{"title":"Evolving profiles and treatment success predictors among tuberculosis patients in Uganda from 2019 to 2023: a registry based study.","authors":"Collins Ankunda, Jude Emunyu, Sharon Namasambi, Conrad Sserunjogi, Brendah Kyomuhangi, Iving Mumbere, Jane Nakawesi","doi":"10.1186/s12879-026-12887-6","DOIUrl":"https://doi.org/10.1186/s12879-026-12887-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12764-2
Heloi Stefani, Daniel Hanawa Morisaki, Boanerge Ojeda Ch, Madhu Babu Adusumilli, Angel Lorenzo Porras, Maha Albukhari, Folusakin Ayoade
Deep tissue and bloodstream yeast infections are associated with poor outcomes due to rapid progression, antifungal resistance, and immune evasion. Differentiating between wound contamination and true fungal infection remains a clinical challenge, with limited guidance on the use of prophylactic antifungal therapy in this setting. This article presents a rare case of an immunocompetent patient who sustained a degloving hand injury and radius fracture from a bread kneading machine, with subsequent deep tissue cultures growing Saccharomyces cerevisiae. The case underscores the potential risk of fungal infection in occupational injuries involving dough and emphasizes the importance of early identification and consideration of prophylactic antifungal treatment in similar scenarios.
{"title":"Saccharomyces cerevisiae isolated in a degloving baker's machine injury, a contamination or infection - a case report.","authors":"Heloi Stefani, Daniel Hanawa Morisaki, Boanerge Ojeda Ch, Madhu Babu Adusumilli, Angel Lorenzo Porras, Maha Albukhari, Folusakin Ayoade","doi":"10.1186/s12879-026-12764-2","DOIUrl":"https://doi.org/10.1186/s12879-026-12764-2","url":null,"abstract":"<p><p>Deep tissue and bloodstream yeast infections are associated with poor outcomes due to rapid progression, antifungal resistance, and immune evasion. Differentiating between wound contamination and true fungal infection remains a clinical challenge, with limited guidance on the use of prophylactic antifungal therapy in this setting. This article presents a rare case of an immunocompetent patient who sustained a degloving hand injury and radius fracture from a bread kneading machine, with subsequent deep tissue cultures growing Saccharomyces cerevisiae. The case underscores the potential risk of fungal infection in occupational injuries involving dough and emphasizes the importance of early identification and consideration of prophylactic antifungal treatment in similar scenarios.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12895-6
Mark Okwir, Emmy Okello, Abigail Link, Immaculate Akullo, Pancras Odongo, Bernard Omech, Francis Kiweewa, Yu Liu, David Meya, Paul R Bohjanen, Robert C Block
{"title":"Major adverse cardiovascular events, morbidity, and mortality, among people living with and without HIV in two northern Uganda hospitals.","authors":"Mark Okwir, Emmy Okello, Abigail Link, Immaculate Akullo, Pancras Odongo, Bernard Omech, Francis Kiweewa, Yu Liu, David Meya, Paul R Bohjanen, Robert C Block","doi":"10.1186/s12879-026-12895-6","DOIUrl":"https://doi.org/10.1186/s12879-026-12895-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of concomitant pill burden with antiretroviral adherence and persistence: retrospective analysis of a Japanese claims database.","authors":"Nao Taguchi, Yi Piao, Soodi Navadeh, Kuan-Yeh Lee, Keisuke Harada, Jesse Najarro Cermeño, Toshio Naito","doi":"10.1186/s12879-026-12844-3","DOIUrl":"https://doi.org/10.1186/s12879-026-12844-3","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12860-3
Weijie Zhou, Xiaodi Zou, Jiaqi Li, Ahmad Alhaskawi, Sahar Ahmed Abdalbary, Hui Lu
Background: Osteomyelitis of the hand is relatively uncommon and often results from penetrating trauma or postoperative infection. Rare pathogens such as Actinomyces radingae and Finegoldia magna pose diagnostic and therapeutic challenges due to their slow growth, frequent involvement in polymicrobial infections, and limited antibiotic susceptibility data.
