首页 > 最新文献

BMC Psychiatry最新文献

英文 中文
Associations of generalized anxiety and social anxiety symptoms with sleep duration, amount of intense exercise, and excessive internet use among adolescents. 青少年普遍焦虑和社交焦虑症状与睡眠时间、剧烈运动量和过度使用互联网的关系。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1186/s12888-024-06231-y
Kati Kajastus, Olli Kiviruusu, Mauri Marttunen, Klaus Ranta

Background: Among adolescents, symptoms of generalized anxiety disorder (GAD) and social anxiety disorder (SAD) are not only clinically significant but also continuingly increasing. During adolescence, individuals begin to establish distinct, self-determined lifestyle patterns. This study seeks to identify the associations between such lifestyle factors and the prevalence of GAD and SAD symptoms.

Methods: The analyzable sample was based on a cross-sectional, nationally representative survey of Finnish 14-18 year old students from comprehensive schools, general upper secondary schools, and vocational institutions. The sample consisted of 60,252 boys and 71,118 girls, with the mean age of 16.05 years (standard deviation 1.06). Symptoms were identified using the GAD-7 (cutpoint of 10), the Mini-SPIN (cutpoint of 6), and the PHQ-2 (cutpoint of 3). Logistic regression models for both GAD and SAD symptoms were stratified by comorbidity group variables.

Results: GAD symptoms were closely related to excessive internet use and decreased sleep duration among adolescents, regardless of comorbidity with depression or SAD. SAD symptoms were associated with excessive internet use and a lack of intense exercise, independent of comorbid depression or GAD.

Conclusions: The findings underscore the importance of considering lifestyle factors when developing interventions to mitigate GAD and SAD symptoms in adolescents. Interventions and policy recommendations aiming at improving adolescents' health behaviour and mental health should take into account the intertwining of these factors.

背景:在青少年中,广泛性焦虑症(GAD)和社交焦虑症(SAD)的症状不仅具有显著的临床意义,而且还在不断增加。在青春期,个人开始建立独特的、自我决定的生活方式。本研究旨在确定这些生活方式因素与 GAD 和 SAD 症状发生率之间的关联:可分析的样本是基于一项横断面、具有全国代表性的调查,调查对象是来自综合学校、普通高中和职业院校的 14-18 岁芬兰学生。样本包括 60,252 名男生和 71,118 名女生,平均年龄为 16.05 岁(标准差为 1.06)。使用 GAD-7(切点为 10)、Mini-SPIN(切点为 6)和 PHQ-2(切点为 3)对症状进行识别。根据合并症组变量对 GAD 和 SAD 症状的逻辑回归模型进行了分层:结果:无论青少年是否合并抑郁症或 SAD,GAD 症状都与过度上网和睡眠时间减少密切相关。SAD症状与过度使用互联网和缺乏剧烈运动有关,与合并抑郁症或GAD无关:研究结果强调,在制定干预措施以减轻青少年的GAD和SAD症状时,考虑生活方式因素非常重要。旨在改善青少年健康行为和心理健康的干预措施和政策建议应考虑到这些因素的相互交织。
{"title":"Associations of generalized anxiety and social anxiety symptoms with sleep duration, amount of intense exercise, and excessive internet use among adolescents.","authors":"Kati Kajastus, Olli Kiviruusu, Mauri Marttunen, Klaus Ranta","doi":"10.1186/s12888-024-06231-y","DOIUrl":"10.1186/s12888-024-06231-y","url":null,"abstract":"<p><strong>Background: </strong>Among adolescents, symptoms of generalized anxiety disorder (GAD) and social anxiety disorder (SAD) are not only clinically significant but also continuingly increasing. During adolescence, individuals begin to establish distinct, self-determined lifestyle patterns. This study seeks to identify the associations between such lifestyle factors and the prevalence of GAD and SAD symptoms.</p><p><strong>Methods: </strong>The analyzable sample was based on a cross-sectional, nationally representative survey of Finnish 14-18 year old students from comprehensive schools, general upper secondary schools, and vocational institutions. The sample consisted of 60,252 boys and 71,118 girls, with the mean age of 16.05 years (standard deviation 1.06). Symptoms were identified using the GAD-7 (cutpoint of 10), the Mini-SPIN (cutpoint of 6), and the PHQ-2 (cutpoint of 3). Logistic regression models for both GAD and SAD symptoms were stratified by comorbidity group variables.</p><p><strong>Results: </strong>GAD symptoms were closely related to excessive internet use and decreased sleep duration among adolescents, regardless of comorbidity with depression or SAD. SAD symptoms were associated with excessive internet use and a lack of intense exercise, independent of comorbid depression or GAD.</p><p><strong>Conclusions: </strong>The findings underscore the importance of considering lifestyle factors when developing interventions to mitigate GAD and SAD symptoms in adolescents. Interventions and policy recommendations aiming at improving adolescents' health behaviour and mental health should take into account the intertwining of these factors.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"791"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive analysis of psychological symptoms and quality of life in early patients with IBD: a multicenter study from China. 综合分析早期 IBD 患者的心理症状和生活质量:一项来自中国的多中心研究。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1186/s12888-024-06247-4
Yupei Liu, Jiaming Hu, Shan Tian, Jixiang Zhang, Ping An, Yanrui Wu, Zhongchun Liu, Changqing Jiang, Jie Shi, Kaichun Wu, Weiguo Dong

Objective: To investigate the prevalence and risk factors of psychological symptoms and quality of life (QoL) in early patients with inflammatory bowel disease (IBD).

Methods: From September 2021 to May 2022, a unified questionnaire was developed to collect clinical data from early patients with IBD from 42 tertiary care hospitals. The influencing factors of psychological symptoms and poor QoL are screened by logistic regression analysis for constructing model in predicting poor QoL. The consistency index, receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), net reclassification improvement (NRI), integrated discrimination improvement (IDI), calibration curve, and decision curve analysis (DCA) were used to evaluate the performance of the model.

Results: A total of 939 early patients with IBD were surveyed, Among them, 20.3% exhibited anxiety, 21.7% had depression, 57.3% experienced sleep disturbance, and 41.9% reported poor QoL. The factors influencing psychological symptoms varied between ulcerative colitis (UC) and Crohn's disease (CD) patients. The QoL was primarily affected by disease activity, income level and depression. The AUC value of the model in the training group was 0.781 (95% CI: 0.748-0.814). The calibration diagram of the model closely matched the ideal curve. Compared to other prediction models, our model showed superior predictive capability, with NRI and IDI values of 0.324 (95%CI:0.196-0.4513) and 0.026 (95%CI:0.014-0.038), respectively. DCA indicated that the nomogram model could provide clinical benefits.

