Pub Date : 2024-12-10DOI: 10.1016/j.bbr.2024.115394
Rosalinda Calandrelli , Francesco Motolese , Carlo Augusto Mallio , Vincenzo Di Lazzaro , Fabio Pilato
A well-known link exists between cerebrovascular disease and chronic kidney disease. Cerebrovascular pathology in patients with kidney disease may be asymptomatic and occasionally discovered through neuroradiological examinations or it may present with neurological symptoms. Covert cerebrovascular lesions represent the earliest injuries associated with chronic kidney disease and primarily result from small vessel damage. These conditions often manifest incidentally, appearing as structural changes (such as lacunes, white matter lesions, enlarged perivascular spaces, cerebral microbleeds, and atrophy) as well as microstructural and hemodynamic alterations, detectable through routine and advanced functional MRIs. These alterations may be associated with a higher risk of stroke, cognitive decline, and dementia. Patients with end-stage renal disease or chronic kidney disease undergoing dialysis may be at increased risk of large-artery atherosclerosis, cardio-embolism, or small-vessel occlusion, and they may experience symptomatic acute ischemic strokes as rare complications. Currently, there are no established guidelines or standardized diagnostic protocols for preventing cerebrovascular disease in patients with kidney disease. Clinical and radiological studies are warranted to evaluate the usefulness of incorporating neuroimaging into the diagnostic work-up of these patients in order to improve prognosis and reduce diagnostic delays.
{"title":"A pictorial neuroradiological review of brain vascular abnormalities in patients with kidney disease","authors":"Rosalinda Calandrelli , Francesco Motolese , Carlo Augusto Mallio , Vincenzo Di Lazzaro , Fabio Pilato","doi":"10.1016/j.bbr.2024.115394","DOIUrl":"10.1016/j.bbr.2024.115394","url":null,"abstract":"<div><div>A well-known link exists between cerebrovascular disease and chronic kidney disease. Cerebrovascular pathology in patients with kidney disease may be asymptomatic and occasionally discovered through neuroradiological examinations or it may present with neurological symptoms. Covert cerebrovascular lesions represent the earliest injuries associated with chronic kidney disease and primarily result from small vessel damage. These conditions often manifest incidentally, appearing as structural changes (such as lacunes, white matter lesions, enlarged perivascular spaces, cerebral microbleeds, and atrophy) as well as microstructural and hemodynamic alterations, detectable through routine and advanced functional MRIs. These alterations may be associated with a higher risk of stroke, cognitive decline, and dementia. Patients with end-stage renal disease or chronic kidney disease undergoing dialysis may be at increased risk of large-artery atherosclerosis, cardio-embolism, or small-vessel occlusion, and they may experience symptomatic acute ischemic strokes as rare complications. Currently, there are no established guidelines or standardized diagnostic protocols for preventing cerebrovascular disease in patients with kidney disease. Clinical and radiological studies are warranted to evaluate the usefulness of incorporating neuroimaging into the diagnostic work-up of these patients in order to improve prognosis and reduce diagnostic delays.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115394"},"PeriodicalIF":2.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-10DOI: 10.1016/j.bbr.2024.115392
Abdullah Al Shamsh Prottay , Emamuzzaman , Tawfik Rakaiyat Ripu , Md. Nazim Sarwar , Towfiqur Rahman , Md. Shakil Ahmmed , Mehedi Hasan Bappi , Md. Emon , Siddique Akber Ansari , Henrique D.M. Coutinho , Muhammad Torequl Islam
Background
Anxiety disorder is the most common mental illness and a major contributor to impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety. It is widely recognized that the neurobiology of anxiety-related behavior involves GABAergic systems.
Objectives
This research aimed to examine the anxiogenic action of coumarin (CMN), a natural benzopyrone derived from plants, and determine its underlying mechanism through in vivo and in silico investigations.
