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Tyrosine Kinase Inhibitors and Thyroid Toxicity 酪氨酸激酶抑制剂和甲状腺毒性
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2713
Stefano Mastrangelo, Giorgio Attina, Antonio Ruggiero
Some multithyrosine kinase inhibitors have been reported to cause changes in thyroid function. For the management of sunitinib-induced hypothyroidism, an evaluation of thyroid hormone and antibody profile is recommended before starting treatment with tyrosine kinase inhibitors. Patients with pre-existing thyroid dysfunction should undergo dose adjustment of L-thyroxine during treatment with tyrosine kinase inhibitors. Thyroid dysfunction is not a reason to discontinue or reduce the dosage of sunitinib. Their occurrence appears to correlate with increased antitumour efficacy of the inhibitor. There are currently no guidelines for monitoring thyroid activity during treatment with TKIs, and the time interval at which TSH should be periodically measured has not yet been determined. A reasonable approach is to monitor thyroid function, both before and during 2-4 weeks after the end of therapy. A comprehensive analysis of adverse events associated with the use of these inhibitors could help clinical monitoring of patients along with the adoption of appropriate management approaches.
一些多甲状腺氨酸激酶抑制剂已被报道引起甲状腺功能的改变。对于舒尼替尼引起的甲状腺功能减退的治疗,建议在开始酪氨酸激酶抑制剂治疗之前评估甲状腺激素和抗体谱。已有甲状腺功能障碍的患者在使用酪氨酸激酶抑制剂治疗期间应调整l -甲状腺素的剂量。甲状腺功能障碍不是停止或减少舒尼替尼剂量的原因。它们的发生似乎与抑制剂抗肿瘤功效的增加有关。目前还没有TKIs治疗期间监测甲状腺活动的指南,TSH应定期测量的时间间隔也尚未确定。一个合理的方法是在治疗结束前和治疗结束后2-4周监测甲状腺功能。与使用这些抑制剂相关的不良事件的综合分析可以帮助患者的临床监测以及采取适当的管理方法。
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引用次数: 0
Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats 石榴皮提取物和左旋肉碱对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2762
Anwar M. M. Ezz, Omar N. ALheeti, Ahmed F. Hasan, Somaia Zaki, Ghada A. Tabl
Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats.
2型糖尿病是一种影响深远的持续代谢问题,由高血糖引起,并与高脂血症等并发症有关。本研究旨在研究石榴皮提取物和左旋肉碱对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。将70只雄性大鼠分为7组(正常大鼠给予石榴皮提取物和左旋肉碱;高脂饮食引起高脂血症的大鼠,腹腔注射低剂量链脲佐菌素引起II型糖尿病的大鼠;糖尿病大鼠每天口服PPE和左旋肉碱,连续12周。测量了体重、血糖、血脂和抗氧化酶活性。结果:PPE +左旋肉碱治疗组患者体重明显下降,血糖、胆固醇、甘油三酯、低密度脂蛋白明显降低,高密度脂蛋白水平明显升高。PPE和左旋肉碱使糖尿病大鼠超氧化物歧化酶、过氧化氢酶和核因子红系衍生2 (Nfe2)水平升高,丙二醛水平显著降低。根据研究结果,PPE和左旋肉碱在链脲佐菌素诱导的糖尿病大鼠治疗12周后具有显著的降糖、降血脂和抗氧化作用。
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引用次数: 0
Weakening of Virulence Factors and Biofilm in Salmonella Typhi by Medicinal Plants Extracts 药用植物提取物对伤寒沙门菌毒力因子和生物膜的削弱作用
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2740
Akhter Ahmed Ahmed, Pakhshan Abdulla Hassan, Abdulilah Saleh Ismaeil, Shahnaz Burhan Ali
Objective(s): Salmonella typhi, is a serious global health threat because it causes typhoid fever, a severe systemic infection. According to the World Health Organization, millions of cases of typhoid are recorded annually, and thousands of people die from it. To combat this pathogen, new medications are required. The current study aims to study the ability of medicinal plants (thyme and cinnamon) to modulate the properties of Salmonella typhi isolates instead of killing them. Materials and Methods: The plants were extracted with the help of solvents (ethanol and ethyl acetate) and to find out the minimum inhibitory concentration, the different concentrations were used. The biofilm and expression of genes (invA & fliC) of the bacterium were studied when exposed to sub-inhibitory concentrations of the plant extracts. Results: MIC values ranging between 20-25 mg/ml and 10-15 mg/ml for ethanol and ethyl acetate extracts of Thyme respectively. While the MIC values of cinnamon were 18-25 and 10-15 mg/ml for both ethanol and ethyl acetate extracts respectively. The examinations revealed a significant decrease in the composition of biofilms by isolates when treated with SICs from plant extracts. The transcription expression profile of invasion (invA) and flagellar (fliC) genes were downregulated when treated with the plant extracts. Conclusion: The findings indicate that both thyme and cinnamon extracts may have promising activity against the biofilm and virulence of S. typhi. Thus, they could be used as potential as an antibacterial drug.