Conclusion: Early patients with IBD exhibit a high prevalence of psychological symptoms and poor QoL. The nomogram prediction model we constructed demonstrates high accuracy and performance in predicting QoL in early patients with IBD.

目的研究早期炎症性肠病(IBD)患者心理症状和生活质量(QoL)的患病率和风险因素:方法:从 2021 年 9 月至 2022 年 5 月,编制统一的调查问卷,收集 42 家三级医院早期 IBD 患者的临床数据。方法:于 2021 年 9 月至 2022 年 5 月对 42 家三级甲等医院的早期 IBD 患者进行统一问卷调查,并通过逻辑回归分析筛选心理症状和 QoL 差异的影响因素,建立 QoL 差异预测模型。采用一致性指数、接收者操作特征曲线(ROC)、ROC曲线下面积(AUC)、净再分类改进(NRI)、综合分辨改进(IDI)、校准曲线和决策曲线分析(DCA)来评价模型的性能:共调查了 939 名早期 IBD 患者,其中 20.3% 的人表现出焦虑,21.7% 的人患有抑郁症,57.3% 的人有睡眠障碍,41.9% 的人表示生活质量差。影响溃疡性结肠炎(UC)和克罗恩病(CD)患者心理症状的因素各不相同。生活质量主要受疾病活动、收入水平和抑郁的影响。训练组模型的 AUC 值为 0.781(95% CI:0.748-0.814)。模型的校准图与理想曲线非常吻合。与其他预测模型相比,我们的模型显示出更强的预测能力,NRI 和 IDI 值分别为 0.324(95%CI:0.196-0.4513)和 0.026(95%CI:0.014-0.038)。DCA表明,提名图模型可为临床带来益处:结论:早期 IBD 患者表现出较高的心理症状发生率和较差的生活质量。我们构建的提名图预测模型在预测早期 IBD 患者的 QoL 方面具有很高的准确性和性能。
{"title":"Comprehensive analysis of psychological symptoms and quality of life in early patients with IBD: a multicenter study from China.","authors":"Yupei Liu, Jiaming Hu, Shan Tian, Jixiang Zhang, Ping An, Yanrui Wu, Zhongchun Liu, Changqing Jiang, Jie Shi, Kaichun Wu, Weiguo Dong","doi":"10.1186/s12888-024-06247-4","DOIUrl":"10.1186/s12888-024-06247-4","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence and risk factors of psychological symptoms and quality of life (QoL) in early patients with inflammatory bowel disease (IBD).</p><p><strong>Methods: </strong>From September 2021 to May 2022, a unified questionnaire was developed to collect clinical data from early patients with IBD from 42 tertiary care hospitals. The influencing factors of psychological symptoms and poor QoL are screened by logistic regression analysis for constructing model in predicting poor QoL. The consistency index, receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), net reclassification improvement (NRI), integrated discrimination improvement (IDI), calibration curve, and decision curve analysis (DCA) were used to evaluate the performance of the model.</p><p><strong>Results: </strong>A total of 939 early patients with IBD were surveyed, Among them, 20.3% exhibited anxiety, 21.7% had depression, 57.3% experienced sleep disturbance, and 41.9% reported poor QoL. The factors influencing psychological symptoms varied between ulcerative colitis (UC) and Crohn's disease (CD) patients. The QoL was primarily affected by disease activity, income level and depression. The AUC value of the model in the training group was 0.781 (95% CI: 0.748-0.814). The calibration diagram of the model closely matched the ideal curve. Compared to other prediction models, our model showed superior predictive capability, with NRI and IDI values of 0.324 (95%CI:0.196-0.4513) and 0.026 (95%CI:0.014-0.038), respectively. DCA indicated that the nomogram model could provide clinical benefits.</p><p><strong>Conclusion: </strong>Early patients with IBD exhibit a high prevalence of psychological symptoms and poor QoL. The nomogram prediction model we constructed demonstrates high accuracy and performance in predicting QoL in early patients with IBD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"792"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The voice of depression: speech features as biomarkers for major depressive disorder. 抑郁症的声音:作为重度抑郁症生物标志物的语言特征。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1186/s12888-024-06253-6
Felix Menne, Felix Dörr, Julia Schräder, Johannes Tröger, Ute Habel, Alexandra König, Lisa Wagels

Background: Psychiatry faces a challenge due to the lack of objective biomarkers, as current assessments are based on subjective evaluations. Automated speech analysis shows promise in detecting symptom severity in depressed patients. This project aimed to identify discriminating speech features between patients with major depressive disorder (MDD) and healthy controls (HCs) by examining associations with symptom severity measures.

Methods: Forty-four MDD patients from the Psychiatry Department, University Hospital Aachen, Germany and fifty-two HCs were recruited. Participants described positive and negative life events, which were recorded for analysis. The Beck Depression Inventory (BDI-II) and the Hamilton Rating Scale for Depression gauged depression severity. Transcribed audio recordings underwent feature extraction, including acoustics, speech rate, and content. Machine learning models including speech features and neuropsychological assessments, were used to differentiate between the MDD patients and HCs.

Results: Acoustic variables such as pitch and loudness differed significantly between the MDD patients and HCs (effect sizes 𝜼2 between 0.183 and 0.3, p < 0.001). Furthermore, variables pertaining to temporality, lexical richness, and speech sentiment displayed moderate to high effect sizes (𝜼2 between 0.062 and 0.143, p < 0.02). A support vector machine (SVM) model based on 10 acoustic features showed a high performance (AUC = 0.93) in differentiating between HCs and patients with MDD, comparable to an SVM based on the BDI-II (AUC = 0.99, p = 0.01).

Conclusions: This study identified robust speech features associated with MDD. A machine learning model based on speech features yielded similar results to an established pen-and-paper depression assessment. In the future, these findings may shape voice-based biomarkers, enhancing clinical diagnosis and MDD monitoring.

