Behavioural Brain Research最新文献_第7页

Environmental enrichment partially rescues neurodevelopmental milestone delays in the prenatal VPA rat model of autism spectrum disorders 环境富集在一定程度上挽救了自闭症谱系障碍产前VPA大鼠模型的神经发育里程碑延迟

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-18 DOI: 10.1016/j.bbr.2025.116003

Oussama Duieb, Ayoub Rezqaoui, Soufiane Boumlah, Laila Ibouzine-Dine, Hasnaa Mallouk, Soumia Ed-Day, Aboubaker Elhessni, Abdelhalem Mesfioui

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by early sensorimotor delays, which often precede core social deficits as well as restricted and repetitive behaviors. Environmental enrichment (EE) is a promising behavioral intervention for ASD; however, its potential to prevent these earliest neurodevelopmental disruptions remains unexplored. This study investigated whether sustained EE could prevent early milestone delays in a prenatal valproic acid (VPA) rat model of ASD. Female Wistar rats were housed in standard (SH) or EE conditions for eight weeks, beginning two weeks before conception and continuing through lactation. Dams received a single injection of VPA (500 mg/kg) or saline on gestational day 12.5. Offspring were assessed daily from postnatal day (PND) 1–21 for the acquisition of physical and sensorimotor milestones. EE significantly mitigated VPA-induced delays in a subset of key neurodevelopmental milestones. While EE did not fully normalize development to control levels, a composite neurodevelopmental score revealed that EE significantly attenuated the global impairment induced by VPA. These findings demonstrate that preconception-perinatal EE confers partial protection against functional neurodevelopmental deficits in a predictive ASD model, highlighting its potential as a preventive strategy targeting the earliest manifestations of neurodevelopmental disruption.

自闭症谱系障碍（ASD）是一种以早期感觉运动迟缓为特征的神经发育疾病，通常先于核心社交缺陷以及限制性和重复性行为。环境富集（Environmental enrichment， EE）是一种很有前途的ASD行为干预方法。然而，它预防这些早期神经发育障碍的潜力仍未被探索。本研究探讨了持续的情感表达是否可以预防产前丙戊酸（VPA）大鼠ASD模型的早期里程碑延迟。雌性Wistar大鼠在标准（SH）或EE条件下饲养8周，从受孕前两周开始一直持续到哺乳期。妊娠第12.5天，母鼠单次注射VPA（500 mg/kg）或生理盐水。从出生后（PND） 1-21 每天对后代进行评估，以获得身体和感觉运动里程碑。EE显著减轻了vpa诱导的关键神经发育里程碑子集的延迟。虽然情感表达并没有完全使发育正常化到控制水平，但综合神经发育评分显示，情感表达显著减轻了VPA引起的整体损伤。这些发现表明，孕前-围产期情感表达在预测性ASD模型中对功能性神经发育缺陷提供了部分保护，突出了其作为针对神经发育障碍早期表现的预防策略的潜力。

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引用次数: 0

The effect of chronic stress on sensitivity to dexamethasone treatment of HPA axis gene expression in C57Bl/6 mice 慢性应激对地塞米松治疗C57Bl/6小鼠HPA轴基因表达敏感性的影响。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-16 DOI: 10.1016/j.bbr.2025.116000

Rasha Salman , Polina Ritter , Yuliya Ryabushkina , Julia Khantakova , Natalya Bondar

Chronic social stress is a major risk for psychopathologies such as depression, often leading to altered hypothalamic-pituitary-adrenal (HPA) axis function and glucocorticoid resistance. This study examines how chronic social defeat stress (CSDS) affects sensitivity to dexamethasone by analyzing HPA axis genes expression in C57Bl/6 mice. Adult male mice were subjected to 30 days of stress, followed by dexamethasone or saline administration. Genes expression was analyzed in the hypothalamus, prefrontal cortex (PFC; Nr3c1 only), and adrenal glands at multiple time points post-treatment. CSDS induced marked dysregulation of HPA axis-related genes, including a decrease in hypothalamic Crh and Crhbp, and adrenal Mc2r, Nr3c1, alongside an upregulation of steroidogenic enzymes Cyp11a1 and Cyp11b1, which may account for the elevated corticosterone levels observed under chronic stress conditions. CSDS alters the genes expression response to dexamethasone, indicating a delayed recovery of glucocorticoid receptor signaling in the brain and adrenal glands. Our findings reveal significant stress-induced alterations in the expression of key HPA axis genes, suggesting impaired glucocorticoid receptor signaling and potential glucocorticoid resistance in stressed mice.