Methods
This was accomplished by using a variety of behavioral procedures, including open field, swing, hole cross, and light-dark tests, on male and female Swiss albino mice that had been orally administered three experimental doses of CMN (1, 2, and 4 mg/kg). The CMN group was also examined with the GABAA receptor agonist diazepam (DZP, 2 mg/kg) and flumazenil antagonist (FLU, 0.1 mg/kg). Furthermore, CMN and standards were subjected to a molecular docking analysis to determine their binding affinities for the GABAA receptor subunits (α1, α4, β2, γ2, and δ). Several software programs were used to visualize the ligand-receptor interaction and analyze the pharmacokinetic profile.
Results
Compared to typical treatments, our results show that CMN (1 mg/kg) significantly (p < 0.05) increases the locomotor activity of animals. Furthermore, CMN exerted the highest binding affinity (−6.5 kcal/mol) with the GABA-α1 receptor compared to conventional DZP. Along with FLU, CMN displayed several hydrophobic and hydrogen bonds with GABAA receptor subunits. The pharmacokinetic and drug-like properties of CMN are also remarkable. In animal studies, CMN worked synergistically with FLU to provide anxiogenic-like effects.
Conclusion
We conclude that, based on in vivo and in silico data, CMN, alone or in combination with FLU, may be employed in future neurological clinical studies. However, further research is needed to confirm this behavioral activity and elucidate the possible mechanism of action.
{"title":"Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches","authors":"Abdullah Al Shamsh Prottay , Emamuzzaman , Tawfik Rakaiyat Ripu , Md. Nazim Sarwar , Towfiqur Rahman , Md. Shakil Ahmmed , Mehedi Hasan Bappi , Md. Emon , Siddique Akber Ansari , Henrique D.M. Coutinho , Muhammad Torequl Islam","doi":"10.1016/j.bbr.2024.115392","DOIUrl":"10.1016/j.bbr.2024.115392","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety disorder is the most common mental illness and a major contributor to impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety. It is widely recognized that the neurobiology of anxiety-related behavior involves GABAergic systems.</div></div><div><h3>Objectives</h3><div>This research aimed to examine the anxiogenic action of coumarin (CMN), a natural benzopyrone derived from plants, and determine its underlying mechanism through <em>in vivo</em> and <em>in silico</em> investigations.</div></div><div><h3>Methods</h3><div>This was accomplished by using a variety of behavioral procedures, including open field, swing, hole cross, and light-dark tests, on male and female <em>Swiss</em> albino mice that had been orally administered three experimental doses of CMN (1, 2, and 4 mg/kg). The CMN group was also examined with the GABA<sub>A</sub> receptor agonist diazepam (DZP, 2 mg/kg) and flumazenil antagonist (FLU, 0.1 mg/kg). Furthermore, CMN and standards were subjected to a molecular docking analysis to determine their binding affinities for the GABA<sub>A</sub> receptor subunits (α1, α4, β2, γ2, and δ). Several software programs were used to visualize the ligand-receptor interaction and analyze the pharmacokinetic profile.</div></div><div><h3>Results</h3><div>Compared to typical treatments, our results show that CMN (1 mg/kg) significantly (p < 0.05) increases the locomotor activity of animals. Furthermore, CMN exerted the highest binding affinity (−6.5 kcal/mol) with the GABA-α1 receptor compared to conventional DZP. Along with FLU, CMN displayed several hydrophobic and hydrogen bonds with GABA<sub>A</sub> receptor subunits. The pharmacokinetic and drug-<em>like</em> properties of CMN are also remarkable. In animal studies, CMN worked synergistically with FLU to provide anxiogenic-like effects.</div></div><div><h3>Conclusion</h3><div>We conclude that, based on <em>in vivo</em> and <em>in silico</em> data, CMN, alone or in combination with FLU, may be employed in future neurological clinical studies. However, further research is needed to confirm this behavioral activity and elucidate the possible mechanism of action.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115392"},"PeriodicalIF":2.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitochondrial dysfunction and brain insulin resistance have been related to Alzheimer's disease (AD) development. Streptozotocin (STZ) is commonly employed to disrupt glucose and insulin metabolism, even causing cognitive impairment in animal models. We aimed at studying the protective effect of JM-20 on STZ-induced memory impairment and brain mitochondrial dysfunction.
