Pub Date : 2026-01-06DOI: 10.3390/biomimetics11010042
Martin Becker, Alexander E Kovalev, Thies H Büscher, Stanislav N Gorb
Most insects secrete special fluids from their tarsal pads which are essential for the function of their attachment systems. Previous studies investigated several physical and chemical characteristics of this pad fluid in different insect species. However, there is not much known about the mechanical properties of fluid from smooth adhesive pads. In this study, we used the stress-relaxation nanoindentation method to examine the viscoelastic properties of pad fluid from Sungaya aeta. Force-displacement and stress-relaxation curves on single fluid droplets were recorded with an atomic force microscope (AFM) and analyzed using Johnson-Kendall-Roberts (JKR) and generalized Maxwell models for determination of effective elastic modulus (E), work of adhesion (Δγ) and dynamic viscosity (η). In addition, we used white light interferometry (WLI) to measure the maximal height of freshly acquired droplets. Our results revealed three different categories of droplets, which we named "almost inviscid", "viscous" and "rigid". They are presumably determined at the moment of secretion and retain their characteristics even for several days. The observed mechanical properties suggest a non-uniform composition of different droplets. These findings provide a basis for advancing our understanding about the requirements for adaptive adhesion-mediating fluids and, hence, aid in advancing technical solutions for soft or liquid temporal adhesives and gripping devices.
{"title":"Mechanical Characterization of Stick Insect Tarsal Attachment Fluid Using Atomic Force Microscopy (AFM).","authors":"Martin Becker, Alexander E Kovalev, Thies H Büscher, Stanislav N Gorb","doi":"10.3390/biomimetics11010042","DOIUrl":"10.3390/biomimetics11010042","url":null,"abstract":"<p><p>Most insects secrete special fluids from their tarsal pads which are essential for the function of their attachment systems. Previous studies investigated several physical and chemical characteristics of this pad fluid in different insect species. However, there is not much known about the mechanical properties of fluid from smooth adhesive pads. In this study, we used the stress-relaxation nanoindentation method to examine the viscoelastic properties of pad fluid from <i>Sungaya aeta</i>. Force-displacement and stress-relaxation curves on single fluid droplets were recorded with an atomic force microscope (AFM) and analyzed using Johnson-Kendall-Roberts (JKR) and generalized Maxwell models for determination of effective elastic modulus (E), work of adhesion (Δγ) and dynamic viscosity (η). In addition, we used white light interferometry (WLI) to measure the maximal height of freshly acquired droplets. Our results revealed three different categories of droplets, which we named \"almost inviscid\", \"viscous\" and \"rigid\". They are presumably determined at the moment of secretion and retain their characteristics even for several days. The observed mechanical properties suggest a non-uniform composition of different droplets. These findings provide a basis for advancing our understanding about the requirements for adaptive adhesion-mediating fluids and, hence, aid in advancing technical solutions for soft or liquid temporal adhesives and gripping devices.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.3390/biomimetics11010043
Yong Xu, Ning Xue, Yi Zhang
This paper presents the Circle-Mapping Transition and Weighted Red-Billed Blue Magpie Optimizer (CTWRBMO), designed to address significant challenges in 3D path planning for drones. Although the original Red-Billed Blue Magpie Optimizer (RBMO) algorithm features a simple structure, few parameters, and strong local search capability, making it well-suited for UAV path optimization, it suffers from insufficient population diversity, limited global search ability, and a tendency to fall into local optima in complex high-dimensional scenarios. To overcome these limitations, four enhancement strategies are introduced. Firstly, the Circle chaotic mapping strategy leverages the randomness and ergodicity of chaotic sequences to generate an initial population that is uniformly distributed. This enhancement improves population diversity from the beginning and provides a solid foundation for global optimization. Secondly, the ε parameter is dynamically adjusted to prioritize local refinement during the early stages of optimization. This adjustment enables rapid convergence toward potentially optimal areas. This parameter increases to enhance global search capabilities as the algorithm progresses, thereby broadening the optimization space and achieving a dynamic equilibrium. Additionally, a nonlinear dynamic weighting factor (wd) is incorporated into the position update formula. The algorithm's ability to escape local optima is significantly improved by dynamically altering the weight ratio between historical optimal positions and the current position. Furthermore, an elite perturbation mechanism based on individual neighborhoods is implemented to generate candidate solutions using local information. This mechanism enhances the algorithm's local exploration capabilities and improves the stability of preserving optimal solutions, supported by a greedy criterion for optimal retention. Experimental results show that the CTWRBMO algorithm significantly outperforms comparison algorithms in terms of optimization accuracy and convergence speed, demonstrating exceptional global optimization capabilities. Additional applications in UAV 3D path planning simulations evaluated paths based on length, threat avoidance efficiency, and smoothness. The results indicate that paths planned using CTWRBMO are shorter, safer, and smoother compared to those generated by the Harrier Hawks Optimization (HHO), African Vulture Optimization Algorithm (AVOA), Artificial Bee Colony (ABC) Algorithm, and the traditional Magpie Algorithm, effectively meeting practical engineering requirements for UAV 3D path planning.