背景:精神病学由于缺乏客观的生物标志物而面临挑战,因为目前的评估都是基于主观评价。自动语音分析有望检测抑郁症患者的症状严重程度。本项目旨在通过研究与症状严重程度测量的关联,确定重度抑郁症(MDD)患者和健康对照组(HCs)之间的辨别语音特征:方法:招募了德国亚琛大学医院精神科的 44 名重度抑郁症患者和 52 名健康对照者。参与者描述了积极和消极的生活事件,并将其记录下来进行分析。贝克抑郁量表(BDI-II)和汉密尔顿抑郁评定量表可衡量抑郁的严重程度。转录的音频录音进行了特征提取,包括声学、语速和内容。机器学习模型包括语音特征和神经心理学评估,用于区分 MDD 患者和 HCs:结果:音调和响度等声学变量在 MDD 患者和 HCs 之间存在显著差异(效应大小 𝜼2 在 0.183 和 0.3 之间,p 结论:该研究发现了与 MDD 患者和 HCs 相关的强大语音特征:本研究发现了与 MDD 相关的强大语音特征。基于语音特征的机器学习模型得出了与纸笔抑郁评估相似的结果。未来,这些发现可能会形成基于语音的生物标志物,从而加强临床诊断和 MDD 监测。
{"title":"The voice of depression: speech features as biomarkers for major depressive disorder.","authors":"Felix Menne, Felix Dörr, Julia Schräder, Johannes Tröger, Ute Habel, Alexandra König, Lisa Wagels","doi":"10.1186/s12888-024-06253-6","DOIUrl":"10.1186/s12888-024-06253-6","url":null,"abstract":"<p><strong>Background: </strong>Psychiatry faces a challenge due to the lack of objective biomarkers, as current assessments are based on subjective evaluations. Automated speech analysis shows promise in detecting symptom severity in depressed patients. This project aimed to identify discriminating speech features between patients with major depressive disorder (MDD) and healthy controls (HCs) by examining associations with symptom severity measures.</p><p><strong>Methods: </strong>Forty-four MDD patients from the Psychiatry Department, University Hospital Aachen, Germany and fifty-two HCs were recruited. Participants described positive and negative life events, which were recorded for analysis. The Beck Depression Inventory (BDI-II) and the Hamilton Rating Scale for Depression gauged depression severity. Transcribed audio recordings underwent feature extraction, including acoustics, speech rate, and content. Machine learning models including speech features and neuropsychological assessments, were used to differentiate between the MDD patients and HCs.</p><p><strong>Results: </strong>Acoustic variables such as pitch and loudness differed significantly between the MDD patients and HCs (effect sizes 𝜼2 between 0.183 and 0.3, p < 0.001). Furthermore, variables pertaining to temporality, lexical richness, and speech sentiment displayed moderate to high effect sizes (𝜼2 between 0.062 and 0.143, p < 0.02). A support vector machine (SVM) model based on 10 acoustic features showed a high performance (AUC = 0.93) in differentiating between HCs and patients with MDD, comparable to an SVM based on the BDI-II (AUC = 0.99, p = 0.01).</p><p><strong>Conclusions: </strong>This study identified robust speech features associated with MDD. A machine learning model based on speech features yielded similar results to an established pen-and-paper depression assessment. In the future, these findings may shape voice-based biomarkers, enhancing clinical diagnosis and MDD monitoring.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"794"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of routine health monitoring for metabolic disorders in patients with serious mental illness on psychotropic medications: a study from Ethiopia. 对服用精神药物的重症精神病患者进行常规代谢紊乱健康监测的评估:埃塞俄比亚的一项研究。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1186/s12888-024-06266-1
Tirsit Ketsela Zeleke, Abel Hedato Teshome, Meron Tademe Assefa, Gashaw Sisay Chanie, Rahel Belete Abebe

Background: Compared to the overall population, patients with mental health problems are more likely to experience concurrent physical illnesses, poorer health outcomes, and mortality. Psychotropic medications, which are the pillars in the management of mental health conditions, are associated with adverse effects such as weight gain, an increased level of glucose, and elevated circulating lipid levels, all of which contribute to metabolic disorders. Inadequate health monitoring may led to suboptimal interventions and worsening of these conditions. However, there is a lack of studies assessing routine health monitoring practices for metabolic disorders and their determinants among patients with serious mental illnesses taking psychotropic medications in Ethiopia. This study aimed to evaluate routine health monitoring for metabolic disorders and its determinants in patients with serious mental illnesses on psychotropic medications in Ethiopia.

Method: A hospital based prospective follow-up study was conducted among patients with serious mental illness taking psychotropic medications who attended the outpatient psychiatry department at Debre Markos Comprehensive Specialized Hospital. Eligible participants were selected using a simple random sampling technique. Routine health monitoring was evaluated using guidelines and previous literature. Binary logistic regression was employed to identify the determinants of routine health monitoring, with statistical significance determined by a p-value of less than 0.05 and a 95% confidence interval (CI).

Results: The overall routine health monitoring practice for metabolic disorders was found to be sub-optimal. Vital signs were the most commonly assessed parameters. Key determinants of routine health monitoring included participants aged 45 and above (AOR (95% CI): 2.82 (1.34-5.92), having social insurance (AOR (95% CI): 2.94 (1.86-4.64), availability of laboratory tests at the hospital (AOR (95% CI): 3.46 (2.16-5.55), and reporting of medication-related side effects (AOR (95% CI): 1.96 (1.21-3.17)).

Conclusion: Routine health monitoring for metabolic disorders in patients with serious mental illnesses attending the outpatient psychiatry department was inadequate. Health care providers should give more attention to younger patients, those without health insurance, and who are not reported side effects. These findings provide crucial insights for improving routine health monitoring and promoting better health outcomes.

