Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.21
Jeonghwan Son, B. Mandracchia, Michael D. Caponegro, Styliani-Anna E. Tsirka, Shu Jia
The miniaturized one-photon epi-fluorescence microscopy (miniscopy) has emerged as a powerful tool for in vivo functional brain imaging. Here, we report a computational method to improve the image quality of miniscopy.
{"title":"The gradient and frequency-wise analysis improves wide-field imaging in miniaturized one-photon microscopy","authors":"Jeonghwan Son, B. Mandracchia, Michael D. Caponegro, Styliani-Anna E. Tsirka, Shu Jia","doi":"10.1364/boda.2019.jt4a.21","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.21","url":null,"abstract":"The miniaturized one-photon epi-fluorescence microscopy (miniscopy) has emerged as a powerful tool for in vivo functional brain imaging. Here, we report a computational method to improve the image quality of miniscopy.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90845037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DW2B.4
H. C. Wood, K. Harrington, J. Knight, T. Birks, J. Stone
We describe an imaging fiber bundle that uses 11,000 doped silica cores in an air-filled cladding to image features as small as 3 µm at 1 µm wavelength.
{"title":"High-resolution air-clad imaging fibers","authors":"H. C. Wood, K. Harrington, J. Knight, T. Birks, J. Stone","doi":"10.1364/BODA.2019.DW2B.4","DOIUrl":"https://doi.org/10.1364/BODA.2019.DW2B.4","url":null,"abstract":"We describe an imaging fiber bundle that uses 11,000 doped silica cores in an air-filled cladding to image features as small as 3 µm at 1 µm wavelength.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89292617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.52
Jong Moon Lee, Ibrahim Misbah, Wei-Chuan Shih
Plasmonic arrays fabricated by low-cost nanosphere lithography feature disorderliness and corresponding non-uniform index sensitivity. A calibration technique based on hyperspectral imaging has been implemented to regularize the sensitivity.
{"title":"Regularizing refractive index sensitivity for disordered plasmonic array","authors":"Jong Moon Lee, Ibrahim Misbah, Wei-Chuan Shih","doi":"10.1364/boda.2019.jt4a.52","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.52","url":null,"abstract":"Plasmonic arrays fabricated by low-cost nanosphere lithography feature disorderliness and corresponding non-uniform index sensitivity. A calibration technique based on hyperspectral imaging has been implemented to regularize the sensitivity.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85840589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Using high throughput wide field SH imaging we probe the orientational ordering of water in freestanding lipid membrane hydration shells, and determine real-time membrane potential maps (400 nm, ~100 ms). Applications to neurons are investigated.
{"title":"Label-free dynamic lipid membrane potential imaging","authors":"O. B. Tarun, S. Roke","doi":"10.1364/NTM.2019.NW1C.1","DOIUrl":"https://doi.org/10.1364/NTM.2019.NW1C.1","url":null,"abstract":"Using high throughput wide field SH imaging we probe the orientational ordering of water in freestanding lipid membrane hydration shells, and determine real-time membrane potential maps (400 nm, ~100 ms). Applications to neurons are investigated.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89387663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BRAIN.2019.BM3A.5
Nicolas C. Pégard, L. Waller, H. Adesnik
We synthesize custom light fields by simultaneously modulating light in the spatial and angular domain. Experimental results show new applications for high-resolution 3D displays and for high-speed sculpted illumination with enhanced depth selectivity.
{"title":"Holographic Display and Volumetric Light Sculpting by Dynamic Synthesis of 4d Light Fields","authors":"Nicolas C. Pégard, L. Waller, H. Adesnik","doi":"10.1364/BRAIN.2019.BM3A.5","DOIUrl":"https://doi.org/10.1364/BRAIN.2019.BM3A.5","url":null,"abstract":"We synthesize custom light fields by simultaneously modulating light in the spatial and angular domain. Experimental results show new applications for high-resolution 3D displays and for high-speed sculpted illumination with enhanced depth selectivity.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77050832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.dt3b.7
Alasdair H. Fikouras, M. Schubert, Markus Karl, J. D. Kumar, S. Powis, A. Falco, M. Gather
We report the application of semiconductor nanodisk lasers within living cells. Our lasers have volumes 1000-fold smaller than eukaryotic nuclei, ultralow pulse energy lasing thresholds (Eth≈0.13pJ), and provide excellent spectral stability.