慢性社会压力是抑郁症等精神病理的主要风险，经常导致下丘脑-垂体-肾上腺（HPA）轴功能改变和糖皮质激素抵抗。本研究通过分析C57Bl/6小鼠HPA轴基因表达，探讨慢性社会失败应激（CSDS）对地塞米松敏感性的影响。成年雄性小鼠承受30天的应激，随后给予地塞米松或生理盐水。在治疗后多个时间点分析下丘脑、前额皮质（PFC；仅Nr3c1）和肾上腺的基因表达。CSDS诱导HPA轴相关基因的显著失调，包括下丘脑Crh和Crhbp、肾上腺Mc2r、Nr3c1的减少，以及类固醇生成酶Cyp11a1和Cyp11b1的上调，这可能是慢性应激条件下皮质酮水平升高的原因。CSDS改变了对地塞米松的基因表达反应，表明大脑和肾上腺中糖皮质激素受体信号的延迟恢复。我们的研究结果揭示了应激诱导的关键HPA轴基因表达的显著改变，表明应激小鼠糖皮质激素受体信号传导受损和潜在的糖皮质激素抗性。

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引用次数: 0

Inferring agency: A two-stage process from early integration to late differentiation during action-outcome monitoring 推论代理：行动-结果监测中从早期整合到后期分化的两阶段过程。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-14 DOI: 10.1016/j.bbr.2025.115999

Yunyun Chen , Xintong Zou , Jianxin Zhao , Xuemin Zhang

Inferring agency—the experience of controlling one’s own actions and their consequences—often relies on integrating cues from multiple sources, and recent studies have highlighted the importance of considering the temporal dynamics of this integration process. While previous research has examined how the presence or absence of agency (i.e., reliable versus unreliable sensorimotor cues) affects the neural processing of action-outcomes, it remains unclear whether sensorimotor cues influence this processing dynamically or statically, and how these neural changes relate to explicit judgments of agency. In the present study, participants performed a task in which they moved a ball to a target position under varying motion fluency conditions and then received social feedback regarding their performance, followed by an agency judgement task. Electroencephalography was recorded to capture neural responses during feedback processing. Analyses revealed a dynamic interaction between motion fluency and feedback valence on both the feedback-related negativity (FRN) and explicit agency ratings. Under disfluent motion, the influence of social feedback on both neural responses and agency ratings intensified over time. In contrast, under fluent motion, the influence of social feedback diminished over time. Additionally, FRN was associated with the integration of fluency and feedback, whereas the later P3 component was primarily associated with the influence of fluency on agency ratings. These results indicated that the reflective agency during outcome monitoring could involve an early integration and later differentiation of cues, with the early phase integrating both the sensorimotor and external cues, and the later phase focusing on a more in-depth processing of sensorimotor cues.