本文介绍了圆形映射过渡和加权红嘴蓝喜鹊优化器(CTWRBMO),旨在解决无人机3D路径规划中的重大挑战。原有的RBMO (red - bill Blue Magpie Optimizer)算法结构简单、参数少、局部搜索能力强,非常适合无人机路径优化,但存在种群多样性不足、全局搜索能力有限、在复杂高维场景下容易陷入局部最优的问题。为了克服这些限制,介绍了四种增强策略。首先,圆混沌映射策略利用混沌序列的随机性和遍历性生成均匀分布的初始种群。这种增强从一开始就提高了种群多样性,为全局优化提供了坚实的基础。其次,动态调整ε参数,在优化的早期阶段优先考虑局部优化。这种调整使快速收敛到潜在的最优区域。该参数随着算法的进展而增大,以增强全局搜索能力,从而扩大优化空间,达到动态平衡。此外,在位置更新公式中引入了非线性动态加权因子wd。通过动态改变历史最优位置与当前位置的权重比,显著提高了算法逃避局部最优的能力。此外,采用基于个体邻域的精英摄动机制,利用局部信息生成候选解。该机制增强了算法的局部搜索能力,提高了保持最优解的稳定性,并得到了最优保留的贪婪准则的支持。实验结果表明,CTWRBMO算法在优化精度和收敛速度方面明显优于比较算法,具有出色的全局优化能力。在无人机3D路径规划仿真中的其他应用基于长度、威胁规避效率和平滑度评估路径。结果表明,与鹞鹰优化算法(HHO)、非洲秃鹫优化算法(AVOA)、人工蜂群算法(ABC)和传统的鹊算法相比,CTWRBMO规划的路径更短、更安全、更平滑,有效地满足了无人机三维路径规划的实际工程要求。
{"title":"An Improved Red-Billed Blue Magpie Optimization Algorithm for 3D UAV Path Planning in Complex Terrain.","authors":"Yong Xu, Ning Xue, Yi Zhang","doi":"10.3390/biomimetics11010043","DOIUrl":"10.3390/biomimetics11010043","url":null,"abstract":"<p><p>This paper presents the Circle-Mapping Transition and Weighted Red-Billed Blue Magpie Optimizer (CTWRBMO), designed to address significant challenges in 3D path planning for drones. Although the original Red-Billed Blue Magpie Optimizer (RBMO) algorithm features a simple structure, few parameters, and strong local search capability, making it well-suited for UAV path optimization, it suffers from insufficient population diversity, limited global search ability, and a tendency to fall into local optima in complex high-dimensional scenarios. To overcome these limitations, four enhancement strategies are introduced. Firstly, the Circle chaotic mapping strategy leverages the randomness and ergodicity of chaotic sequences to generate an initial population that is uniformly distributed. This enhancement improves population diversity from the beginning and provides a solid foundation for global optimization. Secondly, the ε parameter is dynamically adjusted to prioritize local refinement during the early stages of optimization. This adjustment enables rapid convergence toward potentially optimal areas. This parameter increases to enhance global search capabilities as the algorithm progresses, thereby broadening the optimization space and achieving a dynamic equilibrium. Additionally, a nonlinear dynamic weighting factor (wd) is incorporated into the position update formula. The algorithm's ability to escape local optima is significantly improved by dynamically altering the weight ratio between historical optimal positions and the current position. Furthermore, an elite perturbation mechanism based on individual neighborhoods is implemented to generate candidate solutions using local information. This mechanism enhances the algorithm's local exploration capabilities and improves the stability of preserving optimal solutions, supported by a greedy criterion for optimal retention. Experimental results show that the CTWRBMO algorithm significantly outperforms comparison algorithms in terms of optimization accuracy and convergence speed, demonstrating exceptional global optimization capabilities. Additional applications in UAV 3D path planning simulations evaluated paths based on length, threat avoidance efficiency, and smoothness. The results indicate that paths planned using CTWRBMO are shorter, safer, and smoother compared to those generated by the Harrier Hawks Optimization (HHO), African Vulture Optimization Algorithm (AVOA), Artificial Bee Colony (ABC) Algorithm, and the traditional Magpie Algorithm, effectively meeting practical engineering requirements for UAV 3D path planning.