目的:伤寒沙门氏菌是一种严重的全球健康威胁,因为它会引起伤寒,一种严重的全身感染。根据世界卫生组织的数据,每年有数百万例伤寒病例被记录在案,数千人死于伤寒。为了对抗这种病原体,需要新的药物。目前的研究旨在研究药用植物(百里香和肉桂)调节伤寒沙门氏菌分离株的特性而不是杀死它们的能力。材料与方法:以乙醇和乙酸乙酯为溶剂,通过不同的提取浓度,确定其最低抑菌浓度。基因(invA &当暴露于亚抑制浓度的植物提取物时,研究了细菌的fliC。结果:百里香乙醇提取物和乙酸乙酯提取物的MIC值分别为20 ~ 25 mg/ml和10 ~ 15 mg/ml。乙醇和乙酸乙酯提取物对肉桂的MIC值分别为18 ~ 25和10 ~ 15 mg/ml。检测结果显示,用植物提取物中的无机化学物质处理后,分离物的生物膜组成显著减少。侵染基因(invA)和鞭毛基因(fliC)的转录表达谱在植物提取物处理下下调。结论:百里香和肉桂提取物对伤寒沙门氏菌的生物膜和毒力均有较好的抑制作用。因此,它们有可能被用作抗菌药物。
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引用次数: 0
In silico Study of Phenol Explorer Database as Potential Inhibitors of Quorum-Sensing Regulated Pathogenicity in Pseudomonas aeruginosa 苯酚探索者数据库作为群体感应调节铜绿假单胞菌致病性潜在抑制剂的计算机研究
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2736
Arnica F Lal, Pushpraj S Gupta, Pramod Kumar Yadav
Immunocompromised patients get Pseudomonas aeruginosa infections. P. aeruginosa's harmful effect is linked to quorum sensing (QS), which causes bacterial biofilm. Targeting QS is a promising novel method to treat P. aeruginosa infections, which are antibiotic-resistant. The Las system has garnered great interest due to LasR, the expedited gene during QS that regulates other virulence-associated genes. We used high-throughput virtual screening (VS) of Phenol Explorer to uncover a new category of LasR inhibitors that might be used as antagonists. Molecular docking-based VS against LasR (PDB: 2UV0) resulted in six best-scored compounds: Chrysin, Galangin, Coumestrol, 3',4',7- Trihydroxyisoflavanone, Dihydrodaidzein, Dihydroformononetin with docking score of -11.0 kcal/mol and a suitable ADMET profile. Six compounds were chosen for their lack of carcinogenicity in mice and rats, low molecular weight of 270 Da, and moderate to total solubility. Our current work shows that these six chemicals could block P. aeruginosa quorum sensing. Molecular dynamics investigations of a prospective therapeutic candidate (Chrysin) using Gromacs version 2022.2 demonstrated system stability; nonetheless, the antibiofilm assay showed a positive reaction against our in silico finding, suggesting a disturbance in quorum sensing regulating pathogenicity, i.e., biofilm formation. This study is the first to describe chrysin as a disruptor of quorum sensing signaling by inhibiting biofilm formation.