Methods
Male C57Bl6 mice received 3 mg/kg STZ intracerebroventricularly and JM-20 (0.25 mg/kg or 4 mg/kg) was administered daily by gastric gavage. Episodic memory was evaluated through Y-maze, novel object recognition, and Morris water maze. Endogenous antioxidant systems (catalase and superoxide dismutase activities), total sulfhydryl groups, malondialdehyde levels were also studied and acetylcholinesterase (AChE) activity were assessed in the prefrontal cortex (PC) and hippocampus (HO).
Results
demonstrated that STZ injection impaired recognition and spatial learning and memory and oxygen flow in all mitochondrial respiration states. Additionally, STZ increased AChE, superoxide dismutase, and catalase activity in the PC but not in HO tissue. A neuroprotective effect of JM-20 on STZ-induced memory decline, and mitochondrial dysfunction was observed, suggesting an important causal interaction. In addition, JM-20 was able to decreased AChE enzyme hyperactivity, rescued endogenous antioxidant systems, and prevented histologically observed neuronal damage
Conclusion
Our results indicate that JM-20 protects against STZ-induced impairment in brain bioenergetic metabolism and memory, confirming its potential as a candidate for treating neurodegenerative disorders associated with mitochondrial dysfunction like AD.
{"title":"Mitochondrial protective properties exerted by JM-20 in a dementia model induced by intracerebroventricular administration of streptozotocin in mice","authors":"Maylin Wong-Guerra , Yanay Montano-Peguero , Daniela Hernández-Enseñat , Jeney Ramírez-Sánchez , Abel Mondelo-Rodríguez , Alejandro Saúl Padrón-Yaquis , Enrique García-Alfonso , Luis Arturo Fonseca-Fonseca , Yanier Nuñez-Figueredo","doi":"10.1016/j.bbr.2024.115385","DOIUrl":"10.1016/j.bbr.2024.115385","url":null,"abstract":"<div><h3>Background</h3><div>Mitochondrial dysfunction and brain insulin resistance have been related to Alzheimer's disease (AD) development. Streptozotocin (STZ) is commonly employed to disrupt glucose and insulin metabolism, even causing cognitive impairment in animal models. We aimed at studying the protective effect of JM-20 on STZ-induced memory impairment and brain mitochondrial dysfunction.</div></div><div><h3>Methods</h3><div>Male C57Bl6 mice received 3 mg/kg STZ intracerebroventricularly and JM-20 (0.25 mg/kg or 4 mg/kg) was administered daily by gastric gavage. Episodic memory was evaluated through Y-maze, novel object recognition, and Morris water maze. Endogenous antioxidant systems (catalase and superoxide dismutase activities), total sulfhydryl groups, malondialdehyde levels were also studied and acetylcholinesterase (AChE) activity were assessed in the prefrontal cortex (PC) and hippocampus (HO).</div></div><div><h3>Results</h3><div>demonstrated that STZ injection impaired recognition and spatial learning and memory and oxygen flow in all mitochondrial respiration states. Additionally, STZ increased AChE, superoxide dismutase, and catalase activity in the PC but not in HO tissue. A neuroprotective effect of JM-20 on STZ-induced memory decline, and mitochondrial dysfunction was observed, suggesting an important causal interaction. In addition, JM-20 was able to decreased AChE enzyme hyperactivity, rescued endogenous antioxidant systems, and prevented histologically observed neuronal damage</div></div><div><h3>Conclusion</h3><div>Our results indicate that JM-20 protects against STZ-induced impairment in brain bioenergetic metabolism and memory, confirming its potential as a candidate for treating neurodegenerative disorders associated with mitochondrial dysfunction like AD.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115385"},"PeriodicalIF":2.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-07DOI: 10.1016/j.bbr.2024.115369
Shay Ohayon , Ilanit Gordon
This systematic review and meta-analysis examined the interplay among neural, physiological, and behavioral interpersonal synchrony. We included studies written in English, comprising human dyads, and reporting data that could be translated to correlation estimates between at least two modalities of synchrony, sourced from PsycINFO, PubMed, and Google Scholar. The initial meta-analysis, examining associations between neural and behavioral synchrony, assessed 37 samples with 1342 participants, revealed a significant medium effect size (r = 0.32, 95 %CI: [0.23, 0.41]) with higher correlations in studies measured frontocentral regions and used the same epoch size for synchrony calculations. The analysis on associations between physiological and behavioral synchrony included 13 samples (369 participants) and identified small effect size (r = 0.18, 95 %CI: [0.06, 0.30]). Due to the limited sample size of three studies involving 150 participants, we conducted a systematic review rather than a meta-analysis to examine the relationship between neural and physiological synchrony. This review revealed inconsistent results, underscoring the need for further research. Future inquiries address greater multimodal integration in certain brain regions and measures, such as frontal and central regions. A theoretical framework that will explain multimodal integration of synchrony will allow us to ascertain if it is a unique aspect of social experiences, or simply a description of synchrony across levels of organization.