背景:与总体人群相比,有精神健康问题的患者更有可能同时患有躯体疾病,健康状况更差,死亡率更高。精神药物是治疗精神疾病的主要药物,但也会产生不良反应,如体重增加、血糖升高和循环血脂升高,所有这些都会导致代谢紊乱。健康监测不足可能会导致干预效果不佳和病情恶化。然而,目前还缺乏对埃塞俄比亚服用精神药物的重症精神病患者进行代谢紊乱及其决定因素的常规健康监测方法进行评估的研究。本研究旨在评估埃塞俄比亚服用精神药物的重症精神病患者代谢紊乱的常规健康监测及其决定因素:方法:对在 Debre Markos 综合专科医院精神科门诊就诊的服用精神药物的重症精神病患者进行了一项基于医院的前瞻性随访研究。采用简单随机抽样技术选出了符合条件的参与者。采用指南和以往文献对常规健康监测进行了评估。采用二元逻辑回归法确定常规健康监测的决定因素,统计意义由小于 0.05 的 p 值和 95% 的置信区间 (CI) 决定:结果表明:代谢性疾病的常规健康监测实践总体上并不理想。生命体征是最常评估的参数。常规健康监测的主要决定因素包括:参与者年龄在 45 岁及以上(AOR (95% CI):2.82 (1.34-5.92))、拥有社会保险(AOR (95% CI):2.94 (1.86-4.64))、医院提供实验室检测(AOR (95% CI):3.46 (2.16-5.55))以及报告药物相关副作用(AOR (95% CI):1.96 (1.21-3.17)):结论:对在精神科门诊就诊的重症精神病患者进行常规代谢紊乱健康监测是不够的。医疗服务提供者应更多地关注年轻患者、没有医疗保险的患者以及未报告副作用的患者。这些发现为改善常规健康监测和促进更好的健康结果提供了重要启示。
{"title":"Evaluation of routine health monitoring for metabolic disorders in patients with serious mental illness on psychotropic medications: a study from Ethiopia.","authors":"Tirsit Ketsela Zeleke, Abel Hedato Teshome, Meron Tademe Assefa, Gashaw Sisay Chanie, Rahel Belete Abebe","doi":"10.1186/s12888-024-06266-1","DOIUrl":"10.1186/s12888-024-06266-1","url":null,"abstract":"<p><strong>Background: </strong>Compared to the overall population, patients with mental health problems are more likely to experience concurrent physical illnesses, poorer health outcomes, and mortality. Psychotropic medications, which are the pillars in the management of mental health conditions, are associated with adverse effects such as weight gain, an increased level of glucose, and elevated circulating lipid levels, all of which contribute to metabolic disorders. Inadequate health monitoring may led to suboptimal interventions and worsening of these conditions. However, there is a lack of studies assessing routine health monitoring practices for metabolic disorders and their determinants among patients with serious mental illnesses taking psychotropic medications in Ethiopia. This study aimed to evaluate routine health monitoring for metabolic disorders and its determinants in patients with serious mental illnesses on psychotropic medications in Ethiopia.</p><p><strong>Method: </strong>A hospital based prospective follow-up study was conducted among patients with serious mental illness taking psychotropic medications who attended the outpatient psychiatry department at Debre Markos Comprehensive Specialized Hospital. Eligible participants were selected using a simple random sampling technique. Routine health monitoring was evaluated using guidelines and previous literature. Binary logistic regression was employed to identify the determinants of routine health monitoring, with statistical significance determined by a p-value of less than 0.05 and a 95% confidence interval (CI).</p><p><strong>Results: </strong>The overall routine health monitoring practice for metabolic disorders was found to be sub-optimal. Vital signs were the most commonly assessed parameters. Key determinants of routine health monitoring included participants aged 45 and above (AOR (95% CI): 2.82 (1.34-5.92), having social insurance (AOR (95% CI): 2.94 (1.86-4.64), availability of laboratory tests at the hospital (AOR (95% CI): 3.46 (2.16-5.55), and reporting of medication-related side effects (AOR (95% CI): 1.96 (1.21-3.17)).</p><p><strong>Conclusion: </strong>Routine health monitoring for metabolic disorders in patients with serious mental illnesses attending the outpatient psychiatry department was inadequate. Health care providers should give more attention to younger patients, those without health insurance, and who are not reported side effects. These findings provide crucial insights for improving routine health monitoring and promoting better health outcomes.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"795"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
University students who were men who had sex with men (MSM) in Sichuan, China had a higher prevalence of insomnia and probable depression than their non-MSM counterparts: mediation via emotional dysregulations. 与非男男性行为者相比,中国四川的男男性行为者(MSM)大学生失眠和抑郁的发生率更高:通过情绪失调进行调解。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1186/s12888-024-06192-2
Yanqiu Yu, Joyce Hoi-Yuk Ng, Zixin Wang, Xiaobing Tian, Joseph T F Lau

Background: Men who have sex with men studying in universities (MSM-US) frequently face multiple sexual minority stressors that potentially lead to maladaptive emotional regulations and mental problems. This study compared the prevalence of depression/insomnia between MSM-US and non-MSM male university students (NUS) and hypothesized that the potential differences would be mediated via emotional dysregulation styles (rumination and catastrophizing).

Methods: The study design was a cross-sectional study. NUS were recruited from a university-based survey using cluster sampling in three universities in China from June to October 2018, while MSM-US from the same university-based survey and the other community-based survey using convenience sampling. The effective samples size was 2,531 (292 MSM-US and 2,239 NUS). Structural equation modeling (SEM) was performed.

Results: MSM-US had significantly higher prevalence of both probable depression (55.1% versus 35.7%; OR = 4.85, 95% CI: 3.38-6.94) and moderate-to-severe clinical insomnia (17.3% versus 4.1%; OR = 2.21, 95% CI: 1.73-2.83) than NUS. MSM-US were also more likely than NUS to use emotional dysregulation styles (rumination/catastrophizing), which were correlated with probable depression/insomnia (r = 0.17 to 0.31). In the SEM, the differences in depression/insomnia between MSM-US and NUS were partially mediated by the latent variable of emotional dysregulation (rumination and catastrophizing), with effect sizes of 55.0% for probable depression and 33.6% for insomnia, respectively.

Conclusions: Depression and insomnia were prevalent among male university students in Sichuan, China. Furthermore, MSM-US were at increased risk than NUS for both mental problems; emotional dysregulation partially explained such differences. Future studies are warranted to confirm the findings, develop tailored interventions to address general and MSM-specific stressors and reduce rumination and catastrophizing, and examine whether similar patterns exist in other sexual minority groups.