Case presentation: A 66-year-old male sustained a crush injury being caught in a door to his right thumb over two years prior, leading to repeated episodes of redness, swelling, pain, and restricted motion. Despite undergoing surgical intervention three months earlier at another hospital, his symptoms persisted. Radiography revealed cortical irregularity and surrounding soft tissue swelling of the distal phalanx. Magnetic resonance imaging revealed bone marrow edema of the distal phalanx and adjacent soft tissue inflammation, raising suspicion for underlying osteomyelitis in the appropriate clinical context. Laboratory markers of infection were within normal limits. The patient underwent surgery including necrotic bone removal, extensor tendon reconstruction with muscle transposition, and nail bed debridement. Intraoperative findings included purulent drainage, nail deformity, and tendon necrosis. Metagenomic next-generation sequencing (mNGS)of bone tissue identified Actinomyces radingae (8,019 reads) and Finegoldia magna (4,223 reads). Based on the chronic clinical course, imaging findings, intraoperative evidence of necrotic bone, and pathogen identification by metagenomic next-generation sequencing, a diagnosis of chronic osteomyelitis of the distal phalanx was established. Postoperatively, the patient received ertapenem (1 g QD) with good clinical response.
Conclusion: This case highlights the importance of considering uncommon pathogens in chronic post-traumatic hand infections and demonstrates the utility of mNGS in identifying atypical bacteria, enabling targeted therapy and improved outcomes.
背景：手部骨髓炎相对罕见，通常由穿透性创伤或术后感染引起。放射状放线菌和大细粒细粒放线菌等罕见病原体由于生长缓慢，经常参与多微生物感染，以及有限的抗生素敏感性数据，给诊断和治疗带来了挑战。病例介绍：一名66岁男性，两年前因右手拇指被门夹住而挤压伤，导致反复发红、肿胀、疼痛和活动受限。尽管三个月前在另一家医院接受了手术干预，但他的症状仍然存在。x线摄影显示皮质不规则及远端指骨周围软组织肿胀。磁共振成像显示远端指骨骨髓水肿和邻近软组织炎症，在适当的临床背景下怀疑潜在的骨髓炎。实验室感染指标在正常范围内。患者接受了手术，包括坏死骨去除，伸肌腱重建和肌肉转位，以及甲床清创。术中发现化脓性引流，指甲畸形，肌腱坏死。骨组织的新一代宏基因组测序（mNGS）鉴定出放线菌radingae（8,019个reads）和Finegoldia magna（4,223个reads）。根据慢性临床病程、影像学表现、术中坏死骨的证据以及新一代宏基因组测序鉴定的病原体，诊断为远端指骨慢性骨髓炎。术后给予厄他培南（1 g QD）治疗，临床反应良好。结论：该病例强调了在慢性创伤后手部感染中考虑罕见病原体的重要性，并证明了mNGS在识别非典型细菌，实现靶向治疗和改善预后方面的作用。
{"title":"Chronic osteomyelitis of the right thumb caused by Actinomyces radingae and Finegoldia magna: a case report and literature review.","authors":"Weijie Zhou, Xiaodi Zou, Jiaqi Li, Ahmad Alhaskawi, Sahar Ahmed Abdalbary, Hui Lu","doi":"10.1186/s12879-026-12860-3","DOIUrl":"https://doi.org/10.1186/s12879-026-12860-3","url":null,"abstract":"<p><strong>Background: </strong>Osteomyelitis of the hand is relatively uncommon and often results from penetrating trauma or postoperative infection. Rare pathogens such as Actinomyces radingae and Finegoldia magna pose diagnostic and therapeutic challenges due to their slow growth, frequent involvement in polymicrobial infections, and limited antibiotic susceptibility data.</p><p><strong>Case presentation: </strong>A 66-year-old male sustained a crush injury being caught in a door to his right thumb over two years prior, leading to repeated episodes of redness, swelling, pain, and restricted motion. Despite undergoing surgical intervention three months earlier at another hospital, his symptoms persisted. Radiography revealed cortical irregularity and surrounding soft tissue swelling of the distal phalanx. Magnetic resonance imaging revealed bone marrow edema of the distal phalanx and adjacent soft tissue inflammation, raising suspicion for underlying osteomyelitis in the appropriate clinical