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Cytogenetic analysis of autistic children with down syndrome features 自闭症儿童唐氏综合征特征的细胞遗传学分析
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_112_22
Rajat Hegde, Smita Hegde, Pooja Joshi, Santoshkumar Gataraddi, Sujayendra Kulkarni, Gurushantappa Kadkol, S. Kulkarni, Kusal K. Das, P. Gai
INTRODUCTION: Autism is a heterogeneous neurodevelopmental disorder that influences a child's ability to think, learn, communicate, and interact socially and possess behavioral problems. It has also been observed to be associated with several medical conditions, including certain chromosomal disorders like Down syndrome (DS). Several studies have shown autistic individuals with DS. The main objective of the present study is to screen for chromosomal abnormalities in autistic children with DS characteristics in the North Karnataka population, India. MATERIALS AND METHODS: Chromosome analysis of peripheral blood of four DS children with autistic characteristics was performed to examine the chromosomal abnormalities, which were confirmed by fluorescent in situ hybridization. RESULTS: Childhood Autism Rating Scale score was calculated initially to assess the severity of autism. All four cases were found to have autism with DS. Out of four cases, three (75%) were found to be trisomy 21 and 1 (25%) had a trisomy 21 mosaic condition. CONCLUSION: Our study confirms the chromosomal abnormality present in autistic children with DS characteristics and these findings will contribute in several ways to the diagnosis and treatment of the genetic cause of autism with other comorbidities or vice versa.
简介:自闭症是一种异质性神经发育障碍,影响儿童的思考、学习、交流和社会互动能力,并具有行为问题。它还被观察到与几种疾病有关,包括某些染色体疾病,如唐氏综合症(DS)。一些研究表明自闭症患者患有退行性痴呆。本研究的主要目的是筛查印度北卡纳塔克邦人口中具有DS特征的自闭症儿童的染色体异常。材料与方法:对4例具有自闭症特征的DS患儿外周血进行染色体分析,观察其染色体异常情况,并采用荧光原位杂交法进行证实。结果:初步计算儿童自闭症评定量表得分来评估自闭症的严重程度。所有四个病例都被发现患有自闭症伴DS。其中3例(75%)为21三体,1例(25%)为21三体镶嵌病。结论:我们的研究证实了具有DS特征的自闭症儿童存在染色体异常,这些发现将在多个方面有助于自闭症与其他合并症的遗传原因的诊断和治疗,反之亦然。
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引用次数: 0
A cross-sectional study on quality of life and stress among medical students and interns in Central Karnataka 卡纳塔克邦中部医科学生和实习生的生活质量和压力横断面研究
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_195_22
B. Sindhu, P. Kumar, Abhinandan S. Kumbar, B. Rashmi
INTRODUCTION: Studies have shown the lower quality of life (QoL) and higher levels of stress among students of health-care courses compared to others. The present study was done to assess the QoL and perceived stress levels among medical students and interns and the correlation between them. Symptoms experienced in the case of stress and coping strategies for stress were also studied. METHODOLOGY: All students and interns in a medical college in Central Karnataka were interviewed. WHOQoL-BREF scale and Perceived Stress Scale-10 were used to assess the QoL and perceived stress levels, respectively. RESULTS: A total of 94 students participated. Psychological domain and environment domain scores (52.3 and 59.02, respectively) were lower. A significant negative correlation was observed between all the domains of QoL and stress scores. More than half of the students (60.6%) were under moderate stress. CONCLUSION: Efforts should be made to improve the QoL and reduce stress levels among medical students and interns. Various better-coping methods for stress should be taught to them.
