Behavioural Brain Research最新文献_第10页

Corrigendum to “The mechanism of electroacupuncture treatment for post-stroke spasticity: A systematic review and meta-analysis” [Behav. Brain Res. 497 (2026) 115873] 《电针治疗脑卒中后痉挛的机制：一项系统综述和荟萃分析》的更正。中国生物医学工程学报，2015(5):357 - 357。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115897

Lei You , Mengwan Hu , Jingang Li , Jiahui Tan , Fengmin Guo , Ying Kong

引用次数: 0

Individual differences in frequency modulated 50-kHz ultrasonic vocalizations reflect but do not predict cocaine self-administration in rats 频率调制50 khz超声波发声的个体差异反映但不能预测大鼠的可卡因自我给药。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115906

Anna Skórzewska , Karolina Kuchniak , Edyta Wyszogrodzka , Ewa Taracha

Frequency-modulated (FM) 50-kHz ultrasonic vocalizations (USVs) in rats reflect a positive emotional state. The aim of this study was to evaluate whether anticipatory and cocaine-induced FM 50-kHz USVs can predict individual vulnerability to cocaine self-administration behavior. Twenty singly housed rats underwent behavioral testing (elevated plus maze, novel object recognition, and tickling-induced vocalizations) and amphetamine sensitization. The animals then participated in 22 self-administration (SA) sessions (2 days on / 1 day off), during which active nose pokes and FM 50-kHz USVs were recorded during both the anticipatory (cocaine-free) and cocaine phases. Despite pronounced individual differences in SA levels, none of the analyzed behavioral markers predicted SA acquisition. The FM 50-kHz USV response to the first dose of amphetamine showed a bimodal distribution; rats with a weak response exhibited significantly higher levels of cocaine SA. Due to substantial behavioral differences, further analyses were conducted in low-SA and high-SA groups. Anticipatory FM 50-kHz USVs did not correlate with SA intensity and were similarly high in both groups. During the cocaine phase, high-SA rats displayed significantly stronger vocal responses than low-SA rats. FM 50-kHz USVs reflect both contextual and drug-induced positive affect but are highly sensitive to housing conditions and experimental procedures. The response to the first amphetamine dose may serve as a predictive marker of vulnerability to cocaine SA. However, anticipatory FM 50-kHz USVs do not provide a reliable indicator of SA intensity. Accurate interpretation of FM 50-kHz USVs requires integration with behavioral and neurobiological markers to effectively identify addiction risk phenotypes.

调频（FM） 50 khz超声发声（usv）在大鼠反映积极的情绪状态。本研究的目的是评估预期性和可卡因诱导的FM 50-kHz usv是否可以预测个体对可卡因自我给药行为的易感性。20只单独饲养的大鼠进行了行为测试（升高+迷宫，新物体识别和挠痒诱导的发声）和安非他明致敏。然后，这些动物参加了22个自我给药（SA）阶段（2天开/ 1天休息），在此期间，在预期（无可卡因）和可卡因阶段记录活跃的鼻子戳和FM 50-kHz usv。尽管SA水平存在显著的个体差异，但所分析的行为标记都不能预测SA的获得。FM对第一剂量安非他明的50-kHz USV响应呈双峰分布；反应较弱的大鼠表现出明显较高的可卡因SA水平。由于行为学差异很大，我们对低sa组和高sa组进行了进一步的分析。预期调频50-kHz usv与SA强度无关，在两组中同样高。在可卡因阶段，高sa大鼠的声音反应明显强于低sa大鼠。FM 50-kHz usv反映了环境和药物诱导的积极影响，但对住房条件和实验程序高度敏感。对第一剂量安非他明的反应可以作为对可卡因SA易感性的预测标志。然而，预期调频50-kHz usv不能提供SA强度的可靠指标。准确解释FM 50-kHz usv需要与行为和神经生物学标记相结合，以有效识别成瘾风险表型。

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引用次数: 0

PET-measured tau deposition in emotion-related brain regions is differentially associated with depressive symptoms in individuals with versus without Alzheimer’s disease pathology pet测量的情绪相关脑区域的tau沉积与阿尔茨海默病病理与非阿尔茨海默病病理个体的抑郁症状存在差异。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115889

