Pub Date : 2019-04-14DOI: 10.1364/brain.2019.bt2a.5
Lisa Beckmann, Xian Zhang, R. Kuranov, N. Nadkarni, Hao F. Zhang
Traditional methods of optical coherence tomography angiography (OCTA) only visualize blood vessels where flow speeds are above a minimum velocity. Here we show that spectral contrast OCTA within the visible-light spectral range can visualize vessels with no flow.
{"title":"Differentiating hemorrhagic and ischemic stroke using spectral contrast optical coherence tomography angiography","authors":"Lisa Beckmann, Xian Zhang, R. Kuranov, N. Nadkarni, Hao F. Zhang","doi":"10.1364/brain.2019.bt2a.5","DOIUrl":"https://doi.org/10.1364/brain.2019.bt2a.5","url":null,"abstract":"Traditional methods of optical coherence tomography angiography (OCTA) only visualize blood vessels where flow speeds are above a minimum velocity. Here we show that spectral contrast OCTA within the visible-light spectral range can visualize vessels with no flow.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88042109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DS1A.7
Yu Shimojo, T. Nishimura, H. Hazama, N. Ito, K. Awazu
An in silico method is proposed to evaluate thermal skin damage caused by picosecond laser irradiation. The results show the temperature rise and the thermal damage are noninferiority to a conventional nanosecond domain laser device.
{"title":"In silico Evaluation of Thermal Skin Damage Caused by Picosecond Laser Irradiation","authors":"Yu Shimojo, T. Nishimura, H. Hazama, N. Ito, K. Awazu","doi":"10.1364/BODA.2019.DS1A.7","DOIUrl":"https://doi.org/10.1364/BODA.2019.DS1A.7","url":null,"abstract":"An in silico method is proposed to evaluate thermal skin damage caused by picosecond laser irradiation. The results show the temperature rise and the thermal damage are noninferiority to a conventional nanosecond domain laser device.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86356320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/brain.2019.bw1a.3
B. Zimmermann, D. Tamborini, J. Selb, A. Martinez, D. Boas
We have developed a low-cost, wearable, and scalable fNIRS system, based on chains of compact and fiber-less electronic optodes, each containing a dual-color LED, photodiode, amplifier, analog to digital converter, and FPGA for demodulation.
{"title":"Development of a Wearable fNIRS System Using Modular Electronic Optodes for Scalability","authors":"B. Zimmermann, D. Tamborini, J. Selb, A. Martinez, D. Boas","doi":"10.1364/brain.2019.bw1a.3","DOIUrl":"https://doi.org/10.1364/brain.2019.bw1a.3","url":null,"abstract":"We have developed a low-cost, wearable, and scalable fNIRS system, based on chains of compact and fiber-less electronic optodes, each containing a dual-color LED, photodiode, amplifier, analog to digital converter, and FPGA for demodulation.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90623075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.48
Chih-Chiang Chang, Yichen Ding, K. Baek, Xili Ding, Dong Wang, Song Li, R. Packard, T. Hsiai
Light-sheet fluorescence microscopy (LSFM) coupled with fluorescence-friendly tissue clearing technique enables the detailed analysis of 3-D vascular network in the murine retina.
光片荧光显微镜(LSFM)与荧光友好的组织清除技术相结合，可以详细分析小鼠视网膜中的三维血管网络。
{"title":"Light-sheet Imaging to Characterize Vascular Development in Murine Retina","authors":"Chih-Chiang Chang, Yichen Ding, K. Baek, Xili Ding, Dong Wang, Song Li, R. Packard, T. Hsiai","doi":"10.1364/boda.2019.jt4a.48","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.48","url":null,"abstract":"Light-sheet fluorescence microscopy (LSFM) coupled with fluorescence-friendly tissue clearing technique enables the detailed analysis of 3-D vascular network in the murine retina.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75979035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Liu, Vaishnavi Madhavan, N. Antipa, Grace Kuo, Saul Kato, L. Waller
We propose a single-shot 3D fluorescence microscope that achieves large field-of-view and good resolution across a wide axial range. This is implemented by inserting a diffuser into the Fourier plane of the objective and solving an inverse problem. We show experimental 3D results of a freely-moving C. elegans nematode at 25 fps.