{"title":"Intracellular Semiconductor Nanodisk Lasers","authors":"Alasdair H. Fikouras, M. Schubert, Markus Karl, J. D. Kumar, S. Powis, A. Falco, M. Gather","doi":"10.1364/boda.2019.dt3b.7","DOIUrl":"https://doi.org/10.1364/boda.2019.dt3b.7","url":null,"abstract":"We report the application of semiconductor nanodisk lasers within living cells. Our lasers have volumes 1000-fold smaller than eukaryotic nuclei, ultralow pulse energy lasing thresholds (Eth≈0.13pJ), and provide excellent spectral stability.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"149 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91125570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/brain.2019.bw1a.3
B. Zimmermann, D. Tamborini, J. Selb, A. Martinez, D. Boas
We have developed a low-cost, wearable, and scalable fNIRS system, based on chains of compact and fiber-less electronic optodes, each containing a dual-color LED, photodiode, amplifier, analog to digital converter, and FPGA for demodulation.
{"title":"Development of a Wearable fNIRS System Using Modular Electronic Optodes for Scalability","authors":"B. Zimmermann, D. Tamborini, J. Selb, A. Martinez, D. Boas","doi":"10.1364/brain.2019.bw1a.3","DOIUrl":"https://doi.org/10.1364/brain.2019.bw1a.3","url":null,"abstract":"We have developed a low-cost, wearable, and scalable fNIRS system, based on chains of compact and fiber-less electronic optodes, each containing a dual-color LED, photodiode, amplifier, analog to digital converter, and FPGA for demodulation.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90623075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/brain.2019.bt2a.5
Lisa Beckmann, Xian Zhang, R. Kuranov, N. Nadkarni, Hao F. Zhang
Traditional methods of optical coherence tomography angiography (OCTA) only visualize blood vessels where flow speeds are above a minimum velocity. Here we show that spectral contrast OCTA within the visible-light spectral range can visualize vessels with no flow.
{"title":"Differentiating hemorrhagic and ischemic stroke using spectral contrast optical coherence tomography angiography","authors":"Lisa Beckmann, Xian Zhang, R. Kuranov, N. Nadkarni, Hao F. Zhang","doi":"10.1364/brain.2019.bt2a.5","DOIUrl":"https://doi.org/10.1364/brain.2019.bt2a.5","url":null,"abstract":"Traditional methods of optical coherence tomography angiography (OCTA) only visualize blood vessels where flow speeds are above a minimum velocity. Here we show that spectral contrast OCTA within the visible-light spectral range can visualize vessels with no flow.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88042109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.9
Michael J. Redlich, Hyungsik Lim
We demonstrate label-free intravital imaging of the myelinated fibers in the cerebral cortex of mouse by third-harmonic generation microscopy. Using an optical parametric oscillator as the excitation source, the depth of 250 pm is achieved.
{"title":"Label-Free Intravital Imaging of Cortical Myelin in Mouse Brain by Third-Harmonic Generation Microscopy","authors":"Michael J. Redlich, Hyungsik Lim","doi":"10.1364/boda.2019.jt4a.9","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.9","url":null,"abstract":"We demonstrate label-free intravital imaging of the myelinated fibers in the cerebral cortex of mouse by third-harmonic generation microscopy. Using an optical parametric oscillator as the excitation source, the depth of 250 pm is achieved.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"346 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85450919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DS1A.7
Yu Shimojo, T. Nishimura, H. Hazama, N. Ito, K. Awazu
An in silico method is proposed to evaluate thermal skin damage caused by picosecond laser irradiation. The results show the temperature rise and the thermal damage are noninferiority to a conventional nanosecond domain laser device.
{"title":"In silico Evaluation of Thermal Skin Damage Caused by Picosecond Laser Irradiation","authors":"Yu Shimojo, T. Nishimura, H. Hazama, N. Ito, K. Awazu","doi":"10.1364/BODA.2019.DS1A.7","DOIUrl":"https://doi.org/10.1364/BODA.2019.DS1A.7","url":null,"abstract":"An in silico method is proposed to evaluate thermal skin damage caused by picosecond laser irradiation. The results show the temperature rise and the thermal damage are noninferiority to a conventional nanosecond domain laser device.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86356320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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