Behavioural Brain Research最新文献_第4页

The effect of caffeine in a model of schizophrenia-like behavior induced by MK-801 in mice

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-06 DOI: 10.1016/j.bbr.2025.115468

Kübra Akıllıoğlu , Seda Köse Korkmaz , Meltem Dönmez Kutlu

Objective

The blockade of NMDA receptors during early developmental stages is accepted as a model for schizophrenia-like behavior. This study aimed to investigate the effects of caffeine on adult behaviors in mice subjected to tests of schizophrenia-like behaviors induced by the NMDA receptor antagonist MK-801.

Materials and methods

MK-801 (0.25 mg/kg, twice daily, 0.1 ml/10 g body weight, intraperitoneally) was administered to Balb/c mice during PND 7–10 to establish a schizophrenia-like behavior model. In one group, caffeine (10 mg/kg, twice daily, 0.1 ml/10 g body weight, intraperitoneally) was given 30 min after MK-801 administration. In another group, MK-801 was administered 30 min after caffeine injection. At 8–10 weeks of age, behavioral tests were performed sequentially: open field test (OFT), elevated plus maze test (EPM), Morris water maze test (MWM), and social interaction test.

Results

MK-801 administration significantly increased anxiety-like behaviors and decreased exploratory behavior in the OFT by reducing the time spent in the center, the frequency of center entries, and rearing frequency, while increasing the latency to the first center entry. In the EPM, MK-801 significantly decreased the time spent in the open arms, the frequency of open arm entries, and the head-dipping behavior of the open arm while increasing the time spent in the closed arms and the latency to the first open arm entry. In the MWM, MK-801 impaired learning and memory performance. MK-801 reduced social interaction. Caffeine reversed the anxiety, social interaction, learning, and memory impairments caused by MK-801.

Conclusion

MK-801 administration during the neonatal period induces schizophrenia-like behaviors in adulthood, whereas low-dose caffeine can mitigate these effects.

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引用次数: 0

EEG microstate as a biomarker of personalized transcranial magnetic stimulation treatment on anhedonia in depression

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-05 DOI: 10.1016/j.bbr.2025.115463

QiangYan Che , Chunhua Xi , Yunlin Sun , Xingyu Zhao , Lei Wang , Ke Wu , Junyu Mao , Xinyu Huang , Kai Wang , Yanghua Tian , Rong Ye , Fengqiong Yu

Anhedonia, a core feature of major depressive disorder (MDD), presents significant treatment challenges with conventional methods. Circuit-targeted, personalized repetitive transcranial magnetic stimulation (rTMS) has shown potentiation by focusing on disruptions in specific networks related to anhedonia. However, how rTMS modulates brain network dynamics in anhedonia is not yet fully understood. This research sought to explore these effects using EEG microstate analysis. In this double-blind, randomized, sham-controlled study, resting-state functional MRI was employed to pinpoint the left dorsolateral prefrontal cortex (DLPFC) region that exhibited the strongest functional connectivity to the nucleus accumbens (NAcc), used as the target for rTMS stimulation. Rest-state EEG data from 49 depressive patients with anhedonia(active=26, sham=23) were analyzed both at baseline and after treatment. In addition, a group of 15 healthy participants was included to serve as baseline controls. Resting-state EEG data were collected at baseline and post-treatment. Using polarity-insensitive k-means clustering, EEG microstates were segmented into five categories (A-E). Circuit-targeted rTMS significantly alleviated symptoms of anhedonia and depression. Compared to healthy controls, patients with anhedonia showed reduced microstate B and C occurrence, along with increased microstate D duration. After rTMS targeting the DLPFC-NAcc pathway, the active treatment group exhibited normalization of microstate C occurrence and a reduction in microstate E duration. Notably, the increase in microstate C was significantly correlated with improvements in anticipatory anhedonia, and these changes were observed specifically in treatment responders. The findings suggest that microstate C is linked to anhedonia and could serve as a reliable biomarker for personalized rTMS treatment. These results provide insights into the neural mechanisms underlying rTMS for anhedonia and highlight the potential of EEG microstate analysis in guiding personalized treatment strategies for depression.

