Chrystal Chang, David W. Barham, Zafardjan Dalimov, Daniel Swerdloff, Hossein Sadeghi‐Nejad, Robert Andrianne, Maxime Sempels, Tung‐Chin Hsieh, Georgios Hatzichristodoulou, Muhammed Hammad, Jake Miller, Daniar Osmonov, Aaron Lentz, Paul Perito, Alfredo Suarez‐Sarmiento, James Hotaling, Kelli Gross, James M Jones, Koenraad van Renterghem, Sung Hun Park, Jonathan N. Warner, Matthew Ziegelmann, Vaibhav Modgil, Adam Jones, Ian Pearce, Arthur L. Burnett, Martin S. Gross, Faysal A. Yafi, Jay Simhan
ObjectivesTo evaluate the pre‐ and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.Patients and MethodsWe retrospectively reviewed a 16‐centre multi‐institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra‐ and postoperative corporal complications.ResultsWe identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15–12.92; P < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32–3.39; P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18–2.77; P = 0.006), older age (OR 1.02, 95% CI 1.01–1.04; P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0–2.5; P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18–12.88; P < 0.001), corporal scarring (OR 2.77, 95% CI 1.64–4.69; P < 0.001), radiation therapy (OR 2.25, 95% CI 1.0–5.04; P = 0.049), and older age (OR 1.03, 95% CI 1.0–1.05; P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69–17.01; P < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61–7.19; P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56–5.72; P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08–11.99; P = 0.038) were predictive of pPCI.ConclusionCoronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient‐specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer‐term device viability.
目的评估充气阴茎假体（IPP）置入后影响体体完整性的术前和术中变量，因为术中体体穿孔和延迟性假体并发症的预测因素尚未得到很好的表征。患者和方法我们回顾性地回顾了2016年至2021年由经验丰富的种植者进行的IPP手术的16个中心多机构数据库。下体完整性差（PCI）定义为术中（iPCI）下体并发症或术后（pPCI）下体并发症。进行多变量分析以确定PCI、iPCI和pPCI的独立预测因子。主要结局包括体内和术后的身体并发症。结果从5406例IPP患者中筛选出5153例进行分析，其中152例（2.95%）行PCI。在多变量分析中，PCI的预测因素包括改良IPP手术(优势比[OR] 8.16, 95%可信区间[CI] 5.15-12.92；P & lt;0.001)，序贯扩张(OR 2.12, 95% CI 1.32-3.39；P = 0.002)，冠状动脉疾病(CAD)/外周血管疾病（PVD） (OR 1.81, 95% CI 1.18-2.77；P = 0.006)，年龄较大(OR 1.02, 95% CI 1.01-1.04；P = 0.013)和体表疤痕(OR 1.58, 95% CI 1.0-2.5；P = 0.049)。iPCI的预测因素包括改良IPP手术(OR 7.34, 95% CI 4.18-12.88；P & lt;0.001)，体表疤痕(OR 2.77, 95% CI 1.64-4.69；P & lt;0.001)，放射治疗(OR 2.25, 95% CI 1.0-5.04；P = 0.049)，年龄越大(OR 1.03, 95% CI 1.0-1.05；P = 0.025)。改良IPP手术(OR 7.92, 95% CI 3.69-17.01；P & lt;0.001)，序贯扩张(OR 3.4, 95% CI 1.61-7.19；P = 0.001), cad / pvd (or 2.98, 95% ci 1.56-5.72；P = 0.001)，以及阴茎勃起史(OR 3.59, 95% CI 1.08-11.99；P = 0.038)预测pPCI。结论冠状动脉疾病/PVD、年龄较大、有体瘢痕、接受IPP翻修手术和序贯扩张是PCI相关并发症的预测危险因素。识别有PCI风险的患者可以改善患者特异性咨询，考虑转诊给更有经验的植入者，并制定手术计划，以潜在地提高设备的长期生存能力。
{"title":"New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation","authors":"Chrystal Chang, David W. Barham, Zafardjan Dalimov, Daniel Swerdloff, Hossein Sadeghi‐Nejad, Robert Andrianne, Maxime Sempels, Tung‐Chin Hsieh, Georgios Hatzichristodoulou, Muhammed Hammad, Jake Miller, Daniar Osmonov, Aaron Lentz, Paul Perito, Alfredo Suarez‐Sarmiento, James Hotaling, Kelli Gross, James M Jones, Koenraad van Renterghem, Sung Hun Park, Jonathan N. Warner, Matthew Ziegelmann, Vaibhav Modgil, Adam Jones, Ian Pearce, Arthur L. Burnett, Martin S. Gross, Faysal A. Yafi, Jay Simhan","doi":"10.1111/bju.16607","DOIUrl":"https://doi.org/10.1111/bju.16607","url":null,"abstract":"ObjectivesTo evaluate the pre‐ and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.Patients and MethodsWe retrospectively reviewed a 16‐centre multi‐institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra‐ and postoperative corporal complications.ResultsWe identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15–12.92; <jats:italic>P</jats:italic> < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32–3.39; <jats:italic>P</jats:italic> = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18–2.77; <jats:italic>P</jats:italic> = 0.006), older age (OR 1.02, 95% CI 1.01–1.04; <jats:italic>P</jats:italic> = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0–2.5; <jats:italic>P</jats:italic> = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18–12.88; <jats:italic>P</jats:italic> < 0.001), corporal scarring (OR 2.77, 95% CI 1.64–4.69; <jats:italic>P</jats:italic> < 0.001), radiation therapy (OR 2.25, 95% CI 1.0–5.04; <jats:italic>P</jats:italic> = 0.049), and older age (OR 1.03, 95% CI 1.0–1.05; <jats:italic>P</jats:italic> = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69–17.01; <jats:italic>P</jats:italic> < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61–7.19; <jats:italic>P</jats:italic> = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56–5.72; <jats:italic>P</jats:italic> = 0.001), and history of priapism (OR 3.59, 95% CI 1.08–11.99; <jats:italic>P</jats:italic> = 0.038) were predictive of pPCI.ConclusionCoronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient‐specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer‐term device viability.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"236 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhruv Puri, Margaret F. Meagher, Zhenjie Wu, Antonio Franco, Linhui Wang, Vitaly Margulis, Raj Bhanvadia, Firas Abdollah, Marco Finati, Alessandro Antonelli, Francesco Ditonno, Nirmish Singla, Stephan Broenimann, Giuseppe Simone, Gabriele Tuderti, Soroush Rais-Bahrami, Sol C. Moon, Matteo Ferro, Marco Tozzi, Francesco Porpiglia, Daniele Amparore, Andreas Correa, Emma Helstrom, Mark L. Gonzalgo, Dinno F. Mendiola, Sisto Perdonà, Antonio Tufano, Benjamine M. Eilender, Reza Mehrazin, Courtney Yong, Alireza Ghoreifi, Chandru P. Sundaram, Hooman Djaladat, Riccardo Autorino, Ithaar H. Derweesh
To investigate the prevalence, predictors and impact of surgically induced chronic kidney disease (CKD-S) on survival outcomes in patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).
{"title":"The impact of post-nephroureterectomy surgically induced chronic kidney disease on survival outcomes","authors":"Dhruv Puri, Margaret F. Meagher, Zhenjie Wu, Antonio Franco, Linhui Wang, Vitaly Margulis, Raj Bhanvadia, Firas Abdollah, Marco Finati, Alessandro Antonelli, Francesco Ditonno, Nirmish Singla, Stephan Broenimann, Giuseppe Simone, Gabriele Tuderti, Soroush Rais-Bahrami, Sol C. Moon, Matteo Ferro, Marco Tozzi, Francesco Porpiglia, Daniele Amparore, Andreas Correa, Emma Helstrom, Mark L. Gonzalgo, Dinno F. Mendiola, Sisto Perdonà, Antonio Tufano, Benjamine M. Eilender, Reza Mehrazin, Courtney Yong, Alireza Ghoreifi, Chandru P. Sundaram, Hooman Djaladat, Riccardo Autorino, Ithaar H. Derweesh","doi":"10.1111/bju.16569","DOIUrl":"https://doi.org/10.1111/bju.16569","url":null,"abstract":"To investigate the prevalence, predictors and impact of surgically induced chronic kidney disease (CKD-S) on survival outcomes in patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"141 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Antonelli, Axel Heidenreich, Aditya Bagrodia, Armon Amini, Fady Baky, Nicolas Branger, Walter Cazzaniga, Timothy N. Clinton, Siamak Daneshmand, Hooman Djaladat, Scott Eggener, Alireza Ghoreifi, Robert J. Hamilton, Matthew Ho, Wade J. Sexton, Sebastiano Nazzani, David Nicol, Nicola Nicolai, Kathleen Olson, Pia Paffenholz, James Porter, Zhiyu Qian, Nicholas R. Rocco, Anirudh Yerrapragada, Sean P. Stroup, Isamu Tachibana, Angelika Terbuch, Nirmish Singla, Clint Cary, Christian D. Fankhauser
To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.
