship with tactile perception remains unclear. This study investigates whether isolated congenital anosmia (ICA)—a rare condition in which individuals are born without a sense of smell but are otherwise healthy—is linked to heightened self-reported tactile sensitivity compared to healthy controls. Drawing on sensory compensation theory and anecdotal evidence from related studies, we hypothesized that individuals with ICA would report increased tactile sensitivity, particularly in response to discomfort. To test this hypothesis, we surveyed individuals with ICA (n = 40) and healthy controls (n = 40), matched for sex and age, using standardized questionnaires and a specially developed questionnaire focused on discomfort related to materials, food textures, stickiness, and pressure. Contrary to our pre-registered hypothesis, the results revealed no significant differences in overall self-reported touch sensitivity between the groups. However, exploratory analysis indicated that individuals with ICA exhibit greater sensitivity to temperature sensations and to overall tactile discomfort, specifically in response to pressure and food textures, compared to controls. We propose that individuals with ICA may compensate for their olfactory loss through heightened sensitivity to certain tactile stimuli related to discomfort, as both touch and olfaction play overlapping roles in the detection of aversive stimuli. These exploratory findings underscore the need for further investigation into the sensory compensation mechanisms of olfaction on touch.

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引用次数: 0

Post acquisition 5-HT6 receptor agonist EMD386088 administration impairs consolidation of a spatial discrimination in mice

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-18 DOI: 10.1016/j.bbr.2025.115489

Jasmine Alyssa Robinson , Dionisio Antonio Amodeo

The serotonergic system has been known to play an important role in acquisition, consolidation and retrieval of memories. Specific serotonin (5-HT) receptor modulation can effectively impact the consolidation of these memories. Determining how specific 5-HT receptor modulation can impact consolidation of spatial memories has been examined, although the 5-HT6 receptor has not been a focus of such studies. The current study aims examine the impact of 5-HT6 receptor agonist EMD386088 administration on the consolidation of a probabilistic spatial discrimination. Female and male C57BL/6 J mice were trained on a probabilistic spatial discrimination then received acute systemic injections of either 0, 1 or 5 mg/kg EMD386088 immediately after reaching learning criterion for the spatial discrimination, targeting the consolidation window. During the retention test, both doses of 1 mg/kg and 5 mg/kg significantly impaired performance in both female and male C57BL/6 J mice. Although there were no significant differences between the two doses, mice treated with either dose of EMD386088 required significantly more trials to reach retention criterion compared to vehicle-treated mice. These learning impairments were independent of effects on locomotor measures due to the comparable trials per min across all treatment groups during both the acquisition and retention tests. The current findings demonstrate the potential sensitivity of treatment timing in the application of novel therapeutics aimed at stimulating 5-HT6 receptors and their impact on memory.

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引用次数: 0