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引用次数: 0

Schrödinger’s cat and mouse: An adapted thought experiment for the context of consciousness

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-03 DOI: 10.1016/j.bbr.2025.115459

Eamonn Eeles , Dana Pourzinal , Jalal Baland , Julian Ray

Consciousness, at its simplest, represents awareness of self in relation to the outside world. This can be divided further into the reasoning and rationality of Access consciousness (A-C) versus the experiential and ‘what it’s like’ of Phenomenal consciousness (P-C). A-C is directly measurable, using standard tests of cognition and memory. However, owing to the subjective nature of P-C, its direct testability remains problematic. We have previously derived indirect measures of P-C that incorporates a combination of subjective questions that are informed by objective dimensions of A-C. This battery of questions have shown sound proof of principle but have not yet been fully tested in the clinical space. As a bridge to clinical validation and in the challenge of a quantification gap, a thought experiment (TE) provides supporting evidence from the philosophy of science. We propose testing the foundational principles upon which operationalization of P-C questions has been designed through the prism of such a TE. We identified that a late-stage theory confirmation type of TE was appropriate for context. In the absence of suitable candidate TEs from cognitive science, we explored adaptation of a classical thought experiment from quantum physics. The ‘Schrödinger’s cat’ TE was refined for purpose into a novel ‘Schrödinger’s cat and mouse’ TE. Using this novel TE, our stated theories on consciousness, specifically P-C, and means of testing resonate with disorders of consciousness, not least delirium.

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引用次数: 0

Effects of neonatal N-methyl-D-aspartate receptor blockade on social facilitation of feeding behavior in adult rats

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-02-02 DOI: 10.1016/j.bbr.2025.115464

Hiroki Furuie , Masatoshi Ukezono , Takashi Okada , Mitsuhiko Yamada

Glutamate and one of its ionotropic receptor subtypes, N-methyl-D-aspartate (NMDA) receptors, are essential for brain development after birth. Rats that underwent NMDA receptor blockade during the neonatal period have been validated as models of schizophrenia. Social facilitation, a phenomenon where an individual’s performance is promoted in the presence of others, reflects the ability to regulate behavior depending on social situations and is likely to be disrupted in schizophrenia. This study investigated the effects of neonatal treatment with MK-801, an NMDA receptor antagonist, on the social facilitation of feeding behavior in adult rats. Under noncompetitive conditions, SAL-treated control rats showed increased food intake when feeding with another rat, whereas MK-801-treated rats did not. Under competitive conditions, SAL-treated rats tended to feed more in the presence of a competitor compared to feeding alone. In contrast, MK-801-treated rats exhibited a significant reduction in food intake in the presence of a competitor. Thus, MK-801-treated rats demonstrated a lack of social facilitation under noncompetitive conditions and social inhibition under competitive conditions. These findings suggest that neonatal NMDA receptor blockade disrupts the ability of rats to regulate their behavior depending on their social situation. Our findings may provide new insights into the social deficits associated with schizophrenia and their underlying mechanisms.

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引用次数: 0

Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-30 DOI: 10.1016/j.bbr.2025.115458

Bo Wang, Peijie Liu, Xinhui Gao, Fengqi Yang, Jiarui Sun, Fengqin He

Background

Maternal behavior is a complex form of social conduct exhibited, which directly influences the brain development and emotional behavior of offspring. Studies have shown that stress significantly impacts maternal behavior, with the 5-HT (serotonin) system playing a crucial role in this process

Objective

This study aims to explore the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress, and to analyze the molecular mechanisms involved

Methods

Sprague-Dawley rats were divided into control, stress, and stress+omega-3 (500 mg/kg) groups. Depressive behaviors were assessed using the sucrose preference test and forced swimming test. The regulatory effects of Omega-3 on maternal behavior following stress were analyzed by measuring 5-HT levels, 5-HT receptors, 5-HT1A receptor expression, downstream cAMP levels, inflammatory markers (IL-1β, TNF-α, and IL-6), and oxidative stress responses (MDA levels)

Results

The stress group exhibited significant reductions in maternal behaviors, such as delayed pup retrieval and decreased licking time. Omega-3 supplementation effectively improved these abnormalities, enhancing maternal care and reducing violent behaviors. Mechanistically, omega-3 supplementation increased 5-HT and receptor expression, reduced inflammation and oxidative stress, and promoted neuronal function recovery

Conclusion

Omega-3 fatty acids can effectively mitigate the negative impact of chronic stress on maternal behavior. The underlying mechanisms involve the regulation of the 5-HT system and the reduction of neuroinflammation. This finding provides a theoretical basis for clinical interventions targeting stress-related maternal behavior disorders.