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12839416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enhancing the explosive power output of the knee joints is critical for improving the agility and obstacle crossing of humanoid robots. However, a mismatch between the knee-to-CoM transmission ratio and jumping demands, together with power-loss-induced motor performance degradation at high speeds, shortens the high-power operating window and limits jump performance. To address this, this paper introduces a variable-reduction-ratio knee-joint paradigm in which the reduction ratio is coupled to the joint angle and decreases during extension. Analysis of motor output and knee kinematics motivates coupling the reduction ratio to the joint angle. A high initial ratio increases the takeoff torque, and a gradual decrease limits motor speed and power losses, extending the high-power window. A linear-actuator-driven guide-rod mechanism realizes this strategy, and parameter optimization guided by explosive jump control is employed to select the design parameters. Experimental validation demonstrates a high jump of 0.63 m on a single-joint platform (a theoretical improvement of 31.9% over the optimal fixed-ratio baseline under the tested conditions). Integrated into a humanoid robot, the proposed design enables a 1.1 m long jump, a 0.5 m high jump, and a 0.5 m box jump.
{"title":"Explosive Output to Enhance Jumping Ability: A Variable Reduction Ratio Design Paradigm for Humanoid Robot Knee Joint.","authors":"Xiaoshuai Ma, Qingqing Li, Haochen Xu, Xuechao Chen, Junyao Gao, Fei Meng","doi":"10.3390/biomimetics11010045","DOIUrl":"10.3390/biomimetics11010045","url":null,"abstract":"<p><p>Enhancing the explosive power output of the knee joints is critical for improving the agility and obstacle crossing of humanoid robots. However, a mismatch between the knee-to-CoM transmission ratio and jumping demands, together with power-loss-induced motor performance degradation at high speeds, shortens the high-power operating window and limits jump performance. To address this, this paper introduces a variable-reduction-ratio knee-joint paradigm in which the reduction ratio is coupled to the joint angle and decreases during extension. Analysis of motor output and knee kinematics motivates coupling the reduction ratio to the joint angle. A high initial ratio increases the takeoff torque, and a gradual decrease limits motor speed and power losses, extending the high-power window. A linear-actuator-driven guide-rod mechanism realizes this strategy, and parameter optimization guided by explosive jump control is employed to select the design parameters. Experimental validation demonstrates a high jump of 0.63 m on a single-joint platform (a theoretical improvement of 31.9% over the optimal fixed-ratio baseline under the tested conditions). Integrated into a humanoid robot, the proposed design enables a 1.1 m long jump, a 0.5 m high jump, and a 0.5 m box jump.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12839399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study presents a magnetically actuated soft robot inspired by the peristaltic locomotion of flatworms, designed to replicate the biological locomotion of worms to achieve robust maneuverability. Fabricated entirely from photocurable soft resin, the robot features a flexible elastomeric body and two webbed fins with embedded soft magnets. By applying a vertically oscillating magnetic field, the robot achieves forward crawling through the coordinated bending and lifting of fins, converting oscillating magnetic fields into continuous undulatory motion that mimics the gait of flatworms. The experimental results demonstrate that the system maintains consistent bidirectional velocities in the range of 4-7 mm/s on flat surfaces. Beyond linear locomotion, the robot demonstrates effective terrain adaptability, navigating complex topographies, including curved obstacles up to 16 times its body thickness, by autonomously adopting a high-lifting kinematic strategy to overcome gravitational resistance. Furthermore, load-carrying tests reveal that the robot can transport a 6 g payload without velocity degradation. These findings underscore the robot's efficacy in overcoming mobility constraints, highlighting promising applications in fields requiring non-invasive intervention, such as biomedical capsule endoscopy and industrial pipeline inspection.