Erika Glaubitz, Xiuyuan Hugh Wang, Ke Xi, Farnia Feiz, Silky Pahlajani, Tom Maloney, Emily Tanzi, Hani Hojjati, Liangong Zhou, Lidia Glodzik, Gloria Chiang, Yi Li, Ray Razlighi, Mony de Leon, Tracy Butler

Depressive symptoms are common in patients diagnosed with Alzheimer’s Disease (AD) and can also precede AD as a risk factor and/or prodrome. Brain deposition of hyper-phosphorylated tau is a hallmark pathology of AD. Tau deposition in brain regions involved in emotional processing is likely to be pathophysiologically relevant to these links between AD and depression. We used 18F-MK6240 PET to measure tau in amygdala, hippocampus, and nucleus accumbens—regions implicated in depression—in 141 participants with and without AD. In addition to tau PET, participants underwent amyloid-beta (Aβ) PET, MRI, and cognitive evaluation. Depressive symptoms were assessed with the Beck Depression Inventory (BDI). Multiple regression analyzed contributions of tau and Aβ status (positive vs. negative), depression (BDI > 13), cognition (impaired vs. normal), age and sex to tau burden in the three regions. A significant interaction between tau status and depression prompted subgroup analyses of tau-positive (n = 34) and tau-negative (n = 107) participants. Among tau-positive participants, depression was associated with greater tau in the nucleus accumbens, a region critical for reward processing and motivation. This finding suggests that tau-mediated accumbens dysfunction may contribute to anhedonia, a key symptom of depression that is particularly common in AD-related depression. In tau-negative participants, greater depression was associated with less tau in the medial temporal lobe. This unexpected finding requires confirmation through further research, but could reflect impaired neurogenesis in depression without AD pathology.

抑郁症状在诊断为阿尔茨海默病（AD）的患者中很常见，也可以作为AD的危险因素和/或前驱症状。脑内过度磷酸化的tau沉积是阿尔茨海默病的标志性病理。参与情绪处理的大脑区域的Tau沉积可能与AD和抑郁症之间的这些联系有病理生理学上的相关性。我们使用18F-MK6240 PET测量141名AD患者和非AD患者杏仁核、海马和伏隔核中与抑郁有关的tau蛋白。除了tau PET外，参与者还接受了β淀粉样蛋白（Aβ） PET、MRI和认知评估。用贝克抑郁量表（BDI）评估抑郁症状。多元回归分析了三个区域tau和Aβ状态（阳性与阴性）、抑郁（BDI bbb13）、认知（受损与正常）、年龄和性别对tau负担的贡献。tau状态和抑郁之间的显著相互作用促使对tau阳性（n=34）和tau阴性（n=107）参与者进行亚组分析。在tau阳性的参与者中，抑郁与伏隔核中较大的tau有关，伏隔核是一个对奖励处理和动机至关重要的区域。这一发现表明，tau介导的伏隔核功能障碍可能导致快感缺乏症，这是抑郁症的一个关键症状，在ad相关抑郁症中尤为常见。在tau阴性的参与者中，更大的抑郁与内侧颞叶中较少的tau相关。这一意想不到的发现需要通过进一步的研究来证实，但可能反映了没有AD病理的抑郁症的神经发生受损。

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引用次数: 0

Ultrasonic calls accompanying affiliative contacts between adult groupmates in two Lasiopodomys vole species 两种Lasiopodomys田鼠成年群体间亲缘接触的超声呼叫

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115903

Ilya A. Volodin , Margarita M. Dymskaya , Antonina V. Smorkatcheva , Elena V. Volodina

Ultrasonic calls (USVs) produced by rodents during contacts with group members are poorly studied compared to USVs elicited by isolation, handling, mate exposition or dyad same-sex interactions on a neutral territory. In this study, we apply a procedure for eliciting the USVs accompanying contacts between adult voles living in permanent social groups for two Lasiopodomys vole species. The values of all variables of fundamental and peak frequencies were significantly higher in L. brandtii than in L. mandarinus, the duration of USVs was two times longer in L. brandtii than in L. mandarinus. At the same time, the USVs did not differ between species in the occurrence of different call contours, nonlinear phenomena and note compositions. The USVs emitted during affiliative contacts were acoustically nearly identical to the low-frequency USVs described previously for these two species in the situation of short-term isolation from conspecifics. We discuss that voles can use the same type USVs in two different situations: of short-term isolation from conspecifics and during affiliative contacts in social groups. Call-eliciting procedure applied in this study is easy and potentially appropriate for pilot and comparative studies of USVs across species, including wild-type rodents without long experience of living under laboratory conditions.

