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Characterization of human aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery. 在酵母表达系统中表征人类 Aquaporin 离子通道,作为发现新型离子通道的工具。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240542
Saeed Nourmohammadi, Sam W Henderson, Sunita A Ramesh, Andrea J Yool

Aquaporin (AQP) channels found in all domains of life are transmembrane proteins which mediate passive transport of water, glycerol, signaling molecules, metabolites, and charged solutes. Discovery of new classes of ion-conducting AQP channels has been slow, likely reflecting time- and labor-intensive methods required for traditional electrophysiology. Work here defines a sensitive mass-throughput system for detecting AQP ion channels, identified by rescue of cell growth in the K+-transport-defective yeast strain CY162 following genetic complementation with heterologously expressed cation-permeable channels, using the well characterized human AQP1 channel for proof of concept. Results showed AQP1 conferred transmembrane permeability to cations which rescued survival in CY162 yeast. Comprehensive testing showed that growth response properties fully recapitulated AQP1 pharmacological agonist and antagonist profiles for activation, inhibition, dose-dependence, and structure-function relationships, demonstrating validity of the yeast screening tool for AQP channel identification and drug discovery efforts. This method also provided new information on divalent cation blockers of AQP1, pH sensitivity of antagonists, and ion permeability of human AQP6. Site-directed mutagenesis of AQP1 channel regulatory domains confirmed that yeast growth rescue was mediated by the introduced channels. Optical monitoring with a lithium-sensitive photoswitchable probe in living cells independently demonstrated monovalent cation permeability of AQP1 channels in yeast plasma membrane. Ion channel properties of AQP1 expressed in yeast were consistent with those of AQP1 expressed in Xenopus laevis oocyte and K+-transport defective Escherichia coli. Outcomes here establish a powerful new approach for efficient screening of phylogenetically diverse AQPs for yet untested functions as cation channels.

存在于所有生命领域的水汽素(AQP)通道是一种跨膜蛋白,它介导水、甘油、信号分子、代谢物和带电溶质的被动运输。离子传导 AQP 通道新类别的发现一直进展缓慢,这可能反映了传统电生理学所需的费时费力的方法。本文的研究工作定义了一种灵敏的高通量系统,用于检测 AQP 离子通道,该系统是通过与异源表达的阳离子渗透通道进行基因互补后挽救 K+ 转运缺陷酵母菌株 CY162 的细胞生长而确定的,并使用特征明显的人类 AQP1 通道作为概念验证。结果表明,AQP1 赋予酵母对阳离子的跨膜通透性,从而挽救了 CY162 酵母菌的存活。综合测试显示,生长反应特性完全再现了 AQP1 在激活、抑制、剂量依赖性和结构功能关系方面的药理激动剂和拮抗剂特性,证明了酵母筛选工具在 AQP 通道鉴定和药物发现方面的有效性。这种方法还提供了有关 AQP1 的二价阳离子阻断剂、拮抗剂的 pH 敏感性和人类 AQP6 的离子渗透性的新信息。AQP1 通道调节结构域的定点突变证实,酵母的生长救援是由引入的通道介导的。在活细胞中使用锂敏感光开关探针进行的光学监测独立地证明了 AQP1 通道在酵母质膜中的单价阳离子通透性。在酵母中表达的 AQP1 的离子通道特性与在爪哇蟾蜍卵母细胞和 K+ 转运缺陷大肠杆菌中表达的 AQP1 的特性一致。这些结果为高效筛选系统发育多样的 AQPs,以确定其作为阳离子通道的功能提供了一种强有力的新方法。
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引用次数: 0
Retraction: Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway. 撤回:机械生长因子通过抑制 p38 MAPK 通路减轻机械过载诱导的髓核细胞凋亡。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-2462_RET
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引用次数: 0
Retraction: Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyper-osmotic environment. 撤回:CDMP-2通过调节高渗透环境下的氧化损伤来减轻髓核细胞凋亡。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1176_RET
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引用次数: 0
Retraction: Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture. 撤回:骨生成蛋白-1在高渗培养中通过激活PI3K/Akt/mTOR途径减轻髓核细胞凋亡
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1708_RET
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引用次数: 0
Retraction: Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture. 撤回:在椎间盘灌注培养中,p38-MAPK通路在高强度挤压对髓核细胞衰老的影响中的作用。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2017-0718_RET
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引用次数: 0
Retraction: The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture. 撤回:椎间盘器官培养中髓核细胞衰老对静态和动态挤压的反应
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-0064_RET
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引用次数: 0
Structural characterization of DNA-binding domain of essential mammalian protein TTF 1. 哺乳动物必需蛋白 TTF 1 DNA 结合域的结构特征。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240800
Gajender Singh, Abhinetra Jagdish Bhopale, Saloni Khatri, Prashant Prakash, Rajnish Kumar, Sukh Mahendra Singh, Samarendra Kumar Singh