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引用次数: 0

Environmental enrichment induces depressive- and anxiety-like behaviors in male Balb/C mice

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-30 DOI: 10.1016/j.bbr.2025.115462

Malcon Carneiro de Brito, Beatriz Yamada Costa, Thiago Amorim de Souza Lima, Rosana Camarini

Depression and anxiety disorders are prevalent neuropsychiatric conditions worldwide that impose substantial economic and social burdens worldwide. Environmental enrichment (EE) has been employed to investigate how the environment can influence these disorders. While EE is known to mitigate depressive and anxiety phenotypes across various mouse strains, the Balb/C strain exhibits greater sensitivity to different environmental stimuli. In this study, we aimed to assess the long-term effects of EE introduced after weaning on emotional behaviors in adulthood. Balb/C mice were weaned on postnatal day (PND) 21 and exposed to chronic EE for 3, 12, or 24 hours daily until PND 66. Depressive- and anxiety-like behaviors were assessed using the open field, elevated plus maze, and tail suspension tests, along with measurements of corticosterone plasma levels. EE exposure induced emotional dysregulation, evidenced by an increase in anxiety- and depressive-like behaviors. Shorter length of EE (3 h) had less impact on these behaviors compared to longer periods (12 and 24 h). These findings highlight the need for caution when employing the Balb/C strain in EE models, particularly in studies exploring emotional behaviors.

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引用次数: 0

Context-dependency of vicarious extinction learning

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-30 DOI: 10.1016/j.bbr.2025.115461

Armin Zlomuzica , Friederike Raeder , Sarah Reher , Miriam Lange , Ekrem Dere

Background and objectives

It is well documented that the fear of specific stimuli and situations can be acquired through the social observation of the actions of another person. In contrast, it is still a matter of debate, whether processes related to fear attenuation, extinction, and extinction-retrieval can equally be achieved through social observation after de novo fear conditioning.

Methods

Here, we used a differential fear conditioning procedure and investigated whether the variation of the context of video-based vicarious extinction learning (VEL) will affect subsequent extinction learning and extinction-retrieval. Conditioned fear acquisition, extinction, and extinction-retrieval was measured using psychophysiological (skin conductance responses) and subjective measures (CS-UCS contingency ratings and CS-valence ratings).

Results

Participants showed enhanced fear extinction learning after VEL as compared to controls. VEL improved extinction learning relative to controls but appeared to be highly context-dependent. The beneficial effect of VEL on subsequent extinction learning was abolished when the context in which the model was performing in the video was different from the context in which the observer performed all stages of the experiment.

Limitations

Data were obtained in a non-clinical sample which does not permit the extrapolation of findings to clinical populations.

Conclusion

Our results suggests that safety information derived from VEL promotes fear extinction when model and observer perform the experiment in the same context. Given that fear extinction is considered as an experimental proxy of exposure therapy, our findings might be instructive for the development of novel clinical interventions to promote exposure treatment efficacy.

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引用次数: 0

The role of the intraparietal sulcus in numeracy: A review of parietal lesion cases

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-30 DOI: 10.1016/j.bbr.2025.115453

Erin Duricy , Corrine Durisko , Julie A. Fiez

Prominent theories of numeracy link the intraparietal sulcus (IPS) to approximate representations of quantity that undergird basic math abilities. The goal of this review is to better understand the neural basis of mathematical cognition through the lens of acalculia, by identifying numeracy-focused single case studies of patients with parietal lesions and testing for causal relationships between numeracy impairments and the locus of parietal damage. A systematic literature review identified 27 single case studies with left parietal lesions and categorized administered tasks across four numeracy domains: Approximation, Calculation, Ordinality/Cardinality, and Transcoding. We compared published lesion images by drawing a sphere at the inferred center-of-mass and assigning each case to an anatomical group (IPS or Other Parietal damage) based on overlap with left IPS and original anatomical description. We performed Fisher’s Exact Test to compare behavioral performance on each numeracy domain between the two groups. As an exploratory follow-up, we used Activation Likelihood Estimation (ALE) to identify sites of damage within parietal cortex preferentially associated with impairments in each domain. We found that Approximation impairments were significantly more frequent in the IPS group (p = .003). The exploratory ALE analysis revealed that only Approximation impairment cases significantly overlapped with the IPS, while impairments in other domains were localized to different regions of the parietal lobe. Based on the pattern of impairments shown across these cases, we conclude that damage to the left IPS is linked to impairments in approximation ability specifically. Our findings support theoretical claims linking IPS to magnitude representation, but do not provide evidence that IPS critically underpins performance across all numeracy tasks. Instead, our findings are more compatible with models of dissociable circuits of numerical processing within the parietal lobe.

