Pub Date : 2019-04-14DOI: 10.1364/boda.2019.dt2b.3
P. Stremplewski, E. Auksorius, P. Wnuk, Łukasz Kozoń, P. Garstecki, M. Wojtkowski
We report on a system that is able to significantly reduce cross-talk and speckle noise in Fourier domain full-field optical coherence tomography. It is achieved by fast phase modulation of a laser wavefront and angular compounding.
{"title":"Speckle-free and cross-talk-free imaging in Fourier domain full-field optical coherence tomography","authors":"P. Stremplewski, E. Auksorius, P. Wnuk, Łukasz Kozoń, P. Garstecki, M. Wojtkowski","doi":"10.1364/boda.2019.dt2b.3","DOIUrl":"https://doi.org/10.1364/boda.2019.dt2b.3","url":null,"abstract":"We report on a system that is able to significantly reduce cross-talk and speckle noise in Fourier domain full-field optical coherence tomography. It is achieved by fast phase modulation of a laser wavefront and angular compounding.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82462121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.50
J. Bogusławski, Natalia Pacocha, Michał Horka, M. Wojtkowski, P. Garstecki
A microfluidic platform for an optical, label-free screening of bacteria growth in nanoliter droplets is demonstrated. We show that based on droplet’s scattering properties we can perform a reliable binary readout.
{"title":"Optofluidic Platform for Bacteria Screening in Nanoliter Droplets","authors":"J. Bogusławski, Natalia Pacocha, Michał Horka, M. Wojtkowski, P. Garstecki","doi":"10.1364/boda.2019.jt4a.50","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.50","url":null,"abstract":"A microfluidic platform for an optical, label-free screening of bacteria growth in nanoliter droplets is demonstrated. We show that based on droplet’s scattering properties we can perform a reliable binary readout.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81578956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DW1B.3
Suyan Qiu, Wei-Chuan Shih
Sensitive and selective detection and quantitation of small molecules and enzymatic activities have been attempted using surface-enhanced Raman spectroscopy (SERS). Pre-immobilized aptamers and in situ assembled aptamer have been developed.
{"title":"Aptamer-based SERS detection and quantitation of small molecules and enzymes on plasmonic nanostructures","authors":"Suyan Qiu, Wei-Chuan Shih","doi":"10.1364/BODA.2019.DW1B.3","DOIUrl":"https://doi.org/10.1364/BODA.2019.DW1B.3","url":null,"abstract":"Sensitive and selective detection and quantitation of small molecules and enzymatic activities have been attempted using surface-enhanced Raman spectroscopy (SERS). Pre-immobilized aptamers and in situ assembled aptamer have been developed.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91515305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Liu, Vaishnavi Madhavan, N. Antipa, Grace Kuo, Saul Kato, L. Waller
We propose a single-shot 3D fluorescence microscope that achieves large field-of-view and good resolution across a wide axial range. This is implemented by inserting a diffuser into the Fourier plane of the objective and solving an inverse problem. We show experimental 3D results of a freely-moving C. elegans nematode at 25 fps.
{"title":"Single-shot 3D fluorescence microscopy with Fourier DiffuserCam","authors":"F. Liu, Vaishnavi Madhavan, N. Antipa, Grace Kuo, Saul Kato, L. Waller","doi":"10.1364/NTM.2019.NS2B.3","DOIUrl":"https://doi.org/10.1364/NTM.2019.NS2B.3","url":null,"abstract":"We propose a single-shot 3D fluorescence microscope that achieves large field-of-view and good resolution across a wide axial range. This is implemented by inserting a diffuser into the Fourier plane of the objective and solving an inverse problem. We show experimental 3D results of a freely-moving C. elegans nematode at 25 fps.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78405512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.48
Chih-Chiang Chang, Yichen Ding, K. Baek, Xili Ding, Dong Wang, Song Li, R. Packard, T. Hsiai
Light-sheet fluorescence microscopy (LSFM) coupled with fluorescence-friendly tissue clearing technique enables the detailed analysis of 3-D vascular network in the murine retina.
光片荧光显微镜(LSFM)与荧光友好的组织清除技术相结合，可以详细分析小鼠视网膜中的三维血管网络。
{"title":"Light-sheet Imaging to Characterize Vascular Development in Murine Retina","authors":"Chih-Chiang Chang, Yichen Ding, K. Baek, Xili Ding, Dong Wang, Song Li, R. Packard, T. Hsiai","doi":"10.1364/boda.2019.jt4a.48","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.48","url":null,"abstract":"Light-sheet fluorescence microscopy (LSFM) coupled with fluorescence-friendly tissue clearing technique enables the detailed analysis of 3-D vascular network in the murine retina.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75979035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.JT4A.22
Julie Bouhy, Angel Martin Fernandez Alvarez, Catherine Charles, O. Deparis
We adapted a polarizing microscopy technique involving image processing in order to determine birefringence patterns in anisotropic biological tissues. The methodology is applied to the study of parchments’ material degradation and internal strains.
