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Multi-Strategy Improved Pelican Optimization Algorithm for Engineering Optimization Problems and 3D UAV Path Planning. 工程优化问题与三维无人机路径规划的多策略改进鹈鹕优化算法。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-15 DOI: 10.3390/biomimetics11010073
Ming Zhang, Maomao Luo, Huiming Kang

To address the path-planning challenge for unmanned aerial vehicles (UAVs) in complex environments, this study presents an improved pelican optimization algorithm enhanced with multiple strategies (MIPOA). The proposed method introduces four main improvements: (1) using chaotic mapping to spread the initial search points more evenly, thereby increasing population variety; (2) incorporating a random Lévy-flight strategy to improve the exploration of the search space; (3) integrating a differential evolution approach based on Cauchy mutation to strengthen individual diversity and overall optimization ability; and (4) adopting an adaptive disturbance factor to speed up convergence and fine-tune solutions. To evaluate MIPOA, comparative tests were carried out against classical and modern intelligent algorithms using the CEC2017 and CEC2022 benchmark sets, along with a custom UAV environmental model. Results show that MIPOA converges faster and achieves more accurate solutions than the original pelican optimization algorithm (POA). On CEC2017 in 30-, 50-, and 100-dimensional cases, MIPOA attained the best average ranks of 1.57, 2.37, and 2.90, respectively, and achieved the top results on 26, 21, and 19 test functions, outperforming both POA and other advanced algorithms. For CEC2022 (20 dimensions), MIPOA obtained the highest Friedman average rank of 1.42, demonstrating its effectiveness in complex UAV path-planning tasks. The method enables the generation of faster, shorter, safer, and collision-free flight paths for UAVs, underscoring the robustness and wide applicability of MIPOA in real-world UAV path-planning scenarios.

针对无人机在复杂环境下的路径规划问题,提出了一种改进的多策略鹈鹕优化算法。该方法主要有四个方面的改进:(1)利用混沌映射更均匀地分散初始搜索点,从而增加种群的多样性;(2)采用随机lcv -flight策略,提高搜索空间的探索能力;(3)整合基于柯西突变的差分进化方法,增强个体多样性和整体优化能力;(4)采用自适应扰动因子加速收敛和微调解。为了评估MIPOA,使用CEC2017和CEC2022基准集,以及定制的无人机环境模型,对经典和现代智能算法进行了比较测试。结果表明,与原有的鹈鹕优化算法(pelican optimization algorithm, POA)相比,该算法收敛速度更快,求解精度更高。在CEC2017上,在30维、50维和100维情况下,MIPOA分别获得了1.57、2.37和2.90的最佳平均排名,并在26、21和19个测试函数上取得了最佳成绩,超过了POA和其他先进算法。对于CEC2022(20维),MIPOA获得了最高的弗里德曼平均排名1.42,证明了其在复杂无人机路径规划任务中的有效性。该方法能够为无人机生成更快、更短、更安全、无碰撞的飞行路径,强调了MIPOA在实际无人机路径规划场景中的鲁棒性和广泛适用性。
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引用次数: 0
Multi-Strategy Fusion Improved Walrus Optimization Algorithm for Coverage Optimization in Wireless Sensor Networks. 基于多策略融合的改进海象优化算法的无线传感器网络覆盖优化。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-15 DOI: 10.3390/biomimetics11010072
Ling Li, Youyi Ding, Xiancun Zhou, Xuemei Zhu, Zongling Wu, Wei Peng, Jingya Zhang, Chaochuan Jia

The Walrus Optimization (WO) algorithm, a metaheuristic inspired by walrus behavior, is known for its competitive convergence speed and effectiveness in solving high-dimensional and practical engineering optimization problems. However, it suffers from a tendency to converge to local optima and exhibits instability during the iterative process. To overcome these limitations, this study proposes an improved WO (IMWO) algorithm based on the integration of Differential Evolution/best/1 (DE/best/1) mutation, Logistics-Sine-Cosine (LSC) Mapping, and the Beta Opposition-Based Learning (Beta-OBL) strategy. These strategies work synergistically to enhance the algorithm's global exploration capability, improve its search stability, and accelerate convergence with higher precision. The performance of the IMWO algorithm was comprehensively evaluated using the CEC2017 and CEC2022 benchmark test suites, where it was compared against the original WO algorithm and six other state-of-the-art metaheuristics. Experimental data revealed that the IMWO algorithm achieved average fitness rankings of 1.66 and 1.33 in the two test suites, ranking first among all compared algorithms. The WSN coverage optimization problem aims to maximize the monitored area while reducing perception blind spots under limited node resources and energy constraints, which is a typical complex optimization problem with multiple constraints. In a practical application addressing the coverage optimization problem in Wireless Sensor Networks (WSNs), the IMWO algorithm attained average coverage rates of 95.86% and 96.48% in two sets of coverage experiments, outperforming both the original WO and other compared algorithms. These results confirm the practical utility and robustness of the IMWO algorithm in solving complex real-world engineering problems.

