Pub Date : 2019-04-15DOI: 10.1364/boda.2019.jt4a.14
M. Manzo, O. Cavazos
We demonstrate a novel neurotransducer for nerve cells electric potential detection that is based on voltage sensitive dye coupled to a microlaser. The neurotransducer exhibits a sensitivity of Δλ/ΔE=−5*10−4nm/(V/m) and a resolution of 34 V/m.
{"title":"Neurotransducers Based Voltage Sensitive Dye-Doped Microlasers","authors":"M. Manzo, O. Cavazos","doi":"10.1364/boda.2019.jt4a.14","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.14","url":null,"abstract":"We demonstrate a novel neurotransducer for nerve cells electric potential detection that is based on voltage sensitive dye coupled to a microlaser. The neurotransducer exhibits a sensitivity of Δλ/ΔE=−5*10−4nm/(V/m) and a resolution of 34 V/m.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82992425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efficient translation of nanoparticles using optical tweezers (OT) is critical in OT-based methods such as micro- and nano-assembly. We investigate the limits of OT nanoparticle manipulation, achieving record lateral translation speeds of ~ 0.17 mm/s.
{"title":"Theoretical Limits of Nanoparticle Optical Manipulation","authors":"J. Melzer, E. Mcleod","doi":"10.1364/oma.2019.am3e.2","DOIUrl":"https://doi.org/10.1364/oma.2019.am3e.2","url":null,"abstract":"Efficient translation of nanoparticles using optical tweezers (OT) is critical in OT-based methods such as micro- and nano-assembly. We investigate the limits of OT nanoparticle manipulation, achieving record lateral translation speeds of ~ 0.17 mm/s.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83317760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong-le Pan, Aimable Kalume, Z. Gong, Chuji Wang, J. Santarpia
A new universal optical-trapping (UOT) technology was developed. Physical, chemical and biological properties and their evolving dynamics from single UOT airborne particles were studied using position-resolved temporal Raman spectroscopy, back-scattering patterns, and cavity ringdown spectroscopy.
{"title":"Study of single airborne particle using laser spectroscopy and universal optical-trapping","authors":"Yong-le Pan, Aimable Kalume, Z. Gong, Chuji Wang, J. Santarpia","doi":"10.1364/oma.2019.aw1e.3","DOIUrl":"https://doi.org/10.1364/oma.2019.aw1e.3","url":null,"abstract":"A new universal optical-trapping (UOT) technology was developed. Physical, chemical and biological properties and their evolving dynamics from single UOT airborne particles were studied using position-resolved temporal Raman spectroscopy, back-scattering patterns, and cavity ringdown spectroscopy.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87646796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report an optical manipulation method based on an optothermal surface bubble. Nanogap-rich structures that are fabricated with this method are used to detect chemical substance down to femtomolar concentrations.
{"title":"Optical manipulation with an optothermal surface bubble for ultrasensitive sensing","authors":"Chenglong Zhao","doi":"10.1364/OMA.2019.AW2E.3","DOIUrl":"https://doi.org/10.1364/OMA.2019.AW2E.3","url":null,"abstract":"We report an optical manipulation method based on an optothermal surface bubble. Nanogap-rich structures that are fabricated with this method are used to detect chemical substance down to femtomolar concentrations.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76472106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-15DOI: 10.1364/BODA.2019.JT4A.41
R. Chowdhary, Junjie Yao
Vessel segmentation algorithms in photoacoustic images suffer from discontinued vessels. We developed a supervised learning algorithm that determines vessels and non-vessels. Our results indicated our algorithm can determine more microvasculature.
{"title":"Supervised Learning: How Training Detects Microvasculature in Photoacoustic Images","authors":"R. Chowdhary, Junjie Yao","doi":"10.1364/BODA.2019.JT4A.41","DOIUrl":"https://doi.org/10.1364/BODA.2019.JT4A.41","url":null,"abstract":"Vessel segmentation algorithms in photoacoustic images suffer from discontinued vessels. We developed a supervised learning algorithm that determines vessels and non-vessels. Our results indicated our algorithm can determine more microvasculature.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87914030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-15DOI: 10.1364/boda.2019.jt4a.37
E. Nippolainen, R. Shaikh, V. Virtanen, L. Rieppo, I. Afara, S. Saarakkala, J. Töyräs
In this study, we demonstrate the potential of mid-infrared (MIR) and near infrared (NIR) spectroscopies to reveal and differentiate between superficial changes in articular cartilage (AC) after mechanical or enzymatic degradation.