推理代理——控制自己的行为及其后果的经验——通常依赖于整合来自多个来源的线索，最近的研究强调了考虑这种整合过程的时间动态的重要性。虽然以前的研究已经研究了代理的存在或缺失（即可靠的或不可靠的感觉运动线索）如何影响动作结果的神经加工，但仍然不清楚感觉运动线索是动态还是静态地调节这种加工，以及这些神经变化如何与代理的显式判断相关。在本研究中，参与者完成了一项任务，在不同的运动流畅性条件下，他们将一个球移动到目标位置，然后收到关于他们表现的社会反馈，随后是一个代理判断任务。记录脑电图以捕捉反馈处理过程中的神经反应。分析结果表明，运动流畅性与反馈效价在反馈相关负性评分和外显代理评分上均存在动态交互作用。在非流畅运动下，社会反馈对神经反应和代理评级的影响随时间而增强。相比之下，在流畅的运动中，社会反馈的影响随着时间的推移而减弱。此外，FRN与流利度和反馈的整合有关，而后一个P3成分主要与流利度对代理评分的影响有关。这些结果表明，结果监测过程中的反射代理可能涉及到线索的早期整合和后期分化，其中早期阶段整合感觉运动和外部线索，后期阶段侧重于对感觉运动线索的更深入加工。

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引用次数: 0

Vitamin D3 supplementation reverses aging-related changes in cholinergic functions and improves spatial memory in aged rats 补充维生素D3可以逆转衰老相关的胆碱能功能变化，并改善老年大鼠的空间记忆。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-14 DOI: 10.1016/j.bbr.2025.115998

Elif Aksoz , Medine Karabulut , Mustafa Hilmi Yaranoğlu

Aim

Dietary intake and synthesis of vitamin D synthesis decline with age, increasing the risk of vitamin D deficiency. Dementia and Alzheimer's disease development are closely linked to vitamin D deficiency. In this study, we investigated whether vitamin D supplementation could attenuate age-related effects on memory and the hippocampal cholinergic system in aged rats.

Method

Thirty Wistar albino male rats (young: 4–5 months old, aged: 21–22 months old) were included in this study. Animals were divided into three groups: The Young control and the Aged control groups were administered physiological serum and the Aged + Vitamin D group was administered vitamin D (500 IU/kg/day). Spatial memory was assessed with the Morris Water Maze test. Then, ACh level and ChAT, AChE, and BChE enzyme activities in the hippocampus were examined.

Results

Vitamin D supplementation given to aged rats increased the AchE and BuChE enzyme activities and ACh levels which decreased with aging. The activity of the ChAT enzyme did not change in the aged group, and vitamin D supplementation did not affect it. Increased hippocampal cholinergic transmission improved the spatial memory of aged rats in the MWM test.

Conclusion

Vitamin D supplementation improved spatial memory in rats, probably by reversing the aging-related changes in brain cholinergic functions. Vitamin D shows promise in delaying cognitive decline associated with aging and AD.

目的：膳食中维生素D的摄入量和合成量随着年龄的增长而下降，增加了维生素D缺乏的风险。痴呆症和阿尔茨海默病的发展与维生素D缺乏密切相关。在这项研究中，我们研究了维生素D补充剂是否可以减轻老年大鼠记忆和海马胆碱能系统的年龄相关影响。方法：选用Wistar白化雄性大鼠30只，龄4 ~ 5月龄，龄21 ~ 22月龄。将动物分为3组：年轻对照组和老年对照组给予生理血清，老年+维生素D组给予维生素D （500 IU/kg/ D）。空间记忆采用Morris水迷宫测试。然后检测海马组织中乙酰胆碱（ACh）水平和ChAT、AChE、BChE酶活性。结果：老龄大鼠补充维生素D可提高乙酰胆碱酯酶和BuChE酶的活性，并可降低乙酰胆碱酯酶的含量。老年组的ChAT酶活性没有变化，补充维生素D对其没有影响。海马胆碱能传递增加可改善老年大鼠的空间记忆。结论：补充维生素D可以改善大鼠的空间记忆，可能是通过逆转脑胆碱能功能的衰老相关变化。维生素D有望延缓与衰老和阿尔茨海默病相关的认知能力下降。

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引用次数: 0

Enhancement of cognitive behavior and hippocampal neural oscillations by rhythmic unipolar pulsed magnetic stimulation in 5xFAD Alzheimer's disease mice 节律性单极脉冲磁刺激对5xFAD阿尔茨海默病小鼠认知行为和海马神经振荡的增强

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-13 DOI: 10.1016/j.bbr.2025.115995