免疫功能低下的患者会感染铜绿假单胞菌。铜绿假单胞菌的有害影响与群体感应(QS)有关,它会导致细菌生物膜。靶向QS是治疗耐药铜绿假单胞菌感染的一种很有前景的新方法。LasR是QS过程中的加速基因,可以调节其他毒力相关基因,因此LasR系统引起了人们的极大兴趣。我们利用苯酚探索者的高通量虚拟筛选(VS)发现了一类可能用作拮抗剂的新型激光受体抑制剂。基于分子对接的LasR VS (PDB: 2UV0)得到6个得分最高的化合物:黄菊花素、高良姜素、库美斯特罗、3′,4′,7-三羟基异黄酮酮、二氢大豆苷元、二氢formononatin,对接得分为-11.0 kcal/mol,符合ADMET谱。选择的6种化合物对小鼠和大鼠没有致癌性,低分子量为270 Da,溶解度中等至全溶解度。我们目前的工作表明,这六种化学物质可以阻断铜绿假单胞菌的群体感应。使用Gromacs version 2022.2对一种前瞻性候选治疗药物(Chrysin)进行分子动力学研究,证明了系统的稳定性;尽管如此,抗生物膜实验显示出对我们的硅发现的阳性反应,这表明群体感应的干扰调节致病性,即生物膜的形成。这项研究是第一个描述菊素作为群体感应信号的干扰物通过抑制生物膜的形成。
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引用次数: 0
Quality by Design Approach: Progress in Pharmaceutical method Development and Validation 设计质量:制药方法开发和验证的进展
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2745
Avinash V. Chavan, R. Gandhimathi
Pharmaceutical analysis plays a significant role in pharmaceutical formulation quality assurance and control. Due to the pharmaceutical industries' rapid expansion and the production of pharmaceuticals all over the world, there is a greater need for novel analytical procedures in this sector. Establishing the identification, purity, physical properties, and potency of medications as well as the medication's bioavailability and stability is the goal of analytical method development. A few new drug applications were recently given regulatory flexibility by the Food and Drug Administration for an analytical method based on quality by design. With Quality by design, product design and development are performed methodically. Analytical methodologies have similar opportunities for implementing Quality by design as production procedures do. It consequently enhances formulation design, development efficiency, and capacity. The underpinnings of the QbD approach have been explored in this article due to their use in the creation and validation of analytical procedures. Additionally, a summary of experimental studies reporting the application of the QbD methodology to method development is included.
药物分析在药物制剂质量保证和控制中起着重要的作用。由于制药工业的快速扩张和世界各地药品的生产,这一领域对新型分析方法的需求更大。建立药物的鉴定、纯度、物理性质和效力以及药物的生物利用度和稳定性是分析方法发展的目标。最近,美国食品和药物管理局对基于质量设计的分析方法给予了一些新药申请监管灵活性。通过设计实现质量,有条不紊地进行产品设计和开发。分析方法与生产程序一样,有类似的机会通过设计实现质量。因此,它提高了配方设计、开发效率和能力。本文探讨了QbD方法的基础,因为它们用于创建和验证分析过程。此外,还包括报告QbD方法在方法开发中的应用的实验研究摘要。
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引用次数: 1
Health Literacy in People Living with Human Immunodeficiency Virus Infection: A Narrative Review 人类免疫缺陷病毒感染者的健康素养:一个叙述性的回顾
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2726
Basavaraj Poojar, Ashok Shenoy K, Ashwin Kamath, John Ramapuram, Sathish B. Rao, Sheetal Dinkar Ullal
Overall literacy talents comprise an individual’s capacity to read, write and recognise written information (print literacy), articulate and interpret oral language (oral literacy) and interpret and apply for numbers in everyday activities (numeracy). Health literacy, a subset of overall literacy talents, is relatively correlated with it and has been described as the extent to which people can gain, approach, and understand introductory medical information and services required to take health decisions. Concerning HIV, people with low health literacy have less information on the illness and their medical care needs. Moreover, they show poor drug compliance, potentially leading to treatment failure and lack of achievement of the target viral load reduction. The shortfall of non-conceptual models of health literacy is an issue in the utilization of general proficiency instruments. HIV disease-specific health literacy instruments would be more useful and likely to provide more meaningful results rather than those obtained through the use of general instruments. Further exploration of HIV health literacy is demanded. Prospective studies should involve different geographical areas with different socioeconomic characteristics, societal structures and regional healthcare settings. This narrative review has limitations. The vast majority of the HIV research referenced in this study was conducted among the western and African populations with HIV. The studies generally excluded individuals over 50 years of age, restricting the applicability of the study findings.