背景:在大学就读的男男性行为者(MSM-US)经常面临多重性少数群体压力,这些压力有可能导致适应不良的情绪调节和心理问题。本研究比较了男男性行为者(MSM-US)和非男男性行为者男大学生(NUS)的抑郁/失眠患病率,并假设潜在的差异将通过情绪失调方式(反刍和灾难化)来调节:研究设计为横断面研究。2018年6月至10月,在中国三所大学进行的一项基于大学的调查中,采用整群抽样的方式招募了NUS,而MSM-US则在同一大学的调查和另一项基于社区的调查中采用便利抽样的方式招募。有效样本量为2531个(292个MSM-US和2239个NUS)。研究采用了结构方程模型(SEM):美国男男性行为者可能患有抑郁症(55.1% 对 35.7%;OR = 4.85,95% CI:3.38-6.94)和中度至重度临床失眠(17.3% 对 4.1%;OR = 2.21,95% CI:1.73-2.83)的比例明显高于美国女性行为者。MSM-US 也比 NUS 更有可能使用情绪失调方式(反刍/自责),这与可能的抑郁/失眠相关(r = 0.17 至 0.31)。在 SEM 中,MSM-US 和 NUS 在抑郁/失眠方面的差异部分由情绪失调(反刍和灾难化)这一潜变量中介,其对可能抑郁和失眠的影响大小分别为 55.0% 和 33.6%:结论:抑郁和失眠在中国四川的男大学生中普遍存在。此外,MSM-US 比 NUS 在这两种精神问题上的风险更高;情绪失调是造成这种差异的部分原因。今后的研究需要证实这些发现,制定有针对性的干预措施,以解决一般和MSM特有的压力因素,减少反刍和灾难化,并研究其他性少数群体是否也存在类似的模式。
{"title":"University students who were men who had sex with men (MSM) in Sichuan, China had a higher prevalence of insomnia and probable depression than their non-MSM counterparts: mediation via emotional dysregulations.","authors":"Yanqiu Yu, Joyce Hoi-Yuk Ng, Zixin Wang, Xiaobing Tian, Joseph T F Lau","doi":"10.1186/s12888-024-06192-2","DOIUrl":"10.1186/s12888-024-06192-2","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men studying in universities (MSM-US) frequently face multiple sexual minority stressors that potentially lead to maladaptive emotional regulations and mental problems. This study compared the prevalence of depression/insomnia between MSM-US and non-MSM male university students (NUS) and hypothesized that the potential differences would be mediated via emotional dysregulation styles (rumination and catastrophizing).</p><p><strong>Methods: </strong>The study design was a cross-sectional study. NUS were recruited from a university-based survey using cluster sampling in three universities in China from June to October 2018, while MSM-US from the same university-based survey and the other community-based survey using convenience sampling. The effective samples size was 2,531 (292 MSM-US and 2,239 NUS). Structural equation modeling (SEM) was performed.</p><p><strong>Results: </strong>MSM-US had significantly higher prevalence of both probable depression (55.1% versus 35.7%; OR = 4.85, 95% CI: 3.38-6.94) and moderate-to-severe clinical insomnia (17.3% versus 4.1%; OR = 2.21, 95% CI: 1.73-2.83) than NUS. MSM-US were also more likely than NUS to use emotional dysregulation styles (rumination/catastrophizing), which were correlated with probable depression/insomnia (r = 0.17 to 0.31). In the SEM, the differences in depression/insomnia between MSM-US and NUS were partially mediated by the latent variable of emotional dysregulation (rumination and catastrophizing), with effect sizes of 55.0% for probable depression and 33.6% for insomnia, respectively.</p><p><strong>Conclusions: </strong>Depression and insomnia were prevalent among male university students in Sichuan, China. Furthermore, MSM-US were at increased risk than NUS for both mental problems; emotional dysregulation partially explained such differences. Future studies are warranted to confirm the findings, develop tailored interventions to address general and MSM-specific stressors and reduce rumination and catastrophizing, and examine whether similar patterns exist in other sexual minority groups.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"793"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engagement in a virtual group-based walking intervention for persons with schizophrenia: a qualitative study. 精神分裂症患者参与虚拟小组步行干预:一项定性研究。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-11 DOI: 10.1186/s12888-024-06250-9
Julia Browne, Claudio Battaglini, Aslihan Imamoglu, Bryan Stiles, L Fredrik Jarskog, Paschal Sheeran, Ana M Abrantes, Tonya Elliott, Oscar Gonzalez, David L Penn

Background: Exercise is beneficial for persons with schizophrenia; however, high dropout rates limit the impact of interventions. Virtual exercise programs have the potential to improve engagement; however, few intervention studies of virtual programs have been conducted in this population.

Methods: This study examined qualitative data from 15 adults with schizophrenia who participated in a pilot randomized controlled trial of Virtual PACE-Life, a live, video-delivered group walking intervention guided by self-determination theory. Interviews elicited feedback on the intervention, barriers and facilitators to engagement, recommendations for intervention refinement, and preferences for exercise programming modality. Rapid qualitative analysis was used to explore similarities and differences between completers (i.e., those that attended ≥ 50% of virtual walking sessions; n = 9) and non-completers (i.e., those that attended < 50% of virtual walking sessions; n = 6).

Results: Both groups viewed Virtual PACE-Life positively but found the virtual exercise sessions challenging and inadequate for facilitating social interaction. Work obligations impacted completers' attendance whereas technological issues and forgetting impacted non-completers' attendance at virtual walking sessions. Completers preferred virtual exercise programs and non-completers preferred in-person exercise programs.

Conclusions: These findings suggest that future virtual group-based walking programs should prioritize enhancing the social aspect, offering scheduling choices, and regularly assessing the perceived difficulty of exercise sessions. These modifications not only have the potential to improve intervention engagement but they also may increase participant autonomy and relatedness, core components of self-determination theory.

背景:运动对精神分裂症患者有益;然而,高辍学率限制了干预措施的效果。虚拟运动项目具有提高参与度的潜力;然而,针对此类人群开展的虚拟项目干预研究却寥寥无几:本研究审查了 15 名成年精神分裂症患者的定性数据,这些患者参加了虚拟 PACE-Life 的试点随机对照试验。访谈内容包括对干预措施的反馈、参与的障碍和促进因素、改进干预措施的建议以及对运动编程模式的偏好。我们采用快速定性分析来探讨完成者(即参加虚拟步行课程≥50%者;n = 9)和未完成者(即参加结果)之间的异同:两组人都对虚拟 PACE-Life 持积极态度,但都认为虚拟锻炼课程具有挑战性,不足以促进社交互动。工作任务影响了完成者的出席率,而技术问题和遗忘则影响了未完成者对虚拟步行课程的出席率。完成者更喜欢虚拟锻炼项目,而未完成者更喜欢面对面锻炼项目:这些研究结果表明,未来的虚拟小组步行计划应优先考虑增强社交性、提供时间安排选择以及定期评估锻炼课程的难度。这些改进措施不仅有可能提高参与者的参与度,还能增强参与者的自主性和相关性,而这正是自我决定理论的核心内容。
{"title":"Engagement in a virtual group-based walking intervention for persons with schizophrenia: a qualitative study.","authors":"Julia Browne, Claudio Battaglini, Aslihan Imamoglu, Bryan Stiles, L Fredrik Jarskog, Paschal Sheeran, Ana M Abrantes, Tonya Elliott, Oscar Gonzalez, David L Penn","doi":"10.1186/s12888-024-06250-9","DOIUrl":"10.1186/s12888-024-06250-9","url":null,"abstract":"<p><strong>Background: </strong>Exercise is beneficial for persons with schizophrenia; however, high dropout rates limit the impact of interventions. Virtual exercise programs have the potential to improve engagement; however, few intervention studies of virtual programs have been conducted in this population.</p><p><strong>Methods: </strong>This study examined qualitative data from 15 adults with schizophrenia who participated in a pilot randomized controlled trial of Virtual PACE-Life, a live, video-delivered group walking intervention guided by self-determination theory. Interviews elicited feedback on the intervention, barriers and facilitators to engagement, recommendations for intervention refinement, and preferences for exercise programming modality. Rapid qualitative analysis was used to explore similarities and differences between completers (i.e., those that attended ≥ 50% of virtual walking sessions; n = 9) and non-completers (i.e., those that attended < 50% of virtual walking sessions; n = 6).</p><p><strong>Results: </strong>Both groups viewed Virtual PACE-Life positively but found the virtual exercise sessions challenging and inadequate for facilitating social interaction. Work obligations impacted completers' attendance whereas technological issues and forgetting impacted non-completers' attendance at virtual walking sessions. Completers preferred virtual exercise programs and non-completers preferred in-person exercise programs.</p><p><strong>Conclusions: </strong>These findings suggest that future virtual group-based walking programs should prioritize enhancing the social aspect, offering scheduling choices, and regularly assessing the perceived difficulty of exercise sessions. These modifications not only have the potential to improve intervention engagement but they also may increase participant autonomy and relatedness, core components of self-determination theory.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"790"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-rated scales improve the classification accuracy for patients with depression and anxiety disorder: a linear discriminant analysis. 患者评分量表提高了抑郁症和焦虑症患者分类的准确性:线性判别分析。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-11 DOI: 10.1186/s12888-024-06237-6
Shanling Ji, Jing Zhang, Cong Zhou, Min Chen, Hao Yu