研究表明,与其他学生相比,卫生保健课程学生的生活质量(QoL)较低,压力水平较高。本研究旨在探讨医学生和实习生的生活质量与压力感知水平及其相关关系。还研究了在压力情况下经历的症状和应对压力的策略。方法:对卡纳塔克邦中部一所医学院的所有学生和实习生进行了访谈。采用WHOQoL-BREF量表和Perceived Stress scale -10量表分别评估患者的生活质量和感知压力水平。结果:共有94名学生参与。心理领域和环境领域得分较低,分别为52.3分和59.02分。生活质量各领域与压力得分呈显著负相关。超过一半(60.6%)的学生处于中等压力状态。结论:应努力提高医学生和实习生的生活质量,降低压力水平。应该教他们各种更好的应对压力的方法。
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引用次数: 0
Knowledge, attitude, and practice of pain neuroscience education among physiotherapists: A cross-sectional survey 物理治疗师疼痛神经科学教育的知识、态度和实践:一项横断面调查
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_87_22
A. Heggannavar, Shreya Deshmukh
CONTEXT: A significant population in India suffers from chronic pain, and it is one of the most common symptoms managed by physiotherapists. Pain neuroscience education (PNE) has been found to be effective in pain management when included in a multimodal treatment. A number of misconceptions about this concept are prevailing. AIM: The aim of the study is to determine the knowledge, attitude, and practice of PNE among physiotherapists in India through a questionnaire-based survey. MATERIALS AND METHODS: A cross-sectional study was conducted among qualified practicing physiotherapists and physiotherapy academicians in India. Data were collected using an online self-reported questionnaire constructed on Google Forms Application. The link of the questionnaire was circulated among the physiotherapists via various social media platforms. STATISTICAL ANALYSIS: Percentage analysis of the responses was done using Microsoft Excel 2010. RESULTS: A total of 408 responses were subjected to statistical analysis. Only 50% of the respondents were aware of the term PNE. Most of the questions in the knowledge domain received correct responses from more than 50% of the respondents. Most of the respondents have a negative attitude toward PNE. There is poor practice of PNE among physiotherapists in India. CONCLUSION: There is lack of awareness about PNE among physiotherapists in India. Physiotherapists having good knowledge about PNE do not have a positive attitude toward it and show poor practice.
背景:印度有相当多的人患有慢性疼痛,这是物理治疗师治疗的最常见症状之一。疼痛神经科学教育(PNE)已被发现是有效的疼痛管理时,包括在一个多模式的治疗。关于这一概念的一些误解正在盛行。目的:本研究的目的是通过问卷调查确定印度物理治疗师对PNE的知识、态度和实践。材料和方法:在印度的合格执业物理治疗师和物理治疗学者中进行了一项横断面研究。数据是通过在谷歌表单应用程序上构建的在线自我报告问卷收集的。问卷的链接通过各种社交媒体平台在理疗师之间传播。统计分析:使用Microsoft Excel 2010对回复进行百分比分析。结果:对408份应答进行统计分析。只有50%的受访者知道PNE这个词。知识领域的大多数问题都得到了超过50%的受访者的正确回答。大多数受访者对PNE持否定态度。在印度的物理治疗师中,PNE的实践很差。结论:印度物理治疗师对PNE缺乏认识。物理治疗师虽然对PNE有很好的了解,但对PNE的态度不积极,表现不佳。
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引用次数: 0
Knowledge and perception on developmentally supportive care for preterm babies among staff nurses working in the neonatal intensive care unit of Tertiary Care Center in South India 南印度三级护理中心新生儿重症监护室工作人员对早产儿发育支持护理的知识和看法
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_198_22
L. Subhashini, V. Saritha, Monappa
BACKGROUND AND AIM: As neonatal nurses play a significant job in providing care to preterm babies, awareness of developmentally supportive care would result in quality care of preterm infants and improved performance in nursing care. We aimed to assess the knowledge and perception of developmentally supportive care of preterm babies among staff nurses. MATERIALS AND METHODS: A cross-sectional study was conducted among 30 registered staff nurses. A purposive sampling technique was used to select the staff nurses with 1 year of working experience at the neonatal intensive care unit (NICU) of RL Jalappa Hospital and Research Center of Kolar, Karnataka. Self-administered questionnaire was designed to collect the data employing an online literature review for the purposes specified; data were analyzed using descriptive statistics. RESULTS: We analyzed the data and found that staff nurses are having adequate knowledge (70%) with mean scores of 20.9 ± 2.8, respectively, and positive perception toward the care of preterm babies in concern to developmentally supportive care. CONCLUSION: The study concludes that the knowledge and perception of NICU nurses regarding developmentally supportive care have found to be adequate. As developmentally supportive care would result in the improved performance and skill of the nursing personnel in providing care of preterm babies, higher authorities are advised to take it into account for the proper promotion of NICU staff nurses.