{"title":"Multimodal interpersonal synchrony: Systematic review and meta-analysis","authors":"Shay Ohayon , Ilanit Gordon","doi":"10.1016/j.bbr.2024.115369","DOIUrl":"10.1016/j.bbr.2024.115369","url":null,"abstract":"<div><div>This systematic review and meta-analysis examined the interplay among neural, physiological, and behavioral interpersonal synchrony. We included studies written in English, comprising human dyads, and reporting data that could be translated to correlation estimates between at least two modalities of synchrony, sourced from PsycINFO, PubMed, and Google Scholar. The initial meta-analysis, examining associations between neural and behavioral synchrony, assessed 37 samples with 1342 participants, revealed a significant medium effect size (r = 0.32, 95 %CI: [0.23, 0.41]) with higher correlations in studies measured frontocentral regions and used the same epoch size for synchrony calculations. The analysis on associations between physiological and behavioral synchrony included 13 samples (369 participants) and identified small effect size (r = 0.18, 95 %CI: [0.06, 0.30]). Due to the limited sample size of three studies involving 150 participants, we conducted a systematic review rather than a meta-analysis to examine the relationship between neural and physiological synchrony. This review revealed inconsistent results, underscoring the need for further research. Future inquiries address greater multimodal integration in certain brain regions and measures, such as frontal and central regions. A theoretical framework that will explain multimodal integration of synchrony will allow us to ascertain if it is a unique aspect of social experiences, or simply a description of synchrony across levels of organization.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115369"},"PeriodicalIF":2.6,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-06DOI: 10.1016/j.bbr.2024.115390
Marcelo Heinemann Presa , Marcia Juciele da Rocha , Kauane Nayara Bahr Ledebuhr , Narryman Pinto Zuge , Taís Barcelos Goulart , Diego Alves , Cristiani Folharini Bortolatto , César Augusto Brüning
1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone (ETAP) is a novel hybrid compound containing 1,2,3-triazole and acetophenone. It exhibits antidepressant-like effects in male mice, linked to modulation of serotonergic receptors and monoamine oxidase A (MAO-A) inhibition. This study aimed to evaluate the involvement of the dopaminergic and noradrenergic systems, as well as MAO-B activity inhibition, in the antidepressant-like effect of ETAP in male mice, and to evaluate the antidepressant-like effect of ETAP in female mice. Male mice were treated with different dopaminergic and noradrenergic receptors antagonists 15 min before administering ETAP (1 mg/kg, intragastrically, i.g.). The tail suspension test (TST) was performed 30 minutes later. Different male mice were treated with ETAP (1 mg/kg, i.g.), and 30 minutes later, were euthanized to assess MAO-B activity in the prefrontal cortex and hippocampus. To evaluate the antidepressant-like of ETAP in female mice, ETAP (1 mg/kg, i.g.) was administered, followed by the TST and the forced swimming test (FST) 30 minutes later. The dopaminergic antagonists haloperidol (0.05 mg/kg, intraperitoneally, i.p.), SCH23390 (0.01 mg/kg, subcutaneously, s.c.), and sulpiride (50 mg/kg, i.p.), as well the noradrenergic antagonists prazosin (1 mg/kg, i.p.), yohimbine (1 mg/kg, i.p.), and propranolol (2 mg/kg, i.p.), prevented the antidepressant-like effect of ETAP in the TST. MAO-B activity was unaffected by ETAP in both the prefrontal cortex and hippocampus. ETAP (1 mg/kg, i.g.) induced a significant antidepressant-like effect in female mice in the TST and FST. These findings provide valuable insights into the antidepressant-like effect of ETAP, highlighting its potential for developing more effective depression treatments.