Xuting Wang , Xue Wang , Chuncheng Zhao , Haoyu Zhao , Pingping Wang , Tao Song

Alzheimer's disease (AD) imposes a heavy burden on families and society. Rhythmic magnetic stimulation has emerged as a promising non-invasive therapy to mitigate AD-related cognitive decline. In this study, we applied a rhythmic unipolar compound pulsed magnetic field (cPMF; carrier frequency: 40 Hz, repetition rate: 5 Hz, magnetic flux density: 0–20 mT) incorporating both theta and gamma rhythms to evaluate its effects on behavior and neural oscillations in AD mice and to explore the underlying mechanisms. 5xFAD mice received unipolar cPMF stimulation for 1 h/d over 8 consecutive weeks. Learning and memory were assessed using the novel object recognition (NOR) and the Morris water maze (MWM) tests. In NOR test, unipolar cPMF-treated mice showed a higher cognitive index in test phase 2, and in MWM test, exhibited shorter escape latencies in the training trial and spent less time to first cross the precise former platform location with a higher crossing frequency over this target area in the probe trial. Local field potentials (LFPs) in the hippocampal CA1 area were recorded via in vivo electrophysiology. LFP analysis showed that unipolar cPMF treatment enhanced power of cognitive-related neural oscillations and strengthened theta-gamma phase-amplitude coupling. RNA sequencing analysis further indicated that unipolar cPMF-treated mice exhibited differential gene expression in molecular function and multiple neurotransmitter synaptic signaling pathways. In conclusion, unipolar cPMF might improve cognitive function in 5xFAD mice by modulating cognitive-related neural oscillations. These findings could provide experimental support for the low-intensity pulsed magnetic stimulation as a potential therapeutic strategy for AD.

阿尔茨海默病给家庭和社会带来了沉重的负担。有节奏的磁刺激已成为一种有前途的非侵入性治疗，以减轻ad相关的认知能力下降。在这项研究中，我们应用了一个有节奏的单极复合脉冲磁场（cPMF，载频：40Hz，重复频率：5Hz，磁通量密度：0-20 mT）结合theta和gamma节律来评估其对AD小鼠行为和神经振荡的影响，并探讨其潜在机制。5xFAD小鼠接受单极cPMF刺激1h/d，连续8周。采用新目标识别（NOR）和Morris水迷宫（MWM）测试评估学习和记忆。在NOR测试中，单极cpmf处理的小鼠在测试第二阶段表现出更高的认知指数，在MWM测试中，在训练试验中表现出更短的逃避潜伏期，在探针试验中首次穿过精确的前平台位置的时间更短，穿过该目标区域的频率更高。在体电生理方法记录海马CA1区的局部场电位（lfp）。LFP分析显示，单极cPMF治疗增强了认知相关神经振荡的强度，增强了theta-gamma相位振幅耦合。RNA测序分析进一步表明，单极cpmf处理小鼠在分子功能和多种神经递质突触信号通路上表现出差异基因表达。综上所述，单极cPMF可能通过调节认知相关神经振荡来改善5xFAD小鼠的认知功能。这些发现可以为低强度脉冲磁刺激作为一种潜在的治疗策略提供实验支持。

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引用次数: 0

Beyond the undermining effect: Extrinsic rewards preserve neural intrinsic reward 超越破坏效应：外在奖励保护神经内在奖励。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-13 DOI: 10.1016/j.bbr.2025.115996

Hiroaki Ayabe , Takahiko Koike , Ayumi Yoshioka , Satoshi Izuno , Kanae Ogasawara , Shohei Tsuchimoto , Norihiro Sadato