context. Laboratory markers of infection were within normal limits. The patient underwent surgery including necrotic bone removal, extensor tendon reconstruction with muscle transposition, and nail bed debridement. Intraoperative findings included purulent drainage, nail deformity, and tendon necrosis. Metagenomic next-generation sequencing (mNGS)of bone tissue identified Actinomyces radingae (8,019 reads) and Finegoldia magna (4,223 reads). Based on the chronic clinical course, imaging findings, intraoperative evidence of necrotic bone, and pathogen identification by metagenomic next-generation sequencing, a diagnosis of chronic osteomyelitis of the distal phalanx was established. Postoperatively, the patient received ertapenem (1 g QD) with good clinical response.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering uncommon pathogens in chronic post-traumatic hand infections and demonstrates the utility of mNGS in identifying atypical bacteria, enabling targeted therapy and improved outcomes.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12832-7
Hyasinta Jaka, Semvua B Kilonzo, Igembe Nkandala, Ladius Rudovick, Irun Luchius, Violet Dismas Kajogoo, Violet Kayamba, Mathias Mlewa, Peter Kibunto, Anthony Liwa, Musa Ian Joel, Mariam M Mirambo, Stephen E Mshana
{"title":"Prevalence, risk factors, and endoscopic findings among individuals infected with Helicobacter pylori in Tanzania: A systematic review and meta-analysis.","authors":"Hyasinta Jaka, Semvua B Kilonzo, Igembe Nkandala, Ladius Rudovick, Irun Luchius, Violet Dismas Kajogoo, Violet Kayamba, Mathias Mlewa, Peter Kibunto, Anthony Liwa, Musa Ian Joel, Mariam M Mirambo, Stephen E Mshana","doi":"10.1186/s12879-026-12832-7","DOIUrl":"https://doi.org/10.1186/s12879-026-12832-7","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12864-z
Michaela Krivošová, Peter Kunč, Jaroslav Fábry, Juraj Mokrý, Matúš Dohál
{"title":"Alterations and predictive potential of haematological parameters in paediatric tuberculosis and non-tuberculous mycobacterial disease.","authors":"Michaela Krivošová, Peter Kunč, Jaroslav Fábry, Juraj Mokrý, Matúš Dohál","doi":"10.1186/s12879-026-12864-z","DOIUrl":"https://doi.org/10.1186/s12879-026-12864-z","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-026-12884-9
Henry Kwadwo Hackman, Alice Constance Mensah, Lawrence Annison, Reuben Essel Arhin, Ebenezer Krampah Aidoo, George Osei-Adjei, Nelson Addo, Augustine E Sagoe, Fiifi Appiah-Mends
{"title":"Treatment outcomes among tuberculosis patients with co-morbidities at Ghana's premier national referral centre: a retrospective cross-sectional study.","authors":"Henry Kwadwo Hackman, Alice Constance Mensah, Lawrence Annison, Reuben Essel Arhin, Ebenezer Krampah Aidoo, George Osei-Adjei, Nelson Addo, Augustine E Sagoe, Fiifi Appiah-Mends","doi":"10.1186/s12879-026-12884-9","DOIUrl":"https://doi.org/10.1186/s12879-026-12884-9","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s12879-025-12507-9
Agbata Benedict Celestine, Mehmet Gümüş, A K Awasthi, Homan Emadifar, Aseel Smerat, Bolarinwa Bolaji
{"title":"The impact of treatment accessibility on HIV-TB co-infection: a comparative fractional-order modeling approach.","authors":"Agbata Benedict Celestine, Mehmet Gümüş, A K Awasthi, Homan Emadifar, Aseel Smerat, Bolarinwa Bolaji","doi":"10.1186/s12879-025-12507-9","DOIUrl":"https://doi.org/10.1186/s12879-025-12507-9","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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