BMC Ophthalmology最新文献

Objective: This study aimed to investigate the relationship between systemic fibrosis markers, including the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) and the Fibrosis-4 Index (FIB-4), and the development of proliferative vitreoretinopathy (PVR).

Methods: The medical records of patients who underwent surgery for rhegmatogenous retinal detachment between January 2019 and October 2025 were retrospectively reviewed. A total of 394 participants were included and divided into three groups: PVR-positive retinal detachment group (PVR (+) RD; n = 150), PVR-negative retinal detachment group (PVR (-) RD; n = 175), and a healthy control group (n = 69). APRI and FIB-4 scores were calculated using preoperative complete blood count and liver function test parameters. Demographic data and clinical characteristics of the patients were recorded.

Results: The mean age of the 394 participants included in the study was 59.9 ± 13.2 years (range: 22-89 years). Of the patients, 184 (46.7%) were female, and 210 (53.3%) were male. Although the mean FIB-4 and APRI values tended to be higher in the PVR (+) group compared with the PVR (-) and control groups, no statistically significant differences were observed (p = 0.062 and p = 0.835, respectively). In multivariate logistic regression analysis, longer symptom duration was independently associated with an increased risk of proliferative vitreoretinopathy (OR = 1.04, 95% CI: 1.02-1.06; p = 0.001). Diabetes mellitus was also identified as an independent risk factor for PVR development (OR = 2.51, 95% CI: 1.22-5.17; p = 0.013), and inferior rhegmatogenous retinal detachment was significantly associated with PVR (OR = 0.48, 95% CI: 0.25-0.93; p = 0.029).

Conclusion: The APRI and FIB-4 indices did not reveal a statistically significant difference in distinguishing the development of proliferative vitreoretinopathy. These findings support that the pathogenesis of PVR is primarily driven by inflammatory and fibroproliferative processes occurring within the local vitreoretinal microenvironment rather than by systemic fibrosis.

Purpose: To describe the clinical characteristics and visual and anatomical surgical prognosis for full-thickness macular hole (FTMH) secondary to retinal vein occlusion (RVO).

Method: This retrospective study reviewed 13 eyes from 13 consecutive patients with FTMH after RVO who underwent pars plana vitrectomy (PPV) combined internal limiting membrane (ILM) peeling or ILM flap insertion. Clinical demographics and spectral-domain optical coherence tomography (SD-OCT) features were evaluated. Multiple linear regression was used to analyze the associated factors for the final best-corrected visual acuity (BCVA).

Results: Of the 13 eyes, 11 had a previous branch RVO (BRVO) and 2 had a central RVO (CRVO). The mean minimum linear diameter (MLD) of these secondary macular holes was 469.31 ± 197.96 μm. Eight subjects (61.5%) showed a FTMH secondary to a long-standing RVO (RVO episode longer than 6 months), and the rest 5 subjects (38.5%) developed a FTMH after a recent onset RVO within 6 months. The two groups shared similar baseline BCVA (P = 0.414), MLD (P = 0.218), and BD (P = 0.453). The mean follow-up period was 10.0 months. All cases showed anatomical closure at the last follow-up, with BCVA significantly improved from 0.90 ± 0.28 logMAR at baseline to 0.45 ± 0.34 logMAR after surgery (P<0.001). The final BCVA of the eyes after recent onset RVO was better than the ones after long-standing RVO (P = 0.012). Regression analysis showed that the final BCVA was significantly associated with the baseline BCVA, RVO duration, and the ellipsoid zone (EZ) integrity (P<0.001).

Conclusion: FTMH secondary to RVO could achieve favorable anatomical and visual acuity success with PPV. The cases secondary to a recent RVO might have a better visual prognosis. The initial BCVA and postoperative EZ recovery were associated with the final BCVA.