The Self-Determination Theory posits that extrinsic reward withdrawal often undermines intrinsic motivation. This undermining effect varies according to the reward category (e.g., monetary vs. praise). However, the mechanism underlying this variability remains unclear, partly because previous studies have conceptualized intrinsic motivation as a single construct without distinguishing liking (intrinsic value) from wanting (motivational drive). Failure to make this distinction may obscure the effects of rewards on each component. We hypothesized that extrinsic reward withdrawal would differentially affect intrinsic value and motivational drive. To test this hypothesis, we conducted functional magnetic resonance imaging (fMRI) on 54 participants who were randomly assigned to one of three conditions: control (no rewards), monetary reward, or social reward. Participants in the monetary and social reward groups played a stopwatch game twice, first with and then without extrinsic rewards. The control group received no extrinsic rewards during the task. We assessed intrinsic value through fMRI-measured activation of the reward system and motivational drive through voluntary engagement during the task intermission. Intrinsic value, measured by activation in predefined reward-related regions, declined in the control group but was preserved in both extrinsic reward groups after withdrawal. Thus, both monetary and social rewards were associated with preserved intrinsic value. However, intrinsic behavioral motivation declined in the monetary group but was maintained in the social group. These findings suggest that extrinsic reward withdrawal differentially influences intrinsic value and motivational drive across reward categories, thereby clarifying the variability of the undermining effect.

自我决定理论认为，外在奖励的退缩往往会破坏内在动机。这种破坏效应因奖励类别而异（例如，金钱vs.赞美）。然而，这种差异背后的机制尚不清楚，部分原因是先前的研究将内在动机概念化为单一结构，没有区分喜欢（内在价值）和想要（动机驱动）。如果不能区分这一点，奖励对每个组成部分的影响就会变得模糊。我们假设外在奖励退缩会对内在价值和动机驱动产生不同的影响。为了验证这一假设，我们对54名参与者进行了功能性磁共振成像（fMRI），他们被随机分配到三种情况中的一种：控制（没有奖励）、金钱奖励或社会奖励。金钱奖励组和社会奖励组的参与者玩了两次秒表游戏，第一次有外部奖励，然后没有。对照组在任务过程中没有获得任何外部奖励。我们通过fmri测量奖励系统的激活和任务间歇期间自愿参与的动机驱动来评估内在价值。内在价值，通过预先定义的奖励相关区域的激活来测量，在对照组中下降，但在退出后，两个外在奖励组都保持不变。因此，货币和社会奖励都与保留的内在价值有关。然而，内在行为动机在货币组中有所下降，而在社会组中则保持不变。这些研究结果表明，外在奖励退缩对不同奖励类别的内在价值和动机驱动的影响是不同的，从而阐明了破坏效应的可变性。

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引用次数: 0

Neurophysiological correlates of reward and punishment feedback processing in individuals with test anxiety 考试焦虑个体奖惩反馈加工的神经生理学相关性。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-12 DOI: 10.1016/j.bbr.2025.115991

Yuhong Ou , Renlai Zhou

Understanding how individuals with high test anxiety (HTA) process evaluative feedback is essential to clarifying their responses in evaluative situations. This study examined how individuals with HTA differ from those with low test anxiety (LTA) in processing positive and negative outcomes presented in reward and punishment contexts. Using event-related potentials (ERPs) and a probabilistic learning task, we implemented separate reward and punishment blocks with test-related and test-unrelated images.

Behavioral results indicated that, across reward and punishment blocks, both HTA and LTA individuals responded more quickly and accurately as the task progressed, with no significant performance differences between the groups. ERP findings revealed no deficits in reward processing for individuals with HTA. However, during punishment processing, HTA individuals showed smaller feedback-related negativity (FRN) and larger late positive potential (LPP) amplitudes in response to negative feedback for test-related stimuli. They also exhibited larger FRN amplitudes after positive feedback for test-related stimuli, while no significant group differences were observed in P3 or LPP amplitudes. These findings suggest altered neural responses to evaluative feedback in individuals with HTA, particularly under punitive conditions, which may reflect differences in expectancy and emotional engagement.