全面的读写能力包括个人阅读、写作和识别书面信息的能力(印刷素养),表达和解释口头语言的能力(口头素养),以及在日常活动中解释和应用数字的能力(算术能力)。健康素养是整体素养的一个子集,与健康素养相对相关,并被描述为人们能够获得、接近和理解做出健康决策所需的介绍性医疗信息和服务的程度。关于艾滋病毒,卫生知识普及程度低的人对这种疾病及其医疗保健需求的了解较少。此外,它们表现出较差的药物依从性,可能导致治疗失败和缺乏目标病毒载量降低的实现。缺乏卫生知识普及的非概念性模型是利用一般熟练程度工具的一个问题。针对艾滋病毒疾病的卫生扫盲工具比通过使用一般工具获得的结果更有用,也可能提供更有意义的结果。需要进一步探索艾滋病毒健康素养。前瞻性研究应涉及具有不同社会经济特征、社会结构和区域卫生保健设置的不同地理区域。这种叙事回顾有其局限性。本研究中引用的绝大多数艾滋病毒研究都是在西非和非洲艾滋病毒感染者中进行的。这些研究一般排除了50岁以上的个体,限制了研究结果的适用性。
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引用次数: 0
In Vivo and In Vitro Antidiabetic Assay of Purified Mahoni Seeds Extract (Swietenia mahagoni (L.) Jacq) Mahoni种子提取物体内外抗糖尿病实验研究Jacq)
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2748
Aktsar Roskiana Ahamd, Abd. Malik, Virsa Handayani
This study examined the future of Mahoni seed as an aspirant drug for treating diabetes. Mahogany seeds were washed using n-hexane solvent and followed by ethanol solvent. Extracts were measured using a standard spectrophotometric plate reader with acarbose (Glucobayâ). Glucose tolerance was tested in alloxan-challenged mice. The results indicated that the extract had potency against a-glucosidases inhibited through a non-competitive mechanism. The IC50 value of the extract is 4.7 μg/ml, which was lower than 5.7 μg/ml for acarbose and has less activity on glucose tolerance at doses of 120 and 240 mg/kg. As a conclution, purified mahogany seed extract got the ability to be developed as a new antidiabetic drug candidate.
这项研究考察了马霍尼种子作为治疗糖尿病的药物的前景。红木种子先用正己烷洗涤,再用乙醇洗涤。提取液采用标准分光光度计,用阿卡波糖(glucobay)测定。在四氧嘧啶刺激小鼠中测试葡萄糖耐量。结果表明,该提取物对a-葡萄糖苷酶具有非竞争性抑制作用。120和240 mg/kg剂量下,提取物的IC50值为4.7 μg/ml,低于阿卡波糖的IC50值5.7 μg/ml,对糖耐量的影响较小。综上所述,纯化红木籽提取物具有开发新型抗糖尿病药物的潜力。
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引用次数: 0
The Effect of Administering Forest Honey to Rats Exposed to Physical Stress on Corticosteroid Levels, Folliculogenesis and the Number of Corpus Luteum 给药森林蜂蜜对应激大鼠皮质类固醇水平、卵泡发生和黄体数量的影响
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2721
Widjiati Widjiati, Suryo Kuntjorodjakti, Aditya Tri Ananda, Mey Vanda Pusparina Sajida, Alivia Fairuz Ilmi, Meisa Zalfa Adisti, Dean Chou, Epy Muhammad Luqman
Livestock that has stress releases glucocorticoids in response to it, and it causes inhibition of the hypothalamus-pituitary-gonadal axis (HPG) signaling pathway so that it reduces reproductive efficiency. Forest honey can reduce corticosteroid levels as a stress response from physical stress induction which is expected to increase reproductive efficiency including folliculogenesis and the formation of the corpus luteum. This study aims to determine the effect of forest honey on rats (Rattus novergicus) exposed to physical stress on corticosteroid levels, folliculogenesis, and the number of corpus luteum. This study is an experimental laboratory one using 32 rats which were divided into 4 treatment groups; control positive (C) treated with physical stress, treatment 1 (T1) treated with physical stress + honey 2 g/rat/day PO, treatment 2 (T2) treated with physical stress + honey 4 g/rat/day PO and treatment 3 (T3) treated with physical stress + honey 6 g/rat/day PO. All treatments were carried out for 14 days. The results showed that T1 had the lowest corticosteroid level compared to all treatment groups and the corticosteroid level of this group was significantly different (p <0.05) compared to that of C and T3. The folliculogenesis profile showed that the number of primary secondary, tertiary, and Graafian follicles of group T1 was significantly different (p<0.05) compared to that of C, T2, and T3. In terms of the number of corpus luteum, it showed that T1 had the highest number of corpus luteum, and the number of corpus luteum in this group was significantly different (p<0.05) from that of C, T2, and T3. It can be concluded that the administration of forest honey at a dose of 2g/rat/day could reduce corticosteroid levels, improve the folliculogenesis profile, and increase the number of corpus luteum in rats exposed to physical stress. The use of forest honey could reduce corticosteroid levels as a stress response from physical stress induction which was expected to increase reproductive efficiency.