Transcription Termination Factor 1 (TTF1) is a multifunctional mammalian protein with vital roles in various cellular processes, including Pol I-mediated transcription initiation and termination, pre-rRNA processing, chromatin remodelling, DNA damage repair, and polar replication fork arrest. It comprises two distinct functional regions; the N-terminal regulatory region (1-445 aa), and the C-terminal catalytic region (445-859 aa). The Myb domain located at the C-terminal region is a conserved DNA binding domain spanning from 550 to 732 aa (183 residues). Despite its critical role in various cellular processes, the physical structure of TTF1 remains unsolved. Attempts to purify the functional TTF1 protein have been unsuccessful till date. Therefore, we focused on characterizing the Myb domain of this essential protein. We started with predicting a 3-D model of the Myb domain using homology modelling, and ab-initio method. We then determined its stability through MD simulation in an explicit solvent. The model predicted is highly stable, which stabilizes at 200ns. To experimentally validate the computational model, we cloned and expressed the codon optimized Myb domain into a bacterial expression vector and purified the protein to homogeneity. Further, characterization of the protein shows that, Myb domain is predominantly helical (65%) and is alone sufficient to bind the Sal Box DNA. This is the first-ever study to report a complete in silico model of the Myb domain, which is physically characterized. The above study will pave the way towards solving the atomic structure of this essential mammalian protein.

转录终止因子 1(TTF1)是一种多功能哺乳动物蛋白,在 Pol I 介导的转录启动和终止、前 RNA 处理、染色质重塑、DNA 损伤修复和极性复制叉停滞等多种细胞过程中发挥着重要作用。它由两个不同的功能区组成:N 端调节区(1-445 aa)和 C 端催化区(445-859 aa)。位于 C 端的 Myb 结构域是一个保守的 DNA 结合结构域,跨度从 550 到 732 aa(183 个残基)。尽管 TTF1 在各种细胞过程中发挥着关键作用,但其物理结构仍未得到解决。迄今为止,纯化功能性 TTF1 蛋白的尝试尚未成功。因此,我们重点研究了这种重要蛋白质的 Myb 结构域。我们首先使用同源建模和非线性方法预测了 Myb 结构域的三维模型。 然后,我们在显式溶剂中通过 MD 模拟确定了它的稳定性。预测出的模型高度稳定,在 200ns 时稳定下来。为了在实验中验证计算模型,我们将经过密码子优化的 Myb 结构域克隆并表达到细菌表达载体中,并将蛋白质纯化至均一。此外,对蛋白质的表征显示,Myb结构域主要是螺旋结构(65%),仅此就足以与Sal Box DNA结合。这是有史以来第一份报告完整的 Myb 结构域硅模型的研究报告,该模型具有物理特征。上述研究将为解决这一哺乳动物重要蛋白质的原子结构问题铺平道路。
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引用次数: 0
Transglutaminase 2-mediated histone monoaminylation and its role in cancer. 转谷氨酰胺酶 2 介导的组蛋白单氨酰化及其在癌症中的作用
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240493
Huapeng Li, Jinghua Wu, Nan Zhang, Qingfei Zheng

Transglutaminase 2 (TGM2) has been known as a well-characterized factor regulating the progression of multiple types of cancer, due to its multifunctional activities and the ubiquitous signaling pathways it is involved in. As a member of the transglutaminase family, TGM2 catalyzes protein post-translational modifications (PTMs), including monoaminylation, amide hydrolysis, cross-linking, etc., through the transamidation of variant glutamine-containing protein substrates. Recent discoveries revealed histone as an important category of TGM2 substrates, thus identifying histone monoaminylation as an emerging epigenetic mark, which is highly enriched in cancer cells and possesses significant regulatory functions of gene transcription. In this review, we will summarize recent advances in TGM2-mediated histone monoaminylation as well as its role in cancer and discuss the key research methodologies to better understand this unique epigenetic mark, thereby shedding light on the therapeutic potential of TGM2 as a druggable target in cancer treatment.

转谷氨酰胺酶 2(TGM2)因其多功能活性及其参与的无处不在的信号通路而被认为是调节多种类型癌症进展的特征明显的因子。作为转谷氨酰胺酶家族的一员,TGM2 通过对含变体谷氨酰胺的蛋白质底物进行反酰胺化,催化蛋白质翻译后修饰(PTM),包括单酰胺化、酰胺水解、交联等。最近的发现揭示了组蛋白是 TGM2 底物的一个重要类别,从而确定了组蛋白单氨化是一种新兴的表观遗传标记,在癌细胞中高度富集,对基因转录具有重要的调控功能。在这篇综述中,我们将总结 TGM2 介导的组蛋白单氨化及其在癌症中的作用的最新进展,并讨论更好地理解这一独特的表观遗传标记的关键研究方法,从而揭示 TGM2 作为癌症治疗药物靶点的治疗潜力。
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引用次数: 0
Retraction: Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MPAK pathway. 撤回:酸性 pH 通过激活 p38 MPAK 通路促进细胞核衰老
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1451_RET
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引用次数: 0
Retraction: High-glucose environment accelerates annulus fibrosus cell apoptosis by regulating endoplasmic reticulum stress. 撤回:高糖环境通过调节内质网应激加速环状纤维肌细胞凋亡
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2020-0262_RET
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引用次数: 0
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