海象优化算法(WO)是一种受海象行为启发的元启发式算法,在解决高维和实际工程优化问题方面具有较快的收敛速度和有效性。然而,它在迭代过程中有收敛于局部最优的倾向,并表现出不稳定性。为了克服这些局限性,本研究提出了一种基于差分进化/最佳/1 (DE/best/1)突变、logistic -正弦-余弦(LSC)映射和基于对立的学习(Beta- obl)策略的改进WO (IMWO)算法。这些策略协同工作,增强了算法的全局搜索能力,提高了算法的搜索稳定性,加快了算法的收敛速度,提高了算法的精度。使用CEC2017和CEC2022基准测试套件对IMWO算法的性能进行了全面评估,并将其与原始WO算法和其他六种最先进的元启发式算法进行了比较。实验数据显示,IMWO算法在两个测试套件中的平均适应度排名分别为1.66和1.33,在所有被比较算法中排名第一。无线传感器网络覆盖优化问题的目标是在有限节点资源和能量约束下实现监测面积最大化,同时减少感知盲点,是典型的多约束复杂优化问题。在解决无线传感器网络(WSNs)覆盖优化问题的实际应用中,IMWO算法在两组覆盖实验中获得了95.86%和96.48%的平均覆盖率,优于原始WO算法和其他比较算法。这些结果证实了IMWO算法在解决复杂的实际工程问题中的实用性和鲁棒性。
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引用次数: 0
Enhanced Fracture Energy and Toughness of UV-Curable Resin Using Flax Fiber Composite Laminates. 亚麻纤维复合层压板增强紫外线固化树脂的断裂能和韧性。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-15 DOI: 10.3390/biomimetics11010071
Mingwen Ou, Huan Li, Dequan Tan, Yizhen Peng, Hao Zhong, Linmei Wu, Wubin Shan

Ultraviolet (UV) curable resins are widely used in photopolymerization-based 3D printing due to their rapid curing and compatibility with high-resolution processes. However, their brittleness and limited mechanical performance restrict their applicability, particularly in impact-resistant high-performance 3D-printed structures. Inspired by the mantis shrimp's exceptional energy absorption and impact resistance, attributed to its helicoidal fiber architecture, we developed a Bouligand flax fiber-reinforced composite laminate. By constructing biomimetic helicoidal composites based on Bouligand arrangements, the mechanical performance of flax fiber-reinforced UV-curable resin was systematically investigated. The influence of flax fiber orientation was assessed using mechanical testing combined with the digital image correlation (DIC) method. The results demonstrate that a 45° interlayer angle of flax fiber significantly enhanced the fracture energy of the resin from 1.67 KJ/m2 to 15.41 KJ/m2, an increase of ~823%. Moreover, the flax fiber-reinforced helicoidal structure markedly improved the ultimate tensile strength of the resin, with the 90° interlayer angle of flax fiber exhibiting the greatest enhancement, increasing from 5.32 MPa to 19.45 MPa.

紫外光固化树脂由于其快速固化和与高分辨率工艺的兼容性,被广泛用于基于光聚合的3D打印。然而,它们的脆性和有限的机械性能限制了它们的适用性,特别是在抗冲击的高性能3d打印结构中。受螳螂虾独特的能量吸收和抗冲击能力(归功于其螺旋纤维结构)的启发,我们开发了Bouligand亚麻纤维增强复合材料层压板。通过构建基于布利甘排列的仿生螺旋复合材料,系统地研究了亚麻纤维增强光固化树脂的力学性能。采用力学试验结合数字图像相关(DIC)方法,对亚麻纤维取向的影响进行了评价。结果表明:当亚麻纤维层间角为45°时,树脂的断裂能由1.67 KJ/m2提高到15.41 KJ/m2,提高了约823%;此外,亚麻纤维增强螺旋结构显著提高了树脂的极限抗拉强度,其中亚麻纤维90°层间角增强最大,从5.32 MPa增加到19.45 MPa。
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引用次数: 0
HFSOF: A Hierarchical Feature Selection and Optimization Framework for Ultrasound-Based Diagnosis of Endometrial Lesions. 超声诊断子宫内膜病变的分级特征选择和优化框架。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-15 DOI: 10.3390/biomimetics11010074
Yongjun Liu, Zihao Zhang, Tongyu Chai, Haitong Zhao