{"title":"Mid-infrared and Near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage","authors":"E. Nippolainen, R. Shaikh, V. Virtanen, L. Rieppo, I. Afara, S. Saarakkala, J. Töyräs","doi":"10.1364/boda.2019.jt4a.37","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.37","url":null,"abstract":"In this study, we demonstrate the potential of mid-infrared (MIR) and near infrared (NIR) spectroscopies to reveal and differentiate between superficial changes in articular cartilage (AC) after mechanical or enzymatic degradation.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82793316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Pérez García, J. Pérez, G. Volpe, A. Arzola, G. Volpe
We propose an algorithm to retrieve the conservative and non-conservative components of a force field acting on a Brownian particle from the analysis of its displacements with important advantages over established techniques.
{"title":"FORMA: Force Reconstruction via Maximum-likelihood-estimator Analysis","authors":"Laura Pérez García, J. Pérez, G. Volpe, A. Arzola, G. Volpe","doi":"10.1364/oma.2019.at2e.2","DOIUrl":"https://doi.org/10.1364/oma.2019.at2e.2","url":null,"abstract":"We propose an algorithm to retrieve the conservative and non-conservative components of a force field acting on a Brownian particle from the analysis of its displacements with important advantages over established techniques.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77215475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-15DOI: 10.1364/boda.2019.jt4a.51
H. Genish, Matan Binyamin, A. Schwarz, N. Ozana, Z. Zalevsky, R. Califa
A non-contact optical method based on laser speckle contrast analysis in IR for monitoring of blood pulsation is compared to remote PPG. Suggested method show superiority at anatomic sites with week pulsation.
{"title":"Improved Non-contact Optical Monitoring of Blood Pulsation in IR using Laser Speckle Contrast Analysis","authors":"H. Genish, Matan Binyamin, A. Schwarz, N. Ozana, Z. Zalevsky, R. Califa","doi":"10.1364/boda.2019.jt4a.51","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.51","url":null,"abstract":"A non-contact optical method based on laser speckle contrast analysis in IR for monitoring of blood pulsation is compared to remote PPG. Suggested method show superiority at anatomic sites with week pulsation.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84004957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-15DOI: 10.1364/boda.2019.jt4a.8
Laura A. Sordillo, P. Sordillo, Lin Zhang, R. Alfano
There is mounting evidence that there exists a connection between abnormal tryptophan metabolism and neurodegenerative diseases. The relationship between tryptophan and kynurenines in 48 age-matched normal and Alzheimer’s disease human brain tissues was investigated using label-free fluorescence spectroscopy.
{"title":"Tryptophan and kynurenines in neurodegenerative disease","authors":"Laura A. Sordillo, P. Sordillo, Lin Zhang, R. Alfano","doi":"10.1364/boda.2019.jt4a.8","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.8","url":null,"abstract":"There is mounting evidence that there exists a connection between abnormal tryptophan metabolism and neurodegenerative diseases. The relationship between tryptophan and kynurenines in 48 age-matched normal and Alzheimer’s disease human brain tissues was investigated using label-free fluorescence spectroscopy.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76742477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vishnu V. Krishnamurthy, John S. Khamo, P. Mondal, S. Sharum, Jing Yang, Kai Zhang
To decipher the kinetic regulation of growth factor signaling outcomes, I will introduce our recently developed non-neuronal optogenetic strategies that enable reversible control of growth factor signaling during cell differentiation and embryonic development.
{"title":"Reversible Optogenetic Control of Growth Factor Signaling During Cell Differentiation and Vertebrate Embryonic Development","authors":"Vishnu V. Krishnamurthy, John S. Khamo, P. Mondal, S. Sharum, Jing Yang, Kai Zhang","doi":"10.1364/OMA.2019.AW1E.1","DOIUrl":"https://doi.org/10.1364/OMA.2019.AW1E.1","url":null,"abstract":"To decipher the kinetic regulation of growth factor signaling outcomes, I will introduce our recently developed non-neuronal optogenetic strategies that enable reversible control of growth factor signaling during cell differentiation and embryonic development.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76006543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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