背景与目的:新生儿护士在早产儿护理中起着重要的作用,认识发育支持护理可以提高早产儿的护理质量,提高护理效果。我们的目的是评估护理人员对早产儿发育支持护理的知识和认知。材料与方法:对30名注册护士进行横断面调查。采用目的抽样方法,选取卡纳塔克邦Jalappa医院和Kolar研究中心新生儿重症监护病房(NICU)具有1年工作经验的护理人员。自我管理问卷的设计是为了收集数据,采用在线文献综述为指定的目的;数据分析采用描述性统计。结果:通过对资料的分析发现,护理人员对早产儿发育支持护理的认知程度较好(70%),平均得分为20.9±2.8分,对早产儿发育支持护理的认知程度较高。结论:新生儿重症监护病房护士对发育支持护理的认识和认知是充分的。由于发育支持性护理将提高护理人员在提供早产儿护理方面的表现和技能,建议上级当局在适当提升新生儿重症监护室工作人员护士时考虑到这一点。
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引用次数: 0
A rare case of parasitic fibroid presenting as abdominopelvic mass – A surgical dilemma 一例罕见的寄生肌瘤表现为腹盆腔肿块-手术困境
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_97_22
Avinash P. Dubbewar, R. Hiremath, S. Rai, Prathyusha Gouru
Parasitic fibroids (PFs) are rare extrauterine fibroids classified as Type 8 leiomyomas as per The International Federation of Gynecology and Obstetrics (FIGO) classification, without uterine myometrial involvement or attachment. Due to its very low incidence, unusual locations, and atypical presentations, these fibroids cause lot of clinical dilemmas to treating physicians. Hereby, we are presenting an interesting case of PF which is presented to us as a case of abdominopelvic mass. Here, we learned that whenever female patients with abdominal mass and prior surgical history, PF should be considered possibilities to avoid on-table intraoperative surprises where a multidisciplinary surgical team may be required depending upon location and organ involved. We were fortunate that our PF was attached to the omentum and sigmoid colon by connective tissue and feeding vessels and could be removed without much deliberation.
寄生性肌瘤(PFs)是一种罕见的子宫外肌瘤,根据国际妇产科联合会(FIGO)分类,被归类为8型平滑肌瘤,没有子宫肌瘤累及或附着。由于其发病率极低,不寻常的位置和不典型的表现,这些肌瘤给治疗医生带来了许多临床难题。在此,我们将介绍一个有趣的PF病例它是一个腹盆腔肿块。在这里,我们了解到,只要女性患者有腹部肿块和既往手术史,就应该考虑PF的可能性,以避免术中意外,因为手术可能需要多学科的外科团队,这取决于部位和受损伤的器官。幸运的是,我们的PF通过结缔组织和喂养血管附着在网膜和乙状结肠上,无需太多考虑就可以切除。
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引用次数: 0
Importance of simulation in undergraduate medical education with specific emphasis on preclinical phase – A narrative review 模拟在本科医学教育中的重要性,特别强调临床前阶段-叙述回顾
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_200_22
YC Nalini, Shivasakthy Manivasakan, D. Pai
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引用次数: 0
Quantifying research productivity of BLDE deemed to be university: A bibliometric analysis 量化大学研究生产力:文献计量学分析
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_92_22
B. Prasanna Kumara, Shivakumar Acharya
Research articles represent the scientific community's viewpoints and serve as a guide for publishing, offering insight into the dynamics of the knowledge ecosystem in a situation that affects innovation and public policy. This bibliometric study aimed to determine the key features of research articles published at the BLDE (Deemed to be University [DU]) from 1992 to 2021, which were indexed in Scopus. A total of 847 research articles were authored by 520 writers, most of the subjects under medical science. The preferred source of BLDE (DU) authors is JCDR and Krishna Institute of Medical Sciences University Journal. Arun Inamadar was the most prolific and well-quoted author. The early stages of research publications represented contingent features of health science's global, regional, and national trajectory. Research articles enable the scientific community to participate in continuous conversations throughout the growing and fast-evolving health science crises.