{"title":"Adapted polarizing microscopy technique for the determination of birefringence patterns in parchments","authors":"Julie Bouhy, Angel Martin Fernandez Alvarez, Catherine Charles, O. Deparis","doi":"10.1364/BODA.2019.JT4A.22","DOIUrl":"https://doi.org/10.1364/BODA.2019.JT4A.22","url":null,"abstract":"We adapted a polarizing microscopy technique involving image processing in order to determine birefringence patterns in anisotropic biological tissues. The methodology is applied to the study of parchments’ material degradation and internal strains.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77634131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/BODA.2019.DM3B.3
Hao F. Zhang, Brian T. Soetikno, Lisa Beckmann, Xian Zhang, Ian Rubinoff, R. Kuranov
We developed a combined cross-correlation and graph-search segmentation techniques, to reliably extract the backscattered light spectrum so that we can improve the accuracy of retinal oximetry using visible-light OCT.
{"title":"Improving accuracy of visible-light OCT oximetry in rodents and humans","authors":"Hao F. Zhang, Brian T. Soetikno, Lisa Beckmann, Xian Zhang, Ian Rubinoff, R. Kuranov","doi":"10.1364/BODA.2019.DM3B.3","DOIUrl":"https://doi.org/10.1364/BODA.2019.DM3B.3","url":null,"abstract":"We developed a combined cross-correlation and graph-search segmentation techniques, to reliably extract the backscattered light spectrum so that we can improve the accuracy of retinal oximetry using visible-light OCT.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74090601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.49
S. Gastélum-Acuña, A. Ramírez-Duverger, R. García-Llamas
We propose a metallic hybrid system in contact with biological fluid to study optically the fluid by using surface plasmon polariton spectroscopy. A thin film of Ag and other of Al forms the bimetallic layer.
{"title":"Surface plasmon polariton excitation in a metallic hybrid film for optical studies of a biological fluid","authors":"S. Gastélum-Acuña, A. Ramírez-Duverger, R. García-Llamas","doi":"10.1364/boda.2019.jt4a.49","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.49","url":null,"abstract":"We propose a metallic hybrid system in contact with biological fluid to study optically the fluid by using surface plasmon polariton spectroscopy. A thin film of Ag and other of Al forms the bimetallic layer.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88621289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.1364/boda.2019.jt4a.36
Emaan Alsubhe, A. Anastasiou, C. Maddi, Mostafa El-Raif, P. Giannoudis, A. Jha
In this work, we aim to investigate the effect of Fe2+/Fe3+ doping on the laser sintering of calcium phosphate minerals for the fabrication of bone scaffolds. The laser-matter mechanisms and the biological response are discussed.
{"title":"Interaction of Femtosecond Pulsed Lasers with Fe2+ and Fe3+ Doped Calcium Phosphates for Bone Tissue Engineering","authors":"Emaan Alsubhe, A. Anastasiou, C. Maddi, Mostafa El-Raif, P. Giannoudis, A. Jha","doi":"10.1364/boda.2019.jt4a.36","DOIUrl":"https://doi.org/10.1364/boda.2019.jt4a.36","url":null,"abstract":"In this work, we aim to investigate the effect of Fe2+/Fe3+ doping on the laser sintering of calcium phosphate minerals for the fabrication of bone scaffolds. The laser-matter mechanisms and the biological response are discussed.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90705676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
You Zhou, Guoxun Zhang, Jiamin Wu, Myunghwan Choi, Qionghai Dai
We propose a wavefront shaping method to improve the spatial resolution and light collection efficiency of a GRIN-lens-based endoscopic system. The genetic algorithm and a real-time feedback strategy are used for the search of an optimized phase modulation pattern.
{"title":"Wavefront shaping for achieving high NA GRIN-lens-based endoscopic imaging","authors":"You Zhou, Guoxun Zhang, Jiamin Wu, Myunghwan Choi, Qionghai Dai","doi":"10.1364/ntm.2019.nt2c.4","DOIUrl":"https://doi.org/10.1364/ntm.2019.nt2c.4","url":null,"abstract":"We propose a wavefront shaping method to improve the spatial resolution and light collection efficiency of a GRIN-lens-based endoscopic system. The genetic algorithm and a real-time feedback strategy are used for the search of an optimized phase modulation pattern.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76727423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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