著名的计算理论将顶内沟（IPS）与支撑基本数学能力的数量近似表征联系起来。本综述的目的是通过对顶叶损伤患者进行以运算能力为重点的单个病例研究，并检验运算能力损伤与顶叶损伤部位之间的因果关系，从而从微积分学的角度更好地理解数学认知的神经基础。一项系统性文献综述确定了 27 个左顶叶病变的单一病例研究，并对四个计算领域的任务进行了分类：近似、计算、顺序/心算和转码。我们通过在推断的质量中心画一个球形来比较已发表的病变图像，并根据与左顶叶重叠情况和原始解剖描述将每个病例归入一个解剖学组（IPS 或其他顶叶损伤）。我们进行了费雪精确检验，以比较两组患者在每个算术领域的行为表现。作为一项探索性的后续研究，我们使用激活似然估计法（ALE）来确定顶叶皮层中与各领域障碍优先相关的损伤部位。我们发现，在 IPS 组中，接近障碍的发生率明显更高（P =.003）。探索性 ALE 分析显示，只有逼近障碍的病例与 IPS 有明显重叠，而其他领域的障碍则分布在顶叶的不同区域。根据这些病例所显示的损伤模式，我们得出结论，左侧 IPS 的损伤与近似能力的损伤特别相关。我们的研究结果支持将 IPS 与幅度表征联系起来的理论主张，但并没有提供证据证明 IPS 对所有算术任务的表现都起着关键作用。相反，我们的研究结果更符合顶叶内可分离的数字处理回路模型。

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引用次数: 0

Standardized extract of Ginkgo biloba induced memory consolidation in female mice with hypofunction of vesicular acetylcholine transporter

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-30 DOI: 10.1016/j.bbr.2025.115455

Beatriz G. Muratori , Irina Emanuela T. da Veiga , Gleiciene N. Medeiros , Sofia M.S. E. Silva , Andressa G. Soliani , Carla Máximo Prado , Suzete M. Cerutti

Basal forebrain cholinergic neurons are pivotal for cholinergic signaling in the neocortex and hippocampal formation, crucially implicated in neurodegenerative diseases like late-onset Alzheimer's disease (LOAD), recognition memory impairments, and decision-making. The acetylcholine transporter (VAChT) is essential for loading acetylcholine into synaptic vesicles. Building on our previous findings showing that Ginkgo biloba extract (EGb) preserves recognition memory, we hypothesized EGb would enhance memory in female mice with varying VAChT reductions. We also explored whether reduced cholinergic signaling induces anxiety-like behavior and whether EGb could alleviate such symptoms. Three-month-old female mice with severe VAChT reduction (knockdown homozygotes; VAChT KD^HOM), moderate reduction (heterozygotes; VAChT KD^HET), and wild-type (WT) mice received the vehicle, 5 mg/kg Donepezil, or EGb at doses of 250, 500, and 1000 mg/kg for 30 days. Memory assessments included aversive tasks like discriminative avoidance memory and non-aversive tasks like object recognition and location memory. We assessed VAChT protein expression in the hippocampal formation (HF) using Western blotting and quantified VAChT-immunopositive cells (IR⁺) in specific HF subfields (dCA1, dCA3, dDG) using immunohistochemistry. Chronic EGb treatment significantly improved long-term memory in female VAChT KD^HOM mice in object recognition and locations memories in a dose-dependent manner, unlike Donepezil. Enhanced memory was correlated with an increase in VAChT-IR⁺ cells in the dCA1 of VAChT KD^HOM mice. Additionally, EGb reduced VAChT-IR⁺ cells in the dDG of VAChT KD^HET mice, which was associated with decreased anxiety-like behavior. These findings suggest that EGb effectively mitigates deficits caused by cholinergic deficiency in hippocampal-dependent memory consolidation, thereby improving our understanding of its role in modulating long-term memory and hippocampal plasticity.

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引用次数: 0

Update on autoimmune dementia and its precursors

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-01-29 DOI: 10.1016/j.bbr.2025.115460

Niels Hansen

Autoimmune dementia is a new disease entity increasingly coming into focus, and novel neural antibodies associated with dementia and its precursors have been described. However, the significance of these novel and emerging autoantibodies in conjunction with cognitive disorders is unclear. Antibodies such as Leucin-Rich, Glioma Inactivated 1 (LGI1) and N-Methyl-D-Aspartate Receptor (NMDAR) are already known to be pathogenic by triggering anomalies in synaptic plasticity and learning processes in animal models after having been transferred from humans to animals. In this review we describe various pathogenic mechanisms of antibodies such as complement dependent cytotoxicity, the internalization of membrane receptors, antagonistic effects, and alterations in vesicle endocytosis at the synaptic level. We also discuss established autoantibodies such as membrane-surface and intracellular antibodies in connection with cognitive disorders, as well as autoantibodies associated with neurodegenerative dementia, and autoimmune encephalitis with primary dementia syndrome. Test methods and the response to immunotherapy are also briefly explained. This overview provides a differentiated presentation of a heterogeneous dementia entity with its precursors, which requires more research to develop a differentiated treatment guideline.

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引用次数: 0