{"title":"Navigation and Load Adaptability of a Flatworm-Inspired Soft Robot Actuated by Staggered Magnetization Structure.","authors":"Zixu Wang, Miaozhang Shen, Chunying Li, Pengcheng Li, Anran Zheng, Shuxiang Guo","doi":"10.3390/biomimetics11010041","DOIUrl":"10.3390/biomimetics11010041","url":null,"abstract":"<p><p>This study presents a magnetically actuated soft robot inspired by the peristaltic locomotion of flatworms, designed to replicate the biological locomotion of worms to achieve robust maneuverability. Fabricated entirely from photocurable soft resin, the robot features a flexible elastomeric body and two webbed fins with embedded soft magnets. By applying a vertically oscillating magnetic field, the robot achieves forward crawling through the coordinated bending and lifting of fins, converting oscillating magnetic fields into continuous undulatory motion that mimics the gait of flatworms. The experimental results demonstrate that the system maintains consistent bidirectional velocities in the range of 4-7 mm/s on flat surfaces. Beyond linear locomotion, the robot demonstrates effective terrain adaptability, navigating complex topographies, including curved obstacles up to 16 times its body thickness, by autonomously adopting a high-lifting kinematic strategy to overcome gravitational resistance. Furthermore, load-carrying tests reveal that the robot can transport a 6 g payload without velocity degradation. These findings underscore the robot's efficacy in overcoming mobility constraints, highlighting promising applications in fields requiring non-invasive intervention, such as biomedical capsule endoscopy and industrial pipeline inspection.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.3390/biomimetics11010040
Jie Xue, Zhiyuan Liang, Haiming Mou, Qingdu Li, Jianwei Zhang
The presence of sensor noise, missing states and inadequate future prediction capabilities imposes significant limitations on the locomotion performance of bipedal robots operating in unstructured terrain. Conventional methods generally depend on long-term history observations to reconstruct single-frame privileged information. However, these methods fail to acknowledge the pivotal function of short-term history in rapid state responses and the significance of future state prediction in anticipating potential risks. The proposed framework is a Long-Short World Model (LSWM), which integrates state reconstruction and future state prediction to enhance the locomotion capabilities of bipedal robots in complex environments. The LSWM framework comprises two modules: a state reconstruction module (SRM) and a future state prediction module (SPM). The state reconstruction module employs long-term history observations to reconstruct privileged information in the current short-term history, thereby effectively improving the system's robustness to sensor noise and enhancing state observability. The future state prediction module enhances the robot's adaptability to complex environments and unpredictable scenarios by predicting the robot's future short-term privileged information. We conducted extensive comparative experiments in simulation as well as in a variety of real-world indoor and outdoor environments. In the indoor stair-climbing task, LSWM achieved a 94% success rate, outperforming the current state-of-the-art baseline methods by at least 34%, thereby demonstrating its substantial performance advantages in complex and dynamic environments.