{"title":"Exploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone in mice","authors":"Marcelo Heinemann Presa , Marcia Juciele da Rocha , Kauane Nayara Bahr Ledebuhr , Narryman Pinto Zuge , Taís Barcelos Goulart , Diego Alves , Cristiani Folharini Bortolatto , César Augusto Brüning","doi":"10.1016/j.bbr.2024.115390","DOIUrl":"10.1016/j.bbr.2024.115390","url":null,"abstract":"<div><div>1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone (ETAP) is a novel hybrid compound containing 1,2,3-triazole and acetophenone. It exhibits antidepressant-like effects in male mice, linked to modulation of serotonergic receptors and monoamine oxidase A (MAO-A) inhibition. This study aimed to evaluate the involvement of the dopaminergic and noradrenergic systems, as well as MAO-B activity inhibition, in the antidepressant-like effect of ETAP in male mice, and to evaluate the antidepressant-like effect of ETAP in female mice. Male mice were treated with different dopaminergic and noradrenergic receptors antagonists 15 min before administering ETAP (1 mg/kg, intragastrically, i.g.). The tail suspension test (TST) was performed 30 minutes later. Different male mice were treated with ETAP (1 mg/kg, i.g.), and 30 minutes later, were euthanized to assess MAO-B activity in the prefrontal cortex and hippocampus. To evaluate the antidepressant-like of ETAP in female mice, ETAP (1 mg/kg, i.g.) was administered, followed by the TST and the forced swimming test (FST) 30 minutes later. The dopaminergic antagonists haloperidol (0.05 mg/kg, intraperitoneally, i.p.), SCH23390 (0.01 mg/kg, subcutaneously, s.c.), and sulpiride (50 mg/kg, i.p.), as well the noradrenergic antagonists prazosin (1 mg/kg, i.p.), yohimbine (1 mg/kg, i.p.), and propranolol (2 mg/kg, i.p.), prevented the antidepressant-like effect of ETAP in the TST. MAO-B activity was unaffected by ETAP in both the prefrontal cortex and hippocampus. ETAP (1 mg/kg, i.g.) induced a significant antidepressant-like effect in female mice in the TST and FST. These findings provide valuable insights into the antidepressant-like effect of ETAP, highlighting its potential for developing more effective depression treatments.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115390"},"PeriodicalIF":2.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-06DOI: 10.1016/j.bbr.2024.115389
Kathleen J. Peters, Elias Daher, Anthony N. Carlsen
The ability to perceive a tactile stimulus is reduced in a moving limb, a phenomenon known as tactile suppression. This sensory attenuation effect is attributed to movement-related gating, which allows the central nervous system to selectively process sensory information. However, the source of this gating is uncertain, with some evidence suggesting a forward-model origin of tactile suppression, and other evidence in support of backward masking from peripheral reafference. This study investigated the contribution of these mechanisms to tactile suppression by employing a startling acoustic stimulus (SAS) to involuntarily trigger the early release of a planned movement. A forward-model account would predict that the timing of the suppression would align with the anticipated time of voluntary response initiation, whereas a reafference account would predict that suppression timing would be linked directly to the actual time of the motor act. Participants (n = 27) performed a simple reaction time task involving a rapid wrist extension to release a switch in response to an auditory go-signal, which was occasionally replaced with a 120 dB SAS. On each trial, participants reported whether they detected a near-threshold electrical stimulus applied to the moving hand at various times (50–170ms; 30 ms steps) after the go-signal. Results showed a significantly lower detection rate on SAS trials at all stimulation times (p < .001), supporting the proposition that suppression does not depend on the predicted timing of voluntary initiation, but rather is linked to the production of the motor response. Furthermore, detection rate was significantly lower on SAS trials even when time-locked to movement onset, suggesting that the SAS may have further impeded sensory processing (p < .001).