Endometrial lesions are common in gynecology, exhibiting considerable clinical heterogeneity across different subtypes. Although ultrasound imaging is the preferred diagnostic modality due to its noninvasive, accessible, and cost-effective nature, its diagnostic performance remains highly operator-dependent, leading to subjectivity and inconsistent results. To address these limitations, this study proposes a hierarchical feature selection and optimization framework for endometrial lesions, aiming to enhance the objectivity and robustness of ultrasound-based diagnosis. Firstly, Kernel Principal Component Analysis (KPCA) is employed for nonlinear dimensionality reduction, retaining the top 1000 principal components. Secondly, an ensemble of three filter-based methods-information gain, chi-square test, and symmetrical uncertainty-is integrated to rank and fuse features, followed by thresholding with Maximum Scatter Difference Linear Discriminant Analysis (MSDLDA) for preliminary feature selection. Finally, the Whale Migration Algorithm (WMA) is applied to population-based feature optimization and classifier training under the constraints of a Support Vector Machine (SVM) and a macro-averaged F1 score. Experimental results demonstrate that the proposed closed-loop pipeline of "kernel reduction-filter fusion-threshold pruning-intelligent optimization-robust classification" effectively balances nonlinear structure preservation, feature redundancy control, and model generalization, providing an interpretable, reproducible, and efficient solution for intelligent diagnosis in small- to medium-scale medical imaging datasets.

子宫内膜病变在妇科很常见,在不同亚型中表现出相当大的临床异质性。虽然超声成像是首选的诊断方式,因为它的无创性,可及性和成本效益的性质,其诊断性能仍然高度依赖于操作者,导致主观性和不一致的结果。为了解决这些局限性,本研究提出了子宫内膜病变分层特征选择和优化框架,旨在提高超声诊断的客观性和稳健性。首先,采用核主成分分析(KPCA)进行非线性降维,保留前1000个主成分;其次,综合信息增益、卡方检验和对称不确定性三种滤波方法对特征进行排序和融合,然后使用最大散差线性判别分析(MSDLDA)进行阈值分割进行初步特征选择。最后,在支持向量机(SVM)和宏观平均F1分数的约束下,将鲸鱼迁移算法(WMA)应用于基于种群的特征优化和分类器训练。实验结果表明,所提出的“核约简-滤波融合-阈值剪枝-智能优化-鲁棒分类”闭环管道有效地平衡了非线性结构保留、特征冗余控制和模型泛化,为中小规模医学影像数据集的智能诊断提供了可解释、可重复、高效的解决方案。
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引用次数: 0
Enhanced Educational Optimization Algorithm Based on Student Psychology for Global Optimization Problems and Real Problems. 基于学生心理的全局优化与现实问题改进教育优化算法
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-14 DOI: 10.3390/biomimetics11010070
Wenyu Miao, Katherine Lin Shu, Xiao Yang

To address the insufficient exploration ability, susceptibility to local optima, and limited convergence accuracy of the standard Student Psychology-Based Optimization (SPBO) algorithm in three-dimensional UAV trajectory planning, we propose an enhanced variant, Enhanced SPBO (ESPBO). ESPBO augments SPBO with three complementary strategies: (i) Time-Adaptive Scheduling, which uses normalized time (τ=t/T) to schedule global step-size shrinking, Gaussian fine-tuning, and Lévy flight intensity, enabling strong early exploration and fine late-stage exploitation; (ii) Mentor Pool Guidance, which selects a top-K mentor set and applies time-varying guidance weights to reduce misleading attraction and improve directional stability; and (iii) Directional Jump Exploration, which couples a differential vector with Lévy flights to strengthen basin-crossing while keeping the differential step bounded for robustness. Numerical experiments on CEC2017, CEC2020 and CEC2022 benchmark functions compare ESPBO with Grey Wolf Optimization (GWO), Whale Optimization Algorithm (WOA), Improved multi-strategy adaptive Grey Wolf Optimization (IAGWO), Dung Beetle Optimization (DBO), Snake Optimization (SO), Rime Optimization (RIME), and the original SPBO. We evaluate best path length, mean trajectory length, standard deviation, and convergence curves and assess statistical stability via Wilcoxon rank-sum tests (p = 0.05) and the Friedman test. ESPBO significantly outperforms the comparison algorithms in path-planning accuracy and convergence stability, ranking first on both test suites. Applied to 3D UAV trajectory planning in mountainous terrain with no-fly zones, ESPBO achieves an optimal path length of 199.8874 m, an average path length of 205.8179 m, and a standard deviation of 5.3440, surpassing all baselines; notably, ESPBO's average path length is even lower than the optimal path length of other algorithms. These results demonstrate that ESPBO provides an efficient and robust solution for UAV trajectory optimization in intricate environments and extends the application of swarm intelligence algorithms in autonomous navigation.