研究文章代表了科学界的观点,并作为出版指南,在影响创新和公共政策的情况下,提供了对知识生态系统动态的洞察。本文献计量学研究旨在确定1992年至2021年在BLDE(被认为是大学[DU])发表的研究文章的关键特征,这些文章在Scopus中被索引。共有520位作者撰写了847篇研究论文,其中大部分属于医学学科。BLDE (DU)作者的首选来源是JCDR和Krishna医学科学研究所大学期刊。Arun Inamadar是最多产、被引用最多的作家。研究出版物的早期阶段代表了卫生科学全球、区域和国家轨迹的偶然特征。研究文章使科学界能够在不断增长和快速发展的卫生科学危机中参与持续的对话。
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引用次数: 0
A clinical study on pseudo-cyst pancreas: Clinical presentation, surgical, and different modalities of treatment and outcome 假性囊肿胰腺的临床研究:临床表现,手术,不同的治疗方式和结果
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_25_23
Veena Korishetty, Sanjeev M. Patil
BACKGROUND: Pancreatic pseudocysts are walled-off collections of necrotic tissue, old blood, and secretions that are encapsulated. Collections lack a real capsule, and the cyst wall is composed of nearby viscera such as the stomach and/or colon. Pseudocysts are the most frequent side effects of both acute and chronic pancreatic inflammation. In our prospective interventional study, 25 patients with symptomatic pancreatic pseudocysts were included. Majority of patients were belonged to the age group of 31–40 years, with males being more common. The most common cause is alcoholism, followed by idiopathy. Most of them presented with pain abdomen as the chief complaint. Ultrasonography (USG) and computed tomography (CT) of the abdomen were found to be accurate investigations. Acute pseudocysts were managed conservatively, whereas infected cysts necessitated external drainage. In the majority of cases, anastomoses of the cyst to the nearby bowel, either cystogastrostomy or cystojejunostomy, were performed with good results. METHODS: Study design - Hospital-based prospective interventional study. Sample size - 25. The study was the prospective interventional study, conducted at Basaweshwar Hospital from July 2020 to August 2022, 25 patients with symptomatic pancreatic pseudocysts included. Patients had baseline tests as well as specific tests such as serum amylase and serum lipase. All patients underwent USG and CT Abdomen to determine the morphology, and treatment was planned accordingly. RESULTS: A total of 25 patients were included in the study. Out of 25 patients, the cause of pancreatic pseudocyst was found to be alcohol consumption in 80% and other causes in 14%. The common indication for intervention was persistent pain (60%) The type of intervention was chosen based on the physical state of the patient as well as the location and type of the pseudocyst. USG-guided drainage was done in 14% and surgical drainage procedure-cystogastrostomy - 36% and cystojejunostomy 26%. CONCLUSION: The most common cystic lesion of the pancreas is the pancreatic pseudocyst. The disease was common in the age group of 31–50 years and was seen predominantly in males. The most common cause is alcoholism, followed by idiopathy. Pain in the abdomen with tenderness is a common presentation. The most useful tests were an ultrasound and a CT scan. Acute pseudocysts were managed conservatively, while infected cysts required external drainage. In the majority of cases, anastomosis of the cyst to the nearby bowel, either by cystogastrostomy or cystojejunostomy, was performed with good results.