{"title":"Tactile suppression is linked to movement onset for startle-triggered responses","authors":"Kathleen J. Peters, Elias Daher, Anthony N. Carlsen","doi":"10.1016/j.bbr.2024.115389","DOIUrl":"10.1016/j.bbr.2024.115389","url":null,"abstract":"<div><div>The ability to perceive a tactile stimulus is reduced in a moving limb, a phenomenon known as tactile suppression. This sensory attenuation effect is attributed to movement-related gating, which allows the central nervous system to selectively process sensory information. However, the source of this gating is uncertain, with some evidence suggesting a forward-model origin of tactile suppression, and other evidence in support of backward masking from peripheral reafference. This study investigated the contribution of these mechanisms to tactile suppression by employing a startling acoustic stimulus (SAS) to involuntarily trigger the early release of a planned movement. A forward-model account would predict that the timing of the suppression would align with the <em>anticipated</em> time of voluntary response initiation, whereas a reafference account would predict that suppression timing would be linked directly to the <em>actual</em> time of the motor act. Participants (n = 27) performed a simple reaction time task involving a rapid wrist extension to release a switch in response to an auditory go-signal, which was occasionally replaced with a 120 dB SAS. On each trial, participants reported whether they detected a near-threshold electrical stimulus applied to the moving hand at various times (50–170ms; 30 ms steps) after the go-signal. Results showed a significantly lower detection rate on SAS trials at all stimulation times (p < .001), supporting the proposition that suppression does not depend on the predicted timing of voluntary initiation, but rather is linked to the production of the motor response. Furthermore, detection rate was significantly lower on SAS trials even when time-locked to movement onset, suggesting that the SAS may have further impeded sensory processing (p < .001).</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115389"},"PeriodicalIF":2.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.bbr.2024.115384
Yimeng Wang , Xueling Wang , Ling Wang , Li Zheng , Xingwei An , Chenguang Zheng
Alzheimer’s disease (AD) is a typical neurodegenerative disease featuring deficits in spatial memory, which relies on spatial representations by hippocampal place cells. Place cells exhibit task-responsive representation to support memory encoding and retrieval processes. Yet, it remains unclear how this task-responsive spatial representation was interrupted under AD pathologies. Here, we employed a delayed match-to-place spatial memory task with associative and predictive memory processes, during which we electrophysiologically recorded hippocampal place cells with multi-tetrode hyperdrives in rats with i.c.v. amyloid/saline injection. We found that the directional selectivity of place cells coding was maintained in the Amyloid group. The firing stability was higher during predictive memory than during associative memory in both groups. However, the spatial specificity was decreased in the Amyloid group during both associative and predictive memory. Importantly, the place cells in the Amyloid group exhibited attenuated task-responsive representations, i.e. lack of spatial over-representations towards the goal zone and a higher representation of the rest zone, especially during the predictive memory stage. These results raise a hypothesis that the disrupted task-responsive representations of place cells could be an underlying mechanism of spatial memory deficits induced by amyloid proteins.
{"title":"Attenuated task-responsive representations of hippocampal place cells induced by amyloid-beta accumulation","authors":"Yimeng Wang , Xueling Wang , Ling Wang , Li Zheng , Xingwei An , Chenguang Zheng","doi":"10.1016/j.bbr.2024.115384","DOIUrl":"10.1016/j.bbr.2024.115384","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a typical neurodegenerative disease featuring deficits in spatial memory, which relies on spatial representations by hippocampal place cells. Place cells exhibit task-responsive representation to support memory encoding and retrieval processes. Yet, it remains unclear how this task-responsive spatial representation was interrupted under AD pathologies. Here, we employed a delayed match-to-place spatial memory task with associative and predictive memory processes, during which we electrophysiologically recorded hippocampal place cells with multi-tetrode hyperdrives in rats with i.c.v. amyloid/saline injection. We found that the directional selectivity of place cells coding was maintained in the Amyloid group. The firing stability was higher during predictive memory than during associative memory in both groups. However, the spatial specificity was decreased in the Amyloid group during both associative and predictive memory. Importantly, the place cells in the Amyloid group exhibited attenuated task-responsive representations, i.e. lack of spatial over-representations towards the goal zone and a higher representation of the rest zone, especially during the predictive memory stage. These results raise a hypothesis that the disrupted task-responsive representations of place cells could be an underlying mechanism of spatial memory deficits induced by amyloid proteins.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115384"},"PeriodicalIF":2.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.bbr.2024.115387
Farah Wahida Suhaimi , Nurul Husna Mohamad Khari , Zurina Hassan , Christian P. Müller
Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.