牲畜在应激状态下会释放糖皮质激素,从而抑制下丘脑-垂体-性腺轴(HPG)信号通路,从而降低繁殖效率。森林蜂蜜可以降低糖皮质激素水平,作为生理应激诱导的应激反应,这有望提高生殖效率,包括卵泡发生和黄体的形成。本研究旨在确定森林蜂蜜对身体应激大鼠(Rattus novergicus)皮质类固醇水平、卵泡发生和黄体数量的影响。本研究为实验室实验,32只大鼠分为4个治疗组;对照阳性(C)组为物理应激组,处理1 (T1)组为物理应激+蜂蜜2 g/大鼠/天PO,处理2 (T2)组为物理应激+蜂蜜4 g/大鼠/天PO,处理3 (T3)组为物理应激+蜂蜜6 g/大鼠/天PO。所有治疗均进行14 d。结果显示,T1组皮质激素水平较各治疗组最低,且与C组和T3组相比,T1组皮质激素水平差异有统计学意义(p <0.05)。与C、T2和T3组相比,T1组的初级、次级、三级和Graafian卵泡数量有显著差异(p < 0.05)。黄体数量方面,T1组黄体数量最多,与C、T2、T3组黄体数量差异有统计学意义(p < 0.05)。由此可见,森林蜂蜜剂量为2g/大鼠/d,可降低应激大鼠体内皮质激素水平,改善卵泡发生状况,增加黄体数量。使用森林蜂蜜可以降低糖皮质激素水平,作为生理应激诱导的应激反应,有望提高生殖效率。
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引用次数: 0
Vitis Pedata Nanoformulation in the Management of Alloxan Induced Experimental Diabetes Vitis Pedata纳米制剂在四氧嘧啶诱导的实验性糖尿病治疗中的应用
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2715
Suvadra Das, Joyeeta Bhattacharya, Srija Sur, Subhasis Chakraborty, Aparna Lakshmi, Tanay Pramanik, Partha Roy
Vitis pedata is a woody climber of the Vitaceae family with a multitude of pharmacological effects like anti-inflammatory, antibacterial, anti-nociceptive, anti-arthritic, anti-oxidant, astringent, and hemostatic qualities. The research targets to assess the anti-diabetic efficacy of Vitis pedata aqueous extract nanoformulation in alloxan-induced diabetes rats. Biocompatible polycationic polymer chitosan is used for nanoformulation development. The aqueous extract loaded chitosan nanoparticle formulation displayed a particle size of 186± 5.37 nm with a polydispersity index of 0.226 and zeta potential value of 23 ± 1.93 mV. The nanoformulations were assessed for its anti-diabetic properties in comparison to aqueous extracts for the first time by in- vivo methodologies. Several parameters like body weight, blood glucose level, blood and serum biomarkers, were examined. Changes in tissue histoarchitecture, liver glycogen content, oxidative stress response and antioxidant status were also studied. In diabetic rats, the nano-scale formulation significantly reduced blood glucose levels, glucose tolerance, lipid profiles, and serum biomarkers, comparable to the oral hypoglycemic medication glibenclamide. The restoration of antioxidant status and pancreatic histoarchitecture through by size assisted delivery may be related to the improved control of diabetes by the nanoformulation than the extract alone. The work marks the first report of Vitis pedata nanoformulation for diabetes management and can serve as a prelude for further preclinical/clinical evaluations.