{"title":"LSWM: A Long-Short History World Model for Bipedal Locomotion via Reinforcement Learning.","authors":"Jie Xue, Zhiyuan Liang, Haiming Mou, Qingdu Li, Jianwei Zhang","doi":"10.3390/biomimetics11010040","DOIUrl":"10.3390/biomimetics11010040","url":null,"abstract":"<p><p>The presence of sensor noise, missing states and inadequate future prediction capabilities imposes significant limitations on the locomotion performance of bipedal robots operating in unstructured terrain. Conventional methods generally depend on long-term history observations to reconstruct single-frame privileged information. However, these methods fail to acknowledge the pivotal function of short-term history in rapid state responses and the significance of future state prediction in anticipating potential risks. The proposed framework is a Long-Short World Model (LSWM), which integrates state reconstruction and future state prediction to enhance the locomotion capabilities of bipedal robots in complex environments. The LSWM framework comprises two modules: a state reconstruction module (SRM) and a future state prediction module (SPM). The state reconstruction module employs long-term history observations to reconstruct privileged information in the current short-term history, thereby effectively improving the system's robustness to sensor noise and enhancing state observability. The future state prediction module enhances the robot's adaptability to complex environments and unpredictable scenarios by predicting the robot's future short-term privileged information. We conducted extensive comparative experiments in simulation as well as in a variety of real-world indoor and outdoor environments. In the indoor stair-climbing task, LSWM achieved a 94% success rate, outperforming the current state-of-the-art baseline methods by at least 34%, thereby demonstrating its substantial performance advantages in complex and dynamic environments.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.3390/biomimetics11010037
Guolin Zhai, Sai Li
Feature selection and continuous optimization are fundamental yet challenging tasks in machine learning and engineering design. To address premature convergence and insufficient population diversity in Student Psychology-Based Optimization (SPBO), this paper proposes a Multi-Strategy-Enhanced Student Psychology-Based Optimizer (MESPBO). The proposed method incorporates three complementary strategies: (i) a hybrid heuristic initialization scheme based on Latin Hypercube Sampling and Gaussian perturbation; (ii) an adaptive dual-learning position update mechanism to dynamically balance exploration and exploitation; (iii) a hybrid opposition-based reflective boundary control strategy to enhance search stability. Extensive experiments on the CEC2017 benchmark suite with 10, 30, and 50 dimensions demonstrate that MESPBO consistently outperforms 11 state-of-the-art metaheuristic algorithms. Specifically, MESPBO achieves the best Friedman mean ranks of 2.00, 1.67, and 1.67 under 10D, 30D, and 50D settings, respectively, indicating superior convergence accuracy, robustness, and scalability. In real-world feature selection tasks conducted on 10 benchmark datasets, MESPBO achieves the highest average classification accuracy on 9 datasets, reaching 100% accuracy on several datasets, while maintaining competitive performance on the remaining one. Moreover, MESPBO selects the smallest feature subsets on 7 datasets, typically retaining only 2-4 features without sacrificing classification accuracy. Compared with the original SPBO, MESPBO further reduces the fitness values on 7 out of 10 datasets, achieving an average improvement of approximately 10%. These results verify that MESPBO provides an effective trade-off between optimization accuracy and feature compactness, demonstrating strong adaptability and generalization capability for both global optimization and feature selection problems.