背景:胰腺假性囊肿是封闭的坏死组织、旧血和被包裹的分泌物。囊肿缺乏真正的囊,囊肿壁由附近的脏器如胃和/或结肠组成。假性囊肿是急性和慢性胰腺炎症最常见的副作用。在我们的前瞻性介入研究中,纳入了25例有症状的胰腺假性囊肿患者。患者年龄以31 ~ 40岁为主,男性居多。最常见的原因是酗酒,其次是自发性疾病。多数以腹部疼痛为主诉。腹部超声(USG)和计算机断层扫描(CT)发现准确的调查。急性假性囊肿保守处理,而感染性囊肿则需要体外引流。在大多数病例中,将囊肿与附近的肠吻合,无论是膀胱胃吻合术还是膀胱空肠吻合术,都能取得良好的效果。方法:研究设计-基于医院的前瞻性介入研究。样本量- 25。该研究是一项前瞻性介入研究,于2020年7月至2022年8月在Basaweshwar医院进行,包括25名有症状的胰腺假性囊肿患者。患者进行基线测试以及血清淀粉酶和血清脂肪酶等特异性测试。所有患者均行超声心动图和腹部CT检查以确定形态,并制定相应的治疗方案。结果:共纳入25例患者。在25例患者中,发现80%的胰腺假性囊肿的原因是饮酒,14%是其他原因。常见的干预指征是持续性疼痛(60%)。根据患者的身体状况以及假性囊肿的位置和类型选择干预类型。usg引导引流占14%,手术引流-膀胱胃吻合术占36%,膀胱空肠吻合术占26%。结论:胰腺最常见的囊性病变是胰腺假性囊肿。本病常见于31-50岁年龄组,以男性为主。最常见的原因是酗酒,其次是自发性疾病。腹部疼痛伴压痛是常见的表现。最有用的检查是超声波和CT扫描。急性假性囊肿保守处理,而感染囊肿需要外部引流。在大多数病例中,通过囊胃吻合术或囊空肠吻合术将囊肿与附近的肠吻合,效果良好。
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引用次数: 0
Family adoption program in medical education curriculum: National medical mission recommendations, challenges, and possible solutions for better implementations 医学教育课程中的家庭收养计划:国家医学使命的建议、挑战和可能的解决方案
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_131_22
K. Annadurai, U. Sharath, S. Nachiyar
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引用次数: 0
Effect of caffeine on the amplitude of accommodation and pupil size 咖啡因对调节幅度和瞳孔大小的影响
Pub Date : 2023-01-01 DOI: 10.4103/bjhs.bjhs_155_22
Vaibhavi Naik, Mahima Chandra
PURPOSE: It is a well-known fact that caffeine is an autonomic stimulant, which is said to have a significant effect on visual performance. This study was planned to investigate the effect of caffeine on the amplitude of accommodation and pupil size in adults. MATERIALS AND METHODS: An experimental study was conducted on 54 healthy individuals in the age range of 27–39 years. All the individuals underwent comprehensive eye examinations and were given caffeine through hot coffee (4 mg/kg). Push up method was used to measure accommodative amplitude (AOA) and pupil size was measured using millimeter scale, at baseline (before consuming coffee) and at 20, 40, and 60 min after consumption of coffee. All the measurements were taken on a random eye selected prior to the study. RESULTS: After consumption of caffeine, the AOA and pupil size showed a significant increase (P < 0.001) after 40 and 60 min. AOA elevated from 9.76 standard deviation (SD) ± 1.46D at baseline to 10.79 SD ± 1.55D at 60 min. Similarly, increment in pupil size from 3.53 SD ± 0.77 mm from baseline to 4.20 SD ± 0.77 mm after 60 min was recorded. There was no correlation found between AOA and pupil size at any point of time (r < 0.2). CONCLUSION: AOA and pupil size are affected in adults after caffeine consumption and it is important to take into account the history related to caffeine consumption before ocular and orthoptic evaluation. It can influence and alter the measurements recorded.
目的:众所周知,咖啡因是一种自主神经兴奋剂,据说对视觉表现有显著影响。这项研究旨在调查咖啡因对成人调节幅度和瞳孔大小的影响。材料与方法:对54例年龄在27 ~ 39岁的健康人进行实验研究。所有人都接受了全面的眼科检查,并通过热咖啡给予咖啡因(4毫克/公斤)。采用俯卧撑法测量调节振幅(AOA),瞳孔大小采用毫米尺度测量,分别在基线(饮用咖啡前)和饮用咖啡后20、40和60分钟。所有的测量都是在研究前随机选择的一只眼睛上进行的。结果:摄入咖啡因后,40和60 min后AOA和瞳孔大小均显著增加(P < 0.001), AOA从基线时的9.76标准差(SD)±1.46D增加到60 min时的10.79 SD±1.55D, 60 min后瞳孔大小从基线时的3.53 SD±0.77 mm增加到4.20 SD±0.77 mm。AOA与瞳孔大小在任何时间点均无相关性(r < 0.2)。结论:成人摄入咖啡因后AOA和瞳孔大小受到影响,在眼科和正视镜检查前考虑与咖啡因摄入有关的病史是很重要的。它可以影响和改变所记录的测量值。
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引用次数: 0
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BLDE University Journal of Health Sciences
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