了解高考试焦虑（HTA）个体如何处理评估性反馈对于澄清他们在评估情境中的反应是至关重要的。本研究考察了HTA个体与低测试焦虑个体（LTA）在处理奖惩情境中呈现的积极和消极结果方面的差异。利用事件相关电位（erp）和概率学习任务，我们实现了带有测试相关和测试无关图像的单独奖惩块。行为结果表明，在奖励和惩罚块中，随着任务的进行，HTA和LTA个体的反应都更快、更准确，两组之间没有显著的表现差异。ERP结果显示，HTA患者在奖励处理方面没有缺陷。然而，在惩罚加工过程中，HTA个体对测试相关刺激的负反馈反应表现出较小的反馈相关负性（FRN）和较大的后期正电位（LPP）振幅。他们在测试相关刺激的正反馈后也表现出更大的FRN振幅，而在P3或LPP振幅上没有观察到显著的组差异。这些发现表明，HTA患者对评价反馈的神经反应发生了改变，特别是在惩罚性条件下，这可能反映了期望和情感投入的差异。

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引用次数: 0

Beyond the road not taken: Experienced regret-induced risk seeking in maximizers 超越未走的路：在最大化者中经历过后悔诱导的风险寻求。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-12 DOI: 10.1016/j.bbr.2025.115992

Shuai Jin , Xue Wei , Peihua Xian , Junshu Ma , Shenghao Shi , Zhiyuan Liu

Given the complexity of the environment and the constraints on cognitive resources, missed opportunities frequently arise in risky decision-making. However, the relationship between regret feelings for missed opportunities and subsequent risky decision-making among maximizers, as well as the influence of time pressure on this dynamic, remains unclear. Based on 580 participants, we conducted a cross-sectional survey and two EEG experiments to investigate these issues. The results revealed a positive correlation between maximization and risk-taking tendency (Study 1). Compared to satisficers, maximizers showed stronger regret feelings and increased the late positive potential (LPP) amplitudes in response to missed opportunities, and were more inclined to engage in risky decisions. Moreover, maximizers’ regret feelings about missed opportunities facilitated their risky decision-making by amplifying LPP amplitudes (Study 2). Compared to the low-time-pressure condition, maximizers exhibited diminished regret feelings and reduced LPP amplitudes in response to missed opportunities, and less risky decision-making behavior under the high-time-pressure condition. Additionally, time pressure attenuated the association between regret feelings for missed opportunities and risky decision-making (Study 3). Overall, this study highlights that maximizers’ regret feelings about missed opportunities drive them to take risky decision-making, and time pressure can reduce the degree to which this occurs.

考虑到环境的复杂性和认知资源的限制，在高风险决策中经常会出现错失机会的情况。然而，对错失机会的后悔情绪与最大化者随后的冒险决策之间的关系，以及时间压力对这种动态的影响，目前尚不清楚。基于580名参与者，我们进行了横断面调查和两次脑电图实验来研究这些问题。结果显示，最大化与冒险倾向呈正相关（研究1）。与满足者相比，最大化者在错失机会时表现出更强烈的后悔情绪，并增加了后期积极电位（LPP）振幅，更倾向于从事风险决策。此外，最大化者对错失机会的后悔情绪通过放大LPP振幅促进了他们的风险决策（研究2）。与低时间压力条件下相比，在高时间压力条件下，最大化者对错失机会的后悔情绪和LPP振幅有所减少，风险决策行为也有所减少。此外，时间压力减弱了错失机会的后悔情绪与冒险决策之间的联系（研究3）。总的来说，这项研究强调了最大化者对错过机会的后悔情绪驱使他们做出冒险的决策，而时间压力可以降低这种情况发生的程度。

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引用次数: 0

Cognitive styles diversity and group creativity: Evidence from fNIRS hyperscanning 认知风格多样性与群体创造力：来自近红外超扫描的证据。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-11 DOI: 10.1016/j.bbr.2025.115986