{"title":"MESPBO: Multi-Strategy-Enhanced Student Psychology-Based Optimization Algorithm for Global Optimization Problems and Feature Selection Problems.","authors":"Guolin Zhai, Sai Li","doi":"10.3390/biomimetics11010037","DOIUrl":"10.3390/biomimetics11010037","url":null,"abstract":"<p><p>Feature selection and continuous optimization are fundamental yet challenging tasks in machine learning and engineering design. To address premature convergence and insufficient population diversity in Student Psychology-Based Optimization (SPBO), this paper proposes a Multi-Strategy-Enhanced Student Psychology-Based Optimizer (MESPBO). The proposed method incorporates three complementary strategies: (i) a hybrid heuristic initialization scheme based on Latin Hypercube Sampling and Gaussian perturbation; (ii) an adaptive dual-learning position update mechanism to dynamically balance exploration and exploitation; (iii) a hybrid opposition-based reflective boundary control strategy to enhance search stability. Extensive experiments on the CEC2017 benchmark suite with 10, 30, and 50 dimensions demonstrate that MESPBO consistently outperforms 11 state-of-the-art metaheuristic algorithms. Specifically, MESPBO achieves the best Friedman mean ranks of 2.00, 1.67, and 1.67 under 10D, 30D, and 50D settings, respectively, indicating superior convergence accuracy, robustness, and scalability. In real-world feature selection tasks conducted on 10 benchmark datasets, MESPBO achieves the highest average classification accuracy on 9 datasets, reaching 100% accuracy on several datasets, while maintaining competitive performance on the remaining one. Moreover, MESPBO selects the smallest feature subsets on 7 datasets, typically retaining only 2-4 features without sacrificing classification accuracy. Compared with the original SPBO, MESPBO further reduces the fitness values on 7 out of 10 datasets, achieving an average improvement of approximately 10%. These results verify that MESPBO provides an effective trade-off between optimization accuracy and feature compactness, demonstrating strong adaptability and generalization capability for both global optimization and feature selection problems.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12839440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.3390/biomimetics11010039
Ridwan Boya Marqas, Zsuzsa Simó, Abdulazeez Mousa, Fatih Özyurt, Laszlo Barna Iantovics
Drug-drug interactions (DDIs) can cause adverse reactions or reduce the efficiency of a drug. Using computers to predict DDIs is now critical in pharmacology, as this reduces risks, improves drug outcomes and lowers healthcare costs. Clinical trials are slow, expensive, and require a lot of effort. The use of artificial intelligence (AI), primarily in the form of machine learning (ML) and its subfield deep learning (DL), has made DDI prediction more accurate and efficient when handling large datasets from biological, chemical, and clinical domains. Many ML and DL approaches are bio-inspired, taking inspiration from natural systems, and are considered part of the broader class of biomimetic methods. This review provides a comprehensive overview of AI-based methods currently used for DDI prediction. These include classical ML algorithms, such as logistic regression (LR) and support vector machines (SVMs); advanced DL models, such as deep neural networks (DNNs) and long short-term memory networks (LSTMs); graph-based models, such as graph convolutional networks (GCNs) and graph attention networks (GATs); and ensemble techniques. The use of knowledge graphs and transformers to capture relations and meaningful data about drugs is also investigated. Additionally, emerging biomimetic approaches offer promising directions for the future in designing AI models that can emulate the complexity of pharmacological interactions. These upgrades include using genetic algorithms with LR and SVM, neuroevaluation (brain-inspired model optimization) to improve DNN and LSTM architectures, ant-colony-inspired path exploration with GCN and GAT, and immune-inspired attention mechanisms in transformer models. This manuscript reviews the typical types of data employed in DDI (pDDI) prediction studies and the evaluation methods employed, discussing the pros and cons of each. There are useful approaches outlined that reveal important points that require further research and suggest ways to improve the accuracy, usability, and understanding of DDI prediction models.
