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Retraction: Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture. 撤回:骨生成蛋白-1在高渗培养中通过激活PI3K/Akt/mTOR途径减轻髓核细胞凋亡
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1708_RET
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引用次数: 0
Retraction: Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture. 撤回:在椎间盘灌注培养中,p38-MAPK通路在高强度挤压对髓核细胞衰老的影响中的作用。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2017-0718_RET
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引用次数: 0
Retraction: The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture. 撤回:椎间盘器官培养中髓核细胞衰老对静态和动态挤压的反应
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-0064_RET
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引用次数: 0
Structural characterization of DNA-binding domain of essential mammalian protein TTF 1. 哺乳动物必需蛋白 TTF 1 DNA 结合域的结构特征。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240800
Gajender Singh, Abhinetra Jagdish Bhopale, Saloni Khatri, Prashant Prakash, Rajnish Kumar, Sukh Mahendra Singh, Samarendra Kumar Singh

Transcription Termination Factor 1 (TTF1) is a multifunctional mammalian protein with vital roles in various cellular processes, including Pol I-mediated transcription initiation and termination, pre-rRNA processing, chromatin remodelling, DNA damage repair, and polar replication fork arrest. It comprises two distinct functional regions; the N-terminal regulatory region (1-445 aa), and the C-terminal catalytic region (445-859 aa). The Myb domain located at the C-terminal region is a conserved DNA binding domain spanning from 550 to 732 aa (183 residues). Despite its critical role in various cellular processes, the physical structure of TTF1 remains unsolved. Attempts to purify the functional TTF1 protein have been unsuccessful till date. Therefore, we focused on characterizing the Myb domain of this essential protein. We started with predicting a 3-D model of the Myb domain using homology modelling, and ab-initio method. We then determined its stability through MD simulation in an explicit solvent. The model predicted is highly stable, which stabilizes at 200ns. To experimentally validate the computational model, we cloned and expressed the codon optimized Myb domain into a bacterial expression vector and purified the protein to homogeneity. Further, characterization of the protein shows that, Myb domain is predominantly helical (65%) and is alone sufficient to bind the Sal Box DNA. This is the first-ever study to report a complete in silico model of the Myb domain, which is physically characterized. The above study will pave the way towards solving the atomic structure of this essential mammalian protein.

转录终止因子 1(TTF1)是一种多功能哺乳动物蛋白,在 Pol I 介导的转录启动和终止、前 RNA 处理、染色质重塑、DNA 损伤修复和极性复制叉停滞等多种细胞过程中发挥着重要作用。它由两个不同的功能区组成:N 端调节区(1-445 aa)和 C 端催化区(445-859 aa)。位于 C 端的 Myb 结构域是一个保守的 DNA 结合结构域,跨度从 550 到 732 aa(183 个残基)。尽管 TTF1 在各种细胞过程中发挥着关键作用,但其物理结构仍未得到解决。迄今为止,纯化功能性 TTF1 蛋白的尝试尚未成功。因此,我们重点研究了这种重要蛋白质的 Myb 结构域。我们首先使用同源建模和非线性方法预测了 Myb 结构域的三维模型。 然后,我们在显式溶剂中通过 MD 模拟确定了它的稳定性。预测出的模型高度稳定,在 200ns 时稳定下来。为了在实验中验证计算模型,我们将经过密码子优化的 Myb 结构域克隆并表达到细菌表达载体中,并将蛋白质纯化至均一。此外,对蛋白质的表征显示,Myb结构域主要是螺旋结构(65%),仅此就足以与Sal Box DNA结合。这是有史以来第一份报告完整的 Myb 结构域硅模型的研究报告,该模型具有物理特征。上述研究将为解决这一哺乳动物重要蛋白质的原子结构问题铺平道路。
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引用次数: 0
Transglutaminase 2-mediated histone monoaminylation and its role in cancer. 转谷氨酰胺酶 2 介导的组蛋白单氨酰化及其在癌症中的作用
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240493
Huapeng Li, Jinghua Wu, Nan Zhang, Qingfei Zheng

Transglutaminase 2 (TGM2) has been known as a well-characterized factor regulating the progression of multiple types of cancer, due to its multifunctional activities and the ubiquitous signaling pathways it is involved in. As a member of the transglutaminase family, TGM2 catalyzes protein post-translational modifications (PTMs), including monoaminylation, amide hydrolysis, cross-linking, etc., through the transamidation of variant glutamine-containing protein substrates. Recent discoveries revealed histone as an important category of TGM2 substrates, thus identifying histone monoaminylation as an emerging epigenetic mark, which is highly enriched in cancer cells and possesses significant regulatory functions of gene transcription. In this review, we will summarize recent advances in TGM2-mediated histone monoaminylation as well as its role in cancer and discuss the key research methodologies to better understand this unique epigenetic mark, thereby shedding light on the therapeutic potential of TGM2 as a druggable target in cancer treatment.