{"title":"Single-shot 3D fluorescence microscopy with Fourier DiffuserCam","authors":"F. Liu, Vaishnavi Madhavan, N. Antipa, Grace Kuo, Saul Kato, L. Waller","doi":"10.1364/NTM.2019.NS2B.3","DOIUrl":"https://doi.org/10.1364/NTM.2019.NS2B.3","url":null,"abstract":"We propose a single-shot 3D fluorescence microscope that achieves large field-of-view and good resolution across a wide axial range. This is implemented by inserting a diffuser into the Fourier plane of the objective and solving an inverse problem. We show experimental 3D results of a freely-moving C. elegans nematode at 25 fps.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78405512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.9
Michael J. Redlich, Hyungsik Lim
We demonstrate label-free intravital imaging of the myelinated fibers in the cerebral cortex of mouse by third-harmonic generation microscopy. Using an optical parametric oscillator as the excitation source, the depth of 250 pm is achieved.
{"title":"Label-Free Intravital Imaging of Cortical Myelin in Mouse Brain by Third-Harmonic Generation Microscopy","authors":"Michael J. Redlich, Hyungsik Lim","doi":"10.1364/boda.2019.jt4a.9","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.9","url":null,"abstract":"We demonstrate label-free intravital imaging of the myelinated fibers in the cerebral cortex of mouse by third-harmonic generation microscopy. Using an optical parametric oscillator as the excitation source, the depth of 250 pm is achieved.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"346 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85450919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.49
S. Gastélum-Acuña, A. Ramírez-Duverger, R. García-Llamas
We propose a metallic hybrid system in contact with biological fluid to study optically the fluid by using surface plasmon polariton spectroscopy. A thin film of Ag and other of Al forms the bimetallic layer.
{"title":"Surface plasmon polariton excitation in a metallic hybrid film for optical studies of a biological fluid","authors":"S. Gastélum-Acuña, A. Ramírez-Duverger, R. García-Llamas","doi":"10.1364/boda.2019.jt4a.49","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.49","url":null,"abstract":"We propose a metallic hybrid system in contact with biological fluid to study optically the fluid by using surface plasmon polariton spectroscopy. A thin film of Ag and other of Al forms the bimetallic layer.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88621289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DW1B.3
Suyan Qiu, Wei-Chuan Shih
Sensitive and selective detection and quantitation of small molecules and enzymatic activities have been attempted using surface-enhanced Raman spectroscopy (SERS). Pre-immobilized aptamers and in situ assembled aptamer have been developed.
{"title":"Aptamer-based SERS detection and quantitation of small molecules and enzymes on plasmonic nanostructures","authors":"Suyan Qiu, Wei-Chuan Shih","doi":"10.1364/BODA.2019.DW1B.3","DOIUrl":"https://doi.org/10.1364/BODA.2019.DW1B.3","url":null,"abstract":"Sensitive and selective detection and quantitation of small molecules and enzymatic activities have been attempted using surface-enhanced Raman spectroscopy (SERS). Pre-immobilized aptamers and in situ assembled aptamer have been developed.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91515305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.36
Emaan Alsubhe, A. Anastasiou, C. Maddi, Mostafa El-Raif, P. Giannoudis, A. Jha
In this work, we aim to investigate the effect of Fe2+/Fe3+ doping on the laser sintering of calcium phosphate minerals for the fabrication of bone scaffolds. The laser-matter mechanisms and the biological response are discussed.
{"title":"Interaction of Femtosecond Pulsed Lasers with Fe2+ and Fe3+ Doped Calcium Phosphates for Bone Tissue Engineering","authors":"Emaan Alsubhe, A. Anastasiou, C. Maddi, Mostafa El-Raif, P. Giannoudis, A. Jha","doi":"10.1364/boda.2019.jt4a.36","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.36","url":null,"abstract":"In this work, we aim to investigate the effect of Fe2+/Fe3+ doping on the laser sintering of calcium phosphate minerals for the fabrication of bone scaffolds. The laser-matter mechanisms and the biological response are discussed.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90705676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
You Zhou, Guoxun Zhang, Jiamin Wu, Myunghwan Choi, Qionghai Dai
We propose a wavefront shaping method to improve the spatial resolution and light collection efficiency of a GRIN-lens-based endoscopic system. The genetic algorithm and a real-time feedback strategy are used for the search of an optimized phase modulation pattern.
{"title":"Wavefront shaping for achieving high NA GRIN-lens-based endoscopic imaging","authors":"You Zhou, Guoxun Zhang, Jiamin Wu, Myunghwan Choi, Qionghai Dai","doi":"10.1364/ntm.2019.nt2c.4","DOIUrl":"https://doi.org/10.1364/ntm.2019.nt2c.4","url":null,"abstract":"We propose a wavefront shaping method to improve the spatial resolution and light collection efficiency of a GRIN-lens-based endoscopic system. The genetic algorithm and a real-time feedback strategy are used for the search of an optimized phase modulation pattern.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"141 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76727423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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