{"title":"Advancing Drug-Drug Interaction Prediction with Biomimetic Improvements: Leveraging the Latest Artificial Intelligence Techniques to Guide Researchers in the Field.","authors":"Ridwan Boya Marqas, Zsuzsa Simó, Abdulazeez Mousa, Fatih Özyurt, Laszlo Barna Iantovics","doi":"10.3390/biomimetics11010039","DOIUrl":"10.3390/biomimetics11010039","url":null,"abstract":"<p><p>Drug-drug interactions (DDIs) can cause adverse reactions or reduce the efficiency of a drug. Using computers to predict DDIs is now critical in pharmacology, as this reduces risks, improves drug outcomes and lowers healthcare costs. Clinical trials are slow, expensive, and require a lot of effort. The use of artificial intelligence (AI), primarily in the form of machine learning (ML) and its subfield deep learning (DL), has made DDI prediction more accurate and efficient when handling large datasets from biological, chemical, and clinical domains. Many ML and DL approaches are bio-inspired, taking inspiration from natural systems, and are considered part of the broader class of biomimetic methods. This review provides a comprehensive overview of AI-based methods currently used for DDI prediction. These include classical ML algorithms, such as logistic regression (LR) and support vector machines (SVMs); advanced DL models, such as deep neural networks (DNNs) and long short-term memory networks (LSTMs); graph-based models, such as graph convolutional networks (GCNs) and graph attention networks (GATs); and ensemble techniques. The use of knowledge graphs and transformers to capture relations and meaningful data about drugs is also investigated. Additionally, emerging biomimetic approaches offer promising directions for the future in designing AI models that can emulate the complexity of pharmacological interactions. These upgrades include using genetic algorithms with LR and SVM, neuroevaluation (brain-inspired model optimization) to improve DNN and LSTM architectures, ant-colony-inspired path exploration with GCN and GAT, and immune-inspired attention mechanisms in transformer models. This manuscript reviews the typical types of data employed in DDI (pDDI) prediction studies and the evaluation methods employed, discussing the pros and cons of each. There are useful approaches outlined that reveal important points that require further research and suggest ways to improve the accuracy, usability, and understanding of DDI prediction models.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12839390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.3390/biomimetics11010038
Jiutian Xia, Jialong Cao, Tao Ren, Yonghua Chen, Ye Chen, Yunquan Li
Pneumatic artificial muscles (PAMs) are inherently compliant and relatively safe. They are widely used in applications where human beings and robots interact closely, such as service robots or medical robots. However, PAMs are constrained by bulky pumps and valve control systems, limiting their mobility, portability, and practical applications. In this research, a novel type of artificial muscle, namely Twisting Tube Artificial Muscle (TTAM), is presented. In a TTAM design, fluid (pressurized air in this research) is contained inside an elastic tube (constrained by a braiding). By twisting the tube from one end, the fluid inside the twisted part will be extruded to the untwisted part, resulting in a pressure increase inside the untwisted part. Both the twisted and untwisted parts will thus contract. Modeling and experimental characterization of the TTAM are conducted. In an experimental test at 100 kPa initial air pressure, after a 6π twisting angle, the internal pressure of a prototype TTAM is increased to 219 kPa, and the largest contraction force of the TTAM was up to 200 N. A novel antagonistic robotic joint actuated by two TTAMs is developed as a sample application.
{"title":"Twisting Tube Artificial Muscle (TTAM) and Its Application in Agonist and Antagonist Drive.","authors":"Jiutian Xia, Jialong Cao, Tao Ren, Yonghua Chen, Ye Chen, Yunquan Li","doi":"10.3390/biomimetics11010038","DOIUrl":"10.3390/biomimetics11010038","url":null,"abstract":"<p><p>Pneumatic artificial muscles (PAMs) are inherently compliant and relatively safe. They are widely used in applications where human beings and robots interact closely, such as service robots or medical robots. However, PAMs are constrained by bulky pumps and valve control systems, limiting their mobility, portability, and practical applications. In this research, a novel type of artificial muscle, namely Twisting Tube Artificial Muscle (TTAM), is presented. In a TTAM design, fluid (pressurized air in this research) is contained inside an elastic tube (constrained by a braiding). By twisting the tube from one end, the fluid inside the twisted part will be extruded to the untwisted part, resulting in a pressure increase inside the untwisted part. Both the twisted and untwisted parts will thus contract. Modeling and experimental characterization of the TTAM are conducted. In an experimental test at 100 kPa initial air pressure, after a 6π twisting angle, the internal pressure of a prototype TTAM is increased to 219 kPa, and the largest contraction force of the TTAM was up to 200 N. A novel antagonistic robotic joint actuated by two TTAMs is developed as a sample application.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dexterous hands are the core end-effectors of humanoid robots, and their design is a key research focus in this field. With multiple independent finger units, the units' dexterity directly determines the hand's operational performance, yet achieving three-degree-of-freedom (3-DOF) anthropomorphic motion remains a key design challenge. To address this, this paper proposes a hybrid-driven index finger unit: combining linkage and tendon-cable drive advantages to realize 3-DOF anthropomorphic motion, and adopting independent drive/transmission modules to simplify manufacturing and boost parameter optimization flexibility. Validated via motion dynamics, DOF, and operational force assessments, this design offers key unit tech for dexterous hand development and serves as a reference for optimizing multi-DOF anthropomorphic finger designs.