针对标准的基于学生心理的优化算法(SPBO)在无人机三维轨迹规划中存在探索能力不足、易受局部最优影响以及收敛精度有限的问题,提出了一种改进的基于学生心理的优化算法(ESPBO)。ESPBO对SPBO有三个互补策略:(i)时间自适应调度,利用归一化时间(τ=t/ t)调度全局步长缩减、高斯微调和lsamvy飞行强度,实现早期强勘探和后期精细开发;(ii)导师池制导(Mentor Pool Guidance),选择top-K的导师集,采用时变制导权,减少误导吸引力,提高方向稳定性;(iii)定向跳跃探索(Directional Jump Exploration),它将微分向量与lsamvy飞行耦合在一起,以加强盆地穿越,同时保持微分步长有界以保持鲁棒性。在CEC2017、CEC2020和CEC2022基准函数上进行数值实验,将ESPBO与灰狼优化算法(GWO)、鲸鱼优化算法(WOA)、改进多策略自适应灰狼优化算法(IAGWO)、屎壳虫优化算法(DBO)、蛇形优化算法(SO)、Rime优化算法(Rime)和原始SPBO进行比较。我们评估最佳路径长度、平均轨迹长度、标准差和收敛曲线,并通过Wilcoxon秩和检验(p = 0.05)和Friedman检验评估统计稳定性。ESPBO在路径规划精度和收敛稳定性方面都明显优于比较算法,在两个测试套件中均排名第一。应用于山地禁飞区地形的三维无人机轨迹规划,ESPBO优化路径长度为199.8874 m,平均路径长度为205.8179 m,标准差为5.3440,优于所有基线;值得注意的是,ESPBO的平均路径长度甚至低于其他算法的最优路径长度。结果表明,ESPBO算法为复杂环境下的无人机轨迹优化提供了高效、鲁棒的解决方案,扩展了群智能算法在自主导航中的应用。
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引用次数: 0
Black-Winged Kite Algorithm Integrating Opposition-Based Learning and Quasi-Newton Strategy. 结合对立学习与拟牛顿策略的黑翼风筝算法。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-14 DOI: 10.3390/biomimetics11010068
Ning Zhao, Tinghua Wang, Yating Zhu

To address the deficiencies in global search capability and population diversity decline of the black-winged kite algorithm (BKA), this paper proposes an enhanced black-winged kite algorithm integrating opposition-based learning and quasi-Newton strategy (OQBKA). The algorithm introduces a mirror imaging strategy based on convex lens imaging (MOBL) during the migration phase to enhance the population's spatial distribution and assist individuals in escaping local optima. In later iterations, it incorporates the quasi-Newton method to enhance local optimization precision and convergence performance. Ablation studies on the CEC2017 benchmark set confirm the strong complementarity between the two integrated strategies, with OQBKA achieving an average ranking of 1.34 across all 29 test functions. Comparative experiments on the CEC2022 benchmark suite further verify its superior exploration-exploitation balance and optimization accuracy: under 10- and 20-dimensional settings, OQBKA attains the best average rankings of 2.5 and 2.17 across all 12 test functions, outperforming ten state-of-the-art metaheuristic algorithms. Moreover, evaluations on three constrained engineering design problems, including step-cone pulley optimization, corrugated bulkhead design, and reactor network design, demonstrate the practicality and robustness of the proposed approach in generating feasible solutions under complex constraints.