Background: The current study aimed to investigate the performances of clinical scales rated by clinicians and patients as well as cognitive function tests in distinguishing patients with affective and anxiety disorders from healthy controls (HCs).

Methods: We recruited a total of 122 subjects, comprising 24 patients with bipolar disorder (BD), 34 patients with major depressive disorder (MDD), 29 patients with anxiety disorder (AD), and 35 matched HCs. Three clinician-rated scales and five patient-rated scales were used to quantify clinical symptoms, while four cognitive tests were employed to measure cognitive functions in all subjects. Fisher's discriminant analysis (FDA) was employed to distinguish patients from HCs, as well as to discriminate patient sub-groups from each other. In the FDA model, the prior probability of each group was set as 0.5 in the two-group classification and 0.25 in the four-group classification.

Results: The results showed that patient-rated scales achieved higher classification accuracies than clinician-rated scales in identifying MDD and AD from HCs. In contrast, cognitive tests exhibited the lowest accuracy.

Conclusions: These findings suggest that patient-rated scales might improve the classification accuracy for patients with MDD and AD.

研究背景本研究旨在探讨由临床医生和患者评定的临床量表以及认知功能测试在区分情感障碍和焦虑障碍患者与健康对照组(HCs)方面的表现:我们共招募了 122 名受试者,其中包括 24 名双相情感障碍(BD)患者、34 名重度抑郁障碍(MDD)患者、29 名焦虑障碍(AD)患者和 35 名匹配的健康对照者。研究使用了三个临床医生评分量表和五个患者评分量表来量化临床症状,并使用了四个认知测试来测量所有受试者的认知功能。采用费雪判别分析(FDA)来区分患者和 HC,以及患者亚组之间的区别。在 FDA 模型中,两组分类中每组的先验概率设为 0.5,四组分类中每组的先验概率设为 0.25:结果显示,在从 HCs 中识别 MDD 和 AD 时,患者评分量表的分类准确率高于临床医生评分量表。相比之下,认知测试的准确率最低:这些研究结果表明,患者评分量表可提高 MDD 和 AD 患者的分类准确性。
{"title":"Patient-rated scales improve the classification accuracy for patients with depression and anxiety disorder: a linear discriminant analysis.","authors":"Shanling Ji, Jing Zhang, Cong Zhou, Min Chen, Hao Yu","doi":"10.1186/s12888-024-06237-6","DOIUrl":"10.1186/s12888-024-06237-6","url":null,"abstract":"<p><strong>Background: </strong>The current study aimed to investigate the performances of clinical scales rated by clinicians and patients as well as cognitive function tests in distinguishing patients with affective and anxiety disorders from healthy controls (HCs).</p><p><strong>Methods: </strong>We recruited a total of 122 subjects, comprising 24 patients with bipolar disorder (BD), 34 patients with major depressive disorder (MDD), 29 patients with anxiety disorder (AD), and 35 matched HCs. Three clinician-rated scales and five patient-rated scales were used to quantify clinical symptoms, while four cognitive tests were employed to measure cognitive functions in all subjects. Fisher's discriminant analysis (FDA) was employed to distinguish patients from HCs, as well as to discriminate patient sub-groups from each other. In the FDA model, the prior probability of each group was set as 0.5 in the two-group classification and 0.25 in the four-group classification.</p><p><strong>Results: </strong>The results showed that patient-rated scales achieved higher classification accuracies than clinician-rated scales in identifying MDD and AD from HCs. In contrast, cognitive tests exhibited the lowest accuracy.</p><p><strong>Conclusions: </strong>These findings suggest that patient-rated scales might improve the classification accuracy for patients with MDD and AD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"785"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reasons for disengagement in first-episode psychosis - perspectives from service users and their caregivers. 首次发病的精神病患者脱离治疗的原因--服务使用者及其照顾者的观点。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-11 DOI: 10.1186/s12888-024-06190-4
Yi Chian Chua, Kumarasan Roystonn, K Pushpa, Swapna Verma, Charmaine Tang

Background: The efforts of early psychosis intervention programmes can be impeded by difficulties in maintaining the engagement of service users. As disengagement is often an autonomous decision made by service users, the main aim of this study was to gain insight into the reasons for service user disengagement through qualitative interviews with the service users themselves, and caregivers as proxies or secondary informants.

Methods: Participants recruited for the study were enrolled in the Early Psychosis Intervention Programme in Singapore for at least a year, aged 21 and above, able to communicate in English, and had disengaged for at least three months. The recruitment and interview processes were conducted independently for service user and caregiver participants. Potential participants were invited to a face-to-face semi-structured interview over video call or in-person. Each interview spanned one to two hours, and comprised five phases - icebreaker, exploration of the participant's experience with EPIP before deciding to disengage, discussion of reasons for disengagement, exploration of the post-disengagement experience, and feedback and suggestions for EPIP. Recruitment aimed to conclude after 10-15 participants were interviewed for both service user and caregiver groups, with the expectation that data sufficiency would be reached with no new themes being generated.

Results: Ultimately, 12 service user and 12 caregiver participants were recruited. There were six pairs of service user and caregiver dyads, where the caregivers interviewed were caring for service users also enrolled in the study. Valuable qualitative insights were gathered, including the type of disengagement, medication compliance during disengagement, the decision-making process behind disengaging, and circumstances surrounding re-engagement. A total of five categories each with subthemes were identified from the reasons for service user disengagement - individual factors, stigma, progression, treatment factors, and external factors.

Conclusions: There is a need to narrow down urgent areas of attention, aligning the study themes with established risk factors so that feasible solutions can be developed and appropriate care models can be adopted, to minimise adverse outcomes related to disengagement. It is important to keep an open mind to understand what personal recovery means to the individual service user, so that treatment goals can be better harmonised.