与隔离、处理、配偶暴露或在中立领土上的同性互动引起的超声波呼叫相比，啮齿动物在与群体成员接触时产生的超声波呼叫（usv）研究得很少。在这项研究中，我们应用了一种程序来引出在永久社会群体中生活的两种Lasiopodomys田鼠的成年田鼠之间的接触所伴随的usv。各变量的基频和峰频值均显著高于野田葵，野田葵的usv持续时间是野田葵的2倍。与此同时，不同物种的usv在不同叫声轮廓、非线性现象和音符组成的发生上没有差异。在亲密接触时发出的usv在声学上与之前描述的这两个物种在与同种动物短期隔离的情况下发出的低频usv几乎相同。我们讨论了田鼠可以在两种不同的情况下使用相同类型的usv：与同种动物的短期隔离和在社会群体中的从属接触。本研究中使用的呼叫引出程序很容易，并且可能适用于跨物种的usv试点和比较研究，包括没有长期在实验室条件下生活经验的野生型啮齿动物。

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引用次数: 0

Audiovisual integration of faces and voices in Chinese individuals with social anxiety 中国社交焦虑个体面孔和声音的视听整合

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115905

Jing Yuan , Xianghui Liu , Xiaoli Chen , Mengyi Li , Zejun Liu , Bing Li

In our daily lives, we perceive the emotions of others usually through a variety of modalities such as faces, voices, gestures, etc. However, very few studies have investigated the multisensory integration of emotional information. In the current study, we aimed to explored the audiovisual integration of faces and voices in individuals with social anxiety. In Experiment 1, individuals with social anxiety disorder (SAD) and healthy controls (HCs) participated in an emotion categorisation task using static angry and happy faces and voices. The results showed that for angry emotion, compared to auditory stimuli, the SAD group took shorter to categorise audiovisual stimuli; while the HC group took shorter to categorise audiovisual stimuli than visual stimuli. In Experiment 2, We replaced static faces with dynamic faces. The results showed that facilitation effects of audiovisual integration for angry emotion in both groups. In addition, we found that the SAD group took longer to identify the angry emotion with the audiovisual modality compared to the HC group. However, these effects were only observed for reaction time, not accuracy. Our findings have implications for interventions for social anxiety.

在我们的日常生活中，我们通常通过各种方式感知他人的情绪，如面部、声音、手势等。然而，关于情绪信息的多感官整合的研究却很少。在本研究中，我们旨在探讨社交焦虑个体的面孔和声音的视听整合。在实验1中，患有社交焦虑障碍（SAD）的个体和健康对照（hc）的个体参与了一个使用静态愤怒和快乐面孔和声音的情绪分类任务。结果显示，对于愤怒情绪，与听觉刺激相比，SAD组对视听刺激进行分类的时间更短；而HC组对视听刺激的分类时间比视觉刺激短。在实验2中，我们用动态面代替静态面。结果表明，视听整合对两组愤怒情绪均有促进作用。此外，我们发现与HC组相比，SAD组用视听方式识别愤怒情绪所需的时间更长。然而，这些影响只观察到反应时间，而不是准确性。我们的发现对社会焦虑的干预具有启示意义。

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引用次数: 0

Dynamics of ACC excitatory neurons during reversal learning: Implications for cognitive flexibility 逆向学习过程中ACC兴奋性神经元的动态：对认知灵活性的影响。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-28 DOI: 10.1016/j.bbr.2025.115902

Meng Zhang , Fanzhi Shen , Chongzheng Liao , Shuai Liu , Huimin Wang , Chunxia Li