{"title":"Primary retroperitoneal lymph node dissection in clinical stage 2a/b non-seminomatous germ cell tumour","authors":"Luca Antonelli, Axel Heidenreich, Aditya Bagrodia, Armon Amini, Fady Baky, Nicolas Branger, Walter Cazzaniga, Timothy N. Clinton, Siamak Daneshmand, Hooman Djaladat, Scott Eggener, Alireza Ghoreifi, Robert J. Hamilton, Matthew Ho, Wade J. Sexton, Sebastiano Nazzani, David Nicol, Nicola Nicolai, Kathleen Olson, Pia Paffenholz, James Porter, Zhiyu Qian, Nicholas R. Rocco, Anirudh Yerrapragada, Sean P. Stroup, Isamu Tachibana, Angelika Terbuch, Nirmish Singla, Clint Cary, Christian D. Fankhauser","doi":"10.1111/bju.16618","DOIUrl":"https://doi.org/10.1111/bju.16618","url":null,"abstract":"To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"11 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comment on: ‘Prevalence of urolithiasis in China: a systematic review and meta‐analysis’","authors":"Rachana Mehta, Ashok Kumar Balaraman, Ganesh Bushi, Sanjit Sah","doi":"10.1111/bju.16613","DOIUrl":"https://doi.org/10.1111/bju.16613","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"2 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David G. Gelikman, William S. Azar, Enis C. Yilmaz, Yue Lin, Luke A. Shumaker, Andrew M. Fang, Stephanie A. Harmon, Erich P. Huang, Sahil H. Parikh, Jason A. Hyman, Kyle Schuppe, Jeffrey W. Nix, Samuel J. Galgano, Maria J. Merino, Peter L. Choyke, Sandeep Gurram, Bradford J. Wood, Soroush Rais-Bahrami, Peter A. Pinto, Baris Turkbey
To develop and validate a Prostate Imaging-Reporting and Data System (PI-RADS) version 2.1 (v2.1)-based predictive model for diagnosis of clinically significant prostate cancer (csPCa), integrating clinical and multiparametric magnetic resonance imaging (mpMRI) data, and compare its performance with existing models.
{"title":"A Prostate Imaging-Reporting and Data System version 2.1-based predictive model for clinically significant prostate cancer diagnosis","authors":"David G. Gelikman, William S. Azar, Enis C. Yilmaz, Yue Lin, Luke A. Shumaker, Andrew M. Fang, Stephanie A. Harmon, Erich P. Huang, Sahil H. Parikh, Jason A. Hyman, Kyle Schuppe, Jeffrey W. Nix, Samuel J. Galgano, Maria J. Merino, Peter L. Choyke, Sandeep Gurram, Bradford J. Wood, Soroush Rais-Bahrami, Peter A. Pinto, Baris Turkbey","doi":"10.1111/bju.16616","DOIUrl":"https://doi.org/10.1111/bju.16616","url":null,"abstract":"To develop and validate a Prostate Imaging-Reporting and Data System (PI-RADS) version 2.1 (v2.1)-based predictive model for diagnosis of clinically significant prostate cancer (csPCa), integrating clinical and multiparametric magnetic resonance imaging (mpMRI) data, and compare its performance with existing models.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"20 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eiftu S. Haile, Zaeem Lone, David Shin, Amy S. Nowacki, Nicolas Soputro, Kyle Harris, Rebecca A. Campbell, Andrew Wood, Samuel C. Haywood, Mohamed Eltemamy, Georges-Pascal Haber, Christopher J. Weight, Hadley M. Wood, Jonathan J. Taliercio, Amanda Nizam, Shilpa Gupta, Erick M. Remer, Nima Almassi
To assess whether the effect of sarcopenia on neoadjuvant chemotherapy (NAC) toxicity is modified by borderline renal function (estimated glomerular filtration rate [eGFR] 40–65 mL/min) and whether sarcopenia and borderline renal function are independently associated with NAC toxicity risk.