{"title":"Exploring the cognitive effects of kratom: A review","authors":"Farah Wahida Suhaimi , Nurul Husna Mohamad Khari , Zurina Hassan , Christian P. Müller","doi":"10.1016/j.bbr.2024.115387","DOIUrl":"10.1016/j.bbr.2024.115387","url":null,"abstract":"<div><div>Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115387"},"PeriodicalIF":2.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.bbr.2024.115386
Seyed Hani Hojjati , Kewei Chen , Gloria C. Chiang , Amy Kuceyeski , Xiuyuan H. Wang , Qolamreza R. Razlighi , Silky Pahlajani , Lidia Glodzik , Emily B. Tanzi , Michael Reinhardt , Tracy A. Butler
Late-onset psychosis (LOP) represents a highly heterogeneous and understudied condition, with potential origins ranging from atypically late onset of schizophrenia (SCZ) to Alzheimer's Disease (AD). Despite the clinical necessity of differentiating these conditions to guide effective treatment, achieving an accurate diagnosis remains challenging. This study aimed to utilize data-driven analyses of structural magnetic resonance imaging (MRI) to distinguish between these diagnostic possibilities. Utilizing publicly available datasets of MRI scans from 699 healthy control (HC) participants and 469 patients diagnosed with SCZ or AD, our analysis focused on bilateral subcortical volumetric measures in the caudate, hippocampus, putamen, and amygdala. We first trained an unsupervised K-means clustering algorithm based on SCZ and AD patients and achieved a clustering accuracy of 81 % and an area under curvature (AUC) of 0.79 in distinguishing between these two groups. Subsequently, we calculated the Euclidean distance between the AD and SCZ cluster centroids for each of ten patients with unexplained onset of psychosis after age 45 from a clinical MRI registry. Six patients were classified as AD and four as SCZ. Our findings revealed that among LOP participants, those classified in the SCZ cluster exhibited significantly greater right putamen volumes compared to those in the AD cluster (p < 0.0025). There were also intriguing clinical differences. While we do not have diagnostic biomarker information to confirm these classifications, this study sheds light on the heterogeneity of psychoses in late life and illustrates the potential use of widely available structural MRI and data-driven methods to enhance diagnostic accuracy and treatment outcomes for LOP patients.