Cognitive flexibility, a core component of adaptive behavior, enables individuals to adjust their actions when environmental contingencies change and is frequently impaired in neuropsychiatric conditions such as obsessive-compulsive disorder (OCD) and autism spectrum disorder (ASD). The anterior cingulate cortex (ACC), known to support error monitoring, action-outcome evaluation, and rule updating, has been implicated in cognitive flexibility, yet the precise role of its excitatory neurons remains unclear. Using fiber photometry in a touchscreen-based task, we monitored ACC excitatory neuron activity in mice during discrimination and reversal learning to test whether their activity varies across learning stages and relates to behavioral adaptation. By analyzing calcium dynamics in a ± 1-second window around the reward-seeking nosepoke, we found that ACC activity increased significantly during incorrect trials compared to correct trials, specifically in the middle phase of reversal learning. Moreover, the magnitude of ACC activity in both correct and incorrect trials correlated positively with task accuracy and negatively with the number of correction trials, respectively, highlighting a strong link between ACC engagement and adaptive performance during this critical transition phase. These results suggest that ACC excitatory neurons may contribute to performance monitoring and rule updating rather than merely encoding trial outcomes. Together, our findings underscore a temporally specific role for ACC excitatory neurons in cognitive flexibility and may inform future therapeutic strategies targeting ACC-related dysfunction in disorders of behavioral rigidity.

认知灵活性是适应性行为的核心组成部分，它使个体能够在环境突发事件发生变化时调整自己的行为，在强迫症（OCD）和自闭症谱系障碍（ASD）等神经精神疾病中经常受到损害。前扣带皮层（ACC）支持错误监测、行为结果评估和规则更新，与认知灵活性有关，但其兴奋性神经元的确切作用尚不清楚。在基于触摸屏的任务中使用纤维光度法，我们监测了小鼠在辨别和反转学习期间ACC兴奋性神经元的活动，以测试它们的活动是否在学习阶段不同以及与行为适应有关。通过分析奖励鼻突周围±1秒窗口内的钙动力学，我们发现在不正确的实验中，与正确的实验相比，ACC活性显著增加，特别是在反转学习的中期。此外，在正确和错误试验中，前扣带皮层活动的大小分别与任务准确性呈正相关，与纠正试验的次数负相关，这表明在这一关键过渡阶段，前扣带皮层参与与适应性表现之间存在密切联系。这些结果表明，ACC兴奋性神经元可能有助于性能监测和规则更新，而不仅仅是编码试验结果。总之，我们的研究结果强调了ACC兴奋性神经元在认知灵活性中的暂时特异性作用，并可能为未来针对行为僵硬障碍中ACC相关功能障碍的治疗策略提供信息。

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引用次数: 0

The impact of sports experience on map symbol representation in orienteering athletes and its neural correlates: Evidence from eye-tracking and fNIRS 运动经验对定向运动员地图符号表征的影响及其神经关联：来自眼动追踪和近红外光谱的证据。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-28 DOI: 10.1016/j.bbr.2025.115894

Shijia Ou , Limin Guo , Yang Liu , Hongqi Xu

Purpose

This study examined the effects of sports experience on visual attention and brain activity during map symbol representation tasks in orienteering athletes.

Methods

A single-factor between-subjects design (Skill Level: expert vs. novice) was used. Behavioral, visual attention, and brain activity data were collected simultaneously using eye-tracking and functional near-infrared spectroscopy (fNIRS).

Results

Compared to novices, experts exhibited significantly higher accuracy and lower reaction times. Experts also showed lower fixation frequency, reduced saccade amplitude, and more concentrated fixation hotspots. Neural analyses revealed significantly lower activation in the bilateral dorsolateral prefrontal cortex (DLPFC), bilateral temporal cortex, and left parietal cortex in experts, alongside stronger functional connectivity. Saccade amplitude was positively correlated with bilateral DLPFC activation.

Conclusion

High-level orienteering athletes exhibit domain-specific cognitive advantages in map symbol representation tasks. Long-term orienteering map reading training facilitates synergistic interactions between visual and neural information processing.

目的：探讨运动经验对定向运动员在地图符号表征任务中视觉注意和脑活动的影响。方法：采用单因素受试者间设计（技能水平：专家vs新手）。使用眼动追踪和功能近红外光谱（fNIRS）同时收集行为、视觉注意力和大脑活动数据。结果：与新手相比，专家表现出更高的准确性和更短的反应时间。专家还显示，注视频率较低，眼跳幅度降低，注视热点更集中。神经分析显示，专家的双侧背外侧前额叶皮层（DLPFC）、双侧颞叶皮层和左顶叶皮层的激活显著降低，同时功能连通性更强。眼跳振幅与双侧DLPFC激活呈正相关。结论：高水平定向运动员在地图符号表征任务中表现出特定领域的认知优势。长期的定向地图阅读训练促进了视觉和神经信息处理之间的协同作用。