针对黑翼风筝算法(BKA)全局搜索能力不足和种群多样性下降的问题,提出了一种基于对立学习和准牛顿策略(OQBKA)的增强黑翼风筝算法。该算法在迁移阶段引入基于凸透镜成像(MOBL)的镜像成像策略,增强种群的空间分布,帮助个体逃离局部最优。在后续迭代中,引入拟牛顿方法,提高局部寻优精度和收敛性能。在CEC2017基准集上的消融研究证实了两种集成策略之间的强互补性,OQBKA在所有29个测试功能中获得了1.34的平均排名。在CEC2022基准测试套件上的对比实验进一步验证了其优越的勘探开发平衡性和优化精度:在10维和20维设置下,OQBKA在所有12个测试功能中获得了2.5和2.17的最佳平均排名,优于10种最先进的元启发式算法。此外,通过对阶梯锥轮优化、波纹舱壁设计和反应堆网络设计等三个约束工程设计问题的评估,证明了该方法在复杂约束条件下生成可行解的实用性和鲁棒性。
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引用次数: 0
Large-Scale Multi-UAV Task Allocation via a Centrality-Driven Load-Aware Adaptive Consensus Bundle Algorithm for Biomimetic Swarm Coordination. 基于中心性驱动负载感知自适应共识束算法的大规模多无人机任务分配。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-14 DOI: 10.3390/biomimetics11010069
Weifei Gan, Hongxuan Xu, Yunwei Bai, Xin Zhou, Wangyu Wu, Xiaofei Du

Large multi-UAV mission systems operate over time-varying communication graphs with heterogeneous platforms, where classical distributed task assignment may incur excessive message passing and suboptimal task-resource matching. To address these challenges, this paper proposes CLAC-CBBA (Centrality-Driven and Load-Aware Adaptive Clustering CBBA), an enhanced variant of the Consensus-Based Bundle Algorithm (CBBA) for large heterogeneous swarms. The proposed method is biomimetic in the sense that it integrates swarm-inspired self-organization and load-aware self-regulation to improve scalability and robustness, resembling decentralized role emergence and negative-feedback workload balancing in natural swarms. Specifically, CLAC-CBBA first identifies key nodes via a centrality-based adaptive cluster-reconfiguration mechanism (CenCluster) and partitions the network into cooperation domains to reduce redundant communication. It then applies a load-aware cluster self-regulation mechanism (LCSR), which combines resource attributes and spatial information, uses K-medoids clustering, and triggers split/merge reconfiguration based on real-time load imbalance. CBBA bidding is executed locally within clusters, while anchors and cluster representatives synchronize winners/bids to ensure globally consistent, conflict-free assignments. Simulations across diverse network densities and swarm sizes show that CLAC-CBBA reduces communication overhead and runtime while improving total task score compared with CBBA and several advanced variants, with statistically significant gains. These results demonstrate that CLAC-CBBA is scalable and robust for large-scale heterogeneous UAV task allocation.

大型多无人机任务系统运行在异构平台的时变通信图上,传统的分布式任务分配可能导致消息传递过多和任务资源匹配不理想。为了解决这些挑战,本文提出了CLAC-CBBA(中心性驱动和负载感知自适应聚类CBBA),这是基于共识的束算法(CBBA)的增强版本,适用于大型异构群集。所提出的方法是仿生的,它集成了群体启发的自组织和负载感知的自我调节,以提高可扩展性和鲁棒性,类似于自然群体中的分散角色出现和负反馈工作负载平衡。具体而言,CLAC-CBBA首先通过基于中心性的自适应集群重构机制(CenCluster)识别关键节点,并将网络划分为多个合作域,以减少冗余通信。然后应用负载感知集群自我调节机制(LCSR),该机制结合资源属性和空间信息,使用k - medioids聚类,并基于实时负载不平衡触发拆分/合并重新配置。CBBA投标在本地集群内执行,而锚点和集群代表同步中标者/投标,以确保全球一致,无冲突的分配。不同网络密度和群大小的模拟表明,与CBBA和几个高级变体相比,CLAC-CBBA减少了通信开销和运行时间,同时提高了总任务得分,具有统计学上显著的收益。结果表明,CLAC-CBBA算法对于大规模异构无人机任务分配具有可扩展性和鲁棒性。
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引用次数: 0
Research Progress on Biomimetic Water Collection Materials. 仿生集水材料的研究进展。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-13 DOI: 10.3390/biomimetics11010067
Hengyu Pan, Lingmei Zhu, Huijie Wei, Tiance Zhang, Boyang Tian, Jianhua Wang, Yongping Hou, Yongmei Zheng