转谷氨酰胺酶 2(TGM2)因其多功能活性及其参与的无处不在的信号通路而被认为是调节多种类型癌症进展的特征明显的因子。作为转谷氨酰胺酶家族的一员,TGM2 通过对含变体谷氨酰胺的蛋白质底物进行反酰胺化,催化蛋白质翻译后修饰(PTM),包括单酰胺化、酰胺水解、交联等。最近的发现揭示了组蛋白是 TGM2 底物的一个重要类别,从而确定了组蛋白单氨化是一种新兴的表观遗传标记,在癌细胞中高度富集,对基因转录具有重要的调控功能。在这篇综述中,我们将总结 TGM2 介导的组蛋白单氨化及其在癌症中的作用的最新进展,并讨论更好地理解这一独特的表观遗传标记的关键研究方法,从而揭示 TGM2 作为癌症治疗药物靶点的治疗潜力。
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引用次数: 0
Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro, effects of LDL in chemoresistance. 他莫昔芬代谢物在体外促进ERα+向三阴性表型转变,LDL在化疗耐药性中的作用。
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR20240444
Andrea Muñoz-Ayala, Brenda Chimal-Vega, Nicolás Serafín-Higuera, Octavio Galindo-Hernández, Gladys Ramírez-Rosales, Iván Córdova-Guerrero, Luis Fernando Gómez-Lucas, Victor García-González

Objective: Estrogen receptor-positive (ER+) breast cancer represents about 80% of cases, tamoxifen is the election neoadjuvant chemotherapy. However, a large percentage of patients develop chemoresistance, compromising recovery. Clinical evidence suggests that high plasmatic levels of low-density lipoproteins (LDL) could promote cancer progression. The present study analyzed the effect of LDL on the primary plasmatic active Tamoxifen's metabolites resistance acquisition, 4-hydroxytamoxifen (4OH-Tam) and 4-hydroxy-N-desmethyl-tamoxifen (endoxifen), in breast cancer ERα + cells (MCF-7).

Methods: Two resistant cellular variants, MCF-7Var-H and MCF-7Var-I, were generated by a novel strategy and their phenotype features were evaluated. Phenotypic assessment was performed by MTT assays, cytometry, immunofluorescence microscopy, zymography and protein expression analysis.

Results: MCF-7Var-H, generated only with tamoxifen metabolites, showed a critical down-regulation in hormone receptors, augmented migration capacity, metalloprotease 9 extracellular medium excretion, and a mesenchymal morphology in contrast with native MCF-7, suggesting the transition towards Triple-negative breast cancer (TNBC) phenotype. In contrast, MCF-7Var-I which was generated in a high LDL media, showed only a slight upregulation in ER and other less noticeable metabolic adaptations. Results suggest a potential role of transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in phenotypic differences observed among variants.

Conclusion: LDL high or low concentrations during Tamoxifen´s metabolites chemoresistance acquisition leads to different cellular mechanisms related to chemoresistance. A novel adaptative cellular response associated with Nrf2 activity could be implicated.

目的:雌激素受体阳性(ER+)乳腺癌约占 80%,他莫昔芬是首选的新辅助化疗药物。然而,很大一部分患者会产生化疗耐药性,影响康复。临床证据表明,血浆中高水平的低密度脂蛋白(LDL)会促进癌症进展。本研究分析了低密度脂蛋白对乳腺癌ER+细胞(MCF-7)中主要浆液活性他莫昔芬代谢物--4-羟基他莫昔芬(4OH-Tam)和4-羟基-N-去甲基他莫昔芬(endoxifen)--耐药性获得的影响:方法:通过一种新策略生成了两种耐药细胞变体 MCF-7Var-H 和 MCF-7Var-I,并对它们的表型特征进行了评估。表型评估通过 MTT 检测、细胞测定法、免疫荧光显微镜、酶联免疫图谱和蛋白质表达分析进行:结果:仅用他莫昔芬代谢物生成的 MCF-7Var-H 与原生 MCF-7 相比,激素受体严重下调,迁移能力增强,金属蛋白酶 9 细胞外介质排泄量增加,形态呈间充质,表明向三阴性乳腺癌(TNBC)表型过渡。相比之下,在高低密度脂蛋白培养基中生成的 MCF-7Var-I 仅表现出ER的轻微上调和其他不太明显的代谢适应性。研究结果表明,转录因子核因子红细胞2相关因子2(Nrf2)在不同变体的表型差异中可能发挥了作用:结论:在他莫昔芬代谢物化疗耐药性获得过程中,低密度脂蛋白的高浓度或低浓度会导致与化疗耐药性相关的不同细胞机制。这可能与一种与 Nrf2 活性相关的新型适应性细胞反应有关。
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引用次数: 0
Retraction: Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MPAK pathway. 撤回:酸性 pH 通过激活 p38 MPAK 通路促进细胞核衰老
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1451_RET
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引用次数: 0
Retraction: High-glucose environment accelerates annulus fibrosus cell apoptosis by regulating endoplasmic reticulum stress. 撤回:高糖环境通过调节内质网应激加速环状纤维肌细胞凋亡
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2020-0262_RET
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引用次数: 0
Retraction: Bone morphogenetic protein-7 retards cell subculture-induced senescence of human nucleus pulposus cells through activating the PI3K/Akt pathway. 撤回:骨形态发生蛋白-7通过激活PI3K/Akt通路延缓细胞亚培养诱导的人髓核细胞衰老
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-2312_RET
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引用次数: 0
Retraction: Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment. 撤回:骨生成蛋白-1在炎症环境中通过调节NF-κB/ROS通路抑制髓核细胞凋亡
IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-08-28 DOI: 10.1042/BSR-2018-1530_RET
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引用次数: 0
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