葡萄是一种藤本植物,具有多种药理作用,如抗炎、抗菌、抗伤害、抗关节炎、抗氧化、收敛和止血。研究目的是评价葡萄水提物纳米制剂对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病作用。利用生物相容性聚阳离子聚合物壳聚糖进行纳米配方的研制。水提物负载壳聚糖纳米颗粒的粒径为186±5.37 nm,多分散指数为0.226,zeta电位值为23±1.93 mV。该纳米制剂的抗糖尿病特性首次通过体内方法与水提取物进行了比较。研究人员检查了一些参数,如体重、血糖水平、血液和血清生物标志物。研究了组织结构、肝糖原含量、氧化应激反应和抗氧化状态的变化。在糖尿病大鼠中,纳米级制剂显著降低血糖水平、葡萄糖耐量、脂质谱和血清生物标志物,与口服降糖药格列本脲相当。通过大小辅助分娩恢复抗氧化状态和胰腺组织结构可能与纳米配方比单独提取物改善糖尿病控制有关。这项工作标志着Vitis pedata纳米配方用于糖尿病管理的第一份报告,可以作为进一步临床前/临床评估的前奏。
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引用次数: 0
Relationship between Cardiovascular Risk Factors and Development of Acute Coronary Syndrome 心血管危险因素与急性冠脉综合征发生的关系
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-30 DOI: 10.13005/bpj/2756
Tahani H Ibrahim, Sara Almutiri, Manahil Alharbi, Dana Alotaibi, Mehboob Ali, Waleed Hamza, Mohamed Zaki
Acute coronary syndrome (ACS) which known as subcategory of coronary heart disease is considered a major cause of death. In Saudi Arabia, the prevalence of ACS is 8.2%. Early recognition of risk factors (RFs) associated with ACS is essential to prevent its progression. Therefore, the goals of this study is to estimate the prevalence of cardiovascular RFs among ACS patients and to appraise its association with the development of ACS. This retrospective multi-center cross-sectional study involved 170 patients admitted to Prince Sultan cardiac center, King Saud Hospital, and Bukayriyah General Hospital in Al Qassim, KSA. The participants categorized into three groups UA, NSTEMI, and STEMI. Patients with stable angina or previous MI were excluded from the study. 73.5% were males and 26.5% were females with a mean age of 58.2 ± 11.9. The distribution of ACS subtypes was 51.2%, 27.6%, and 21.2% for STEMI, NSTEMI and UA, respectively. The most common RFs were diabetes mellitus (DM), hypertension (66% each), and dyslipidemia (58%). The prevalence of RFs among STEMI group was 65.6% active smokers, 54.5% dyslipidemia, and 52.2% ischemic heart disease (IHD). On the other hand, in NSTEMI group hypertension and DM were nearly the same (32% & 30% respectively), however family history of IHD was 42.9%. UA revealed a strong association with IHD and family history of IHD (30.4%, 28.6%, respectively).To conclude, most of ACS patients presented with STEMI followed by NSTEMI and the least with UA. Among the cardiovascular risk factors, HTN, DM, and dyslipidemia, were presented in more than half of the patients which strongly suggests an association with developing ACS.
急性冠状动脉综合征(ACS)被认为是冠心病的一个亚类,是导致死亡的主要原因。在沙特阿拉伯,ACS患病率为8.2%。早期识别与ACS相关的危险因素(RFs)对于预防其进展至关重要。因此,本研究的目的是估计ACS患者中心血管RFs的患病率,并评估其与ACS发展的关系。这项回顾性多中心横断面研究纳入了沙特阿拉伯Al Qassim的苏尔坦王子心脏中心、沙特国王医院和Bukayriyah总医院的170例患者。参与者分为UA、NSTEMI和STEMI三组。有稳定型心绞痛或既往心肌梗死的患者被排除在研究之外。男性占73.5%,女性占26.5%,平均年龄58.2±11.9岁。STEMI、NSTEMI和UA的ACS亚型分布分别为51.2%、27.6%和21.2%。最常见的RFs是糖尿病(DM)、高血压(各66%)和血脂异常(58%)。STEMI组中RFs患病率为:活跃吸烟者65.6%,血脂异常54.5%,缺血性心脏病(IHD) 52.2%。另一方面,在NSTEMI组高血压和糖尿病几乎相同(32% &30%),家族史占42.9%。UA与IHD和IHD家族史密切相关(分别为30.4%和28.6%)。综上所述,大多数ACS患者以STEMI为主,其次为NSTEMI,最少为UA。在心血管危险因素中,超过一半的患者出现HTN、DM和血脂异常,这强烈提示与ACS的发生有关。
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引用次数: 0
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Biomedical and Pharmacology Journal
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