Water scarcity constitutes a major global challenge. Biomimetic water collection materials, which mimic the efficient water capture and transport mechanisms, offer a crucial approach to addressing the water crisis. This review summarizes the research progress on biomimetic water collection materials, focusing on biological prototypes, operational mechanisms, and core aspects of biomimetic design. Typical water-collecting biological surfaces in nature exhibit distinctive structure-function synergy: spider silk achieves directional droplet transport via periodic spindle-knot structures, utilizing Laplace pressure difference and surface energy gradient; the desert beetle's back features hydrophilic microstructures and a hydrophobic waxy coating, forming a fog-water collection system based on heterogeneous wettability; cactus spines enhance droplet transport efficiency through the synergy of gradient grooves and barbs; and shorebird beaks enable rapid water convergence via liquid bridge effects. These biological prototypes provide vital inspiration for the design of biomimetic water collection materials. Drawing on biological mechanisms, researchers have developed diverse biomimetic water collection materials. This review offers a theoretical reference for their structural design and performance enhancement, highlighting bio-inspiration's core value in high-efficiency water collection material development. Additionally, this paper discusses challenges and opportunities of these materials, providing insights for advancing the engineering application of next-generation high-efficiency biomimetic water collection materials.

水资源短缺是一项重大的全球挑战。仿生水收集材料,模仿有效的水捕获和运输机制,为解决水危机提供了一个重要的方法。本文综述了仿生集水材料的研究进展,重点介绍了仿生集水材料的生物原型、运行机制和仿生设计的核心方面。典型的自然集水生物表面表现出独特的结构-功能协同作用:蛛丝利用拉普拉斯压差和表面能梯度,通过周期性纺锤结结构实现液滴定向输送;沙漠甲虫背部具有亲水性微结构和疏水性蜡质涂层,形成基于非均相润湿性的雾水收集系统;仙人掌刺通过梯度凹槽和倒刺的协同作用提高液滴的输送效率;水鸟的喙通过液体桥效应使水快速汇聚。这些生物原型为仿生集水材料的设计提供了重要的灵感。利用生物机制,研究人员开发了多种仿生集水材料。本文综述为其结构设计和性能提升提供了理论参考,突出了生物灵感在高效集水材料开发中的核心价值。此外,本文还讨论了这些材料面临的挑战和机遇,为推进下一代高效仿生集水材料的工程应用提供了见解。
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引用次数: 0
Collagen Type I as a Biological Barrier Interface in Biomimetic Microfluidic Devices: Properties, Applications, and Challenges. I型胶原蛋白作为仿生微流控装置中的生物屏障界面:特性、应用和挑战。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-13 DOI: 10.3390/biomimetics11010066
Valentina Grumezescu, Liviu Duta

Collagen type I has become a practical cornerstone for constructing biologically meaningful barrier interfaces in microfluidic systems. Its fibrillar architecture, native ligand display, and susceptibility to cell-mediated remodeling support epithelial and endothelial polarization, tight junctions, and transport behaviors that are difficult to achieve with purely synthetic barrier interfaces. Recent advances pair these biological strengths with tighter engineering control. For example, ultrathin collagen barriers (tens of micrometers or less) enable faster molecular exchange and short-range signaling; gentle crosslinking and composite designs limit gel compaction and delamination under flow; and patterning/bioprinting introduce alignment, graded porosity, and robust integration into device geometries. Applications now span intestine, vasculature, skin, airway, kidney, and tumor-stroma interfaces, with readouts including transepithelial/transendothelial electrical resistance (TEER), tracer permeability, and image-based quality control of fiber architecture. Persistent constraints include batch variability, long-term mechanical drift, limited standardization of fibrillogenesis conditions, and difficulties scaling fabrication without loss of bioactivity. Priorities include reporting standards for microstructure and residual crosslinker, chips for continuous monitoring, immune-competent co-cultures, and closer collaboration across materials science, microfabrication, computational modelling, and clinical pharmacology. Thus, this review synthesizes the state-of-the-art and offers practical guidance on technological readiness and future directions for using collagen type I as a biological barrier interface in biomimetic microfluidic systems.