背景:由于难以保持服务使用者的参与,早期思觉失调干预计划的工作可能会受到阻碍。由于脱离通常是由服务使用者自主做出的决定,本研究的主要目的是通过对服务使用者本人以及作为代理人或次要信息提供者的照顾者进行定性访谈,深入了解服务使用者脱离的原因:本研究招募的参与者均已参加新加坡的早期思觉失调干预计划至少一年,年龄在 21 岁及以上,能够用英语交流,并已脱离服务至少三个月。服务使用者和照顾者参与者的招募和面试过程独立进行。潜在参与者被邀请通过视频电话或亲自参加面对面的半结构化访谈。每次访谈时间为一至两小时,包括五个阶段--破冰、探讨参与者决定脱离 EPIP 前的经历、讨论脱离原因、探讨脱离后的经历以及对 EPIP 的反馈和建议。招募工作的目标是在对服务使用者和护理人员两组的 10-15 名参与者进行访谈后结束,预计在没有产生新主题的情况下达到数据充足:最终招募了 12 名服务使用者和 12 名护理人员。其中有六对服务使用者和护理者组合,接受访谈的护理者同时也在护理参与研究的服务使用者。我们收集到了宝贵的定性信息,包括脱离的类型、脱离期间的用药依从性、脱离背后的决策过程以及重新参与的相关情况。从服务使用者脱离服务的原因中,共确定了五个类别,每个类别都有副主题--个人因素、污名化、进展、治疗因素和外部因素:有必要缩小亟需关注的领域,将研究主题与既定的风险因素相统一,从而制定可行的解决方案并采用适当的护理模式,最大限度地减少与脱离服务相关的不良后果。重要的是要保持开放的心态,了解个人康复对服务使用者的意义,从而更好地协调治疗目标。
{"title":"Reasons for disengagement in first-episode psychosis - perspectives from service users and their caregivers.","authors":"Yi Chian Chua, Kumarasan Roystonn, K Pushpa, Swapna Verma, Charmaine Tang","doi":"10.1186/s12888-024-06190-4","DOIUrl":"10.1186/s12888-024-06190-4","url":null,"abstract":"<p><strong>Background: </strong>The efforts of early psychosis intervention programmes can be impeded by difficulties in maintaining the engagement of service users. As disengagement is often an autonomous decision made by service users, the main aim of this study was to gain insight into the reasons for service user disengagement through qualitative interviews with the service users themselves, and caregivers as proxies or secondary informants.</p><p><strong>Methods: </strong>Participants recruited for the study were enrolled in the Early Psychosis Intervention Programme in Singapore for at least a year, aged 21 and above, able to communicate in English, and had disengaged for at least three months. The recruitment and interview processes were conducted independently for service user and caregiver participants. Potential participants were invited to a face-to-face semi-structured interview over video call or in-person. Each interview spanned one to two hours, and comprised five phases - icebreaker, exploration of the participant's experience with EPIP before deciding to disengage, discussion of reasons for disengagement, exploration of the post-disengagement experience, and feedback and suggestions for EPIP. Recruitment aimed to conclude after 10-15 participants were interviewed for both service user and caregiver groups, with the expectation that data sufficiency would be reached with no new themes being generated.</p><p><strong>Results: </strong>Ultimately, 12 service user and 12 caregiver participants were recruited. There were six pairs of service user and caregiver dyads, where the caregivers interviewed were caring for service users also enrolled in the study. Valuable qualitative insights were gathered, including the type of disengagement, medication compliance during disengagement, the decision-making process behind disengaging, and circumstances surrounding re-engagement. A total of five categories each with subthemes were identified from the reasons for service user disengagement - individual factors, stigma, progression, treatment factors, and external factors.</p><p><strong>Conclusions: </strong>There is a need to narrow down urgent areas of attention, aligning the study themes with established risk factors so that feasible solutions can be developed and appropriate care models can be adopted, to minimise adverse outcomes related to disengagement. It is important to keep an open mind to understand what personal recovery means to the individual service user, so that treatment goals can be better harmonised.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"788"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimated glucose disposal rate is correlated with increased depression: a population-based study. 估计葡萄糖排出率与抑郁症增加相关:一项基于人群的研究。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-11 DOI: 10.1186/s12888-024-06257-2
Yuanyuan Chen, Hao Lin, Jing Xu, Xinhe Zhou

Background: Recent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population.

Methods: In this population-based cross-sectional study, data from 28,444 adults aged 18 years old or older in the NHANES during the period from 1999 to 2018 were analyzed. The correlation between eGDR and depression was examined through multivariate logistic regression analyses, subgroup analyses, restricted cubic spline, and interaction tests. Furthermore, a mediation analysis was conducted to elucidate the role of the atherogenic index of plasma (AIP) in mediating the effect of eGDR on depression.

Results: Multivariate logistic regression analysis and restricted cubic splines analysis indicated that eGDR can exhibit a linearly correlation with depression (OR = 0.913; 95% CI: 0.875, 0.953). Subjects in eGDR6-8 and eGDR > 8 groups had a decrease risk of depression as 25.4% and 41.5% than those in the eGDR < 4 group. This negative correlation was more pronounced in those with obesity. Mediation analysis indicated that AIP mediated 9.6% of the correlation between eGDR and depression.

Conclusions: eGDR was linear negatively correlated with depression, with AIP playing a mediating role. This study provides a novel perspective on the mechanism connecting IR to depression. Managing IR and monitoring AIP may contribute to alleviating depression.