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引用次数: 0

Bidirectional regulatory mechanisms and targeted therapeutic strategies of the microbiota in ischemic stroke 缺血性脑卒中中微生物群的双向调控机制及靶向治疗策略。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-28 DOI: 10.1016/j.bbr.2025.115900

Bingbing Wang , Yibo Jia , Can Zhang, Shenghao Qian, Caizhen Shi, Li Dan, Tianyu Zhai, Yajuan Xue, Bobo Wang

Ischemic stroke (IS) is not only one of the leading causes of various degrees of dysfunction and disability worldwide, but also the third leading cause of death after heart disease and cancer. Due to the short treatment window and limited efficacy, current treatments face significant challenges, highlighting the urgent need for new neuroprotective therapeutic strategies. The microbiota is regarded as a virtual organ of the body, which is divided into microbiota of the intestines, oral cavity, respiratory tract, and reproductive tract according to the colonization site. In recent years, both basic experiments and clinical studies have emphasized the important relationship between microbiota and IS. For many years, the impact of dysbiosis on IS has become an important and active research direction in the fields of biology and medicine. In this review, we focus on the relationship between the microbiota of the intestines, oral cavity, and other related parts and IS, and emphasize the bidirectional mechanism of action between them. In addition, we discuss potential strategies for treating IS that target the microbiota in different parts, aiming to provide new ideas for disease prevention, diagnosis, and treatment.

缺血性中风（IS）不仅是世界范围内各种程度功能障碍和残疾的主要原因之一，也是仅次于心脏病和癌症的第三大死亡原因。由于治疗窗口期短，疗效有限，目前的治疗面临重大挑战，迫切需要新的神经保护治疗策略。微生物群被认为是人体的虚拟器官，根据定植部位分为肠道、口腔、呼吸道和生殖道的微生物群。近年来，无论是基础实验还是临床研究都强调微生物群与IS的重要关系。多年来，生态失调对IS的影响已成为生物学和医学领域一个重要而活跃的研究方向。本文就肠道、口腔等相关部位的微生物群与IS的关系进行综述，并强调它们之间的双向作用机制。此外，我们还讨论了针对不同部位微生物群的治疗IS的潜在策略，旨在为疾病的预防、诊断和治疗提供新的思路。

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引用次数: 0

Deletion of the 5-HT3A receptor reduces behavioral persistence and enhances flexibility 5-HT3A受体的缺失减少了行为的持久性，增强了灵活性。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-27 DOI: 10.1016/j.bbr.2025.115896

Tomoaki Nakazono , Makoto Kondo

The 5-HT3A receptor is the only ionotropic serotonin receptor and has been implicated in cognitive functions, yet its specific role remains unclear. To investigate the contribution of the 5-HT3A subtype, we trained wild-type (C57BL/6 J) and 5-HT3A receptor knockout (KO) (Htr3a−/−) mice across a series of operant conditioning tasks and compared their behavioral performance. Following nose-poke training, both groups underwent a rule-switching task, extinction tests under fixed ratio (FR) and variable ratio (VR) reinforcement schedules, and a progressive ratio (PR) task to assess persistence. We found that 5-HT3A receptor knockout mice exhibited reduced responding during the extinction suggesting diminished behavioral persistence. The PR task result, in which KO mice showed a trend toward reduced responding, also supports this interpretation. Notably, however, knockout mice acquired the new rule in the switching task significantly faster than wild-type controls, indicating enhanced cognitive flexibility. These findings suggest that the 5-HT3A receptor plays a role in regulating the balance between behavioral persistence and flexibility, normally biasing this balance toward persistence under normal physiological conditions. This mechanism may underlie the therapeutic effect of 5-HT3A receptor antagonists in treatment-resistant obsessive-compulsive disorder (OCD).