Liu Ning , Ou Yang Yan Ping , Ren Sai Nan

This study explores how cognitive style diversity (differences in information processing among team members) influences group creativity through interpersonal neural mechanisms. 116 college students were assigned to high-diversity (HD) groups (mix of field-independent and field-dependent individuals) or low-diversity (LD) groups (homogeneous cognitive styles). Both groups completed a creative task (umbrella design) and a routine task (desk purchase) while their prefrontal cortex (PFC) and right temporoparietal junction (r-TPJ) activity was monitored via fNIRS. Results revealed that HD groups produced significantly more novel ideas than LD groups. fNIRS data showed enhanced brain synchronization in HD groups within the frontal pole and dorsolateral prefrontal cortex (DLPFC). Field-independent individuals dominated neural interactions in HD groups, with delayed inter-brain synchronization positively correlating with creative novelty. Findings suggest cognitive diversity fosters group creativity through complementary neural coordination between field-independent and field-dependent individuals.

本研究探讨认知风格多样性（团队成员之间信息加工的差异）如何通过人际神经机制影响团队创造力。116名大学生被分为高多样性（HD）组（领域独立和领域依赖个体的混合）和低多样性（LD）组（同质认知风格）。两组都完成了一项创造性任务（设计雨伞）和一项常规任务（购买书桌），同时通过近红外光谱监测他们的前额叶皮层（PFC）和右颞顶叶交界处（r-TPJ）的活动。结果显示，HD组比LD组产生了更多的新想法。fNIRS数据显示，HD组在额极和背外侧前额叶皮层（DLPFC）内的大脑同步增强。在HD组中，场独立个体主导着神经相互作用，延迟的脑间同步与创造性新颖性正相关。研究结果表明，认知多样性通过领域独立和领域依赖个体之间的互补神经协调来促进群体创造力。

引用次数: 0

Tracking the developing brain: Resting-state aperiodic activity reveals nonlinear cortical maturation in externalizing disorders 追踪发育中的大脑：静息状态的非周期性活动揭示外化障碍中的非线性皮层成熟。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-12-11 DOI: 10.1016/j.bbr.2025.115994

Hongchi Zhang , Amir Jahanian-Najafabadi , Khaled Bagh , Lorenza Colzato , Bernhard Hommel

Previous research has linked psychiatric disorders to alterations in the aperiodic exponent—a measure of excitatory–inhibitory (E/I) balance derived from resting-state EEG that reflects broadband, non-oscillatory brain activity. This measure also appears sensitive to age-related neurodevelopmental changes. In this study, we investigated whether the aperiodic exponent varies with age in children and adolescents diagnosed with adjustment disorder (AD) or oppositional defiant disorder (ODD), compared to age-matched healthy controls. While healthy participants showed no significant association between age and the aperiodic exponent, both clinical groups exhibited a pronounced nonlinear relationship. Specifically, the exponent was lower in early childhood and early adulthood, but peaked around 9–10 years of age. This U-shaped developmental trajectory suggests a deviation from normative brain maturation in AD and ODD and points to temporally specific alterations in cortical E/I balance. These findings underscore the potential of the aperiodic exponent as a developmentally sensitive neural marker of externalising psychopathology and may inform age-tailored diagnostic and intervention strategies in child and adolescent psychiatry.

先前的研究已经将精神疾病与非周期指数的改变联系起来，非周期指数是一种来自静息状态脑电图的兴奋-抑制（E/I）平衡的测量，反映了宽带、非振荡的大脑活动。这一指标似乎对与年龄相关的神经发育变化也很敏感。在这项研究中，我们调查了被诊断为适应障碍（AD）或对立违抗障碍（ODD）的儿童和青少年与年龄匹配的健康对照相比，非周期指数是否随年龄变化。虽然健康的参与者在年龄和非周期指数之间没有显著的关联，但两个临床组都表现出明显的非线性关系。具体来说，该指数在儿童早期和成年早期较低，但在9至10岁左右达到峰值。这种u型发育轨迹表明AD和ODD患者偏离了正常的大脑成熟，并指出了皮层E/I平衡的暂时特异性改变。这些发现强调了非周期性指数作为外化精神病理的发育敏感神经标志物的潜力，并可能为儿童和青少年精神病学的年龄定制诊断和干预策略提供信息。

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