I型胶原蛋白已成为构建微流体系统中具有生物学意义的屏障界面的实用基石。其纤维结构、天然配体展示和对细胞介导重塑的易感性支持上皮和内皮细胞极化、紧密连接和运输行为,这是纯合成屏障界面难以实现的。最近的进展将这些生物优势与更严格的工程控制结合起来。例如,超薄的胶原蛋白屏障(几十微米或更小)可以实现更快的分子交换和短距离信号传导;温和的交联和复合设计限制了凝胶在流动下的压实和分层;而图案/生物打印则引入了对齐、分级孔隙度和与设备几何形状的强大集成。目前的应用范围涵盖肠道、血管系统、皮肤、气道、肾脏和肿瘤基质界面,其读数包括经上皮/经内皮电阻(TEER)、示踪剂渗透性和基于图像的纤维结构质量控制。持续的限制包括批变异性、长期的机械漂移、纤维形成条件的有限标准化,以及在不丧失生物活性的情况下缩放制造的困难。优先事项包括微观结构和剩余交联剂的报告标准,连续监测芯片,免疫能力共培养,以及材料科学,微制造,计算建模和临床药理学之间的更密切合作。因此,这篇综述综合了最新的技术,并为在仿生微流体系统中使用I型胶原蛋白作为生物屏障界面的技术准备和未来方向提供了实用的指导。
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引用次数: 0
A Modified Artificial Protozoa Optimizer for Robust Parameter Identification in Nonlinear Dynamic Systems. 一种用于非线性动态系统鲁棒参数辨识的改进人工原生动物优化器。
IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-12 DOI: 10.3390/biomimetics11010065
Davut Izci, Serdar Ekinci, Gökhan Yüksek, Mostafa Rashdan, Burcu Bektaş Güneş, Muhammet İsmail Güngör, Mohammad Salman

Accurate parameter identification in nonlinear and chaotic dynamic systems requires optimization algorithms that can reliably balance global exploration and local refinement in complex, multimodal search landscapes. To address this challenge, a modified artificial protozoa optimizer (mAPO) is developed in this study by embedding two complementary mechanisms into the original artificial protozoa optimizer: a probabilistic random learning strategy to enhance population diversity and global search capability, and a Nelder-Mead simplex-based local refinement stage to improve exploitation and fine-scale solution adjustment. The general optimization performance and scalability of the proposed framework are first evaluated using the CEC2017 benchmark suite. Statistical analyses conducted over shifted and rotated, hybrid, and composition functions demonstrate that mAPO achieves improved mean performance and reduced variability compared with the original APO, indicating enhanced robustness in high-dimensional and complex optimization problems. The effectiveness of mAPO is then examined in nonlinear system identification applications involving chaotic dynamics. Offline and online parameter identification experiments are performed on the Rössler chaotic system and a permanent magnet synchronous motor, including scenarios with abrupt parameter variations. Comparative simulations against APO and several state-of-the-art optimizers show that mAPO consistently yields smaller objective function values, more accurate parameter estimates, and superior statistical stability. In the PMSM case, exact parameter reconstruction with zero error is achieved across all independent runs, while rapid and smooth convergence is observed under both static and time-varying conditions.

在非线性和混沌动态系统中,精确的参数识别要求优化算法能够在复杂、多模态的搜索环境中可靠地平衡全局探索和局部优化。为了解决这一挑战,本研究开发了一种改进的人工原生动物优化器(mAPO),将两个互补机制嵌入到原始的人工原生动物优化器中:一个是概率随机学习策略,以增强种群多样性和全局搜索能力;另一个是基于Nelder-Mead简单矩阵的局部细化阶段,以提高开发和精细尺度的解调整能力。首先使用CEC2017基准套件对所提出框架的一般优化性能和可扩展性进行评估。对移位和旋转、混合和组合函数进行的统计分析表明,与原始APO相比,mAPO实现了更高的平均性能和更低的可变性,表明在高维和复杂的优化问题中增强了鲁棒性。然后在涉及混沌动力学的非线性系统辨识应用中检验了mAPO的有效性。在Rössler混沌系统和永磁同步电机上进行了离线和在线参数辨识实验,包括参数突变的场景。与APO和几个最先进的优化器的比较模拟表明,mAPO始终产生更小的目标函数值,更准确的参数估计和更好的统计稳定性。在永磁同步电机的情况下,在所有独立运行中都实现了精确的零误差参数重建,同时在静态和时变条件下都观察到快速平滑的收敛。
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