5-HT3A受体是唯一的嗜离子性血清素受体，与认知功能有关，但其具体作用尚不清楚。为了研究5-HT3A亚型的作用，我们训练野生型（C57BL/6J）和5-HT3A受体敲除（Htr3a-/-）小鼠进行一系列操作性条件反射任务，并比较它们的行为表现。在戳鼻子训练之后，两组都进行了规则转换任务、固定比（FR）和可变比（VR）强化计划下的消光测试，以及渐进比（PR）任务来评估持久性。我们发现5-HT3A受体敲除小鼠在灭绝过程中表现出降低的反应，这表明行为持久性降低。PR任务结果显示，KO小鼠表现出反应降低的趋势，也支持了这一解释。然而，值得注意的是，基因敲除小鼠在切换任务中获得新规则的速度明显快于野生型对照组，表明认知灵活性增强。这些发现表明，5-HT3A受体在调节行为持久性和灵活性之间的平衡中发挥作用，通常在正常生理条件下使这种平衡偏向持久性。这一机制可能是5-HT3A受体拮抗剂治疗难治性强迫症（OCD）的基础。

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引用次数: 0

Multidimensional quantification of pain responses using novel rat pain scale reveals the absence of opioid induced hyperalgesia following chronic contingent and non-contingent morphine exposure in rats 使用新型大鼠疼痛量表对疼痛反应进行多维量化，揭示了大鼠慢性偶然和非偶然吗啡暴露后阿片类药物诱导的痛觉过敏的缺失。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-27 DOI: 10.1016/j.bbr.2025.115892

Joanna Severino Perez , Carmen Dressler , Benjamin Dunham, Angela Harbeck, Ricardo Petrilli Fortuna, Cindy Lam, Brandy Martin, Mathieu E. Wimmer

Opioids are often prescribed to treat chronic and post-operative pain, but there is data to suggest that opioid exposure can lead to hyperalgesia or allodynia, referring to increases in pain sensitivity to painful and innocuous stimuli, respectively. This paradoxical phenomenon has been observed in the clinic as early as the 1800s and has been modeled numerous times in pre-clinical models of opioid exposure. Opioid induced hyperalgesia (OIH), however, has been met with criticism from clinicians and pre-clinical models do not always mirror clinical opioid use. Here, we explore reflexive responses to mechanical stimuli following chronic contingent and non-contingent morphine exposure after 1 day and 1 week of abstinence. The pain responses were quantified using a high-speed videography-based rodent pain scale, machine learning, and mathematical models. This model combines paw kinematics (speed, height, etc.) with nocifensive behaviors (eye grimace, paw shake, etc.) into a single composite pain score. Males did not exhibit OIH following morphine self-administration, and males and females did not exhibit OIH following experimenter-delivered morphine injections. Hargreaves hot plate assay results complement this data, showing no indication of opioid induced hyperalgesia. Numerous pre-clinical models use drug exposure regimens that are incongruent with doses and patterns prescribed to chronic pain and post-operative patients. Thus, the regimen presented in this study strives to mirror patient drug-taking patterns, providing a key model for the exploration of opioid induced hyperalgesia. Thus, our results complement the current clinical literature, where opioid induced hyperalgesia is not always observed consistently in the patient population.

阿片类药物通常用于治疗慢性和术后疼痛，但有数据表明，阿片类药物暴露可导致痛觉过敏或异常性疼痛，分别指对疼痛和无害刺激的疼痛敏感性增加。这种矛盾的现象早在19世纪就在临床中被观察到，并在阿片类药物暴露的临床前模型中被多次模拟。然而，阿片类药物引起的痛觉过敏（OIH）受到了临床医生的批评，临床前模型并不总是反映阿片类药物的临床使用。在这里，我们研究了戒断1天和1周后，慢性偶然和非偶然吗啡暴露对机械刺激的反射反应。疼痛反应通过基于高速录像的啮齿动物疼痛量表、机器学习和数学模型进行量化。该模型将脚爪运动学（速度、高度等）与恶意行为（眼神扭曲、脚爪抖动等）结合成一个单一的复合疼痛评分。男性在吗啡自我给药后没有表现出OIH，男性和女性在实验者注射吗啡后都没有表现出OIH。哈格里夫斯热板试验结果补充了这一数据，显示没有迹象表明阿片类药物引起的痛觉过敏。许多临床前模型使用的药物暴露方案与慢性疼痛和术后患者的剂量和模式不一致。因此，本研究提出的方案力求反映患者的服药模式，为探索阿片类药物诱导的痛觉过敏提供了一个关键模型。因此，我们的结果补充了目前的临床文献，其中阿片类药物引起的痛觉过敏并不总是在患者人群中观察到一致。

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引用次数: 0