{"title":"Sarcopenia may increase cisplatin toxicity in bladder cancer patients with borderline renal function","authors":"Eiftu S. Haile, Zaeem Lone, David Shin, Amy S. Nowacki, Nicolas Soputro, Kyle Harris, Rebecca A. Campbell, Andrew Wood, Samuel C. Haywood, Mohamed Eltemamy, Georges-Pascal Haber, Christopher J. Weight, Hadley M. Wood, Jonathan J. Taliercio, Amanda Nizam, Shilpa Gupta, Erick M. Remer, Nima Almassi","doi":"10.1111/bju.16606","DOIUrl":"https://doi.org/10.1111/bju.16606","url":null,"abstract":"To assess whether the effect of sarcopenia on neoadjuvant chemotherapy (NAC) toxicity is modified by borderline renal function (estimated glomerular filtration rate [eGFR] 40–65 mL/min) and whether sarcopenia and borderline renal function are independently associated with NAC toxicity risk.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"117 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kennedy E. Okhawere, Shirin Razdan, Alp Tuna Beksac, Indu Saini, Laura Zuluaga, Kirolos Meilika, Burak Ucpinar, Ren-Dih Sheu, Reza Mehrazin, John Sfakianos, Ashutosh Tewari, Richard G. Stock, Ketan Badani
To investigate the safety and cancer control of a novel bioabsorbable, low-dose rate brachytherapy device, CivaSheet® (CivaTech Oncology Inc., Durham, NC, USA), in combination with radical prostatectomy (RP) with or without adjuvant external beam radiation therapy (EBRT) for the management of prostate cancer (PCa).
{"title":"Novel bioabsorbable, low-dose rate brachytherapy device (CivaSheet®) with radical prostatectomy and adjuvant external beam radiation for the management of prostate cancer","authors":"Kennedy E. Okhawere, Shirin Razdan, Alp Tuna Beksac, Indu Saini, Laura Zuluaga, Kirolos Meilika, Burak Ucpinar, Ren-Dih Sheu, Reza Mehrazin, John Sfakianos, Ashutosh Tewari, Richard G. Stock, Ketan Badani","doi":"10.1111/bju.16617","DOIUrl":"https://doi.org/10.1111/bju.16617","url":null,"abstract":"To investigate the safety and cancer control of a novel bioabsorbable, low-dose rate brachytherapy device, CivaSheet<sup>®</sup> (CivaTech Oncology Inc., Durham, NC, USA), in combination with radical prostatectomy (RP) with or without adjuvant external beam radiation therapy (EBRT) for the management of prostate cancer (PCa).","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"67 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomas Andri Axelsson, Filip Sydén, Jesper Eisfeldt, Ylva Eriksson, Gustav Göthner Lundberg, Georg Jaremko, Ollanta Cuba Gyllensten, Emma Tham, Marianne Brehmer
To investigate whether genetic analysis of focal barbotage samples obtained at ureterorenoscopy (URS) is possible, and to identify genetic aberrations that might add prognostic information.