{"title":"Utilizing structural MRI and unsupervised clustering to differentiate schizophrenia and Alzheimer's disease in late-onset psychosis","authors":"Seyed Hani Hojjati , Kewei Chen , Gloria C. Chiang , Amy Kuceyeski , Xiuyuan H. Wang , Qolamreza R. Razlighi , Silky Pahlajani , Lidia Glodzik , Emily B. Tanzi , Michael Reinhardt , Tracy A. Butler","doi":"10.1016/j.bbr.2024.115386","DOIUrl":"10.1016/j.bbr.2024.115386","url":null,"abstract":"<div><div>Late-onset psychosis (LOP) represents a highly heterogeneous and understudied condition, with potential origins ranging from atypically late onset of schizophrenia (SCZ) to Alzheimer's Disease (AD). Despite the clinical necessity of differentiating these conditions to guide effective treatment, achieving an accurate diagnosis remains challenging. This study aimed to utilize data-driven analyses of structural magnetic resonance imaging (MRI) to distinguish between these diagnostic possibilities. Utilizing publicly available datasets of MRI scans from 699 healthy control (HC) participants and 469 patients diagnosed with SCZ or AD, our analysis focused on bilateral subcortical volumetric measures in the caudate, hippocampus, putamen, and amygdala. We first trained an unsupervised K-means clustering algorithm based on SCZ and AD patients and achieved a clustering accuracy of 81 % and an area under curvature (AUC) of 0.79 in distinguishing between these two groups. Subsequently, we calculated the Euclidean distance between the AD and SCZ cluster centroids for each of ten patients with unexplained onset of psychosis after age 45 from a clinical MRI registry. Six patients were classified as AD and four as SCZ. Our findings revealed that among LOP participants, those classified in the SCZ cluster exhibited significantly greater right putamen volumes compared to those in the AD cluster (p < 0.0025). There were also intriguing clinical differences. While we do not have diagnostic biomarker information to confirm these classifications, this study sheds light on the heterogeneity of psychoses in late life and illustrates the potential use of widely available structural MRI and data-driven methods to enhance diagnostic accuracy and treatment outcomes for LOP patients.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115386"},"PeriodicalIF":2.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.bbr.2024.115388
Tania Llana , Marta Mendez , M.-Carmen Juan , Magdalena Mendez-Lopez
Navigational object-location memory (OLM) is a form of spatial memory involving actual or virtual body displacement for repositioning previously encoded objects within an environment. Despite its potential for higher ecological validity measures, navigational OLM has been less frequently assessed than static OLM. The present systematic review aims to characterize the methodology and devices used for OLM assessment in navigational real and virtual environments and synthesize recent literature to offer a comprehensive overview of OLM performance in both pathological and non-pathological adult samples. A search through four different databases was conducted, identifying 39 studies. Most studies assessed navigational OLM in healthy adults by 2-dimensional or 3-dimensional computerized tasks, although immersive Virtual Reality (VR) devices were also frequently employed. Small environments and objects with high-semantic value were predominantly used, with assessment mainly conducted immediately after learning through free-recall tasks. The findings revealed that healthy samples outperformed clinical ones in navigational OLM. Men showed superior performance compared to women when cues or landmarks were used, but this advantage disappeared in their absence. Better results were also noted with shorter intervals between learning and recall. Fewer OLM errors occurred in real environments compared to both immersive and non-immersive VR. Influences of environmental features, object semantics, and participant characteristics on OLM performance were also observed. These results highlight the need for standardized methodologies, the inclusion of a broader age range in populations, and careful control over the devices, environments, and objects used in navigational OLM assessments.
{"title":"Navigational object-location memory assessment in real and virtual environments: A systematic review","authors":"Tania Llana , Marta Mendez , M.-Carmen Juan , Magdalena Mendez-Lopez","doi":"10.1016/j.bbr.2024.115388","DOIUrl":"10.1016/j.bbr.2024.115388","url":null,"abstract":"<div><div>Navigational object-location memory (OLM) is a form of spatial memory involving actual or virtual body displacement for repositioning previously encoded objects within an environment. Despite its potential for higher ecological validity measures, navigational OLM has been less frequently assessed than static OLM. The present systematic review aims to characterize the methodology and devices used for OLM assessment in navigational real and virtual environments and synthesize recent literature to offer a comprehensive overview of OLM performance in both pathological and non-pathological adult samples. A search through four different databases was conducted, identifying 39 studies. Most studies assessed navigational OLM in healthy adults by 2-dimensional or 3-dimensional computerized tasks, although immersive Virtual Reality (VR) devices were also frequently employed. Small environments and objects with high-semantic value were predominantly used, with assessment mainly conducted immediately after learning through free-recall tasks. The findings revealed that healthy samples outperformed clinical ones in navigational OLM. Men showed superior performance compared to women when cues or landmarks were used, but this advantage disappeared in their absence. Better results were also noted with shorter intervals between learning and recall. Fewer OLM errors occurred in real environments compared to both immersive and non-immersive VR. Influences of environmental features, object semantics, and participant characteristics on OLM performance were also observed. These results highlight the need for standardized methodologies, the inclusion of a broader age range in populations, and careful control over the devices, environments, and objects used in navigational OLM assessments.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"Article 115388"},"PeriodicalIF":2.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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