背景:最近的研究发现,胰岛素抵抗(IR)与抑郁症之间存在相关性。本研究旨在探讨普通人群中估计葡萄糖排泄率(eGDR)与抑郁症之间的相关性:在这项基于人群的横断面研究中,我们分析了 1999 年至 2018 年期间参加 NHANES 的 28,444 名 18 岁或以上成年人的数据。通过多变量逻辑回归分析、亚组分析、限制性三次样条和交互检验,研究了 eGDR 与抑郁症之间的相关性。此外,还进行了中介分析,以阐明血浆致动脉粥样硬化指数(AIP)在调解 eGDR 对抑郁症影响中的作用:结果:多变量逻辑回归分析和限制性三次样条分析表明,eGDR与抑郁症呈线性相关(OR = 0.913; 95% CI: 0.875, 0.953)。结论:eGDR 与抑郁症呈线性负相关,AIP 起中介作用。这项研究为了解 IR 与抑郁症的关联机制提供了一个新的视角。管理 IR 和监控 AIP 可能有助于缓解抑郁。
{"title":"Estimated glucose disposal rate is correlated with increased depression: a population-based study.","authors":"Yuanyuan Chen, Hao Lin, Jing Xu, Xinhe Zhou","doi":"10.1186/s12888-024-06257-2","DOIUrl":"10.1186/s12888-024-06257-2","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population.</p><p><strong>Methods: </strong>In this population-based cross-sectional study, data from 28,444 adults aged 18 years old or older in the NHANES during the period from 1999 to 2018 were analyzed. The correlation between eGDR and depression was examined through multivariate logistic regression analyses, subgroup analyses, restricted cubic spline, and interaction tests. Furthermore, a mediation analysis was conducted to elucidate the role of the atherogenic index of plasma (AIP) in mediating the effect of eGDR on depression.</p><p><strong>Results: </strong>Multivariate logistic regression analysis and restricted cubic splines analysis indicated that eGDR can exhibit a linearly correlation with depression (OR = 0.913; 95% CI: 0.875, 0.953). Subjects in eGDR6-8 and eGDR > 8 groups had a decrease risk of depression as 25.4% and 41.5% than those in the eGDR < 4 group. This negative correlation was more pronounced in those with obesity. Mediation analysis indicated that AIP mediated 9.6% of the correlation between eGDR and depression.</p><p><strong>Conclusions: </strong>eGDR was linear negatively correlated with depression, with AIP playing a mediating role. This study provides a novel perspective on the mechanism connecting IR to depression. Managing IR and monitoring AIP may contribute to alleviating depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"786"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-naïve major depressive disorder patients with comorbid metabolic syndrome. 合并代谢综合征的重度抑郁症初发患者和未服药患者自杀未遂的临床特征和影响因素的性别差异。
IF 3.4 2区 医学 Q2 PSYCHIATRY Pub Date : 2024-11-11 DOI: 10.1186/s12888-024-06256-3
Ping Sun, Yingying Huang, Hui Yu, Xiaohui Wu, Jun Chen, Yiru Fang, Xiangyang Zhang

Backgrounds: Patients with major depressive disorder (MDD) have a high rate of metabolic syndrome (MetS), which could worsen disease progression. One of the most serious progressions in MDD is suicide attempts (SAs). Previous studies have found gender differences in MetS and SAs among MDD patients respectively. Therefore, we aimed to explore gender differences of SAs in first-episode and drug-naïve (FEDN) MDD patients with comorbid MetS.

Methods: 1718 outpatients with FEDN MDD were recruited. Depression, anxiety and psychotic symptoms were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Blood sugar, blood fat, blood pressure and body mass index (BMI) were measured to evaluate MetS.

Results: 34.4% patients with FEDN MDD were diagnosed as MetS and those subjects with or without MetS differed in the distribution of SAs and gender. In MetS subgroup, 29.5% and 29.7% of male and female subjects had SAs respectively, without significant differences. However, compared with non-suicide attempters, suicide attempters had higher level of blood pressure in female subjects, while there are no differences in any clinical variables in male subjects. Additionally, the influencing factors for SAs differed by gender. The HAMA scores and BMI were variables associated with SAs in male patients while HAMA scores, marital status and systolic blood pressure (SBP) were associated with SAs in female patients. Furthermore, the receiver operating characteristics (ROC) curves, demonstrating the combination all influencing factors by gender, showed good performance and model accuracy.

Conclusions: In FEDN MDD patients with comorbid MetS, there were no gender differences in SAs. However, clinical characteristics and influencing factors of SAs differed in different gender groups.

背景:重度抑郁障碍(MDD)患者的代谢综合征(MetS)发病率很高,这可能会导致病情恶化。自杀企图(SAs)是重度抑郁症最严重的进展之一。以往的研究发现,MDD 患者的 MetS 和 SAs 分别存在性别差异。因此,我们旨在探讨合并 MetS 的首次发病且未服药(FEDN)MDD 患者的 SAs 性别差异。分别使用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和阳性与阴性综合征量表(PANSS)阳性分量表评估抑郁、焦虑和精神病性症状。测量血糖、血脂、血压和体重指数(BMI)以评估 MetS:34.4%的FEDN MDD患者被诊断为MetS,有无MetS的受试者在SA的分布和性别上存在差异。在MetS亚组中,分别有29.5%和29.7%的男性和女性受试者有自杀倾向,且无显著差异。然而,与非自杀企图者相比,女性自杀企图者的血压水平较高,而男性自杀企图者的任何临床变量均无差异。此外,自杀倾向的影响因素也因性别而异。男性患者的 HAMA 评分和体重指数(BMI)与自杀相关,而女性患者的 HAMA 评分、婚姻状况和收缩压(SBP)与自杀相关。此外,接收器操作特征曲线(ROC)显示了按性别划分的所有影响因素的组合,显示了良好的性能和模型的准确性:结论:在合并 MetS 的 FEDN MDD 患者中,SAs 没有性别差异。然而,不同性别组的临床特征和SAs影响因素存在差异。
{"title":"Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-naïve major depressive disorder patients with comorbid metabolic syndrome.","authors":"Ping Sun, Yingying Huang, Hui Yu, Xiaohui Wu, Jun Chen, Yiru Fang, Xiangyang Zhang","doi":"10.1186/s12888-024-06256-3","DOIUrl":"10.1186/s12888-024-06256-3","url":null,"abstract":"<p><strong>Backgrounds: </strong>Patients with major depressive disorder (MDD) have a high rate of metabolic syndrome (MetS), which could worsen disease progression. One of the most serious progressions in MDD is suicide attempts (SAs). Previous studies have found gender differences in MetS and SAs among MDD patients respectively. Therefore, we aimed to explore gender differences of SAs in first-episode and drug-naïve (FEDN) MDD patients with comorbid MetS.</p><p><strong>Methods: </strong>1718 outpatients with FEDN MDD were recruited. Depression, anxiety and psychotic symptoms were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Blood sugar, blood fat, blood pressure and body mass index (BMI) were measured to evaluate MetS.</p><p><strong>Results: </strong>34.4% patients with FEDN MDD were diagnosed as MetS and those subjects with or without MetS differed in the distribution of SAs and gender. In MetS subgroup, 29.5% and 29.7% of male and female subjects had SAs respectively, without significant differences. However, compared with non-suicide attempters, suicide attempters had higher level of blood pressure in female subjects, while there are no differences in any clinical variables in male subjects. Additionally, the influencing factors for SAs differed by gender. The HAMA scores and BMI were variables associated with SAs in male patients while HAMA scores, marital status and systolic blood pressure (SBP) were associated with SAs in female patients. Furthermore, the receiver operating characteristics (ROC) curves, demonstrating the combination all influencing factors by gender, showed good performance and model accuracy.</p><p><strong>Conclusions: </strong>In FEDN MDD patients with comorbid MetS, there were no gender differences in SAs. However, clinical characteristics and influencing factors of SAs differed in different gender groups.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"789"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BMC Psychiatry
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1