{"title":"Diagnostic and prognostic genomic aberrations in upper tract urothelial carcinoma can be identified in focal barbotage samples","authors":"Tomas Andri Axelsson, Filip Sydén, Jesper Eisfeldt, Ylva Eriksson, Gustav Göthner Lundberg, Georg Jaremko, Ollanta Cuba Gyllensten, Emma Tham, Marianne Brehmer","doi":"10.1111/bju.16620","DOIUrl":"https://doi.org/10.1111/bju.16620","url":null,"abstract":"To investigate whether genetic analysis of focal barbotage samples obtained at ureterorenoscopy (URS) is possible, and to identify genetic aberrations that might add prognostic information.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"49 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"January's reviewers of the month","authors":"","doi":"10.1111/bju.16614","DOIUrl":"https://doi.org/10.1111/bju.16614","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"9 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katie Du, Michael Uy, Alan Cheng, Braden Millan, Bobby Shayegan, Edward Matsumoto
ObjectivesTo investigate the differences in perioperative characteristics and postoperative outcomes between inpatient and ambulatory percutaneous nephrolithotomy (PCNL) with a subgroup analysis of same‐day discharge (SDD) patients, summarise published ambulatory pathways and compare cost and satisfaction data.Patients and MethodsThis study was completed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines and registered a priori with the International Prospective Register of Systematic Reviews (PROSPERO: CRD42023438692). Ambulatory PCNL was defined as patients who were discharged after an overnight stay (≤23 h) and SDD was considered a subgroup discharged on postoperative Day 0.ResultsA total of 25 studies were included in the systematic review, of which 12 comparative studies were utilised for meta‐analysis. We had a pooled population of 2463 patients, of which 1956 (79%) ambulatory (747 [30%] SDD) and 507 (21%) inpatients. The ambulatory PCNL cohort had fewer overall complications (risk ratio [RR] 0.65, 95% confidence interval [CI] 0.47–0.90; P = 0.010); however, there were no differences in major complications (i.e., Clavien–Dindo Grade ≥III; RR 0.46; 95% CI 0.17–1.21; P = 0.12), emergency department visits (RR 1.09, 95% CI 0.69–1.74; P = 0.71), 30‐day readmission (RR 1.09, 95% CI 0.54–2.21; P = 0.81) or readmission at any point (RR 1.00, 95% CI 0.53–1.88; P = 0.99). The ambulatory PCNL cohort was more likely to be stone‐free defined by imaging (RR 1.35, 95% CI 1.09–1.66; P = 0.005); however, when stone‐free was inclusive of any definition there was no difference in stone‐free rates (RR 1.10, 95% CI 0.98–1.23; P = 0.10). Subgroup analysis of SDD did not result in any significant differences. Cost savings ranged from $932.37 to a mean (standard deviation) $5327 (442) United States Dollars per case. No studies reported patient satisfaction data.ConclusionsAmbulatory PCNL seems to be a safe and efficacious model for select patients. Selection bias likely influenced ambulatory outcomes; however, this supports overall safety of current ambulatory inclusion criteria.
目的通过对当日出院（SDD）患者的亚组分析，探讨住院和门诊经皮肾镜取石术（PCNL）围手术期特征和术后结局的差异，总结已发表的门诊路径，并比较成本和满意度数据。患者和方法本研究按照系统评价和Meta分析指南的首选报告项目完成，并在国际前瞻性系统评价注册（PROSPERO: CRD42023438692）进行了先验注册。门诊PCNL定义为住院过夜（≤23 h）后出院的患者，SDD被认为是术后第0天出院的亚组。结果系统评价共纳入25项研究，其中12项比较研究用于meta分析。我们收集了2463例患者，其中1956例（79%）门诊患者（747例[30%]SDD）和507例（21%）住院患者。门诊PCNL队列总体并发症较少(风险比[RR] 0.65, 95%可信区间[CI] 0.47-0.90；P = 0.010)；然而，主要并发症(即Clavien-Dindo Grade≥III；RR 0.46;95% ci 0.17-1.21；P = 0.12)，急诊科就诊(RR 1.09, 95% CI 0.69-1.74；P = 0.71)， 30天再入院(RR 1.09, 95% CI 0.54-2.21；P = 0.81)或在任何时间再次入院(RR 1.00, 95% CI 0.53-1.88；P = 0.99)。门诊PCNL队列更有可能通过影像学定义为无结石(RR 1.35, 95% CI 1.09-1.66；P = 0.005)；然而，当无结石包括任何定义时，无结石率没有差异(RR 1.10, 95% CI 0.98-1.23；P = 0.10)。SDD的亚组分析没有发现任何显著差异。每箱节省的费用从932.37美元到平均（标准差）5327美元不等。没有研究报告患者满意度数据。结论抽血PCNL是一种安全、有效的治疗方法。选择偏差可能影响门诊结果；然而，这支持了当前门诊纳入标准的总体安全性。
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