{"title":"Finger Unit Design for Hybrid-Driven Dexterous Hands.","authors":"Chong Deng, Wenhao Lu, Yizhou Qian, Yongjian Liu, Meng Ning, Ziheng Zhan","doi":"10.3390/biomimetics11010035","DOIUrl":"10.3390/biomimetics11010035","url":null,"abstract":"<p><p>Dexterous hands are the core end-effectors of humanoid robots, and their design is a key research focus in this field. With multiple independent finger units, the units' dexterity directly determines the hand's operational performance, yet achieving three-degree-of-freedom (3-DOF) anthropomorphic motion remains a key design challenge. To address this, this paper proposes a hybrid-driven index finger unit: combining linkage and tendon-cable drive advantages to realize 3-DOF anthropomorphic motion, and adopting independent drive/transmission modules to simplify manufacturing and boost parameter optimization flexibility. Validated via motion dynamics, DOF, and operational force assessments, this design offers key unit tech for dexterous hand development and serves as a reference for optimizing multi-DOF anthropomorphic finger designs.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12839331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-04DOI: 10.3390/biomimetics11010036
Xin Tao, Li Bin
To improve the continuous chordwise bending performance of morphing wings, this study proposes a rigid-flexible coupled wing rib structure and its control strategy. Initially, the optimal rigid-flexible hybrid configuration was optimized via the mean camber line parameterization and genetic algorithm. For the flexible segment, topology optimization was conducted using the load path method, followed by subspace-based shape-size alternating optimization; bionic "longbow" curved beams and 'S'-shaped substructures were adopted to enhance deformability. Biomimetic pneumatic muscles were used as actuators, and a fuzzy-adjusted PI sliding mode controller was designed to address the issue that traditional PI sliding mode controllers cannot achieve precise control under non-optimal parameters or when there is a significant difference in deformation targets. Experimental results show that when the flexible rib deflects by 15°, the three-rib wing box achieves a 30° deflection, with stresses within the allowable limit of 7075Al-T6 (540 MPa) and a deformation error of only 7.6%. For the 15° downward bending control, the adjustment time is 6.06 s, the steady-state error is 0.19°, and the overshoot is 1.8%. This study verifies the feasibility of the proposed rigid-flexible coupled structure and fuzzy PI-SMC, providing a technical reference for morphing aircraft.
{"title":"Research on Design and Control Method of Flexible Wing Ribs with Chordwise Variable Camber.","authors":"Xin Tao, Li Bin","doi":"10.3390/biomimetics11010036","DOIUrl":"10.3390/biomimetics11010036","url":null,"abstract":"<p><p>To improve the continuous chordwise bending performance of morphing wings, this study proposes a rigid-flexible coupled wing rib structure and its control strategy. Initially, the optimal rigid-flexible hybrid configuration was optimized via the mean camber line parameterization and genetic algorithm. For the flexible segment, topology optimization was conducted using the load path method, followed by subspace-based shape-size alternating optimization; bionic \"longbow\" curved beams and 'S'-shaped substructures were adopted to enhance deformability. Biomimetic pneumatic muscles were used as actuators, and a fuzzy-adjusted PI sliding mode controller was designed to address the issue that traditional PI sliding mode controllers cannot achieve precise control under non-optimal parameters or when there is a significant difference in deformation targets. Experimental results show that when the flexible rib deflects by 15°, the three-rib wing box achieves a 30° deflection, with stresses within the allowable limit of 7075Al-T6 (540 MPa) and a deformation error of only 7.6%. For the 15° downward bending control, the adjustment time is 6.06 s, the steady-state error is 0.19°, and the overshoot is 1.8%. This study verifies the feasibility of the proposed rigid-flexible coupled structure and fuzzy PI-SMC, providing a technical reference for morphing aircraft.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}